20-06-2013 дата публикации
Номер: US20130158112A1
Принадлежит:
A pharmaceutical composition for inhibiting amyloid beta peptide in a subject includes a compound having the formula (I): 4. The pharmaceutical composition of claim 2 , where Rand Rare independently selected from H claim 2 , Cl claim 2 , CH claim 2 , OH claim 2 , NO claim 2 , F claim 2 , Br claim 2 , CF claim 2 , or an alkoxy group.5. The pharmaceutical composition of claim 2 , where Z is selected from Cl claim 2 , alkoxy claim 2 , OH claim 2 , CN claim 2 , C(NH)NOH claim 2 , NO claim 2 , NH claim 2 , COEt claim 2 , COOH claim 2 , CONH claim 2 , F claim 2 , CH claim 2 , CHO claim 2 , CF claim 2 , BR claim 2 , I claim 2 , CONHCH claim 2 , NHCOCHand OCHCHOCHCHOH.12. The method of where Rand Rare independently selected from H claim 10 , Cl claim 10 , CH claim 10 , OH claim 10 , NO claim 10 , F claim 10 , Br claim 10 , CFand an alkoxy group.13. The method of claim 10 , where Z is selected from Cl claim 10 , alkoxy claim 10 , OH claim 10 , CN claim 10 , C(NH)NOH claim 10 , NO claim 10 , NH claim 10 , COEt claim 10 , COOH claim 10 , CONH claim 10 , F claim 10 , CH claim 10 , CHO claim 10 , CF claim 10 , BR claim 10 , I claim 10 , CONHCH claim 10 , NHCOCHand OCHCHOCHCHOH.19. The method of where Rand Rare independently selected from H claim 17 , Cl claim 17 , CH claim 17 , OH claim 17 , NO claim 17 , F claim 17 , Br claim 17 , CFand an alkoxy group.20. The method of claim 17 , where Z is selected from Cl claim 17 , alkoxy claim 17 , OH claim 17 , CN claim 17 , C(NH)NOH claim 17 , NO claim 17 , NH claim 17 , COEt claim 17 , COOH claim 17 , CONH claim 17 , F claim 17 , CH claim 17 , CHO claim 17 , CF claim 17 , BR claim 17 , I claim 17 , CONHCH claim 17 , NHCOCHand OCHCHOCHCHOH.23. The method of claim 16 , the pharmaceutical composition promoting neuronal survival in the subject. This application claims priority from U.S. Provisional Application No. 61/498,847, filed Jun. 20, 2011, the subject matter of which is incorporated herein by reference in its entirety.This ...
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