04-06-2015 дата публикации
Номер: US20150150901A1
Принадлежит:
Methods of treating diseases such as diabetes are disclosed. Methods of modulating elevated fructosamine levels, elevated HbAlc levels, impaired glucose tolerance, and impaired fasting glucose are also disclosed. In some embodiments, methods include co-administration of a bile acid sequestrant and two or more additional compounds selected from the group consisting of a biguanide, a sulfonylurea and insulin, or pharmaceutically acceptable salts thereof. Drug products including a bile acid sequestrant and two or more additional compounds selected from the group consisting of a biguanide, a sulfonylurea and insulin, or pharmaceutically acceptable salts thereof, in combination are also disclosed. 1. A method for treating diabetes in a human in need of such treatment , the method comprising administering to said human therapeutically effective amounts of a bile acid sequestrant and two or more additional compounds selected from the group consisting of a biguanide , a sulfonylurea , insulin , and pharmaceutically acceptable salts thereof.2. The method of claim 1 , wherein the bile acid sequestrant and the two or more compounds are administered substantially simultaneously.3. The method of claim 1 , wherein the bile acid sequestrant and the two or more compounds are administered separately.4. The method of claim 2 , wherein the bile acid sequestrant and the two or more compounds are administered within one hour of each other.5. The method of claim 3 , wherein the bile acid sequestrant and the two or more compounds are administered within twelve hours of each other.6. The method of claim 1 , wherein the bile acid sequestrant is selected from the group consisting of colesevelam claim 1 , cholestyramine claim 1 , and colestipol; the biguanide comprises metformin; and the sulfonylurea is selected from the group consisting of glipizide claim 1 , glyburide glimepiride claim 1 , gliclazide claim 1 , glibenclamide claim 1 , gliquidone claim 1 , acetohexamide claim 1 , ...
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