System, method, and computer program for allowing users access to information from a plurality of external systems utilizing a user interface

A system, method, and computer program product are provided for allowing users to access information from a plurality of external systems utilizing a user interface. In use, a plurality of external systems with which to communicate are identified. Additionally, a connection type associated with each of the plurality of external systems is identified. Further, information associated with each of the plurality of external systems to access is identified. In addition, a plurality of logical modules are configured based on the identified information. Furthermore, user groups are identified for each of the plurality of logical modules. Moreover, access levels associated with each of the plurality of logical modules are defined for each of the identified user groups.

Instruments and methods for adjusting separation distance of vertebral bodies with a minimally invasive spinal stabilization procedure

A spinal stabilization system may be formed in a patient. In some embodiments, a minimally invasive procedure may be used to form a spinal stabilization system in a patient. Bone fastener assemblies may be coupled to vertebrae. Each bone fastener assembly may include a bone fastener and a collar. Extenders may be coupled to the collar to allow for formation of the spinal stabilization system through a small skin incision. The extenders may allow for alignment of the collars to facilitate insertion of an elongated member in the collars. An elongated member may be positioned in the collars and a closure member may be used to secure the elongated member to the collars. An adjuster may be used in conjunction with the extenders to change a separation distance between the bone fastener assemblies.

Spinal stabilization systems and methods

A spinal stabilization system may be formed in a patient. In some embodiments, a minimally invasive procedure may be used to form a spinal stabilization system in a patient Bone fastener assemblies may be coupled to vertebrae Each bone fastener assembly may include a bone fastener and a collar. The collar may be rotated and/or angulated relative to the bone fastener. Detachable members may be coupled to the collar to allow for formation of the spinal stabilization system through a small skin incision. The detachable members may allow for alignment of the collars to facilitate insertion of an elongated member in the collars. An elongated member may be positioned in the collars and a closure member may be used to secure the elongated member to the collars.

INSTRUMENTS AND METHODS FOR ADJUSTING SEPARATION DISTANCE OF VERTEBRAL BODIES WITH A MINIMALLY INVASIVE SPINAL STABILIZATION PROCEDURE

A spinal stabilization system may be formed in a patient. In some embodiments, a minimally invasive procedure may be used to form a spinal stabilization system in a patient. Bone fastener assemblies may be coupled to vertebrae. Each bone fastener assembly may include a bone fastener and a collar. Extenders may be coupled to the collar to allow for formation of the spinal stabilization system through a small skin incision. The extenders may allow for alignment of the collars to facilitate insertion of an elongated member in the collars. An elongated member may be positioned in the collars and a closure member may be used to secure the elongated member to the collars. An adjuster may be used in conjunction with the extenders to change a separation distance between the bone fastener assemblies. 1. A system for adjusting a distance between vertebral bodies of a human spine , comprising:a first extender coupled to a first bone fastener assembly that is secured to a first vertebral body, wherein a closure member secures an elongated member to the first bone fastener assembly to inhibit movement of the elongated member relative to the first bone fastener assembly;a second extender coupled to a second bone fastener assembly that is secured to a second vertebral body;an adjuster, wherein a portion of the adjuster is configured to couple to the first extender;a driver configured to couple to the adjuster and to the second extender; andwherein the adjuster is configured to allow the driver to move the second extender relative to the elongated member to adjust the separation distance between the first vertebral body and the second vertebral body.2. The system of claim 1 , wherein an extender engager couples the adjuster to the first extender claim 1 , and wherein the driver is configured to rotate relative to the extender engager.3. The system of claim 2 , wherein the extender engager comprises a shaft configured to be inserted into the first extender.4. The system of claim 2 , ...

System, method, and computer program for automatically accessing data in a database based on query information

A system, method, and computer program product are provided for automatically accessing data in a database based on query information. In use, query information is received from a user interface, the query information including at least one selection of a preconfigured set of queries that are grouped logically based on a team or an application and the query information further including input parameters defined by a user utilizing the user interface. Additionally, data to access in at least one database is identified based on the query information. Further, a connection with the at least one database is automatically established, the connection with the at least one database being established utilizing a predefined database connection for one or more environments with which the user interface is associated. Moreover, the data in the at least one database is automatically accessed based on the query information.

SPINAL STABILIZATION SYSTEMS AND METHODS

A spinal stabilization system may be formed in a patient. In some embodiments, a minimally invasive procedure may be used to form a spinal stabilization system in a patient Bone fastener assemblies may be coupled to vertebrae Each bone fastener assembly may include a bone fastener and a collar. The collar may be rotated and/or angulated relative to the bone fastener. Detachable members may be coupled to the collar to allow for formation of the spinal stabilization system through a small skin incision. The detachable members may allow for alignment of the collars to facilitate insertion of an elongated member in the collars. An elongated member may be positioned in the collars and a closure member may be used to secure the elongated member to the collars. 120-. (canceled)21. A system for performing spine surgery , said system comprising:a first bone screw configured to be screwed into a first vertebra;a first collar coupled to the first bone screw, said first collar comprising a first slot;a second bone screw configured to be screwed into a second vertebra;a second collar coupled to the second bone screw, said second collar comprising a second slot;a rod, said rod having a width sized to fit within the first slot and the second slot;a first sleeve comprising a first passage, said first passage extending longitudinally from a first end of the first sleeve to a second end of the first sleeve;a first closure member configured to be secured to the first collar for securing the rod within the first slot;a second sleeve comprising a second passage, said second passage extending longitudinally from a first end of the second sleeve to a second end of the second sleeve; anda second closure member configured to be secured to the second collar for securing the rod within the second slot;wherein the first sleeve and the first collar comprise a first coupling system for coupling the first collar to the first sleeve;wherein the second sleeve and the second collar comprise a second ...

SPINAL STABILIZATION SYSTEMS AND METHODS

A spinal stabilization system may be formed in a patient. In some embodiments, a minimally invasive procedure may be used to form a spinal stabilization system in a patient Bone fastener assemblies may be coupled to vertebrae Each bone fastener assembly may include a bone fastener and a collar. The collar may be rotated and/or angulated relative to the bone fastener. Detachable members may be coupled to the collar to allow for formation of the spinal stabilization system through a small skin incision. The detachable members may allow for alignment of the collars to facilitate insertion of an elongated member in the collars. An elongated member may be positioned in the collars and a closure member may be used to secure the elongated member to the collars. 1. A system for performing spine surgery , said system comprising:a first bone screw configured to be screwed into a first vertebra;a first collar coupled to the first bone screw, said first collar comprising a first slot;a second bone screw configured to be screwed into a second vertebra;a second collar coupled to the second bone screw, said second collar comprising a second slot;a rod, said rod having a width sized to fit within the first slot and the second slot;a first sleeve comprising a first passage, said first passage extending longitudinally from a first end of the first sleeve to a second end of the first sleeve;a first closure member configured to be secured to the first collar for securing the rod within the first slot;a second sleeve comprising a second passage, said second passage extending longitudinally from a first end of the second sleeve to a second end of the second sleeve;a second closure member configured to be secured to the second collar for securing the rod within the second slot;wherein the first sleeve and the first collar comprise a first coupling system for coupling the first collar to the first sleeve, said first coupling system configured to provide a detachable mechanical coupling ...

Spinal stabilization systems and methods

A spinal stabilization system may be formed in a patient. In some embodiments, a minimally invasive procedure may be used to form a spinal stabilization system in a patient Bone fastener assemblies may be coupled to vertebrae Each bone fastener assembly may include a bone fastener and a collar. The collar may be rotated and/or angulated relative to the bone fastener. Detachable members may be coupled to the collar to allow for formation of the spinal stabilization system through a small skin incision. The detachable members may allow for alignment of the collars to facilitate insertion of an elongated member in the collars. An elongated member may be positioned in the collars and a closure member may be used to secure the elongated member to the collars.

Instruments and methods for adjusting separation distance of vertebral bodies with a minimally invasive spinal stabilization procedure

A spinal stabilization system may be formed in a patient. In some embodiments, a minimally invasive procedure may be used to form a spinal stabilization system in a patient. Bone fastener assemblies may be coupled to vertebrae. Each bone fastener assembly may include a bone fastener and a collar. Extenders may be coupled to the collar to allow for formation of the spinal stabilization system through a small skin incision. The extenders may allow for alignment of the collars to facilitate insertion of an elongated member in the collars. An elongated member may be positioned in the collars and a closure member may be used to secure the elongated member to the collars. An adjuster may be used in conjunction with the extenders to change a separation distance between the bone fastener assemblies.

COLLAPSIBLE, REUSABLE STORAGE CONTAINER

A collapsible, reusable bulk material container assembly, kit and method for assembling and using same are disclosed. Upper ring and base members are locked together by peripheral post members, forming an upright rigid framework that operatively supports a woven fabric bulk material receiving bag. A cover connected to the upper ring seals the container. Intermediate support bands may be attached to and along the post members to resist outwardly directed forces applied to the bag by contained bulk material. The container is reconfigurable to a collapsed storage or shipping module that retainably contains the post members, support bands and woven fabric bag. The post members may be segmentable or collapsible for containment within the collapsed module. Component parts of the container assembly are detachable, reusable and recyclable. One configuration of the container is sized to replace a conventional 55 gallon drum. 1. A collapsible container assembly suitable for holding a charge of bulk material for storage and transport , comprising: (i) a base having a footprint perimeter defining a first closed geometric shape, and having a bottom with strength sufficient to support said charge of bulk material;', '(ii) An upper member defining a perimeter similar to said first geometric shape and having an open architecture defining an opening therethrough suitable for receiving said charge of bulk material; and', '(iii) A plurality of post members detachably connecting and peripherally extending between said base member and said upper member;, '(a) a rigid collapsible framework defining an internal geometrically shaped volume, comprising(b) a continuously woven fabric sleeve sized and configured to fit within said internal geometrically shaped volume of said framework, said sleeve forming a bottom and having an open upper end for receiving said charge of bulk material into the sleeve and having strength and bulge resistance parameters suitable for containing said charge of ...

SPINAL STABILIZATION SYSTEMS AND METHODS

A spinal stabilization system may be formed in a patient. In some embodiments, a minimally invasive procedure may be used to form a spinal stabilization system in a patient Bone fastener assemblies may be coupled to vertebrae Each bone fastener assembly may include a bone fastener and a collar. The collar may be rotated and/or angulated relative to the bone fastener. Detachable members may be coupled to the collar to allow for formation of the spinal stabilization system through a small skin incision. The detachable members may allow for alignment of the collars to facilitate insertion of an elongated member in the collars. An elongated member may be positioned in the collars and a closure member may be used to secure the elongated member to the collars. 1. A delivery device for delivering a spinal rod to a bone anchor , comprising:an inner member having proximal and distal ends and a lumen extending therebetween, the distal end being configured to releasably engage a collar of a bone anchor, wherein the inner member has a first slot formed therein, the first slot having an opening at a distal end of the inner member and extending a first slot length toward the proximal end of the inner member;an outer member disposed over at least a portion of the inner member, the outer member having proximal and distal ends and a lumen extending therebetween, the distal end of the outer member being configured to maintain engagement of the distal end of the inner member with the collar, wherein the outer member has a second slot formed therein aligned with the first slot, the second slot having an opening at the distal end of the outer member and extending a second slot length toward the proximal end of the outer member, the first slot length and the second slot length sized to span at least from a skin incision in a patient to the distal ends of the inner member and the outer member, respectively, such that the first slot and the second slot may be accessible from outside of the ...

Apparatus, kit and method of assembly of a collapsible bulk material container

A collapsible bulk material container apparatus, kit and method of assembly employ a forming member having a plurality of interconnected sidewalls, a locking mechanism that fixedly orients the sidewalls continuously about an internal bulk material receiving cavity, and a tubular open-ended woven fabric sleeve that supportively overlies the sidewalls. A connector system rapidly engageable during container assembly, fixedly secures the support sleeve of an unloaded container against subsequent upward movement along the sidewalls. Strategically located friction reducing surfaces of the forming member facilitates sliding assembly of the sleeve over the forming member sidewalls.

COLLAPSIBLE BULK MATERIAL SLEEVE AND CONTAINER

A collapsible bulk material container and sleeve configuration thereof are disclosed. The container includes a forming member assembly that provides container rigidity and stability and forms an internal geometric volumetric cavity for containing a bulk material load. A continuously woven sleeve having contiguous woven zones of selectable varied fabric weight and strength engage the forming member and provide the primary containment strength of the container. The sleeve engages the forming member either externally or internally. The sleeve includes a fabric weight zone of greatest strength adjacent the lower portion of the container. 1. A collapsible bulk material container for containing a load of bulk material , comprising: (i) vertical support members extending between lower and upper ends; and', '(ii) a locking assembly cooperatively engaging said vertical support members to operatively configure and fix predetermined peripheral relative positions of said support members and to form therewith an internal geometric volumetric cavity to receive said load of bulk material; and, '(a) a collapsible forming member arranged and configured to provide a desired rigidity and shape to the container comprising(b) a support sleeve of continuously woven fabric material operatively engaging said forming member and configured to surround said internal geometric volumetric cavity to provide primary containment support for said bulk material container to counteract outward radial forces applied to said forming member by a load of bulk material contained within said cavity; said sleeve having a plurality of transverse contiguous zones of said continuously woven fabric extending from an upper edge to a lower edge of said sleeve, said zones having selective fabric weights and strengths; wherein at least one fabric zone of greater strength extends along a sleeve location that engages said vertical support members adjacent said lower ends thereof and extends upwardly therefrom to a ...

COLLAPSIBLE REUSABLE PALLET

A pallet for supportively carrying and transporting goods as a unit load in a stable efficient manner is disclosed. The pallet can be configured as a rigid or easily disassemblable compact collapsed structure. Interlocking frame members form an upper planar surface with one or more gap or void areas. A sheet of flexible material operatively secured to the frame is tautly stretched to overlie the void areas and forms a structural part of the upper planar surface to counteract downward load forces applied to the fabric over the pallet surface void areas. The sheet material preferably comprises woven polypropylene material. 1. A pallet configured to rest upon a lower support surface and to support a load having a maximum load weight , comprising:(a) a frame having a plurality of interconnected first and second frame members oriented generally perpendicularly to one another with at least some of said first and said second frame members having coplanar upper surfaces cooperatively defining a planar upper deck surface with at least one void or gap region in said planar deck surface;(b) a continuous sheet of material overlying said deck surface, secured to and tautly stretched between at least two of said frame members and overlying said at least one void or gap region in said plane, to provide upward support forces to counteract downward forces applied to said sheet material by a load placed on and carried by said upper deck surface and engaging said sheet material above said at least one void or gap region; wherein the strength of said sheet upward support forces is at least equal to or greater than downward load forces that could be produced by said load and having said maximum load weight; and(c) spaced leg members operatively connected to said frame so as to support said upper deck surface in spaced relationship above said lower support surface, to enable pallet lifting arms to be inserted between said leg members and under said upper deck to lift said pallet above ...

Bulk material container, sleeve and method of assembly

A collapsible bulk material container with a unique outer support sleeve and method of manufacture thereof are disclosed. The initial inner circumference of an oversized continuous woven tubular support sleeve is adjustably sized to mattingly match the outer peripheral circumference of a bulk material container forming member which it is designed to support. One or more adjustment tails are formed from the continuous sleeve material to accurately reduce the initial inner sleeve circumference to an adjusted inner circumference. The sizing operation can be performed during initial manufacture of the sleeve or prior to assembly of the sleeve to the forming member.

COLLAPSIBLE BULK MATERIAL CONTAINER

A collapsible, reusable bulk material container assembly, kit and method for assembling and using same are disclosed. Upper ring and base members are locked together by peripheral post members, forming an upright rigid framework that operatively supports a woven fabric bulk material receiving sleeve. A cover connected to the upper ring seals the container. Intermediate support bands may be attached to and along the post members to resist outwardly directed forces applied to the post members through the sleeve by contained bulk material. The container is reconfigurable to a collapsed storage or shipping module that retainably contains the post members, support bands and woven fabric sleeve. The post members may be segmentable or collapsible for containment within the collapsed module. Component parts of the container assembly are detachable, reusable and recyclable. One configuration of the container is sized to replace a conventional 55-gallon drum 1. A collapsible container assembly suitable for holding a charge of bulk material for storage and transport , comprising: (i) a rigid base having a footprint perimeter defining a first closed geometric shape, and having a bottom portion with a broad upper surface and strength sufficient to support said charge of bulk material;', '(ii) a rigid upper member having a perimeter defining a closed geometric shape similar to that of said first closed geometric shape, and defining an opening therethrough suitable for receiving said charge of bulk material; and', '(iii) a plurality of rigid post members detachably fixedly connecting and peripherally extending between said rigid base and said rigid upper member to form a rigid framework therewith;, '(a) a rigid collapsible framework defining an internal geometrically shaped volume, comprising(b) a woven fabric sleeve sized and configured to operatively fit within said internal geometrically shaped volume of said framework, said sleeve having a closed bottom or having a lower open ...

INSTRUMENTS AND METHODS FOR ADJUSTING SEPARATION DISTANCE OF VERTEBRAL BODIES WITH A MINIMALLY INVASIVE SPINAL STABILIZATION PROCEDURE

A spinal stabilization system may be formed in a patient. In some embodiments, a minimally invasive procedure may be used to form a spinal stabilization system in a patient. Bone fastener assemblies may be coupled to vertebrae. Each bone fastener assembly may include a bone fastener and a collar. Extenders may be coupled to the collar to allow for formation of the spinal stabilization system through a small skin incision. The extenders may allow for alignment of the collars to facilitate insertion of an elongated member in the collars. An elongated member may be positioned in the collars and a closure member may be used to secure the elongated member to the collars. An adjuster may be used in conjunction with the extenders to change a separation distance between the bone fastener assemblies. 1. A system for adjusting a distance between vertebral bodies of a human spine , comprising:a first extender configured to detachably couple to a first bone fastener assembly that is securable to a first vertebral body;a second extender configured to detachably couple to a second bone fastener assembly that is securable to a second vertebral body, wherein one of the first and second bone fastener assemblies secures to a rod so as to inhibit movement relative to the rod, and the other of the first and second bone fastener assemblies is movably coupled to the rod to allow movement along the rod relative to the secured bone fastener assembly; and a handle having a longitudinal axis;', 'a pivot member coupled to a first end of the handle, the pivot member including a driver engager; and', 'a shaft coupled to the first end of the handle, the shaft extending substantially perpendicular to the handle, the shaft configured to engage one of the first and second extenders., 'an adjuster having2. The system of claim 1 , wherein the pivot member includes a pivot element that rotates freely within a holder claim 1 , wherein the holder is attached to the handle.3. The system of claim 1 , ...

SPINAL STABILIZATION SYSTEMS AND METHODS

A spinal stabilization system may be formed in a patient. In some embodiments, a minimally invasive procedure may be used to form a spinal stabilization system in a patient Bone fastener assemblies may be coupled to vertebrae Each bone fastener assembly may include a bone fastener and a collar. The collar may be rotated and/or angulated relative to the bone fastener. Detachable members may be coupled to the collar to allow for formation of the spinal stabilization system through a small skin incision. The detachable members may allow for alignment of the collars to facilitate insertion of an elongated member in the collars. An elongated member may be positioned in the collars and a closure member may be used to secure the elongated member to the collars. 1. A pedicle screw assembly comprising:a threaded shaft;a housing configured to receive the threaded shaft and a fixation element; andan extension coupled with the housing, the extension having a length sufficient such that the extension extends above a patient's skin when the screw is secured to the patient's vertebra, wherein the extension and housing are adapted to be separated at a break-off region.2. The pedicle screw assembly of claim 1 , wherein the shaft is cannulated.3. The pedicle screw assembly of claim 1 , wherein the pedicle screw extends along a longitudinal axis claim 1 , and the housing includes a portion that is substantially “U”-shaped in a longitudinal cross-section relative to the longitudinal axis.4. The pedicle screw assembly of claim 1 , wherein the extension has one or more slots configured to allow passage of a fixation element to a target site.5. The pedicle screw assembly of claim 1 , wherein the extension extends along a longitudinal axis and has a proximal portion that is substantially “C”-shaped in a transverse cross section relative to the longitudinal axis.6. The pedicle screw assembly of claim 5 , wherein the substantially “C”-shaped proximal portion of the extension defines a guide ...

COLLAPSIBLE REUSABLE PALLET

A pallet for supportively carrying and transporting goods as a unit load in a stable efficient manner is disclosed. The pallet can be configured as a rigid or easily disassemblable compact collapsed structure. Interlocking frame members form an upper planar surface with one or more gap or void areas. A sheet of flexible material operatively secured to the frame is tautly stretched to overlie the void areas and forms a structural part of the upper planar surface to counteract downward load forces applied to the fabric over the pallet surface void areas. The sheet material preferably comprises woven polypropylene material. 1. A pallet configured to rest upon a lower support surface and to support a load having a maximum load weight , comprising:(a) a frame having a plurality of interconnected first and second frame members oriented generally perpendicularly to one another with at least some of said first and said second frame members having coplanar upper surfaces cooperatively defining a planar upper deck surface with at least one void or gap region in said planar deck surface;(b) a continuous sheet of material overlying said deck surface, secured to and tautly stretched between at least two of said frame members and overlying said at least one void or gap region in said plane, to provide upward support forces to counteract downward forces applied to said sheet material by a load placed on and carried by said upper deck surface and engaging said sheet material above said at least one void or gap region; wherein the strength of said sheet upward support forces is at least equal to or greater than downward load forces that could be produced by said load and having said maximum load weight; and(c) spaced leg members operatively connected to said frame so as to support said upper deck surface in spaced relationship above said lower support surface, to enable pallet lifting arms to be inserted between said leg members and under said upper deck to lift said pallet above ...

Modified internucleoside linkages

Oligonucleotide analogs are disclosed wherein one or more phosphodiester linkages between adjacent nucleotides are replaced by a backbone linkage resistant to nucleases. The modified oligonucleotides are capable of strong hybridization to target RNA or DNA. These oligonucleotide analogs are useful in therapies which modulate gene expression using 'antisense' or other specifically binding oligomers.

Distraction pins for fluid aspiration

A distraction pin for aspiration of a bone fluid and marrow. The pin includes an elongate metallic shaft of generally uniform diameter having a proximate end. The proximate end of the shaft includes an adaptor (attachment means) and a longitudinal bore extending from the distal end to the proximate end. The distal end of the shaft includes threading adapted for screwing the shaft into bone. The distal end also includes at least two fenestrations transverse to the longitudinal bore.

System and method for stabilizing the human spine with a bone plate

A spinal plate system and method for fixation of the human spine is provided. In an embodiment, the spinal fixation system includes a plate, a coupling member and a locking system for substantially locking the coupling member in a desired position. The plate preferably has a borehole that allows the coupling member to couple the plate with a bone. Preferably, at least a portion of the coupling member may swivel in the hole so that a bottom end of the member extends at a plurality of angles substantially oblique to the plate. The locking system preferably locks the coupling member in desired positions relative to the plate. An assembly tool is preferably used to inhibit rotation of the coupling member during the installation of the spinal fixation system.

Surgical cable system and method

A surgical cable system and method for securing surgical cable around a portion of a human element (e.g., bone) is described. The surgical cable system may include a connector and a tensioner. The connector may be adapted to hold a pin, positionable within the connector, such that the pin may secure the cable within the connector. The pin may be repositioned, after securing the cable, to allow the cable to move freely through the connector. The cable may be oriented within the connector such that the ends of the cable are perpendicular or parallel with respect to each other. The tensioner is preferably adapted to vary the tension of the cable. The cable may be passed through the connector, around a portion of a human bone, and back through the connector. The cable may be tensioned by use of the tensioner and secured into position within the connector. The connector may include a locking portion for engaging a protrusion formed on the pin. The engagement of the protrusion with the locking portion preferably inhibits rotation of the pin.

Method for producing finely divided polyvinyl chloride

Surgical retractor and retractor assembly

Retractor for insertion in an incision of a patient includes a frame defining a central opening and a reference plane, and at least one blade disposed within the central opening. The blade operatively coupled to the frame by a support structure for movement in a first direction generally laterally with the reference plane between an unretracted position and a retracted position, a second direction at an angle extending through and relative to the reference plane for adjustment of the blade depth, and a third direction rotationally relative to the reference plane. Additionally, the frame includes a track in mating relationship with the support structure for sliding movement therebetween in a defined relationship relative to the reference plane. Retractor assembly includes the retractor as previously described, in combination with an adjustment tool or an insertion tool.

Occipito-cervical stabilization system and method

A system ( 10 ) and associated method are provided for mechanically fixating a region of a skull to a portion of a spine. A plate ( 20 ) is provided to contact a region of the skull and be secured thereto. A spinal rod ( 22 ) is configured to extend from a location adjacent the plate ( 20 ) to a location adjacent at least one vertebra ( 30 ). A variable connection ( 24 ) is provided to secure the rod ( 22 ) to the plate ( 20 ). The variable connection ( 24 ) has a first mode wherein the relative position of the rod ( 22 ) to the plate ( 20 ) can be adjusted and a second mode wherein the relative position of the rod ( 22 ) to the plate ( 20 ) is locked at a particular value selected to maintain a desired curvature of the spine.

Pyrimidine derivatives for labeled binding partners

A compound having the structure: ##STR1## wherein R 1 is an oligonucleotide; a is 1 and b is 0; A is C or CH; X is S, O, NH or NCH 2 R 6 ; Z is taken together with A to form an aryl ring structure comprising 6 ring atoms wherein the aryl ring carbon atoms are unsubstituted with other than H or at least 1 nonbridging ring carbon atom is substituted with R 6 or ═O; R 6 is independently H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, NO 2 , N(R 3 ) 2 , C.tbd.N or halo, or an R 6 is taken together with an adjacent Z group R 6 to complete a phenyl ring; and R 3 is a protecting group or H; and tautomers, solvates and salts thereof.

Oligonucleotides containing 5-propynyl pyrimidines

Oligonucleotides with enhanced hybridization binding possessing 5-propynyluracil and/or 5-propynylcytosine in place of uracil and cytosine, respectively. These oligonucleotides are useful in traditional hybridization assays for detection of a specific DNA sequence.

Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines

Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines

Novel oligomers are disclosed which have enhanced ability with respect to forming duplexes or triplexes compared with oligomers containing only conventional bases. The oligomers contain the bases 5-(1-propynyl)uracil, 5-(1-propynyl)cytosine or related analogs. The oligomers of the invention are capable of (i) forming triplexes with various target sequences such as virus or oncogene sequences by coupling into the major groove of a target DNA duplex at physiological pH or (ii) forming duplexes by binding to single-stranded DNA or to RNA encoded by target genes. The oligomers of the invention can be incorporated into pharmaceutically acceptable carriers and can be constructed to have any desired sequence, provided the sequence normally includes one or more bases that is replaced with the analogs of the invention. Compositions of the invention can be used as pharmaceutical agents to treat various diseases such as those caused by viruses and can be used for diagnostic purposes in order to detect viruses or disease conditions.

Adjustable transverse connector

A transverse connector may be attached to rods of an orthopedic stabilization system. The rods of the stabilization system may be non-parallel and skewed in orientation relative to each other. The transverse connector may include two members that are joined together by a fastener. The transverse connector may be adjustable in three separate ways to allow the transverse connector to attach to the rods. The length of the transverse connector may be adjustable. The rod openings of the transverse connector may be partially rotatable about a longitudinal axis of the transverse connector. Also, a first member may be angled towards a second member so that the transverse connector can be attached to rods that are diverging. The transverse connector may include cam locks that securely attach the transverse connector to the rods. Rotating a cam locks may extend a rod engager into a rod opening. The rod engager may be a portion of the cam lock. The extension of the rod engager into a rod opening may push a rod against a body of the transverse connector to form a frictional engagement between the transverse connector, the rod, and the rod engager.

Spinal rod translation instrument

An instrument may be used to move a rod attached to vertebrae to an opening of a fixation device. Positioning the rod in the opening may properly align the vertebrae with respect to the vertebra attached to the fixation element. A fixation holder may be coupled to the fixation element. The holder may include a protrusion. The protrusion may engage a guide of the instrument during use. The protrusion and the guide may ensure that the rod is properly positioned within the opening in the connector. The instrument and holder may automatically align the rod to the opening without requiring manual manipulation of the rod or the fixation element. The fixation element may include a connector. The connector may be positioned within the fixation element so that removal of the connector from the fixation element is inhibited.

Instruments and methods for adjusting separation distance of vertebral bodies with a minimally invasive spinal stabilization procedure

A spinal stabilization system may be formed in a patient. In some embodiments, a minimally invasive procedure may be used to form a spinal stabilization system in a patient. Bone fastener assemblies may be coupled to vertebrae. Each bone fastener assembly may include a bone fastener and a collar. Extenders may be coupled to the collar to allow for formation of the spinal stabilization system through a small skin incision. The extenders may allow for alignment of the collars to facilitate insertion of an elongated member in the collars. An elongated member may be positioned in the collars and a closure member may be used to secure the elongated member to the collars. An adjuster may be used in conjunction with the extenders to change a separation distance between the bone fastener assemblies.

Modified internucleoside linkages having one nitrogen and two carbon atoms

Oligonucleotide analogs are disclosed wherein one or more phosphodiester linkages between adjacent nucleotides are replaced by a backbone linkage resistant to nucleases. The modified oligonucleotides are capable of strong hybridization to target RNA or DNA. The oligomers of the invention may be used as diagnostic reagents to detect the presence or absence of the target DNA or RNA sequences to which they bind.

Nucleotide analogs

A cyclic nucleotide phosphonate ester characterized by the presence of an n-butyl salicylate ester group linked to the phosphorus atom of cHPMPC is disclosed. The analog comprises an ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog.

Collapsible reusable pallet

A pallet for supportively carrying and transporting goods as a unit load in a stable efficient manner is disclosed. The pallet can be configured as a rigid or easily disassemblable compact collapsed structure. Interlocking frame members form an upper planar surface with one or more gap or void areas. A sheet of flexible material operatively secured to the frame is tautly stretched to overlie the void areas and forms a structural part of the upper planar surface to counteract downward load forces applied to the fabric over the pallet surface void areas. The sheet material preferably comprises woven polypropylene material.

Heterocyclic endo alicyclic end capped resins

Pyrimidine derivatives for labeled binding partners

Compounds having particular interest as labels and various novel uses in diagnostics and therapeutics are provided which have structure (1) wherein R 1 is a binding partner, a linker or H; a and b are 0 or 1, provided that the total of a and b is 0 or 1; A is N or C; X is S, O, —C(O)—, NH or NCH 2 R 6 ; Y is —C(O)—; Z is taken together with A to form an aryl or heteroaryl ring structure comprising 5 or 6 ring atoms wherein the heteroaryl ring comprises a single O ring heteroatom, a single N ring heteroatom, a single S ring heteroatom, a single O and a single N ring heteroatom separated by a carbon atom, a single S and a single N ring heteroatom separated by a carbon atom, 2 N ring heteroatoms separated by a carbon atom, or 3 N ring heteroatoms at least two of which are separated by a carbon atom, and wherein the aryl or heteroaryl ring carbon atoms are unsubstituted with other than H or at least 1 nonbridging ring carbon atom is substituted with R 6 or ═O; R 6 is independently H, C 1 -C 6 alkyl, C 2 -C 6 alkeny, C 2 -C 6 alkynyl, NO 2 , N(R 3 ) 2 , C≡N or halo, or an R 6 is taken together with an adjacent R 6 to complete a ring containing 5 or 6 ring atoms;, R 3 is a protecting group or H; and tautomers, solvates and salts thereof; and provided that where a is 0, b is 1, and R 1 is  in which D 2 is independently hydroxyl, blocked hydroxyl, mono, di or triphosphate, or an oligodeoxyribonucleotide otherwise containing only the bases A, G, T and C; and D 3 is H or OH; then Z is not unsubstituted phenyl. Also provided are novel intermediates and methods for the preparation and use of the structure (1) compounds.

Interbody fusion device and associated methods

A method and apparatus is provided for use in spinal fusion procedures. An interbody fusion device has a first piece that is a load bearing device designed to bear the axial loading from the end plates of adjacent vertebrae. A second piece of the interbody fusion device is a retention device whose function is to prevent migration of the load bearing device. One or more fasteners secure the retention device to the vertebrae above and below the load bearing device. The fasteners cause the end plates of the vertebrae to compress the end plates to the load bearing device to facilitate proper fusion.

Artificial disc with unique articulating geometry and associated methods

An apparatus and method is provided relating to artificial discs. An artificial disc (30) is provided that facilitates simultaneous and independent articulation of flexion/extension, lateral bending, anterior/posterior translation, and axial rotation, the artificial disc (30) provided these four simultaneous and independent articulations by independently addressing each type of articulation in the design of the artificial disc (30). In one example, an artificial disc (30) is comprised of a bearing (40) disposed between first and second end plates (36, 38). The bearing (40) is movable relative to each end plate (36, 38), independent of the other end plate. The end plates (36, 38) are affixed to adjacent vertebrae by pegs (32) extending through holes in the end plates and being fixed in the holes.

Surgical cable system and method

Nucleotide analogs

Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolysed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for the synthesis and use are described.

Dust collector for grinders

Curable aliphatic epoxy-polimide compositions

A prepolymer is comprised of the reaction product of at least one aliphatic bismaleimide, at least one aromatic amine and at least one aromatic bismaleimide in combination with an aliphatic epoxy resin providing at least two functional epoxy groups to provide a low temperature curable composition. The cured products are flexible and strongly adherent to a variety of substrates.

Nucleotide analogs

Nucleotide phosphonate esters characterized by the presence of an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise an ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for their synthesis and use are described.

Nucleotide analogs

Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolysed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for the synthesis and use are described.

Bone Plate with Rings

Embodiments disclosed herein provide a plating system including a bone plate, a bone screw and a ring. The bone screw preferably connects the bone plate to a bone, and the ring preferably fixes the bone screw into a borehole of the bone plate such that the bone screw extends from the bone plate at a selected angle. The ring is preferably capable of swiveling within the borehole to allow the bone screw to be angulated at a plurality of angles oblique to the plate. The bone screw may have a head having a tapered, threaded surface for engaging the ring. The ring preferably has threading on its inner surface for mating with the threading on the head. The inner surface of the ring may be tapered. Movement of the head through the ring preferably expands the ring against the bone plate to fix the bone screw at a selected angle relative to the bone plate.

Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines

2122365 9310820 PCTABS00022 Novel oligomers are disclosed which have enhanced ability with respect to forming duplexes or triplexes compared with oligomers containing only conventional bases. The oligomers contain the bases 5-(1-propynyl)uracil, 5-(1-propynyl)cytosine or related analogs. The oligomers of the invention are capable of (i) forming triplexes with various target sequences such as virus or oncogene sequences by coupling into the major groove of a target DNA duplex at physiological pH or (ii) forming duplexes by binding to single-stranded DNA or to RNA encoded by target genes. The oligomers of the invention can be incorporated into pharmaceutically acceptable carriers and can be constructed to have any desired sequence, provided the sequence normally includes one or more bases that is replaced with the analogs of the invention. Compositions of the invention can be used as pharmaceutical agents to treat various diseases such as those caused by viruses and can be used for diagnostic purposes in order to detect viruses or disease conditions.

Pyrimidine derivatives for labeled binding partners

Compounds having particular interest as labels and various novel uses in diagnostics and therapeutics are provided which have structure (1) wherein R 1 is a binding partner, a linker or H; a and b are 0 or 1, provided that the total of a and b is 0 or 1; A is N or C; X is S, O, —C(O)—, NH or NCH 2 R 6 ; Y is —C(O)—; Z is taken together with A to form an aryl or heteroaryl ring structure comprising 5 or 6 ring atoms wherein the heteroaryl ring comprises a single O ring heteroatom, a single N ring heteroatom, a single S ring heteroatom, a single O and a single N ring heteroatom separated by a carbon atom, a single S and a single N ring heteroatom separated by a carbon atom, 2 N ring heteroatoms separated by a carbon atom, or 3 N ring heteroatoms at least two of which are separated by a carbon atom, and wherein the aryl or heteroaryl ring carbon atoms are unsubstituted with other than H or at least 1 nonbridging ring carbon atom is substituted with R 6 or ═O; R 6 is independently H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, NO 2 , N(R 3 ) 2 , C≡N or halo, or an R 6 is taken together with an adjacent R 6 to complete a ring containing 5 or 6 ring atoms; R 3 is a protecting group or H; and tautomers, solvates and salts thereof; and provided that where a is 0, b is 1, and R 1 is in which D 2 is independently hydroxyl, blocked hydroxyl, mono, di or triphosphate, or an oligodeoxyribonucleotide otherwise containing only the bases A, G, T and C; and D 3 is H or OH; then Z is not unsubstituted phenyl. Also provided are novel intermediates and methods for the preparation and use of the structure (1) compounds.

Spinal stabilization system insertion and methods

A spinal stabilization system (100) may be formed in a patient. In some embodiments, a minimally invasive procedure may be used to form a spinal stabilization system (100) in a patient. Bone fastener assemblies (102) may be coupled to vertebrae. Each bone fastener assembly (102) may include a bone fastener (108) and a collar (112). The collar (112) may be rotated and/or angulated relative to the bone fastener (108). Detachable members may be coupled to the collar (112) to allow for formation of the spinal stabilizati on system (100) through a small skin incision. The detachable members may allow for alignment of the collars (112) to facilitate insertion of an elongated member (104) in the collars (112). An elongated member (104) may be position ed in the collars (112) and a closure member (106) may be used to secure the elongated member (106) to the collars (112).

Curable aromatic epoxy-polyimide and cycloaliphatic epoxy-polyimide compositions

A prepolymer is comprised of the reaction product of at least one aliphatic bismaleimide, at least one aromatic amine and at least one aromatic bismaleimide in combination with an aromatic and/or a cycloaliphatic epoxy resin providing at least two functional epoxy groups to provide a low temperature curable composition. The cured products are strongly adherent to a variety of substrates.

Modified internucleoside linkages

Oligonucleotide analogs are disclosed wherein one or more phosphodiester linkages between adjacent nucleotides are replaced by a backbone linkage resistant to nucleases. The modified oligonucleotides are capable of strong hybridization to target RNA or DNA. These oligonucleotide analogs are useful in therapies which modulate gene expression using "antisense" or other specifically binding oligomers.

Collapsible bulk material container

A container assembly for bulk materials and a kit for assembling same are disclosed. A forming member having a plurality of sidewalk defines an internal cavity for receiving bulk materials. The sidewalk are arranged relative to one another and are locked into position so as to define a geometric volume of predetermined shape, by means of a locking assembly. The locking assembly ca n be integrally attached to or can be separable from the sidewalk, and can form a bottom of the container assembly. A tubular sleeve of continuous material is sized to snugly engage and overlie substantially the entire outer surface area of the sidewalls. The sleeve provides the containment strength, while the foaming member provides structural shape and stability to the container assembly. Additional layers of corrugated material or woven polypropylene material or their combination may be used as inserts engaging the inner peripheral sidewall areas of the forming member to provide additional strength to the container assembly. The forming member sidewalk may be freely slidable relative to one another or may be slidably affixed to one another by releasable glue.

nucleotide analogs

Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines

Novel oligomers are disclosed which have enhanced ability with respect to forming duplexes or triplexes compared with oligomers containing only conventional bases. The oligomers contain the base analog 5-propynyluracil, 5-propynylcytosine or related analogs. The oligomers of the invention are capable of (i) forming triplexes with various target sequences such as virus or oncogene sequences by coupling into the major groove of a target DNA duplex at physiological pH or (ii) forming duplexes by binding to single-stranded DNA or to RNA encoded by target genes. The oligomers of the invention may be constructed to have any desired sequence, provided the sequence normally includes one or more bases that is replaced with the analogs of the invention. Compositions of the invention can be used for diagnostic purposes in order to detect viruses or disease conditions.

Collapsible, reusable storage container

A collapsible, reusable bulk material container assembly, kit and method for assembling and using same are disclosed. Upper ring and base members are locked together by peripheral post members, forming an upright rigid framework that operatively supports a woven fabric bulk material receiving sleeve. A cover connected to the upper ring seals the container. Intermediate support bands may be attached to and along the post members to resist outwardly directed forces applied to the post members through the sleeve by contained bulk material. The container is reconfigurable to a collapsed storage or shipping module that retainably contains the post members, support bands and woven fabric sleeve. The post members may be segmentable or collapsible for containment within the collapsed module. Component parts of the container assembly are detachable, reusable and recyclable. One configuration of the container is sized to replace a conventional 55 gallon drum.

Tape reel positioning and latching means

This invention covers means in connection with magnetic recording devices, to position, latch and remove reels from a driving hub, and actuation means therefor. The hub onto which the tape reel is placed carries an elastic sleeve about which the reel is placed. An actuation rod which passes through the hollow shaft of the drive motor carries a spool, to which three link bars are hinged. These are in radial planes spaced at 120° to each other. The link bars are attached respectively to three shoes which are adapted to press outward against the inside wall of the elastic sleeve, which expanded outward against, and securely grips the reel hub. Also involved in the linkages between the link bars and the shoes are three dogs, which are adapted to press the reel hub against the drive hub and/or to lift the reel hub, depending on the position of the actuator rod. The actuator rod is adapted to be operated in push-pull fashion by a handle on the front face of the mechanism, or by means of a vacuum actuator mounted behind the reel drive motor.

Instruments and methods for reduction of vertebral bodies

Fusion methods using autologous stem cells

A method and apparatus is provided for use in spinal fusion procedures. An exemplary interbody fusion device includes a synthetic non-metallic radiolucent interbody spacer having an opening formed between its top and bottom surfaces. A cancellous allograft plug is configured to be disposed within the opening formed in the spacer. The cancellous allograft plug can be reconstituted with a material that will help to facilitate fusion of the vertebrae.

Surgical cable system

Occipito-cervical stabilization system and method

A system (10) and associated method are provided for mechanically fixating a region of a skull to a portion of a spine. A plate (20) is provided to contact a region of the skull and be secured thereto. A spinal rod (22) is configured to extend from a location adjacent the plate (20) to a location adjacent at least one vertebra (30). A variable connection (24) is provided to secure the rod (22) to the plate (20). The variable connection (24) has a first mode wherein the relative position of the rod (22) to the plate (20) can be adjusted and a second mode wherein the relative position of the rod (22) to the plate (20) is locked at a particular value selected to maintain a desired curvature of the spine.

Amidases and methods of their use

The disclosure relates to engineered amidase polypeptides and processes of using the polypeptides for chiral resolution of amino acid amide compounds. The disclosure further relates to the polynucleotides that encode the engineered amidase polypeptides and related vectors, host cells, and methods for making the engineered amidase polypeptides.

Spinal stabilization system insertion and methods

SURGICAL CABLE SYSTEM

A surgical cable system and method for securing surgical cable around a portion of a human element (e.g., bone) is described. The surgical cable system may include a connector and a tensioner. The connector may be adapted to hold a pin, positionable within the connector, such that the pin may secure the cable within the connector. The pin may be repositioned, after securing the cable, to allow the cable to move freely through the connector. The cable may be oriented within the connector such that the ends of the cable are perpendicular or parallel with respect to each other. The tensioner is preferably adapted to vary the tension of the cable. The cable may be passed through the connector, around a portion of a human bone, and back through the connector. The cable may be tensioned by use of the tensioner and secured into position within the connector. The connector may include a locking portion for engaging a protrusion formed on the pin. The engagement of the protrusion with the locking portion preferably inhibits rotation of the pin.

Binding competent oligomers containing 2', 5' linkages

The invention relates to novel modified oligonucleotides, the construction thereof, and their use in oligonucleotide-based therapies. More specifically, the invention is to novel oligonucleotides having modified internucleoside linkages which are resistant to nucleases, having enhanced ability to penetrate cells, and which are capable of binding target oligonucleotide sequences in vitro and in vivo. The modified oligonucleotides of the invention are particularly useful in oligonucleotide-based therapies utilizing the modified oligonucleotides to interrupt protein synthesis or transcription or to otherwise inactivate messenger RNA or double stranded DNA.

Bindungskompetente oligomere, die 2',5'-bindungen enthalten

Pyrimidinderivate als markierte bindungspartner

Gesteigerte bildung von triple- und doppelhelices aus oligomeren mit modifizierten pyrimidinen

Chirurgisches kabelsystem

Portable-platform wagon-jack.

Verfahren zur Herstellung von Benzimidazolderivaten

Spinal plate system for stabilizing a portion of a spine

A spinal plate system that maintains intervertebral spacing and spinal stability is provided. One embodiment includes a spacer (134, 136, 334) for establishing an initial condition of an adjustable spinal device (30) . The spacer includes a first coupling portion (154, 156, 336, 337) configured to couple selectively with a first segment (32) of the adjustable spinal device, a second coupling portion (148, 152, 338, 339) configured to couple selectively with a second segment (34) of the adjustable spinal device, and a spacer body (150, 310) extending between the first coupling portion and the second coupling portion. The spacer prevents movement of the first segment of the spinal device relative to the second segment when the first coupling portion is coupled selectively with the first segment and the second coupling portion is coupled selectively with the second segment.

Holding fixture for buick dynaflow transmissions

Bis(benzil) type compounds containing one or two furan moieties

A monomeric bis (benzil) composition is produced by reacting furfural with an aromatic dialdehyde, the product having the structure: ##STR1## wherein R is a difunctional aromatic radical, R' is a hydrogen, a phenylene, or a furan radical, and R" is a hydrogen or or an alkyl substituent. These monomers are used to prepare cross-linked polyquinoxaline resins which have enhanced thermal and mechanical properties. Polymerization of these bis(benzil) monomers occurs by the reaction of the carbonyl groups with a tetraamine monomer. Cross-linking of the resulting polymers chains is accomplished by reaction of the furan end-cap group in a Diels-Alder reaction with a bis(dieneophile) substantially aromatic in composition.

Paddle wheel

An improved means of lifting and lowering curtain poles and curtain attachments

An improved means of lifting and lowering curtain poles and curtain attachments

Vorrichtung zum Bedrucken von Flaschen

Verfahren zur Herstellung von N-Halogen-N'-phenylamidinen

Crosslinked polyquinoxaline polymers

Crosslinked polymers are produced by the reaction of a linear polyquinoxaline containing a pendant furan group with an aromatic olefinic end-capped compound. The polyquinoxaline polymers have an alicyclic endooxy linkage repeated throughout the polymer at the cross-linking sites where the furan end-capped constituent undergoes a Diels-Alder reaction with the aromatic olefinic endcapped crosslinking agent. Subsequently, the alicyclic endooxy linkage may be aromatized by the application of heat to produce a high performance polymer which is suitable for use in severe environments at temperatures up to 400*C.

Spinal fusion device and associated methods

A method and apparatus is provided for use in spinal fusion procedures. An exemplary interbody fusion device (10) includes a synthetic non-metallic radiolucent interbody spacer (12) having an opening formed between its top and bottom surfaces. A cancellous allograft plug (14) is configured to be disposed within the opening formed in the spacer (12). The cancellous allograft plug (14) can be reconstituted with a material that will help to facilitate fusion of the vertebrae.

Grain-elevator and wagon-dump.