21-01-2021 дата публикации
Номер: US20210017251A1
Принадлежит:
Disclosed herein is an amyloid β accumulation and/or aggregation inhibitor. A technique for inhibiting amyloid β accumulation and/or aggregation by concurrently introducing Nurr1 and Foxa2 genes and introducing the co-expression of the genes is also provided. When used, the composition can be applied to the prevention or treatment of a neurodegenerative disease caused by amyloid β accumulation and/or aggregation, such as Alzheimer's disease. 122.-. (canceled)23. A method for inhibiting amyloid β accumulation and/or aggregation in a subject , comprising the step of:administering to the subject a therapeutically effective amount of a composition comprising Nurr1 and Foxa2 genes, wherein the administration inhibits amyloid β accumulation.24. The method of claim 23 , wherein the Nurr1 and Foxa2 genes are carried by a vector.25. The method of claim 24 , wherein the vector is viral vector.26. The method of claim 25 , wherein the viral vector comprises an adeno-associated virus claim 25 , lentivirus claim 25 , adenovirus claim 25 , herpes virus claim 25 , retrovirus claim 25 , vaccinia virus claim 25 , or poxvirus vector.27. The method of claim 24 , wherein the vector is a non-viral vector.28. The method of claim 26 , wherein the non-viral vector comprises a plasmid claim 26 , RNA molecule claim 26 , or lipofection vector.29. The method of claim 23 , wherein the composition comprises neurons claim 23 , neuronal stem cells claim 23 , or glia claim 23 ,and wherein the Nurr1 and Foxa2 genes have been introduced into the neurons, neuronal stem cells, or glia.30. The method of claim 26 , wherein the glia are astrocytes or microglia.31. The method of claim 23 , wherein the subject is a mammalian subject.32. The method of claim 23 , wherein the effective amount of the composition comprises from 5×10to 5×10viral genomes each of Nurr1 and Foxa2 per dose administered to the subject.33. The method of claim 23 , wherein the administration of the effective amount is directly to the ...
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