Improvements relating to cancer therapy

BACTERIAL NITROREDUCTASE FOR THE REDUCTION OF CB 1954 AND ANALOGUES THEREOF TO A CYTOTOXIC FORM

The invention provides a nitroreductase, obtainable from a bacterium having the following characteristics as exemplified by examples isolated from Escherichia coli B and Bacillus amyloliquifaciens: 1) it is flavoprotein having a molecular weight in therange 20-60 Kilodaltons; 2) it requires either NADH or NAD(P)H or analogu es thereof as a cofactor; 3) it has a Km for NADH or NAD(P)H in the range 1-100 .mu.M; and 4) it incapable of reducing either of both nitro groups of CB 1954 and ana- logues thereof to a cytotoxic form e.g. the hydroxylamine. The sequence of o ne such nitroreductase is shown in Seq. ID No. 1. The nitroreductase maybe conjugated to a tumour targeting agent such as a monoclonal antibody and used to convert prodrugs into active antitumour agents. Such prodrugs and drugs are also provided. ...

Tidal power generation apparatus and methods

A BACTERIAL NITROREDUCTASE GENE-PRODRUG SYSTEM

The system of the invention comprises: (i) a viral vector comprising a nucleotide sequence encoding a nitroreductase, which nitroreductase in capable of converting a prodrug into a cytotoxic drug; and (ii) a prodrug capable of being converted into a cytotoxic drug by the nitroreductase encoded by the vector.

DNA MOLECULE ENCODING NITROREDUCTASE

PROBLEM TO BE SOLVED: To provide a DNA molecule effectively converting a prodrug into antitumor agent. SOLUTION: There are provided isolation of the DNA having a broad substrate specificity compared with known nitrodecuctase (EC.1.6.99.2) and encoding a new nitroreductase obtained from Escherichia coli B (wherein the nitroreductase is a flavoprotein having a molecular weight about 24 Kilodaltons) and a system of chemical treatment for tumor comprising use of the nitroreductase conjugated to a targeting agent such as a monoclonal antibody which will bind a tumor-associated antigen. COPYRIGHT: (C)2005,JPO&NCIPI ...

VERBESSERTE KREBSTHERAPIE

Vermin poison

Disclosed are: i) the use of an orally or nasally available formulation of Tretazicar for poisoning vermin, ii) an orally available or nasally available formulation of Tretazicar, wherein in the orally available formulation the Tretazicar is protected from acid hydrolysis, and provided that the formulation is not solid Tretazicar in a gelatin capsule, iii) a formulation of Tretazicar in which the Tretazicar is protected from acid hydrolysis, wherein the formulation is present in a liquid form iv) a combination of Tretazicar and bait, and v) a method of poisoning vermin comprising making available to the vermin an orally or nasally available formulation of Tretazicar and allowing the vermin to ingest or inhale the formulation of Tretazicar.

Tidal power generation apparatus and methods

An underwater turbine system comprises a support frame and a plurality of vertical axis turbines mounted in a two-dimensional array on the support frame. The apparatus includes horizontal flow deflectors 40 which controllably adjust flow into or out of the turbine array. The apparatus may also comprise at least one vertically extending flow deflector 34. The arrangement may be shaped to allow e.g. trawling fishing gear to slide over it without damaging the turbines or becoming entangled with the system.

IMPROVED CANCER THERAPY

PROCEDURE FOR THE FIGHT AGAINST INFECTIONS

Methods and compounds for detecting cancer

The invention relates to a method for diagnosing cancer, particularly bladder or prostate cancer using compounds of general formula (I): wherein R ...

Novel products and system including such prodrugs

METHODS AND COMPOUNDS FOR DETECTING CANCER

The invention relates to a method for diagnosing cancer, particularly bladder or prostate cancer using compounds of general formula (I): wherein R1, R2, R3, R4, R5 X, Y and z are as defined herein.

Tidal power generation system and methods

The invention provides a system for the extraction of energy from an underwaterflow stream in a body of water. The system comprises a support frame which comprises a plurality of receptacles for mounting functional modules on the support frame. The plurality of receptacles are arranged to form a horizontally-distributed two-dimensional array on the support frame. The plurality of vertical axis turbine units is configured to be interchangeably mounted in the receptacles.

VERBESSERTE KREBSTHERAPIE

BACTERIAL NITROREDUKTASE FOR THE REDUCTION OF CB 1954 AND SIMILAR ONE OF IT INTO A CYTOTOXIC FORM

Vermin poison

Use of an orally or nasally available formulation of Tretazicar for poisoning vermin. An orally available or nasally available formulation of Tretazicar, wherein in the orally available formulation the Tretazicar is protected from acid hydrolysis, and provided that the formulation is not solid Tretazicar in a gelatin capsule. A formulation of Tretazicar in which the Tretazicar is protected from acid hydrolysis, wherein the formulation is present in a liquid form. A combination of Tretazicar and bait. A method of poisoning vermin comprising making available to the vermin an orally or nasally available formulation of Tretazicar and allowing the vermin to ingest or inhale the formulation of Tretazicar.

VERMIN POISON

Use of an orally or nasally available formulation of Tretazicar for poisoning vermin. An orally available or nasally available formulation of Tretazicar, wherein in the orally available formulation the Tretazicar is protected from acid hydrolysis, and provided that the formulation is not solid Tretazicar in a gelatin capsule. A formulation of Tretazicar in which the Tretazicar is protected from acid hydrolysis, wherein the formulation is present in a liquid form. A combination of Tretazicar and bait. A method of poisoning vermin comprising making available to the vermin an orally or nasally available formulation of Tretazicar and allowing the vermin to ingest or inhale the formulation of Tretazicar.

System and method for cathodic protection of a subsea well-assembly

Abstract SYSTEM AND METHOD FOR CATHODIC PROTECTION OF A SUBSEA WELL-ASSEMBLY Disclosed herein is a subsea well assembly; wherein in an example embodiment the subsea well assembly includes an umbilical attached to a power source. The power source can be on a platform. Also included is a connector for connecting the umbilical to a receptacle included with the subsea well assembly and a subsea control module delivering power and control signals to the subsea well assembly. An impressed current protection module is integrated in the subsea control module that receives power from the umbilical.

Bacterial nitroreductase for the reduction of CB 1954 and analogues thereof to a cytotoxic form

Inducible cell ablation

A BACTERIAL NITROREDUCTASE GENE-PRODRUG SYSTEM

The system of the invention comprises: (i) a viral vector comprising a nucle otide sequence encoding a nitroreductase, which nitroreductase in capable of converting a prodrug into a cytotoxic drug; and (ii) a prodrug capable of being converted into a cytoto xic drug by the nitroreductase encoded by the vector.

Vermin poison

Use of an orally or nasally available formulation of Tretazicar for poisoning vermin. An orally available or nasally available formulation of Tretazicar, wherein in the orally available formulation the Tretazicar is protected from acid hydrolysis, and provided that the formulation is not solid Tretazicar in a gelatin capsule. A formulation of Tretazicar in which the Tretazicar is protected from acid hydrolysis, wherein the formulation is present in a liquid form. A combination of Tretazicar and bait. A method of poisoning vermin comprising making available to the vermin an orally or nasally available formulation of Tretazicar and allowing the vermin to ingest or inhale the formulation of Tretazicar.

Vermin poison

Improvements relating to cancer therapy

Methods and compounds for detecting cancer

The invention relates to a method for diagnosing cancer, particularly bladder or prostate cancer using compounds of general formula (I): wherein R ...

Novel prodrugs and system including such prodrugs

METHODS AND COMPOUNDS FOR DETECTING CANCER

The invention relates to a method for diagnosing cancer, particularly bladder or prostate cancer using compounds of general formula (I): 2. The method as claimed in wherein claim 1 , in the case where the bladder or prostate cancer cells over-express or are suspected of over-expressing NQO1 claim 1 , adding an NQO1 co-substrate to the sample.3. The method as claimed in wherein z comprises a chromophore or luminophore.4. The method as claimed in wherein z comprises a fluorescent claim 3 , phosphorescent claim 3 , chemiluminescent or bioluminescent marker such that z-XH or z-X is a fluorescent claim 3 , phosphorescent claim 3 , chemiluminescent or bioluminescent molecule or ion; or a modulator of emissions from a fluorescent claim 3 , phosphorescent claim 3 , chemiluminescent or bioluminescent molecule or ion; or a co-factor for a chemiluminescent or bioluminescent reaction.5. The method as claimed in wherein the optical properties of the moiety z change when it is cleaved from the remainder of the compound of general formula (I) to form the compound z-XH or the ion z-X.6. The method as claimed in claim 5 , wherein the change in optical properties of moiety z comprise a detectable change in the wavelength of emitted light claim 5 , the removal of a quenching effect exerted by the quinone moiety of general formula (I) or claim 5 , in the case of co-factors claim 5 , a modulation of their activity.7. The method as claimed in wherein the moiety z comprises a detectable particle claim 1 , for example a coloured latex microparticle claim 1 , gold nanoparticle or magnetic particle.8. The method as claimed in wherein the moiety z comprises a binding portion which selectively binds a capture moiety wherein capture moiety comprises a binding partner for the moiety z.9. The method as claimed in wherein one of the moiety z and the capture moiety is an antigen and the other is an antibody; or where one of z and the capture moiety is biotin or a biotin derivative and the other is ...

BAKTERIELLE NITROREDUKTASE ZUR REDUZIERUNG VON CB 1954 UND ANALOGEN DAVON IN EINE ZYTOTOXISCHE FORM

System and method for cathodic protection of a subsea well-assembly

Disclosed herein is a subsea well assembly; wherein in an example embodiment the subsea well assembly includes an umbilical attached to a power source. The power source can be on a platform. Also included is a connector for connecting the umbilical to a receptacle included with the subsea well assembly and a subsea control module delivering power and control signals to the subsea well assembly. An impressed current protection module is integrated in the subsea control module that receives power from the umbilical.

SYSTEM AND METHOD FOR CATHODIC PROTECTION OF A SUBSEA WELL-ASSEMBLY

SYSTEM AND METHOD FOR CATHODIC PROTECTION OF A SUBSEA WELL-ASSEMBLYAbstract of the Disclosure Disclosed herein is a subsea well assembly; wherein in an example embodiment the subsea well assembly includes an umbilical attached to a power source. The power source can be on a platform. Also included is a connector for connecting the umbilical to a receptacle included with the subsea well assembly and a subsea control module delivering power and control signals to the subsea well assembly. An impressed current protection module is integrated in the subsea control module that receives power from the umbilical.Figure 2 ...

MODULAR TIDAL POWER GENERATION SYSTEM AND METHODS FOR ITS USE.

System and Method for Cathodic Protection of a Subsea Well-Assembly

Disclosed herein is a subsea well assembly; wherein in an example embodiment the subsea well assembly includes an umbilical attached to a power source. The power source can be on a platform. Also included is a connector for connecting the umbilical to a receptacle included with the subsea well assembly and a subsea control module delivering power and control signals to the subsea well assembly. An impressed current protection module is integrated in the subsea control module that receives power from the umbilical. 1. A subsea well assembly comprising:an umbilical connected to a power source on a platform;a connector for connecting the umbilical to a receptacle in the subsea well assembly;a subsea control module delivering power and control signals to the subsea well assembly; andan impressed current protection module integrated in the subsea control module, the impressed current protection module receiving power from the umbilical.2. A wellhead assembly of claim 1 , wherein the subsea control module further includes:a power pack having the inductor disposed therein, the power pack adapted to receive the alternating current signal from the umbilical and adapted to deliver power to components in the subsea control module;a subsea electronics module, powered by the power pack, the subsea electronics module monitoring various measurements in the wellhead assembly, including temperatures and pressures of various hydraulic lines and actuating directional control valves to control a flow of hydraulic fluid through the lines and valves of the well assembly and delivering power to the impressed current protection module.3. A wellhead assembly of claim 2 , wherein the subsea control module further includes:a fluid reservoir, connected to the directional control valves and a pump, the fluid reservoir supplying hydraulic fluid to the wellhead assembly, the fluid reservoir having outlet lines and return lines.4. A wellhead assembly of claim 3 , wherein the anode is fabricated ...

Solar energy concentrator

A solar concentrator assembly comprises a segmented wave-guide assembly, a reflective mirror assembly, and an optical target-providing unit. A segmented waveguide assembly comprises a plurality of wave-guide segments, each segment comprising a set of surfaces disposed so as to support TIR propagation of solar energy and a turn mirror affixed thereto and disposed to receive solar energy from a mirror of the reflective mirror assembly and reflect said solar energy into the wave-guide segment at angles compatible with TIR propagation. The reflective mirror assembly comprises a plurality of mirrors each being aligned to reflect the solar energy to a turn mirror affixed to each wave-guide segment. The optical target providing unit converts solar energy from the light propagated in the wave-guide assembly to a different form of energy.

Efficient solar energy concentrator with improved thermal management

A solar concentrator comprises a reflective curved mirror assembly, a support riser placed to support and position photovoltaic cells attached to a printed circuit board that is in turn attached to a heat sink at the focal point of the mirrors of the reflective curved mirror assembly. A central support riser may grasp the assembly of photovoltaic cells attached to a printed circuit board while other support risers may allow the assembly of photovoltaic cells to move slightly to accommodate differences in the coefficient of thermal expansion between the mirror assembly and the printed circuit board and the heat sink. The solar concentrator may include a prism assembly placed to separate solar radiation angularly by wavelength to facilitate use of single junction photovoltaic cells for increased efficiency. The heat sink may form the major structural element of the solar concentrator. 1. A solar concentrator assembly comprising a plurality of reflector mirrors with gain in two axes arrayed in at least one line ,a plurality of photovoltaic cells affixed to a circuit board,a heat sink disposed so as to collect and dissipate excess heat generated by the plurality of photovoltaic cells arrayed on a circuit board,support means suitable for supporting and aligning the plurality of photovoltaic cells affixed to a circuit board attached to a heat sink assembly such that at least one photovoltaic cell is proximate to the focal point of each reflector mirror, andmeans for collecting the electric energy generated by said set of photovoltaic cells.2. The solar concentrator assembly of wherein the at least one line of reflector mirrors forms a major structural element of the assembly claim 1 , andthe at least one line of reflector mirrors comprising a plurality of mirrors and support elements for said plurality of photovoltaic cells affixed electrically and mechanically to a circuit board.3. The solar concentrator assembly of wherein the heat sink assembly forms a major structural ...

CLIENT SERVER COMMUNICATION SYSTEM

Apparatus for communicating with a server application. A first request is received by a first agent application on a first client computer system from the server application to request that a second agent application on a second client computer system communicate with the server application. Responsive to receiving the first request, a second request is sent by the first agent application to the second agent application on the second client computer system to communicate with the server application. 17-. (canceled)8. A computer system comprising:a bus system;a storage device connected to the bus system;a processor unit; andprogram code stored on the storage device, wherein the processor unit is configured to process the program code to receive a first request from a server application to request to instruct an agent application on a client computer system to communicate with the server application and send a second request to the agent application on the client computer system to communicate with the server application in response to receiving the request.9. The computer system of claim 8 , wherein in being configured to process the program code to send the second request claim 8 , the processor unit is configured to process the program code to send the second request to a listening socket used by the agent application on the client computer system.10. The computer system of claim 8 , wherein the second request includes an address for the server application.11. The computer system of claim 8 , wherein in being configured to process the program code to send the second request claim 8 , the processor unit is configured to process the program code to identify an address for the agent application from the first request and send the second request to the address for the agent application.12. The computer system of claim 8 , wherein the processor unit further processes the program code to send a polling request to the server application and send contact information and ...

CLIENT SERVER COMMUNICATION SYSTEM

A method for communicating with agent applications. A first request is sent by a server application on a server computer system to a first agent application to communicate with the server application. The first agent application is located in a first network. If the first agent application fails to respond to the first request, a second request is sent by the server application to a second agent application to instruct the first agent application to communicate with the server application. The first agent application is located on a first client computer system that is in a zone with a second client computer system on which the second agent application is located. 3. The method of further comprising:receiving addresses from the agent applications when the agent applications contact the server application, wherein the addresses are used by the server application to contact the agent applications.4. The method of claim 1 , wherein client computer systems are selected for the zone such that second agent application is able to communicate with the first agent application when the first agent application fails to respond to the first request.5. The method of claim 1 , wherein client computer systems are selected for the zone such that the client computer systems are configured to communicate with each other without communications going through a firewall.6. The method of claim 1 , wherein the first agent application polls the server application after a polling interval passes; listens to a listening socket for the first request; and polls the server application in response to detecting the first request at the listening socket even if the polling interval has not occurred.720-. (canceled) This application is a continuation of application Ser. No. 13/172,919 filed Jun. 30, 2011, status pending.1. Field of the InventionThe present disclosure relates generally to network data processing systems and, in particular, to a method and apparatus for communications between a ...

CLIENT SERVER COMMUNICATION SYSTEM

A method for communicating with a server application. A first request is received by a first agent application on a first client computer system from the server application to request that a second agent application on a second client computer system communicate with the server application. Responsive to receiving the first request, a second request is sent by the first agent application to the second agent application on the second client computer system to communicate with the server application. 1. A method for communicating with a server application , the method comprising:receiving, by a first agent application on a first client computer system, a first request from the server application to request to instruct a second agent application on a second client computer system to communicate with the server application; andresponsive to receiving the first request, sending, by the first agent application, a second request to the second agent application on the second client computer system to communicate with the server application.2. The method of claim 1 , wherein the sending step comprises:sending the second request to a listening socket used by the second agent application on the second client computer system.3. The method of claim 1 , wherein the second request includes an address for the server application.4. The method of claim 1 , wherein the sending step comprises:identifying an address for the second agent application from the first request; andsending the second request to the address for the second agent application.5. The method of further comprising:sending a polling request to the server application; andsending contact information and identity information to the server application.6. The method of further comprising:authenticating the first request from the server application; andresponsive to an absence of the authentication of the first request as being from the server application, preventing the sending of the second request to the second agent ...

Two-Axis Solar Concentrator System

A system for use on a surface to collect solar energy from the sun has a stand, a module, and solar collector(s). The stand supportable on the surface has rotational points rotatably supporting the module so it can rotate about a first axis of rotation. A first drive disposed on the stand is operable to provide first rotation, and a cable connected between a hoop pulley of the module and the first drive on the stand can rotate the module about the first axis to direct the solar collector(s) toward the sun. The solar collector(s) disposed on the module can be photovoltaic cells for collecting solar energy. A second drive on the module can rotate an adjacent solar collectors on the module using pulleys and cable. Reflectors on the collectors can focus the sun rays to photovoltaic cells. The second drive can rotate the collectors about a second axis, carried by the first axis, to direct the solar collector(s) toward the sun. 1. A system for use on a surface to collect solar energy from the sun , the system comprising:a stand supportable on the surface and having first opposing ends, the first opposing having first rotation points;a frame having second opposing ends with second rotational points, the second rotational points rotatably disposed on the first rotational points of the stand, the frame rotatable on the first and second rotational points about a first axis of rotation;a first drive disposed on the stand and operable to provide first rotation;a hoop disposed on the frame and defining a curvature about the first axis;at least one first cable connected between the hoop and the first drive and rotating the frame about the first axis with the hoop in response to the first rotation of the first drive; andsolar collector means affixed to the frame.2. The system of claim 1 , wherein the at least one first cable comprises a pre-stretched wire cable.3. The system of claim 1 , wherein the first drive comprises an encoder claim 1 , a stepper motor claim 1 , a linear ...

METHOD FOR LOGGING OF A REMOTE CONTROL SESSION

A method for logging of a remote control session, for use in a remote control system comprising a session initiator operable to initiate a remote control session having a session identifier between a first computer and a second computer and a generator for generating a secure data structure comprising a data structure identifier, the method comprising the steps of: in response to generation by the generator of the secure data structure, initiating an associated first remote control session having a first session identifier; capturing data associated with a remote control function executable by a first computer for control of the second computer during the remote control session; obtaining the data structure identifier; and using the data structure identifier and the first session identifier to store the captured data in the secure data structure associated with the remote control session. 116.-. (canceled)17. A method for logging data associated with a remote control session , comprising:scraping, by a hardware processor of a computer, a screen buffer upon accepting initiation of the remote control session;handling a command for correcting an error received upon a user interacting with an application executing on the computer;capturing command data associated with both the command and also data associated with processing the command, where the command data includes on-screen activity associated with the command, an identifier associated with the command, and annotation data indicating data associated with the error and a successful fix; and,transmitting the command data to a hardware processor of a second computer.18. The method of claim 17 , wherein scraping the screen buffer further comprises sending data scraped from the screen buffer to a first remote control application of a third computer.19. The method of claim 17 , wherein handling the command comprises:sending a request to initiate a capture of command data associated with the command and data associated ...

Tidal Power Generation System and Methods

The invention provides a system for the extraction of energy from an underwaterflow stream in a body of water. The system comprises a support frame which comprises a plurality of receptacles for mounting functional modules on the support frame. The plurality of receptacles are arranged to form a horizontally-distributed two-dimensional array on the support frame. The plurality of vertical axis turbine units is configured to be interchangeably mounted in the receptacles. 1. A system for the extraction of energy from an underwater flow stream in a body of water , the system comprising:a support frame comprising a plurality of receptacles for mounting functional modules on the support frame, the plurality of receptacles arranged to form a horizontally-distributed two-dimensional array on the support frame; anda plurality of vertical axis turbine units configured to be interchangeably mounted in the receptacles.2. The system according to claim 1 , comprising at least one functional module configured to be interchangeably mounted in the receptacles.3. The system according to claim 1 , wherein the plurality of vertical axis turbine units is arranged substantially in a horizontal plane.4. The system according to claim 1 , wherein the plurality of vertical axis turbines is arranged with a subset of the vertical axis turbines vertically offset with respect to others of the plurality of vertical axis turbines.5. The system according to claim 1 , wherein one or more receptacles comprises an energy storage module.6. The system according to claim 1 , wherein one or more receptacles comprises an accumulator cell module.7. The system according to claim 1 , wherein one or more receptacles comprises a hydrogen fuel cell module.8. The system according to claim 1 , wherein one or more receptacles comprises a control module.9. The system according to wherein the support frame and plurality of vertical axis turbines units form an integrated assembly configured to be towed to an ...

USE OF ALPHA-HYDROXY CARBONYL COMPOUNDS AS REDUCING AGENTS

There is provided the use as reducing agents of alpha-hydroxycarbonyl compounds capable of forming cyclic dimers. There is also provided corresponding methods of reducing reducible compounds, particularly reduction-activated prodrugs. Examples of the alpha-hydroxycarbonyl compounds used are dihydroxyacetone, glycolaldehyde, glyceraldehyde, erythrose, xylulose, erythrulose or 3-hydroxy-2-butanone. 172-. (canceled)73: A topical pharmaceutical composition comprising 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide and a topically-acceptable adjuvant , diluent or carrier.74: The topical pharmaceutical composition according to claim 73 , wherein the composition is a solution or suspension.75: The topical pharmaceutical composition according to claim 74 , wherein the solution or suspension is sprayable.76: The topical pharmaceutical composition according to claim 73 , wherein the composition is a cream claim 73 , lotion or ointment.77: A dry powder aerosol composition comprising 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide.78: A therapeutic system comprising:(a) a dry powder inhalation device, and{'claim-ref': {'@idref': 'CLM-00077', 'claim 77'}, '(b) one or more discrete doses of the dry powder aerosol composition according to .'}79: The therapeutic system according to claim 78 , wherein the dry powder inhalation device contains a source of propellant gas.80: A device that is:(a) a mechanical sprayer having a reservoir loaded with a solution or suspension comprising 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide and a pharmaceutically-acceptable adjuvant, diluent or carrier; or(b) an aerosol device comprising a solution or suspension comprising one or more propellant gases and 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide and a pharmaceutically-acceptable adjuvant, diluent or carrier. The present invention relates to the use of certain compounds as reducing agents. In particular, it relates to the use of those compounds to reduce a reduction-activated ...

Two-Axis Solar Concentrator System

A system for use on a surface to collect solar energy from the sun has a stand, a module, and solar collector(s). The stand supportable on the surface has rotational points rotatably supporting the module so it can rotate about a first axis of rotation. A first drive disposed on the stand is operable to provide first rotation, and a cable connected between a hoop pulley of the module and the first drive on the stand can rotate the module about the first axis to direct the solar collector(s) toward the sun. The solar collector(s) disposed on the module can be photovoltaic cells for collecting solar energy. A second drive on the module can rotate an adjacent solar collectors on the module using pulleys and cable. Reflectors on the collectors can focus the sun rays to photovoltaic cells. The second drive can rotate the collectors about a second axis, carried by the first axis, to direct the solar collector(s) toward the sun. 1. A system for use on a surface to collect solar energy from the sun , the system comprising:a stand supportable on the surface and having first opposing ends, the first opposing ends having first rotational points;a module having second opposing ends with second rotational points, the second rotational points rotatably disposed on the first rotational points of the stand, the module rotatable on the first and second rotational points about a first axis of orientation;a first drive disposed on the stand and operable to provide first rotation;a hoop disposed on the module and defining a curvature about the first axis;at least one first cable connected between the hoop and the first drive and rotating the module about the first axis with the hoop in response to the first rotation of the first drive; andone or more solar collectors disposed on the module for collecting solar energy.2. The system of claim 1 , wherein the at least one first cable comprises a pre-stretched wire cable.3. The system of claim 1 , wherein first drive comprises a motor claim ...

VERMIN POISON

Use of an orally or nasally available formulation of Tretazicar for poisoning vermin. An orally available or nasally available formulation of Tretazicar, wherein in the orally available formulation the Tretazicar is protected from acid hydrolysis, and provided that the formulation is not solid Tretazicar in a gelatin capsule. A formulation of Tretazicar in which the Tretazicar is protected from acid hydrolysis, wherein the formulation is present in a liquid form. A combination of Tretazicar and bait. A method of poisoning vermin comprising making available to the vermin an orally or nasally available formulation of Tretazicar and allowing the vermin to ingest or inhale the formulation of Tretazicar. 1. A formulation of Tretazicar , other than solid Tretazicar in a gelatin capsule ,wherein the Tretazicar is orally available and the Tretazicar is protected from acid hydrolysis, orwherein the Tretaizcar is nasally available.2. The formulation of wherein the Tretazicar is protected from acid hydrolysis claim 1 , and the formulation is in a liquid form.3. The formulation of wherein the Tretazicar is encapsulated or coated.4. The formulation of wherein the Tretazicar is encapsulated in microcapsules.5. The formulation of wherein the microcapsules comprise a component selected from gelatin claim 4 , starch claim 4 , waxes claim 4 , cellulose acetate phthalate claim 4 , polyvinyl acetate phthalate claim 4 , hydroxypropyl methylcellulose phthalate claim 4 , hydroxypropyl methylcellulose acetate succinate claim 4 , methacrylic acid copolymers and mixtures thereof.6. A combination of Tretazicar and bait.7. The combination of which is inhalable.8. The combination of which is orally ingestible.9. The combination of wherein the bait comprises a foodstuff.10. The combination of wherein the composition is edible by a rodent.11. The combination of wherein the Tretazicar is protected from acid hydrolysis.12. The combination of comprising a solution of Tretazicar mixed with the bait. ...

USE OF ALPHA-HYDROXY CARBONYL COMPOUNDS AS REDUCING AGENTS

There is provided the use as reducing agents of alpha-hydroxycarbonyl compounds capable of forming cyclic dimers. There is also provided corresponding methods of reducing reducible compounds, particularly reduction-activated prodrugs. Examples of the alpha-hydroxycarbonyl compounds used are dihydroxyacetone, glycolaldehyde, glyceraldehyde, erythrose, xylulose, erythrulose or 3-hydroxy-2-butanone. 172-. (canceled)73. A topical pharmaceutical composition comprising 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide and a topically-acceptable adjuvant , diluent or carrier.74. The topical pharmaceutical composition according to claim 73 , wherein the composition is a solution or suspension.75. The topical pharmaceutical composition according to claim 74 , wherein the solution or suspension is sprayable.76. The topical pharmaceutical composition according to claim 73 , wherein the composition is a cream claim 73 , lotion or ointment.77. A dry powder aerosol composition comprising 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide.78. A therapeutic system comprising:(a) a dry powder inhalation device, and{'claim-ref': {'@idref': 'CLM-00077', 'claim 77'}, '(b) one or more discrete doses of the dry powder aerosol composition according to .'}79. The therapeutic system according to claim 78 , wherein the dry powder inhalation device contains a source of propellant gas.80. A device that is:(a) a mechanical sprayer having a reservoir loaded with a solution or suspension comprising 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide and a pharmaceutically-acceptable adjuvant, diluent or carrier; or(b) an aerosol device comprising a solution or suspension comprising one or more propellant gases and 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide and a pharmaceutically-acceptable adjuvant, diluent or carrier.81. A method of combating undesirable growth or proliferation of cells in an individual in need thereof claim 73 , wherein the method comprising administering to the ...

Faceted light pipe

A light pipe used for backlighting liquid crystal displays has a planar front surface and a stairstepped or faceted back surface. Light is injected from the ends of the light pipe from cold or hot cathode, apertured, fluorescent lamps. The cold cathode lamps are preferably insulated to raise their operating temperature. The back surface has a series of planar portions parallel to the front surface connected by facets, which are angled so that the injected light reflects off the facets and through the front surface. A reflector having a planar, highly reflective, highly scattering surface or a sawtoothed or grooved upper surface is located adjacent to and parallel with the light pipe back surface to reflect light escaping from the back surface back through the light pipe to exit the front surface. The axis of grooves is preferably slightly skewed from the facet axis to reduce moire pattern development. A low scattering or loss diffuser is located adjacent to and parallel with the light pipe front surface to reduce moire pattern development. The liquid crystal display is located over the low scattering diffuser. A separate injector may be located between the lamp and the light pipe to better couple the light into the light pipe.

Projecting images the invention relates to projecting images

Method of combating infection

A method of combating a parasitic protozoal infection of a host organism, the method comprising administering tretazicar to the host organism. Tretazicar is the compound 5-(aziridin-l-yl)-2,4-dinitrobenzamide (CB 1954), and the parasitic infection is preferably an infection of Trypanosoma cruzi, T. b. brucei, Leishmania spp. particularly L. infantum, Cryptosporidium or Giardia spp.

Multiplexed display element sequential color LCD panel

In a color sequential system using LCDs, the LCD must operate faster than the frame rate because red, green, and blue are done sequentially. Ferroelectric LCDs can do this, but they are not analog devices and so cannot provide analog display levels. Instead, a pulse width modulation (PWM) technique is used. In the system of the present invention, each pixel has three storage devices to hold RGB analog levels. A latch is used to load these values in parallel. Then an analog 3:1 multiplexer is used to select the proper storage device for the current sequential color. The multiplexer output goes to a comparator, which has a sawtooth waveform input at much faster than the frame rate. The comparator output changes with the sawtooth level, so that PWM control is provided for each pixel. As an alternative, standard analog LCD pixels can be sequentially switched between three color input storage devices.

Software installation in data processing network

Bacterial nitroreductase for the reduction of cb 1954 and analogues thereof to a cytotoxic form

The invention provides a nitroreductase, obtainable from a bacterium having the following characteristics as exemplified by examples isolated from Escherichia coli B and Bacillus amyloliquifaciens: 1) it is flavoprotein having a molecular weight in therange 20-60 Kilodaltons; 2) it requires either NADH or NAD(P)H or analogues thereof as a cofactor; 3) it has a Km for NADH or NAD(P)H in the range 1-100 νM; and 4) it is capable of reducing either or both nitro groups of CB 1954 and analogues thereof to a cytotoxic form e.g. the hydroxylamine. The sequence of one such nitroreductase is shown in Seq. ID No. 1. The nitroreductase may be conjugated to a tumour targeting agent such as a monoclonal antibody and used to convert prodrugs into active antitumour agents. Such prodrugs and drugs are also provided.

Graphic user interface for computer networking

Projecting images

An "extra-folded" projection display system includes a selectively reflective material (e.g., a linear reflecting polarizer) placed immediately behind the system's imaging screen. The display system includes an image projector that projects an image beam containing light of a predetermined linear polarization toward the imaging screen. The linear reflecting polarizer reflects the light in the image beam away from the screen. The reflected image beam then encounters a 1/4-wavelength achromatic retarder which converts the linear polarization to circular polarization. The image beam next hits a mirror that reflects the light back through the 1/4-wavelength achromatic retarder, which converts the circular polarization back to linear polarization, with the polarization director rotated 90° from the original polarization director. The linear reflecting polarizer then allows the light to pass through to the image screen.

Use of alpha-hydroxy carbonyl compounds as reducing agents

Faceted light pipe

FACETED LIGHT PIPE Abstract of the Disclosure A light pipe used for backlighting liquid crystal displays has a planar front surface and a stairstepped or faceted back surface. Light is injected from the ends of the light pipe from cold or hot cathode, apertured, fluorescent lamps. The cold cathode lamps are preferably insulated to raise their operating temperature. The back surface has a series of planar portions parallel to the front surface connected by facets, which are angled so that the injected light reflects off the facets and through the front surface. A reflector having a planar, highly reflective, highly scattering surface or a sawtoothed or grooved upper surface is located adjacent to and parallel with the light pipe back surface to reflect light escaping from the back surface back through the light pipe to exit the front surface. The axis of grooves is preferably slightly skewed from the facet axis to reduce moire pattern development. A low scattering or loss diffuser is located adjacent to and parallel with the light pipe front surface to reduce moire pattern development. The liquid crystal display is located over the low scattering diffuser. A separate injector may be located between the lamp and the light pipe to better couple the light into the light pipe.

Projection screen apparatus

Therapeutic systems for activation prodrugs

A compound comprising a target cell-specific portion and human NAD(P)H:quinone reductase 2 (NQO2) or a variant or fragment or fusion or derivative thereof which has substantially the same activity as NQO2 towards a given prodrug, or a polynucleotide encoding said NQO2 or said variant or fragment or fusion or derivative. A recombinant polynucleotide comprising a target cell-specific promoter operably linked to a polynucleotide encoding human NAD(P)H:quinone reductase 2 (NQO2) or a variant or fragment or fusion or derivative thereof which has substantially the same activity as NQO2 towards a given prodrug. The compounds and polynucleotides are useful in a method of treating a patient in conjunction with a suitable prodrug. A method of treating a human patient with a target cell to be destroyed wherein the target cell expresses NQO2 the method comprising administering to the patient a prodrug which is converted to a substantially cytotoxic drug by the action of NQO2 and nicotinamide riboside (reduced) (NRH) or an analogue thereof which can pass reducing equivalents to NQO2.

Image projection system engine assembly

A light projection engine uses a wide angle reflecting polarizer material (preferably 3M DBEF brand double brightness enhancement filter) as a polarizing beamsplitter to direct polarized light to beam splitter/combiner (such as an X-cube dichroic reflector). The beam splitter/combiner then splits the directed polarized light into separate reflective LCD panels acting as light valves. The LCD panels alter the polarity of the incident light from 0 degrees up to 90 degrees to control which light is passes from the wide angle reflecting polarizer back towards the light source and which light has the necessary polarization change to allow it to pass from the wide angle reflecting polarizer to the lens system. After reflecting off of the LCD panels, the light goes back through the X-cube dichroic reflector, where it is recombined. The recombined light which is of a first polarity is transmitted from the reflecting polarizer to the lens system, while the recombined light which is of a second polarity is transmitted to the light source. The LCDs are preferably analog polarizing LCDs.

Method of combating infection

Method of combating infection

A method of combating a parasitic protozoal infection of a host organism, the method comprising administering tretazicar to the host organism. Tretazicar is the compound 5-(aziridin-l-yl)-2,4-dinitrobenzamide (CB 1954), and the parasitic infection is preferably an infection of Trypanosoma cruzi, T. b. brucei, Leishmania spp. particularly L. infantum, Cryptosporidium or Giardia spp.

5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide

There is provided the use as reducing agents of alpha-hydroxycarbonyl compounds capable of forming cyclic dimers. There is also provided corresponding methods of reducing reducible compounds, particularly reduction-activated prodrugs. Examples of the alpha-hydroxycarbonyl compounds used are dihydroxyacetone, glycolaldehyde, glyceraldehyde, erythrose, xylulose, erythrulose or 3-hydroxy-2-butanone.

Bacterial nitroreductase for the reduction of cb 1954 and analogues thereof to a cytotoxic form

The invention provides a nitroreductase, obtainable from a bacterium having the following characteristics as exemplified by examples isolated from Escherichia coli B and Bacillus amyloliquifaciens: 1) it is flavoprotein having a molecular weight in therange 20-60 Kilodaltons; 2) it requires either NADH or NAD(P)H or analogues thereof as a cofactor; 3) it has a Km for NADH or NAD(P)H in the range 1-100 µM; and 4) it incapable of reducing either of both nitro groups of CB 1954 and ana-logues thereof to a cytotoxic form e.g. the hydroxylamine. The sequence of one such nitroreductase is shown in Seq. ID No. 1. The nitroreductase maybe conjugated to a tumour targeting agent such as a monoclonal antibody and used to convert prodrugs into active antitumour agents. Such prodrugs and drugs are also provided.

Methods and compounds for detecting cancer

High efficiency lamp apparatus for producing a beam of polarized light

An electrodeless lamp apparatus of high efficiency employs a reflection system that allows the lamp to reabsorb light energy. The energy is redirected back to the light to provide increased system efficiency. The redirected light is of the wrong polarization and/or wrong parts of the color spectrum. The lamp efficiency is increased because of the optical pumping as well as the reuse (after some downshifting) of the returned light. In one embodiment, a projection system provides an image source or projection engine that includes the improved high efficiency lamp of the present invention.

Well subsurface safety valve

A hydraulically actuated well subsurface safety valve having a tubular member telescopically movable in the housing for controlling the movement of a flapper valve closure member in which a seal is telescopically movable in the housing and positioned in the path of travel of the lower end of the tubular member for sealing against the lower end of the tubular member. A spring urges the seal towards the tubular member for sealing when the valve is in the open position for limiting damaging fluid flow across the valve closure member.

Tidal power generation system and methods

The invention provides a system for the extraction of energy from an underwaterflow stream in a body of water. The system comprises a support frame which comprises a plurality of receptacles for mounting functional modules on the support frame. The plurality of receptacles are arranged to form a horizontally-distributed two-dimensional array on the support frame. The plurality of vertical axis turbine units is configured to be interchangeably mounted in the receptacles.

Projecting images

An "extra-folded" projection display system includes a selectively reflective material (e.g., a linear reflecting polarizer) placed immediately behind the system's imaging screen. The display system includes an image projector that projects an image beam containing light of a predetermined linear polarization toward the imaging screen. The linear reflecting polarizer reflects the light in the image beam away from the screen. The reflected image beam then encounters a 1/4-wavelength achromatic retarder which converts the linear polarization to circular polarization. The image beam next hits a mirror that reflects the light back through the 1/4-wavelength achromatic retarder, which converts the circular polarization back to linear polarization, with the polarization director rotated 90° from the original polarization director. The linear reflecting polarizer then allows the light to pass through to the image screen.

High efficiency electrodeless lamp apparatus with frit sealed ceramic reflecting housing that contains a plasma light source

Data processing network

Data processing network with boot process using multiple servers

A data processing network has a client connected to first and second servers in which the first and second servers are operable to communicate with the network according to first and second incompatible data communication protocols. The client is operable to issue, onto the network, a first initial boot request (e.g. RPL) according to the first data communication protocol (IEEE 802.2) and the first server is operable, in response to the client request to send BOOTP bootstrap code to the client system. The BOOTP bootstrap code is loaded into client memory and when executed causes the client to issue a BOOTP request for servicing by the second server system.

Faceted light pipe

Functionalised metallocenes as anticancer drugs

Human quinone reductase 2 conjugates for adept and gdept

A compound comprising a target cell-specific portion and human NAD(P)H:quinone reductase 2 (NQO2) or a variant or fragment or fusion or derivative thereof which has substantially the same activity as NQO2 towards a given prodrug, or a polynucleotide encoding said NQO2 or said variant or fragment or fusion or derivative. A recombinant polynucleotide comprising a target cell-specific promoter operably linked to a polynucleotide encoding human NAD(P)H:quinone reductase 2 (NQO2) or a variant or fragment or fusion or derivative thereof which has substantially the same activity as NQO2 towards a given prodrug. The compounds and polynucleotides are useful in a method of treating a patient in conjunction with a suitable prodrug. A method of treating a human patient with a target cell to be destroyed wherein the target cell expresses NQO2 the method comprising administering to the patient a prodrug which is converted to a substantially cytotoxic drug by the action of NQO2 and nicotinamide riboside (reduced) (NRH) or an analogue thereof which can pass reducing equivalents to NQO2.

Electrodeless lamp with sealed ceramic reflecting housing

An electrodeless lamp (10) for producing an intense beam of light includes a concave lamp body (11) that surrounds the lamp interior. A gas, such as sulfur or selenium or compounds thereof, is contained within the lamp body (11) for forming a plasma light source. The concave lamp body (11) has a reflecting surface (12). Electrodes (27, 28) are disposed external to the lamp body for producing radio frequency energy for exciting the gas. A heat resistant glass plate (20) seals the concave lamp body (11). A frit seal (23) can be used for forming a pressure and temperature resistant seal between the concave lamp body (11) and the glass plate (20). The light beam generated by the plasma exists through the glass plate (20).

Two-axis solar concentrator system

A system for use on a surface to collect solar energy from the sun has a stand, a module, and solar collector(s). The stand supportable on the surface has rotational points rotatably supporting the module so it can rotate about a first axis of rotation. A first drive disposed on the stand is operable to provide first rotation, and a cable connected between a hoop pulley of the module and the first drive on the stand can rotate the module about the first axis to direct the solar collector(s) toward the sun. The solar collector(s) disposed on the module can be photovoltaic cells for collecting solar energy. A second drive on the module can rotate an adjacent solar collectors on the module using pulleys and cable. Reflectors on the collectors can focus the sun rays to photovoltaic cells. The second drive can rotate the collectors about a second axis, carried by the first axis, to direct the solar collector(s) toward the sun.

Bacterial nitroreductase for the reduction of CB 1954 and analogues thereof to a cytotoxic form

The invention provides a nitroreductase, obtainable from a bacterium having the following characteristics as exemplified by examples isolated from Escherichia coli B and Bacillus amyloliquifaciens: 1) it is flavoprotein having a molecular weight in the range of 20-60 Kilodaltons; 2) it requires either NADH or NAD(P)H or analogues thereof as a cofactor; 3) it has a Km for NADH or NAD(P)H in the range of 1-100 μM; and 4) it is capable of reducing either or both nitro groups of CB1954 and analogues thereof to a cytotoxic form e.g. the hydroxylamine. The sequence of one such nitroreductase is shown in Seq. ID No. 1. The nitroreductase may be conjugated to a tumor targeting agent such as a monoclonal antibody and used to convert prodrugs into active antitumor agents. Such prodrugs and drugs are also provided.

Therapeutic systems

Methods of forming localized positive optical power units a substrate

Screen apparatuses are provided which include a first lens or holographic optical element layer and a second mask layer. The first layer substantially collimates image light rays to impinge on the mask layer. The mask layer provides an array or matrix of projecting members. Each of the projecting members receives and focuses the substantially collimated light rays to corresponding focal points. The mask layer includes a mask that blocks light transmission except where openings are located. The openings allow the light focused through the focal joints to substantially pass through the mask to form an image. The screen apparatuses can be advantageously employed in display apparatuses.

IMPROVEMENTS RELATED TO CANCER THERAPY.

EL SISTEMA DE LA INVENCION COMPRENDE: I) UN VECTOR VIRAL QUE COMPRENDE UNA SECUENCIA DE NUCLEOTIDO QUE CODIFICA UNA NITRORREDUCTASA, LA NITRORREDUCTASA ES CAPAZ DE CONVERTIR UNA PRODROGA EN UNA DROGA CITOTOXICA; Y II) UNA PRODROGA CAPAZ DE SER CONVERTIDA EN UNA DROGA CITOTOXICA MEDIANTE LA NITRORREDUCTASA CODIFICADA POR EL VECTOR.

Projection of images

5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide

There is provided the use as reducing agents of alpha-hydroxycarbonyl compounds capable of forming cyclic dimers. There is also provided corresponding methods of reducing reducible compounds, particularly reduction-activated prodrugs. Examples of the alpha-hydroxycarbonyl compounds used are dihydroxyacetone, glycolaldehyde, glyceraldehyde, erythrose, xylulose, erythrulose or 3-hydroxy-2-butanone.

Automatic network protocol configuration in a data processing system

A data processing network comprises a plurality of client systems and a controlling system which transmits "broadcast" data packets which may be received by any of the client systems attached to the network. The client system, on initial connection to the network, analyses the transmitted "broadcast" data packets and determines the network protocols in use on the network. The client system then configures software located at the client system so as to use one of the network protocols in use on the network. Furthermore, the client system customises the operating parameters it uses to communicate with the network so as to optimise the performance of communication with the network. Additionally, the client systems may, optionally, analyse transmitted non-broadcast data packets.

Method of combating infection

A method of combating a parasitic protozoal infection of a host organism, the method comprising administering tretazicar to the host organism. Tretazicar is the compound 5-(aziridin-l-yl)-2,4-dinitrobenzamide (CB 1954), and the parasitic infection is preferably an infection of Trypanosoma cruzi, T. b. brucei, Leishmania spp. particularly L. infantum, Cryptosporidium or Giardia spp.

Use of alpha-hydroxy carbonyl compounds as reducing agents

There is provided the use as reducing agents of alpha-hydroxycarbonyl compounds capable of forming cyclic dimers. There is also provided corresponding methods of reducing reducible compounds, particularly reduction-activated prodrugs . Examples of the alpha-hydroxycarbonyl compounds used are dihydroxyacetone, glycolaldehyde , glyceraldehyde, erythrose, xylulose, erythrulose or 3-hydroxy-2-butanone.

Solar energy concentrator

A solar concentrator assembly comprises a stepped wave-guide assembly, a reflective mirror assembly, and an optical target providing unit. The stepped wave-guide assembly includes at least one surface, comprising a set of parallel but offset adjacent surfaces, and an opposing surface. The wave-guide assembly propagates light in a total internal reflection mode between the at least one surface and the opposing surface. The wave-guide assembly also includes transition surfaces between the adjacent parallel surfaces and the transition surfaces include edges perpendicular to a longitudinal axis of the wave-guide assembly. The reflective mirror assembly includes a plurality of mirrors each being aligned to reflect the light to one of the transition surfaces between two of the parallel adjacent surfaces. The optical target providing unit converts solar energy from the light propagated in the wave-guide assembly to a different form of energy.

Contrast polymer dispersed liquid crystal projection display system

A polymer dispersed liquid crystal projection display is provided that has enhanced contrast. In the projection system using a polymer dispersed liquid crystal display (PDLC), polarized light is used as the light source onto the PDLC. The reflected light maintains its polarization, while the scattered light from the off pixels of the PDLC randomize the polarization. The polarized image is then passed through a polarizing filter which eliminates half of the scattered light, whereas practically all of the polarized image is passed onto the display source. In this way, the contrast between the on and off pixels is effectively doubled.

Vermin poison

Use of an orally or nasally available formulation of Tretazicar for poisoning vermin. An orally available or nasally available formulation of Tretazicar, wherein in the orally available formulation the Tretazicar is protected from acid hydrolysis, and provided that the formulation is not solid Tretazicar in a gelatin capsule. A formulation of Tretazicar in which the Tretazicar is protected from acid hydrolysis, wherein the formulation is present in a liquid form. A combination of Tretazicar and bait. A method of poisoning vermin comprising making available to the vermin an orally or nasally available formulation of Tretazicar and allowing the vermin to ingest or inhale the formulation of Tretazicar.

Cooling-off period for destructive software

In a computer system, a user action can cause a computer program to perform actions which may destroy data stored on the computer or on an associated computer. User actions are managed to reduce this possibility by testing the consequences of the user action and if the consequences of the user action are benign, the user action is completed. If the consequences are not benign, a delay period prior to completing the user action is initiated. During this delay period, the user is able to cancel the user action.

Projection screen apparatus

Screen apparatus (30) provided which includes a first lens layer (31) and a second mask layer (75). The first layer collimates light (35) to impinge on the mask layer (75). The mask layer (75) provides an array of projecting members (78, 79, 80, 81). Each of the projecting members (78, 79, 80, 81) receives and focuses the substantially collimated light rays (35) to corresponding focal points. The mask layer (75) includes a mask (86) that blocks light transmission except where openings (87, 88, 89, 90, 91) are located. The openings (87, 88, 89, 90, 91) allow the light focused (92) through the focal points to pass through the mask (86) to form an image.

gerador de energia de corrente e mÉtodo para gerar energia elÉtrica

GERADOR DE ENERGIA DE CORRENTE E MÉTODO PARA GERAR ENERGIA ELÉTRICA Um sistema de conduto de lama elétrico (10) que inclui uma montagem do tipo turbina de geração de energia (10) que pode ser abaixada através de um cabo de perfilagem e instalada no leito do mar ou conduto de lama (12). Um gerador (16) pode ser instalado sobre uma cabeça de poço (14)para suporte e o mesmo é localizado sobre uma parte inferior da montagem de geração (10) ou pode ser instalado através de uma árvore, se um tampão sobre a árvore for removido. Uma armação (20) é incluída para fornecer suporte adicional para a montagem de geração (10) e para proteger as pás de hélice da turbina (27) na periferia da turbina (26). A turbina (26) gira em resposta às correntes marítimas e, através disto, gira um eixo (28) acoplado à turbina (26) para gerar a energia elétrica. A energia elétrica é gerada de forma local ao poço para energizar vários tipos de equipamento (50) no poço ou ao lado do poço.

Verfahren zur bekämpfung von infektionen

Συζυγη ανθρωπινης ρεδουκτασης 2 κινονης για adept και gdept

Εδώ περιγράφεται μια ένωση περιλαμβάνουσα ένα ειδικό προς ένα κύτταρο-στόχο τμήμα και ανθρώπινη ρεδουκτάση 2 ΝΑD(Ρ)Η:κινόνης (NQO2) ή ένα παράλλαγμα ή θραύσμα ή σύντηξη ή παράγωγο αυτής η οποία ουσιαστικά έχει την ίδια ενεργότητα με την NQO2 προς ένα δεδομένο προφάρμακο, ή ένα πολυνουκλεοτίδιο που κωδικεύει τη ρηθείσα NQΟ2 ή το ρηθέν παράλλαγμα ή θραύσμα ή σύντηξη ή παράγωγο. Ένα ανασυνδυασμένο πολυνουκλεοτίδιο περιλαμβάνον έναν ειδικό προς ένα κύτταρο-στόχο προαγωγέα λειτουργικώς συνδεδεμένο σε ένα πολυνουκλεοτίδιο που κωδικεύει την ανθρώπινη ρεδουκτάση 2 ΝΑD(Ρ)Η:κινόνης (NQO2) ή ένα παράλλαγμα ή θραύσμα ή σύντηξη ή παράγωγο αυτής το οποίο ουσιαστικά έχει την ίδια ενεργότητα με την NQΟ2 προς ένα δεδομένο προφάρμακο. Οι ενώσεις και τα πολυνουκλεοτίδια είναι χρήσιμα σε μια μέθοδο αγωγής ενός ασθενή σε συνδυασμό με ένα κατάλληλο προφάρμακο. Μια μέθοδος αγωγής ενός ανθρώπου ασθενή με ένα κύτταρο-στόχο που πρόκειται να καταστραφεί όπου το κύτταρο-στόχος εκφράζει την NQΟ2 όπου η μέθοδος περιλαμβάνει τη χορήγηση στον ασθενή ενός προφαρμάκου το οποίο μετατρέπεται σε ένα ουσιαστικά κυτταροτοξικό φάρμακο διά της δράσης της NQΟ2 και ριβοζίτη νικοτιναμιδίου (ανηγμένος) (NRH) ή ενός αναλόγου αυτού το οποίο μπορεί να περάσει αναγωγικά ισοδύναμα στην NQO2.

Menschliche chinon reduktase konjugate für adept und gdept

Lichtleitung mit facettenstruktur

Subsea energy storage and method of use

The invention provides a modular system and method of use for the storage of energy subsea. The modular system comprises an energy management system and a rechargeable energy storage system. The energy management system is configured to control a transfer of electrical energy between the rechargeable energy storage system and at least one energy source and/or at least one electrical load.

Subsea Energy Storage and Method of Use

A modular system and method of use for the storage of energy subsea comprises an energy management system and a rechargeable energy storage system 11. The energy management system is configured to control a transfer of electrical energy between the rechargeable energy storage system and at least one energy source 12 and/or at least one electrical load 20, 21. The rechargeable energy storage system may comprise at least one battery. The energy source may comprise a renewable or non renewable energy source, an electric grid, a turbine, a vessel, a wave energy converter, a tidal energy converter, an ocean current converter, an ocean thermal energy converter or a solar panel system. The load may comprise a wind farm grid, underwater vehicle, electrolyser, subsea pump or subsea hydraulic power unit.

Verbesserte krebstherapie

Cooling-off period for destructive software

Bakterielle nitroreduktase zur reduzierung von cb 1954 und analogen davon in eine zytotoxische form

Method for logging of a remote control session

A method for logging of a remote control session, for use in a remote control system comprising a session initiator operable to initiate a remote control session having a session identifier between a first computer and a second computer and a generator for generating a secure data structure comprising a data structure identifier, the method comprising the steps of: in response to generation by the generator of the secure data structure, initiating an associated first remote control session having a first session identifier; capturing data associated with a remote control function executable by a first computer for control of the second computer during the remote control session; obtaining the data structure identifier; and using the data structure identifier and the first session identifier to store the captured data in the secure data structure associated with the remote control session.

Digital display driven by analog interface with reduced noise

Electrical mudline system

An that includes a turbine-type power generation assembly that can be lowered by wireline and installed at the seabed or mudline. A generator may be installed on a wellhead for support and located on a lower part of the generation assembly or may be installed through a tree if a cap on the tree is removed. A frame is included to provide additional support for the generation assembly and protect the turbine blades on the periphery of the turbine. The turbine rotates in response to water currents and thereby rotates a shaft coupled to the turbine to generate electrical power. The electrical power is generated local to the well to power various types of equipment at the well or in the vicinity of the well.

Electrical mudline system

Apparatus for blooming filter tow

Apparatus for blooming filter tow

Initial program load in data processing network

A client is arranged so that at power up it makes a request to a server for first boot code which allows the client to boot from its own mass storage. Since the OS is not sent from the server over the network, traffic flow is eased whilst strict control of client software type is maintained. The configuration of a client may be checked prior to software, particularly OS, installation by a server. The server, detecting a new client on the network, down-loads scan code onto the client. The client then runs the scan code and returns hardware configuration data to the server. If the OS of the client is to be modified then the server sends different, second boot code to the client which instructs the client to boot (a new OS) directly from the server. The OS from the server is then installed on the client mass storage device, and subsequent IPLs take place using the first boot code.

Apparatus for applying plasticizer to filter tow

Improvements relating to the control of neoplastic tissue growth

Inducible cell ablation

The present invention provides a method of producing a transgenic non-human animal, which method comprises incorporating into the genome of the non-human animal at least one nucleotide sequence (A) comprising a sequence (i) encoding a nitroreductase which is capable of converting a prodrug into a cytotoxic drug.

Compensation for DC balancing of liquid crystal displays

In a reflective mode FLC application, a ¼-wave plate compensating FLC is used in series with a ¼-wave imaging FLC to compensate for the effects of DC balancing. Alternatively, the compensating wave plate could be any odd ¼-wave multiple, such as 3λ/4, 5λ/4, etc. The FLCs are driven in synchronization between on and off states with the total effective retardation for each FLC being either none or one-half wavelength in a double pass.

Apparatus for applying plasticizer to filter tow

Subsea energy storage and method of use

The invention provides a modular system and method of use for the storage of energy subsea. The modular system comprises an energy management system and a rechargeable energy storage system. The energy management system is configured to control a transfer of electrical energy between the rechargeable energy storage system and at least one energy source and/or at least one electrical load.

Use of alpha-hydroxy carbonyl compounds as reducing agents

There is provided the use as reducing agents of alpha-hydroxycarbonyl compounds capable of forming cyclic dimers. There is also provided corresponding methods of reducing reducible compounds, particularly reduction-activated prodrugs. Examples of the alpha-hydroxycarbonyl compounds used are dihydroxyacetone, glycolaldehyde, glyceraldehyde, erythrose, xylulose, erythrulose or 3-hydroxy-2-butanone.

Method for logging of a remote control session

A method for logging of a remote control session, for use in a remote control system comprising a session initiator operable to initiate a remote control session having a session identifier between a first computer and a second computer and a generator for generating a secure data structure comprising a data structure identifier, the method comprising the steps of: in response to generation by the generator of the secure data structure, initiating an associated first remote control session having a first session identifier; capturing data associated with a remote control function executable by a first computer for control of the second computer during the remote control session; obtaining the data structure identifier; and using the data structure identifier and the first session identifier to store the captured data in the secure data structure associated with the remote control session.

Client server communication system

Apparatus for communicating with a server application. A first request is received by a first agent application on a first client computer system from the server application to request that a second agent application on a second client computer system communicate with the server application. Responsive to receiving the first request, a second request is sent by the first agent application to the second agent application on the second client computer system to communicate with the server application.

Client server communication system

Apparatus for communicating with agent applications. A first request is sent by a server application on a server computer system to a first agent application to communicate with the server application. The first agent application is located in a first network. If the first agent application fails to respond to the first request, a second request is sent by the server application to a second agent application to instruct the first agent application to communicate with the server application. The first agent application is located on a first client computer system that is in a zone with a second client computer system on which the second agent application is located.