03-08-2017 дата публикации
Номер: US20170216290A1
Disclosed are chemical entities which are compounds of formula (I): 2. The chemical entity of claim 1 , wherein:{'sub': '2', 'claim-text': (i) a 5-membered heteroaryl or a 6-membered aryl or heteroaryl to form a bicyclic group; or', {'sub': 1-4', '1-4', '1-4', '1-4', '1-4', '1-4', '2', '2', '2', '2', '2', '2', '2', '2', '2, 'sup': z7', 'z8', 'z8', 'z8', 'z7', 'z7', 'z7', 'z7', 'z7', 'z8', 'z7', 'z8', 'z7', 'z8', 'z9, '(ii) a 9-membered heteroaryl or a 10-membered aryl or heteroaryl to form a tricyclic group; wherein the ring system is optionally substituted by 1-3 independent occurrences of halogen, hydroxyl, cyano, Caliphatic, Cfluoroaliphatic, Calkoxy, Cfluoroalkoxy, —S—Caliphatic, —S—Cfluoroaliphatic, —N(R), —C(O)R, —S(O)R, —S(O)R, —C(O)R, —C(O)N(R), —S(O)N(R), —OC(O)N(R), —N(R)C(O)R, —N(R)SOR, —N(R)C(O)OR, T-R, a 5- to 6-membered heteroaryl, a 6-membered aryl, a 3- to 6-membered cycloaliphatic, or a 4- to 6-membered heterocyclyl; and the ring system is optionally substituted at one saturated carbon with oxo, a spirocyclic 3- to 6-membered carbocycle, or a spirocyclic 4- to 6-membered heterocycle;'}], '(a) Zis a ring system having a 5- to 7-membered heterocyclyl with 1-2 heteroatoms or a 5- to 7-membered cycloaliphatic fused to'}{'sup': 'z7', 'sub': '1-4', 'each occurrence of Ris independently hydrogen or Calkyl;'}{'sup': 'z8', 'sub': '1-4', 'each occurrence of Ris independently Calkyl;'}{'sub': 2', '1-2, 'Tis a Calkylene chain;'}{'sup': z9', 'z7', 'z7', 'z8', 'z7', 'z7, 'sub': 2', '2', '2, 'claim-text': OR', {'sub': '2', 'sup': 'e', 'claim-text': {'sup': 'e', 'sub': 3', '1-4', '1-4, '(i) Ris hydrogen, hydroxyl, halogen, —CF, or Caliphatic optionally substituted with one or more hydroxyl, halogen, or Caliphatic,'}, '(b) Zis L-Rwherein either, {'sup': e', 'f', 'f′, 'claim-text': {'sup': e', 'e', 'z7', 'z8', 'z8', 'z8', 'z7', 'z7', 'z7', 'z7', 'z7', 'z8', 'z7', 'z8', 'z7', 'z8', 'z9, 'sub': 1-4', '1-4', '1-4', '1-4', '1-4', '1-4', '2', '2', '2', '2', '2', '2', '2', ...
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