05-06-2014 дата публикации
Номер: US20140155387A1
Автор:
CHOI GAHEE,
HAN SUNG-JUN,
KANG Sunhee,
KIM Jaeseung,
KIM Jeongjun,
Kim Jung Hwan,
Lee Jinhwa,
LEE Saeyeon,
Lee Sangchul,
NAM KIYEAN,
NO Zaesung,
Park Young Sam,
SEO Min Jung
Принадлежит:
The present invention refers to: a compound having the general formula (I), wherein n is 0, 1, 2 or; m is 0, 1, 2 or 3; o is 0, 1, 2 or 3; W, X, Y and Z are independently selected from CH, N or N-oxide; A is NR, C═O, C═S, OP(O)(O), P═O, CH, or a heteroarly selected from the group consisting of (a), (b), (c), (d), (e), (f), (g); V is C═O, O, S, CH, or NR; as well as its use in treating inflammatory diseases such as asthma, COPD, inflammation post infection, arthritis, atherosclerosis, pain and dermatitis. 2. The method use according to claim 1 , wherein said compound has an inhibitory activity on an enzyme involved in an inflammatory pathway claim 1 , at a concentration of said compound between 0.01-30 μM claim 1 , having an ICon arachidonate 5-lipoxygenase of less than 1 μM and/or having an ECof less than 1 μM on the production of leukotriene B4 (LTB4) in peripheral blood mononuclear cells (PBMC).3. The method according to claim 1 , wherein said compound has one of the formulae 1-403 claim 1 , as shown in Tables 1-3 and/or Example 4 or a pharmaceutically acceptable salt thereof.4. The method according to claim 1 , wherein said compound has one of the formulae 127 claim 1 , 128 claim 1 , 189 claim 1 , 219 claim 1 , 224 claim 1 , 225 claim 1 , 232 claim 1 , 243 claim 1 , 265 claim 1 , 266 claim 1 , 299 claim 1 , 311 claim 1 , 312 claim 1 , 313 claim 1 , 314 claim 1 , 380 claim 1 , 393-396 and 398-403 as shown in Tables 2 and/or 3 claim 1 , or a pharmaceutically acceptable salt thereof.5. The method according to claim 1 , wherein said compound is in a composition that also comprises a pharmaceutically acceptable carrier.6. The method according to claim 1 , wherein said inflammatory disease is asthma claim 1 , arthritis claim 1 , dermatitis chronic obstructive pulmonary disease (COPD) claim 1 , inflammation post infection claim 1 , atherosclerosis claim 1 , or pain.79-. (canceled)10. The method according to claim 1 , wherein said effective amount is an amount in the ...
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