07-03-2013 дата публикации
Номер: US20130059900A1
Принадлежит:
A crystal form I of (S)-4-hydroxy-2-oxo-1-pyrrolidine acetamide, or named (S)-oxiracetam, is provided, which is characterized by a powder x-ray diffraction pattern that exhibits data of d-values versus the relative intensities as: 7.075(M), 5.355(S), 5.092(S), 4.590(M), 4.325(M), 4.259(S), 4.041(VS), 3.808(M), 3.542(M), 3.445(M), 3.393(M), 2.972(M), 2.914(S). A method for preparing a crystal form I of (S)-oxiracetam is also provided, which includes preparing the crude product and crystallizing A use of the crystal form I of (S)-oxiracetam in the manufacture of a medicament for preventing and treating memory dysfunction is also provided. Accordingly, the crystal form I of (S)-oxiracetam prepared by the method has high purity of more than 99.3% based on the percentages of the mass, with better efficacy than (S)-oxiracetam for preventing or treating memory dysfunction. Concerning the way of charging materials, adding inorganic base only a few times is simpler and more beneficial to industrial manufacturing and application. 3. The crystal form I of (S)-4-hydroxy-2-oxo-1-pyrrolidine acetamide as claimed in or , wherein it is characterized by a powder x-ray diffraction pattern with peaks at 12.500 , 13.940 , 15.000 , 16.540 , 17.400 , 19.320 , 20.520 , 20.840 , 21.980 , 23.340 , 25.120 , 25.840 , 26.240 , 27.660 , 28.100 , 30.040 , 30.660 , 31.040 , 31.780 , 34.300 , 35.180 , 37.060 , 38.020 , and 42.240 degrees in terms of 2θ.4. The crystal form I of (S)-4-hydroxy-2-oxo-1-pyrrolidine acetamide as claimed in claim 3 , wherein it is characterized by characteristic absorption bands obtained from infrared spectroscopy at peaks having the wavelengths (cm) as below:{'sub': O—H', 'N—H', 'C—H', 'C═O', 'CH2(scissoring)', 'O—H(in-plane bending)', 'N—H', 'C—O', 'N—H(out-of-plane bending), 'sup': −1', '−1', '−1', '−1', '−1', '−1', '−1', '−1', '−1', '−1', '−1, 'hydroxyl group (ν: 3403 cm), amido group (ν: 3355 cm, 3184 cm), methylene group (ν: 2926 cm, 2881 cm), carbonyl group (ν: ...
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