COPOLYMERS OF (METH) ACRYLOXY ALKYL SILOXYSILANE ONE AND ALKYL (METH) ACRYLATES AND THEIR USE AS PRESSURE-SENSITIVE ADHESIVES

CONTROLLED RELEASE DOSAGE FORM

The present invention generally relates to a pharmaceutical dosage form and controlled release of biologically active agents, diagnostic agents, reagents, cosmetic agents, and agricultural/insecticide agents. In one embodiment, the dosage form has a substrate that forms a compartment, wherein the substrate includes at least a first piece and a second piece, wherein the first piece operably links to the second piece. The dosage form contains a drug content that is loaded into the compartment. The dosage form also has a releaser operably linked to the substrate which upon contact with water or body fluid is capable of separating the first and second piece to open the compartment and release the drug content.

Ground nest breeding box

The invention provides a ground nest breeding box. The ground nest breeding box is composed of a hemispheric circular heat preservation cover, a cylindrical nest cavity, a porous separation plate, an anti-slip buckle plate type entry and exit channel and a sewage drainage channel. The hemispheric circular heat preservation cover is divided into an outer cover, a middle cover and an inner cover and locked and buckled to the cylindrical nest cavity through concave-convex openings in the edges. The cylindrical nest cavity is divided into an upper living cavity and a lower sanitizing cavity, the diameter of the sanitary cavity is smaller than that of the living cavity, the living cavity and the sanitizing cavity are separated through the porous separation plate, the bottom of the sanitizing cavity is provided with an inclined surface and connected with the sewage drainage channel through a sewage outlet, and an opening is formed in the other side of the cylindrical nest cavity and connected ...

Inhalable particle and fine particles's desorption device in flue gas

The utility model belongs to atmosphere pollution control field, concretely relates to inhalable particle and fine particles's desorption device in flue gas. The utility model discloses a device is including general dust remover, the one -level ash bucket, high gradient magnetic -type dust remover, second grade ash bucket and rapping device, the electro -magnet is installed to gas passage both sides in that high gradient magnetic -type dust remover is inside, magnetic matrix perpendicular to magnetic field direction and gas flow direction, the particulate matter of particle diameter >= 100 microns is deviate from to general dust remover when carrying out the particulate matter desorption, caught by magnetic matrix in remaining inhalable particle of containing and fine particles's the arbitrary high gradient magnetic -type dust remover of flue gas inflow. Utilize the device provided by the utility model, the conventional dust remover problem not good to inhalable particle removal effects ...

Method of using proteinase to diabetic foot gangrene

The invention relates to a method for treating diabetic foot gangrene by protease. According to the size of wound and the quantity of necrotic tissue, 0.1-0.5mg protease is arranged on the wound and flesh-engendering sticking paste or flesh-engendering Yuhong paste are externally applied; the medicine is replaced every 24 hours. The method can strengthen the dissolution effect of necrotic fascia tendons, i.e., the effect of removing rot; after the rot is removed, muscle (granulation tissue) is regenerated, which provides a relatively suitable growing condition for the healing of tissue. The treatment method is simple; the effect can be satisfactory; the cure rate can reach 67.3 percent and the total effective rate can reach 92.3 percent. The side effect of the method is small and patients suffer less pain.

Method for directionally separating antiendotoxic active monomer from a Chinese medicinal extract

The invention discloses a method for directionally separating an antiendotoxic active monomer from a Chinese medicinal extract. The method comprises the following steps of: adding the Chinese medicinal extract into a macroporous adsorption resin column, carrying out gradient elution on the Chinese medicinal extract with the solution of ethanol in water, and detecting the binding activity of all components obtained from elution with the Lipid A respectively to obtain a component A1 having the highest binding activity; adding the component A1 into a polyamide column, carrying out gradient elution on the component A1 with the solution of ethanol in water, and detecting the binding activity of all components obtained from elution with the Lipid A respectively to obtain a component B1 having the highest binding activity; separating the component B1 by adopting the high performance liquid chromatography, and detecting the binding activity of all components obtained from separation with the Lipid ...

Kit for detecting age-related macular degeneration and application thereof

The invention belongs to the technical field of biology, and particularly relates to a kit for detecting age-related macular degeneration and application of the kit. The kit comprises a primer combination, the primer combination comprises CFH-F1524, CFH-R1668, ARMS2-F359, ARMS2-R490, HTRA1-F1043 and HTRA1-R1119, and the nucleotide sequence of the primer combination is as shown in SEQ ID NO: 1 to 6. The invention further discloses a kit for detecting the content of the HRA1-F1043. The invention also provides an application of the primer combination in preparation of an age-related macular degeneration kit, and the kit has high sensitivity and specificity in detection of age-related macular degeneration, and plays an important role in detection, screening, prognosis evaluation or disease monitoring of age-related macular degeneration.

Separation and purification device for organic light-emitting material

According to the technical scheme, the organic light-emitting material separation and purification device is characterized by comprising a bottom block, a top groove is formed in the top face of the bottom block, an ultrasonic vibration plate is fixedly installed on the inner bottom face of the top groove, a bearing box is arranged in the top groove, and a supporting plate is fixedly installed on one side of the bottom block; during use, a separation and purification solution can be poured into the top tank, at the moment, a bearing box filled with organic light-emitting raw materials can be placed in the top tank, the purification solution is immersed into the bearing box through a metal net to be mixed with the organic light-emitting raw materials, and then an ultrasonic vibration plate is started to vibrate the purification solution to be fully mixed, so that the purification effect is improved; after purification, the bearing box can be pulled to rise to the position horizontal to the ...

Variable frequency drive circuit with overvoltage protection

A variable frequency drive (VFD) circuit includes an input connectable to an AC source, a rectifier to convert an AC power input to a DC power, a DC link to receive DC power from the rectifier and having a DC link voltage thereon, a DC link capacitor bank with one or more capacitors connected to the DC link, and a pre-charge circuit coupled to the DC link capacitor. The pre-charge circuit further includes one or more resistors, one or more pre-charge relays each operable in on and off states to selectively control a current flow through the resistor(s) so as to control an initial pre-charge of the DC link capacitor, and an overvoltage relay operable in on and off states to selectively cut-off a current flow to the DC link capacitor bank, so as to prevent an overvoltage condition in the DC link capacitor bank.

DOSAGE FORMS AND USE THEREOF

It relates to a stable solid pharmaceutical dosage form for oral administration. The dosage form includes a substrate that forms at least one compartment and a drug content loaded into the compartment. The dosage form is so designed that the active pharmaceutical ingredient of the drug content is released in a controlled manner.

Preparation method of organic titanium cross-linking agent for polyhydroxy alcohol fracturing fluid

The invention relates to a preparation method of an organic titanium cross-linking agent for polyhydroxy alcohol fracturing fluid. The preparation method comprises the following steps: adding alkali, sugar, divalent alcohol and tetrabutyl titanate into a reactor, uniformly mixing, raising temperature to 110-150 DEG C, keeping the temperature unchanged, performing reaction for 1-5 hours under continuous stirring, and getting golden yellow liquid which is the organic titanium cross-linking agent for the polyhydroxy alcohol fracturing fluid, wherein the alkali is sodium hydroxide, ethylenediamine, trimethylamine or triethanolamine; the sugar is monosaccharose or disaccharide, the monosaccharose is fructose or glucose, the disaccharide is sucrose, maltose or lactose; the divalent alcohol is ethylene glycol or propylene glycol; the weight ratio of the alkali to the sugar to the divalent alcohol is 0.01-0.2: 0.1-0.4: 1; and the weight ratio of the tetrabutyl titanate to the divalent alcoholis ...

Megawatt level composite material wind electricity blade vacuum guiding and forming technique

The invention discloses a vacuum infusion forming process for a megawatt grade composite material wind turbine blade. The process comprises a step of spreading and cladding reinforced material layers in an upper mold cavity and a lower mold cavity of a mould of the blade respectively and a step of solidification, demoulding and product forming, and is characterized by comprises the following steps between the two steps: 1)distributing injection systems on the surfaces of the reinforced material layers; 2) distributing vacuum systems on the outer surface of the injection systems spread and covered with flow channels in the step 1); 3) checking the airtight performance of an vacuumizing opening; 4) mould filling ( filling rubber liquid); and 5), solidification, demoulding and product forming. The vacuum infusion process can complete mould filling in 1.5 hours, improves the forming efficiency of large blades, saves special equipment and achieves low production costs. Products formed by the ...

CHOLESTERINREGULIERENDER COMPLEX FROM SIRT1 AND LXR AND ITS USE

3D printing device and method

A 3D printing device (100), comprising a melt extrusion module (102), a printing module (103), and a platform module (104). The melt extrusion module (102) comprises a processing chamber (121) consisting of a feed inlet (124) and a discharge outlet (125), as well as an extrusion means (122) and a heating means (123) disposed at the processing chamber; the melt extrusion module (102) is configured to receive an initial material from the feed inlet (124) of the processing chamber (121), and heat and extrude the initial material to convert the initial material into a molten body, which is extruded out of the discharge outlet (125) of the processing chamber (121). The printing module (103) is communicated with the discharge outlet (125) of the processing chamber (121) and is provided with a nozzle (131); the printing module (103) is configured to receive the molten body extruded from the discharge outlet (125) of the processing chamber (121) and guide the molten body to be extruded out of the ...

Controlled release dosage form

The present invention generally relates to a pharmaceutical dosage form and controlled release of biologically active agents, diagnostic agents, reagents, cosmetic agents, and agricultural/insecticide agents. In one embodiment, the dosage form has a substrate that forms a compartment, wherein the substrate includes at least a first piece and a second piece, wherein the first piece operably links to the second piece. The dosage form contains a drug content that is loaded into the compartment. The dosage form also has a releaser operably linked to the substrate which upon contact with water or body fluid is capable of separating the first and second piece to open the compartment and release the drug content.

Rainwater collecting and soil moisture preservation method for dry land apple trees

The invention discloses a rainwater collecting and soil moisture preservation method for dry land apple trees. The rainwater collecting and soil moisture preservation method for dry land apple trees comprises the steps of fertilizer application and soil preparation, ridging and film mulching or whole orchard film mulching, digging of rainwater collecting gutters, and straw covering in the rainwater collecting gutters and space between lines. The rainwater collecting and soil moisture preservation method for dry land apple trees is characterized in that soil processing is carried out before fertilizer application and soil preparation, 0.5 kilo of 40% of phoxim emulsifiable concentrate and 30 kilos of compound fine sand soil are mixed into compound poisonous soil to be applied per mu, and the compound fine sand soil is formed by mixing fine sand, horse dung, vermiculite and field soil according to the proportion of 2:2:1:3. The horse dung is dry horse dung with the water container not more ...

Novel carbostyril derivative and preparation and application thereof

The invention discloses a novel carbostyril derivative and a preparation and an application thereof. The carbostyril derivative has the structure shown as the formula (I-1) and the formula (I-2) and is prepared by the following steps: (1) leading polysubstituted acyl chloride shown as the formula (II) and an acrylic ester compound shown as the formula (III) to carry out reaction under the existence of an acid catching agent to obtain a product A; (2) leading the obtained product A and an amino acid hydrochloride compound shown as the formula (IV) to carry out reaction to obtain a product B; (3) carrying out the cyclization reaction of the obtained product B under the action of alkali to obtain a product C'; carrying out alkali hydrolysis on the rough product C' to obtain a product C; (4) leading the product C or the product C' to respectively react with the compound shown as a formula (V); fully reacting and then separating and purifying to obtain the corresponding carbostyril derivative ...

DOSAGE FORMS AND USE THEREOF

The present disclosure provides a stable solid pharmaceutical dosage form for oral administration. The dosage form includes a substrate that forms at least one compartment and a drug content loaded into the compartment. The dosage form is so designed that the active pharmaceutical ingredient of the drug content is released in a controlled manner. 129-. (canceled)30. An oral drug dosage form comprising:a) a column core having a top surface and a bottom surface, andb) a shell wrapping around the column core and leaving the top, bottom, or both surfaces exposed,wherein the shell has a slower dissolution rate than the substrate in the column core;wherein the column core comprises at least two vertical segments, each comprising a different drug embedded in a substrate, andwherein upon exposure to gastrointestinal fluid the drugs in the at least two vertical segments are simultaneously released through the exposed surface area.31. The oral drug dosage form of claim 30 , wherein the shell is water insoluble.32. The oral drug dosage form of claim 30 , wherein the substrate in each of the at least two vertical segments are the same.33. The oral drug dosage form of claim 30 , wherein the substrate in each of the at least two vertical segments are different from each other.34. The oral drug dosage form of claim 33 , wherein the drugs in the at least two different vertical segments are released at different rates.35. The oral drug dosage form of claim 30 , wherein the column core comprises at least three vertical segments.36. The oral drug dosage form of claim 35 , wherein the at least three vertical segments are pie-shaped.37. The oral drug dosage form of claim 30 , wherein only the top surface of the column core is exposed.38. The oral drug dosage form of claim 30 , wherein both the top surface and bottom surface of the column core are exposed.39. The oral drug dosage form of claim 30 , wherein the drugs in the at least two different vertical segments are released according ...

BACKLIGHT ASSEMBLY AND LIQUID CRYSTAL DISPLAY ASSEMBLY

The present invention provides a backlight assembly which includes a plastic frame, the plastic frame, a light guide plate, a light bar and an optical diaphragm group, a side surface of the plastic frame deviating from the reflective sheet is provided with a double-sided adhesive, at least one side frame of the plastic frame is provided with a groove which is disposed at a side surface of the plastic frame opposite to the double-sided adhesive, the double-sided adhesive includes a conductive heat dissipation layer and a double-sided adhesive layer, and a first metal sheet is disposed on a double-sided adhesive layer, located on the groove and contacts the optical diaphragm group and the conductive heat dissipation layer, respectively. The present invention further provides a liquid crystal display assembly. 1. A backlight assembly , comprising a plastic frame , a reflective sheet disposed at a side surface of the plastic frame , a light guide plate disposed in the plastic frame , a light bar disposed in the plastic frame and opposites to a side of the light guide plate and an optical diaphragm group disposed on a side surface of the light guide plate deviating from the reflective sheet , wherein a side surface of the plastic frame deviating from the reflective sheet is provided with a double-sided adhesive , at least one side frame of the plastic frame is provided with a groove which is disposed at a side surface of the plastic frame opposite to the double-sided adhesive and passes through an internal side and an external side of the frame of the plastic frame and a side surface of the frame of the plastic frame opposite to the double-sided adhesive; the double-sided adhesive comprises a conductive heat dissipation layer for conducting static and dissipating heat and a double-sided adhesive layer disposed on both side surfaces of the conductive heat dissipation layer , and a first metal sheet is disposed on a double-sided adhesive layer opposite to the plastic frame ...

Method for efficiently extracting microorganism total RNA (Ribonucleic Acid) from anaerobic granular sludge

The invention belongs to the technical field of environment molecular biology and relates to a method for efficiently extracting microorganism total RNA (Ribonucleic Acid) from anaerobic granular sludge. The method comprises the following steps: fetching activated sludge, centrifuging, discarding supernatant, then adding sterilized glass beads and a stock solution I into a centrifugal tube, putting the centrifugal tube in a vortex mixer for beating after a tube cover of the centrifugal tube is screwed tightly, centrifuging to discharge supernatant, and washing by a phosphate buffer solution; adding a stock solution II and incubating; adding a TRIzol, centrifuging to obtain supernatant after vortex oscillation, adding chloroform, carrying out vortex oscillation, putting in a room temperature, centrifuging to obtain supernatant, adding isopropanol, putting in a temperature of -20 DEG C, centrifuging to discharge supernatanth, adding 75% ethanol to wash precipitates, centrifuging to discharge ...

Application of LRRC4 gene promoter zone methylation detection to glioma diagnosis and detection system

The invention discloses an application of the LRRC4 gene promoter methylation detection to the glioma diagnosis and a detecting system thereof. The brain tissue specificity expressive gene LRRC4 is the glioma specificity methylate alienation gene, thereby indicating that the LRRC4 gene promoter methylation detection can be applied to the early period diagnosis of the glioma and the LRRC4 gene promoter methylation detecting system can be prepared by comprising a DNA bisulfite modification kit and an LRRC4 promoter methylation specificity PCR augmentation kit. The detecting system detects the specificity of the plasma LRRC4 promoter methylation state up to 92 percent, has high sensitivity, and can detect the plasma LRRC4 promoter methylation state of people quantificationally, thereby diagnosing the glioma of the patient rapidly without wound in the early time.

Copolymere von (meth)Acryloxy-Alkyl-Siloxysilane und Alkyl(meth)acrylate und deren Verwendung als druckempfindliche Klebstoffe

DOSAGE FORMS OF CONTROLLED RELEASE AT SPECIFIC GASTROINTESTINAL SITES

A dosage form of controlled release at specific gastrointestinal sites is provided. The dosage form includes a shell defining a first and a second compartment, a first active phamaecutical ingredient (API) loaded in the first compartment, and a second API loaded in the second compartment, wherein the first API and the second API can be the same or different. The shell includes a first material soluble in a first gastrointestinal site and a second material soluble in a second gastrointestinal site.

DOSAGE FORMS WITH DESIRED RELEASE PROFILES AND METHODS OF DESIGNING AND MAKING THEREOF

In some aspects, the present disclosure provides dosage forms, such as oral drug dosage forms, configured to provide a desired release profile, the dosage forms comprising a multi-layered structure comprising a plurality of layers of a first erodible material admixed with a compound (e. g., a drug) or a reagent, wherein the first erodible material is embedded in a second material not admixed with the compound (e. g., the drug) or the reagent. In other aspects, the present disclosure provides methods of designing, such as obtaining a thickness and/or surface area of a layer comprising an erodible material admixed with a compound (e. g., a drug) or a reagent, and/or amount of the compound (e. g., the drug) or the reagent admixed in the erodible material, and methods of making, such as three-dimensional printing, dosage forms configured to provide desired release profiles.

PRECISION PHARMACEUTICAL 3D PRINTING DEVICE

Provided herein are devices and systems for depositing a material or manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. Further provided are methods of using the devices and systems, as well as methods of manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. In certain embodiments, the device includes a material supply system (102) configured to melt and pressurize a material, a pressure sensor (214) configured to detect the pressure of the material within the device, and a control switch (216) comprising a sealing needle (218) operable in an open position and a closed position. The sealing needle (218) extends through a feed channel (208) containing the material and includes a tapered end (224), wherein the tapered end (224) of the sealing needle (218) engages a tapered inner surface of a nozzle (212) to inhibit flow of the material through the nozzle (212) when the sealing needle (218) is in the closed position ...

CONTROLLED RELEASE DOSAGE FORM

The present invention generally relates to a pharmaceutical dosage form and controlled release of biologically active agents, diagnostic agents, reagents, cosmetic agents, and agricultural/insecticide agents. In one embodiment, the dosage form has a substrate that forms a compartment, wherein the substrate includes at least a first piece and a second piece, wherein the first piece operably links to the second piece. The dosage form contains a drug content that is loaded into the compartment. The dosage form also has a releaser operably linked to the substrate which upon contact with water or body fluid is capable of separating the first and second piece to open the compartment and release the drug content.

COPOLYMERS OF (METH)ACRYLOXY-ALKYL-SILOXYSILANE AND ALKYL(METH)ACRYLATES AND THE USE THEREOF AS PRESSURE SENSITIVE ADHESIVES

COPOLYMERS OF (METH)ACRYLOXY-ALKYL-SILOXYSILANE AND ALKYL(METH)ACRYLATES AND THE USE THEREOF AS PRESSURE SENSITIVE ADHESIVES The present invention relates to copolymers of certain siloxy silanes and alkyl (meth)acrylate. Especially preferred is the embodiment wherein the silyloxy silane is 3-methacryloxypropyl-tris(trimethylsilyloxy)-silane and the alkyl (meth)acrylate is 2-ethylhexyl acrylate. It further relates to pressure sensitive adhesives, especially medical adhesives, suitable for use in transdermal therapeutic systems (TTS).

Adjustable walling crib

The utility model discloses an adjustable walling crib, including circle body, adjusting bolt and 3 at least embedded nut, embedded nut all buries underground in ring body, and embedded nut's opening setting is in the bottom of ring body, and every embedded nut all is provided with adjusting bolt supporting with it. The utility model discloses an adjustable walling crib, preparation installation is simple, and is practical, maneuverability is strong, has improved constructor's efficiency of construction, has ensured the precision and the construction quality of walling crib elevation to reduce the cost of engineering.

Rock mechanics three-axis testing high-pressure kettle

The invention discloses a rock mechanics three-axis testing high-pressure kettle, is designed for solving the problems of high machining cost, relatively large size and the like of equipment. A kettle body of the high-pressure kettle is arranged in a three-axis rack; a kettle cover with a central piston hole is connected and arranged at the top end of the kettle body, and a bearing base sealed by an annular sealing ring is connected to the bottom end of the kettle body; an axial loading piston sealed by an annular sealing ring is arranged in the kettle body, and a balance communication tube for communicating an upper space and a lower space of the piston is arranged on the sidewall of the kettle body; a piston rod on the upper part of the axial loading piston penetrates through the central piston hole in the kettle cover and sealed by the annular sealing ring, and the top end of the piston rod is connected with the top surface of the three-axis rack. The high-pressure kettle realizes the ...

Holographic natural code Chinese input system

Ship energy storage system based on water flow turbine power generation and ship

The ship energy storage system based on water flow turbine power generation comprises a turbine which is arranged at the bottom of a ship body and can make contact with water flow, the turbine comprises blades and a rotating shaft, the blades are driven by the water flow to rotate, and the blades rotate to drive the rotating shaft to rotate; the rotating shaft converts water kinetic energy into mechanical energy in the rotating process. And the gear box is connected with the output end of the rotating shaft and is used for increasing the rotating speed output by the rotating shaft and outputting the mechanical energy after the rotating speed is increased. And the generator is connected with an output shaft of the gear box, converts the mechanical energy transmitted by the gear box into electric energy and outputs alternating current. And the rectifying device is connected with the generator and is used for converting the alternating current output by the generator into direct current. And ...

Dosage forms and use thereof

It relates to a stable solid pharmaceutical dosage form for oral administration. The dosage form includes a substrate that forms at least one compartment and a drug content loaded into the compartment. The dosage form is so designed that the active pharmaceutical ingredient of the drug content is released in a controlled manner.

3D PRINTING DEVICE AND METHOD

A 3D printing device (100), comprising a melt extrusion module (102), a printing module (103), and a platform module (104). The melt extrusion module (102) comprises a processing chamber (121) consisting of a feed inlet (124) and a discharge outlet (125), as well as an extrusion means (122) and a heating means (123) disposed at the processing chamber; the melt extrusion module (102) is configured to receive an initial material from the feed inlet (124) of the processing chamber (121), and heat and extrude the initial material to convert the initial material into a molten body, which is extruded out of the discharge outlet (125) of the processing chamber (121). The printing module (103) is communicated with the discharge outlet (125) of the processing chamber (121) and is provided with a nozzle (131); the printing module (103) is configured to receive the molten body extruded from the discharge outlet (125) of the processing chamber (121) and guide the molten body to be extruded out of the ...

Low-power-consumption smoke sensing detection device and fire monitoring system based on same

The utility model provides a low-power-consumption smoke sensing detection device and a fire monitoring system based on the same, and the detection device comprises a battery, a smoke detection module, a control module, a switch module, a wireless communication module, and a camera. The battery is used for providing power; the smoke detection module is used for sending a fire alarm signal to the control module after sensing a fire alarm; the control module is used for sending a starting control signal to the switch module after receiving the fire alarm signal; the switch module is used for switching on the power supply connection between the battery and the camera after receiving the starting control signal; the camera is used for providing corresponding picture or/and video information; and the wireless communication module is used for transmitting the fire alarm signal and the picture or/and video information acquired by the control module to the outside and used for fire alarm and fire ...

Vehicle-mounted multimedia and portable telephone terminal interconnection system

The invention provides a system for interconnecting a vehicle-mounted multimedia and a portable telephone terminal. The system comprises a mobile phone end module, a vehicle machine end module, a vehicle-mounted controller module and a combination instrument module. The mobile phone end module comprises a mobile phone application program module and a mobile phone interconnection product SDK (Software Development Kit), and the mobile phone application program module is linked with the mobile phone interconnection product SDK. The vehicle machine end module comprises a vehicle machine application program module and a mobile phone interconnection vehicle end interconnection SDK (Software Development Kit), the vehicle machine application program module is linked with the mobile phone interconnection vehicle end interconnection SDK, and the mobile phone interconnection product SDK is linked with the mobile phone interconnection vehicle end interconnection SDK through a link protocol. The vehicle-mounted ...

Analysis method for measuring glucolactone related substances

The invention discloses an analysis method for measuring glucolactone related substances, which comprises the following steps: (1) preparing a test solution: taking a test, adding a diluent for dissolving, and quantitatively diluting to a set concentration to obtain the test solution; (2) setting chromatographic conditions: performing isocratic elution by adopting a chromatographic column taking triple bond bonded amido bonded silica gel as a filler, adopting a Hilic separation mode, taking an acidic aqueous solution as a mobile phase A and taking an organic solvent as a mobile phase B, and controlling the detection wavelength to be 205-220nm; and (3) determination and analysis: injecting 10-50 microliters of the test solution into a high performance liquid chromatograph, recording a chromatogram, and calculating the contents of gluconic acid-delta-lactone and related substances thereof, namely gluconic acid-gamma-lactone and gluconic acid according to an area normalization method. Quantitative ...

Salad maker

CHOLESTEROL-REGULATING COMPLEX OF SIRT1 AND LXR AND METHODS OF USE

A cholesterol-regulating complex of SIRT1 and LXR and methods of use are disclosed. SIRTl forms a complex with LXR bound to an LXR element. Methods o f forming the complex, identifying an agent that modulates formation of the complex, increasing the ratio of cholesterol bound to high density lipoprote in (HDL) to total cholesterol in the plasma of a mammal, promoting ABCA1 -me diated cholesterol efflux from a mammalian cell, treating a subject deemed t o have a level of SIRT1 activity that is below normal, assessing whether a c andidate substance modulates an LXR-dependent process, and assessing whether a candidate substance modulates an SIRTl -dependent effect of an LXR are di sclosed.

Preparation method of boron-containing structural steel

The invention discloses a preparation method of boron-containing structural steel. The boron-containing structural steel comprises the following chemical components by weight percent: 0.08-0.20% of C, 0.10-0.30% of Si, 0.80-1.50% of Mn, no more than 0.010% of P, no more than 0.010% of S, 0.0008-0.0030% of B and the balance of Fe and inevitable impurities. The preparation method comprises the following specific steps: heating to 1175-1225 DEG C for austenitization, and then performing multipass rolling, wherein the deformation temperature is between the austenitic recrystallization region and austenitic unrecrystallization region and the austenite-ferrite two-phase region; and then cooling to 600-660 DEG C at a cooling rate of 1-10 DEG C/s, and then performing air cooling. The boron-containing structural steel prepared by the method provided by the invention mainly contains ferrite, bainite and a small amount of pearlite. The structural steel has the advantages of uniform structure, fine ...

Liquid crystal display and backlight module thereof containing functional module and compensation light source

A liquid crystal display and a backlight module thereof are provided. The backlight module includes a backlight source and a light guide plate. The backlight source is disposed at a side surface of the light guide plate. The light guide plate has an accommodation section for accommodating a functional module. The backlight module includes a compensation light source that is disposed on the light guide plate. The accommodation section is located between the backlight source and the compensation light source. The backlight module includes a compensation light source, and the backlight source and the compensation light source are located at two opposite sides of the accommodation section. The compensation light source may compensate for the illumination light in the light guide plate blocked by the functional module, so as to solve the non-uniform display problem of blocking the illumination light from the backlight source by the functional module.

DOSAGE FORMS OF CONTROLLED RELEASE AT SPECIFIC GASTROINTESTINAL SITES

A dosage form of controlled release at specific gastrointestinal sites is provided. The dosage form includes a shell defining a first and a second compartment, a first active pharmaceutical ingredient (API) loaded in the first compartment, and a second API loaded in the second compartment, wherein the first API and the second API can be the same or different. The shell includes a first material soluble in a first gastrointestinal site and a second material soluble in a second gastrointestinal site.

Copolymere von (meth)Acryloxy-Alkyl-Siloxysilane und Alkyl(meth)acrylate und deren Verwendung als druckempfindliche Klebstoffe

Optimized cold spraying method for saving helium

The invention relates to an optimized cold spraying method for saving helium, and belongs to the technical field of the preparation of coatings. In the method, an integral spraying system is preheated by low-cost gas in the process of depositing a coating by cold spraying; when the pressure and temperature of low-cost gas at an inlet of a spray gun are close to those of preset working gas, the spraying is performed by switching to the working gas and filling powder granules; and the coating is deposited on the premise that the spraying process parameters of the powder granules are not changed, and a cold spraying process is optimized by the using amount of the working gas in the preheating process of a spraying saving system. In the optimized cold spraying method, a structure in the prior art is simplified, so the method is convenient to popularize and apply in large range.

Independent liquid tank insulation and protection system

The invention provides an independent liquid tank insulation and protection system. The system is arranged on the external wall of an independent liquid tank and comprises a thermal insulation layer, a protection layer, and a plurality of guiding gutter bodies. The thermal insulation layer is arranged on the external wall of the independent liquid tank, the protection layer is arranged on the external surface of the thermal insulation layer, and the guiding gutter bodies are arranged between the thermal insulation layer and the external wall of the independent liquid tank. Each guiding gutter body is provided with a guiding gutter that guides the fluid flowing, and the guiding gutters are corresponding to the butt-jointed seams in the external wall of the independent liquid tank. The guiding gutter bodies are connected to each other, and the guiding gutters are communicated with each other. The provided independent liquid chamber insulation and protection system can reduce the thermal transmission ...

Method for synthesizing 5,6,7,8-tetrahydroquinoline

The invention discloses a method for synthesizing 5,6,7,8-tetrahydroquinoline represented by a formula (I), which comprises the following steps: using quinoline represented by a formula (II) as a raw material and using PD as a catalyst, performing a catalytic hydrogenation reaction at a temperature of between 20 and 110 DEG C till the pressure of hydrogen is constant; emptying the hydrogen till the pressure is 2 atmospheres; stirring and raising temperature to between 140 and 300 DEG C to perform an isomerization reaction for 1 to 4 hours; and performing post treatment of reaction products after the reaction is finished to obtain the 5,6,7,8-tetrahydroquinoline. The method for preparing the PD catalyst comprises the following steps: adding a palladium-carbon catalyst with a palladium loading capacity of 5 weight percent into an aqueous of a hydrochloride, stirring the solution and heating the solution to between 10 and 50 DEG C, and adding a supercarbonate solution in the same amount into ...

Cholesterol-Regulating Complex of SIRT1 and LXR and Methods of Use

A cholesterol-regulating complex of SIRT1 and LXR and methods of use are disclosed. SIRT1 forms a complex with LXR bound to an LXR element. Methods of forming the complex, identifying an agent that modulates formation of the complex, increasing the ratio of cholesterol bound to high density lipoprotein (HDL) to total cholesterol in the plasma of a mammal, promoting ABCA1-mediated cholesterol efflux from a mammalian cell, treating a subject deemed to have a level of SIRT1 activity that is below normal, assessing whether a candidate substance modulates an LXR-dependent process, and assessing whether a candidate substance modulates an SIRT1-dependent effect of an LXR are disclosed.

PRECISION PHARMACEUTICAL 3D PRINTING DEVICE

Provided herein are devices and systems for depositing a material or manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. Further provided are methods of using the devices and systems, as well as methods of manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. In certain embodiments, the device includes a material supply system configured to melt an pressurized a material, a pressure sensor configured to detect a pressure of the material within the device, and a control switch comprising a sealing needle operable in an open position and closed position. The sealing needle extends through a feed channel containing the material and includes a taper end, wherein the tapered end of the sealing needle engages a tapered inner surface of a nozzle to inhibit flow of the material through the nozzle when the sealing needle is in the closed position. 129-. (canceled)30. A method of manufacturing a pharmaceutical dosage form by additive manufacturing , comprising:melting and pressurizing a pharmaceutically acceptable material;monitoring a pressure of the material within a nozzle or within a feed channel proximal to the nozzle, wherein the nozzle comprises a tapered inner surface adjacent to an extrusion port configured to dispense the material;flowing the material through the extrusion port of the nozzle;engaging a tapered end of a sealing needle with the tapered inner surface of the nozzle, thereby sealing the extrusion port and stopping flow of the melted material, wherein the tapered inner surface of the nozzle has a first taper angle and the tapered end of the sealing needle has a second taper angle, and wherein the second taper angle is the same or smaller than the first taper angle; andwithdrawing the tapered end of the sealing needle, thereby resuming flow of the material through the extrusion port.31. The method of claim 30 , wherein the pharmaceutically acceptable material comprises a drug.32. The ...

Grain-rein forced gradient composite material and preparation method thereof

The present invention discloses a granule reinforced gradient composite material and its preparation method, which is characterized by that in a molten liquid metal a high-hardness non-metal granulescan be mixed according to a certain ratio, and under the action of constant electromagnetic buoyancy force of external electromagnetic field the liquid metal can be formed into directional movement, and the reinforcing phase granules can be moved along the direction opposite from flowing direction of liquid metal, after they are cooled and set, the invented product can be obtained, in whith the reinforcing phase granules can be distributed in the emtal material in the gradient form, and its tissue and performance also have gradient change, and the loughness and plasticity of said composite material also can be improved.

Protective bracket for mechanical equipment storage battery

The utility model discloses a protective support for a storage battery of mechanical equipment, and belongs to the technical field of mechanical equipment. Including a support base, two sets of stablesliding rods are transversely arranged in an inner cavity of the supporting base. Two groups of adjusting slide blocks are symmetrically arranged on the outer walls of the two groups of stabilizing slide rods; according to the utility model, the control switch controls the rotation of the driving motor to drive the rotation of the adjusting screw; a series of mechanical transmission is performed;the adjusting sliding block can slide on the stable sliding rod; therefore, the supporting connecting rod can rotate when the adjusting sliding block slides; further, the supporting plate can ascendor descend when the supporting connecting rod rotates; the height of the storage battery installed at the top of the supporting plate is adjusted, meanwhile, through mutual cooperation of the positioning ...

SYSTEM AND METHOD FOR SINGLE-PHASE AND THREE-PHASE CURRENT DETERMINATION IN POWER CONVERTERS AND INVERTERS

A system and method for capturing current information for a power converter is disclosed. The current monitoring system includes a control system operably connected to a circuit having a plurality of semiconductor switches that are controllable to convert an input power to an output power having a desired voltage and current. The control system includes a PWM signal generator to generate switching signals that control switching of the switches, gate drivers to facilitate switching of the switches, and desaturation circuits to provide overcurrent protection to the switches. The control system further includes a processor that receives voltage data from the desaturation circuits regarding a measured voltage across each of the switches, determines a current through each of the switches based on the voltage across each respective switch, and calculates an input current to the circuit or an output current of the circuit based on the determined currents through the switches. 1. A current monitoring system for capturing current information for a power converter , the current monitoring system comprising:a circuit including a plurality of semiconductor switches being controllable to convert an input power from a source to an output power having a desired voltage and current; and a PWM signal generator configured to generate switching signals to control switching of the plurality of semiconductor switches;', 'a gate driver corresponding to each of the plurality of semiconductor switches and configured to receive the switching signals from the PWM signal generator and produce an amplified high-current drive signal for input to a respective semiconductor switch so as to facilitate efficient switching thereof;', 'a desaturation circuit connected to each gate driver to provide overcurrent protection to a respective semiconductor switch, the desaturation circuit configured to measure a voltage across its respective semiconductor switch; and', receive voltage data from the ...

Dosage forms with desired release profiles and methods of designing and making thereof

In some aspects, the present disclosure provides dosage forms, such as oral drug dosage forms, configured to provide a desired release profile, the dosage forms comprising a multi-layered structure comprising a plurality of layers of a first erodible material admixed with a compound (e. g., a drug) or a reagent, wherein the first erodible material is embedded in a second material not admixed with the compound (e. g., the drug) or the reagent. In other aspects, the present disclosure provides methods of designing, such as obtaining a thickness and/or surface area of a layer comprising an erodible material admixed with a compound (e. g., a drug) or a reagent, and/or amount of the compound (e. g., the drug) or the reagent admixed in the erodible material, and methods of making, such as three-dimensional printing, dosage forms configured to provide desired release profiles.

Green prevention and control method for purple root rot of codonopsis pilosula

The invention discloses a green prevention and control method for purple root rot of codonopsis pilosula, and belongs to the technical field of plant disease and insect pest prevention. The method comprises four steps of soil fumigation, soil improvement, seedling disinfection and production management. According to the invention, waste crop straws such as rice, corn, tobacco and the like are used for preparing the composite biomass charcoal with a soil improving effect, so that comprehensive utilization of the waste crop straws is realized, environmental pollution caused by straw burning is reduced, and environmental protection requirements and agricultural green sustainable development are met. In addition, soil fumigation is combined with soil improvement, so that soil-borne pathogenic bacteria in the soil can be effectively killed, the pH value of the soil is adjusted, the ecological environment of the soil is improved, the economic benefit is increased, and green and efficient production ...

DOSAGE FORMS WITH DESIRED RELEASE PROFILES AND METHODS OF DESIGNING AND MAKING THEREOF

In some aspects, the present disclosure provides dosage forms, such as oral drug dosage forms, configured to provide a desired release profile, the dosage forms comprising a multi-layered structure comprising a plurality of layers of a first erodible material admixed with a compound (e.g., a drug) or a reagent, wherein the first erodible material is embedded in a second material not admixed with the compound (e.g., the drug) or the reagent. In other aspects, the present disclosure provides methods of designing, such as obtaining a thickness and/or surface area of a layer comprising an erodible material admixed with a compound (e.g., a drug) or a reagent, and/or amount of the compound (e.g., the drug) or the reagent admixed in the erodible material, and methods of making, such as three-dimensional printing, dosage forms configured to provide desired release profiles.

Cholesterol-regulating complex of SIRT1 and LXR and methods of use

Layered quantitative gas filling device

Preparation method of organic titanium cross-linking agent for polyhydroxy alcohol fracturing fluid

Method for efficiently extracting total DNA (deoxyribonucleic acid) of anaerobic granular sludge microorganisms

The invention belongs to the technical field of environmental molecular biology, and particularly relates to a method for efficiently extracting total DNA (deoxyribonucleic acid) of anaerobic granular sludge microorganisms, which comprises the following steps: centrifuging thalli; washing solid substances with a DNA storage solution I, adding the DNA storage solution I and lysozyme to perform incubation, and adding a storage solution II, a storage solution III and a storage solution IV to perform incubation; adding a phenol, chloroform and isoamyl alcohol mixed solution, and gently and evenly mixing in a figure-eight manner; centrifuging, taking the supernatant, adding a chloroform and isoamyl alcohol mixed solution, and gently and evenly mixing in a figure-eight manner; centrifuging, taking the supernatant, adding isopropanol, gently and evenly mixing, and standing at -20 DEG C for 30 minutes; centrifuging at room temperature; washing once with 75% ethanol, and centrifuging at 12000r/min ...

Copolymers of (meth)acryloxy-alkyl-siloxysilane and alkyl(meth)acrylates and the use thereof as pressure sensitive adhesives

Water quality analysis device

The invention discloses a water quality analysis device, and relates to the technical field of water quality analysis, the water quality analysis device comprises a mounting rod and a floating plate, an electric wire is fixedly mounted in the mounting rod, an electrode is electrically mounted at the output end of the electric wire, the side wall of the electrode is in threaded connection with a filter screen cylinder, and the water quality analysis device further comprises a water inlet and a water outlet which are respectively arranged on the surface of the filter screen cylinder, the cleaning device is used for treating impurities in pores in the surface of the filter screen cylinder and comprises a guide strip fixedly mounted on the side wall of the filter screen cylinder, the guide strip is of an arc-shaped structure, a rotating ring is slidably mounted on the side wall of the guide strip, and a plurality of bristles are uniformly and fixedly mounted on the inner wall of the rotating ...

Precision pharmaceutical 3D printing device

Provided herein are devices and systems for depositing a material or manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. Further provided are methods of using the devices and systems, as well as methods of manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. In certain embodiments, the device includes a material supply system (102) configured to melt and pressurize a material, a pressure sensor (214) configured to detect the pressure of the material within the device, and a control switch (216) comprising a sealing needle (218) operable in an open position and a closed position. The sealing needle (218) extends through a feed channel (208) containing the material and includes a tapered end (224), wherein the tapered end (224) of the sealing needle (218) engages a tapered inner surface of a nozzle (212) to inhibit flow of the material through the nozzle (212) when the sealing needle (218) is in the closed position ...

Water rocket launching device

The invention discloses a water rocket launching device and relates to the technical field of manufacture of experiment teaching aids. The water rocket launching device comprises a launching plate, wherein the launching plate is hinged to a seat plate through a hinged shaft; the seat plate is provided with a limiting plate on which the launching plate rotates around the hinged shaft; an inflating nozzle sheathed with a conical sealing ring is formed in the launching plate; the launching plate is provided with an arc-shaped positioning plate on one side of the inflating nozzle, at least two movable pressure rods are mounted between the positioning plate and the inflating nozzle, and an ejector is arranged on the other side of the inflating nozzle and provided with an ejector plate hinged to the launching plate, an arc-shaped clamping groove for clamping the movable pressure rod is formed in the ejector plate, and a control brake handle is connected with the ejector plate through a steel ...

method for making ultrafine grained steel

The invention discloses a method for making ultrafine grained steel, comprising the steps of: heating carbon steel to a temperature of 1200-1240DEG C to carry out austenization, wherein the carbon steel contains 0.02-0.20% of carbon and 0.40-1.60% of manganese by mass fraction; controlling to roll by using an austenite recrystallization area and an austenite non-recrystallization area; performing another deformation near an Ar3 temperature by combining the deformation induced ferrite transformation technology so as to restrain the reverse transformation from the ferrite to the austenite after twice transformation, accumulate mass storage energy of the second transformation, increase the nucleation points of the ferrite, and promote the increase of the volume fraction of the ferrite; and finally cooling to a temperature of 600-650DEG C at a cooling speed of 1-10DEG C/micron for air cooling. The ferrite grain dimension of the prepared ultrafine grained ferrite steel is less than 3.0 microns ...

Arginine deiminase mutant from arthritis-type mycoplasma and application thereof

The invention discloses an arginine deiminase mutant from an arthritis-type mycoplasma, a gene, a polyethylene glycol modified substance and an application thereof. The arginine deiminase mutant is a dipolymer which is formed by two protein subunits, wherein amino sequences of the protein subunits are represented as SEQ ID No.2 in a sequence table. The arginine deiminase mutant is increased in expression quantity in escherichia coli, is increased in renaturation efficiency, is not changed in enzyme activity and is suitable for industrial production. The polyethylene glycol modified substance of the arginine deiminase mutant can be used for preparing anti-tumor drugs, such as anti-hepatoma drugs, anti-leukemia drugs and anti-melanoma drugs.

电磁连续铸造高速钢复合轧辊方法

A method for electromagnetic conticasting of composite high-speed steel roller includes such steps as preheating the ball-ground cast iron particles in protective atmosphere, putting them in conticasting mould, externally applying an adjustable MF magnetic field, pouring the molten high-speed steel in the conticasting mould while electromagnetic stirring, and quick cooling.

Health monitoring system and method based on wireless sensing

The invention discloses a health monitoring system and method based on wireless sensing, and relates to the field of medical health monitoring, the health monitoring system comprises a non-contact sensing device and a big data center background which are in signal connection with each other, and the non-contact sensing device comprises a behavior action recognition module, a target positioning recognition module and a filtering interference impurity removal module. The big data center background comprises a client and a server, and the client has a real-time health monitoring function, a health service function, a work and rest time statistics function, a home safety function, a map positioning function and a care consultation function; according to the system, the intelligence of the non-contact sensing device and the big data center is combined, mutual cooperation and cooperation of the non-contact sensing device and the big data center are achieved, efficient data collection is achieved ...

DOSAGE FORMS WITH DESIRED RELEASE PROFILES AND METHODS OF DESIGNING AND MAKING THEREOF

Dosage forms of controlled release at specific gastrointestinal sites

A dosage form of controlled release at specific gastrointestinal sites is provided. The dosage form includes a shell defining a first and a second compartment, a first active phamaecutical ingredient (API) loaded in the first compartment, and a second API loaded in the second compartment, wherein the first API and the second API can be the same or different. The shell includes a first material soluble in a first gastrointestinal site and a second material soluble in a second gastrointestinal site.

Novel carbostyril compound, preparation and application thereof

The invention discloses a novel carbostyril compound, preparation and application thereof. The structure of the carbostyril compound is shown as the formula (I-1) or the formula (I-2). The carbostyrilcompound is prepared through the following method: (1) reacting multi-substituted acyl chloride shown as the formula (II) with an acrylic ester compound shown as the formula (III) in the presence ofan acid-binding agent to obtain a product A; (2) reacting the obtained product A with an amino acid hydrochloride compound shown as the formula (IV) to obtain a product B; (3) carrying out a cyclization reaction on the obtained product B under the action of alkali and then treating an obtained product to obtain the compound shown as the formula (I-2); and post-treating the compound shown as the formula (I-2) through alkali hydrolysis and then separating and purifying the compound to obtain the compound shown as the formula (I-1). Groups with novel structural characteristics and physiological functions ...

Method for carrying out denitrifying phosphorus removal by controlling sectional addition of nitrite in real time

The invention discloses a method for carrying out the denitrifying phosphorus removal by controlling the sectional addition of nitrite in real time, belonging to the field of sewage treatment. The invention solves the problem that the nitrite with overhigh concentration can generate inhibition when taken as an electron acceptor to carry out the anoxic phosphorus uptake in the traditional SBR (Sequencing Batch Reactor) process. The method disclosed by the invention comprises the following steps of: picking sludge at an anaerobic end to carry out the sequencing batch experiment so as to determine the inhibition threshold, selecting the concentration as the addition concentration, fractionally adding the nitride as the electron acceptor to be subjected to the anoxic phosphorus uptake, adding the nitride when a pH value generates an inflection point from raising to reducing and regulating the pH value of a whole system; meanwhile, online monitoring ORP (Oxidation-Reduction Potential), and immediately ...

Database performance problem detection method oriented to I/O concurrency

The invention discloses an I/O concurrency-oriented database performance problem detection method, and aims to effectively detect the problem of performance discomfort between a database and hardware equipment. According to the technical scheme, the method comprises the following steps: constructing a performance discomfort detection system consisting of an I/O system call identification module, an I/O configuration item identification module, a test sample generation module and a discomfort detection module; the I/O system call identification module merges I/O related system calls and deletes repeated elements to obtain an I/O related system call set; the I/O configuration item identification module is used for screening out I/O related configuration items in the software to be tested by adopting a taint analysis method; the test sample generation module generates a test sample; and the unfit detection module executes the test sample, collects runtime information and judges whether an ...

Controlled release dosage form

The present invention generally relates to a pharmaceutical dosage form and controlled release of biologically active agents, diagnostic agents, reagents, cosmetic agents, and agricultural/insecticide agents. In one embodiment, the dosage form has a substrate that forms a compartment, wherein the substrate includes at least a first piece and a second piece, wherein the first piece operably links to the second piece. The dosage form contains a drug content that is loaded into the compartment. The dosage form also has a releaser operably linked to the substrate which upon contact with water or body fluid is capable of separating the first and second piece to open the compartment and release the drug content.

Dosage forms and use thereof

It relates to a stable solid pharmaceutical dosage form for oral administration. The dosage form includes a substrate that forms at least one compartment and a drug content loaded into the compartment. The dosage form is so designed that the active pharmaceutical ingredient of the drug content is released in a controlled manner.

Heat treatment method for improving the bearing capacity of thin wall steel pieces

The heat treatment method of raising bearing capacity of thin-wall steel part includes first heating the cold deformation formed workpiece to the temperature range of Fe-N system austenite arean and nitriding to form nitrogen containing austenite layer, and then cooling the workpiece fast to below 300 deg.c to inhibit the euterctoid conversion of the nitrogen containing austenite and to decompose the austenite layer into dispersed two-phase structure or to convert into martensite. The said method makes the nitrogen containing austenite layer reinforced and the raises the overall structural strength of the thin-wall steel part greatly. The said method of raising the bearing capacity features no special requirement in the chemical components of the material and is suitable for ultralow carbon steel, low carbon steel, low alloy steel, etc.

Application finish paint front shroud supports frock

The utility model discloses an application finish paint front shroud supports frock, including locking Assembly and bracing piece, locking Assembly includes base and locking bolt, is equipped with articulated seat and the bolt hole that the confession locking bolt passed on the base, is equipped with spacing post in the bottom of base, the lower extreme of bracing piece hinges on articulated seat, and the upper end of bracing piece is equipped with the front shroud support and colludes, and this front shroud supports the lower extreme that colludes and is provided with the support step. The utility model provides a safety problem that automobile coating finish paint in -process frock removed or the fracture arouses to reach frock uniformity difference and influence the problem of processing quality.

System and method for additively manufacturing boiler tubes

A method of manufacturing a tube is provided. The method includes: selecting a core pipe having a thickness that is initially less than a desired thickness of the tube; and building-up an outer layer over an exterior surface of the core pipe via additive manufacturing so as to increase the thickness of the core pipe such that the thickness of the core pipe is equal to the desired thickness of the tube.

Compartmented pharmaceutical dosage forms

The present disclosure provides a stable solid pharmaceutical dosage form for oral administration. The dosage form includes a substrate that forms at least one compartment and a drug content loaded into the compartment. The dosage form is so designed that the active pharmaceutical ingredient of the drug content is released in a controlled manner.

Expression vector and anti-tumor reagent of long-chain non-coded RNALOC401317, and applications of expression vector and anti-tumor reagent

The invention discloses an expression vector and an anti-tumor reagent of long-chain non-coded RNALOC401317, and applications of the expression vector and the anti-tumor reagent, namely the applications in preparation of a preparation for inhibiting growth and proliferation of tumor cells. According to a sequence of the lncRNA, a eukaryotic expression vector for overexpression of LOC401317 is designed and synthesized, and loaded on polylysine modified silicon nano-particles to prepare nano-spheres, so that the LOC401317 is successfully expressed in a nasopharynx cancer cell line and the growth of the nasopharynx cancer cells is inhibited. The polylysine modified silicon nano-particles mentioned in the invention can protect the LOC401317 vector from degradation of nuclease and prolong the action time, and thus a higher transfection efficiency is realized and further development and application are facilitated.

Megawatt level composite material wind electricity blade vacuum guiding and forming technique

The invention discloses a vacuum infusion forming process for a megawatt grade composite material wind turbine blade. The process comprises a step of spreading and cladding reinforced material layers in an upper mold cavity and a lower mold cavity of a mould of the blade respectively and a step of solidification, demoulding and product forming, and is characterized by comprises the following steps between the two steps: 1)distributing injection systems on the surfaces of the reinforced material layers; 2) distributing vacuum systems on the outer surface of the injection systems spread and covered with flow channels in the step 1); 3) checking the airtight performance of an vacuumizing opening; 4) mould filling ( filling rubber liquid); and 5), solidification, demoulding and product forming. The vacuum infusion process can complete mould filling in 1.5 hours, improves the forming efficiency of large blades, saves special equipment and achieves low production costs. Products formed by the ...

Artificial magnetic conductor reflection chamber for broadband plane helix antenna

The invention provides an artificial magnetic conductor reflection chamber, comprising an artificial magnetic conductor array unit and a medium substrate. The artificial magnetic conductor array unit is arranged on the medium substrate. The artificial magnetic conductor array unit is composed of a microstrip sheet and a microstrip sheet central through hole. The size of the microstrip sheet and the central through hole is linked to the wavelength of the work frequency of the helix antenna and the work bandwidth. The artificial magnetic conductor reflection chamber is used for a broadband helix antenna reflecting plate, which can reduce the antenna profile and increase gain. The size of the artificial magnetic conductor array unit changes with the frequency in a gradient manner from inside to outside, and thereby the broadband coupling of the artificial magnetic conductor can be realized.

IO size-oriented database performance problem detection method

The invention discloses an IO size-oriented database performance problem detection method, and aims to provide a method for effectively detecting database performance problems caused by IO size inadaptation. According to the technical scheme, the method comprises the steps that a database performance problem detection system composed of a configuration item extraction module, a test sample generation module, an IO related test sample extraction module, a runtime data collection module and an unfit problem detection module is constructed; the configuration item extraction module obtains a configuration item parameter set according to the database configuration item list; a test sample generation module generates a test sample set according to the configuration item parameter set; the IO related test sample extraction module identifies IO related configuration items and generates a new test sample set; during operation, the data acquisition module executes the test sample and obtains a test ...

Combined type dust-removing testing device and testing method

The invention belongs to the field of performance tests of smoke and dust generation, monitoring and different dust removing technologies, and particularly relates to a combined type dust-removing testing device and a testing method. The combined type dust-removing testing device comprises a dust generating system, a dust-removing testing box body and a dust removing system, wherein the dust generating system is connected with the dust-removing testing box body; the dust-removing testing box body is connected with the dust removing system. The combination of dust removers in the dust removing system can be flexibly adjusted according to the test requirements; tests on each of the dust removers can be separately carried out or can be carried out after the dust covers are combined, so that the comprehensive dust removal effect of the plurality of dust removers can be achieved, particularly the grade dust-removing efficiency on particles with different grain diameters can be measured and calculated ...

Paper pulp dehydration device and method adopting centrifugal separation technology

The invention relates to the field of papermaking and pulping, in particular to a paper pulp dewatering device and method adopting a centrifugal separation technology. According to the paper pulp dewatering device and method adopting the centrifugal separation technology, centrifugal force borne by paper pulp can be more uniform through stirring, the paper pulp can be dewatered more sufficiently, the rotating barrel can stop rotating more quickly, and the paper pulp dewatering efficiency is more effectively improved. The invention discloses a paper pulp dewatering device and method adopting a centrifugal separation technology. The paper pulp dewatering device comprises a base, a box body, a driving motor and the like, the top of the base is fixedly connected with a box body, and the top of the base is fixedly connected with a driving motor. A worker starts a driving motor, water in paper pulp can be discharged out of the device through a water discharging pipe on the lower portion of the ...

Method for controlling gooey with 100% waste newsprint paper deinked pulp esterase

Foldable waist-wearing rope-driven outer limb robot with telescopic function

The invention discloses a foldable waist-wearing rope-driven outer limb robot with a telescopic function, and relates to the technical field of outer limb robots. Through the arrangement of the mechanical arm with the functions of stretching, folding, rotating and bending, the range of the applicable working space of the mechanical arm is expanded, and then operation of different types of work is completed. The outer limb robot comprises a waist supporting piece, a rigid large arm, a rigid small arm, a telescopic small arm, an end effector, a rigid small arm rotation driving mechanism, a telescopic small arm folding driving mechanism, a telescopic small arm bending driving mechanism and an end effector driving mechanism. The waist supporting piece, the rigid large arm, the rigid small arm, the telescopic small arm and the end effector are connected in sequence; the rigid small arm rotation driving mechanism can drive the rigid small arm to rotate; the telescopic small arm folding driving ...

Gene detection reagent and kit for corneal dystrophy

The invention provides a gene detection kit for corneal dystrophy, the gene detection kit comprises a blood sample pretreatment reagent and an amplification reagent, the blood sample pretreatment reagent comprises 1-50 mM of Tris, 1-20 mM of guanidine isosulfate, 20-80 mM of lauryl alcohol, 300-500 mM of erythritol, 5000-8000 U/mL of neutral protease and the balance of water, and the pH value is 6.5-7.5; the amplification reagent comprises an amplification primer and a probe. When the kit provided by the invention is used for detecting the corneal dystrophy from a whole blood sample, the operation is simple and convenient, the consumed time is short, additional nucleic acid extraction operation is not needed, the detection accuracy of the kit is high, the kit can be used for etiological diagnosis and gene screening of the corneal dystrophy, and the clinical application prospect is relatively wide.

Biological composition as well as preparation method and application thereof

The invention relates to a biological composition as well as a preparation method and application thereof. The biological composition comprises at least one positive cell line as a positive standard, at least one negative cell line as a negative standard, at least one positive genomic vector as a positive reference, and at least one negative genomic vector as a negative reference. The biological composition can be used as a standard substance capable of realizing different gradient positive signals, and can be used for evaluating the accuracy of a methylation detection method.

Health data collection and recognition method used for health equipment

Disclosed is a health data collection and recognition method used for health equipment. Interface information of the health equipment is acquired through direct photographing, so that low cost and simplicity in operation are realized, complexity when old people input data manually is lowered; habits of the old people are met, and difficulty when the old people use the health equipment is lowered; requirements, of the old people, on simplicity in operation, convenience and easiness in understanding are met. On the basis of codes of practice peculiar to medical information industry, professional data can be interpreted more comprehensively and accurately through preset information, and richness of information is improved. By implementing mode recognition technology based on a preset template on specific targets, data recognition efficiency and data accuracy are improved greatly.

Oral drug dosage forms having a desired PK profile and methods of designing and producing thereof

The present disclosure, in some aspects, is directed to methods of designing an oral drug dosage form formulated and configured to have a desired pharmacokinetic profile. In other aspects, the present disclosure is directed to oral drug dosage forms having a desired pharmacokinetic profile, and methods of making, such as three-dimensional printing, such oral drug dosage forms.

Multi-chamber tire manufacturing mold

A multi-chamber tire manufacturing mold, comprising an upper holding plate and a lower holding plate having an interval between the upper holding plate and the lower holding plate; a tire periphery forming slider, a tire inner chamber forming slider, an upper mold block, a lower mold block, and a central mold post are arranged in the interval; the upper holding plate is connected to the plurality of upper mold blocks, and the lower holding plate is connected to a plurality of lower mold blocks, forming an enclosed chamber; the tire inner chamber forming slider arranged in the enclosed chamber, forming a flexible portion chamber and a partitioned chamber, such that isolating chambers are formed in the flexible portion; the openings of which together with the tire periphery forming slider form an enclosed chamber via process sealing members and fill the forming outer body.

Anti-radiation lead garment for operating room

The invention discloses an anti-radiation lead garment for an operating room. The anti-radiation lead garment comprises a lead garment body and a neck protection device. The neck protection device is formed by an air inflation neck protection piece and a protection surface layer arranged on the air inflation neck protection piece. The upper side edge of the protection surface layer is connected onto the outer surface of the air inflation neck protection piece in the circumferential direction of the air inflation neck protection piece, the left side of the protection surface layer and the right side of the protection surface layer are connected through a hook and loop fastener, the lower side edge of the protection surface layer is connected to the position of the edge of a neckline at the upper end of the lead garment body, and anti-radiation surface layers are arranged on the outer surface of the air inflation neck protection piece and the outer surface of the protection surface layer.

Method for applying minor pinellia ternate decoction dregs to cultivating functional crops

The invention belongs to the technical field of application of decoction dregs, and relates to a method for applying minor pinellia ternate decoction dregs to cultivating functional crops. Effects of relieving and inhibiting emesis can be realized by the cultivated crops such as grain, fruits and vegetables. The method particularly includes adding fresh water into Chinese herbal medicines or the decoction dregs of minor pinellia ternate decoction formulas to soak the Chinese herbal medicines or the decoction dregs, heating and decocting the Chinese herbal medicines or the decoction dregs, filtering the Chinese herbal medicines or the decoction dregs, uniformly mixing decocted filter liquor obtained in two procedures with each other for standby application, collecting the decoction dregs and then manufacturing decoction dreg cakes for standby application; diluting the uniformly mixed filter liquor, then soaking crop seeds in the filter liquor, sowing the seeds, irrigating and managing the ...

Aluminum-particle-based method for preparing coating by cold spray deposition

The invention discloses an aluminum-particle-based method for preparing a coating by cold spray deposition in the technical field of metal material coatings. Helium is used as a working gas and a carrier gas, and high-purity aluminum powder is sprayed onto a matrix subjected to iron silicate particle blasting treatment by using a spray gun to realize coating preparation. Various defects in the prior art, particularly in the thermal spraying aluminum coating preparation process are overcome, risks of small-size particles in storage and cold spray processes are overcome, and the cost of aluminum powder particle deposition is effectively reduced.

Method for synthesizing 3-(N,N-2-substituted amino)-2-substituted acrylic esters

The invention discloses a method for synthesizing 3-(N,N-2-substituted amino)-2-substituted acrylic esters, which comprises the following step of: in an organic solvent 1, performing amine substitution and elimination reaction on 2-substituent formyl acetate alkali metal salts shown in a formula (III) and amine complexes shown in a formula (II) to obtain the 3-(N,N-2-substituted amino)-2-substituted acrylic esters shown in a formula (I). The method has the advantages that: the reaction is simple and the method is convenient to operate; and in the method, N,N-2-substituted amino and CO2, or a liquid complex prepared from the N,N-2-substituted amino and the CO2 is taken as a raw material, byproducts influencing the environment are not generated in the whole process, and the method is a green synthesis method.

System and method for capacitor fault energy interruption in adjustable speed drives

An adjustable speed drive (ASD) circuit includes a rectifier bridge to convert an AC power input to a DC power, a DC link coupled to the rectifier bridge to receive the DC power, a DC link capacitor bank comprising at least first and second capacitors connected to the DC link, each capacitor having a capacitor voltage thereacross, and a protection circuit including a detection circuit configured to detect a short circuit on one or more of the first and second capacitors of the DC link capacitor bank and generate an action signal upon detection of a short circuit on one or more of the first and second capacitors of the DC link capacitor bank. The ASD circuit also includes an action circuit in operable communication with the detection circuit and configured to cause a short circuit across the DC link upon receiving the action signal from the detection circuit.

Stroller

The invention discloses a stroller which comprises a front wheel support, a rear wheel support, a seat frame, a stroller frame, a main sliding rod, a sliding rod, a traction supporting rod and a seat supporting rod. The front wheel support is provided with a front wheel assembly, the rear wheel support is provided with a rear wheel assembly. The front end of the seat frame is sleeved with a main rotating shaft. The stroller frame is connected with the seat frame. One end of the main sliding rod is connected with the rear wheel support, the main rotating shaft is sleeved with the other end of the main sliding rod, and a first sliding block and a second sliding block are arranged on the main sliding rod. One end of the sliding rod is connected with the front wheel support, and the other end of the sliding rod is connected with the first sliding block in a rotating mode. One end of the traction supporting rod is connected with the side wall of the sliding rod in a rotating mode, and the other ...

Arc vertebral plate drag hook

The utility model discloses an arc vertebral plate drag hook releases and the design when twisting fixed centrum with set screw under the circumstances of soft tissue around the safeguard during the operation of traffic stud stick behind the backbone. Including antiskid hook pull rod (1), handle (2) and semi -ring slot type arc protective shaft (3), antiskid hook pull rod links to each other with the one end of handle, and the other end and the semi -ring slot type arc protective shaft of handle are connected, and semi -ring slot type arc protective shaft's front end is arc drag hook head (4). The utility model discloses can convenient and fast ground lead out the soft tissue, reach reduce operation injury, shorten operation time, increase the operation success rate, the purpose of the operation of being convenient for. Whole design is characterized in sturdy and durable, easy and simple to handle, reduce operation injury, low cost etc.

Gravity-assisted steam flooding exploitation method for heavy laver common heavy oil reservoir

Method for carrying out denitrifying phosphorus removal by controlling sectional addition of nitrite in real time

The invention discloses a method for carrying out the denitrifying phosphorus removal by controlling the sectional addition of nitrite in real time, belonging to the field of sewage treatment. The invention solves the problem that the nitrite with overhigh concentration can generate inhibition when taken as an electron acceptor to carry out the anoxic phosphorus uptake in the traditional SBR (Sequencing Batch Reactor) process. The method disclosed by the invention comprises the following steps of: picking sludge at an anaerobic end to carry out the sequencing batch experiment so as to determine the inhibition threshold, selecting the concentration as the addition concentration, fractionally adding the nitride as the electron acceptor to be subjected to the anoxic phosphorus uptake, addingthe nitride when a pH value generates an inflection point from raising to reducing and regulating the pH value of a whole system; meanwhile, online monitoring ORP (Oxidation-Reduction Potential), andimmediately ...

DOSAGE FORMS WITH DESIRED RELEASE PROFILES AND METHODS OF DESIGNING AND MAKING THEREOF

In some aspects, the present disclosure provides dosage forms, such as oral drug dosage forms, configured to provide a desired release profile, the dosage forms comprising a multi-layered structure comprising a plurality of layers of a first erodible material admixed with a compound (e. g., a drug) or a reagent, wherein the first erodible material is embedded in a second material not admixed with the compound (e. g., the drug) or the reagent. In other aspects, the present disclosure provides methods of designing, such as obtaining a thickness and/or surface area of a layer comprising an erodible material admixed with a compound (e. g., a drug) or areagent, and/or amount of the compound (e. g., the drug) or the reagent admixed in the erodible material, and methods of making, such as three-dimensional printing, dosage forms configured to provide desired release profiles.

A magazine for flow cytometry analysis

The utility model discloses a magazine for flow cytometry analysis, including box body and lid, the inboard of box body is equipped with the filling layer, and the box body about the both ends upper surface be equipped with the buckle, the inner chamber middle part of box body is equipped with the light screen, the spring shock absorber device is installed to the lower extreme of light screen, the upper end of light screen is equipped with sample groove and antibody groove, and sample groove and antibody trench in the inner chamber of box body, be equipped with the baffle between sample groove and the antibody groove, the outside upper portion of lid is equipped with the slot, be equipped with the picture peg in the inner chamber of slot, the both ends inboard of lid is equipped with the cardboard. This magazine is through being equipped with the slot and having shading function picture peg for the user can according to actual need the control magazine is inside advances the light quantity ...

SYSTEM FOR OPTIMIZING SWITCHING DEAD-TIME AND METHOD OF MAKING SAME

A system for optimizing switching dead-time includes a power converter that includes a half-bridge circuit comprising a first switch coupled in series with a second switch, first and second state detection circuits respectively coupled to the first and second switches and configured to respectively detect an activation state of the first and second switches. First and second switch control circuits coupled respectively to the first and second switches are configured to respectively toggle the first and second switches between an activate state and a deactivated state. The first switch control circuit includes a first input configured to receive an activation signal from the second state detection circuit indicative of the activation state of the second switch, and the second switch control circuit includes a first input configured to receive an activation signal from the first state detection circuit indicative of the activation state of the first switch. 1. A power converter comprising:a half-bridge circuit comprising a first switch coupled in series with a second switch;a first state detection circuit coupled to the first switch and configured to detect an activation state of the first switch;a second state detection circuit coupled to the second switch and configured to detect an activation state of the second switch;a first switch control circuit coupled to the first switch and configured to toggle the first switch between an activate state and a deactivated state, the first switch control circuit comprising a first input configured to receive an activation signal from the second state detection circuit indicative of the activation state of the second switch;a second switch control circuit coupled to the second switch and configured to toggle the second switch between an active state and a deactivated state, the second switch control circuit comprising a first input configured to receive an activation signal from the first state detection circuit indicative of ...

Core-shell structure supported tungsten composite catalyst and preparation method and use thereof

The present invention discloses a core-shell structure supported tungsten composite catalyst and a preparation method and use thereof. Most of the existing synthesis methods of the main ring of quinolone drugs have the defects of many synthesis steps, cumbersome operation, large amount of three wastes, higher costs and the like. The present invention prepares a magnetic separable core-shell supported tungsten composite catalyst, WO3/SiO2/Fe3O4, by preparing Fe3O4 colloid and SiO2/Fe3O4 composite nano-particles. This magnetic separable core-shell supported tungsten composite catalyst, WO3/SiO2/Fe3O4, is used to catalyze and synthesize quinolone compounds. The present invention provides an efficient preparation method of quinolone compounds using a catalyst which can be recovered by magnetic separation and recycled. The catalyst prepared by the present invention can be reused in the preparation of quinolone compounds and still retains the original activity without deactivation, which not only greatly improves the production efficiency, but also reduces the environmental pollution.

SYSTEMS FOR STABILIZING AND DELIVERING ACTIVE AGENTS

A delivery system for active agents, and methods of making and using the systems, are provided. The delivery systems have (i) a ligand that is selective for an endogeneous plasma protein in the serum of a subject; and, (ii) a linker configured for operatively attaching the ligand covalently to an active agent to increase the half-life of the active agent in the serum. 121-. (canceled)25. A method of increasing the in vivo half-life of an active agent claim 23 , the method comprising covalently attaching the delivery system of to an active agent claim 23 , the active agent comprising a structure selected from the group consisting of a peptide claim 23 , an oligopeptide claim 23 , a polypeptide claim 23 , a protein claim 23 , an antibody claim 23 , an oligonucleotide claim 23 , a polynucleotide claim 23 , a virus-like particle claim 23 , a small molecule claim 23 , an oligosaccharide claim 23 , an imaging agent claim 23 , and combinations thereof.26. A method of increasing the in vivo half-life of an active agent claim 24 , the method comprising covalently attaching the delivery system of to an active agent claim 24 , the active agent comprising a structure selected from the group consisting of a peptide claim 24 , an oligopeptide claim 24 , a polypeptide claim 24 , a protein claim 24 , an antibody claim 24 , an oligonucleotide claim 24 , a polynucleotide claim 24 , a virus-like particle claim 24 , a small molecule claim 24 , an oligosaccharide claim 24 , an imaging agent claim 24 , and combinations thereof.27. A method of increasing the in vivo half-life of an active agent in blood serum claim 22 , the method comprising covalently attaching the delivery system of to an active agent claim 22 , the active agent comprising a structure selected from the group consisting of a peptide claim 22 , an oligopeptide claim 22 , a polypeptide claim 22 , a protein claim 22 , an antibody claim 22 , an oligonucleotide claim 22 , a polynucleotide claim 22 , a virus-like particle ...

CONJUGATION OF PHARMACEUTICALLY ACTIVE AGENTS WITH TRANSTHYRETIN LIGANDS THROUGH ADJUSTABLE LINKERS TO INCREASE SERUM HALF-LIFE

A delivery system for active agents, and methods of making and using the systems, are provided. The delivery systems have (i) a ligand that is selective for an endogeneous plasma protein in the serum of a subject; and, (ii) a linker configured for operatively attaching the ligand covalently to an active agent to increase the half-life of the active agent in the serum. 1. A delivery system for an active agent , comprising:{'sup': '−6', 'a ligand with (i) a high selectivity for a plasma protein endogeneous to the subject, the molecular weight of the plasma protein ranging from about 30 kDa to about 80 kDa; (ii) a high binding affinity, Kd, of at least 10M for the plasma protein; and, (iii) a molecular weight ranging from about 200 Da to about 2000 Da;'}and,a linker that ranges in length from about 10 angstroms to about 50 angstroms, or from 8 atoms to 50 atoms;wherein, the active agent has a structure selected from the group consisting of a peptide, an oligopeptide, a polypeptide, a protein, an antibody, an oligonucleotide, a polynucleotide, a virus-like particle, a small molecule, an imaging agent, and combinations thereof.2. (canceled)3. (canceled)4. The delivery system of claim 1 , wherein the plasma protein is TTR.8. (canceled)10. The delivery system of claim 9 , wherein:R1 is methyl and R3 is methyl;Xa is O, and,Y is fluoro or carboxyl.12. The delivery system of claim 11 , wherein Ris selected from bromo claim 11 , chloro and fluoro.20. A method of increasing the in vivo half-life of an active agent claim 5 , the method comprising covalently attaching the delivery system of to an active agent claim 5 , the active agent comprising a structure selected from the group consisting of a peptide claim 5 , an oligopeptide claim 5 , a polypeptide claim 5 , a protein claim 5 , an antibody claim 5 , an oligonucleotide claim 5 , a polynucleotide claim 5 , a virus-like particle claim 5 , a small molecule claim 5 , an oligosaccharide claim 5 , an imaging agent claim 5 , and ...

SYSTEM AND METHOD FOR CAPACITOR FAULT ENERGY INTERRUPTION IN ADJUSTABLE SPEED DRIVES

An adjustable speed drive (ASD) circuit includes a rectifier bridge to convert an AC power input to a DC power, a DC link coupled to the rectifier bridge to receive the DC power, a DC link capacitor bank comprising at least first and second capacitors connected to the DC link, each capacitor having a capacitor voltage thereacross, and a protection circuit including a detection circuit configured to detect a short circuit on one or more of the first and second capacitors of the DC link capacitor bank and generate an action signal upon detection of a short circuit on one or more of the first and second capacitors of the DC link capacitor bank. The ASD circuit also includes an action circuit in operable communication with the detection circuit and configured to cause a short circuit across the DC link upon receiving the action signal from the detection circuit. 1. An adjustable speed drive (ASD) circuit comprising:an input connectable to an AC source;a rectifier bridge connected to the input to convert an AC power input to a DC power;a DC link coupled to the rectifier bridge to receive the DC power therefrom;a DC link capacitor bank comprising at least first and second capacitors connected to the DC link, each capacitor of the DC link capacitor bank having a capacitor voltage thereacross; and [ detect a short circuit on one or more of the first and second capacitors of the DC link capacitor bank; and', 'generate an action signal upon detection of a short circuit on one or more of the first and second capacitors of the DC link capacitor bank; and, 'a detection circuit configured to, 'an action circuit in operable communication with the detection circuit and configured to cause a short circuit across the DC link upon receiving the action signal from the detection circuit., 'a protection circuit comprising2. The ASD circuit of wherein the detection circuit comprises:a first opto-coupler operably connected to the first capacitor; anda second opto-coupler operably connected ...

ORAL DRUG DOSAGE FORMS COMPROMISING A FIXED-DOSE OF AN ADHD NON-STIMULANT AND AN ADHD STIMULANT

The present disclosure provides oral drug dosage forms comprising: (a) an erodible non-stimulant material admixed with an ADHD non-stimulant; and (b) an erodible stimulant material admixed with an ADHD stimulant, wherein the erodible non-stimulant material admixed with the ADHD non-stimulant is embedded in a substrate material, and wherein upon exposure to gastrointestinal fluid the ADHD non-stimulant is released according to a desired non-stimulant release profile and the ADHD stimulant is released according to a desired stimulant release profile. In some embodiment, the ADHD non-stimulant is released according to a sustained release profile. In some embodiments, the ADHD stimulant is released according to an immediate release profile. The oral drug dosage forms of the present disclosure are useful for the treatment of attention deficit hyperactivity disorder (ADHD). Also provided herein are methods of designing and manufacturing the oral drug dosage forms described herein. 1. An oral drug dosage form comprising:(a) an erodible non-stimulant material admixed with an ADHD non-stimulant; and wherein the erodible non-stimulant material admixed with the ADHD non-stimulant is embedded in a substrate material, and', 'wherein upon exposure to gastrointestinal fluid the ADHD non-stimulant is released according to a sustained release profile and the ADHD stimulant is released according to an immediate release profile., '(b) an erodible stimulant material admixed with an ADHD stimulant,'}2. The oral drug dosage form of claim 1 , wherein the oral drug dosage form comprises a multi-layered structure comprising a plurality of layers of the erodible non-stimulant material admixed with the ADHD non-stimulant.34-. (canceled)5. The oral drug dosage form of claim 2 , wherein each layer of the erodible non-stimulant material admixed with the ADHD non-stimulant of the multi-layered structure has a pre-determined surface area claim 2 , thickness claim 2 , and ADHD non-stimulant mass ...

ENHANCED ACTIVE AGENTS

The teachings provide active agents that are conjugated with delivery systems that increase the half-life, and reduce the immunogenicity, of the active agents. Methods of making and using the systems are also provided. The delivery systems have (i) a ligand that is selective for an endogeneous plasma protein in the serum of a subject; and, (ii) a linker configured for operatively attaching the ligand covalently to an active agent to increase the half-life of the active agent in the serum. 4. The enhanced active agent of claim 1 , the drug having a structure selected from the group consisting of a peptide claim 1 , an oligopeptide claim 1 , a polypeptide claim 1 , a protein claim 1 , an antibody claim 1 , an oligonucleotide claim 1 , a polynucleotide claim 1 , a virus-like particle claim 1 , a small molecule claim 1 , an oligosaccharide claim 1 , an imaging agent claim 1 , and combinations thereof.5. The enhanced active agent of claim 1 , the drug having an increased half-life in blood serum when conjugated to the delivery system.6. The enhanced active agent of claim 1 , the drug having a reduced immunogenicity in blood serum when conjugated to the delivery system.7. The enhanced active agent of claim 2 , the drug having an increased half-life in blood serum when conjugated to the delivery system.8. The enhanced active agent of claim 2 , the drug having a reduced immunogenicity in blood serum when conjugated to the delivery system.9. The enhanced active agent of claim 3 , the drug having an increased half-life in blood serum when conjugated to the delivery system.10. The enhanced active agent of claim 3 , the drug having a reduced immunogenicity in blood serum when conjugated to the delivery system.11. The enhanced active agent of claim 4 , the drug having an increased half-life in blood serum when conjugated to the delivery system.12. The enhanced active agent of claim 4 , the drug having a reduced immunogenicity in blood serum when conjugated to the delivery system ...

Identity authentication by using human biological characteristic

A human biological characteristic file corresponding to a particular identity is received and used as a base file. A characteristic code to be authenticated is obtained according to a human biological characteristic of a person who requests identity authentication when an identity authentication request corresponding to the particular identity is received. A base characteristic code is collected from a base file. A collecting algorithm applied for collecting the base characteristic code is the same as or matches an algorithm applied for obtaining the characteristic code. The present techniques determine whether the base characteristic code and the characteristic code correspond to a same human biological characteristic. If a result is positive, the identity authentication request is verified. The present techniques implement communication between different terminal devices of different manufacturers and effectively improve user experiences, thereby efficiently and conveniently implementing remote identity authentication.

LIGHT-TRANSMITTING DISPLAY PANEL, DISPLAY PANEL AND DISPLAY APPARATUS

A light-transmitting display panel, display panel and display apparatus. The light-transmitting display panel includes a first pixel array including a first minimum repeating unit. The first minimum repeating unit includes at least one light-transmitting column unit. The at least one light-transmitting column unit has a central axis parallel to an extending direction of the at least one light-transmitting column unit. The at least one light-transmitting column unit includes a plurality of first sub-pixels spaced apart from one another in the extending direction of the at least one light-transmitting column unit. At least one of the first sub-pixels in the at least one light-transmitting column unit is set to deviate from the central axis. 1. A light-transmitting display panel , comprising:a first pixel array comprising a first minimum repeating unit, the first minimum repeating unit comprising at least one light-transmitting column unit, the at least one light-transmitting column unit having a central axis parallel to an extending direction of the at least one light-transmitting column unit and comprising a plurality of first sub-pixels spaced apart from one another in the extending direction of the at least one light-transmitting column unit,wherein at least one of the first sub-pixels in the at least one light-transmitting column unit is set to deviate from the central axis.2. The light-transmitting display panel of claim 1 , wherein the plurality of first sub-pixels in the at least one light-transmitting column unit are arranged in a curved arrangement structure.3. The light-transmitting display panel of claim 1 , wherein the plurality of first sub-pixels in the at least one light-transmitting column units are arranged in an arcuate arrangement structure.4. The light-transmitting display panel of claim 1 , wherein in the first minimum repeating unit claim 1 , the at least one light-transmitting column unit comprises at least two light-transmitting column units ...

SYNTHETIC ANTIBODY MIMIC PEPTIDES

The present disclosure relates to compositions and methods comprising peptide molecules that mimic the binding and functional properties of native antibodies relative to their respective targets. Some embodiments comprise peptide-drug conjugates (PDCs) comprising the mimic peptides disclosed herein. The targets of these mimic peptides include epidermal growth factor receptor (EGFR), and human epidermal growth factor receptor 2 (HER2), vascular endothelial growth factor (VEGF), programmed cell death protein 1 (PD-1), and programmed death-ligand 1 (PD-L1). The present disclosure comprises application of the knob-socket computational model to design antibody mimics for proteins. 1. An isolated antibody mimic peptide comprising at least one of a motif sequence SEQ ID NO:78 or the reverse of said motif sequence , said motif sequence having Namino acids , wherein P is proline , W is tryptophan , E is glutamic acid , F is phenylalanine , Y is tyrosine , A is alanine , and each of X , X , X , Xand Xis any of 0 to 8 amino acids; and , wherein P is at amino acid position N/2 of the motif sequence or next thereto.2. The peptide of claim 1 , wherein the FY in the motif sequence is replaced with YW claim 1 , YL claim 1 , YI claim 1 , YV claim 1 , YF claim 1 , WY claim 1 , LY claim 1 , IY claim 1 , VY claim 1 , YY claim 1 , TYY claim 1 , TYW claim 1 , TYL claim 1 , TYI claim 1 , TYV claim 1 , TYF claim 1 , TWY claim 1 , TLY claim 1 , TIY claim 1 , TVY claim 1 , or TFY claim 1 , wherein L is leucine claim 1 , I is isoleucine claim 1 , and V is valine.3. The motif sequence of wherein the length of the sequence ranges from 7 to 25 amino acids.4. The motif sequence of wherein the sequence comprises 7 claim 2 , 10 claim 2 , 15 claim 2 , 20 claim 2 , or 25 amino acids.5. The peptide of claim 1 , wherein the peptide is conjugated to a substance.6. The peptide of claims 5 , wherein the substance is a therapeutic or a detective: agent.7. Method for diagnosing a disease comprising a ...

SYSTEM AND METHOD FOR ADDITIVELY MANUFACTURING BOILER TUBES

A method of manufacturing a tube is provided. The method includes: selecting a core pipe having a thickness that is initially less than a desired thickness of the tube; and building-up an outer layer over an exterior surface of the core pipe via additive manufacturing so as to increase the thickness of the core pipe such that the thickness of the core pipe is equal to the desired thickness of the tube. 1. A method of manufacturing a tube comprising:selecting a core pipe having a thickness that is initially less than a desired thickness of the tube; andbuilding-up an outer layer over an exterior surface of the core pipe via additive manufacturing so as to increase the thickness of the core pipe such that the thickness of the core pipe is equal to the desired thickness of the tube.2. The method of claim 1 , wherein building-up an outer layer over an exterior surface of the core pipe via additive manufacturing comprises:weld strip cladding the outer layer onto the exterior surface of the core pipe.3. The method of claim 1 , wherein the core pipe comprises a first material and the outer layer comprises a second material different from the first material.4. The method of further comprising:building fittings into the outer layer via additive manufacturing.5. The method of claim 4 , wherein the fittings include at least one of a nipple claim 4 , a nozzle claim 4 , a tee claim 4 , a weld-o-let claim 4 , an elbow claim 4 , and a reducer.6. The method of wherein the fitting defines a flow path and the method further comprises:boring through the outer layer and the core pipe such that the flow path is fluidly connected to an interior cavity of the core pipe.7. The method of further comprising:cutting the core pipe such that a length of the core pipe is equal to a desired length of the tube.8. The method of further comprising:extending a length of the core pipe via connecting the core pipe to another core pipe such that a combined length of the connected core pipes is equal to ...

CONTROLLED RELEASE DOSAGE FORM

The present invention generally relates to a pharmaceutical dosage form and controlled release of biologically active agents, diagnostic agents, reagents, cosmetic agents, and agricultural/insecticide agents. In one embodiment, the dosage form has a substrate that forms a compartment, wherein the substrate includes at least a first piece and a second piece, wherein the first piece operably links to the second piece. The dosage form contains a drug content that is loaded into the compartment. The dosage form also has a releaser operably linked to the substrate which upon contact with water or body fluid is capable of separating the first and second piece to open the compartment and release the drug content. 1. A solid pharmaceutical dosage form comprising:a substrate that forms a compartment, wherein the substrate comprises at least a first piece and a second piece, wherein the first piece operably links to the second piece;a drug content loaded into the compartment; anda releaser operably linked to the substrate which upon contact with water or body fluid is capable of separating said first and second piece to release the drug content.2. The dosage form of claim 1 , wherein the compartment has an aperture which is sealed by the releaser.3. The dosage form of claim 1 , wherein the releaser comprises a hydrogel.4. The dosage form of claim 1 , wherein the releaser comprises an effervescent material loaded in the compartment.5. The dosage form of claim 4 , wherein the effervescent material is selected from the group consisting of sodium carbonate claim 4 , sodium bicarbonate claim 4 , sodium metabisulphite claim 4 , calcium carbonate and combinations thereof.6. The dosage form of claim 1 , wherein the substrate is made from a thermoformable material.7. The dosage form of claim 4 , wherein the thermoformable material is selected from the group consisting of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer 57/30/13 claim 4 , polyvinylpyrrolidone ...

3D PRINTING DEVICE AND METHOD

A 3D printing device (), comprising a melt extrusion module (), a printing module (), and a platform module (). The melt extrusion module () comprises a processing chamber () consisting of a feed inlet () and a discharge outlet (), as well as an extrusion means () and a heating means () disposed at the processing chamber; the melt extrusion module () is configured to receive an initial material from the feed inlet () of the processing chamber (), and heat and extrude the initial material to convert the initial material into a molten body, which is extruded out of the discharge outlet () of the processing chamber (). The printing module () is communicated with the discharge outlet () of the processing chamber () and is provided with a nozzle (); the printing module () is configured to receive the molten body extruded from the discharge outlet () of the processing chamber () and guide the molten body to be extruded out of the nozzle (). The platform module () is configured to receive the molten body extruded from the nozzle (). 176-. (canceled)77. A 3D printing method of making a pharmaceutical dosage form , comprising:feeding a first initial pharmaceutical material to a processing chamber of a first melt extrusion module;heating and extruding the first initial pharmaceutical material in the processing chamber of the first melt extrusion module, so that the first initial pharmaceutical material is converted into a first melt and the first melt is extruded from a discharge outlet of the processing chamber of the first melt extrusion module; andguiding the first melt at the discharge outlet of the processing chamber of the first melt extrusion module to be extruded through a first nozzle of a first printing module and deposited on a platform module.78. The 3D printing method of claim 77 , further comprising:feeding the first initial pharmaceutical material to the first melt extrusion module through a hopper of a first feeding module; andcontrolling the discharge speed ...

IDENTITY AUTHENTICATION BY USING HUMAN BIOLOGICAL CHARACTERISTIC

A human biological characteristic file corresponding to a particular identity is received and used as a base file. A characteristic code to be authenticated is obtained according to a human biological characteristic of a person who requests identity authentication when an identity authentication request corresponding to the particular identity is received. A base characteristic code is collected from a base file. A collecting algorithm applied for collecting the base characteristic code is the same as or matches an algorithm applied for obtaining the characteristic code. The present techniques determine whether the base characteristic code and the characteristic code correspond to a same human biological characteristic. If a result is positive, the identity authentication request is verified. The present techniques implement communication between different terminal devices of different manufacturers and effectively improve user experiences, thereby efficiently and conveniently implementing remote identity authentication. 1. A method comprising:receiving a human biological characteristic file of a particular identity as a base file;receiving a request for an identity authentication corresponding to the particular identity;obtaining a first characteristic code corresponding to a human biological characteristic of a person who requests the identity authentication;collecting a second characteristic code from the base file by using a collecting algorithm for collecting the second characteristic code that matches a collecting algorithm for collecting the first characteristic code;determining whether the second characteristic code and the first characteristic code correspond to a same human biological characteristic; andverifying the request for the identity authentication in response to determining that the second characteristic code and the first characteristic code correspond to the same human biological characteristic.2. The method of claim 1 , wherein the obtaining ...

HIGH-THROUGHPUT AND HIGH-PRECISION PHARMACEUTICAL ADDITIVE MANUFACTURING SYSTEM

The present disclosure relates generally to manufacturing pharmaceutical products using additive manufacturing technology. An exemplary printing system comprises: a material supply module for receiving a set of printing materials; a flow distribution module comprising a flow distribution plate, wherein the material supply module is configured to transport a single flow corresponding to the set of printing materials to the flow distribution plate; wherein the flow distribution plate comprises a plurality of channels for dividing the single flow into a plurality of flows; a plurality of nozzles, wherein the plurality of nozzles comprises a plurality of needle-valve mechanisms; one or more controllers for controlling the plurality of needle-valve mechanisms to dispense the plurality of flows based on a plurality of nozzle-specific parameters; and a printing platform configured to receive the dispensed plurality of flows, wherein the printing platform is configured to move to form a batch of the pharmaceutical product. 1. A system for creating pharmaceutical products by additive manufacturing , comprising:a material supply module for receiving a set of printing materials; wherein the material supply module is configured to transport a single flow corresponding to the set of printing materials to the flow distribution plate;', 'wherein the flow distribution plate comprises a plurality of channels for dividing the single flow into a plurality of flows;, 'a flow distribution module comprising a flow distribution plate,'}a plurality of nozzles; andone or more controllers for controlling the plurality of nozzles to dispense the plurality of flows based on a plurality of nozzle-specific parameters.2. The system of claim 1 , further comprising a printing platform configured to receive the dispensed plurality of flows claim 1 , wherein the printing platform is configured to move to form a batch of the pharmaceutical product.3. (canceled)4. The system of claim 1 , wherein the ...

ELECTRIC VEHICLE CHASSIS AND ELECTRIC VEHICLE USING SAME

Disclosed are an electric vehicle chassis and an electric vehicle using the electric vehicle chassis. The electric vehicle chassis comprises a frame system (), a steering motor damping system (), a wheel system (), a steering system () and a braking system (), wherein the wheel system () comprises a left front wheel () using a hub motor, a left rear wheel () using a hub motor, a right front wheel () using a hub motor, and a right rear wheel () using a hub motor; and the steering motor damping system () comprises a left front steering damping motor (), a right front steering damping motor (), a left rear steering damping motor () and a right rear steering damping motor (). Driving the wheels with the hub motors can omit a traditional mechanical transmission system, so as to simplify the structure of the chassis, reduce the weight of the chassis, and also reduce the mechanical transmission loss, thereby improving the power utilization efficiency. 1. An electric vehicle chassis comprising a frame system , a steering motor damping system mounted on the frame system , a wheel system connected with the steering motor damping system , a steering system mounted on the frame system and a braking system mounted on the frame system , wherein the wheel system comprises a left front wheel using a hub motor , a left rear wheel using a hub motor , a right front wheel using a hub motor , and a right rear wheel using a hub motor; and the steering motor damping system comprises a left front steering damping motor , a right front steering damping motor , a left rear steering damping motor and a right rear steering damping motor; the left front steering damping motor and the right front steering damping motor are respectively disposed on a left side and a right side of a front end of the frame system , the left rear steering damping motor and the right rear steering damping motor are respectively disposed on the left side and the right side of a rear end of the frame system; the left ...

ORAL DRUG DOSAGE FORMS HAVING A DESIRED PK PROFILE AND METHODS OF DESIGNING AND PRODUCING THEREOF

The present disclosure, in some aspects, is directed to methods of designing an oral drug dosage form formulated and configured to have a desired pharmacokinetic profile. In other aspects, the present disclosure is directed to oral drug dosage forms having a desired pharmacokinetic profile, and methods of making, such as three-dimensional printing, such oral drug dosage forms. 171-. (canceled)73: The method of claim 72 , wherein the individual is a human.74: The method of claim 72 , wherein the drug has linear pharmacokinetics.75: The method of claim 72 , wherein the MR1 portion is a MR1 layer.76: The method of claim 72 , wherein the MR2 portion is a MR2 layer.77: The method of claim 72 , wherein the MR1 portion is an immediate-release (IR) portion having an immediate-release profile claim 72 , and wherein the MR2 portion is an extended-release (ER) portion having an extended-release profile.78: The method of claim 72 , wherein the MR1 portion is a first extended-release (ER) portion having an extended-release profile claim 72 , and wherein the MR2 portion is a second extended-release (ER) portion having an extended-release profile.79: The method of claim 72 , wherein the MR1 portion is a first immediate-release (IR) portion having an immediate-release profile claim 72 , and wherein the MR2 portion is a second immediate-release (IR) portion having an immediate release profile.80: The method of claim 77 , wherein the MR1 portion and the MR2 portion are stacked on top of each other.81: The method of claim 80 , wherein the MR1 portion and MR2 portion are partially surrounded by a shell claim 80 , and wherein the shell has a slower dissolution rate than the ER portion.82: The method of claim 81 , wherein the shell comprises an enteric material.83: The method of claim 80 , wherein the MR1 portion has a top surface and a bottom surface claim 80 , wherein the MR2 portion has a top surface and a bottom surface claim 80 , and wherein the shell is in direct contact with both ...

ORAL DRUG DOSAGE FORM COMPRISING DRUG IN THE FORM OF NANOPARTICLES

The present disclosure provides a stable solid pharmaceutical dosage form for oral administration. The dosage form includes a substrate that forms at least one compartment and a drug content loaded into the compartment. The dosage form is so designed that the active pharmaceutical ingredient of the drug content is released in a controlled manner. 1. A tablet comprising a plurality of layers , wherein each layer comprises a substrate , and wherein the table comprises a drug in the form of nanoparticles disposed between at least two of the plurality of layers.2. The tablet of claim 1 , comprising a first layer claim 1 , a second layer claim 1 , a third layer claim 1 , a first drug in the form of nanoparticles disposed between the first layer and the second layer claim 1 , and a second drug in the form of nanoparticles disposed between the second layer and the third layer.3. The tablet of claim 2 , wherein the first drug and the second drug are different.4. The tablet of claim 2 , wherein the first drug and the second drug are the same.5. The tablet of claim 1 , wherein the substrate is erodible.6. The table of claim 1 , wherein the substrate thickness is different among each layer.7. The tablet of claim 1 , wherein the substrate thickness is the same among each layer.8. The tablet of claim 1 , wherein the substrate comprises a drug embedded therein.9. The tablet of claim 8 , wherein the drug embedded within the substrate of each layer is different.10. The tablet of claim 8 , wherein the drug embedded within the substrate of each layer is the same.11. The tablet of claim 1 , wherein the size of the nanoparticles is from about 1 nm to about 900 nm.12. The tablet of claim 1 , wherein the size of the nanoparticles is from about 100 nm to about 500 nm.13. The tablet of claim 1 , wherein the size of the nanoparticles is from about 100 nm to about 200 nm.1421-. (canceled)22. The tablet of claim 2 , wherein the substrate of each layer is erodible.23. The tablet of claim 2 , ...

ENHANCED ANTICANCER AGENT

The teachings provide methods of delivering active agents that are conjugated with delivery systems that increase the half-life, and reduce the immunogenicity, of the active agents. Delivery systems and methods of making and using the delivery systems are also provided. The delivery systems have (i) a ligand that is selective for an endogeneous plasma protein in the serum of a subject; and, (ii) a linker configured for operatively attaching the ligand covalently to an active agent to increase the half-life of the active agent in the serum. 4. The enhanced anticancer agent of claim 1 , the agent having an increased half-life in blood serum when conjugated to the delivery system.5. The enhanced anticancer agent of claim 1 , the agent having a reduced immunogenicity in blood serum when conjugated to the delivery system.6. The enhanced anticancer agent of claim 2 , the agent having an increased half-life in blood serum when conjugated to the delivery system.7. The enhanced anticancer agent of claim 2 , the agent having a reduced immunogenicity in blood serum when conjugated to the delivery system.8. The enhanced anticancer agent of claim 3 , the agent having an increased half-life in blood serum when conjugated to the delivery system.9. The enhanced anticancer agent of claim 3 , the agent having a reduced immunogenicity in blood serum when conjugated to the delivery system.10. The enhanced anticancer agent of claim 1 , wherein the linker claim 1 , R claim 1 , attaches (i) to the ligand through an ether bond and (ii) to the active agent through an amide bond.11. The enhanced anticancer agent of claim 1 , wherein the linker claim 1 , R claim 1 , attaches (i) to the ligand through an ether bond and (ii) to the active agent through an ester bond.12. A method of administering an enhanced anticancer agent to a subject claim 1 , the method comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'obtaining the enhanced anticancer agent of ; and,'}administering the ...

ORAL DRUG DOSAGE FORM COMPRISING DRUG IN THE FORM OF NANOPARTICLES

The present disclosure provides a stable solid pharmaceutical dosage form for oral administration. The dosage form includes a substrate that forms at least one compartment and a drug content loaded into the compartment. The dosage form is so designed that the active pharmaceutical ingredient of the drug content is released in a controlled manner. 1. An oral drug dosage form comprising a plurality of layers , wherein each layer comprises a substrate , and wherein the oral drug dosage form comprises a drug in the form of nanoparticles disposed between at least two of the plurality of layers.2. The oral drug dosage form of claim 1 , comprising a first layer claim 1 , a second layer claim 1 , a third layer claim 1 , a first drug in the form of nanoparticles disposed between the first layer and the second layer claim 1 , and a second drug in the form of nanoparticles disposed between the second layer and the third layer.3. The oral drug dosage form of claim 2 , wherein the first drug and the second drug are different.4. The oral drug dosage form of claim 2 , wherein the first drug and the second drug are the same.5. The oral drug dosage form of claim 1 , wherein the substrate is erodible.6. The oral drug dosage form of claim 1 , wherein the substrate thickness is different among each layer.7. The oral drug dosage form of claim 1 , wherein the substrate thickness is the same among each layer.8. The oral drug dosage form of claim 1 , wherein the substrate comprises a drug embedded therein.9. The oral drug dosage form of claim 8 , wherein the drug embedded within the substrate of each layer is different.10. The oral drug dosage form of claim 8 , wherein the drug embedded within the substrate of each layer is the same.11. The oral drug dosage form of claim 1 , wherein the size of the nanoparticles is from about 1 nm to about 900 nm.12. The oral drug dosage form of claim 1 , wherein the size of the nanoparticles is from about 100 nm to about 500 nm.13. The oral drug dosage ...

Backlight module

Disclosed is a backlight module. The backlight module includes a backplane. The backplane is provided with a groove therethrough. Two sides and/or two ends of an optical diaphragm of the backlight module each are connected with a bendable flap which passes through the groove and is attached to the backplane. The backlight module has a simple structure without a plastic frame or a frame sealant, and an optical diaphragm in the backlight module can be fixed. A super narrow frame of the backlight module can be realized.

Synthetic antibody mimic peptides

The present disclosure relates to compositions and methods comprising peptide molecules that mimic the binding and functional properties of native antibodies relative to their respective targets. Some embodiments comprise peptide-drug conjugates (PDCs) comprising the mimic peptides disclosed herein. The targets of these mimic peptides include epidermal growth factor receptor (EGFR), and human epidermal growth factor receptor 2 (HER2), vascular endothelial growth factor (VEGF), programmed cell death protein 1 (PD-1), and programmed death-ligand 1 (PD-L1). The present disclosure comprises application of the knob-socket computational model to design antibody mimics for proteins.

MULTI-CHAMBER TIRE MANUFACTURING MOLD

A multi-chamber tire manufacturing mold, comprising an upper holding plate and a lower holding plate having an interval between the upper holding plate and the lower holding plate; a tire periphery forming slider, a tire inner chamber forming slider, an upper mold block, a lower mold block, and a central mold post are arranged in the interval; the upper holding plate is connected to the plurality of upper mold blocks, and the lower holding plate is connected to a plurality of lower mold blocks, forming an enclosed chamber; the tire inner chamber forming slider arranged in the enclosed chamber, forming a flexible portion chamber and a partitioned chamber, such that isolating chambers are formed in the flexible portion; the openings of which together with the tire periphery forming slider form an enclosed chamber via process sealing members and fill the forming outer body. 1. A multi-chamber tire manufacturing mold , wherein the multi-chamber tire manufacturing mold comprises an upper holding plate and a lower holding plate; the upper holding plate and the lower holding plate are arranged alternately and in parallel with each other with intervals between the upper holding plate and the lower holding plate;a plurality of tire periphery forming sliders, upper mold blocks, lower mold blocks and central mold posts are arranged in the intervals; the tire periphery forming sliders are arranged along the height direction of the intervals, and the plurality of tire periphery forming sliders are connected in order and arranged in an annular fashion; the central mold posts are arranged along the height direction of the intervals in an annular fashion, and located at an inner side of the plurality of tire periphery forming sliders, and arranged alternately with the plurality of tire periphery forming sliders; the central mold post is configured inside with a forming part which is arranged around the central mold post;a lower end of the upper holding plate is connected with a ...

METHOD AND SYSTEM FOR EXTRACTING CHARACTERISTIC INFORMATION

Extracting characteristic information includes receiving a collection command from a client, obtaining, via a collection device, biometric information based on the collection command, selecting a stored extraction algorithm corresponding to the client, the stored extraction algorithm being selected from among a plurality of stored extraction algorithms, extracting characteristic values from the obtained biometric information, the characteristic values being extracted based on the selected extraction algorithm, and sending the extracted characteristic values to the client. 1. A system , comprising:a receiving module configured to receive a collection command from a client;an information obtaining module configured to obtain, via a collection device, biometric information based on the collection command;a function extracting module configured to select an extraction algorithm corresponding to the client, the selected extraction algorithm being selected from among a plurality of stored extraction algorithms;a characteristic value extracting module configured to extract characteristic values from the biometric information, the characteristic values being extracted based on the selected extraction algorithm; anda sending module configured to send the extracted characteristic values to the client.2. The system as described in claim 1 , wherein the information obtaining module is further configured to:send the collection command to the collection device; andreceive the biometric information collected by the collection device after the receiving module performs collection.3. The system as described in claim 1 , wherein the function extracting module is further configured to determine the extraction algorithm corresponding to identifying information of the client claim 1 , the identifying information of the client being included in the collection command.4. The system as described in claim 1 , wherein:a storage module is configured to acquire the extraction algorithm ...

VARIABLE FREQUENCY DRIVE CIRCUIT WITH OVERVOLTAGE PROTECTION

A variable frequency drive (VFD) circuit includes an input connectable to an AC source, a rectifier to convert an AC power input to a DC power, a DC link to receive DC power from the rectifier and having a DC link voltage thereon, a DC link capacitor bank with one or more capacitors connected to the DC link, and a pre-charge circuit coupled to the DC link capacitor. The pre-charge circuit further includes one or more resistors, one or more pre-charge relays each operable in on and off states to selectively control a current flow through the resistor(s) so as to control an initial pre-charge of the DC link capacitor, and an overvoltage relay operable in on and off states to selectively cut-off a current flow to the DC link capacitor bank, so as to prevent an overvoltage condition in the DC link capacitor bank. 1. A variable frequency drive (VFD) circuit comprising:an input connectable to an AC source;a rectifier connected to the input to convert an AC power input to a DC power;a DC link coupled to the rectifier to receive the DC power therefrom, the DC link having a DC link voltage thereon;a DC link capacitor bank comprising one or more capacitors connected to the DC link to smooth the DC link voltage; and one or more resistors;', 'one or more pre-charge relays each operable in an on and off state to selectively control a current flow through the one or more resistors, so as to control an initial pre-charge of the DC link capacitor; and', 'an overvoltage relay operable in an on and off state to selectively cut-off a current flow to the DC link capacitor bank, so as to prevent an overvoltage condition in the DC link capacitor bank., 'a pre-charge circuit coupled to the DC link capacitor bank, the pre-charge circuit comprising2. The VFD circuit of further comprising:one or more voltage sensors to measure the DC link voltage; anda controller that receives an input from the one or more voltage sensors regarding the measured DC link voltage, the controller being ...

DRIVE SYSTEM WITH COMMON DC BUS

A system includes: a pre-charge circuit configured to produce direct current (DC) electrical power; a common DC bus; and a plurality of inverters, each inverter including: a local DC bus; a capacitor network connected to the local DC bus; an electrical network connected to the local DC bus, the electrical network configured to generate an alternating current (AC) drive signal; and a plurality of switching assemblies, each switching assembly being associated with one of the inverters, and each switching assembly configured to control whether the local DC bus and the capacitor network of the associated inverter are electrically connected to the common DC bus or to the pre-charge circuit. 1. A system comprising:a pre-charge circuit configured to produce direct current (DC) electrical power;a common DC bus; and a local DC bus;', 'a capacitor network connected to the local DC bus;', 'an electrical network connected to the local DC bus, the electrical network configured to generate an alternating current (AC) drive signal; and, 'a plurality of inverters, each inverter comprisinga plurality of switching assemblies, each switching assembly being associated with one of the inverters, and each switching assembly configured to control whether the local DC bus and the capacitor network of the associated inverter are electrically connected to the common DC bus or to the pre-charge circuit.2. The system of claim 1 , wherein the pre-charge circuit is configured to provide DC electrical power to the capacitor network of the local DC bus of at least one of the plurality of inverters while the local DC bus of at least one other of the plurality of inverters is electrically connected to the common DC bus.3. The system of claim 1 , wherein the pre-charge circuit is electrically connected to an AC electrical power source and further comprises at least one electronic element configured to convert AC electrical power to DC electrical power.4. The system of claim 3 , wherein the at least ...

Porous layered transition metal dichalcogenide and preparation method and use thereof

The present invention relates to the field of catalysts, and provides a porous layered transition metal dichalcogenide (TMD) and a preparation method and use thereof. The preparation method includes the following steps: (1) mixing silica microspheres, a transition metal salt and an elemental chalcogen, and pressing to obtain a tablet, the silica microspheres having a same or different particle diameters; and (2) sintering the tablet under hydrogen, and removing the silica microspheres to obtain the porous layered TMD. The porous layered TMD prepared by the method of the present invention has a high lattice edge exposure, which provides more active sites and higher catalytic activity, so the porous layered TMD can effectively catalyze the oxidation of alcohols to aldehydes or sulfides to sulfoxides under visible light irradiation.

3D PRINTING METHODS FOR COMPARTMENTED PHARMACEUTICAL DOSAGE FORMS

The present disclosure provides a stable solid pharmaceutical dosage form for oral administration. The dosage form includes a substrate that forms at least one compartment and a drug content loaded into the compartment. The dosage form is so designed that the active pharmaceutical ingredient of the drug content is released in a controlled manner. 2. The method of claim 1 , further comprising providing the API in a solid form and melting the API.3. The method of claim 2 , wherein the API is in a powdered form.4. The method of claim 2 , further comprising mixing the API with the first erodible material.5. The method of claim 1 , wherein the first erodible material and the second erodible material are the same.6. The method of claim 1 , wherein the first erodible material and the second erodible material are different.7. The method of claim 1 , wherein the first erodible material comprises a water-soluble thermoplastic material claim 1 , a plasticizer claim 1 , or a combination thereof.8. The method of claim 1 , wherein the second erodible material is selected from the group consisting of a water-soluble polymer claim 1 , an erodible or dissolvable polymer claim 1 , a wax claim 1 , a saccharide claim 1 , a plasticizer claim 1 , and a combination thereof.9. The method of claim 1 , wherein the substrate comprises a water-insoluble thermoplastic material.10. The method of claim 1 , wherein the API is tofacitinib.11. The method of claim 1 , further comprising providing a computer-aided 3D design of the oral dosage form for 3D printing.12. The method of claim 1 , wherein the melted substrate is deposited before the deposition of the extruded homogeneous melted mixture.13. The method of claim 1 , wherein the second erodible material is deposited after the deposition of the extruded homogenous melted mixture. This application is a continuation of U.S. patent application Ser. No. 16/402,028, filed May 2, 2019, which is a continuation of U.S. patent application Ser. No. 16/289, ...

ORAL DRUG DOSAGE FORM COMPRISING VARIOUS RELEASE PROFILES

The present disclosure provides a stable solid pharmaceutical dosage form for oral administration. The dosage form includes a substrate that forms at least one compartment and a drug content loaded into the compartment. The dosage form is so designed that the active pharmaceutical ingredient of the drug content is released in a controlled manner. 1. An oral drug dosage form comprising:a) a first substrate forming a first layer comprising a first drug embedded therein, andb) a second substrate forming a second layer comprising a second drug embedded therein,wherein the first layer and the second layer are stacked together,wherein upon exposure to gastrointestinal fluid the first drug is released according to a first drug release profile and the second drug is released according to a second drug release profile,wherein the first drug release profile is an immediate-release (IR) profile, andwherein the second drug release profile is an extended-release (ER) profile.2. The oral drug dosage form of claim 1 , wherein the first drug and the second drug are different.3. The oral drug dosage form of claim 1 , wherein the first drug and the second drug are the same.4. The oral drug dosage form of claim 3 , wherein the first drug and the second drug are both topiramate.5. The oral drug dosage form of claim 1 , further comprising a third substrate forming a third layer comprising a third drug embedded therein claim 1 , wherein upon exposure to gastrointestinal fluid the third drug is released according to a third drug release profile.6. The oral drug dosage form of claim 5 , wherein the third drug is different from the first drug and/or the second drug.7. The oral drug dosage form of claim 5 , wherein the third drug is the same as the first drug and/or the second drug.8. The oral drug dosage form of claim 5 , wherein the third drug release profile is different from the first drug release profile and/or the second drug release profile.9. The oral drug dosage form of claim 5 , ...

DOSAGE FORMS AND USE THEREOF

The present disclosure provides a stable solid pharmaceutical dosage form for oral administration. The dosage form includes a substrate that forms at least one compartment and a drug content loaded into the compartment. The dosage form is so designed that the active pharmaceutical ingredient of the drug content is released in a controlled manner. 1. A dosage form comprising:a substrate that forms a compartment; anda drug content loaded into the compartment.2. The dosage form of claim 1 , wherein the drug content is operably linked to the substrate.3. The dosage form of claim 1 , wherein the drug content is detached from the substrate.4. The dosage form of claim 1 , wherein the substrate is made from at least one thermoplastic material.5. The dosage form of claim 4 , wherein the thermoplastic material is selected from the group consisting of a hydrophilic polymer claim 4 , a hydrophobic polymer claim 4 , a swellable polymer claim 4 , a non-swellable polymer claim 4 , a porous polymer claim 4 , a non-porous polymer claim 4 , an erodible polymer claim 4 , a non-erodible polymer.6. The dosage form of claim 1 , wherein the compartment has a shape selected from the group consisting of a pie shape claim 1 , a cone shape claim 1 , a pyramid shape claim 1 , a cylindrical shape claim 1 , a cubic or cuboidal shape claim 1 , a triangular or polygonal prism shape claim 1 , a tetrahedron and a combination thereof.7. The dosage form of claim 1 , wherein the drug content comprises an active pharmaceutical ingredient (API).8. The dosage form of claim 7 , wherein the drug content further comprises a medium.9. The dosage form of claim 8 , wherein the medium is made from a thermoplastic material.10. The dosage form of claim 8 , wherein the medium has a higher erosion/dissolution rate than the API.11. The dosage form of claim 8 , wherein the medium has a higher erosion/dissolution rate than the substrate.12. The dosage form of claim 1 , wherein the compartment has an aperture which is ...

CONTROL AND PROTECTION APPARATUS FOR ELECTRIC MOTOR

A control and protection apparatus for an electric motor, comprising an inverter (), a first converter (), a temperature detection apparatus (), and a second converter (). The first converter () is used for generating, on the basis of an input signal, a first control signal to control working of the inverter (). The temperature detection apparatus () is used for detecting the temperature of the electric motor () and for acquiring a temperature signal. The second converter () is used for generating a second control signal on the basis of the temperature signal detected and for providing the second control signal to the inverter (). The inverter () is used for controlling wording of the electric motor () on the basis of the first control signal and of the second control signal. The control and protection apparatus for the electric motor is low in costs and high in safety and reliability. 1. A control and protection apparatus for an electric motor , characterized in that the control and protection apparatus for the electric motor comprises a frequency transformer , a first converter , a temperature-detection device and a second converter , wherein the first converter is configured to generate a first control signal from an input signal to control the operation of the frequency transformer , the temperature-detection device is configured to detect the temperature of the electric motor and generate a temperature signal , the second converter is configured to generate a second control signal from the temperature signal , and provide the second control signal to the frequency transformer , and the frequency transformer is configured to control the operation of the electric motor based on the first control signal and the second control signal.2. The control and protection apparatus for the electric motor according to claim 1 , wherein the frequency transformer comprises a switch tube driver and an inverter claim 1 , and the switch tube driver is configured to provide a ...

Precision pharmaceutical 3d printing device

Provided herein are devices and systems for depositing a material or manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. Further provided are methods of using the devices and systems, as well as methods of manufacturing a product, such as a pharmaceutical dosage form, by additive manufacturing. In certain embodiments, the device includes a material supply system configured to melt an pressurized a material, a pressure sensor configured to detect a pressure of the material within the device, and a control switch comprising a sealing needle operable in an open position and closed position. The sealing needle extends through a feed channel containing the material and includes a taper end, wherein the tapered end of the sealing needle engages a tapered inner surface of a nozzle to inhibit flow of the material through the nozzle when the sealing needle is in the closed position.

SIDE-LIGHTING LIGHT GUIDE PLATE AND BACKLIGHT MODULE

This disclosure provides a side-lighting light guide plate and a backlight module. The side-lighting light guide plate comprises a light guide component having a first light incident surface and a light emitting surface that intersects with the first light incident surface; a plurality of first light guide columns disposed on the first light incident surface to guide light into the light guide component; the light emitting surface configured to emit the light. 1. A side-lighting light guide plate , wherein the side-lighting light guide plate comprises a light guide component having a first light incident surface and a light emitting surface that intersects with the first light incident surface;a plurality of first light guide columns disposed on the first light incident surface, to guide light into the light guide component;the light emitting surface configured to emit the light.2. The side-lighting light guide plate as claimed in claim 1 , wherein the plurality of first light guide columns are perpendicular to the first light incident surface.3. The side-lighting light guide plate as claimed in claim 1 , wherein the plurality of first light guide columns are parallel to the light emitting surface and are sequentially arranged on the first light incident surface.4. The side-lighting light guide plate as claimed in claim 3 , wherein the plurality of first light guide columns are disposed along a same interval.5. The side-lighting light guide plate as claimed in claim 1 , wherein the plurality of first light guide columns are cylindrical.6. The side-lighting light guide plate as claimed in claim 5 , wherein a height of the plurality of first light guide columns is 5-10 times of a diameter of the plurality of first light guide columns.7. The side-lighting light guide plate as claimed in claim 1 , wherein the light guide component has a second light incident surface that intersects with the light emitting surface;the plurality of first light guide columns and/or a ...

Plastic frame for backlight module and backlight module, and liquid crystal display module

The present disclosure provides a plastic frame for a backlight module. The plastic frame includes a glass cover plate, and edge bars including a first edge bar provided with an LED placing groove for insertion of lamp beads of the light bars and a second edge bar, that are provided at two opposite sides of the glass cover plate close to an edge, respectively, wherein the LED placing groove passes through one side of the first edge bar being opposite to the second edge bar and one side of the first edge bar deviating away from the second edge bar. The present disclosure also provides a backlight module and a liquid crystal display module.

DELIVERING ENHANCED ACTIVE AGENTS

The teachings provide methods of delivering active agents that are conjugated with delivery systems that increase the half-life, and reduce the immunogenicity, of the active agents. Delivery systems and methods of making and using the delivery systems are also provided. The delivery systems have (i) a ligand that is selective for an endogeneous plasma protein in the serum of a subject; and, (ii) a linker configured for operatively attaching the ligand covalently to an active agent to increase the half-life of the active agent in the serum. 4. The method of claim 1 , further comprising selecting the active agent to have a structure selected from the group consisting of a peptide claim 1 , an oligopeptide claim 1 , a polypeptide claim 1 , a protein claim 1 , an antibody claim 1 , an oligonucleotide claim 1 , a polynucleotide claim 1 , a virus-like particle claim 1 , a small molecule claim 1 , an oligosaccharide claim 1 , an imaging agent claim 1 , and combinations thereof.5. The method of further comprising increasing the half-life of the active agent in blood serum after the administering.6. The method of further comprising reducing the immunogenicity of the active agent in blood serum after the administering.7. The method of further comprising increasing the half-life of the active agent in blood serum after the administering.8. The method of further comprising reducing the immunogenicity of the active agent in blood serum after the administering.9. The method of further comprising increasing the half-life of the active agent in blood serum after the administering.10. The method of further comprising reducing the immunogenicity of the active agent in blood serum after the administering.11. The method of further comprising increasing the half-life of the active agent in blood serum after the administering.12. The method of further comprising reducing the immunogenicity of the active agent in blood serum after the administering.13. The method of claim 1 , wherein the ...

DISPLAY SCREEN, DISPLAY DEVICE AND METHOD FOR MANUFACTURING A DISPLAY SCREEN

The present application relates to a display screen, a display device and a method for manufacturing a display screen. The display screen comprises a contour line and an active display region. The active display region includes an edge display region close to the contour line and a main display region away from the contour line. The edge display region and the contour line are intersected. The display screen includes a light-emitting layer and a light-outputting layer having a first region, the first region of the light-outputting layer has a scattering structure provided thereon. Light emitted from the light-emitting layer is deviated from an original propagation direction after passing through the scattering structure. The first region is formed into at least a partial region on the light-outputting layer corresponding to the edge display region. 1. A display screen , whereinthe display screen comprises a contour line, and an active display region,the active display region comprises an edge display region close to the contour line and a main display region away from the contour line, andthe edge display region and the contour line are intersected; andwherein the display screen comprises a light-emitting layer and a light-outputting layer having a first region,the first region of the light-outputting layer has a scattering structure provided thereon,light emitted from the light-emitting layer is deviated from an original propagation direction after passing through the scattering structure, andthe first region is formed into at least a partial region of the light-outputting layer corresponding to the edge display region.2. The display screen according to claim 1 , wherein a projection of the first region on a substrate of the display screen is a first projection claim 1 , a projection of the edge display region on the substrate of the display screen is a second projection claim 1 , and the first projection overlaps the second projection.3. The display screen ...

Enhanced sn-38 anticancer agent

The teachings provide methods of delivering active agents that are conjugated with delivery systems that increase the half-life, and reduce the immunogenicity, of the active agents. Delivery systems and methods of making and using the delivery systems are also provided. The delivery systems have (i) a ligand that is selective for an endogeneous plasma protein in the serum of a subject; and, (ii) a linker configured for operatively attaching the ligand covalently to an active agent to increase the half-life of the active agent in the serum.

LIQUID CRYSTAL DISPLAY AND BACKLIGHT MODULE THEREOF

A liquid crystal display and a backlight module thereof are provided. The backlight module includes a backlight source and a light guide plate. The backlight source is disposed at a side surface of the light guide plate. The light guide plate has an accommodation section for accommodating a functional module. The backlight module includes a compensation light source that is disposed on the light guide plate. The accommodation section is located between the backlight source and the compensation light source. The backlight module includes a compensation light source, and the backlight source and the compensation light source are located at two opposite sides of the accommodation section. The compensation light source may compensate for the illumination light in the light guide plate blocked by the functional module, so as to solve the non-uniform display problem of blocking the illumination light from the backlight source by the functional module. 1. A backlight module comprising a backlight source and a light guide plate , wherein the backlight source is disposed at a side surface of the light guide plate , the light guide plate has an accommodation section for accommodating a functional module , the backlight module further comprises a compensation light source that is disposed on the light guide plate , and the accommodation section is located between the backlight source and the compensation light source.2. The backlight module according to claim 1 , wherein the compensation light source comprises a flexible circuit board and one or more light emitting diode (LED) lamps that are disposed on the flexible circuit board claim 1 , the light guide plate has a mounting section for accommodating the one or more LED lamps claim 1 , and the flexible circuit board leans against a bottom surface of the light guide plate.3. The backlight module according to claim 2 , wherein a side of the flexible circuit board toward the accommodation section coincides with an edge of the ...

Copolymer of (meth)acryloxy-alkyl-siloxysilane and alkyl(meth)acrylates and the use thereof as pressure sensitive adhesives

A new polymer, the feed monomers and molar percents of which, exclusive of a polymerization initiator and crosslinker, are: A. (I) 42 mole % to 58 mole % of a siloxy silane of formula I, (II) 42 mole % to 58 mole % of an unsubstituted alkyl (meth)acrylate of formula II, (III) 0 to 5 mole % of a Group A monomer, and (IV) 0 to 16 mole % of an additional vinylic copolymerizable monomer; B. (I) 42 mole % to 58 mole % of a siloxy silane of formula I, (II) 21 mole % up to less than 42 mole % of an unsubstituted alkyl (meth)acrylate of formula II, (III) 0 to 5 mole % of a Group A monomer, and (IV) 0 to 29 mole % of an additional vinylic copolymerizable monomer, or C. (I) 16 mole % up to less than 42 mole % of a siloxy silane of formula I, (II) 42 mole % of 58 mole % of an unsubstituted alkyl (meth)acrylate of formula II, (III) 0 to 5 mole % of a Group A monomer, and (IV) 0 to 36 mole % of an additional vinylic copolymerizable monomer, where formula I is ##STR1## where formula II is ##STR2## where Group A is a vinylic acid or a (meth)acrylate as defined herein. Methods of manufacture of the polymer and the use thereof as a pressure adhesive, especially a transdermal and/or transmucosal delivery system pressure sensitive adhesive, are also claimed.

Systems for stabilizing and delivering active agents

A delivery system for active agents, and methods of making and using the systems, are provided. The delivery systems have (i) a ligand that is selective for an endogeneous plasma protein in the serum of a subject; and, (ii) a linker configured for operatively attaching the ligand covalently to an active agent to increase the half-life of the active agent in the serum.

Copolymer of (meth)acryloxy-alkyl-siloxysilane and alkyl(meth)acrylates and the use thereof as pressure sensitive adhesives

A new polymer, the feed monomers and molar percents of which, exclusive of a polymerization initiator and crosslinker, are: A. (I) 42 mole % to 58 mole % of a siloxy silane of formula I, (II) 42 mole % to 58 mole % of an unsubstituted alkyl (meth)acrylate of formula II, (III) 0 to 5 mole % of a Group A monomer, and (IV) 0 to 16 mole % of an additional vinylic copolymerizable monomer; B. (I) 42 mole % to 58 mole % of a siloxy silane of formula I, (II) 21 mole % up to less than 42 mole % of an unsubstituted alkyl (meth)acrylate of formula II, (III) 0 to 5 mole % of a Group A monomer, and (IV) 0 to 29 mole % of an additional vinylic copolymerizable monomer; or C. (I) 16 mole % up to less than 42 mole % of a siloxy silane of formula I, (II) 42 mole % to 58 mole % of an unsubstituted alkyl (meth)acrylate of formula II, (III) 0 to 5 mole % of a Group A monomer, and (IV) 0 to 36 mole % of an additional vinylic copolymerizable monomer; where formula I is ##STR1## where formula II is ##STR2## in which R 3 is hydrogen or methyl; and R 4 is methyl or a linear or branched chain C 2-10 alkyl which is unsubstituted; where Group A is (meth)acrylic acid, maleic acid, fumaric acid, itaconic acid, itaconic acid, cinnamic acid, crotonic acid, fumaric acid, maleic acid, 2-(methy)acroyloxyethyl sulfonic acid, 2-(meth)acrylamido-2-methylpropane sulfonic acid, vinyl sulfonic acid, p-styrene sulfonioc acid, allyl sulfonic acid or of formula III.

Polymer prepared from silanyl-silyloxy-alkyl(meth)acrylate and alkyl(meth)acrylate monomers and optionally other minor amounts of other monomers

A new polymer has a polymerisation feed mixt. of (a) a polymerisation initiator, (G) 0-5 mole.% based on the total of all monomers, present, of a vinylic copolymerisation crosslinker, and (c) one of the following mixt. (i) or (iii) where (i) is (I), 42-58 mole % of siloxy silane of formula (I), (II) 42-58 mole % of an unsubstd. alkyl (meth)acrylate of formula (II), (III) 0-5 mole % of a Gp. A monomer, and (IV) 0-16 mole % of an additional vinylic copolymerisable monomer of Gp. B, or where (iii) is (I) 16-42 mole % of siloxysilane I, (II) 42-58 mole % of alkyl (meth)acrylate II, (III) 0-5 mole % of a Gp A monomer and (IV) 0-36 mole % of a Gp B monomer. In the formulae, R1 = H or CH3; R2 = 1-6C alkylene; n = 0-2; R3 = H or CH3; R4 = CH3 or linear or branched 2-10C unsubstd. alkyl. Gp. A monomers are (meth)acrylic acid, maleic acid, fumaric acid, itaconic acid, cinnamic acid, crotonic acid, 2-(meth)acryloxyloxyethyl sulphonic acid, 2-(meth) acrylamido -2-methylpropane sulphonic acid, vinyl sulphonic acid, p-styrene sulphonic acid, allyl sulphonic acid and monomers of the formula (III). (R5 = H or CH3; R6 = 1-10C linear or branched alkyl, opt. substd. by CH, 1-4C alkoxy, Cl, Br, F, CO2H, 1-4C alkoxycarbonyl, 1-4C alkylcarbonyloxy or NH2). Gp. B monomer is neither a polymerisation inhibitor, a cross-linker nor a cpd. of formula (I) or (II) nor a Gp A monomer, but is a mono-satd. monomer copolymerisable with (I), (II) or Gp A cpds.

Controlled release dosage form

The present invention generally relates to a pharmaceutical dosage form and controlled release of biologically active agents, diagnostic agents, reagents, cosmetic agents, and agricultural/insecticide agents. In one embodiment, the dosage form has a substrate that forms a compartment, wherein the substrate includes at least a first piece and a second piece, wherein the first piece operably links to the second piece. The dosage form contains a drug content that is loaded into the compartment. The dosage form also has a releaser operably linked to the substrate which upon contact with water or body fluid is capable of separating the first and second piece to open the compartment and release the drug content.

Synthetic antibody mimic peptides

The present disclosure relates to compositions and methods comprising peptide molecules that mimic the binding and functional properties of native antibodies relative to their respective targets. Some embodiments comprise peptide-drug conjugates (PDCs) comprising the mimic peptides disclosed herein. The targets of these mimic peptides include epidermal growth factor receptor (EGFR), and human epidermal growth factor receptor 2 (HER2), vascular endothelial growth factor (VEGF), programmed cell death protein 1 (PD-1), and programmed death-ligand 1 (PD-L1). The present disclosure comprises application of the knob-socket computational model to design antibody mimics for proteins.

Dosage forms and use thereof

Multi-chamber tire manufacturing mold

A multi-chamber tire manufacturing mold, comprising an upper holding plate (11) and a lower holding plate (13) having an interval between the upper holding plate (11) and the lower holding plate (14); a tire periphery forming slider (16), a tire inner chamber forming slider (17), an upper mold block (121), a lower mold block (122), and a central mold post (18) are arranged in the interval; the upper holding plate (11) is connected to the plurality of upper mold blocks (121), and the lower holding plate (13) is connected to a plurality of lower mold blocks (122), forming an enclosed chamber (10); the tire inner chamber forming slider (17) is arranged in the enclosed chamber (10), forming a flexible portion chamber (101) and a partitioned chambers (171), such that a plurality of isolating chambers (25) are formed in the flexible portion (21); the openings of the isolating chambers (25) together with the tire periphery forming slider (16) form an enclosed chamber via process sealing members and fill the forming outer body (22). A tire flexible portion manufactured by the mold is provided with a plurality of enclosed isolating chambers, and can withstand multiple punctures and still meet the demands of high-speed run, thus the service life and performance of the tire are improved.

Conjugation of pharmaceutically active agents with transthyretin ligands through adjustable linkers to increase serum half-life

Identity authentication by using human biological characteristic

A human biological characteristic file corresponding to a particular identity is received and used as a base file. A characteristic code to be authenticated is obtained according to a human biological characteristic of a person who requests identity authentication when an identity authentication request corresponding to the particular identity is received. A base characteristic code is collected from a base file. A collecting algorithm applied for collecting the base characteristic code is the same as or matches an algorithm applied for obtaining the characteristic code. The present techniques determine whether the base characteristic code and the characteristic code correspond to a same human biological characteristic. If a result is positive, the identity authentication request is verified. The present techniques implement communication between different terminal devices of different manufacturers and effectively improve user experiences, thereby efficiently and conveniently implementing remote identity authentication.

Conjugation of pharmaceutically active agents with transthyretin ligands through adjustable linkers to increase serum half-life

A delivery system for active agents, and methods of making and using the systems, are provided. The delivery systems have (i) a ligand that is selective for an endogeneous plasma protein in the serum of a subject; and, (ii) a linker configured for operatively attaching the ligand covalently to an active agent to increase the half-life of the active agent in the serum.

System and method for intelligent circuit breaking in adjustable speed drives

CHOLESTERIC REGULATING COMPLEX OF SIRT1 AND LXR AND ITS USE

Ocular Agent Delivery Systems

This invention is directed to novel ocular agent delivery systems and, in particular, emulsions and molecular dispersions in the form of a gel comprising a hydrophobic ocular agent.

Delayed sustained-release oral drug dosage forms of a janus kinase (jak) inhibitor and methods of use thereof

Provided are delayed sustained-release oral drug dosage forms comprising a Janus kinase (JAK) inhibitor, such as tofacitinib. In other aspects, provided are methods of designing, methods of making, such as using three-dimensional printing, and methods of treatment and/or prevention associated with the oral drug dosage forms described herein.

Multi-chamber tire manufacturing mold

Un molde (1) de fabricación de neumáticos multicámara que comprende una placa superior (11) de sujeción y una placa inferior (12) de sujeción; la placa superior (11) de sujeción y la placa inferior (12) de sujeción están dispuestas alternativamente y en paralelo entre sí con intervalos entre la placa superior (11) de sujeción y la placa inferior (12) de sujeción; una pluralidad de deslizadores (16) que forman la periferia del neumático, bloques (121) del molde superior, bloques (122) del molde inferior y postes centrales (18) de molde están dispuestos en los intervalos; los deslizadores (16) que forman la periferia del neumático están dispuestos a lo largo de la dirección de altura de los intervalos, y la pluralidad de deslizadores (16) que forman la periferia del neumático están conectados en orden y dispuestos de forma anular; los postes centrales (18) del molde están dispuestos a lo largo de la dirección de la altura de los intervalos de manera anular, y ubicados en un lado interno de la pluralidad de deslizadores (16) que forman la periferia del neumático, y dispuestos alternativamente con la pluralidad de deslizadores (16) que forman la periferia del neumático; el poste central (18) del molde está configurado en el interior con una parte (19) de formación que está dispuesta alrededor del poste central (18) del molde; un extremo inferior de la placa superior (11) de sujeción está conectado con una pluralidad de bloques (121) del molde superior que están dispuestos en un círculo; se forma una cámara cerrada entre la pluralidad de bloques (121) del molde superior, la pluralidad de bloques (122) del molde inferior, las partes (19) de formación y la pluralidad de deslizadores (16) que forman la periferia del neumático; la cámara está provista en su interior con una pluralidad de deslizadores (17) que forman la cámara interna del neumático, que están conectados en orden dispuestos alrededor de la cámara; el deslizador (17) que forma la cámara interior del neumático ...

High-precision additive manufacturing device and high-throughput additive manufacturing system

The present disclosure generally relates to an additive manufacturing system. The system can comprise a material supply module for melting and pressurizing a printing material; a micro-screw printing head comprising: a micro-screw comprising a threaded stem portion and a conical head portion, wherein the threaded stem portion is threaded throughout its length for volume measurement; a sleeve, and a nozzle, wherein a distal end of the nozzle comprises: a conical inner surface, and an outlet port for dispensing the print material, wherein the conical inner surface of the nozzle is configured to be in contact with the conical head portion of the micro-screw to stop dispensing the printing material at the nozzle when the micro-screw printing head is in a closed position; a driving module comprising: a rotation motor for driving a rotating motion of the micro-screw, and an actuator for driving a vertical motion of the micro-screw.

Light-transmissive display panel, display panel and display apparatus

The present application provides a light-transmitting display panel, display panel and display apparatus. The light-transmitting display panel includes a first pixel array including a first minimum repeating unit. The first minimum repeating unit includes at least one light-transmitting column unit. The at least one light-transmitting column unit has a central axis parallel to an extending direction of the at least one light-transmitting column unit. The at least one light-transmitting column unit includes a plurality of first sub-pixels spaced apart from one another in the extending direction of the at least one light-transmitting column unit, wherein at least one of the first sub-pixels in the at least one light-transmitting column unit is set to deviate from the central axis. According to the light-transmitting display panel of embodiments of the present application, photosensitive components may be integrated on the back of the light-transmitting display panel, to achieve under-screen integration of the photosensitive components such as cameras, while the light-transmitting display panel can display pictures, so as to achieve a full-screen design in which the light-transmitting display panel is applied to a display apparatus.

System and method for intelligent circuit breaking in adjustable speed drives

An ASD circuit includes an input, solid-state switch rectifier bridge, DC link, and DC link capacitor bank. A pre-charge circuit is coupled between the input and the DC link capacitor bank and includes pre-charge relays operable in an on state that allows the AC power input to power the rectifier bridge during a normal operating state and an off state that allows the AC power input to pre-charge the DC link capacitor bank through a pre- charge resistor of the pre-charge circuit during a pre-charge operating state. A protection relay of a protection circuit is coupled between the pre-charge relays and the DC link capacitor bank, the protection relay operable in an on state that prevents the pre-charge circuit from connecting to the DC link capacitor bank when a capacitor short circuit occurs and an off state that allows the pre-charge circuit to electrically connect to the DC link capacitor bank.

一种工程管理咨询用演示装置

本实用新型公开了一种工程管理咨询用演示装置，包括底座，万向轮，主面板所述底座的内腔两侧均设置有螺纹杆，所述螺纹杆的顶部贯穿底座的顶部内表壁并延伸至外部，所述螺纹杆的底部套接有副锥齿，所述底座的底部内表壁通过螺栓固定安装有双轴驱动电机，所述双轴驱动电机的输出轴均套接有主锥齿，所述主面板的后端面设置有螺纹块。本实用新型中，通过双轴驱动电机、螺纹杆、螺纹块的设置，利用驱动电机带动螺纹杆旋转，螺纹杆转动的同时使套设在螺纹杆外的螺纹块上下移动，从而带动主面板上下运动，实现了主面板的高度调节。

Methods of designing an oral drug dosage form based on a target pk profile and dosage forms thereof

Method and system for creating pharamceutical products by additive manufacturing

Provided are pharmaceutical products manufactured using additive manufacturing technology. An exemplary printing system comprises: a material supply module for receiving a set of printing materials; a flow distribution module comprising a flow distribution plate, wherein the material supply module is configured to transport a single flow corresponding to the set of printing materials to the flow distribution plate; wherein the flow distribution plate comprises a plurality of channels for dividing the single flow into a plurality of flows; a plurality of nozzles, wherein the plurality of nozzles comprises a plurality of needle-valve mechanisms; one or more controllers for controlling the plurality of needle-valve mechanisms to dispense the plurality of flows based on a plurality of nozzle-specific parameters; and a printing platform configured to receive the dispensed plurality of flows, wherein the printing platform is configured to move to form a batch of the pharmaceutical product.

Shoe sole

Display panel

A display panel includes a first display region with multiple light-transmitting sub-pixels and multiple non-light-transmitting sub-pixels. The multiple light-transmitting sub-pixels and the multiple non-light-transmitting sub-pixels are arranged in a preset pixel arrangement structure in the first display region. The multiple non-light-transmitting sub-pixels are randomly arranged in at least one set region of the first display region.

Method and system for creating pharamceutical products by additive manufacturing

Cholesterinregulierender komplex aus sirt1 und lxr und seine verwendung

Gastroretentive pharmaceutical dosage form

A pharmaceutical dosage form, comprising: a pharmaceutical unit which includes a drug, at least one unfolding member, and a retaining member, wherein the unfolding member is connected to the pharmaceutical unit, and is constructed to have a contracted shape, which makes the unfolding member become closer the pharmaceutical unit, and an unfolding shape, which makes the unfolding member become farther away from the pharmaceutical unit; the retaining member is connected to the at least one unfolding member, and applies a constraint force to the at least one unfolding member, so as to make the unfolding member be in the contracted shape; and the retaining member contains a water-soluble material, and is constructed to remove the constraint force from the unfolding member when the water-soluble material is dissolved, such that the at least one unfolding member can change from the contracted shape to the unfolding shape.

Methods of designing an oral drug dosage form based on a target pk profile and dosage forms thereof

Drug dosage forms for stomach retention

Provided herein are drug dosage forms having a swellable component, which alone or in conjugation with one or more other components of the drug dosage forms expand the overall size of the drug dosage form in the stomach. The drug dosage forms are configured to be retained in the stomach for an extended period of time based on this increase in size of the drug dosage form in the stomach (e.g., retained in the stomach for a period of at least about 24 hours). The drug dosage forms described herein are formulated to release a drug during at least a portion of the stomach residency period. In other aspects, also provided are methods of designing, methods of making, such as using three-dimensional printing, and methods of delivering a drug to an individual, wherein such methods are associated with the drug dosage forms described herein.

Dosage forms with desired release profiles and methods of designing and making thereof

In some aspects, the present disclosure provides dosage forms, such as oral drug dosage forms, configured to provide a desired release profile, the dosage forms comprising a multi-layered structure comprising a plurality of layers of a first erodible material admixed with a compound (e. g., a drug) or a reagent, wherein the first erodible material is embedded in a second material not admixed with the compound (e. g., the drug) or the reagent. In other aspects, the present disclosure provides methods of designing, such as obtaining a thickness and/or surface area of a layer comprising an erodible material admixed with a compound (e. g., a drug) or a reagent, and/or amount of the compound (e. g., the drug) or the reagent admixed in the erodible material, and methods of making, such as three-dimensional printing, dosage forms configured to provide desired release profiles.

Oral drug dosage forms having a desired pk profile and methods of designing and producing thereof

Dosage forms with desired release profiles and methods of designing and making thereof

In some aspects, the present disclosure provides dosage forms, such as oral drug dosage forms, configured to provide a desired release profile, the dosage forms comprising a multi-layered structure comprising a plurality of layers of a first erodible material admixed with a compound (e. g., a drug) or a reagent, wherein the first erodible material is embedded in a second material not admixed with the compound (e. g., the drug) or the reagent. In other aspects, the present disclosure provides methods of designing, such as obtaining a thickness and/or surface area of a layer comprising an erodible material admixed with a compound (e. g., a drug) or a reagent, and/or amount of the compound (e. g., the drug) or the reagent admixed in the erodible material, and methods of making, such as three-dimensional printing, dosage forms configured to provide desired release profiles.

Dosage forms with desired release profiles and methods of designing and making thereof

Dosage forms of controlled release at specific gastrointestinal sites

A dosage form of controlled release at specific gastrointestinal sites is provided. The dosage form includes a shell defining a first and a second compartment, a first active phamaecutical ingredient (API) loaded in the first compartment, and a second API loaded in the second compartment, wherein the first API and the second API can be the same or different. The shell includes a first material soluble in a first gastrointestinal site and a second material soluble in a second gastrointestinal site.

Fremgangsmåde og systemer til frembringelse af farmaceutiske produkter gennem fremstilling af tilsætningsstof

Delayed sustained-release oral drug dosage forms of a janus kinase (jak) inhibitor and methods of use

Provided are delayed sustained-release oral drug dosage forms comprising a Janus kinase (JAK) inhibitor, such as tofacitinib. In other aspects, provided are methods of designing, methods of making, such as using three-dimensional printing, and methods of treatment and/or prevention associated with the oral drug dosage forms described herein.

Oral drug dosage forms for stomach retention

Provided herein are drug dosage forms designed to provide a desired retention in an individual based on geometric differences between a pre-administration and post-administration state of the dosage form. In certain aspects, provided are oral drug dosage forms comprising a swellable and expandable material configured, upon swelling or expanding, to drive expansion of the overall size of the oral drug dosage forms such that the oral drug dosage forms are retained in the stomach for a desired period of time. In certain other aspects, provided is directed to components useful for the oral drug dosage forms taught herein. In certain other aspects, provided is directed to methods of designing, methods of making, such as involving three-dimensional (3D) printing, injection molding, ultrasonic welding, or any combination thereof, commercial batches, and methods of delivering a drug to an individual comprising administering an oral drug dosage form taught herein.

一种纤维与沥青材料粘结强度测试装置

本实用新型公开了一种纤维与沥青材料粘结强度测试装置，包括试件制备部分和拉伸测试部分；试件制备部分包括支架、底座和沥青基槽，沥青基槽的轴心处开设有中心孔，纤维穿过中心孔伸入底座的空腔中，纤维的上端设置固定件，下端设置一配重件；拉伸测试部分包括万能试验机和盛样皿，纤维穿过盛样皿的开孔。本实用新型的有益效果是，测试装置结构简单，便于制作与操作，试件制作精度高；通过拉拔试验可测出不同纤维与沥青胶浆间的粘结强度，便于找出与沥青粘结效果最好的纤维；从纤维与沥青基体的粘结性能的角度出发，通过测定纤维与沥青胶浆的粘结强度实现了对路用纤维的评价和选型。

Cancer detection model and construction method therefor, and reagent kit

A cancer detection model and a construction method therefor, and a reagent kit, relating to the technical field of cancer detection. The method comprises: performing whole genome sequencing on plasma free DNA to mine nucleosome distribution features, terminal sequence features, and fragment size distribution features that can be applied to cancer detection; constructing classification models of the three indicators to obtain prediction scores of each indicator for a sample; then integrating these scores using a logistic regression model, and adding copy number variation feature information to obtain an ultimate classification and prediction model. The cancer detection model significantly improves the efficiency and accuracy of cancer detection, requires a small amount of data for analysis, has low detection cost, can detect different cancers, and is applicable for analyzing and predicting tumors in various stages. In addition, the reagent kit can complete the detection of the indicators required by the detection model, such that the reagent kit can be innovatively applied in ctDNA detection in the field of cancers.

Display panel, display apparatus, and display panel forming method

The present application relates to a display panel, a display device and a forming method of the display panel. The display panel includes a first region, and the display panel includes: a substrate; a light-emitting device layer stacked on the substrate, wherein the light-emitting device layer includes a plurality of first light-emitting devices distributed in an array in the first region, and wherein the first light-emitting device includes a first electrode, a particle unit disposed at least partially in a same layer with the first electrode and surrounding the first electrode, a first light-emitting module located on the first electrode, and a second electrode located on the first light-emitting module; wherein the particle unit includes a glue layer and a plurality of particles distributed within the glue layer, an orthographic projection of at least part of one particle of at least part of the particles on the substrate does not completely overlap with an orthographic projection of the first electrode on the substrate. The display panel provided by the present application can meet the requirements for full screen display, while reducing the impact of the diffraction phenomenon on the imaging effect of the devices such as front cameras.

Display panel, display apparatus, and display panel forming method

Display panel, display device, and forming method of display panel

A display panel, a display device and a forming method of the display panel. The display panel includes a first region, and the display panel includes: a substrate; a light-emitting device layer stacked on the substrate. The light-emitting device layer includes a plurality of first light-emitting devices distributed in an array in the first region, and the first light-emitting device includes a first electrode, a particle unit disposed at least partially in a same layer with the first electrode and surrounding the first electrode, a first light-emitting module located on the first electrode, and a second electrode located on the first light-emitting module. The particle unit includes a glue layer and a plurality of particles distributed within the glue layer.

Delayed sustained-release oral drug dosage forms of a janus kinase (jak) inhibitor and methods of use thereof

Provided are delayed sustained-release oral drug dosage forms comprising a Janus kinase (JAK) inhibitor, such as tofacitinib. In other aspects, provided are methods of designing, methods of making, such as using three-dimensional printing, and methods of treatment and/or prevention associated with the oral drug dosage forms described herein.