18-04-2023 дата публикации
Номер: CN115974891A
Принадлежит:
The invention provides a preparation method of norcantharidin, and relates to the technical field of organic synthesis. The preparation method comprises the following steps: mixing dehydrogenated norcantharidin, 2, 6-dimethyl-1, 4-dihydro-3, 5-dipyridinedicarboxylic acid diethyl ester, an organic solvent and a palladium carbon catalyst, and carrying out hydrogenation reduction reaction in a protective atmosphere to obtain the norcantharidin, the hydrogenation reduction reaction is carried out under a normal pressure condition. According to the method, 2, 6-dimethyl-1, 4-dihydro-3, 5-dipicolinic acid diethyl ester is used as a hydrogen source for catalytic hydrogenation reduction of the dehydrogenated norcantharidin, and the norcantharidin can be prepared through normal-pressure hydrogenation reduction. According to the invention, 2, 6-dimethyl-1, 4-dihydro-3, 5-dipicolinic acid diethyl ester is adopted to replace hydrogen, a more stable hydrogen source is adopted, the reaction is carried ...
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