Full rhizoma gastrodiae tablet

Technical Field

The invention belongs to the technical field, in particular, relates to a kind of treating stroke sequelae of numbness of the, dizziness, headache type throughout the day.

Background Art

In stroke also is called the brain stroke, is the traditional Chinese medicine collectively as acute brain blood vessel disease. Is a sudden blood circulation pepperment of the brain. Refer to patients with diseases of the blood vessel in the brain, inducing factors cause the narrow artery in the brain, occlusion or rupture, and to cause acute brain blood circulation disorders, used for a clinical manifestations or symptoms of dysfunction permanent brain and sign, is to deliver blood to the brain caused by vascular disease of a kind of acute diseases. In the brain caused by wind will be sudden damage to the brain tissue, usually occurs in oxygen to the brain and other nutrients burst of the blood vessel, or the vessel the blood clot or other particulate matter is blocked. If nerve cells lack of adequate oxygen supply, will die in a few minutes. Furthermore, the control of these nerve cells by bodily functions will be thereupon is out of action. The cell is unable to replace the death of the brain, the consequences of the wind in the brain is usually permanent. 2012 years, 3rd National inquest display, cerebral apoplexy ranking rate of 1st, as high as 22.45%.

The importance of prevention of stroke to the attention of the medical community at home and abroad has been caused, the numbness caused by stroke, pain, hemiplegia, hemiparalysis, and the like, a serious impact on the physical and mental health of the patient, therefore, the treatment of numbness caused by stroke, pain, hemiplegia, hemiparalysis of the present improvement is that there is an urgent need to solve the problem.

"Shennong the book on Chinese medicine passes through " contained in elevated gastrodia beginning , taste Gan Xingping , into the liver meridian, the invention also discloses, gels proclaims rheumatism , analgesic effects such as excellent. Pharmacological research confirmed after generation : gastrodia the viscosity of the blood can be reduced, accelerating the velocity of red blood cells, platelet aggregation function improvement, cerebrovascular system so as to improve the blood supply. Chinese medicine, numbness caused by stroke, vertigos, by such as the kidney deficiency, comprises, nourishing the liver wooden loses , the function type. For treating such arthromyodynia gastrodia to give a plurality of pharmaceutical,

Due to the unilateral preparation of limited effectiveness, in particular, some human body for the limitation of the capabilities of its potency, therefore, simply administer gastrodia, effect sometimes is not obvious; at this time, often the patient will mix with the taking of the western medicines for the treatment of such drugs, the side effects of western medicine is relatively large, in this case but also influences the function of a normal human body.

Content of the invention

The purpose of this invention is to provide a entire elevated gastrodia piece for treating cerebral apoplexy sequelae, for treating diseases with has been the core of the traditional Chinese medicine theory, against major pathomechanisms medicine for how both secondary pathomechanisms, the treatment of both common and individual characteristics, the maximum degree to reflect the contents of the Chinese medicine for treating diseases with the epitaxial, is a practical problem of compatibility. [...]wind stasis to the applicant in the brain, characterized in the pathogenesis of the winds damages the hematorrhea , combine a large amount of their predecessors and pass to the number of prescriptions of traditional Chinese medicine research, and combines the dialectic demonstration, long various multi-collection, the search for the best treatment programme, from the motherland in medical treasure, screening the cool blood open silt, the natural Chinese medicine, according to the Chinese medicine theory, extracting essence, combination of technical carefully formulating the cost of traditional Chinese medicine for of the invention the traditional Chinese medicine preparation of cerebral apoplexy, with respect to the western medicine, fast onset of traditional Chinese medicine of the present invention, effect, short course of treatment, the safety is high, no obvious toxic side effects. All medicines, each other, play cool the blood open silt, the efficacy of the, improved Craniocerebral microcirculation, protecting brain tissues, effectively blocking secondum pathological damage.

To achieve the purpose of this invention, the technical proposal adopted by this invention are as follows:

For brain stroke sequelae entire elevated gastrodia piece , the preparation method is as follows:

takes the elevated gastrodia 500g drying, crushed into fine powder that is, a 100 mesh sieve, adding microcrystalline cellulose 20g, powdered sugar 50g, low-substituted hydroxypropyl cellulose 10g, mixing, with 10% ethanol granulation, drying, by adding magnesium stearate 5.8g, mixing, is pressed into a 1000 sheet, packet thin film coating, is obtained.

Preferably, this invention has offered a kind of the used for treating brain apoplexia sequela entire elevated gastrodia piece , which is composed of the following weight proportion, and the raw material preparation:

Gastrodia 500 parts, Radix Angelicae Sinensis 50 parts, grassleaved sweetflag 30 parts, Pinelliae Preparatum 30 parts, radix Astragali 30 parts,

Semen Persicae (peach seed) 25 parts, senega 25 parts, callitriche 25 parts, Radix Salviae Miltiorrhizae 25 parts, Chinese scholartree 25 parts,

Perilla leaves 20 parts, monascin 20 parts, polyrorus 20 parts, gynostemma pentaphylla 20 parts, Panax notoginseng 20 parts,

Rhizoma Chuanxiong 15 parts, frankincense 15 parts, Herba Taraxaci (taraxacum, dandelion) 15 parts, aucklandiae 15 parts, white venenosum 15 parts,

Ppfa 10 parts, Hohuan piney 10 parts;

The preparation method is as follows: according to the above-mentioned weight of the weighed raw materials

(1) taking gastrodia, senega, callitriche, Radix Salviae Miltiorrhizae, aucklandiae, white venenosum, ground through 100 mesh sieve, to obtain powder;

(2) test (in other words Radix Angelicae Sinensis 50 parts, grassleaved sweetflag 30 parts, Pinelliae Preparatum 30 parts, radix Astragali 30 parts, Semen Persicae (peach seed) 25 parts, Chinese scholartree 25 parts, perilla leaves 20 parts, monascin 20 parts, polyrorus 20 parts, gynostemma pentaphylla 20 parts, Panax notoginseng 20 parts, Rhizoma Chuanxiong 15 parts, frankincense 15 parts, Herba Taraxaci (taraxacum, dandelion) 15 parts, ppfa 10 parts, Hohuan piney 10 parts) add raw materials 5 times of water 30 minutes later, boiling by high heat, decocting 30 minutes, cooling, filtering and gruffs the filtrate obtained after;

(3) step (2) add gruffs obtained in 3 times of water boiling, boiling by high heat, decocting 30 minutes, cooling, and the filtrate from the filtration residue;

(4) the merging step (2) and step (3) two concentrating the filtrate into density is 1.1-1.2g/ml the plaster, for the 50-60 after drying [...] , pulverize 100-120 purpose powder;

(5) hybrid (1) and step (4) the obtained powder, conventional granulation to obtain.

Method of use: an oral time 3-6 pieces, three times a day, each piece of heavy 0.6g;

The component of the medicament of the invention are made of natural raw materials of traditional Chinese medicine, its preparation is simple and convenient, the medicine source is extensive, low cost, its follow the principle of prescription of Chinese medicine, all medicines, each other, small dosage of the preparation of the invention, the pharmaceutical active ingredient is easy to release, rapid absorption, bioavailability is high, can give full play to the drug, the clinical application verifies, its curative effect is prominent and reliable, is gentle, no toxic side effects, application prospect.

Mode of execution

Embodiment 1

For brain stroke sequelae entire elevated gastrodia piece , the preparation method is as follows:

takes the elevated gastrodia 500g drying, crushed into fine powder that is, a 100 mesh sieve, adding microcrystalline cellulose 20g, powdered sugar 50g, low-substituted hydroxypropyl cellulose 10g, mixing, with 10% ethanol granulation, drying, by adding magnesium stearate 5.8g, mixing, is pressed into a 1000 sheet, packet thin film coating, is obtained.

Method of use: an oral time 3-6 pieces, three times a day, each piece of heavy 0.6g;

Embodiment 2

For brain stroke sequelae entire elevated gastrodia piece , which is composed of the following weight proportion, and the raw material preparation:

Gastrodia 500 parts, Radix Angelicae Sinensis 50 parts, grassleaved sweetflag 30 parts, Pinelliae Preparatum 30 parts, radix Astragali 30 parts,

Semen Persicae (peach seed) 25 parts, senega 25 parts, callitriche 25 parts, Radix Salviae Miltiorrhizae 25 parts, Chinese scholartree 25 parts,

Perilla leaves 20 parts, monascin 20 parts, polyrorus 20 parts, gynostemma pentaphylla 20 parts, Panax notoginseng 20 parts,

Rhizoma Chuanxiong 15 parts, frankincense 15 parts, Herba Taraxaci (taraxacum, dandelion) 15 parts, aucklandiae 15 parts, white venenosum 15 parts,

Ppfa 10 parts, Hohuan piney 10 parts;

The preparation method is as follows: according to the above-mentioned weight of the weighed raw materials

(1) taking gastrodia, senega, callitriche, Radix Salviae Miltiorrhizae, aucklandiae, white venenosum, ground through 100 mesh sieve, to obtain powder;

(2) test (in other words Radix Angelicae Sinensis 50 parts, grassleaved sweetflag 30 parts, Pinelliae Preparatum 30 parts, radix Astragali 30 parts, Semen Persicae (peach seed) 25 parts, Chinese scholartree 25 parts, perilla leaves 20 parts, monascin 20 parts, polyrorus 20 parts, gynostemma pentaphylla 20 parts, Panax notoginseng 20 parts, Rhizoma Chuanxiong 15 parts, frankincense 15 parts, Herba Taraxaci (taraxacum, dandelion) 15 parts, ppfa 10 parts, Hohuan piney 10 parts) add raw materials 5 times of water 30 minutes later, boiling by high heat, decocting 30 minutes, cooling, filtering and gruffs the filtrate obtained after;

(3) step (2) add gruffs obtained in 3 times of water boiling, boiling by high heat, decocting 30 minutes, cooling, and the filtrate from the filtration residue;

(4) the merging step (2) and step (3) two concentrating the filtrate into density is 1.2g/ml the plaster, for the 60 after drying [...] , is pulverized to 120 purpose powder;

(5) hybrid (1) and step (4) the obtained powder, conventional granulation to obtain.

Method of use: an oral time 3-6 pieces, three times a day, each piece of heavy 0.6g;

Embodiment 3

Zoology experiment

Health kunming strain mouse 40 only, the male half, weight to be 18.5 ±2 . 0g, will 40 only mouse random are divided into two groups, each of female half, wherein the 20 only as a control group, filling with water; in addition, 20 to the mouse embodiment of only 2 drug, application mouse acute toxicity experiment shows that: compares the control group, MICE after administration not see obvious difference, two week experimental continuous observation, mouse systemic situation, eating, drinking water, weight growth are normal. Administration on the same day and within two weeks after administration, not see animal death, prompt arimoclomol acute toxicity is low, safe clinical application.

Long term toxicity test

SD RAT is 40 only, the male half. According to the body weight random divided into 2 groups, that is, the control group (to give equivalent distilled water), traditional Chinese medicine composition of the invention. Each group of 20 only, the male half. Each group of animals every day to perfuse, continuous dosing 1 month later, are respectively the universal experimental group, the control group 10 only; convalescent (drug 2 weeks) are respectively the universal experimental group, compared with the 10 only. The appearance of the observe the animal during test period, the general behavior, body weight changes, setsu appetite, water intake, after administration 1 months and discontinuance 2 weeks (convalescent) for haematologica, serum biochemical, zoki coefficient and histopathological indicators inspection. Test results show that: each group of animals in good condition in general, the appearance of the sign, conduct activities, no abnormal change in body weight;

Embodiment 4

Clinical cases

A total of observed cases cases information 105 example, the patient to the hospital's outpatient and the patient brain illness branch , random shan Mang is divided into embodiment 1 group, embodiment 2 group, the control group 3 group, each group 35 example. Wherein the male 56 example, female 49 example, age 45-75-year-old, average 63.7 years of age, course of disease 7 days to 6 months, the average 1.5 months; wherein one side of the upper limb parasthesia 33 example, one side leg numbness 45 example, upper and lower limbs are numb two sides 27 example; two groups of the gender, age, course of disease, the extent and the accompanied by serious condition, such as disease, no significant difference   (P > 0.05), comparability.

Western medicine diagnostic standards of the National standards on the diagnosis of cerebral meetings 4th session diagnostic standard, and a consequential apoplexy leaning body limb numbness, accompanied by chills, heating, the cold sweat, such as performance creepsing damaged neural function. In traditional Chinese medicine diagnosis   1996   years state administration of traditional Chinese medicine encepalopathy acute cooperative diagnosis standard apoplexia of traditional Chinese medicine. Medicine which belongs to the deficiency of blood stasis, medicinal patient pain. The numbness of skin, or companion hypoalgesia, the four limbs sleepy heavy , the bow heavy like binds , do not want to diet, tongue fat liver moss Bai Ni , slow the arteries slide ; or skin numbness, listlessness, with less the surface is white , the tongue substance is pale with petechia, liver moss thin white , or the string is astringent antidiabetic sulfonylurea.

Methods of treatment

Control group: to conventional western medicine for treating, including brain protection, improving cerebral circulation, nutrition nerve, etc., accompanied with hypertension, diabetes, coronary heart patients to depressurization, processing such as control blood sugar and dilating coronary artery. Ischemic apoplex adds anti- platelet aggregation, anticoagulant therapy.

Embodiment 1 group of: adding in the control group on the basis of the embodiment 1 preparation of full gastrodia pharmaceutical preparation, a 3-6 pieces, three times a day, each piece of heavy 0.6g;

Embodiment 2 group of: adding in the control group on the basis of embodiment 2 preparation of full gastrodia pharmaceutical preparation, a 3-6 pieces, three times a day, each piece of heavy 0.6g;

For the 4 week (a course of treatment)

Observing the indicators and statistical method

Observation indicators

Indicators health giving quality subjective symptoms of the patient, including numbness, pain or the like, before and after treatment the symptoms of the patients judges whether the one-time.

General physical examination item safety indicators (body temperature, blood pressure, respiration, pulse), conventional hematuria excrement , kidneys function inspection, and the like, for more than for item of the clinical study before and after the end of a previous check, adverse reactions observed at any time.

All data are the statistical method SPSS10.0 software processing, the inspection t metering information, the count information χ 2 test, for testing Ridit grade information.

Curative effect standards and treatment results

Standard curative effect: standard curative effect:   reference state administration of traditional Chinese medicine   1995   promulgated in "effect of traditional Chinese medicine diagnostic disease standard" determining. Cure: all the feel   numb and accompanying abnormal symptoms completely disappeared, the examination is not felt obstacles; effective: symptoms of   numbness, improving or alleviating symptoms of, whose main symptom is still induce emotional or fast not affect life; void: no change in   numbness symptoms, symptoms of improvement or improved.

With two groups of patients, see table   1

   Safety indicators before and after treatment the clinical observation 3 group of patient's general physical examination item, hematuria excrement routine inspection, inspection of cardiac function has no obvious changes, and the like. Observation period, 3 during the clinical observation in no serious adverse events.  T the   test, three sets of before and after treatment related indicators routine blood test liver and kidney function and there is no significant difference, P > 0.05, prompting the two groups during administration to the liver and kidney function and hemograms have not obviously affected. And embodiment 2 group of the cure rate is and always with significant difference obviously rise in efficiency.

Embodiment 5

Typical cases

Case 1: whom, male, 66 years of age. 4 years ago, arises suddenly the brain stroke, although the timely rescue, but still leave the serious side-effects. Numb limbs, limb movement obstacles to the left side, upper right limb lift limited, cannot be foot to the hands, a sweating, sleep is poor. Diagnostic: stroke sequale; time: tranquilizing and, the evil. To give example 2 preparation of pharmaceutical compositions for the treatment of stroke sequelae 1 of treatment (after all around), a marked improvement in patient limb activities, nano food to best, sleeps peacefully. Taking enjoins to continue 1 of treatment, a patient to move freely, fully cured, have no recurrence to follow up.

Cases 2, Xie, female, 71-year-old. 1 years ago after the left side of the left after the hemiparalysis stroke, limb numbness, western medicines for the treatment of the no effect, acupuncture a month is not the effect. Pain often edema of adjusting, can not walk and, liver moss Bai Ni , several the arteries slide. Diagnostic: stroke sequelae. Treatment method: yin the spleen, stasis, to embodiment 2 preparation of the pharmaceutical composition, 2 weeks, adjusting and pain symptoms significantly reducing edema, the condition obviously improved. Continue taking to a course of treatment, enhanced somatogen, strong limbs, the examination is not felt obstacles, the acroanesthesia coats, curing, have no recurrence to follow up.

Only enumerated above is the best embodiment of the invention. Obviously, the invention is not limited to the above embodiment, there can also be many deformation. The ordinary technical personnel in this field from the content disclosed in this invention or directly derived Lenovo all the deformation, should be considered to be the protection range of this invention.