Fluorescent probe for detecting heparin content in blood as well as synthetic method and application

The invention relates to a high-selectivity and high-sensitivity fluorescent probe fordetecting heparin, particularly detecting the heparin content in blood as well as a synthetic method and application. The synthetic method comprises the following steps of: dissolving tertiary amine with substituent groups R1, R2 and R3 or tertiary diamine with the substituent groups R1, R2, R3 and R4 into an organic solvent, and adding halogenated alkyl aromatic, wherein the mol ratio of the halogenated alkyl aromatic to the tertiary amine with the substituent groups R1, R2 and R3 or the tertiary diamine with the substituent groups R1, R2, R3 and R4 is 0.01-50; reacting for 0.5-60 hours at the reaction temperature of 30-100 DEG C, and obtaining a compound with an (A) structure or a (B) structure by utilizing silica gel column chromatography after solution concentration. The fluorescent probe has good selectivity for the heparin, has no toxic or side effect per se, can reach the detection limit for the ...

Chitosan oligosaccharide sulphate and preparation method thereof