10-06-2021 дата публикации
Номер: US20210169896A1
Автор:
BAI Lu,
CAO Mingjun,
GAI Shun,
GUO Huihui,
GUO Zhixiang,
Huang Yuanyuan,
JIA Junxiang,
LEI Jun,
Li Wenjun,
Xie Hongsheng,
YANG Chengyu,
YANG Qingliang,
YANG Yanlei,
YE Hangbo,
YE Zhicang,
ZHAO Linyao,
ZHAO Robert Yongxin,
Zheng Jun,
ZHOU Xiaomai,
ZHUO Xiaotao
Принадлежит:
The present invention relates to novel cross-linked cytotoxic agents, pyrrolobenzodiazepine dimer (PBD) derivatives, and their conjugates to a cell-binding molecule, a method for preparation of the conjugates and the therapeutic use of the conjugates. 12Bacillus anthracisCanis lupus familiarisE. coliE. coliEscherichia coliPseudomonas aeruginosa. The cross-linked PBD dimer derivative or its conjugate to a cell-binding molecule according to claim 1 , wherein the cell binding molecule is capable of targeting against a tumor cell claim 1 , a virus infected cell claim 1 , a microorganism infected cell claim 1 , a parasite infected cell claim 1 , an autoimmune disease cell claim 1 , an activated tumor cells claim 1 , a myeloid cell claim 1 , an activated T-cell claim 1 , an affecting B cell claim 1 , or a melanocyte claim 1 , or any cells expressing any one of the following antigens or receptors: CD1 claim 1 , CD1a claim 1 , CD1b claim 1 , CD1c claim 1 , CD1d claim 1 , CD1e claim 1 , CD2 claim 1 , CD3 claim 1 , CD3d claim 1 , CD3e claim 1 , CD3g claim 1 , CD4 claim 1 , CD5 claim 1 , CD6 claim 1 , CD7 claim 1 , CD8 claim 1 , CD8a claim 1 , CD8b claim 1 , CD9 claim 1 , CD10 claim 1 , CD11a claim 1 , CD11b claim 1 , CD11c claim 1 , CD11d claim 1 , CD12w claim 1 , CD14 claim 1 , CD15 claim 1 , CD16 claim 1 , CD16a claim 1 , CD16b claim 1 , CDw17 claim 1 , CD18 claim 1 , CD19 claim 1 , CD20 claim 1 , CD21 claim 1 , CD22 claim 1 , CD23 claim 1 , CD24 claim 1 , CD25 claim 1 , CD26 claim 1 , CD27 claim 1 , CD28 claim 1 , CD29 claim 1 , CD30 claim 1 , CD31 claim 1 , CD32 claim 1 , CD32a claim 1 , CD32b claim 1 , CD33 claim 1 , CD34 claim 1 , CD35 claim 1 , CD36 claim 1 , CD37 claim 1 , CD38 claim 1 , CD39 claim 1 , CD40 claim 1 , CD41 claim 1 , CD42 claim 1 , CD42a claim 1 , CD42b claim 1 , CD42c claim 1 , CD42d claim 1 , CD43 claim 1 , CD44 claim 1 , CD45 claim 1 , CD46 claim 1 , CD47 claim 1 , CD48 claim 1 , CD49b claim 1 , CD49c claim 1 , CD49c claim 1 , CD49d claim 1 , CD49f ...
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