Information processing method, device, and system

The present disclosure discloses an information processing method, device, and system. The method includes: creating, by a server when detecting a task creation request, an information processing task according to a resource used for information playback and a pre-determined amount of the resource; detecting a feature value of the information playback after acquiring the information processing task; adjusting, if the feature value of the information playback is less than or equal to a preset threshold, the number of times of information playback according to the pre-determined amount of the resource by using a first playback policy, to delay reaching the pre-determined amount of the resource, and generating a corresponding playback task according to the resource and the first playback policy; adjusting, if the feature value of the information playback is greater than the preset threshold, the number of times of information playback according to the pre-determined amount of the resource ...

Re-ordered error diffusion for fast implementation

A method, non-transitory computer readable medium, and apparatus for performing error diffusion are disclosed. For example, the method quantizes an error for a first pixel of a plurality of pixels in a first row, diffuses the error to an adjacent pixel of the plurality of pixels in the first row, performs the quantizing and the diffusing for each remaining pixel of the plurality of pixels in the first row and applies the error that is quantized for each one of the plurality of pixels the first row in a desired number of different directions in a plurality of parallel operations that is equal to the desired number of different directions.

Method and Apparatus for Implementing Animation in Client Application and Animation Script Framework

A method for implementing animation in a client application, includes receiving an animation code written in a script language from a server, the animation code including a logic script and an animation description script; parsing the logic script in the animation code, and obtaining a view identifier, an animation identifier, and a pre-obtained correspondence relationship between the view identifier and the animation identifier included therein; determining a view component to be driven and corresponding to the view identifier in a client application based on a correspondence relationship between view identifiers and view components, and reading an animation description to be implemented and corresponding to the animation identifier in the animation description script according to the animation identifier corresponding to the view identifier; and determining that loading of the animation description to be implemented in the view component to be driven according to a condition provided by the logic script.

Document classification using segmentation tag statistics

A first aspect of the of the present invention is a system and method for classifying an input document based a segmentation tag statistics. The method includes receiving first pass segmentation tags for a plurality of pixels within a block of image data; determining an image type for the block of image data using statistics compiled from the first pass segmentation tags; and generating rendering tags for pixels within the block of image data as function of second pass segmentation tags and the image type. Beneficially, the image type identified for the block of image data is used to optimize the rendering process.

Method and apparatus for identifying document size

A document size identification module receives a single scan of a document and detects for at least one of a black to white transition and a white to black transition. The black to white transition may represent a transition from an overscan area of a platen to a document. The white to black transition may represent a transition from the document to the overscan area of the platen. By detecting at least one of the black to white transition and the white to black transition, the document width may be determined. By determining the document width, the document size may be identified.

Reformatting Binary Image Data to Generate Smaller Compressed Image Data Size

In various exemplary embodiments, systems include a segmentor to segment text binary image data to a first plane. A subtractor subtracts text binary image from binary image data to generate a non-text binary image data in a second plane. A converter converts non-text binary image data in the second plane into non-text gray scale image data in the second plane. A first compressor compresses the text gray scale image data in the first plane. A second compressor compresses the non-text gray scale mage in the second plane.

Compression of mixed raster content (MRC) image data

In a mixed raster content (MRC) image data format, where a separation plane is used to define portions of the image to compressed in a lossy or lossless manner, edge pixels are identified in the separation plane. Each edge pixel is modified to assume a maximum luminance and most neutral chrominance found among neighboring pixels. The modification of the edge pixel data minimizes artifacts such as fringe effects when the image data is compressed and subsequently decompressed.

System and method for estimating continuous tone values from rendered binary input

A method and system for estimating continuous tone values associated with input pixels in a color image are provided. The method includes receiving binarized halftone image data representing a color image, wherein the color image has a plurality of input pixels; and estimating the continuous tone values associated with each of the input pixels by: establishing a window comprising a pixel of interest and neighboring pixels in the binarized halftone image data, wherein the window comprises a plurality of sub-window's and wherein each sub-window has a plurality of predetermined number of rows and columns of pixels; and processing the binarized halftone image data in both a process direction and a cross-process direction using the window such that the processing is performed for one of the pixels in each of the rows within the sub-window and the processing is skipped for the remaining pixels in that row of that sub-window.

ELECTRODE ASSEMBLY, BATTERY CELL, BATTERY, DEVICE, MANUFACTURING METHOD, AND MANUFACTURING DEVICE

An electrode assembly, a battery cell, a battery, a device, a manufacturing method, and a manufacturing device are provided. In some embodiments, the electrode assembly includes at least two electrode plates, including a first electrode plate and a second electrode plate that are of opposite polarities. The first electrode plate and the second electrode plate are wound around a winding axis to form a multilayer structure. The multilayer structure includes an accommodation cavity extending along a direction of the winding axis. The accommodation cavity is configured to accommodate an electrolytic solution. The electrode assembly further includes at least one guide path extending along a first direction. The first direction is a direction perpendicular to the winding axis. The guide path is configured to guide the electrolytic solution out of the accommodation cavity.

SECONDARY BATTERY, METHOD FOR PREPARING CORRESPONDING POSITIVE ELECTRODE ACTIVE MATERIAL, BATTERY MODULE, BATTERY PACK, AND ELECTRICAL APPARATUS

The present application relates to a secondary battery, comprising (1) a positive electrode plate; and (2) an electrolyte solution; wherein a positive electrode active material is an active material having a chemical formula of AxB1-xMeO2or AxB1-xMPO4with dications A and B, where Me, M, A, B, and x are as defined in the specification; and the electrolyte solution comprises an electrolyte salt of the dications A and B, where A and B are as defined in the positive electrode active material; as well as a method for preparing a corresponding positive electrode active material, a corresponding battery module, a battery pack, and an electrical apparatus. The secondary battery of the present application comprises a positive electrode active material comprising the dications A and B and an electrolyte solution of a salt of the same dications.

Hybrid image reduction method and apparatus with moir{acute over (e)} suppression

A method and apparatus for digital image reduction using an improved “extendible” perspective projection technique which allows for flexible control of the averaging cell or window size separately from the reduction ratio to improve moir{acute over (e)} suppression or sharpness as desired in the resulting reduced-size image. The extendible perspective projection technique can also be implemented together with ordinary perspective projection or together with a combined one-dimensional filter and linear interpolation technique to produce a reduced-size image of a quality comparable to those produced by the prior technique of using a two-dimensional pre-filter prior to interpolation at a much lesser cost due to the reduced number of required scanline buffers.

Ethereum state data storage optimization method, Ethereum system and storage medium

Disclosed are an Ethereum state data storage optimization method, an Ethereum state data storage optimization system, and an Ethereum system. The method includes: using an MPT tree structure to store Ethereum state data; and compressing a height of an MPT tree, so as to reduce the number of times of disk io. By increasing capacity of a branch node, optimization in a horizontal direction can be performed to the MPT tree of Ethereum state data; by compressing the height of the MPT tree of the Ethereum state data on a single prefix path, optimization in a vertical direction can be performed to the MPT tree of the Ethereum state data; and by selecting and arranging different key lengths according to a data type, layers of the MPT tree can be effectively reduced, so that the purpose of reducing the number of times of disk io can be achieved.

MAXIMIZING EFFICIENCY OF MULTI-USER COMMUNICATIONS NETWORKS

Systems and methods are described for jointly optimizing communications in a multi-user network to maximize the weighted sum-rate of its data links. For example, embodiments seek to maximize overall link transmit rates, while minimizing link interference and/or noise in general multi-in multi-out (MIMO) interference networks having multiple interfering data links, each with one or more antennas at the transmitter and receiver. Novel algorithmic approaches, including an iterative minimax approach and a dual link approach, are described for solving the weighted sum-rate maximization in a manner that converges quickly and reliably on an optimal point. Some embodiments implement these approaches in a centralized transmission controller, while others implement these approaches in a distributed fashion.

Methods and systems for estimating skew angle of an image

The disclosed embodiments illustrate methods and systems for estimating a skew angle of an image. The method includes identifying a set of measurable blocks from one or more blocks in said image. The method further includes dilating each measurable block, in said set of measurable blocks, with a predetermined regular structure to create a set of modified measurable blocks. The method further includes selecting a second set of measurable blocks from said set of modified measurable blocks based on a size of each modified measurable block in said set of modified measurable blocks. Thereafter, the method includes determining a slope of each measurable block in said second set of measurable blocks. Further, the slope is utilizable to estimate said skew angle of said image. The method is performed by one or more microprocessors.

Reformatting binary image data to generate smaller compressed image data size

In various exemplary embodiments, systems include a segmentor to segment text binary image data to a first plane. A subtractor subtracts text binary image from binary image data to generate a non-text binary image data in a second plane. A converter converts non-text binary image data in the second plane into non-text gray scale image data in the second plane. A first compressor compresses the text gray scale image data in the first plane. A second compressor compresses the non-text gray scale image in the second plane.

METHOD AND SYSTEM FOR ISOLATED DOT DETECTION AND GROWTH IN A DOCUMENT IMAGE

A method for detecting and growing isolated dots in a document image having a plurality of pixels is provided. The method includes isolating the pixels of the image to form a plurality of windows, each window having a target pixel; detecting an isolated dot in the received image; identifying a dot growth factor to grow the detected isolated dot in the received image; using the dot growth factor to identify tiered pixel patterns from a plurality of predefined, tiered pixel patterns, wherein each of the tiered pixel patterns having a predetermined dot growth factor; comparing the pixels within each window to the pixel patterns within the identified tier to identify a match between the pixels within the window and at least one of the pixel patterns; and changing a pixel value of the target pixel, when a match is identified, to grow the isolated dot by the dot growth factor.

Filter configuration for software based image path

A method, non-transitory computer readable medium and apparatus for generating an output image are disclosed. For example, the method includes receiving an image, applying a first filter, applying a second filter, calculating a difference between the image with the second filter that was applied and the image with the first filter that was applied and transmitting the difference to a sharpening module and a segmentation module to generate the output image.

Method and device for presenting release information

It is described a method and device for presenting release information. The method includes that: a total exposure of release information on a day is acquired in real time; and a current ratio for presenting release information is calculated according to the total exposure of release information on the day, and release information is presented according to the current ratio for presenting release information. With a technical solution as described, it is possible to distribute exposure of the release information reasonably according to a ratio for presenting adjusted in real time, allowing uniform and reasonable presenting of the release information.

TILE BASED COLOR SPACE TRANSFORMATION

A system and method for tile type based color space transformation improves the performance and image quality of multifunction devices. The disclosed embodiments transform an input image on a tile by tile basis. If a tile is detected as neutral, simple 1D L* to CMYK Tone Reproduction Curves or Look-Up-Tables are used to convert the input pixels of the tile in L*a*b* to output pixels in CMYK. If a tile is detected as containing color content, then the input pixels are chrominance adjusted and subsequently converted to CMYK using regular tetrahedral interpolation.

Methods and systems for adaptive stroke thickening of graphics objects

Methods and devices to improve the quality of graphics objects based on adaptive stroke thickening are disclosed. The method includes receiving a graphics object having at least one stroke. The graphics object is represented within an object window made of a plurality of cells. The method further includes identifying a fill region being defined by the stroke. Both the fill region and the stroke are represented by a group of cells. The identified fill region is tagged using a predefined flag indicating a tagged fill region or any its attributes. The stroke is strengthened unidirectionally away from the tagged fill region, where a stroke color associated with the stroke being strengthened is replaced by an adapted color provided the stroke color is same as a background color associated with a background, which is a part of the object window.

Binder compound, conductive binder, and secondary battery containing same

A binder compound, a conductive binder, and a secondary battery containing the same are provided. In some embodiments, the binder compound of the present disclosure has a structure of formula (I), where R1and R2each independently represent a straight or branched C1-12alkyl; R3represents a halogen or cyano group; R4represents a hydroxymethyl or amino; Z represents a straight or branched C1-12alkylene; and m represents an integer selected from 7600-47000. The binder compound and the conductive binder of the present disclosure can improve the storage and cycle performances of the secondary battery.

Method for setting random error parameter of fiber gyroscope simulated signal

The invention discloses a method for setting a random error parameter in the signal simulation process of a fiber gyroscope. The method is used for solving and setting a random error model parameter in signal simulation by utilizing the performance index of the fiber gyroscope. In the method, the performance index of the fiber gyroscope adopts angle random walk and zero bias stability. The random error model of the simulated signal adopts two schemes comprising a white noise and random walk superposed mode and a white noise and first-order Markoff process superposed mode. The fiber gyroscope signal simulated by the method can reflect the characteristics of the fiber gyroscope with certain precision grade well, and has high reliability and authenticity. The method is used for deducing and setting the random error model parameter in the simulation by utilizing the performance index of the fiber gyroscope, so that the performance of the simulated fiber gyroscope signal is fit with the preset ...

DOCUMENT BACKGROUND SUPPRESSION PERFORMED DURING COLOR SPACE CONVERSION

An electronic image in a first color space, used by image acquisition devices, is obtained and converted into a second color space with a larger gamut, to produce a second color space image. Corrections are made to the second color space image to produce a corrected image, without performing background suppression. The corrected image is converted into a third color space, used by printing devices, to produce a third color space image, and this process of converting the corrected image into the third color space includes performing background suppression. This process of converting the corrected image into the third color space samples nodes of the second color space values, classifies the nodes as background nodes or non-background nodes, multiplies the second color space values of the background nodes by a percentage less than 100%, and after multiplying, interpolates values between the nodes.

Method for image classification for copy path billing

Disclosed is a processor-implemented method for processing image data representing a document using an image processing apparatus. The processor receives image data, determines the classifications and counts of pixels in the image data (e.g., in device independent space that are degrees of neutral or non-neutral), classifies the image data into a category based on the determination of classifications and counts of pixels, and determines a billing structure for the image data based on the classification of image data. The classification can be performed on the image data prior to conversion into device dependent space. For example, by counting true color, neutral, non-neutral, and fuzzy color pixels and comparing them to thresholds, the image data can be classified as neutral or very colorful. By classifying images earlier in the image path, errors in billing are reduced.

SYSTEM AND METHOD FOR DETERMINING A BILLING STRATEGY FOR DOCUMENTS BASED ON COLOR ESTIMATIONS IN AN IMAGE PATH

Disclosed herein is a method and system for determining a billing structure for outputting documents using an image processing apparatus. If image data of the document includes color pixels, a billing structure is determined based on an estimated total color pixel count. The color pixels of the image data are counted in a device independent space and the total color pixel count of the image data to be output in a device dependent space is estimated. Based on the estimation, a billing structure is chosen. Processing and determining a billing structure based on image data in the device independent space avoids charging a customer for color print job when only a small amount of color pixels are printed. It also encourages determining charges independently of the marking engine or output device.

HEAT SOURCE-FREE FIBER POSITIONING AND ORIENTING SYSTEM FOR SEEPAGE OF SUBMERGED OR PARTIALLY-SUBMERGED STRUCTURES AND MONITORING METHOD THEREOF

A heat source-free fiber positioning and orienting system for seepage of submerged or partially submerged structures and monitoring method thereof includes a plurality of seepage monitoring devices connected through rotary supports. The seepage monitoring devices include first seepage monitoring units symmetrically distributed on the front and back and second seepage monitoring units symmetrically distributed on left and right. Seepage, monitoring fibers are distributed in the first seepage monitoring units and the second seepage monitoring units, and the seepage conditions of the submerged or partially submerged structures are monitored through the seepage monitoring fibers. The heat source-free fiber positioning and orienting system for the seepage of submerged or partially submerged structures has the characteristics of no heating, distribution manner, multiple orientations and synchronicity or the like.

Binary resolution conversion aparatus and method

A binary resolution conversion apparatus and method is provided. According to one exemplary embodiment, a binary resolution conversion method includes an image processing method comprising a data processing process comprising a first video data input process receiving a first video data group associated with one or more horizontal and vertical edges of an image, and one or more horizontal and vertical thin lines of the image; a second video data input process receiving a second video data group associated with one or more slanted edges and one or more slanted lines of the image, and one or more objects of the image; a tag data input process receiving tag data associated with image edge and image thin line detection data; and a first video data input providing the video data output to a first video data output if the tag data input indicates an image edge or image thin line, otherwise a second video data input providing the video data output.

Cleaning device and sweeping assembly thereof

The present disclosure relates to a cleaning device and a sweeping assembly thereof. The sweeping assembly includes: a brush holder; a brush body arranged in the brush holder, and including a cleaning part and a connecting part connected to each other, the connecting part being further connected to the driver to rotate the brush body, the cleaning part including a brush member protruding outward therefrom; and an anti-winding structure arranged at the connecting part, and configured to fill up a gap between the brush holder and the connecting part.

Tile based color space transformation

A system and method for tile type based color space transformation improves the performance and image quality of multifunction devices. The disclosed embodiments transform an input image on a tile by tile basis. If a tile is detected as neutral, simple 1D L* to CMYK Tone Reproduction Curves or Look-Up-Tables are used to convert the input pixels of the tile in L*a*b* to output pixels in CMYK. If a tile is detected as containing color content, then the input pixels are chrominance adjusted and subsequently converted to CMYK using regular tetrahedral interpolation.

SEPARATOR FOR AN ENERGY STORAGE DEVICE

A separator for an electrochemical energy storage device that includes a polypropylene layer and a plurality of ceramic particles selected from at least one of ceramic microparticles and ceramic nanoparticles, wherein the ceramic particles are coated on the polypropylene layer. An electrochemical energy storage device including the aforementioned separator is also disclosed.

Autonomous cleaning robot

The present application provides an autonomous cleaning robot. The autonomous cleaning robot may include a main body and a cleaning assembly mounted on the main body. The cleaning assembly may include a first cleaning subassembly. The first cleaning subassembly is removable mounted on the main body. The first cleaning subassembly can be loaded into or unloaded from the main body in a forward and backward direction. The first cleaning subassembly of the autonomous cleaning robot is easy to be assembled.

RORC2 INHIBITORS AND METHODS OF USE THEREOF

The present invention provides compounds, pharmaceutical compositions, methods of inhibiting RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such compounds and pharmaceutical compositions. 2. The compound of claim 1 , wherein Ris methyl.3. The compound of claim 2 , wherein Y is hydrogen or methyl.11. A pharmaceutical composition comprising a compound according to claim 1 , or a pharmaceutically acceptable salt claim 1 , or pharmaceutically acceptable solvate thereof claim 1 , admixed with a pharmaceutically acceptable carrier claim 1 , excipient or diluent.12. A method for treating an immune disorder or inflammatory disorder comprising administering to a subject in need thereof a pharmaceutical composition of .13. The method of claim 12 , wherein the disorder is an inflammatory disorder.14. The method of claim 12 , wherein the disorder is an autoimmune disorder.15. The method of claim 12 , wherein the disorder is rheumatoid arthritis claim 12 , psoriasis claim 12 , chronic graft-versus-host disease claim 12 , acute graft-versus-host disease claim 12 , Crohn's disease claim 12 , inflammatory bowel disease claim 12 , multiple sclerosis claim 12 , systemic lupus erythematosus claim 12 , Celiac Sprue claim 12 , idiopathic thrombocytopenic thrombotic purpura claim 12 , myasthenia gravis claim 12 , Sjogren's syndrome claim 12 , scleroderma claim 12 , ulcerative colitis claim 12 , asthma claim 12 , epidermal hyperplasia claim 12 , cartilage inflammation claim 12 , bone degradation claim 12 , arthritis claim 12 , juvenile arthritis claim 12 , juvenile rheumatoid arthritis claim 12 , pauciarticular juvenile rheumatoid arthritis claim 12 , polyarticular juvenile rheumatoid arthritis claim 12 , systemic onset juvenile rheumatoid arthritis claim 12 , juvenile ankylosing spondylitis claim 12 , juvenile enteropathic arthritis claim 12 , juvenile Reter's Syndrome claim 12 , SEA Syndrome claim 12 , juvenile ...

AIR-VAPOR SEPARATION DEVICE FOR SEPARATING AIR FROM REFRIGERANT VAPOR AND METHOD THEREOF

The present invention relates to an air-vapor separation device for separating air from refrigerant vapor comprising an air-vapor separation tank, a separation membrane, a mixed gas input passage, a refrigerant vapor output passage, and a control unit, wherein the mixed gas input passage is provided with a compressor and a first control valve, and the refrigerant vapor output passage is provided with a second control valve. The air-vapor separation device of the present invention has the advantages of simple structure, convenient operation, and is reliable and effective in separation of air and refrigerant vapor, with good separation effect.

Charged linkers and their uses for conjugation

Cell binding agent-drug conjugates comprising phosphinate-based charged linkers and methods of using such linkers and conjugates are provided.

Semi-Automatic Communication Network Microsegmentation

A technique for microsegmentation includes receiving information related to hosts and applications operating in a network where the information was obtained based on a survey of the network; identifying a plurality of microsegments utilizing the information, each microsegment includes a set of hosts similar to one another; for each of the plurality of microsegments, identifying security policies that control access to hosts in each microsegment; and providing the plurality of microsegments and corresponding security policies for approval thereof.

Method and system for isolated hole detection and growth in a document image

A method for detecting and growing isolated holes in a document image having a plurality of pixels is provided. The method includes isolating the pixels of the image to form a plurality of windows, each window having a target pixel; identifying a hole growth factor to grow an isolated hole in the received image; using the hole growth factor to identify tiered pixel patterns from a plurality of predefined, tiered pixel patterns, wherein each of the tiered pixel patterns having a predetermined hole growth factor; comparing the pixels within each window to the pixel patterns within the identified tier to identify a match between the pixels within the window and at least one of the pixel patterns; and changing a pixel value of the target pixel, when a match is identified, to grow the isolated hole by the hole growth factor.

PIEZOELECTIRC ENERGY HARVESTING SYSTEM WITH FREQUENCY MISMATCH TOLERANCE

An impedance matching circuit is provided for use with a piezotransducer that includes a parasitic capacitor comprising: an inductor coupled in parallel with the parasitic capacitor; a peak and valley detection circuit configured to detect output voltage waveform peaks and valleys; a first switch circuit configured to bias flip the output voltage waveform at a selectable first time relative to a detected peak and at a selectable first time relative to a detected valley; a second switch circuit configured to couple the inductor to the energy storage circuit at a selectable second time following each output voltage bias flip; an energy monitoring circuit to provide an indication of energy flow from the inductor to the energy storage circuit following each output voltage bias flip; and a maximum power point tracking (MPPT) circuit configured to select the first time and the second time based at least in part upon the indicated energy flow.

REAL-TIME PROCESSING OF GRAYSCALE IMAGE DATA

In a digital reproduction system incorporating a single pass scanner, accurate image processing results from processing a subset of grayscale image data. More specifically, scanlines that correspond to the leading edge of a document are stored and processed to detect skew and to obtain an appropriate correction. The lead edge correction is then applied to the entire grayscale image. Accordingly, the present systems and methods eliminate skew from grayscale images in real-time. The corrected image is rendered to binary and stored in electronic pre-collation memory and cropping, masking and other image editing operations can be performed on the binary image data before the image is printed.

Autonomous cleaning device

An autonomous cleaning device is provided. The autonomous cleaning device includes: a device body; and a drive module, a cleaning module and a sensing module, wherein the drive module, the cleaning module and the sensing module are detachably assembled to the device body, respectively.

Liquid container and autonomous cleaning robot

The present application provides a liquid container and an autonomous cleaning robot. The liquid container may include a container case and a water outlet filter. The container case may define a water outlet (321) thereon and a liquid accommodating room therein. The water outlet communicates with the liquid accommodating room in the container case. The water outlet filter is mounted on the water outlet. The water outlet filter is configured to regulate the rate of the water outlet. The rate of the liquid container is better.

BATTERY

This application relates to a battery comprising a positive electrode plate, a separator, and a negative electrode plate, wherein the positive electrode plate comprises a positive electrode current collector and at least two layers of positive active material coated on at least one surface of the positive electrode current collector, and wherein an underlying positive active material layer in contact with the positive electrode current collector comprises a first positive active material, a first polymer material and a first conductive material; and wherein an upper positive active material layer in contact with the underlying positive active material layer and away from the positive electrode current collector comprises a second positive active material, a second polymer material and a second conductive material, and the first polymer material comprises fluorinated polyolefin and/or chlorinated polyolefin polymer material. The battery has good safety and improved electrical properties.

THIN LINE DETECTION AND ENHANCEMENT FOR ELECTRONIC IMAGES HAVING DIFFERENT RESOLUTIONS

A methodology for thin line detection and enhancement in electronic images is disclosed. The methodology includes associating an electronic image with at least one basic context window that is less than the size of the electronic image based on the input image resolution of the electronic image; detecting one or more predefined patterns which correspond to thin lines in the electronic image using the at least one basic context window; excluding patterns for the one or more detected patterns which are halftone patterns; and adding at least one pixel to the electronic image based on at least one of the remaining patterns so as to enhance thin line features in the electronic image. In some implementation, the methodology may be configured to handle electronic images having different resolutions. A system for thin line detection and enhancement in electronic images having different resolutions is also disclosed.

Document registration and skew detection system

Disclosed methods and systems perform electronic registration of digitally captured images in real-time and performs accurate and robust digital image processing by analyzing the entire digitally captured image.

Alkali-resistant variants of protein A and their use in affinity chromatography

The present invention relates to immunoglobulin (Ig)-binding proteins with alkali-resistance properties. In one embodiment, the present invention provides for a variant of an Ig-binding protein, the variant comprising the Ig-binding protein having at least one asparagine residue substituted with a histidine, a serine, an aspartic acid or a threonine residue. The at least one substitution may confer to the variant Ig-binding protein an increased stability in alkaline solutions when compared to the wild-type Ig-binding. The present invention relates also to matrices for affinity separation of immunoglobulins comprising the Ig-binding proteins of the present invention, and to methods of using the Ig-binding proteins of the present invention to separate immunoglobulins from mixture compositions.

CONNECTED COMPONENT ANALYSIS WITH MULTI-THRESHOLDING TO SEGMENT HALFTONES

Methods and systems receive an input image into a computerized device, create different binary images by applying different threshold measures to the input image using the computerized device, and identify components of a first binary image of the binary images using the computerized device. Such methods and systems also compare pixels of each of the components of the first binary image with corresponding pixels of a second binary image of the binary images to identify pixel differences using the computerized device. This allows these methods and systems to identify halftone areas within the input image based on the pixel differences exceeding a limit using the computerized device.

Optics, device, and system for assaying and imaging

A method of assaying an analyte in a sample is disclosed. The method includes having a sample holder with a sample contact area for contacting a sample with an analyte, having a plurality of calibration structures on the sample contact area of the sample holder, imaging a part of the sample contact area that has the calibration structures, and using an algorithm that includes an image, calibration structures in the image, and artificial intelligence and/or machine learning to identify the analyte and/or determine the analyte concentration.

Thin line detection in scanned image data

Disclosed herein is a method for detecting thin lines in image data. The method is performed by a processor to process contone image data. The processing includes thresholding a window of pixels established in the contone domain to generate a binary window of image data, and then determining characteristics associated with on pixels or runs of the binary data. The characteristics (start and end locations, length of on runs) are then thresholded. The processing in the contone and binary domain are used to determine if a thin line exists in the window of image data. The disclosed method produces better quality output images and reduces the addition of false lines in an image.

Integrated color detection and color pixel counting for billing

Disclosed herein are a method and an image processing apparatus implementing the method for color pixel counting in documents by integrating color detection and counting. The method determines if pixels are neutral (e.g., gray) or non-neutral (i.e., color). Windows are used to analyze the pixels. For each window, a number of pixels with at least one color plane ON are counted, as well as a number of ON pixels in each color plane. The windows are determined to be neutral or color. A billable count of color pixels is determined based on the neutrality of the windows. Based on the billable count of color pixels, a bill for outputting the document is determined.

Scanner calibration using inverse matrix

Methods and systems methods calculate an initial matrix by correlating scanned test device-dependent values to device-independent color space values of a test sheet. The initial matrix converts device-dependent values to device-independent color space values; however, the initial matrix does include some conversion error. Such methods then calculate an inverse matrix from the initial matrix. These methods and systems then calculate target device-dependent values by applying the device-independent color space values to the inverse matrix. The methods and systems derive final one-dimensional look-up tables that isolate the conversion error by correlating the scanned test device-dependent values to the device-independent color space values. These methods and systems then derive a final matrix specific to the scanner by first applying the scanned test device-dependent values to the final one-dimensional look-up tables before creating the final matrix. Then, this final matrix can be substituted ...

Enhanced signal processing for cochlear implants

The restoration of melody perception is a key remaining challenge in cochlear implants. A novel sound coding strategy is proposed that converts an input audio signal into time-varying electrically stimulating pulse trains. A sound is first split into several frequency sub-bands with a fixed filter bank or a dynamic filter bank tracking harmonics in sounds. Each sub-band signal is coherently downward shifted to a low-frequency base band. These resulting coherent envelope signals have Hermitian symmetric frequency spectrums and are thus real-valued. A peak detector or high-rate sampler of half-wave rectified coherent envelope signals in each sub-band further converts the coherent envelopes into rate-varying, interleaved pulse trains. Acoustic simulations of cochlear implants using this new technique with normal hearing listeners, showed significant improvement in melody recognition over the most common conventional stimulation approach used in cochlear implants.

Laser projector

Image-based assay performance improvement

The present invention is related to correct the errors in instruments, operation, and others using intelligent monitoring structures and machine learning, and others.

Detection device and detection method of a GOA circuit of a display panel

A detection device of a GOA circuit of a display panel includes a signal supply unit for supplying a test signal to the GOA circuit; an acquisition unit for determining whether each of the GOA units in the GOA unit group of the GOA circuit has an output signal, if there is an output signal, acquiring the output signal of each of the GOA units in the GOA unit group; wherein part of the GOA units in the GOA circuit constitute the GOA unit group, the GOA unit group at least includes an initial GOA unit and a distal GOA unit of the GOA circuit; a processing unit for determining whether the GOA circuit is abnormal based on the acquired output signal of each of the GOA units in the GOA unit group.

Apolipoprotein nanodiscs with telodendrimer

The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The membrane scaffold protein can be apolipoprotein. The telodendrimer has the general formula PEG-L-D-(R)n, wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a poly(ethylene glycol) polymer; each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Cell free methods of making the nanodiscs are also provided.

Immunomodulatory protein and useful embodiments thereof

The invention generally features the use of Yaba monkey tumor virus nucleic acid molecules and polypeptides for the treatment or prevention of immune-related diseases.

Pixel level segmentation tag cleanup

A system and method of processing segmentation tags is disclosed. In accordance with the present invention, a method for processing segmentation tags that receives blocks of segmentation tags each of which has an associated block level tag that is representative of the segmentation tags within the block. The method positions a neighborhood window about a current block and a neighboring block and cleans a target segmentation tag within the current block based upon the block level tags within the neighborhood window using a set of tag cleaning rules.

Method for an image forming device to process a media, and an image forming device arranged in accordance with the same method

An image forming device includes a backing and is arranged for a media to be positioned against the backing. The backing includes an embedded backing pattern. The media is skewed with respect to the scanning, thus defining a media skew. The media and the backing are scanned to form a pixel pattern. For each pixel, an included pattern recognition algorithm determines when the pixel represents the backing. When the pixel represents the backing, it is replaced with a replacement backing symbol, otherwise it is replaced with a replacement media symbol. The pixel determining and symbol replacing process is continued for remaining pattern pixels to form a replacement symbol pattern comprised of the replacement backing symbols and the replacement media symbols. The media is then processed based on the replacement symbol pattern, the processing including detecting the media skew, registering the media, or both.

METHOD FOR REDUCING REGISTRATION DEFECTS IN COLOR PRINTING

A method and system modify a rasterized digital image to reduce registration artifacts, the image having a black plane and a color plane by determining if a pixel is part of a connected black region and if the pixel is part of a connected color region. It is determined if the pixel is part of a connected black region and a connected color region that are contiguous. A dilation operation is performed on the color plane value of the pixel if the pixel is part of a connected black region and a connected color region that are contiguous.

POSITIVE ELECTRODE COMPOSITE MATERIAL FOR LITHIUM ION SECONDARY BATTERY, POSITIVE ELECTRODE AND BATTERY

A positive electrode composite material for a lithium ion secondary battery, and a positive electrode using the positive electrode composite material for a lithium ion secondary battery, a lithium ion secondary battery and a power consuming device are provided. The positive electrode composite material for a lithium ion secondary battery comprises a positive electrode active material and an alkali metal oxide as shown by formula AmGOn, wherein A represents at least one element selected from Na and K and optionally Li, G represents at least one element selected from Fe, Ni, Co, Mn, Ru, Ir, Sn, Cr, Nb, Mo, V and Ti, m is 1-6, and n is 1-4.

INVERSE HALFTONING USING INVERSE PROJECTION OF PREDICTED ERRORS FOR MULTI-BIT IMAGES

In systems and methods, an original image was previously converted to a lower bit count per pixel. The resulting image included pixel error based on the lower bit count per pixel. The conversion used an error weighting matrix (which diffuses the pixel error of each pixel to adjacent pixels). Methods and systems produce an output image from the lower bit count per pixel image using the error weighting matrix to determine, for each pixel, the amount of error added because of the adjacent pixels during the conversion process. Then, such methods and systems remove, from each pixel, the amount of error that was previously added based on the adjacent pixels. After removing the amount of error added based on the adjacent pixels from all pixels in the input image, an output image is reconstructed using a filter, such as a low pass filter.

Estimating an amount of color content in a document

What is provided herein is a novel system and method for estimating the amount of color in a document. In one embodiment, a binary CMYK input image is received. Each of the CMYK plane is received at an offset from the previous plane, i.e., the 4 planes are not received simultaneously. Each plane is divided into M×N tiles. Pixel values of all four planes are examined separately and the number of on-pixels is counted for each plane. The number of on-pixel counts for each tile are aggregated for each plane. Total on-pixel counts are used to estimate the total number of white, black, color, and gray pixel counts. The total counts for all planes are used to estimate the amount of color. A document is determined to be color if the amount of color exceeds a predetermined threshold. A color billing strategy is determined based on the estimated color amount.

Air-vapor separation method for immersed liquid cooling system and device thereof

The present invention relates to an air-vapor separation method for separating air from refrigerant vapor in an immersed liquid-cooling system. The immersed liquid-cooling system comprises an immersed server blade cabinet, a condensing device, an air-vapor separator and a refrigerant storage tank, wherein the refrigerant storage tank supplies a liquid refrigerant to the immersed server blade cabinet, and the liquid refrigerant undergoes a phase change to be vaporized into a refrigerant vapor for cooling of the heating element in the immersed server blade cabinet; the condensing device condenses the refrigerant vapor; the air-vapor separator separates a mixed gas in the immersed liquid-cooling system into the air and the refrigerant vapor. The cooling efficiency of the liquid-cooling system is improved by effectively separating the air from the refrigerant vapor in the liquid-cooling system.

INVERTER CIRCUIT CONTROL METHOD AND DEVICE THEREOF

An inverter circuit control method and a device thereof are provided. In the control method, after determining a DC bus voltage and an output leakage current of a target inverter circuit, a modulation harmonic wave to be injected into a SPWM signal is adjusted according to the DC bus voltage or the output leakage current if it is determined according to the DC bus voltage that the target inverter circuit satisfies a preset modulation condition, such that total harmonic distortion of a current of the target inverter circuit is within a preset range. The DC bus voltage and the output leakage current of the target inverter circuit are used as references for adjusting the modulation harmonic wave, ensuring total harmonic distortion of the current of the target inverter circuit to be within a preset range.

IMMUNOMODULATORY PROTEIN AND USEFUL EMBODIMENTS THEREOF

The invention generally features the use of Yaba monkey tumor virus nucleic acid molecules and polypeptides for the treatment or prevention of immunoinflammatory disorders.

Resource synchronization control method, device, and system

A method, device and system for resource synchronization control are provided in accordance with the present disclosure. The disclosure relates to a field of information synchronization control. The method for resource synchronization control includes: inquiring, by a first terminal, from a server whether an address of the first terminal in a first terminal list is in a cleared state, the first terminal list has recorded an address of the first terminal; acquiring, by the first terminal, a resource file from a second terminal, if the address of the first terminal is in the cleared state; and notifying, by the first terminal, the server to cancel the cleared state of the address of the first terminal in the first terminal list, after acquiring the resource file.

Positive electrode plate and electrochemical device

The present application relates to a positive electrode plate and an electrochemical device. The positive electrode plate includes a current collector, a positive active material layer and a safety coating disposed between the current collector and the positive active material layer, the safety coating including a polymer matrix and a conductive material, wherein the polymer matrix is fluorinated polyolefin and/or chlorinated polyolefin, and when the safety coating and the positive active material layer are collectively referred to as a positive film layer, the positive film layer includes Na ions and/or K ions at a content of 100 ppm or more, and has an absorption peak at 1646 cm−1 in infrared absorption spectrum. The positive electrode plate may improve safety performance at elevated temperature of the electrochemical device by quickly disconnecting the circuit at high temperature conditions or when an internal short circuit occurs.

Skylight operating system of modular data center

The present invention discloses a skylight operating system of a modular data center, so as to timely respond to a firefighting requirement of the modular data center to reduce occurrence of firefighting-related accidents. The skylight operating system comprises: an electric skylight; a firefighting environment index monitoring device arranged inside the modular data center; a monitoring and interacting device arranged in a monitoring room outside the modular data center, and connected with the electric skylight and the firefighting environment index monitoring device, the monitoring and interacting device adapted for receiving monitoring information of the firefighting environment index monitoring device, and opening the electric skylight upon determination that a firefighting-related issue occurs inside the modular data center.

Positive electrode plate and electrochemical device

This application relates to a positive electrode plate and an electrochemical device. The positive electrode plate includes a current collector, a safety coating, a difficultly soluble layer and a positive active material layer, wherein the safety coating, the difficultly soluble layer and the positive active material layer are successively disposed on the current collector; wherein the safety coating includes a polymer matrix, a conductive material and an inorganic filler; wherein the difficultly soluble layer includes a binder and a conductive agent, and wherein the binder of the difficultly soluble layer has a solubility in an oil solvent smaller than the solubility of the polymer matrix of the safety coating in such oil solvent.

PIEZOELECTRIC IMPACT ENERGY HARVESTING

An electronic circuit can be coupled to an energy harvesting device. The output of the energy harvesting device can provide a damped oscillating waveform elicited from a transient stimulus applied to the energy harvesting device, such as in response to mechanical shock or mechanical impact excitation. A first switch can be coupled between the energy harvesting device and an inductor and configured to selectively connect the input node to the inductor. A second switch can be coupled between the inductor and an energy storage device, the second switch configured to selectively couple the inductor to the energy storage device. A control circuit can be coupled to the first and second switches, such as configured to operate the first and second switches according to one or more of an over bias flip technique, a half bias flip technique, or a bias flip technique.

Positive electrode plate, electrochemical device and safety coating

The present application relates to a positive electrode plate, an electrochemical device and a safety coating. The positive electrode plate comprises a current collector, a positive active material layer and a safety coating disposed between the current collector and the positive active material layer, the safety coating comprising a fluorinated polyolefin and/or chlorinated polyolefin polymer matrix, a conductive material and an inorganic filler. The positive electrode plate can quickly disconnect circuit when the electrochemical device (such as a capacitor, primary battery, or secondary battery, and the like) is in a high temperature condition or an internal short circuit occurs, thereby improving high temperature safety performance of the electrochemical device.

Generating and deploying security policies for microsegmentation

Systems and methods include receiving network communication information about hosts in a network and applications executed on the hosts; automatically generating one or more microsegments in the network based on analysis of the obtained network communication information, wherein each microsegment of the one or more microsegments is a grouping of resources including the hosts and the applications executed on the hosts that have rules for network communication; and providing the one or more microsegments to one or more hosts of the hosts, for use by the one or more hosts to allow or block communications locally based on the one or more microsegments. Each of the one or more microsegments can be a grouping of workloads inside a data center.

Scraps-collecting box

The invention discloses a scraps-collecting box which comprises a box body, and is characterized in that a containing chamber, a suction inlet and a discharge hole are formed on the box body, wherein the containing chamber is positioned inside the box body; and the suction inlet and the discharge hole are communicated with the containing chamber. The scraps-collecting box further comprises a box cover which is used for sealing the discharge hole of the box body, and keeping a certain distance with the box body at the position of the discharge hole for forming a ventilation gap when the discharge hole of the box body is closed; the box cover and the box body are rotatably connected with each other; the box body is provided with a fixing groove; and the box cover is provided with a clamping button for being clamped with the fixing groove. The scraps-collecting box can be used for effectively reducing inside air pressure to guarantee the scrapes-collecting efficiency, and also can be conveniently ...

Preparation method of influenza virus vaccine

The invention discloses a preparation method of influenza virus vaccine and belongs to the technical field of vaccine preparation. The method comprises the steps that: firstly, mammal cells are subjected to monocloning, a monoclonal cell bank is built, then, monoclonal cell strains adapted by influenza viruses are sieved, next, the virus adaptability cell strain virus culture condition is optimized, finally, virus adaptability cell strains are cultured in a bioreactor, influenza viruses are inoculated when the cells grow to a certain density, the viruses are cultured through referring to the optimized virus culture condition, the viruses are subjected to concentration, purification, inactivation and cracking after being harvested, the hemagglutinin content is measured, and the influenza virus vaccine is prepared. The method disclosed by the invention has the advantages that the virus yield is greatly improved, and safety, validity and stability are realized.

Combustion method and system

A method of combustion for pulverized hydrocarbonaceous fuel includes injecting a concentrated fuel and air stream into a burner, causing a low-pressure zone; directing a flow of a high-temperature combustion gas from a combustion chamber into the low-pressure zone in the burner; mixing the high-temperature combustion gas with the injected concentrated stream to heat the injected concentrated stream; injecting the heated concentrated stream from the burner to the combustion chamber, wherein the concentrated stream is rapidly devolatilized and combusted in a flame that has a fuel-rich flame zone; sensing a combustion parameter; and, based on the sensed combustion parameter, controlling combustion to achieve at least one of a desired NOx reduction and a desired distance from the burner to a flame front.

BITMAPPED BASED TRAPPING METHODS, APPARATUS AND SYSTEMS

Provided are bitmap based trapping methods, apparatus and systems. According to one exemplary method, black trapping color image data is performed by estimating the continuous tone values associated with non-black pixels near a qualified black pixel and subsequently, the estimated continuous tone values are halftoned at the qualified black pixel locations and ORed with the original bitmap data.

Efficient Training and Accuracy Improvement of Imaging Based Assay

The present disclosure relates to devices, apparatus and methods of improving the accuracy of image-based assay, that uses imaging system having uncertainties or deviations (imperfection) compared with an ideal imaging system. One aspect of the present invention is to add the monitoring marks on the sample holder, with at least one of their geometric and/optical properties of the monitoring marks under predetermined and known, and taking images of the sample with the monitoring marks, and train a machine learning model using the images with the monitoring mark.

Method and apparatus to add annotations to an image

A method is disclosed. For example, the method is executed by a processor of a multi-function device (MFD) and includes receiving a desired transparency level for an annotation image to be added to a canvas image, applying a transparency factor based on the desired transparency level to a transparency output function and an opaque output function to calculate an output value for each pixel of the canvas image that overlaps a pixel of the annotation image in a color space associated with the MFD, and generating an annotated canvas image that includes the output value that is calculated for each pixel of the canvas image that overlaps the pixel of the annotation image.

Semi-automatic communication network microsegmentation

A technique for microsegmentation includes receiving information related to hosts and applications operating in a network where the information was obtained based on a survey of the network; identifying a plurality of microsegments utilizing the information, each microsegment includes a set of hosts similar to one another; for each of the plurality of microsegments, identifying security policies that control access to hosts in each microsegment; and providing the plurality of microsegments and corresponding security policies for approval thereof.

Method and equipment for preparing fuel from household garbage for suppressing dioxin

The invention relates to a method and equipment for preparing fuel from household garbage for suppressing dioxin. The method comprises the following steps of: introducing a heat source into vertical heat treatment equipment by using high-temperature gas as the heat source to ensure that the heat source is in direct contact with the household garbage in the vertical heat treatment equipment to cause heat transfer; performing thermal cracking reaction after the raw materials are heated; recovering and utilizing the cracked gas phase product; burning out residues caused by thermal cracking; and introducing high-temperature smoke gas generated by burning into the heat treatment equipment to heat the raw materials. The equipment for preparing the fuel from the household garbage for suppressing dioxin provided by the invention mainly comprises the vertical heat treatment equipment for drying the household garbage and performing thermal cracking on the household garbage, equipment for burning ...

Cooling device and manufacturing method therefor

A cooling device of a heating element for an immersion type liquid cooling server, and a manufacturing method for the cooling device. The cooling device comprises: a metal substrate provided on the heating element and covering same. The metal substrate is adjacent to the surface of the heating element. The surface of the metal substrate distant to the heating element comprises a porous metal covering layer located above the heating element and covering same. The porous metal covering layer is exposed on the surface of the metal substrate remote from the heating element and has a thickness of less than 3 mm. By providing a metal substrate having a porous metal covering layer on the surface of a heating element, vaporization cores are improved, the boiling performance of the heating element is improved, and an efficient heat-dissipating effect on the surface of the heating element is achieved.

Color registration error compensation in color printing

A multicolor image can include multiple overlaid items including a black region covering a color region. Raster image processing adds the color data to color pixels of the raster data print page uniformly across the area of the raster data print page that corresponds to the color region of the multicolor image, and adds the black data to over-print pixels (where the black region covers the color region in the multicolor image). Such over-print pixels include both the color data and the black data. The color data (but not the black data) is removed from the over-print pixels that are positioned a preset pixel distance from non-black color pixels. The raster data page is output from the processor device to a printing engine, and the printing device prints the raster data page on print media to produce a physically printed reproduction of the multicolor image.

Charged linkers and their uses for conjugation

Cell binding agent-drug conjugates comprising phosphinate-based charged linkers and methods of using such linkers and conjugates are provided.

Inertial device error simulation method based on positioning accuracy of strapdown inertial navigation system

The invention relates to an inertial device error simulation method based on positioning accuracy of a strapdown inertial navigation system and belongs to the technical field of inertial navigation. The inertial device error simulation method includes the following steps 1, analyzing comprehensive influence of an inertial device random constant and a first-order Markov process on longitude and latitude errors under the static base condition; 2, analyzing influence of the inertial device random constant on the longitude and latitude errors and positioning errors in one-hour simulation time under the static base condition; 3, analyzing influence of the first-order Markov process of an inertial device on the positioning errors in one-hour simulation time under the static base condition; and 4, deducing a method for backstepping inertial device errors through the positioning errors according to a 1 positioning accuracy assessment method and reasonable distribution of the inertial device errors ...

Method and system for image compression

An image compression method includes compressing an input image with first and second compression methods to generate first and second (e.g., lossless and lossy) compressed images. First and second residual layers are generated, based on a difference between the first and second compressed images. Connected components in the residual layers are identified. Each connected component includes a group of one or more pixels that, when mapped to the second compressed image is connected, in first and second directions, to pixels in the second compressed image. A compressed image is generated, which includes, for a connected component identified in the first residual layer, removing corresponding pixels from the second compressed image, and for a connected component identified in the second residual layer, adding corresponding pixels to the second compressed image. The system and method can thus provide file size savings associated with lossy compression while avoiding character replacement.

Piezoelectric energy harvesting system with frequency mismatch tolerance

An impedance matching circuit is provided for use with a piezotransducer that includes a parasitic capacitor comprising: an inductor coupled in parallel with the parasitic capacitor; a peak and valley detection circuit configured to detect output voltage waveform peaks and valleys; a first switch circuit configured to bias flip the output voltage waveform at a selectable first time relative to a detected peak and at a selectable first time relative to a detected valley; a second switch circuit configured to couple the inductor to the energy storage circuit at a selectable second time following each output voltage bias flip; an energy monitoring circuit to provide an indication of energy flow from the inductor to the energy storage circuit following each output voltage bias flip; and a maximum power point tracking (MPPT) circuit configured to select the first time and the second time based at least in part upon the indicated energy flow.

Interface call system and method

Provided is a system and method for interface call, relating to the enterprise management technology field. The system includes: an interface management component which is configured to generate a description file and a call process indication of an interface according to an interface modification requirement of a user, and deploy the description file and the call process indication to an interface execution component, wherein the description file includes configuration replacement information of the interface; and the interface execution component, which is configured to configure the interface according to the description file, and call the interface according to the call process indication.

Enabling a user to select multiple objects in a document

A user is enabled to select multiple objects in a document which is opened in an editor and contains selectable objects by presenting each of the objects as an entry of plurality of entries in a separate window; allowing the user to select multiple entries; and selecting multiple objects corresponding to the selected multiple entries in the editor based on the entries selected by the user. An Assistive Technology application may be called to provide related information and selection state of the operated object based on a user's operation on any one of the entries. The multiple objects can be selected in the document with a keyboard to help disabled users, such as low vision users or blind users.

SYSTEMS AND METHODS FOR DYNAMIC SHARPNESS CONTROL IN SYSTEM USING BINARY TO CONTINUOUS TONE CONVERSION

Embodiments relate to systems and methods for dynamic sharpness control in system using binary to continuous tone conversion. Image data can be processed in the image path of a copier, printer, or other device to enhance sharpness based on user settings. The image can originate in a high-resolution and/or high-color format. The user can select sharpness values to provide better rendered detail. A front-end high-pass 2D filter can be adjusted in response to the settings. A binarized version of the image data is produced in the downstream path. At the back of the image path, the image would conventionally be sent through a binary data to extended contone (BDEC) low-pass filter, set to a fixed level, to produce contone output, counteracting the user's sharpness settings. Instead of applying a fixed back-end filter, that stage can be dynamically adjusted to correspond to the user's sharpness settings, reducing the low-pass effect proportionately.

ISOLATED HOLE DETECTION AND GROWTH

The present disclosure relates to a method and system for processing isolated holes in an image to be printed or displayed. The method includes detecting whether pixels corresponding to an isolated hole in the image are in an off state, determining a sum of pixels that are in an on state in a first pixel ring surrounding the pixels corresponding to the isolated hole when the one or more pixels in the isolated hole are detected to be in the off state, comparing the sum of pixels in the pixel ring that are in the on state with a threshold sum, turning off a number of pixels in at least another pixel ring either comprising of or surrounding the pixels when the first sum of pixels in the on state is greater than the threshold sum, and outputting the isolated hole including the turned off first number of pixels.

BREATHABLE MASK WITH INTEGRATED GOGGLES AND AN AIR FILTER

A breathing mask is provided. The breathing mask is secured around the head of the wearer and includes a nose lifter disposed on the front face of the breathing mask. The breathing mask includes a hood, a pair of eye goggles, a mouth aperture, and a check valve disposed on the rear lace of the hood. The eye goggles are affixed to the hood with an elastic band attached in the rear of the hood. Moreover, the mouth aperture is disposed on the front face of the hood below the nose filter. The hood is secured to the head of the wearer by a zipper disposed on the rear face of the hood and an elastic band encircling a pair of side faces and a rear face of the hood. The elastic band encircling the hood provides an airtight seal to protect the wearer from airborne diseases and other hazards.

Reconfigurable joint track compound mobile robot

A reconfigurable joint track compound mobile robot has a main vehicle body, yaw joints and an auxiliary track module. The main vehicle body has a main track, and a clutch brake and a first wheel joint arranged in a main track driving wheel. A second wheel joint is arranged in a main track driven wheel. The main vehicle body is provided with main track driving mechanisms and a wheel joint driving mechanism. The main track driving wheel is driven to rotate by the main track driving mechanisms, which are connected with the clutch brake. The second wheel joint is driven to rotate by the wheel joint driving mechanism. Each wheel joint is correspondingly connected with the yaw joints, which are rotatably connected with the auxiliary track module. A yaw driving mechanism that drives the auxiliary track module to swing is arranged in each yaw joint.

Systems and methods for optimal dynamic range adjustment of scanned images

A method for dynamic range adjustment of image data of a captured image by determining a white point of an image. The method also involves determining a black point of the image, classifying pixels of the image, and determining an offset value for a pixel of the image based on the determined black point of the image and the determined classification of the pixel. Dynamic range adjustment of the image data is performed using the determined offset value for the pixels of the image and the determined white point of the image.

Detecting skew angle in a scanned image

Detecting skew and determining skew angle using the front of a document by determining background-to-document transitions. Incoming scanlines are interval sampled in the fast scan direction every nth pixel. The samples are collected and organized into a two dimension array comprised of scanline based rows and interval based columns. The collected and organized samples are analyzed by intervals to determine a scanline (row) where a specified sampling condition exceeds predetermined threshold. The corresponding row-interval point forms a background-to-medium transition point of the edge of a document. When two or more background-to-medium transition points are found from different intervals the skew angle can be determined using linear regression.

NEUTRAL PIXEL DETECTION IN AN IMAGE PATH

What is disclosed is a novel system and method for pixel and object level neutral detection. In one embodiment, an image is scanned into a plurality of pixels. A local pixel of interest is identified along with a neighborhood of pixels around the local pixel. The chroma value of the current pixel as well as the average local chroma of the neighborhood are calculated. An adjusted chroma is determined based on the average local chroma. A luminance value can also be measured for the current pixel and for each of the neighbor pixels and a luminance variation determined. The adjusted chroma can be further modified based on the determined luminance variation. The adjusted chroma is compared against a threshold to determine a neutral pixel detection tag for the current pixel. The pixel tags can be utilized to control an adjustment of pixels in a device independent L*a*b* or CMYK domain.

MULTI-BIT ERROR DIFFUSION

The present invention generally relates to systems and methods for error diffusion, e.g., for use in a halftone process. The described techniques are faster than known techniques in that they utilize fewer computations on average. Consequently, the described techniques can be more readily implemented in software, for example, though the described techniques are not limited to software.

ELECTRODE ASSEMBLY AND RELATED BATTERY, DEVICE, MANUFACTURING METHOD, AND MANUFACTURING DEVICE

An electrode assembly and related battery, device, manufacturing method, and manufacturing device are provided. In some embodiments, the electrode assembly includes: a first electrode plate and a second electrode plate that are of opposite polarities, where an active material region of the first electrode plate and an active material region of the second electrode plate are wound to form a body portion, a non-active material region of the first electrode plate or a non-active material region of the second electrode plate is wound to form a tab, and the tab includes a bend portion bent against the body portion; and a guide piece. At least a part of the guide piece is located in the bend portion, and the guide piece is configured to guide an electrolytic solution into an interior of the body portion.

Image segmentation apparatus and method

A method and apparatus are provided for classifying image data. A peak/valley detection device may count peaks and valleys within a window. A local roughness of the image data may be determined and the data may be classified based on the peak/valley count and the local roughness.

Method and device for realizing remote login

The present disclosure provides a method and a device for realizing remote login. The method includes: a terminal server responding to a login request to an internal system from an end user, and recording and saving login information of the end user for logging in to the internal system; and the terminal server judging and analyzing the way the end user logs in to the internal system according to the login information and pre-configured rule, and allowing the end user to log in to and access the internal system if the analyzed result matches the pre-configured rule. The method and device allows for implementations of the SSO authentication and user bind authentication on the aspect of the data flow in the terminal server, simplifies the process of logging in to and accessing the internal system, and improves the information security of the system.

Segmentation of image data

In an image processing system, successive segmentation steps are carried out. In the case of a “hole” in the segmentation result, which is defined as a small area of one type (such as black) within a slightly larger “island” of another type (such as white), a basic segmentation technique may result in an error. The error is avoided by retaining, for each distinct area in the image, a variable indicating whether the area has been “flipped” from one type to another in a previous processing operation.

METHOD FOR ENHANCING BOILING PERFORMANCE OF CHIP SURFACE

The present invention relates to a method for enhancing boiling performance of chip surface comprising steps of mounting a heat pipe directly above the surface of the chip, and forming a porous structure for increasing the vaporization core on an upper surface of the heat pipe. Performing an enhancing treatment in boiling of the upper surface of the heat pipe by mounting the heat pipe directly above the chip makes a temperature field of the boiling surface uniform, increases the boiling area and vaporization core, strengthens the boiling heat transfer, and reduces the core temperature of the chip.

MULTIPLE ANTIGEN DELIVERY SYSTEM USING HEPATITIS E VIRUS-LIKE PARTICLE

This invention provides a peptide/nucleic acid composition for oral/mucosal, dual-modal activation of immune protection systems. 1. A composition comprising:a modified hepatitis E virus (HEV) capsid protein comprising a portion of HEV ORF 2 protein and a heterologous peptide; anda heterologous nucleic acid encapsulated in a chimeric virus-like particle (VLP) formed by the modified HEV capsid protein.2. The composition of claim 1 , wherein the heterologous nucleic acid and the heterologous peptide are from the same source.3. The composition of claim 1 , wherein the heterologous nucleic acid and the heterologous peptide are from different sources.4. The composition of claim 1 , wherein the modified hepatitis E virus (HEV) capsid protein comprising a portion of HEV ORF 2 protein and two or more heterologous peptides.5. The composition of claim 1 , wherein the two or more heterologous peptides are from different sources.6. The composition of claim 1 , wherein the two or more heterologous peptides are from the same source.7. The composition of claim 1 , wherein the modified HEV capsid protein comprises residues 112-608 of HEV ORF 2 protein.8. The composition of claim 7 , wherein the modified HEV capsid protein further comprises residues 91-123 of HEV ORF 3 protein fused to the N-terminal of residues 112-608 of the HEV ORF 2 protein.9. The composition of claim 7 , wherein the modified HEV capsid protein further comprises residues 70-123 of HEV ORF 3 protein fused to the N-terminal of residues 112-608 of the HEV ORF 2 protein.10. The composition of claim 1 , wherein the heterologous peptide is located at the C-terminal of the modified HEV capid protein.11. The composition of claim 1 , wherein the heterologous peptide is located at the N-terminal of the modified HEV capid protein.12. The composition of claim 1 , wherein the heterologous peptide is inserted into the portion of HEV ORF 2 within a pre-selected region of residues 483-490 claim 1 , residues 530-535 claim 1 , ...

Determining an orientation direction of a color edge at a pixel location in a color image

What is disclosed is a system and method for determining an orientation direction of a color edge at a given pixel location in a binary color image. The orientation direction of the color edge is determined from eight pixel counts with each pixel count being a total number of pixels in each of eight regions of a window centered about a candidate pixel which resides along the color edge. The eight regions are associated with 8 compass points. The orientation of the edge is determined by a 1 st , 2 nd and 3 rd tier control bits which are based upon the pixel counts of each region. The 1 st , 2 nd and 3 rd tier control bits collectively form a 3-bit word. The 3-bit word defines the orientation direction. The teachings hereof provide an efficient way of performing binary edge orientation detection by making uses of intermediate results to simultaneously encode the edge orientation.

Method and system for job separation in high volume document scanning

A method for job separation in a high volume document scanning is provided. The method includes monitoring a document receiver with a monitor device to determine when a batch of documents has been received by the document receiver and in response to the monitor device determining the batch of documents has been received by the document receiver, automatically inserting a job separation document with a separation document inserter at an end of the batch to separate the batch of documents from a successive batch of documents.

PROTEOLYSIS-RESISTANT CAPSID OF CHIMERIC HEPATITIS E VIRUS AS AN ORAL DELIVERY VECTOR

This invention provides a peptide/nucleic acid composition for oral/mucosal, dual-modal activation of immune protection systems. 1. A composition comprising:a modified hepatitis E virus (HEV) capsid protein comprising a portion of HEV ORF 2 protein and a heterologous peptide, wherein the heterologous peptide is inserted into the portion of HEV ORF 2 after residue Tyr485; anda heterologous nucleic acid encapsulated in a chimeric virus-like particle (VLP) formed by the modified HEV capsid protein.2. The composition of claim 1 , wherein the heterologous nucleic acid and the heterologous peptide are from the same source.3. The composition of claim 1 , wherein the heterologous nucleic acid and the heterologous peptide are from different sources.4. The composition of claim 1 , wherein the modified HEV capsid protein comprising a portion of HEV ORF 2 protein and two or more heterologous peptides.5. The composition of claim 1 , wherein the two or more heterologous peptides are from different sources.6. The composition of claim 1 , wherein the two or more heterologous peptides are from the same source.7. The composition of claim 1 , wherein the modified HEV capsid protein comprises residues 112-608 of HEV ORF 2 protein.8. The composition of claim 1 , wherein the heterologous peptide is the p18 epitope of HIV Env gp120 (RIQRGPGRAFVTIGK).9. The composition of claim 1 , wherein the modified HEV capsid protein consists of residues 112-608 of HEV ORF 2 protein and p18 inserted after Tyr485.10. A composition of any one of the previous claims claim 1 , further comprising a pharmaceutically acceptable excipient.11. A composition of claim 10 , wherein the excipient is an adjuvant.12. A composition of claim 10 , wherein the excipient is adapted for oral delivery.13. A composition of claim 10 , wherein the excipient is adapted for mucosal delivery.14. A method of inducing an immunogenic response in a host claim 10 , comprising the step of administering the composition of any one of the ...

ELECTRIC CIRCULAR SAW

An electric circular saw includes a housing, a switch trigger arranged on the housing, a switch controlling rod for limiting the travel range of the switch trigger, a base plate, a depth support arranged on the base plate and a connecting rod for limiting the travel range of the depth support. The electric circular saw further includes an movable control member having a driving portion for driving the first connecting rod and a limiting portion for limiting the switch controlling rod, and the moving distance from the driving portion to a contact surface between the driving portion and the first connecting rod is larger than or equal to the moving distance from the limiting portion to a contact surface between the limiting portion and the switch controlling rod. 1. An electric circular saw , comprisinga housing;a switch trigger arranged on the housing;a switch controlling rod for limiting the travel range of the switch trigger, wherein the switch controlling rod is pivotally mounted to the inner wall of the housing through a pin shaft, a stopping member for limiting the travel range of the switch trigger is arranged between the switch controlling rod and the switch trigger, and the rotation of the switch controlling rod forces the stopping member to get out of the travel range of the switch trigger so as to control the operation of the switch trigger, the switch controlling rod further comprises an elastic member for causing the switch controlling rod to force the stopping member to restore towards the switch trigger, and the switch controlling rod is more connected with a pushing button protruding out from the housing in a normal state;a base plate;a depth support arranged on the base plate;a first connecting rod for limiting the travel range of the depth support;a rotary plate arranged in the housing, the rotary plate comprising a first convex portion protruding outwards from a side of the rotary plate for driving the first connecting rod, and a second convex ...

Isolated hole detection and growth

The present disclosure relates to a method and system for processing isolated holes in an image to be printed or displayed. The method includes generating a random number lying in a finite range of numbers, determining whether a target pixel is to be turned off and enabled for printing as a hole, determining a sum of pixels surrounding a target pixel in a plurality of pixels in a scanline of the image, the target pixel corresponding to an isolated hole in an input image, that are in an on state, the on state defined by a higher binary logic level relative to a binary logic level corresponding to a turned off pixel, determining a numerical value stored in a lookup table in a memory unit coupled to the processor using the determined number of pixels that are in the turned on state surrounding the target pixel.

Systems and methods for computation-efficient image processing system architecture

Embodiments relate to systems and methods for a computation-efficient image processing system architecture. Image data can be transmitted from a computer, online service, and/or other image source to an output device having a set of image processing modules in two or more image paths, including an edge detection module and a video decoding module. The edge detection module can produce edge tag output, and the video decoding module, operating in parallel, can generate decoded video output. The edge tag output and decoded video output can be transmitted to a set of downstream image processing modules, including modules for color trapping, edge smoothing, and other operations. Because earlier processing stages share information with downstream modules which require the same or related data, redundant processing can be reduced or eliminated. Complex image operations can therefore be carried out, and high-quality output can be generated, without sacrificing responsiveness.

Methyoxy-Substituted Pyrrolopyridine Modulators of RORC2 and Methods of Use Thereof

The present invention provides methoxy-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof. 2. The compound of claim 1 , wherein Ris —CH.36-. (canceled)8. (canceled)10. (canceled)11. The compound of claim 9 , wherein X is phenyl substituted with —CN and optionally substituted with one or two substituents independently selected from the group consisting of —CH claim 9 , —CHCH claim 9 , —CHOH claim 9 , —OH claim 9 , —OCH claim 9 , —SCH claim 9 , —OCHCH claim 9 , —OCHCHOH claim 9 , —OCHCHOCH claim 9 , —F claim 9 , —Cl claim 9 , —Br and —CN.12. (canceled)14. (canceled)15. The compound of claim 13 , wherein Ris (C-C)alkyl.1619-. (canceled)20. The compound of claim 13 , wherein Ris unsubstituted (C-C)cycloalkyl.2122-. (canceled)25. A pharmaceutical composition comprising a compound according to thereof claim 1 , admixed with a pharmaceutically acceptable carrier claim 1 , excipient or diluent.26. (canceled)27. A method for treating an immune disorder or inflammatory disorder in a subject comprising administering to the subject in need of such treatment a therapeutically effective amount of a compound according to claim 1 , or a pharmaceutically acceptable salt thereof.28. The method of claim 27 , wherein the disorder is an inflammatory disorder.29. The method of claim 27 , wherein the disorder is an autoimmune disorder.30. The method of claim 27 , wherein the disorder is rheumatoid arthritis claim 27 , psoriasis claim 27 , chronic graft-versus-host disease claim 27 , acute graft-versus-host disease claim 27 , Crohn's disease claim 27 , inflammatory bowel disease claim 27 , multiple sclerosis claim 27 , systemic lupus erythematosus claim 27 , Celiac Sprue claim 27 , idiopathic thrombocytopenic thrombotic purpura claim 27 , myasthenia gravis claim 27 , ...

Bruton's Tyrosine Kinase Inhibitors

Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions. (Formula I) 2. The compound of claim 1 , wherein R is cyano or cyano(C-C)alkyl.6. The compound of claim 4 , wherein Ris hydrogen.7. The compound of claim 1 , wherein X is O claim 1 , CHor C(═O).8. The compound of claim 1 , wherein X is O.9. The compound of claim 1 , wherein X is CH.10. The compound of claim 1 , wherein W is phenyl optionally substituted with one claim 1 , two claim 1 , three claim 1 , four or five Rindependently selected for each occurrence from the group consisting of (C-C)alkyl claim 1 , halo(C1-C3)alkyl claim 1 , (C-C)alkoxy claim 1 , and halo.12. The compound of claim 1 , wherein W is pyridyl optionally substituted with one claim 1 , two claim 1 , three claim 1 , or four Rindependently selected from the group consisting of (C-C)alkyl claim 1 , halo(C-C)alkyl claim 1 , halo claim 1 , hydroxy claim 1 , hydroxy(C-C)alkyl claim 1 , (C-C)alkoxy claim 1 , and (C-C)haloalkoxy.21. A pharmaceutical composition comprising a compound according to claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , admixed with a pharmaceutically acceptable carrier claim 1 , excipient or dilutent.2225-. (canceled)26. A method for treating a cancer in a subject comprising administering to the subject in need thereof a therapeutically effective amount of the pharmaceutical composition according to .27. The method of claim 26 , wherein the cancer is a B-cell proliferative disorder.28. The method of claim 27 , wherein the B-cell proliferative disorder is chronic lymphocytic ...

MACROCYCLIC COMPOUNDS FOR MODULATING IL-17

The invention relates generally to macrocyclic compounds of formula I and their therapeutic use. More particularly, the invention relates to macrocyclic compounds that modulate the activity of IL-17 and/or are useful in the treatment of medical conditions, such as inflammatory diseases and other IL-17-associated disorders. 2. The compound of claim 1 , wherein R′ is selected from —O— claim 1 , —N(H)— and —N(CH)—.3. The compound of claim 1 , wherein Ris selected from *—CH(R)—Z— and *—C(H)(R)—X—C(H)(R)—N(R)—C(O)—C(H)(R)—(CH)— claim 1 , wherein:{'sub': 2', '2', '2', '2', '2', '3', '2', '2', '2', '2', '2', '3, 'X is selected from —CH—O—CH—, —CH—N(H)—CH—, —CH—N(CH)—CH—, —CH—, —(CH)—, and —(CH)—;'}{'sub': 2', '8', '2', '8', '2', '8', '3, 'Z is selected from C-Calkylene, C-Calkenylene, or C-Calkynylene, wherein up to 2 methylene units in Z are optionally and independently replaced with —O—, —N(H)— or —N(CH)—;'}{'sup': 10', '10, 'each Ris independently selected from hydrogen and —(R)—COOH, wherein at least one Ris hydrogen;'}{'sup': '11', 'sub': 2', '3', '3', '3', '2', '2', '2', '2', '2', '2', '2', '2', '4', '2, 'Ris selected from hydrogen, (S)—CHOH, (S)—CH, (S)—C(CH), (S)-benzyl, (R)-benzyl, (S)—CH-pyridinyl, (S)-cyclohexyl, (S)—CH-cyclohexyl, (S)—(CH)—COOH, (S)—(CH)—C(O)NH, and (S)—(CH)—NH;'}{'sup': '12', 'sub': '3', 'Ris selected from hydrogen and —CH; and'}{'sup': 2', '1, '“*” represents a terminus of Rbound to R.'}4. The compound of claim 1 , wherein Ris selected from *—(CH)— claim 1 , *—CH(COOH)—(CH)— claim 1 , *—(CH)—O—(CH)— claim 1 , *—(CH)—O—(CH)—O—(CH)— claim 1 , *—(CH)—NH—(CH)— claim 1 , *—(CH)—N(CH)—(CH)— claim 1 , *—CH—C≡C—(CH) claim 1 , and *—CH—CH═CH—(CH).7. The compound of claim 1 , wherein Ris selected from —(CH)— and —CH-(1 claim 1 ,4-phenylene)-† claim 1 , wherein “†” represents a portion of Rbound to N(R).8. The compound of claim 1 , wherein Ris —CH-(1 claim 1 ,4-phenylene)-†; and the stereochemistry of the carbon adjacent to Ris (5).9. The compound of ...

CHEMICALLY ACTIVATED NANOCAPSID FUNCTIONALIZED FOR CANCER TARGETING

Modified capsid proteins containing at least a portion of hepatitis E virus (HEV) open reading frame 2 (ORF2) having one or more cysteine residues in a surface variable loop or the C-terminus of HEV ORF2, or a portion thereof, are provided. The modified capsid proteins can be used to form hepatitis E virus (HEV) virus like particles (VLPs) having cysteine functional groups exposed on the outer-surface. The exposed cysteine functional groups can be modified via their thiol reactive group. For example, a bioactive agent, such as a cell-targeting ligand, can be conjugated to the one or more cysteines for targeted delivery of chemically activated nanocapsids. 1. A modified capsid protein comprising a portion of hepatitis E virus (HEV) open Reading Frame 2 (ORF2) protein that is able to form an acid and proteolytically stable HEV virus like particle (VLP) , wherein:the portion of HEV ORF2 comprises a P-domain of the HEV ORF2 protein;the P-domain comprises at least one surface variable loop and a C-terminus;the P-domain comprises a cysteine in the at least one surface variable loop or at the C-terminus; andthe HEV ORF2 portion retains its ability to form an acid and proteolytically stable HEV VLP when the surface variable loop or C-terminal cysteine is chemically derivatized.2. The modified capsid protein of claim 1 , wherein the HEV ORF2 portion retains its ability to form an acid and proteolytically stable HEV VLP when the surface variable loop or C-terminal cysteine is alkylated claim 1 , agitated claim 1 , arylated claim 1 , succinylated claim 1 , oxidized claim 1 , or conjugated to a detectable label or bioactive agent.3. The modified capsid protein of or claim 1 , wherein the modified capsid protein comprises an amino acid sequence at least 90% claim 1 , 95% claim 1 , or 99% identical claim 1 , or identical claim 1 , to residues 112-608 of the HEV ORF2 protein of SEQ ID NO:1 claim 1 , 2 claim 1 , 3 claim 1 , 4 claim 1 , 5 claim 1 , or 6.4. The modified capsid ...

AMINOPYRIMIDINYL COMPOUNDS

A compound having the structure: 5. A compound of selected from the group consisting of:[(1S)-2,2-difluorocyclopropyl]{(1R,5S)-3-[2-({5-fluoro-6-[(3S)-3-hydroxypyrrolidin-1-yl]pyridin-3-yl}amino)pyrimidin-4-yl]-3,8-diazabicyclo[3.2.1]oct-8-yl}methanone;(1R,5S)—N-ethyl-3-[2-(1,2-thiazol-4-ylamino)pyrimidin-4-yl]-3,8-diazabicyclo[3.2.1]octane-8-carboxamide;4-{(1R,5S)-8-[(2,2-difluorocyclopropyl)methyl]-3,8-diazabicyclo[3.2.1]oct-3-yl}-N-(1H-pyrazol-4-yl)pyrimidin-2-amine;(1R,5S)-3-(2-{[5-chloro-6-(methylcarbamoyl)pyridin-3-yl]amino}pyrimidin-4-yl)-N-ethyl-3,8-diazabicyclo[3.2.1]octane-8-carboxamide;cyclopropyl[(1R,5S)-3-(2-{[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]amino}pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]oct-8-yl]methanone;N-(1-methyl-1H-pyrazol-4-yl)-4-{(1R,5S)-8-[1-(methylsulfonyl)azetidin-3-yl]-3,8-diazabicyclo[3.2.1]oct-3-yl}pyrimidin-2-amine;4-({4-[(1R,5S)-8-{[(1S)-2,2-difluorocyclopropyl]carbonyl}-3,8-diazabicyclo[3.2.1]oct-3-yl]pyrimidin-2-yl}amino)-N,6-dimethylpyridine-2-carboxamide;5-({4-[(1R,5S)-8-{[(1R,2S)-2-fluorocyclopropyl]carbonyl}-3,8-diazabicyclo[3.2.1]oct-3-yl]pyrimidin-2-yl}amino)-N,3-dimethylpyridine-2-carboxamide;cyclopropyl[(1R,5S)-3-{2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}-3,8-diazabicyclo[3.2.1]oct-8-yl]methanone;3-{(1R,5S)-3-[2-(1H-pyrazol-4-ylamino)pyrimidin-4-yl]-3,8-diazabicyclo[3.2.1]oct-8-yl}butanenitrile;5-({4-[(1R,5S)-8-(cyclopropylcarbonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl]pyrimidin-2-yl}amino)-N-ethyl-3-methylpyridine-2-carboxamide;3-[(1R,5S)-3-{2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}-3,8-diazabicyclo[3.2.1]oct-8-yl]butanenitrile;5-({4-[(1R,5S)-8-(cyclopropylcarbonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl]pyrimidin-2-yl}amino)-3-methylpyridine-2-carboxamide;(1R,5S)—N-ethyl-3-(2-{[5-fluoro-6-(methylcarbamoyl)pyridin-3-yl]amino}pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octane-8-carboxamide;3-chloro-5-({4-[(1R,5S)-8-(cyclopropylcarbonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl]pyrimidin-2-yl}amino)-N-methylpyridine-2-carboxamide;(1R, ...

RORC2 INHIBITORS AND METHODS OF USE THEREOF

The present invention provides compounds, pharmaceutical compositions, methods of inhibiting RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such compounds and pharmaceutical compositions. 2. The compound of claim 1 , wherein Ris methyl.3. The compound of claim 2 , wherein Y is hydrogen or methyl.11. A pharmaceutical composition comprising a compound according to claim 1 , or a pharmaceutically acceptable salt claim 1 , or pharmaceutically acceptable solvate thereof claim 1 , admixed with a pharmaceutically acceptable carrier claim 1 , excipient or diluent.12. A method for treating an immune disorder or inflammatory disorder comprising administering to a subject in need thereof a pharmaceutical composition of .13. The method of claim 12 , wherein the disorder is an inflammatory disorder.14. The method of claim 12 , wherein the disorder is an autoimmune disorder.15. The method of claim 12 , wherein the disorder is rheumatoid arthritis claim 12 , psoriasis claim 12 , chronic graft-versus-host disease claim 12 , acute graft-versus-host disease claim 12 , Crohn's disease claim 12 , inflammatory bowel disease claim 12 , multiple sclerosis claim 12 , systemic lupus erythematosus claim 12 , Celiac Sprue claim 12 , idiopathic thrombocytopenic thrombotic purpura claim 12 , myasthenia gravis claim 12 , Sjogren's syndrome claim 12 , scleroderma claim 12 , ulcerative colitis claim 12 , asthma claim 12 , epidermal hyperplasia claim 12 , cartilage inflammation claim 12 , bone degradation claim 12 , arthritis claim 12 , juvenile arthritis claim 12 , juvenile rheumatoid arthritis claim 12 , pauciarticular juvenile rheumatoid arthritis claim 12 , polyarticular juvenile rheumatoid arthritis claim 12 , systemic onset juvenile rheumatoid arthritis claim 12 , juvenile ankylosing spondylitis claim 12 , juvenile enteropathic arthritis claim 12 , juvenile Reter's Syndrome claim 12 , SEA Syndrome claim 12 , juvenile ...

RORC2 INHIBITORS AND METHODS OF USE THEREOF

The present invention provides compounds, pharmaceutical compositions, methods of inhibiting RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such compounds and pharmaceutical compositions. 2. The compound of claim 1 , wherein the compound is represented by Formula I or Formula II claim 1 , or pharmaceutically acceptable salts claim 1 , pharmaceutically active metabolites claim 1 , pharmaceutically acceptable prodrugs claim 1 , or pharmaceutically acceptable solvates thereof.3. The compound of claim 1 , wherein Ris hydrogen or methyl.4. The compound of claim 1 , wherein Y is hydrogen or methyl.12. A pharmaceutical composition comprising a compound according to claim 1 , or a pharmaceutically acceptable salt claim 1 , pharmaceutically active metabolite claim 1 , pharmaceutically acceptable prodrug claim 1 , or pharmaceutically acceptable solvate thereof claim 1 , admixed with a pharmaceutically acceptable carrier claim 1 , excipient or dilutant.13. A method of inhibiting RORC2 comprising of administering to a patient an effective amount of a pharmaceutical composition of .14. A method for treating an immune disorder or inflammatory disorder comprising administering to a subject in need thereof a pharmaceutical composition of .15. The method of claim 14 , wherein the disorder is an inflammatory disorder.16. The method of claim 14 , wherein the disorder is an autoimmune disorder.17. The method of claim 14 , wherein the disorder is rheumatoid arthritis claim 14 , psoriasis claim 14 , chronic graft-versus-host disease claim 14 , acute graft-versus-host disease claim 14 , Crohn's disease claim 14 , inflammatory bowel disease claim 14 , multiple sclerosis claim 14 , systemic lupus erythematosus claim 14 , Celiac Sprue claim 14 , idiopathic thrombocytopenic thrombotic purpura claim 14 , myasthenia gravis claim 14 , Sjogren's syndrome claim 14 , scleroderma claim 14 , ulcerative colitis claim 14 , asthma ...

Slanted type card edge connector assembly

A card edge connector includes an insulative housing with a pair of opposite side walls extending along a longitudinal direction with a central slot therebetween in the transverse direction perpendicular to the longitudinal direction. A pair of towers are located at two opposite ends of the housing in the longitudinal direction. The housing is essentially obliquely mounted upon a printed circuit board. Each tower has a lower/first part and an upper/second part in the vertical direction perpendicular to the longitudinal direction and the transverse direction. The width dimension in the transverse direction of the upper part is smaller than that of the lower part.

Full-span forward swept airfoils for gas turbine engines

Rotor of a gas turbine engines having a rotor hub and a plurality of blades extending from the rotor hub, wherein each blade has a full-span forward sweep along a leading edge of the blade that starts at an airfoil root of the blade at the hub and extends to a blade tip, wherein a sweep of a blade is a percentage of a root axial chord length of the respective blade.

RORC2 INHIBITORS AND METHODS OF USE THEREOF

The present invention provides compounds, pharmaceutical compositions, methods of inhibiting RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such compounds and pharmaceutical compositions. 2. The compound of claim 1 , wherein Ris methyl.3. The compound of claim 2 , wherein Y is hydrogen or methyl.11. A pharmaceutical composition comprising a compound according to claim 1 , or a pharmaceutically acceptable salt claim 1 , or pharmaceutically acceptable solvate thereof claim 1 , admixed with a pharmaceutically acceptable carrier claim 1 , excipient or diluent.12. A method for treating an immune disorder or inflammatory disorder comprising administering to a subject in need thereof a pharmaceutical composition of .13. The method of claim 12 , wherein the disorder is an inflammatory disorder.14. The method of claim 12 , wherein the disorder is an autoimmune disorder.15. The method of claim 12 , wherein the disorder is rheumatoid arthritis claim 12 , psoriasis claim 12 , chronic graft-versus-host disease claim 12 , acute graft-versus-host disease claim 12 , Crohn's disease claim 12 , inflammatory bowel disease claim 12 , multiple sclerosis claim 12 , systemic lupus erythematosus claim 12 , Celiac Sprue claim 12 , idiopathic thrombocytopenic thrombotic purpura claim 12 , myasthenia gravis claim 12 , Sjogren's syndrome claim 12 , scleroderma claim 12 , ulcerative colitis claim 12 , asthma claim 12 , epidermal hyperplasia claim 12 , cartilage inflammation claim 12 , bone degradation claim 12 , arthritis claim 12 , juvenile arthritis claim 12 , juvenile rheumatoid arthritis claim 12 , pauciarticular juvenile rheumatoid arthritis claim 12 , polyarticular juvenile rheumatoid arthritis claim 12 , systemic onset juvenile rheumatoid arthritis claim 12 , juvenile ankylosing spondylitis claim 12 , juvenile enteropathic arthritis claim 12 , juvenile Reter's Syndrome claim 12 , SEA Syndrome claim 12 , juvenile ...

Methyl- and Trifluoromethyl-Substituted Pyrrolopyridine Modulators of RORC2 and Methods of Use Thereof

The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof. 2. The compound of claim 1 , wherein Y is —CH.3. The compound of claim 1 , wherein Y is —CF.4. The compound of claim 1 , wherein Ris —CH.13. The compound of claim 1 , wherein X is phenyl substituted with one claim 1 , two claim 1 , three claim 1 , four or five substituents independently selected from the group consisting of —CH claim 1 , —CHCH claim 1 , —CHOH claim 1 , —OH claim 1 , —OCH claim 1 , —SCH claim 1 , —OCHCH claim 1 , —OCHCHOH claim 1 , —OCHCHOCH claim 1 , —F claim 1 , —Cl claim 1 , —Br and —CN.14. The compound of claim 1 , wherein X is phenyl substituted with —CN and optionally substituted with one or two substituents independently selected from the group consisting of —CH claim 1 , —CHCH claim 1 , —CHOH claim 1 , —OH claim 1 , —OCH claim 1 , —SCH claim 1 , —OCHCH claim 1 , —OCHCHOH claim 1 , —OCHCHOCH claim 1 , —F claim 1 , —Cl claim 1 , —Br and —CN.15. The compound of claim 1 , wherein X is phenyl substituted with —Cl and optionally substituted with one or two substituents independently selected from the group consisting of —CH claim 1 , —CHCH claim 1 , —CHOH claim 1 , —OH claim 1 , —OCH claim 1 , —SCH claim 1 , —OCHCH claim 1 , —OCHCHOH claim 1 , —OCHCHOCH claim 1 , —F claim 1 , —Cl claim 1 , —Br and —CN.17. The compound of claim 1 , wherein Ris (C-C)alkyl optionally substituted with one claim 1 , two claim 1 , three claim 1 , four or five substitutents independently selected for each occurrence from the group consisting of —F claim 1 , —Cl claim 1 , —Br claim 1 , —OH claim 1 , (C-C)alkyl claim 1 , (C-C)haloalkyl and (C-C)cycloalkyl.18. The compound of claim 1 , wherein Ris (C-C)alkyl.19. The compound of claim 1 , wherein Ris ...

Positive electrode plate, and lithium-ion battery and apparatus related thereto

This application provides a positive electrode plate includes a positive electrode current collector, a first positive electrode membrane, and a second positive electrode membrane. The first positive electrode membrane includes a first positive electrode active material selected from one or more of phosphate materials LiFe1-x-yMnxMyPO4, where 0≤x≤1, 0≤y≤0.1, 0≤x+y≤1, M is selected from one or more of Cr, Mg, Ti, Al, Zn, W, Nb, or Zr. The second positive electrode membrane is arranged on the first positive electrode membrane and includes a second positive electrode active material, gram capacity of the second positive electrode active material is greater than gram capacity of the first positive electrode active material, the second positive electrode active material is different from the first positive electrode active material. Thickness D0 of the positive electrode current collector is less than or equal to thickness D1 of the first positive electrode membrane.

SANDING TOOL

A sanding tool includes a machine body, a power supply, a base plate assembly, a drive mechanism, and a control mechanism. The machine body includes a casing. The base plate assembly includes a base plate. The drive mechanism is disposed in the casing and includes a motor and an output shaft, the motor has a motor shaft rotating around a first axis, the output shaft rotates around a second axis, and the output shaft transmits power to the base plate assembly. The control mechanism is electrically connected to the motor and configured to control the sanding tool to operate. The first axis and the second axis form an included angle and are not in the same plane. A battery pack and the motor are disposed on two sides of the output shaft. 1. A sanding tool , comprising:a machine body comprising a casing;a battery pack disposed at a rear end of the machine body;a base plate assembly comprising a base plate;a drive mechanism disposed in the casing and comprising a motor and an output shaft, wherein the motor has a motor shaft rotating around a first axis, the output shaft rotates around a second axis, and the output shaft transmits power to the base plate assembly to drive the base plate assembly to move; anda control mechanism electrically connected to the motor and configured to control the sanding tool to operate;wherein the first axis and the second axis form an included angle and are not in a same plane and the battery pack and the motor are disposed on two sides of the output shaft.2. The sanding tool of claim 1 , wherein the motor shaft is parallel to a plane where the base plate is located.3. The sanding tool of claim 1 , wherein the battery pack comprises a coupling surface on which a battery pack terminal is disposed and the coupling surface is substantially perpendicular to the base plate and coupled to a coupling portion of the machine body.4. The sanding tool of claim 3 , wherein the coupling surface of the battery pack is substantially parallel to the ...

Multi-bit error diffusion

The present invention generally relates to systems and methods for error diffusion, e.g., for use in a halftone process. The described techniques are faster than known techniques in that they utilize fewer computations on average. Consequently, the described techniques can be more readily implemented in software, for example, though the described techniques are not limited to software.

Chemically Activated Nanocapsid Functionalized for Cancer Targeting

Modified capsid proteins containing at least a portion of hepatitis E virus (HEV) open reading frame 2 (ORF2) having one or more cysteine residues in a surface variable loop or the C-terminus of HEV ORF2, or a portion thereof, are provided. The modified capsid proteins can be used to form hepatitis E virus (HEV) virus like particles (VLPs) having cysteine functional groups exposed on the outer-surface. The exposed cysteine functional groups can be modified via their thiol reactive group. For example, a bioactive agent, such as a cell-targeting ligand, can be conjugated to the one or more cysteines for targeted delivery of chemically activated nanocapsids. 2. The modified capsid protein of claim 1 , wherein the HEV ORF2 portion retains its ability to form an acid and proteolytically stable HEV VLP when the surface variable loop or C-terminal cysteine is alkylated claim 1 , agitated claim 1 , arylated claim 1 , succinylated claim 1 , oxidized claim 1 , or conjugated to a detectable label or bioactive agent.3. The modified capsid protein of or claim 1 , wherein the modified capsid protein comprises an amino acid sequence at least 90% claim 1 , 95% claim 1 , or 99% identical claim 1 , or identical claim 1 , to residues 112-608 of the HEV ORF 2 protein of SEQ ID NO:1 claim 1 , 2 claim 1 , 3 claim 1 , 4 claim 1 , 5 claim 1 , or 6.4. The modified capsid protein of or claim 1 , wherein the at least one P-domain surface variable loop or C-terminal cysteine is conjugated to a detectable label.5. The modified capsid protein of claim 4 , wherein the detectable label comprises a fluorophore claim 4 , a superparamagnetic label claim 4 , an MRI contrast agent claim 4 , a positron emitting isotope claim 4 , or a cluster of elements of group 3 through 18 having an atomic number greater than 20.6. The modified capsid protein of claim 5 , wherein the cluster of elements of group 3 through 18 having an atomic number greater than 20 comprises a gold nanocluster.7. The modified capsid ...

PROTEOLYSIS-RESISTANT CAPSID OF CHIMERIC HEPATITIS E VIRUS AS AN ORAL DELIVERY VECTOR

This invention provides a peptide/nucleic acid composition for oral/mucosal, dual-modal activation of immune protection systems. 1. A composition comprising:a modified hepatitis E virus (HEV) capsid protein comprising a portion of HEV ORF 2 protein and a heterologous peptide, wherein the heterologous peptide is inserted into the portion of HEV ORF 2 after residue Tyr485; anda heterologous nucleic acid encapsulated in a chimeric virus-like particle (VLP) formed by the modified HEV capsid protein.2. The composition of claim 1 , wherein the heterologous nucleic acid and the heterologous peptide are from the same source.3. The composition of claim 1 , wherein the heterologous nucleic acid and the heterologous peptide are from different sources.4. The composition of claim 1 , wherein the modified HEV capsid protein comprising a portion of HEV ORF 2 protein and two or more heterologous peptides.5. The composition of claim 1 , wherein the two or more heterologous peptides are from different sources.6. The composition of claim 1 , wherein the two or more heterologous peptides are from the same source.7. The composition of claim 1 , wherein the modified HEV capsid protein comprises residues 112-608 of HEV ORF 2 protein.8. The composition of claim 1 , wherein the heterologous peptide is the p18 epitope of HIV Env gp120 (RIQRGPGRAFVTIGK; SEQ ID NO:9).9. The composition of claim 1 , wherein the modified HEV capsid protein consists of residues 112-608 of HEV ORF 2 protein and p18 inserted after Tyr485.10. A composition of claim 1 , further comprising a pharmaceutically acceptable excipient.11. A composition of claim 10 , wherein the excipient is an adjuvant.12. A composition of claim 10 , wherein the excipient is adapted for oral delivery.13. A composition of claim 10 , wherein the excipient is adapted for mucosal delivery.14. A method of inducing an immunogenic response in a host claim 1 , comprising the step of administering the composition of to the host.15. A modified HEV ...

Charged linkers and their uses for conjugation

Cell binding agent-drug conjugates comprising phosphinate-based charged linkers and methods of using such linkers and conjugates are provided.

VALIDATING SOFTWARE CHARACTERISTICS

Aspects of the subject matter described herein relate to software validation. In aspects, code may be instrumented to generate certain records upon execution. The code may be further instrumented to generate start and stop records that correspond to the start and stop events of a scenario of a program. The start and stop event records allow correlation of the scenario with other records written to the log. With the correlation and appropriate instrumentation, a tool may determine performance, memory usage, functional correctness, and other characteristics of program at the granularity of the scenario. 1. A method implemented at least in part by a computer , the method comprising:obtaining one or more logs generated in conjunction with executing code;within the one or more logs, locating a start event record of a test scenario that is identified by an identifier, the start event record indicating a start timestamp and the identifier of the test scenario;within the one or more logs, locating an stop event record of the test scenario, the stop event record indicating a stop timestamp and the identifier that identifies the test scenario;identifying scenario records included in the one or more logs, the scenario records corresponding to log statements generated after the start event record and before the stop event record; andusing the scenario records to determine statistics regarding the test scenario, the statistics including at least one or more of: performance and memory usage.2. The method of claim 1 , wherein obtaining one or more logs comprises obtaining one or more logs generated by one or more of instrumented: application code claim 1 , runtime code claim 1 , rendering code claim 1 , system code claim 1 , and server code.3. The method of claim 1 , wherein identifying scenario records included in the one or more logs comprises finding records that have a process identifier and a thread identifier associated with the test scenario.4. The method of claim 1 , ...

Microrna initiated dnazyme motor operating in living cells

There is described herein a nanomotor system and methods of use.

Pressure Sensitive Adhesive Laminate for High Performance Noise and Vibration Damping Applications

A pressure sensitive adhesive composition and laminate and having superior adhesive and damping properties is provided. The adhesive laminate includes an acrylic damping composition comprising a graft copolymer having an acrylic backbone and macromonomer side chains.

RORC2 INHIBITORS AND METHODS OF USE THEREOF

The present invention provides compounds, pharmaceutical compositions, methods of inhibiting RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such compounds and pharmaceutical compositions.

NOVEL HETEROCYCLIC COMPOUNDS AS INHIBITORS OF VANIN-1 ENZYME

Compounds, pharmaceutically acceptable salts thereof are disclosed wherein the compounds have the structure of Formula (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed. 2. A compound according to claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein Ris selected from the group consisting of —H claim 1 , —F claim 1 , —CH claim 1 , —CHF claim 1 , —CHF claim 1 , —CF claim 1 , —OCH claim 1 , —OCHF claim 1 , —OCHF claim 1 , and —OCF.3. A compound according to claim 2 , or a pharmaceutically acceptable salt thereof claim 2 , wherein Ris selected from the group consisting of phenyl claim 2 , thiophenyl claim 2 , 1 claim 2 ,4-dioxochromanyl claim 2 , quinolinyl claim 2 , pyrazolyl claim 2 , indazolyl claim 2 , pyridinyl claim 2 , N-methyl-indazolyl and N-methyl-pyrazolyl.4. A compound according to claim 3 , or a pharmaceutically acceptable salt thereof claim 3 , wherein W is selected from the group consisting of —NHCG-Rand —OCG-R.5. A compound according to claim 4 , or a pharmaceutically acceptable salt thereof claim 4 , wherein G is selected form the group consisting of —H; —C-Calkyl claim 4 , for example methyl; —OC-Calkyl; —C-Ccycloalkyl; or two geminal G may claim 4 , together with the carbon to which they are bound claim 4 , form a —C-Ccycloalkylene claim 4 , for example cyclopropylene or cyclobutylene.6. A compound according to selected from the group consisting of:3-[(2-{[1-(pyrimidin-5-yl)cyclopropyl]amino}pyrimidin-5-yl)carbonyl]benzonitrile;3-[(2-{[1-(pyridin-3-yl)cyclopropyl]amino}pyrimidin-5-yl)carbonyl]benzonitrile;3-({2-[(2-phenylpropan-2-yl)amino]pyrimidin-5-yl}carbonyl)benzonitrile;3-[(2-{[(2-amino}pyrimidin-5-yl)methyl]amino)pyrimidin-5-yl)carbonyl]benzonitrile;3-[(2-{[1-(pyrazin-2-yl)cyclopropyl]amino)pyrimidin-5-yl}carbonyl]benzonitrile;3-[(2-{[(6-aminopyridin-3-yl)methyl]amino}pyrimidin-5-yl)carbonyl]benzonitrile;3-[(2-{[1-( ...

Methyl- and Trifluromethyl-Substituted Pyrrolopyridine Modulators of RORC2 and Methods of Use Thereof

The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof. Retinoid-related orphan receptors (ROR) are reported to have an important role in numerous biological processes. Scientific investigations relating to each of retinoid-related orphan receptors RORα, RORβ, and RORγ have been described in the literature. Continuing research in this field is spurred by the promise of developing new therapeutic agents to treat medical disorders associated with retinoid-related orphan receptor activity.RORγ has been reported to be expressed in high concentration in various tissues, such as thymus, kidney, liver, muscle, and certain fat tissue. Two isoforms of RORγ have been identified and are referred to as γ1 and γ2 (also referred to as RORγt). Expression of the γ2 isoform has been reported to appear in, for example, double-positive thymocytes. Compounds capable of modulating RORyt activity are contemplated to provide a therapeutic benefit in the treatment of multiple medical disorders, including immune and inflammatory disorders.Numerous immune and inflammatory disorders continue to afflict millions of patients worldwide. Significant advances have been made in treating these disorders. However, current therapies do not provide satisfactory results for all patients due to, for example, detrimental side effects or insufficient efficacy. Treatments for immune and inflammatory disorders vary depending on the particular medical disorder, and often involve use of immunosuppressive drugs. Surgery (e.g., splenectomy), plasmapheresis, or radiation can be used in certain instances.One exemplary immune disorder in need of better therapy is psoriasis. Psoriasis is a T cell-mediated inflammatory disease that affects ...

Methyl- and Trifluoromethyl-Substituted Pyrrolopyridine Modulators of RORC2 and Methods of Use Thereof

The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof. Retinoid-related orphan receptors (ROR) are reported to have an important role in numerous biological processes. Scientific investigations relating to each of retinoid-related orphan receptors RORα, RORβ, and RORγ have been described in the literature. Continuing research in this field is spurred by the promise of developing new therapeutic agents to treat medical disorders associated with retinoid-related orphan receptor activity.RORγ has been reported to be expressed in high concentration in various tissues, such as thymus, kidney, liver, muscle, and certain fat tissue. Two isoforms of RORγ have been identified and are referred to as γ1 and γ2 (also referred to as RORγt). Expression of the γ2 isoform has been reported to appear in, for example, double-positive thymocytes. Compounds capable of modulating RORyt activity are contemplated to provide a therapeutic benefit in the treatment of multiple medical disorders, including immune and inflammatory disorders.Numerous immune and inflammatory disorders continue to afflict millions of patients worldwide. Significant advances have been made in treating these disorders. However, current therapies do not provide satisfactory results for all patients due to, for example, detrimental side effects or insufficient efficacy. Treatments for immune and inflammatory disorders vary depending on the particular medical disorder, and often involve use of immunosuppressive drugs. Surgery (e.g., splenectomy), plasmapheresis, or radiation can be used in certain instances.One exemplary immune disorder in need of better therapy is psoriasis. Psoriasis is a T cell-mediated inflammatory disease that affects ...

SUBSTITUTED AMINO SIX-MEMBERED NITRIC HETEROCLIC RING COMPOUND AND PREPARATION AND USE THEREOF

Provided in the present invention are a substituted amino six-membered nitric heterocyclic ring compound and a preparation and use thereof. In particular, provided in the present invention is a compound as shown by general formula (I) below, wherein the definition of each group is as described in the description. The compound of the present invention has an excellent tyrosine kinase inhibitory activity, and can thus be used to prepare a series of medicines for treating diseases related to tyrosine kinase inhibitory activity. 2. The compound of claim 1 , wherein claim 1 , in the formula I compound claim 1 , Ris selected from the group consisting of a substituted or unsubstituted C1-C4 alkyl claim 1 , substituted or unsubstituted C1-C4 alkoxy claim 1 , substituted or unsubstituted 5-6 membered heterocyclic group claim 1 , substituted or unsubstituted amino claim 1 , substituted or unsubstituted C1-C4 alkylamino claim 1 , —NHCOR; wherein the substituent group is further substituted by one or more substituents selected from the group consisting of a C1-C8 alkyl claim 1 , hydroxy claim 1 , hydroxy C1-C8 alkyl claim 1 , —COOR claim 1 , amino-substituted C3-C10 cycloalkyl claim 1 , 4-10 membered heterocycloalkyl which is unsubstituted or substituted by one or more halogen atoms claim 1 , hydroxyl or C1-C8 alkyl.3. The compound of claim 1 , wherein claim 1 , in the formula I compound claim 1 , ring A is selected from a substituted or unsubstituted 6-10 membered aryl or substituted or unsubstituted 5-6 membered heteroaryl.4. The compound of claim 1 , wherein claim 1 , in the formula I compound claim 1 , ring A is a substituted or unsubstituted group selected from the group consisting of benzene ring claim 1 , naphthalene ring claim 1 , pyridine ring claim 1 , pyrazine ring claim 1 , thiophene ring claim 1 , furan ring claim 1 , imidazole ring claim 1 , pyrrole ring claim 1 , oxazole ring claim 1 , thiazole ring claim 1 , pyrazole ring claim 1 , indole ring claim 1 , ...

PYRAZOLO[1,5-A]PYRAZIN-4-YL AND RELATED DERIVATIVES

A compound having the structure: 2. The compound of wherein X is C.3. The compound of wherein Ris CN and Ris H.4. The compound of wherein Y is CH or N.5. The compound of wherein Z is N and Z′ is CH.9. The compound of wherein Ris CN and Ris H.12. The compound of selected from the group consisting of:[3-{4-[7-(1H-pyrazol-4-yl)-1,6-naphthyridin-5-yl]-1H-pyrazol-1-yl)-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile;2,2′-(cis-1-{4-[7-(1H-pyrazol-4-yl)-1,6-naphthyridin-5-yl]-1H-pyrazol-1-yl}cyclobutane-1,3-diyl)diacetonitrile;[3-{4-[7-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridin-5-yl]-1H-pyrazol-1-yl)-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile;cis-3-(cyanomethyl)-3-(4-{7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-1,6-naphthyridin-5-yl)-1H-pyrazol-1-yl)cyclobutanecarbonitrile;[3-(4-{7-[1-(oxetan-3-yl)-1H-pyrazol-4-yl]1,6-naphthyridin-5-yl}-1H-pyrazol-1-yl)-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile;[3-(4-{7-[1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-1,6-naphthyridin-5-yl}-1H-pyrazol-1-yl)-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile;[trans-1-(4-{7-[3-(hydroxymethyl)-1H-pyrazol-5-yl]-1,6-naphthyridin-5-yl}-1H-pyrazol-1-yl)-3-methoxycyclobutyl]acetonitrile;[3-{3-[7-(1H-pyrazol-3-yl)-1,6-naphthyridin-5-yl]-1H-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile;[1-(methylsulfonyl)-3-{3-[7-(1H-pyrazol-5-yl)-1,6-naphthyridin-5-yl]-1H-pyrazol-1-yl}azetidin-3-yl]acetonitrile;[1-(cyclopropylsulfonyl)-3-{3-[7-(1H-pyrazol-5-yl)-1,6-naphthyridin-5-yl]-1H-pyrazol-1-yl}azetidin-3-yl]acetonitrile;[1-(oxetan-3-ylsulfonyl)-3-{3-[7-(1H-pyrazol-5-yl)-1,6-naphthyridin-5-yl]-1H-pyrazol-1-yl}azetidin-3-yl]acetonitrile;trans-3-(cyanomethyl)-3-{3-[7-(1H-pyrazol-5-yl)-1,6-naphthyridin-5-yl]-1H-pyrazol-1-yl}cyclobutanecarbonitrile;cis-3-(cyanomethyl)-3-{3-[7-(1H-pyrazol-5-yl)-1,6-naphthyridin-5-yl]-1H-pyrazol-1-yl}cyclobutanecarbonitrile;2,2′-(cis-1-{3-[7-(1H-pyrazol-5-yl)-1,6-naphthyridin-5-yl]-1H-pyrazol-1-yl}cyclobutane-1,3-diyl)diacetonitrile;cis-3-( ...

Bruton's Tyrosine Kinase Inhibitors

Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases cases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions. (Formula I) 210-. (canceled)1213-. (canceled)1528-. (canceled)31. A pharmaceutical composition comprising a compound according to or a pharmaceutically acceptable salt thereof claim 1 , admixed with a pharmaceutically acceptable carrier claim 1 , excipient or dilutent. Signaling through the B-cell receptor (BCR) can lead to a range of biological outputs depending upon, in part, the developmental stage of the B-cell. Faulty signaling through the BCR can cause disregulation of the B-cell function and/or the formation of auto-antibodies which may lead to the auto-immune and/or inflammatory diseases. Therapeutics, such as Rituxan, which deplete B-cells are effective in the treatment of inflammatory diseases such as rheumatoid arthritis. Bruton's Tyrosine Kinase (BTK) is a member of the TEC family of kinases and is a regulator of B-cell development, activation, signaling and survival. BTK is downstream of the BCR. In humans, mutation of BTK causes X-linked agammaglobulinemia results in a compromised immune system, impaired maturation of B-cells, decreased peripheral B-cell levels and reduced calcium mobilization following stimulation through the BCR. Further evidence for the role of BTK in autoimmune and inflammatory diseases has been established utilizing both BTK knock-out mouse models and pharmacological inhibitors. In addition to to B-cells, BTK is expressed on several other cell types that may contribute to disease, for example: mast cells, basophils, neutrophils, monocytes ...

NOVEL USE OF FIBROBLAST GROWTH FACTOR 2

The present invention provides a novel use of fibroblast growth factor 2 (FGF-2), i.e., a use of FGF-2 in preparation of medicine. The uses of the medicine are the following (a) and/or (b) and/or (c): (a) the prevention and/or treatment of lung injury; (b) the prevention and/or treatment of influenza; (c) the prevention and/or treatment of diseases caused by influenza viruses. 120-. (canceled)21. A method of protecting a mammal from a lung injury , an influenza or a disease induced by an influenza virus or treating a lung injury , an influenza or a disease induced by an influenza virus in a mammal , said mammal being in need of said protecting or treating , said method comprising administering FGF-2 to said mammal.22. The method according to claim 21 , wherein the FGF-2 is a human-derived FGF-2.23. The method according to claim 22 , wherein the FGF-2 is:(A) a protein as set forth by SEQ ID NO. 1 in the Sequence Listing; or(B) a protein derived from (A) with a substitution and/or a deletion and/or an addition of one or more amino acid residues and having the same activity as (A).24. The method according to claim 21 , wherein the mammal is in need of the protecting or treating for a lung injury.25. The method according to claim 24 , wherein the lung injury is a lung injury induced by a virus claim 24 , a bacterium or a fungus.26. The method according to claim 24 , wherein the lung injury is a lung injury induced by septicemia.27. The method according to claim 21 , wherein the mammal is in need of the treating for influenza claim 21 , or the protecting or the treating for a disease induced by an influenza virus.28. The method according to claim 27 , wherein the influenza virus is influenza A virus H1N1. The present invention relates to a novel use of fibroblast growth factor 2.The family of fibroblast growth factors (FGFs) includes 23 polymorphic growth factors with associated structures. Fibroblast growth factor-2 (FGF-2), which is one of the members of the FGF family ...

Method and apparatus for finer control in thin line growth

A method, non-transitory computer readable medium, and apparatus for providing controlling a thin line growth are disclosed. For example, the method receives an image in a first resolution, wherein each pixel of a plurality of pixels within the image is marked with a first tag and a second tag, wherein the first tag determines whether each pixel is on or off in the image and the second tag determines whether a thin line growth for each pixel is on or off in the image and produces a second image in a second resolution based upon the image in the first resolution, wherein the thin line is grown by turning on each pixel in a sub-line that is adjacent to a different pixel from a different sub-line having the first tag on and the second tag of the each pixel in the sub-line is on.

Methyl- and Trifluoromethyl-Substituted Pyrrolopyridine Modulators of RORC2 and Methods of Use Thereof

The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof. 1. (R)-3-Cyano-N-(3-(1-(cyclopentanecarbonyl)-2 ,2 dimethylpiperidin-4-yl)-1 ,4-dimethyl-1H-pyrrolo[2 ,3-b]pyridin-5-yl)benzamide or a pharmaceutically acceptable salt thereof.3. A pharmaceutical composition comprising (R)-3-cyano-N-(3-(1-(cyclopentanecarbonyl)-2 ,2 dimethylpiperidin-4-yl)-1 ,4-dimethyl-1H-pyrrolo[2 ,3-b]pyridin-5-yl)benzamide , or a pharmaceutically acceptable salt thereof , and at least one pharmaceutically acceptable carrier , excipient , or diluent.4. A method of treating psoriasis in a patient comprising administering to the patient in need of such treatment a therapeutically effective amount of (R)-3-cyano-N-(3-(1-(cyclopentanecarbonyl)-2 ,2 dimethylpiperidin-4-yl)-1 ,4-dimethyl-1H-pyrrolo[2 ,3-b]pyridin-5-yl)benzamide , or a pharmaceutically acceptable salt thereof ,5. A method of treating psoriasis in a patient comprising administering to the patient in need of such treatment a pharmaceutical composition comprising a therapeutically effective amount of (R)-3-cyano-N-(3-(1-(cyclopentanecarbonyl)-2 ,2 dimethylpiperidin-4-yl)-1 ,4-dimethyl-1H-pyrrolo[2 ,3-b]pyridin-5-yl)benzamide , or a pharmaceutically acceptable salt thereof , and at least one pharmaceutically acceptable carrier , excipient , or diluent. Retinoid-related orphan receptors (ROR) are reported to have an important role in numerous biological processes. Scientific investigations relating to each of retinoid-related orphan receptors RORα, RORβ, and RORγ have been described in the literature. Continuing research in this field is spurred by the promise of developing new therapeutic agents to treat medical disorders associated with retinoid-related orphan ...

AMINOPYRIMIDINYL COMPOUNDS

A compound having the structure: 121-. (canceled)2529-. (canceled)32. (canceled)33. A method for treating inflammatory bowel disease or ulcerative colitis , comprising administering to a subject suffering therefrom a therapeutically effective amount of a compound selected from the group consisting of:[(1S)-2,2-difluorocyclo-propyl]{(1R,5S)-3-[2-(1H-pyrazol-4-ylamino)pyrimidin-4-yl]-3,8-diazabi-cyclo[3.2.1]oct-8-yl}methanone;[(1S)-2,2-difluorocyclo-propyl][(1R,5S)-3-{2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}-3,8-diazabicyclo[3.2.1]oct-8-yl]methanone; and,[(1R)-2,2-difluorocyclo-propyl][(1R,5S)-3-{2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}-3,8-diazabicyclo[3.2.1]oct-8-yl]methanone; or, a pharmaceutically acceptable salt thereof.34. A method for treating psoriasis , comprising administering to a subject suffering therefrom a therapeutically effective amount of a compound selected from the group consisting of:[(1S)-2,2-difluorocyclo-propyl]{(1R,5S)-3-[2-(1H-pyrazol-4-ylamino)pyrimidin-4-yl]-3,8-diazabi-cyclo[3.2.1]oct-8-yl}methanone;[(1S)-2,2-difluorocyclo-propyl][(1R,5S)-3-{2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}-3,8-diazabicyclo[3.2.1]oct-8-yl]methanone; and,[(1R)-2,2-difluorocyclo-propyl][(1R,5S)-3-{2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}-3,8-diazabicyclo[3.2.1]oct-8-yl]methanone; or, a pharmaceutically acceptable salt thereof.35. A method for treating alopecia , comprising administering to a subject suffering therefrom a therapeutically effective amount of a compound selected from the group consisting of:[(1S)-2,2-difluorocyclo-propyl]{(1R,5S)-3-[2-(1H-pyrazol-4-ylamino)pyrimidin-4-yl]-3,8-diazabi-cyclo[3.2.1]oct-8-yl}methanone;[(1S)-2,2-difluorocyclo-propyl][(1R,5S)-3-{2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}-3,8-diazabicyclo[3.2.1]oct-8-yl]methanone; and,[(1R)-2,2-difluorocyclo-propyl][(1R,5S)-3-{2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}-3,8-diazabicyclo[3.2.1]oct-8-yl]methanone; or, a pharmaceutically ...

Sulfonamide-Substituted Indole Modulators of RORC2 and Methods of Use Thereof

The present invention provides sulfonamide-substituted indoles and Methods of Use Thereof-substituted pyrro-lopyridines, pharmaceutical compositions thereof methods of modulating RORy activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such indoles and pharmaceutical compositions thereof. 2. The compound of claim 1 , wherein Ris —CH.5. (canceled)1011-. (canceled)12. The compound of claim 9 , wherein Ris (C-C)alkyl.1315-. (canceled)16. The compound of claim 9 , wherein Ris unsubstituted (C-C)cycloalkyl.1718-. (canceled)21. A pharmaceutical composition comprising a compound according to claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , admixed with a pharmaceutically acceptable carrier claim 1 , excipient or dilutent.22. (canceled)23. A method for treating an immune disorder or inflammatory disorder in a subject comprising administering to the subject in need of such treatment a therapeutically effective amount of a compound of or a pharmaceutically acceptable salt thereof.24. The method of claim 23 , wherein the disorder is an inflammatory disorder.25. The method of claim 23 , wherein the disorder is an autoimmune disorder.26. The method of claim 23 , wherein the disorder is rheumatoid arthritis claim 23 , psoriasis claim 23 , chronic graft-versus-host disease claim 23 , acute graft-versus-host disease claim 23 , Crohn's disease claim 23 , inflammatory bowel disease claim 23 , multiple sclerosis claim 23 , systemic lupus erythematosus claim 23 , Celiac Sprue claim 23 , idiopathic thrombocytopenic thrombotic purpura claim 23 , myasthenia gravis claim 23 , Sjogren's syndrome claim 23 , scleroderma claim 23 , ulcerative colitis claim 23 , asthma claim 23 , epidermal hyperplasia claim 23 , cartilage inflammation claim 23 , bone degradation claim 23 , arthritis claim 23 , juvenile arthritis claim 23 , juvenile rheumatoid arthritis claim 23 , pauciarticular juvenile rheumatoid arthritis claim 23 ...

Autonomous Cleaning Robot

The present disclosure relates to a liquid container and an autonomous cleaning robot. The liquid container may include a container case and a cleaning cloth that is removable and mounted on the container case. The cleaning cloth may include a first guiding member disposed thereon. The container case may include a second guiding member. The first guiding member and the second guiding member cooperate with each other to define an assembly direction of the cleaning cloth. The cleaning cloth can be installed correctly by defining the assembly direction of the first guiding member and the second guiding member.

Bruton's Tyrosine Kinase Inhibitors

Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions. 2. The compound of claim 1 , wherein R is cyano or cyano(C-C)alkyl.6. (canceled)7. The compound of claim 1 , wherein X is O claim 1 , CHor C(═O).8. The compound of claim 1 , wherein X is O.9. The compound of claim 1 , wherein X is CH.10. The compound of claim 1 , wherein W is phenyl optionally substituted with one claim 1 , two claim 1 , three claim 1 , four or five Rindependently selected for each occurrence from the group consisting of (C-C)alkyl claim 1 , halo(C-C)alkyl claim 1 , (C-C)alkoxy claim 1 , and halo.12. The compound of claim 1 , wherein W is pyridyl optionally substituted with one claim 1 , two claim 1 , three claim 1 , or four Rindependently selected from the group consisting of (C-C)alkyl claim 1 , halo(C-C)alkyl claim 1 , halo claim 1 , hydroxy claim 1 , hydroxy(C)alkyl claim 1 , (C-C)alkoxy claim 1 , and (C-C)haloalkoxy.21. A pharmaceutical composition comprising a compound according to claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , admixed with a pharmaceutically acceptable carrier claim 1 , excipient or dilutent.22. (canceled)23. A method for treating an autoimmune disease claim 21 , a heteroimmune condition or disease claim 21 , an inflammatory disease claim 21 , or a cancer comprising administering to a subject in need thereof a pharmaceutical composition of .24. (canceled)25. (canceled)26. (canceled)27. (canceled)28. (canceled) Signaling through the B-cell receptor (BCR) can lead to a range of biological outputs depending upon, in part, ...

Bruton's Tyrosine Kinase Inhibitors

Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseeases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions. 2. The compound of claim 1 , wherein R is cyano or cyano(C-C)alkyl.6. (canceled)7. The compound of claim 1 , wherein X is O claim 1 , CHor C(═O).8. The compound of claim 1 , wherein X is O.9. The compound of claim 1 , wherein X is CH.10. The compound of claim 1 , wherein W is phenyl optionally substituted with one claim 1 , two claim 1 , three claim 1 , four or five Rindependently selected for each occurrence from the group consisting of (C-C)alkyl claim 1 , halo(C-C)alkyl claim 1 , (C-C)alkoxy claim 1 , and halo.12. The compound of claim 1 , wherein W is pyridiyl optionally substituted with one claim 1 , two claim 1 , three claim 1 , or four Rindependently selected from the group consisting of (C-C)alkyl claim 1 , halo(C-C)alkyl claim 1 , halo claim 1 , hydroxy claim 1 , hydroxy(C-)alkyl claim 1 , (C-C)alkoxy claim 1 , and (C-C)haloalkoxy.21. A pharmaceutical composition comprising a compound according to claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , admixed with a pharmaceutically acceptable carrier claim 1 , excipient or dilutant.22. (canceled)23. A method for treating an autoimmune disease claim 21 , a heteroimmune condition or disease claim 21 , an inflammatory disease claim 21 , or a cancer comprising administering to a subject in need thereof a pharmaceutical composition of .24. (canceled)25. (canceled)26. (canceled)27. (canceled)28. (canceled) Signaling through the B-cell receptor (BCR) can lead to a range of biological outputs depending upon, in part ...

RORC2 INHIBITORS AND METHODS OF USE THEREOF

The present invention provides compounds, pharmaceutical compositions, methods of inhibiting RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such compounds and pharmaceutical compositions. 2. The compound of claim 1 , wherein Ris methyl.3. The compound of claim 2 , wherein Y is hydrogen or methyl.11. A pharmaceutical composition comprising a compound according to claim 1 , or a pharmaceutically acceptable salt claim 1 , or pharmaceutically acceptable solvate thereof claim 1 , admixed with a pharmaceutically acceptable carrier claim 1 , excipient or diluent.12. A method for treating an immune disorder or inflammatory disorder comprising administering to a subject in need thereof a pharmaceutical composition of .13. The method of claim 12 , wherein the disorder is an inflammatory disorder.14. The method of claim 12 , wherein the disorder is an autoimmune disorder.15. The method of claim 12 , wherein the disorder is rheumatoid arthritis claim 12 , psoriasis claim 12 , chronic graft-versus-host disease claim 12 , acute graft-versus-host disease claim 12 , Crohn's disease claim 12 , inflammatory bowel disease claim 12 , multiple sclerosis claim 12 , systemic lupus erythematosus claim 12 , Celiac Sprue claim 12 , idiopathic thrombocytopenic thrombotic purpura claim 12 , myasthenia gravis claim 12 , Sjogren's syndrome claim 12 , scleroderma claim 12 , ulcerative colitis claim 12 , asthma claim 12 , epidermal hyperplasia claim 12 , cartilage inflammation claim 12 , bone degradation claim 12 , arthritis claim 12 , juvenile arthritis claim 12 , juvenile rheumatoid arthritis claim 12 , pauciarticular juvenile rheumatoid arthritis claim 12 , polyarticular juvenile rheumatoid arthritis claim 12 , systemic onset juvenile rheumatoid arthritis claim 12 , juvenile ankylosing spondylitis claim 12 , juvenile enteropathic arthritis claim 12 , juvenile Reter's Syndrome claim 12 , SEA Syndrome claim 12 , juvenile ...

NOVEL HETEROCYCLIC COMPOUNDS AS INHIBITORS OF VANIN-1 ENZYME

Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of 2. The method according to wherein Ris selected from the group consisting of —H claim 1 , —F claim 1 , —CH claim 1 , —CHF claim 1 , —CHF claim 1 , —CF claim 1 , —OCH claim 1 , —OCHF claim 1 , —OCHF claim 1 , and —OCF.3. The method according to wherein Ris selected from the group consisting of phenyl claim 2 , thiophenyl claim 2 , 1 claim 2 ,4-dioxochromanyl claim 2 , quinolinyl claim 2 , pyrazolyl claim 2 , indazolyl claim 2 , pyridinyl claim 2 , N-methyl-indazolyl and N-methyl-pyrazolyl.4. The method according to wherein W is selected from the group consisting of{'sub': 2', '2, 'sup': 2', '2, '—NHCG-Rand —OCG-R.'}5. The method according to wherein G is selected from the group consisting of —H; —C-Calkyl; methyl; —OC-Calkyl; —C-Ccycloalkyl; or two geminal G may claim 4 , together with the carbon to which they are bound claim 4 , form a —C-Ccycloalkylene claim 4 , for example cyclopropylene or cyclobutylene.6. The method according to wherein the compound of Formula I is selected from the group consisting of:3-[(2-{[1-(pyrimidin-5-yl)cyclopropyl]amino}pyrimidin-5-yl)carbonyl]benzonitrile;3-[(2-{[1-(pyridin-3-yl)cyclopropyl]amino}pyrimidin-5-yl)carbonyl]benzonitrile;3-({2-[(2-phenylpropan-2-yl)amino]pyrimidin-5-yl}carbonyl)benzonitrile;3-[(2-{[(2-aminopyrimidin-5-yl)methyl]amino}pyrimidin-5-yl)carbonyl]benzonitrile;3-[(2-{[1-(pyrazin-2-yl)cyclopropyl]amino}pyrimidin-5-yl)carbonyl]benzonitrile;3-[(2-{[(6-aminopyridin-3-yl)methyl]amino}pyrimidin-5-yl)carbonyl]benzonitrile;3-[(2-{[1-(pyridin-3-yl)ethyl]amino}pyrimidin-5-yl)carbonyl]benzonitrile;4-(1-{[5-(3-cyanobenzoyl)pyrimidin-2-yl]amino}ethyl)benzamide;(−)-4-(1-{[5-(3-cyanobenzoyl)pyrimidin-2-yl]amino}ethyl)benzamide;(+)-4-(1-{[5-(3-cyanobenzoyl)pyrimidin-2-yl]amino}ethyl)benzamide;{2-[(pyrazin-2-ylmethyl)amino]pyrimidin-5-yl}[3-(trifluoromethyl)phenyl]methanone;{2-[(pyridin-3-ylmethyl)amino]pyrimidin-5-yl}[3 ...

DNA Polymerase IIIC Inhibitors and Use Thereof

The present invention relates to compounds and methods useful for inhibiting the DNA polymerase IIIC enzyme. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of Gram-positive bacterial infections. 2. A compound as in claim 1 ,wherein A and B are N;wherein n is 1;{'sub': 1', '2', 'm', 'o', '2', 'p', 'q, 'wherein Ris (CH)—{(V)—(CH)}—W;'}{'sub': '2', 'wherein V is CH, CO, O, OC(O), or (O)CO,'}{'sub': 2', '10, 'wherein W is H, halo, substituted or unsubstituted C1-6 alkyl, NH, CN, or OR,'}{'sub': 10', '1-6, 'wherein Ris H or substituted or unsubstituted Calkyl,'}in which m is 1-5, o is 0-4, p is 0-4, and q is 0-4;{'sub': '2', 'wherein Ris H, CN, F, or Cl;'}{'sub': '3', 'wherein Ris a 3- or 4-F, Cl, Me, or ethyl substituted phenyl group, a 3,4-dichloro, 3,4-difluoro, 3-Me-4-Cl, 3-Me-4-F, 3-Cl-4-Me, 3-F-4-Me, 3-ethyl-4-Cl, 3-ethyl-4-F, 3-Cl-4-ethyl, or 3-F-4-ethyl substituted phenyl group; a benzo[d][1,3]dioxole group; a 2,2-dimethylbenzo[d]-[1,3]dioxole group; or a 2,2-difluorobenzo[d][1,3]dioxole group;'}{'sub': '0', 'wherein Ris H,'}or an optical isomer thereof, an isotopic isomer thereof, a prodrug or a pharmaceutically acceptable salt thereof.3. A compound as in claim 2 ,wherein A and B are N;wherein n is 1;{'sub': 1', '2', 'm', 'o', '2', 'p', 'q, 'wherein Ris (CH)—{(V)—(CH)}—W;'}wherein V is CO, O, OC(O), or (O)CO,{'sub': 2', '10, 'wherein W is H, halo, NH, CN, or OR,'}{'sub': 10', '1-6, 'wherein Ris H or substituted or unsubstituted Calkyl,'}in which m is 1-5, o is 0-1, p is 0-4, and q is 0-4;{'sub': '2', 'wherein Ris H, CN, F, or Cl;'}{'sub': '3', 'wherein Ris a 3- or 4-F, Cl, Me, or ethyl substituted phenyl group; a 3,4-dichloro, 3,4-difluoro, 3-Me-4-Cl, 3-Me-4-F, 3-Cl-4-Me, 3-F-4-Me, 3-ethyl-4-Cl, 3-ethyl-4-F, 3-Cl-4-ethyl, or 3-F-4-ethyl substituted phenyl group; a benzo[d][1,3]dioxole group; a 2,2-dimethylbenzo[d]-[1,3]dioxole group; or a 2 ...

DNA Polymerase IIIC Inhibitors and Use Thereof

The present invention relates to compounds and methods useful for inhibiting the DNA polymerase IIIC enzyme. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of Gram-positive bacterial infections. 28.-. (canceled)9. The method of claim 1 , wherein said surface is a surface of a medical device.11. (canceled)12. A method of inhibiting the growth of Gram-positive bacteria claim 1 , said method comprising contacting a medium with an effective amount of a compound selected from the group consisting of:5-((3,4-Dichlorobenzyl)amino)-1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one,5-((3,4-Dichlorobenzyl)amino)-3-fluoro-1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one,1-Allyl-5-((3,4-dichlorobenzyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one,4-(5-((3,4-Dichlorobenzyl)amino)-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-1-yl)butyl acetate,1-(Cyclobutylmethyl)-5-((3,4-dichlorobenzyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one,5-[(3,4-Cichlorophenyl)methylamino]-1-phenyl-6H-pyrazolo[4,3-d]pyrimidin-7-one,1-Cyclopropyl-5-((3,4-dichlorobenzyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one,Cyclopentyl-5-((3,4-dichlorobenzyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one,Cethyl 5-(5-chloro-7-methoxy-pyrazolo[4,3-d]pyrimidin-1-yl) pentanoate,5-[(3,4-Cichlorophenyl)methylamino]-1-(4-pyridyl)-6H-pyrazolo[4,3-d]pyrimidin-7-one,3-Chloro-5-((3,4-dichlorobenzyl)amino)-1-(2-methoxyethyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one,5-((3,4-Cichlorobenzyl)amino)-3-fluoro-1-(2-methoxyethyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one,3-Chloro-5-((3,4-dichlorobenzyl)amino)-1-(oxazol-4-ylmethyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one,1-(2-(4-Acetylpiperazin-1-yl)ethyl)-5-((3,4-dichlorobenzyl)amino)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one hydrochloride,5-((3,4-Dichlorobenzyl)amino)-1-(2-(2-hydroxyethoxy)ethyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one,5-((3,4-Dichlorobenzyl)amino)-1-(2-methoxyethyl ...

Packaging Box for an Electronic Device

The invention discloses a packaging box for an electronic device, wherein an opening is formed in one surface of a box body of the packaging box, and a detachable cover plate is mounted on the opening; the remaining part of the box body is composed of box plates with an integrated groove-shaped structure; the electronic device is placed in the box body, and an input-output and control module connected with the electronic device is arranged on the cover plate. According to the packaging box for an electronic device disclosed by the invention, by arranging the detachable cover plate on the opening in the one surface of the box body of the packaging box, and forming the remaining part into the integrated groove-shaped structure, the box body has better overall sealing performance, and moreover, disassembling one cover plate can reduce the workload of disassembly and assembly.

Method and Device for Generating Clinical Research Report

A method and device for generating a clinical research report are provided. The method includes: obtaining a target text and an initial template of a target clinical research report, where the target text includes a target title and a body corresponding to the target title, the initial template includes a preset title and a body part to be filled corresponding to the preset title; matching the preset title with the target title, and copying a body corresponding to the matched target title into the body part to be filled corresponding to the preset title in the initial template, to generate a target template of the target clinical research report, in a case that the matching is successful; and generating the target clinical research report based on the target template.

AMINOPYRIMIDINYL COMPOUNDS

A compound compound having the structure: 143-. (canceled)45. The compound of claim 44 , wherein A is C═O claim 44 , or a pharmaceutically acceptable salt thereof.46. The compound of claim 44 , wherein j is 0 claim 44 , or a pharmaceutically acceptable salt thereof.47. The compound of claim 44 , wherein Ris monocyclic heteroaryl and said monocyclic heteroaryl is pyrazole claim 44 , or a pharmaceutically acceptable salt thereof.48. The compound of claim 47 , wherein said monocyclic heteroaryl is pyrazole substituted by C-Calkyl claim 47 , or a pharmaceutically acceptable salt thereof.52. A pharmaceutical composition comprising a compound of to claim 47 , or a pharmaceutically acceptable salt thereof claim 47 , and a pharmaceutically acceptable carrier.53. A method of treating or preventing a disease or condition for which a JAK1 inhibitor is indicated claim 47 , in a subject in need of such treatment claim 47 , comprising administering to the subject a therapeutically effective amount of a compound of to claim 47 , or a pharmaceutically acceptable salt thereof.54. A method of treating or preventing an inflammatory or autoimmune condition comprising administering to a subject in need thereof a therapeutically effective amount of a compound of to claim 47 , or a pharmaceutically acceptable salt thereof.55. A method of treating or preventing a disease or condition selected from inflammation claim 47 , autoimmune disease claim 47 , neuroinflammation claim 47 , arthritis claim 47 , rheumatoid arthritis claim 47 , spondyloarthropathies claim 47 , systemic lupus erythematous claim 47 , lupus nephritis claim 47 , osteoarthritis claim 47 , gouty arthritis claim 47 , pain claim 47 , fever claim 47 , pulmonary sarcoidosis claim 47 , silicosis claim 47 , cardiovascular disease claim 47 , atherosclerosis claim 47 , myocardial infarction claim 47 , thrombosis claim 47 , congestive heart failure and cardiac reperfusion injury claim 47 , cardiomyopathy claim 47 , stroke claim 47 , ...

Convolution neural network based landmark tracker

There are provided systems and methods for facial landmark detection using a convolutional neural network (CNN). The CNN comprises a first stage and a second stage where the first stage produces initial heat maps for the landmarks and initial respective locations for the landmarks. The second stage processes the heat maps and performs Region of Interest-based pooling while preserving feature alignment to produce cropped features. Finally, the second stage predicts from the cropped features a respective refinement location offset to each respective initial location. Combining each respective initial location with its respective refinement location offset provides a respective final coordinate (x,y) for each respective landmark in the image. Two-stage localization design helps to achieve fine-level alignment while remaining computationally efficient. The resulting architecture is both small enough in size and inference time to be suitable for real-time web applications such as product simulation and virtual reality.

Methyl- and Trifluromethyl-Substituted Pyrrolopyridine Modulators of RORC2 and Methods of Use Thereof

The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof. 1. 3-cyano-N-(3-((3R ,4R)-1-isobutyryl-3-methylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrrolo[2 ,3-b]pyridin-5-yl)benzamide or a pharmaceutically acceptable salt thereof.3. A pharmaceutical composition comprising 3-cyano-N-(3-((3R ,4R)-1-isobutyryl-3-methylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrrolo[2 ,3-b]pyridin-5-yl)benzamide , or a pharmaceutically acceptable salt thereof , and at least one pharmaceutically acceptable carrier , excipient , or diluent.4. A method of treating a disorder in a patient comprising administering to the patient in need of such treatment a therapeutically effective amount of 3-cyano-N-(3-((3R ,4R)-1-isobutyryl-3-methylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrrolo[2 ,3-b]pyridin-5-yl)benzamide , or a pharmaceutically acceptable salt thereof , wherein the disorder is selected from the group consisting of inflammatory bowel disease , ulcerative colitis , and Crohn's disease.5. A method of treating a disorder in a patient comprising administering to the patient in need of such treatment a pharmaceutical composition comprising a therapeutically effective amount of 3-cyano-N-(3-((3R ,4R)-1-isobutyryl-3-methylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrrolo[2 ,3-b]pyridin-5-yl)benzamide , or a pharmaceutically acceptable salt thereof , and at least one pharmaceutically acceptable carrier , excipient , or diluent , wherein the disorder is selected from the group consisting of inflammatory bowel disease , ulcerative colitis , and Crohn's disease. Retinoid-related orphan receptors (ROR) are reported to have an important role in numerous biological processes. Scientific investigations ...

Gas turbine engine airfoil

A compressor may include an airfoil configured to rotate about an axis. The airfoil may have a span measured radially from a root of the airfoil to a tip of the airfoil. A compressor case may be radially adjacent to the airfoil. The airfoil and the compressor case may define a clearance between the tip of the airfoil and a radially inner surface of the compressor case. A ratio of the clearance to the span may be 2.5 percent or less. A mass flow rate of the compressor may be 3.0 pounds-mass per second or less.

PYRAZOLO[1,5-A]PYRAZIN-4-YL DERIVATIVES

A compound having the structure: 151-. (canceled)53. The method of claim 52 , wherein R″ is C-Calkyl.54. The method of claim 52 , wherein R″ is C-Calkyl and Ris H.55. The method of claim 52 , wherein the compound is (1r claim 52 ,3r)-3-(cyanomethyl)-3-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1 claim 52 ,5-a]pyrazin-4-yl)-1H-pyrazol-1-yl)cyclobutane-1-carbonitrile claim 52 , or a pharmaceutically acceptable salt thereof.56. A method of treating a psoriasis comprising administering to a subject suffering therefrom a therapeutically effective amount of the compound (1r claim 52 ,3r)-3-(cyanomethyl)-3-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1 claim 52 ,5-a]pyrazin-4-yl)-1H-pyrazol-1-yl)cyclobutane-1-carbonitrile claim 52 , or a pharmaceutically acceptable salt thereof.58. The method of claim 57 , wherein R″ is C-Calkyl.59. The method of claim 57 , wherein R″ is C-Calkyl and Ris H.60. The method of claim 57 , wherein the compound is (1r claim 57 ,3r)-3-(cyanomethyl)-3-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1 claim 57 ,5-a]pyrazin-4-yl)-1H-pyrazol-1-yl)cyclobutane-1-carbonitrile claim 57 , or a pharmaceutically acceptable salt thereof.61. A method of treating inflammatory bowel disease comprising administering to a subject suffering therefrom a therapeutically effective amount of the compound (1r claim 57 ,3r)-3-(cyanomethyl)-3-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1 claim 57 ,5-a]pyrazin-4-yl)-1H-pyrazol-1-yl)cyclobutane-1-carbonitrile claim 57 , or a pharmaceutically acceptable salt thereof.63. The method of claim 62 , wherein R″ is C-Calkyl.64. The method of claim 62 , wherein R″ is C-Calkyl and Ris H.65. The method of claim 62 , wherein the compound is (1r claim 62 ,3r)-3-(cyanomethyl)-3-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1 claim 62 ,5-a]pyrazin-4-yl)-1H-pyrazol-1-yl)cyclobutane-1-carbonitrile claim 62 , or a pharmaceutically acceptable salt thereof.66. A method of treating ulcerative colitis comprising administering to a subject suffering therefrom a ...

Charged linkers and their uses for conjugation

Cell binding agent-drug conjugates comprising phosphinate-based charged linkers and methods of using such linkers and conjugates are provided.

Charged linkers and their uses for conjugation

Cell binding agent-drug conjugates comprising phosphinate-based charged linkers and methods of using such linkers and conjugates are provided.

Charged linkers and their uses for conjugation

Cell binding agent-drug conjugates comprising phosphinate-based charged linkers and methods of using such linkers and conjugates are provided.

Aptamers selected against live S. pyogenes cells

The invention is directed to aptamers, methods and kits comprising same for detecting Streptococcus pyogenes . The method of screening a subject for Streptococcus pyogenes involves obtaining a body sample from the subject; contacting the sample or a bacterial culture of the sample with an aptamer or a panel of aptamers specific to S. pyogenes ; and detecting the presence or absence of S. pyogenes in the sample or the bacterial culture, wherein binding of the aptamer is indicative of the presence of S. pyogenes.

Auristatin analogues and their conjugates with cell-binding molecules

This invention relates to analogues of auristatins, in particular monomethyl auristatin F (MMAF), as cytotoxic agents, conjugates of such cytotoxic agents with a cell-binding agent, the preparation and the therapeutic uses of these cytotoxic agents and conjugates thereof to arrest or retard abnormal cell growth and /or proliferation.

Full-span forward swept airfoils for gas turbine engines

Rotor of a gas turbine engines having a rotor hub and a plurality of blades extending from the rotor hub, wherein each blade has a full-span forward sweep along a leading edge of the blade that starts at an airfoil root of the blade at the hub and extends to a blade tip, wherein a sweep of a blade is a percentage of a root axial chord length of the respective blade.

Auristatin analogues and their conjugates with cell-binding molecules

Provided are analogues of auristatins, in particular monomethyl auristatin F (MMAF), as cytotoxic agents, conjugates of such agents with a cell-binding agent, the preparation and the therapeutic uses of these cytotoxic agents and conjugates thereof to arrest or retard abnormal cell growth and /or proliferation.

Sealing connector

A self-tightening sealing connector includes a first tubular member, a second tubular member, a first locking member, and a first sealing member. The first tubular member includes a first connecting end and a first flange located at the first connecting end. The second tubular member includes a second connecting end. The second connecting end is configured to be connected with the first connecting end thereby fluid communicating the first tubular member with the second tubular member. The first sealing member is configured to be located between the first locking member and the first flange. In an assembled state, the first locking member and the first flange is capable of applying a force on the first sealing member in an axial direction, and the force can be increased, when an inner fluid pressure is increased.

Improved vessel anastomosis clips and related methods of use

A surgical instrument system for anastomosis of first vessel and second vessel, the surgical instrument including an actuator assembly having distal and proximal ends, a head, and a clip seat, the head and clip seat being detachably mounted to the distal end of the actuator assembly. This device enables anastomosis to be with one action of squeeze with reduced risk of thrombosis, stenosis and time of operation. A surgical instrument of the present invention has the capability to be used in minimally invasive surgery when anastomosis is required through a small surgical excision. Anastomosis capable with embodiments of the present invention include, but are not limited to, end-to-end and end-to-side connections.

DERIVATIVES OF PIRAZOLO [1,5-A] PIRAZIN-4-ILO

Un compuesto que tiene la siguiente estructura o una sal de este aceptable desde el punto de vista farmacéutico, o un solvato aceptable desde el punto de vista farmacéutico de un compuesto o una sal aceptable desde el punto de vista farmacéutico, en donde A, A¿ y A¿¿ son independientemente O, C=O, C-R¿ o N-R¿¿, en donde R¿ y R¿¿ pueden ser independientemente H, amino, -NR7COR6, COR6, -CONR7R8, C1-C6 alquilo o hidroxi(C1-C6 alquilo), y R¿¿ puede estar presente o ausente, y está presente donde las reglas de valencia lo permiten, y en donde no más de uno de A, A¿ y A¿¿ es O o C=O; R0 y R son independientemente H, Br, Cl, F o C1-C6 alquilo; R1 es H, C1-C6 alquilo o hidroxi(C1-C6 alquilo); R2 se selecciona del grupo que consiste en H, C1-C6 alquilo, C1-C6 alcoxi, hidroxi(C1-C6 alquilo), fenil(C1-C6 alquilo), formilo, heteroarilo, heterocíclico, -COR6, -OCOR6, -COOR6, -NR7COR6, -CONR7R8 y -(CH2)n-W, en donde W es ciano, hidroxi, C3-C8 cicloalquilo, -SO2NR7R8 y -SO2-R9, en donde R9 es C1-C6 alquilo, C3-C8 cicloalquilo, heteroarilo o heterocíclico; en donde cada uno de alquilo, cicloalquilo, heterocíclico o heteroarilo puede ser no sustituido o sustituido por halo, ciano, hidroxi o C1-C6 alquilo; X es C-R3 o N, en donde R3 puede ser H o C1-C6 alquilo; R4 y R5 son independientemente H, amino, C1-C6 alquilo o hidroxi(C1-C6 alquilo); R6, R7 y R8 son, cada uno independientemente, H, C1-C6 alquilo, C1-C4 alcoxi(C1-C6 alquilo) o C3-C8 cicloalquilo, dicho C1-C6 alquilo se sustituye opcionalmente con halo, CN o hidroxi; o R7 y R8, junto con el átomo unido a estos, forman un anillo de 5 o 6 miembros, en donde el anillo se sustituye opcionalmente con halo, hidroxi, CN o C1-C6 alquilo; y n es 0, 1, 2 o 3. También se proporcionan métodos de tratamiento tales como inhibidores de quinasas Janus y composiciones farmacéuticas que contienen los compuestos de la invención y combinaciones de estos con otros agentes terapéuticos.

System for distinguishing line patterns from halftone screens in image data

In a system, such as in a digital copier, for classifying image data derived from an original image, the image data is classified by type. An algorithm is applied to the gray levels of pixels surrounding each pixel of interest. The algorithm determines whether a local maximum or minimum is part of an image of closely-spaced lines.

Mask with composite fiber thermal layer

本創作提供一種具有複合纖維保暖層之口罩，其包括一口罩本體和一掛件結構組，該掛件結構組與該口罩本體的側邊相連接；該口罩本體由外而內依序包括一外層、一中間層、以及一內層；該中間層包括一複合纖維保暖層；該複合纖維保暖層包括並列型卷曲纖維、超細纖維及黏結部，該黏結部係位於該並列型卷曲纖維與該超細纖維的交疊處，經該並列型卷曲纖維與該超細纖維熔融而形成；以該並列型卷曲纖維和該超細纖維的總重為基準，該並列型卷曲纖維之含量為10重量%至40重量%，該超細纖維之含量為60重量%至90重量%。藉由具有上述複合纖維保暖層的結構，該口罩的保暖效果良好。

Anti-ST2 antibody and application thereof

Provided are an anti-ST2 antibody or a fragment thereof. The antibody or the fragment thereof can be specifically bound to human ST2, for inhibiting combination of IL-33 and human ST2, blocking an IL-33/ST2 intracellular signaling pathway, and inhibiting the promoting effect of different forms of IL-33 in cell-derived IL-5, IL-6 and Il-8 production. Compared with a known anti-ST2 antibody, this anti-ST2 antibody has higher biological activity, and can be used for preventing, treating, or alleviating diseases related with ST2 expression or IL-33/ST2 pathway disorders.

Document background suppression performed during color space conversion

An electronic image in a first color space, used by image acquisition devices, is obtained and converted into a second color space with a larger gamut, to produce a second color space image. Corrections are made to the second color space image to produce a corrected image, without performing background suppression. The corrected image is converted into a third color space, used by printing devices, to produce a third color space image, and this process of converting the corrected image into the third color space includes performing background suppression. This process of converting the corrected image into the third color space samples nodes of the second color space values, classifies the nodes as background nodes or non-background nodes, multiplies the second color space values of the background nodes by a percentage less than 100%, and after multiplying, interpolates values between the nodes.

Gas turbine engine airfoil

A compressor (130) may include an airfoil (100) configured to rotate about an axis. The airfoil (100) may have a span (S) measured radially from a root (124) of the airfoil to a tip (128) of the airfoil. A compressor case (140) may be radially adjacent to the airfoil (100). The airfoil and the compressor case may define a clearance (144) between the tip (128) of the airfoil and a radially inner surface (142) of the compressor case. A ratio of the clearance to the span may be between 1.5 to 2.5 percent.

Labels and labeling process

This invention relates to labels. In one embodiment the labels comprise a polymer facestock layer (11), a nano-porous layer (12) underlying the facestock, and an adhesive layer (16) underlying the nano-porous layer. In another embodiment, the labels comprise a polymer facestock layer (11), a nano-porous layer (12) underlying the facestock, and a metal layer (13) overlying the facestock (11) or underlying the facestock (11) between the facestock and the nano-porous layer (12). These labels can be bonded to substrates of glass, plastic, or metal using a water based adhesive which is in contact with the nano-porous layer.

Methods for simultaneous determination of serological profile and estimation of duration post hiv infection

The present invention discloses a method and its variations for simultaneous detection of antibodies against two or more antigens of human immunodeficiency virus (HIV) and determination of approximate time (duration) post HIV infection, thereby confirming the infection, and determination of recency of an HIV infection. The number of individuals with recently infected HIV in a given period may be further used to estimate incidence of HIV in a population.

Labels and labeling process

This invention relates to labels. In one embodiment, the labels comprise a polymer facestock layer, a nano-porous layer underlying the facestock, and a metal layer overlying the facestock or underlying the facestock between the facestock and the nano-porous layer. In another embodiment, the labels also comprise a water-based adhesive in contact with the lower surface of the nano-porous layer. These labels can be bonded to substrates of glass, plastic, or metal using a water based adhesive which is in contact with the nano-porous layer.

Determining an orientation direction of a color edge at a pixel location in a color image

What is disclosed is a system and method for determining an orientation direction of a color edge at a given pixel location in a binary color image. The orientation direction of the color edge is determined from eight pixel counts with each pixel count being a total number of pixels in each of eight regions of a window centered about a candidate pixel which resides along the color edge. The eight regions are associated with 8 compass points. The orientation of the edge is determined by a 1 st , 2 nd and 3 rd tier control bits which are based upon the pixel counts of each region. The 1 st , 2 nd and 3 rd tier control bits collectively form a 3-bit word. The 3-bit word defines the orientation direction. The teachings hereof provide an efficient way of performing binary edge orientation detection by making uses of intermediate results to simultaneously encode the edge orientation.

Gas turbine engine airfoil

Submerged structure leakage optical fiber positioning and orienting system and monitoring method without heat source

Charged linkers and their uses for conjugation

Cell binding agent-drug conjugates comprising phosphinate-based charged linkers and methods of using such linkers and conjugates are provided.

Method with credit card discount function and credit card discount platform

本發明關於一種具有刷卡優惠功能之方法：設置刷卡優惠平台；該刷卡優惠平台判斷支付卡交易是否符合優惠活動參數條件；若該支付卡交易符合該優惠活動參數條件，則即時列印優惠券給持卡人；持卡人可利用優惠券條碼或支付卡卡號於指定兌換商店進行核銷。

Pressure sensitive adhesive laminate for high performance noise and vibration damping applications.

Se proporcionan una composición y un laminado adhesivos sensibles a la presión y que tienen propiedades adhesivas y de amortiguación superiores. El laminado adhesivo incluye una composición acrílica de amortiguación que comprende un copolímero de injerto que tiene una cadena principal acrílica y cadenas laterales de macromonómero.

Labels and labeling process

This invention relates to labels. In one embodiment the labels comprise a polymer facestock layer (11), a nano-porous layer (12) underlying the facestock, and an adhesive layer (16) underlying the nano-porous layer. In another embodiment, the labels comprise a polymer facestock layer (11), a nano-porous layer (12) underlying the facestock, and a metal layer (13) overlying the facestock (11) or underlying the facestock (11) between the facestock and the nano-porous layer (12). These labels can be bonded to substrates of glass, plastic, or metal using a water based adhesive which is in contact with the nano-porous layer.

Submerged structure leakage optical fiber positioning and orienting system and monitoring method without heat source

The present invention discloses a heat source-free fiber positioning and orienting system for seepage of submerged or partially submerged structures and monitoring method thereof, which includes a plurality of seepage monitoring devices connected through rotary supports, wherein the seepage monitoring devices include first seepage monitoring units symmetrically distributed on the front and back and second seepage monitoring units symmetrically distributed on left and right, seepage monitoring fibers are distributed in the first seepage monitoring units and the second seepage monitoring units, and the seepage conditions of the submerged or partially submerged structures are monitored through the seepage monitoring fibers. The heat source-free fiber positioning and orienting system for the seepage of submerged or partially submerged structures according to the present invention has the characteristics of no heating, distribution manner, multiple orientations and synchronicity or the like, and has prominent advantages on such aspects like reducing the monitoring cost, improving the monitoring precision and engineering practicability or the like; and through flexibly disposing the seepage monitoring device in the submerged or partially-submerged structures, the seepage position and direction are obtained through comparison of calibrated fibers and the seepage monitoring fibers; therefore, the monitoring method of the present invention is simple to operate and has accurate results.

Drawable and writable photo album

A photo album is provided having an ink-receptive coating on a surface of the photo album. A user may write text or draw pictures on the surface with an ink pen, such as with a gel-based ink pen. The ink-receptive coating protects the ink from smudging or smearing after the ink has dried. Consequently, the text and/or picture is durable. The writable or drawable surface may be the front or back exterior surface, and/or an interior surface.

Autonomous cleaning device

The present disclosure relates to an autonomous cleaning device. The autonomous cleaning device includes: a device body (110), including a chassis (102) and an upper housing (103) fixed to the chassis (102); a drive module (140) connected to the chassis (102) and configured to drive the autonomous cleaning device to advance in a preset path; a cleaning module distributed within the device body (110); and a sensing module (121) assembled to a predetermined position in the upper housing (103) and configured to obtain information of obstacles around the autonomous cleaning device, in which the drive module (140), the cleaning module and the sensing module (121) are separately and detachably assembled to the device body (110).

Novel hydrophilic linkers and ligand-drug conjugates thereof

The present invention provides hydrophilic linkers that are useful for linking drugs to cell-binding ligands in ligand-drug conjugates, such as antibody-drug conjugates. The ligand- drug conjugate comprises a cell -binding ligand capable of binding to a particular cell population, and a drug connected to the ligand by a hydrophilic linker. The hydrophilic linker comprises one or more hydrophilic groups that render the linker hydrophilic. The hydrophilic linker may also comprise functional groups at the two termini for coupling to the drug and the cell-binding ligand respectively.

Motorized covering for a window

A motorized covering for a window, including a selectively positionable plurality of slats; a flexible material layer connected to the plurality of slats, the flexible material layer extending generally parallel to the window when the plurality of slats is in the extended position, a plurality of temporary air cells being formed between the plurality of slats, the flexible material layer, and the window when the slats are in the extended position; and a motor system operatively connected to the plurality of slats and the flexible material layer to selectively lower and raise the slats and the flexible material layer, the motor system being configured to lower and raise the plurality of slats and the flexible material layer in response to at least one control signal, the at least one control signal being based on a determination to change an insulation factor for the window.

Aav triple-plasmid system

Method and apparatus to transmit data through tones

Aspects of the disclosure provide a method for transmitting data. The method includes encoding data, by a first device, symbol-by-symbol into a first electrical signal of frequencies in a specific range, mixing, by the first device, the first electrical signal with a second electrical signal corresponding to captured voices, and transmitting, by the first device, the mixed electrical signal to a second device via a channel being configured for transmitting the captured voices.

Water whitening-resistant pressure-sensitive adhesives

Acrylic emulsion PSA polymers which when cast as a film resist water whitening by hot or ambient temperature water are provided, and are formed by copolymerizing a monomer mixture comprising at least one alkyl acrylate ester of an alcohol containing at least four carbon atoms, at least one polar comonomer and at least one partially water soluble comonomer present in an amount of at least about 7% by weight of the monomers. Polymerization is carried out in the presence of at least one nonionic surfactant containing at least about 8 moles of ethylene oxide per mole nonionic surfactant and at least one anionic surfactant containing up to about 10 moles ethylene oxide per mole anionic surfactant. There is added to the product of polymerization at least one base to produce an emulsion having a pH greater than 7 and containing particles having a mean “volume-average” particle diameter of up to about 210 nm as determined by laser light scattering. An electrolyte is post-polymerization added to stabilize opacity of the adhesive films cast from the emulsion. Applications include autoclavable labels, wet-stick container labels, fleet marking labels and battery labels.

Electric go-kart

Reformatting binary image data to generate smaller compressed image data size

In various exemplary embodiments, systems include a segmentor to segment text binary image data to a first plane. A subtractor subtracts text binary image from binary image data to generate a non-text binary image data in a second plane. A converter converts non-text binary image data in the second plane into non-text gray scale image data in the second plane. A first compressor compresses the text gray scale image data in the first plane. A second compressor compresses the non-text gray scale mage in the second plane.

Rotatable platform

A platform comprising: a base; a first platform unit rotatably mounted to the base and being rotatable about a first axis relative to the base; a second platform unit rotatably mounted to the first platform unit and be rotatable about a second axis relative to the first platform unit; and a flexible transmitting device connected between the base and the first platform unit and/or the first platform unit and the second platform unit for transmitting power and/or data. The flexible transmitting device is arranged to wind about the first axis when the first platform unit is rotated about the first axis and/or wind about the second axis when the second platform unit is rotated about the second axis.

Inspection device for generating height data of a measurement target

An imaging processing part 131 executes first imaging processing of causing a first illuminating part to emit structured light from a first direction to a measurement target, causing an imaging part 120 to generate image data, and causing a buffer memory 133 to store therein the generated image data. A computing processing part 132 executes first computing processing of generating, height data corresponding to the first direction. Concurrently with the first computing processing, the imaging processing part 131 executes second imaging processing of causing the second illuminating part to emit structured light from a second direction to the measurement target, causing the imaging part 120 to generate image data, and causing a buffer memory 134 to store therein the generated image data. The computing processing part 132 executes second computing processing of generating height data corresponding to the second direction.

Automatic cleaning device

An automatic cleaning device includes a mobile platform, a lifting station, a cleaning module, a liquid supplying module, and a collecting module. The mobile platform is configured to automatically move in a target direction on a surface to be cleaned. The lifting station is connected to the mobile platform and configured to move upwards or downwards with respect to the mobile platform. The cleaning module is connected to the lifting station and configured to clean the surface to be cleaned; the liquid supplying module is configured to provide cleaning liquid to the surface to be cleaned; and the collecting module is configured to collect the cleaning liquid. A height of the cleaning module of the automatic cleaning device is adjustable, and the automatic cleaning device has a great cleaning strength and is capable of collecting dirty cleaning liquid, thus, the automatic cleaning device can be applied broadly.

Manual windowing with auto-segmentation assistance in a scanning system

A manual windowing with auto-segmentation assistance method and system are disclosed that include defining manual tags to be assigned to one or more windows via a tag selection module, assigning the defined manual tags to the one or more windows via a manual tag assignment module and auto-segmenting the one or more windows within the display medium by producing auto-segmentation tags via the auto-segmentation module. Furthermore the method and system according to this invention provide for mapping tags to the auto-segmentation tags via a tag mapping module and merging the manual tags and the auto-segmentation tags via a merging module.