12-11-2020 дата публикации
Номер: US20200354359A1
Автор:
Bortolato Andrea,
Bursavich Matthew G.,
Day Tyler,
Dowling James E.,
Gerasyuto Aleksey I.,
Hahn Kristopher N.,
Harrison Bryce A.,
Hickey Eugene,
KIM Byungchan,
Konze Kyle D.,
Lin Fu-Yang,
Lippa Blaise S.,
Qiao Qi,
Rogers Bruce N.,
Sosa Brian,
SVENSSON Mats A.,
Troast Dawn M.,
Zhong Cheng
Принадлежит:
Disclosed are small molecule inhibitors of αvβ6 integrin, and methods of using them to treat a number of diseases and conditions. 130-. (canceled)32. The compound of claim 31 , wherein each Ris independently H claim 31 , alkyl claim 31 , halide claim 31 , alkoxy claim 31 , CF claim 31 , OH claim 31 , alkylene-OH claim 31 , —N(H)R claim 31 , or NH; and Rin C is H claim 31 , (C-C)alkyl claim 31 , or —(C-C)alkylene-O(C-C)alkyl; and Rin A is (C-C)alkyl claim 31 , or —(C-C)alkylene-O—(C-C)alkyl.33. The compound of claim 32 , wherein each Ris independently selected from H claim 32 , halide claim 32 , CF claim 32 , C(H)F claim 32 , C(F)H claim 32 , alkyl claim 32 , cycloalkyl claim 32 , -alkylene-alkoxy claim 32 , hydroxyl claim 32 , and alkoxy; and n with respect to Ris 0 or 1.34. The compound of claim 33 , wherein each Ris independently selected from H claim 33 , halide claim 33 , CF claim 33 , C(H)F claim 33 , C(F)H claim 33 , alkyl claim 33 , cycloalkyl claim 33 , -alkylene-alkoxy claim 33 , hydroxyl claim 33 , and alkoxy.36. The compound of claim 31 , wherein:{'sub': '1', 'a. each Ris independently H, alkyl, halide, or alkoxy;'}{'sub': 3', '3, 'b. each Ris independently selected from the group consisting of: halide, alkyl, and alkoxy; and n with respect to Ris 0 or 1; and'}{'sub': 5', '3', '2', '2, 'c. each Ris independently selected from H, halide, CF, C(H)F, C(F)H, alkyl, cycloalkyl, -alkylene-alkoxy, hydroxyl, and alkoxy.'}37. The compound of claim 36 , wherein Ris independently selected from cycloalkyl claim 36 , and heterocycloalkyl; and Rin C is H.39. The compound of claim 38 , wherein{'sub': '3', 'a. each Ris independently selected from H, and F; and'}{'sub': 'a', 'b. each Ris H.'}41. The compound of claim 31 , wherein:{'sub': '1', 'a. all instances of Rare H;'}b. B is alkylene-O—;{'sub': 3', '3, 'c. each Ris independently selected from H, halide, alkyl and alkoxy; and n with respect to Ris 0 or 1;'}{'sub': '4', 'd. Ris selected from cycloalkyl and ...
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