PIPERIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONIST

The present invention discloses a series of piperidine derivatives as orexin receptor antagonists and compositions thereof, and relates to the application thereof in preparing medications for the treatment of insomnia, chronic obstructive pulmonary disease, obstructive sleep apnea, hypersomnia, anxiety, obsessive-compulsive disorder, panic attack, nicotine addiction, or binge eating disorder.

Chimeric antigen receptor

The present invention provides a chimeric antigen receptor (CAR) which binds a target antigen having a bulky extracellular domain, wherein the CAR comprises a Fab antigen binding domain. The present invention also provides nucleic acid sequences and constructs encoding such a CAR, cells expressing such a CAR and their therapeutic uses.

CHIMERIC ANTIGEN RECEPTOR

The present invention provides a chimeric antigen receptor (CAR) which binds a target antigen having a bulky extracellular domain, wherein the CAR comprises a Fab antigen binding domain. The present invention also provides nucleic acid sequences and constructs encoding such a CAR, cells expressing such a CAR and their therapeutic uses.

Electronic tag for electric power tower

The utility model discloses an electronic tag for an electric power tower. Electronic tag box, a clamping ring is arranged at the lower end of the electronic tag box body; a cover plate is mounted atthe lower end of the clamping ring; an electronic tag module is installed in an inner cavity of the electronic tag box body. An electronic tag chip is installed in the middle of the lower end face ofthe electronic tag module. The right end of the electronic tag chip is connected with an electronic tag antenna; a box body fixing plate is mounted at the upper end of the electronic tag box body; lock catch fixing hoops are connected to the front side and the rear side of the upper end face of the box body fixing plate. According to the electronic tag for the electric power tower provided by theutility model, the electronic tag box body can be fixedly arranged on the electric power tower; and then the lock catch fixing hoop and the lock catch movable hoop are fixed through the lock catch fixing ...

SYSTEMS AND METHODS FOR DETERMINING AN ORDER ACCEPTING MODE FOR A USER

Systems and methods for determining an order accepting mode for a target service provider are provided. A method includes receiving a request for determining an order accepting mode for the target service provider. The method also includes obtaining an order accepting evaluation parameter with respect to the target service provider in response to the request. The method also includes determining an order accepting mode for the target service providers based on the order accepting evaluation parameter. The order accepting mode includes at least one of an order designating mode, an order striving mode, or an order quick-accepting mode. 1. A system configured to operate an online to offline service platform , comprising:at least one storage medium including a first set of instructions for determining an order accepting mode for a service provider terminal associated with the online to offline service platform; andat least one processor in communication with the at least one storage medium, wherein when executing the first set of instructions, the at least one processor is directed to:receive a request for determining an order accepting mode for a target service provider terminal;obtain an order accepting evaluation parameter with respect to a target service provider associated with the target service provider terminal in response to the request; anddetermine an order accepting mode for the target service provider based on the order accepting evaluation parameter,wherein the order accepting mode includes at least one of an order designating mode, an order striving mode, or an order quick-accepting mode.2. The system of claim 1 , wherein the order accepting evaluation parameter includes at least one of a historical driving score associated with the target service provider or a transport capacity of a geographical region in which the service provider terminal associated with the target service provider is located.3. The system of claim 1 , wherein the request for ...

GENES CONFERRING STRESS TOLERANCE IN PLANTS AND USES THEREOF

Compositions and methods for imparting stress tolerance to plants using WRKY nucleic acid and polypeptides.

CHIMERIC ANTIGEN RECEPTOR

The present invention provides a chimeric antigen receptor (CAR) which binds a low density target antigen, which comprises a Fab antigen binding domain. The invention also relates to cells expressing such a CAR and their use in the treatment of disease.

Plant stress tolerance related transcription factor GmNAC20, coding gene and use thereof

The invention discloses the protein related to the stress tolerance of plant, encoding genes and the application thereof, in particular to transcription factors GmNAC20 related to the stress tolerance of plant, the encoding gene and the application thereof. The protein related to the stress tolerance of plant is the following protein in (1) or (2): (1) the protein being composed of amino acid sequences shown in sequence two of a sequence table; (2) the protein comprises the amino acid in the sequence two of the sequence table substituted and/or lacked and/or added and is related to the stresstolerance of plant. The protein related to the stress tolerance and the encoding genes can obviously increase the salt endurance and the low temperature resistance of plants. The protein related to the stress tolerance and the encoding genes are of great significance for breeding stress tolerance plant varieties, in particular to the plant varieties enduring abiotic stresses such as salt endurance and ...

Molecular assessment of TRBC usage

The invention relates to a method of determining the T cell receptor β chain (TRBC) gene type of a cell, the method comprising (a) determining the J gene type expressed in said cell, and (b) inferring from (a) the TRBC gene type expressed in said cell. The invention further relates to use of a CAR T cell targeted to a T cell receptor β chain (TRBC) type 1, or a CAR T cell targeted to a T cell receptor β chain (TRBC) type 2. The invention further relates to a method of medical treatment, and to nucleic acid probes.

POLYNUCLEOTIDES ENCODING RODENT ANTIBODIES WITH HUMAN IDIOTYPES AND ANIMALS COMPRISING SAME

The invention relates to polynucleotides, particularly chimeric polynucleotides useful for optimal production of functional immunoglobulins with human idiotypes in rodents. The invention further relates to rodents comprising such polynucleotides.

Concrete self-heat-preserving brick

The invention discloses a concrete self-heat-preserving brick. The concrete self-heat-preserving brick consists of a rectangular brick body and a plate-like heat-preserving block. The brick body is provided with four rows of elongated grooves in the width direction, the elongated grooves are arranged at equal intervals and penetrate through the upper end surface and the lower end surface, the elongated groove which is located on an odd-number row counted from outside to inside is a one-section groove, and the heat-preserving block is inserted into the elongated groove to form a dual-layer heat-preserving insulation layer. The elongated groove which is located in an even-number row is a two-section groove, and the elongated groove on the position is empty to form a double sound-proof structure. Two end surfaces in the length direction of the brick body are respectively provided with a vertical open slot corresponding to the elongated groove in the odd-number row, and the open slots which ...

Ecological vaccary

The utility model discloses ecological vaccary belongs to the vaccary field, the technical problem that will solve provides ecological vaccary, and the water conservation ceiling of rainwater can be collected in the adoption for the water resource in vaccary obtains saving, and ecological cowshed adopts reasonable distribution, feeds the district and divides with rest area and isolate, makes to feed to eat more conveniently, uses feeding bar to feed the ox simultaneously, and it is more convenient that the messenger raises, the problem of this technique is solved the technical scheme who adopts does: ecological vaccary, including a plurality of ecological cowsheds, ecological cowshed is including water conservation ceiling and receptacle, the water conservation ceiling sets up in the top of receptacle, the receptacle is including the drinking water district, rest area, district and exposure to sunlight district are fed to the fodder, the middle part of position in the receptacle is fed ...

Process for producing reed-shavings board

The technology for making reed board includes making reed into shavings, drying, adding additive to adhesive and mixing, mixing the prepared adhesive with shavings, spreading the mixture, pre-pressing and hot-pressing for shaping. Obtained reed board has plane tensile strength conforming with or near to that of wooden shaving board and its static bending strength and release amount of free formaldehyde are superior to those of wooden shaving board.

Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same

The invention relates to polynucleotides, particularly chimeric polynucleotides useful for optimal production of functional immunoglobulins with human idiotypes in rodents. The invention further relates to rodents comprising such polynucleotides.

Systems and methods for determining an order accepting mode for a user

Chimeric antigen receptor

The present invention provides a chimeric antigen receptor (CAR) which binds a low density target antigen, which comprises a Fab antigen binding domain. The invention also relates to cells expressing such a CAR and their use in the treatment of disease.

MOLECULAR ASSESSMENT OF TRBC USAGE

The invention relates to a method of determining the T cell receptor ß chain (TRBC) gene type of a cell, the method comprising (a) determining the J gene type expressed in said cell, and (b) inferring from (a) the TRBC gene type expressed in said cell. The invention further relates to use of a CAR T cell targeted to a T cell receptor ß chain (TRBC) type 1, or a CAR T cell targeted to a T cell receptor ß chain (TRBC) type 2. The invention further relates to a method of medical treatment, and to nucleic acid probes.

FPGA-based high-speed board card for achieving eight-channel receiving and transmitting serial ports

The invention relates to an FPGA-based high-speed board card for achieving eight-channel receiving and transmitting serial ports. The board card comprises a PCIE connector and an FPGA chip, wherein the FPGA chip comprises a PCIEIP nuclear circuit, a CDMA unit, a transmission control unit and a peripheral interface unit control module, the PCIE connector is in two-way connection with the PCIEIP nuclear circuit through eight pairs of differential serial ports used for receiving signals, eight pairs of differential ports used for transmitting signals, a PCI-E interface used for referring to differential clock signals and a power source, the PCIEIP nuclear circuit is in two-way connection with the CDMA unit, the CDMA unit is in two-way connection with the transmission control unit, and the transmission control unit is in two-way connection with a peripheral interface. An upper computer is connected with the FPGA-based PCI-EX8 high-speed board card, and therefore not only can the upper computer ...

Groove of P type LDMOS device and manufacture method of groove

The invention discloses a groove of a P type LDMOS device. In a P type LDMOS device, a source is required to be electrically connected with a substrate, a polycrystalline silicon deep trench is traditionally adopted, as a result, problems of complex techniques and proneness to formation of electric leakage may be brought about. According to the groove of the P type LDMOS device, a surface channel is formed in a source region so as to connect the source region with the substrate. The invention also discloses a manufacture method of the groove of the P type LDMOS device. According to the manufacture method of the groove of the P type LDMOS device, the source region is opened through wet etching, and the groove is manufactured in the source region, and at the same time, a smooth inner oblique surface of the groove of the source region can be formed through utilizing the isotropy of dry etching, and then, a metal silicide is manufactured subsequently. The groove of the P type LDMOS device and ...

Productive method of medicine for improving growth of liver cell

Preparation method of hollow activated carbon nanofiber aerogel

The invention provides a preparation method of hollow activated carbon nanofiber aerogel, which comprises the following steps: S1, dispersing SiO2 nanofiber in water, adding PAM (Polyacrylamide) under a stirring condition to form uniform colloid, and freeze-drying to obtain physically crosslinked PAM/SiO2 nanofiber aerogel; s2, the PAM/SiO2 nanofiber aerogel is subjected to pre-oxidation and high-temperature carbonization, and carbonized nanofiber aerogel is obtained; and S3, soaking the carbonized nanofiber aerogel in alkali liquor, and then activating at 800-900 DEG C to obtain the nanofiber aerogel. According to the method, SiO2 nanofibers serve as a core layer template, PAM serves as a shell layer activated carbon source, alkali liquor serves as a template removing agent and an activating agent, the activated carbon nanofiber aerogel of a hollow structure is obtained through freeze drying, pre-oxidation, carbonization and activation with a template guiding method, and the activated ...

Piperidine derivatives as orexin receptor antagonist

The present invention discloses a series of piperidine derivatives as orexin receptor antagonists and compositions thereof, and relates to the application thereof in preparing medications for the treatment of insomnia, chronic obstructive pulmonary disease, obstructive sleep apnea, hypersomnia, anxiety, obsessive-compulsive disorder, panic attack, nicotine addiction, or binge eating disorder.

HUMAN ANTIBODIES FROM TRANSGENIC RODENTS WITH MULTIPLE HEAVY CHAIN IMMUNOGLOBULIN LOCI

The invention relates to transgenic animals useful for optimal production of functional immunoglobulins with human idiotypes.

Digital TV program menu association system and method

The association system for digital TV program menu includes digital TV signal source, and digital TV set connected to each other through transmission network. The digital TV set includes main controller, memory connected to the said main controller, signal process module, audio and video play back module. The said digital TV set also includes program association module in use for analyzing information of program in digital TV signal based on program association instruction of the said main controller so as to obtain program information associated to the corresponding TV program, and store the association to the said memory. The invention can collect related programs user wishes to watch so as to make user possible to layout list of program to be watched by self. Thus, the programs to be watched will not be missed out. Moreover, user will not waste time to look up TV program one station by one station.

CHIMERIC ANTIGEN RECEPTOR

The present invention provides a cell comprising first and second chimeric antigen receptors (CARs), which bind to different antigens, wherein the first CAR binds to Transmembrane activator and calcium modulator and cyclophilin ligand (CAML) interactor (TACI). The present invention also provides a cell comprising a tanCAR comprising first and second antigen-binding domains which bind to different antigens, wherein the first antigen binding domain binds the antigen Transmembrane activator and calcium modulator and cyclophilin ligand (CAML) interactor (TACI). The present invention further provides corresponding nucleic acid sequences and /or constructs, kits and vectors comprising said nucleic acid sequences and/ or constructs, molecules and methods for making such cells. The cells may be used in cellular immunotherapy approaches for treating diseases such as multiple myeloma.

PIPERIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONIST

The present invention discloses a series of piperidine derivatives as orexin receptor antagonists and compositions thereof, and relates to the application thereof in preparing medications for the treatment of insomnia, chronic obstructive pulmonary disease, obstructive sleep apnea, hypersomnia, anxiety, obsessive-compulsive disorder, panic attack, nicotine addiction, or binge eating disorder.

Array substrate of liquid crystal display device

The invention relates to an array substrate of a liquid crystal display device, comprising grid lines, data wires and pixel electrodes which are formed on the substrate, wherein the pixel electrodes are arranged in a pixel area limited by the grid lines and the data wires, and concave and convex shapes capable of generating liquid crystal disclinations are arranged on the edges of the pixel electrodes near to the data wires, i.e. concave and convex shapes such as rectangular gaps, triangular gaps, trapezoidal gaps or arch-shaped gaps are arranged on one side of the pixel electrodes near the data wires at interval. As for the array substrate of the liquid crystal display device, the liquid crystal disclinations are formed on the edge regions of the pixel electrodes near to the data wires, thus the edge regions between the pixel electrodes and the data wires become light proof areas by the light proof property of the liquid crystal disclinations, and the problem of light leakage existing ...

Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same

The invention relates to polynucleotides, particularly chimeric polynucleotides useful for optimal production of functional immunoglobulins with human idiotypes in rodents. The invention further relates to rodents comprising such polynucleotides.

Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same

C:\Interoven\NRPortbl\DCC\FMT629114_l.doex-30/08/2018 The invention relates to polynucleotides, particularly chimeric polynucleotides useful for optimal production of functional immunoglobulins with human idiotypes in rodents. The invention further relates to rodents comprising such polynucleotides. WO 2014/093908 PCT/US2013/075157 Fig.1I 8 IgH BACs (550 kb) AV0& (\-\{) N'' Xv1,\t' ,K Al'<) xW A 4, 4 " 4"F4 \ 4 bg&BACs(v300 kb) N! N"N N' k "IN " j4<i 0' K 0Q4N K 4o CigYAC(1300 kb) 1\/IV' v ~ \~l<~ \V\~v''K2< No< \& K~c\ %\%s~\i0

Concrete self-heat-preserving angle brick

The invention discloses a concrete self-heat-preserving angle brick. The concrete self-heat-preserving angle brick consists of a rectangular brick body and a plate-like heat-preserving block. The center of the brick body in the length direction is provided with a transverse rectangular groove penetrating through the upper end surface and the lower end surface, the heat-preserving block is inserted into the rectangular groove to form an insulation structure in the length direction, two sides of the rectangular groove on the lower end surface of the brick body are respectively provided with vacant blind holes, and the vacant blind holes form a sound-proof structure of the brick body. By adopting the structure that the heat-preserving block and the vacant blind holes are inserted into the rectangular groove, the good heat preserving and sound-proof effects are achieved, the weight is also greatly reduced, and the concrete self-heat-preserving angle brick is a novel wall material for substituting ...

Low pressure hybrid vehicle battery system

The utility model belongs to the technical field of car electrical control, a low pressure hybrid vehicle battery system is provided, including boost module for stepping up of hybrid vehicle's load end voltage, collection module is used for gathering the battery package terminal voltage of battery package with load end voltage, control module for control boost module opening or closing, the major loop is used for the circuit of load power supply, state boost module collection module with the major loop respectively with control module signal connection, the control module basis collection module's information control boost module opening or closing, and control major loop switch-on or disconnection. The utility model discloses increase boost module, direct control boost module promotes load end voltage, reduces hardware and connects and the hardware cost, and easy operation simplifies procedures, and the control of being convenient for can improve whole car production efficiency.

Testing method and testing device for low-temperature cracking resistance performance of asphalt beam

The invention discloses a testing method for the low-temperature cracking resistance performance of an asphalt beam. The testing method comprises the following steps: cooling an asphalt beam test piece to a test temperature; putting the asphalt beam test piece onto a bracket which can provide two-point supporting for the asphalt beam test piece; continuously applying a constant vertical load P to the middle crossing-over part of the middle asphalt beam test piece; recording deflection delta of the middle crossing-over part when the asphalt beam test piece is yielded; calculating the stiffness modulus S of asphalt; calculating the strain rate m of the asphalt; and comprehensively evaluating the low-temperature cracking resistance performance of the asphalt through the stiffness modulus S and strain rate m of the asphalt. The testing method can make up for the defect that the low-temperature cracking resistance performance of the asphalt cannot be sufficiently evaluated according to existing ...

QtDBus-based software watchdog implementation method

The invention provides a QtDBus-based software watchdog implementation method, which comprises the following steps that: during power-on, an application program communicates with a software watchdog in real time based on a daemon process QtDBus; the application program outputs a log file to the software watchdog; the software watchdog monitors the application program and judges whether the application program is normal or not according to a monitoring result, and if the application program is normal, the monitoring process continues to be executed; and if the application program is abnormal, storing the log file to a fault directory, and restarting the application program. According to the method, the watchdog program can ensure that the running log is stored when the application program is abnormal, and only the effective fault log is stored, so that the space of a hard disk can be effectively reduced. In the later troubleshooting process, the problem troubleshooting can be carried out ...

POLYNUCLEOTIDES ENCODING RODENT ANTIBODIES WITH HUMAN IDIOTYPES AND ANIMALS COMPRISING SAME

Chimeric antigen receptor

The present invention provides a chimeric antigen receptor (CAR) which binds a target antigen having a bulky extracellular domain, wherein the CAR comprises a Fab antigen binding domain. The present invention also provides nucleic acid sequences and constructs encoding such a CAR, cells expressing such a CAR and their therapeutic uses.

Array substrate of liquid crystal display device

The invention relates to an array substrate of a liquid crystal display device, comprising grid lines, data wires and pixel electrodes which are formed on the substrate, wherein the pixel electrodes are arranged in a pixel area limited by the grid lines and the data wires, and concave and convex shapes capable of generating liquid crystal disclinations are arranged on the edges of the pixel electrodes near to the data wires, i.e. concave and convex shapes such as rectangular gaps, triangular gaps, trapezoidal gaps or arch-shaped gaps are arranged on one side of the pixel electrodes near the data wires at interval. As for the array substrate of the liquid crystal display device, the liquid crystal disclinations are formed on the edge regions of the pixel electrodes near to the data wires, thus the edge regions between the pixel electrodes and the data wires become light proof areas by the light proof property of the liquid crystal disclinations, and the problem of light leakage existing ...

Starting lifting platform for packaging

The invention discloses a starting lifting platform for packaging, and belongs to the technical field of lifting platforms, height sensing pieces are mounted on the inner wall of a sliding groove, height display sensing pieces are mounted on the two sides of the outer wall of a limiting rod, piston rods are mounted at the output ends of pulling telescopic rods, and the piston rods are in lifting connection with connecting rods on a first folding rod and a second folding rod; a pulling telescopic rod is started to push a piston rod, a first folding rod, a second folding rod and a connecting rod to ascend and descend, in the ascending and descending process, a height sensing piece and a height display sensing piece make contact with each other to detect the height and transmit the height to equipment, and after the equipment ascends to a certain height, a positioning telescopic rod can be started to push a positioning piston rod to stretch out and draw back; the positioning piston rod stretches ...

Chimeric antigen receptor

The present invention provides a cell comprising first and second chimeric antigen receptors (CARs), which bind to different antigens, wherein the first CAR binds to Transmembrane activator and calcium modulator and cyclophilin ligand (CAML) interactor (TACI). The present invention also provides a cell comprising a tanCAR comprising first and second antigen-binding domains which bind to different antigens, wherein the first antigen binding domain binds the antigen Transmembrane activator and calcium modulator and cyclophilin ligand (CAML) interactor (TACI). The present invention further provides corresponding nucleic acid sequences and /or constructs, kits and vectors comprising said nucleic acid sequences and/ or constructs, molecules and methods for making such cells. The cells may be used in cellular immunotherapy approaches for treating diseases such as multiple myeloma.

Systems and methods for determining an order accepting mode for a user

Systems and methods for determining an order accepting mode for a target service provider are provided. A method includes receiving a request for determining an order accepting mode for the target service provider. The method also includes obtaining an order accepting evaluation parameter with respect to the target service provider in response to the request. The method also includes determining an order accepting mode for the target service providers based on the order accepting evaluation parameter. The order accepting mode includes at least one of an order designating mode, an order striving mode, or an order quick-accepting mode.

Main girder structure system of double-layer bridge deck cable-stayed bridge

The invention discloses a main girder structure system of a double-layer bridge deck cable-stayed bridge. The structure system comprises a mid-span main girder and a side-span main girder, and is characterized in that the mid-span main girder adopts the combination of a plate truss and a steel truss girder, and the side-span main girder adopts a structure system of a composite truss girder. The structure system can effectively shorten the side-span span to prevent the side-span weight, keeps the appearance consistency of the whole bridge main girder, and has higher promotion values on such aspects as economy, bridge landscape and driving comfort.

System and method for providing inter-vehicle communications amongst autonomous vehicles

A cloud server maintains a neighboring vehicle data structure storing vehicle information of vehicles coupled to the cloud server over a network. The server receives a first request from a first of the vehicles, including a first vehicle identifier (ID) and current vehicle metadata of the first vehicle. In response to the first request, the server traverses the neighboring vehicle data structure to update a first node corresponding to the first vehicle based on the first vehicle ID and the current vehicle information of the first vehicle. The server transmits to the first vehicle over the network a list of one or more vehicle IDs identifying one or more vehicles that are within a predetermined geographic proximity of the first autonomous vehicles to allow the first vehicle to directly communicate with any vehicle in the list via a wireless local area network.

Transcription factor AtGT4, coding gene thereof and applications

The invention discloses a transcription factor AtGT4, a coding gene thereof and applications. A protein provided by the invention is one of the following proteins having an amino acid residue sequence: (a) a protein having the amino acid sequence shown in a sequence 2 in a sequence table; and (b) a protein which is obtained by carrying out substitution and/or deletion and/or addition of one or more amino acid residues on the amino acid sequence shown in the sequence 2 in the sequence table. Tests prove that a gene with salt tolerance is found. The gene has important value in the aspects of culturing adverse-resistant plant varieties, particularly new varieties such as abiotic stress resistant (salt resistant) crops, forests and grass, and the like. The gene can be used for culturing and identifying adverse-resistance plant varieties which are required by the agriculture and animal husbandry and by ecological environment management, and has important meaning to improvement of the crop yield ...

SYSTEM AND METHOD FOR PROVIDING INTER-VEHICLE COMMUNICATIONS AMONG AUTONOMOUS VEHICLES

According to an embodiment of the present invention, a vehicle identifier (ID) and vehicle information of a first autonomous vehicle are transmitted to a cloud server communicatively coupled to a plurality of autonomous vehicles via a network. A list of one or more vehicle identifiers (IDs) is received from the cloud server. The vehicle IDs identify one or more autonomous vehicles within predetermined geographic proximity of the first autonomous vehicle. The first autonomous vehicle communicates with a second autonomous vehicle selected from the list of one or more autonomous vehicles via a wireless local area network to exchange an operational status between the first autonomous vehicle and the second autonomous vehicle. COPYRIGHT KIPO 2018 (601) Acquire vehicle information (e.g., latitude, longitude, and altitude) of a first autonomous vehicle (602) Transmit the vehicle information to a cloud server from the first autonomous vehicle via a cloud network (603) Receive one or more vehicle ...

Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same

C: \Interwoen\NRPortbl\DCC\FMT629114_i.doex-30/08/2018 The invention relates to polynucleotides, particularly chimeric polynucleotides useful for optimal production of functional immunoglobulins with human idiotypes in rodents. The invention further relates to rodents comprising such polynucleotides. WO 2014/093908 PCT/US2013/075157 Fig.1I 8 IgH BACs (-550 kb) N '0 1511 tg' "I, A~~& N-\N' 1 b g& BACs (v300 kb) N! N"N N'k "IN " j 4< 0' K 0Q4N K 4o C igk, YAC (1300 kb) )'\l R {($N &$x K>K"41c> A 1\/IV I ~ I~ VN ...

Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same

The invention relates to polynucleotides, particularly chimeric polynucleotides useful for optimal production of functional immunoglobulins with human idiotypes in rodents. The invention further relates to rodents comprising such polynucleotides.

Bridge deck pavement method for orthotropic steel bridge

The invention discloses a bridge deck pavement method for an orthotropic steel bridge. The pavement method comprises the following steps: (1) performing sand-blasting and de-rusting treatment on a steel bridge panel, and coating a mica-containing epoxy anti-corrosion layer; (2) coating a solvent-free epoxy resin water-proof layer; (3) spreading a hot melt particle bonding layer which is partially sunken into the solvent-free epoxy resin water-proof layer, wherein the hot melt particles are high-polymer particles of which the softening point is greater than 150 DEG C; (4) paving a fine-particle asphalt mixture to form a high-elasticity modified asphalt pavement lower layer; (5) spreading a modified emulsified asphalt bonding layer; (6) paving a fine-particle or medium-particle asphalt mixture to form a high-elasticity modified asphalt pavement upper layer. By adopting the pavement method, the construction difficulty is lowered greatly, later maintenance is easy, the universality is high, ...

Pretreatment method for mercury-free determination of chemical oxygen demand of high-chlorine surface water and preparation of digestion solution

The invention discloses a pretreatment method for monitoring mercury-free determination of chemical oxygen demand in high-chlorine surface water and a preparation method of a digestion solution. The method comprises the following steps: adding concentrated sulfuric acid into a high-chlorine water sample, releasing interferent chloride ions in the form of hydrogen chloride under heating and blowing conditions, removing interference of a small amount of residual chloride ions by adopting a self-made digestion solution, and directly measuring the chemical oxygen demand of the sample. Wherein the digestion solution comprises the following effective components: 0.025 mol/L potassium dichromate solution, 98% concentrated sulfuric acid and silver sulfate. By adopting the method, the chemical oxygen demand of a water sample with the chloride ion concentration of below 50000 mg/L and the CODCr value of less than or equal to 50 mg/L can be directly measured, and when the chloride ion concentration ...

Crop non-damage seedling transplanting device and seedling transplanting method

The crop damage-free seedling transplanting device comprises a top plate, a seedling transplanting mechanism is arranged on the top plate, the seedling transplanting mechanism comprises two sleeves which are fixedly installed on the lower surface of the top plate, motors are fixedly installed on the upper surfaces of inner cavities of the sleeves, threaded rods are fixedly installed at the output ends of the motors, and the threaded rods are fixedly installed on the lower surfaces of the sleeves. The outer surface of the threaded rod is in threaded connection with a threaded sleeve, a connecting block penetrating to the outer surface of the sleeve is fixedly installed on the outer surface of the threaded sleeve, and a fixing block is fixedly installed on the surface of the side, away from the threaded sleeve, of the connecting block. According to the crop damage-free seedling transplanting device and the seedling transplanting method, the sleeve is arranged on the lower surface of the top ...

Piperidine derivatives as orexin receptor antagonist

The present invention discloses a series of piperidine derivatives as orexin receptor antagonists and compositions thereof, and relates to the application thereof in preparing medications for the treatment of insomnia, chronic obstructive pulmonary disease, obstructive sleep apnea, hypersomnia, anxiety, obsessive-compulsive disorder, panic attack, nicotine addiction, or binge eating disorder.

Human antibodies from transgenic rodents with multiple heavy chain immunoglobulin loci

The invention relates to transgenic animals useful for optimal production of functional immunoglobulins with human idiotypes.

Alprostadil preparation and its making method

Master-slave type whole vehicle electric energy management system and method and electric vehicle

The invention provides a master-slave type whole vehicle electric energy management system and method and an electric vehicle. The master-slave type whole vehicle electric energy management system comprises a master control module, a slave control module, a power battery, a low-voltage storage battery, a high-voltage load, a low-voltage load, a direct-current converter and a low-voltage load controller. The main control module obtains high-voltage use load power and a motion driving power request of the vehicle; the slave control module estimates the electric power of the low-voltage load and feeds back the estimation result and the state information of the low-voltage storage battery to the master control module; the main control module estimates the electric energy demand of the whole vehicle according to the electric power of the low-voltage load, the use power of the high-voltage load and the motion driving power request of the vehicle, and selects to carry out power limitation or closing ...

Equipment of measuring ring oxygen tree fat trabecula tensile deformation restorability

The utility model provides an equipment of measuring ring oxygen tree fat trabecula tensile deformation restorability, includes step motor loading device, water bath circulation temperature control system and camera device, wherein, water bath circulation temperature control system opening orientation water bath circulation box up, the middle part of water bath circulation box is provided with the baffle, has offered a plurality of mounting holes on this baffle, still is provided with the temperature controller who is used for adjusting the interior temperature of water bath circulation box in the water bath circulation box, step motor loading device includes E type installing support, smooth thick stick, stiff end anchor clamps, expansion end anchor clamps, lead screw and motor etc, camera device is used for observing the trabecular camera of epoxy including fixing at water bath circulation box top to and be used for collecting the video capture card of camera data. The utility model discloses ...

Sweet potato rotary tillage ridging transplanting combined operation machine

The invention relates to a sweet potato rotary tillage ridging transplanting combined operation machine suitable for transplanting an exposed sweet potato seedling, and belongs to the technical field of agricultural planting machinery. The combined operation machine comprises a transplanting unit and a rotary tillage ridging unit which are connected by a connection frame; the outside of traction plates, forwards extending, at two sides of the middle of a horizontal main rod of the connection frame is fixedly connected with a rotary tillage unit; a pair of traction plates downwards extend to a stubble pressing disc; a ground wheel assembly at the front side of the transplanting unit is provided with a transmission shaft in transmission connection with a power input end of the transplanting unit; a working chain wheel is arranged at one side of the ground wheel; the working chain wheel is in transmission connection with a driven chain wheel on the transmission shaft by a chain; a ridge repairing ...

Manufacturing method for improving in-plane uniformity of P type LDMOS surface channel device

The invention discloses a manufacturing method for improving the in-plane uniformity of a P type LDMOS surface channel device. Polysilicon and metal silicide are used as a grid. Channel injection, long-time high-temperature propulsion, an N type heavily doped polysilicon electrical connecting sinking process and a polysilicon grid boron ion doping process are orderly used. Boron doping is not carried out when the grid is formed, so that long-time high-temperature propulsion can be carried out to form a sufficiently wide channel, and device penetration or electrical leakage, which is caused by a short channel effect, can be avoided. After a lightly doped drain drift region is formed, silicon oxide depositing is carried out and the N type heavily doped polysilicon electrical connecting sinking process is carried out, so as to form a grid polysilicon side wall. Boron injection is carried out on the polysilicon grid. The long-time high-temperature propulsion process is avoided after boron injection ...

Horizontal displacement release

The utility model discloses a horizontal displacement release sets up between jacking support and jack, the jacking support sets up under the jack, this horizontal displacement release contains: the steel sheet sets up between jacking support and the jack, board -like rubber support sets up between jacking support and the steel sheet, wherein the last reason of steel sheet with the hood of jack is inconsistent, board -like rubber support's lower edge with the top of jacking support is inconsistent. The utility model discloses can reduce or control because the supertronic rotates the jacking level of support displacement that jacking, temperature effect etc. Produced during the bridge jacking, guarantee the safety of jacking support. The utility model discloses in the aspect of the security of effective lift bridge back shengji art, suitability, played the important function, be worth promoting and using.

Outer clean system of diesel engine machine and fixed subassembly thereof

The utility model discloses an outer clean system of diesel engine machine and fixed subassembly thereof, should fixed subassembly include the staple bolt with weld in the support of staple bolt upper surface, the vertical section of this support is trapezoidal, just trapezoidal keeping away from the top surface width of staple bolt is less than this trapezoidal orientation the bottom openings width of staple bolt, the bottom openings department of support is provided with the turn -ups, and passes through the turn -ups weld in the staple bolt, the turn -ups with the welding seam of staple bolt the setting is interrupted to the thickness direction of staple bolt, like this, the support that should fix the subassembly is the trapezium structure, and the angle of buckling of its department of buckling is the obtuse angle, and owing to the angle of the department of buckling is more little, its stress concentration is obvious more, so compares with prior art's right angle form, and the support ...

Electrical assembly box of new energy automobile

The utility model provides an electrical assembly box of a new energy automobile, and relates to the technical field of new energy automobile accessories, in particular to the electrical assembly box of the new energy automobile, which comprises a box body and a box sleeve, stand columns are arranged at two ends of the box body, a placing groove is arranged between the stand columns, the box body is placed in the placing groove, and lining plates are arranged at two ends of the box sleeve. A round hole is formed in the lining plate, and the box sleeve penetrates through the round hole through a bolt to be fastened to an automobile body; a heat dissipation device is arranged in the containing groove and comprises an annular heat dissipation pipe, and the annular heat dissipation pipe is placed on the box sleeve through a fixing column. The annular heat dissipation pipes are communicated with external circulating cooling liquid; the vertical plate is placed on the annular heat dissipation ...

Water soluble waterproof silicon acrylate paint

A water-soluble silicone acrylate water-proof paint is a macromolecular synthetic green water-proof paint. It is made up by using (wt%) 4%-9% of mica powder, 54%-75% of acrylic acid. 5%-25% of potassium base sodium silicate and 5%-12% of alcohol ester. Said invented water-proof paint is applicable to waterproofing and leak preventing of roof constructino, underground structure, external wall and internal wall of large building, and can be applied to the base surface of cement, metal, wood and paper, and can be formed into various macromolecular colloidal film layer, so that it possesses strong water-proofing function, and its adhesive force in strong and performance is stable.

Application of protein GmDREB2AL and correlated biological material to regulate and control seed plant grease and thousand grain weight

The invention discloses application of protein GmDREB2AL and a correlated biological material to regulate and control seed plant grease and thousand grain weight. One kind of application is a method for culturing transgenic seed plants with high total grease content, aliphatic acid content and thousand grain weight. The method comprises: introducing coding gene of GmDREB2AL into an acceptor seed plant, so as to obtain the transgenic seed plant. The GmDREB2AL is a) protein with the amino acid sequence shown as SEQ ID No. 2, or b) protein which is derived from a) by substituting and/or deleting and/or adding one or more amino acid residues on the basis of the protein shown as SEQ ID No. 2, and is correlated with the seed total grease content and/or aliphatic acid content and/or seed thousand grain weight. GmDREB2AL gene is applicable to increase and improve grease compositions, increase output and culture high-grease high-output species.

Continuous-phase frequency-shift keying digital demodulation device and demodulation method implemented by same

The invention relates to a digital demodulation device, in particular to a continuous-phase frequency-shift keying digital demodulation device and a demodulation method implemented by the same. The continuous-phase frequency-shift keying digital demodulation device comprises a comparator device and a field-programmable gate array device. An internal circuit of the field-programmable gate array device comprises a clock unit, a sampling unit, a counting unit, a buffer unit and a reconstruction unit, and the clock unit is connected with the sampling unit, the counting unit, the buffer unit and the reconstruction unit; the comparator device is connected with the sampling unit; the sampling unit is connected with the counting unit; the counting unit is connected with the buffer unit; the buffer unit is connected with the reconstruction unit. The continuous-phase frequency-shift keying digital demodulation device and the demodulation method have the advantages that the demodulation device has ...

Water soluble waterproof silicon acrylate paint

Automatic text scanning machine

The invention relates to an automatic text scanning machine, belonging to the technical field of instruments. The automatic text scanning machine comprises a vacuum compressing pump, an automatic page-turning mechanism, a camera shooting module, a PLC (programmable logic controller), compressing mechanisms, a V-shaped supporter, an illuminating light source, an operation end prompt module, an operation panel and a machine body, wherein the vacuum compressing pump supplies power to a sucker and a cylinder in the automatic page-turning mechanism and cylinders in the compressing mechanisms; the automatic page-turning mechanism comprises a servo motor (or stepping motor), a driver, a gear set, a connection rod, the cylinder and the sucker; the PCL is used for controlling operation; the camera shooting module is arranged above the V-shaped supporter and shoots books by using a self-focusing digital camera; the books are placed on the V-shaped supporter; and the compressing mechanisms are arranged ...

Bufalin derivative as well as preparation method, pharmaceutical composition and application thereof

The invention relates to a bufalin derivative having a structure represented as a general formula I, wherein R is selected from one of the following structure groups as shown in the specification, or pharmaceutically acceptable salt, as well as a preparation method, a pharmaceutical composition and application of the derivative. The bufalin derivative has an activity on inhibiting tumor cell lines, and can be used as a medicine for treating malignant tumors.

Non-volatile memory with assembly structure and manufacturing method thereof

The invention provides a manufacturing method of a nonvolatile memory with a pairing structure. The manufacturing method comprises the steps that a first bit line is formed in a second dielectric layer on a substrate, the first bit line is electrically connected with a second source-drain region of a first storage tube, and a first barrier layer in the second dielectric layer at least wraps the side wall of the first bit line; forming a second groove in the fourth dielectric layer on the second dielectric layer, wherein the second groove is internally covered with a second barrier layer; forming an opening in the second barrier layer on the bottom surface of the second groove; the second dielectric layer is etched downwards in a self-alignment mode from the opening to form a second through hole, in the process of etching to form the second through hole, the first barrier layer limits the side wall forming position of the second through hole, and part of the side wall of the first barrier ...

Channel-type power MOSFET (metal-oxide-semiconductor field effect transistor) device

The invention discloses a channel-type power MOSFET (metal-oxide-semiconductor field effect transistor) device. The channel-type power MOSFET device comprises a first array structure which is used for forming a grid and consists of first deep channels, wherein the first array structure comprises a plurality of rows and a plurality of lines; the length direction of the first deep channels is the same as the row direction; each row of the first deep channels are arranged at equal intervals; in the line direction, each line of the first deep channels are arranged at equal intervals; the first deep channels of adjacent rows are crossed; two alternated rows of the first deep channels are aligned. By the channel-type power MOSFET device, stress generated by the deep channels can be released effectively, and the dislocation can be reduced.

Image acquisition device of high-flux portable colloidal gold CCD (Charge Coupled Device) reader

The utility model discloses an image acquisition device of a high-flux portable colloidal gold CCD reading instrument. The device comprises a base, a CCD camera and a CCD camera support, an open slotis formed in the base; a T-shaped guide rail is arranged on the base; a movable sample chamber matched with the T-shaped guide rail is arranged on the T-shaped guide rail; the sample chamber is provided with a plurality of sample grooves; a threaded through hole is formed in the bottom of the sample chamber; the image acquisition device further comprises a motor used for controlling the sample chamber to move back and forth and a motor control device used for accurately positioning the position of the sample chamber, the motor is arranged on a motor base, a lead screw is arranged on the motor,and the lead screw penetrates through the threaded through hole and is installed in cooperation with the threaded through hole. The image acquisition device can automatically detect a plurality of samples ...

Circuit for realizing high and low level identification by adopting optocoupler

The invention discloses a circuit for realizing high and low level identification by adopting an optocoupler, which is suitable for three state changes. The circuit comprises a resistor R1, a resistor R2, a resistor R4 and an optocoupler OPT1, the resistor R1 is connected with the power supply end VDD1, the other end of the resistor R1 is connected with the anode of a body diode of the optical coupler OPT1, the connection point of the cathode of the body diode of the optical coupler OPT1 and one end of the resistor R4 is a signal input pin, the power supply end VCC1 is connected with one end of the resistor R2, the other end of the resistor R2 is connected with the collector electrode of a body triode of the optical coupler OPT1, and the other end of the resistor R4 is connected with the power supply end VCC1. Meanwhile, an emitting electrode of a body triode of the optocoupler OPT1 is connected with a grounding end GND; the electrical isolation of the input end and the output end is realized ...

Method, apparatus and equipment for screen to display variable

The invention is applicable to the television field of and provides a method, a device and equipment which are used for adjusting the screen displaying variable; the method includes the steps that: the command for adjusting the screen displaying variable is received, the command contains adjusting type information of the screen displaying variable; whether accurate adjusting is carried out on the screen displaying variable is judged according to the adjusting type information of the screen displaying variable, if yes, the adjusting step value of the screen displaying variable is decreased and the screen displaying variable is adjusted according to the decreased adjusting step value of the screen displaying variable, if not, the screen displaying variable is adjusted according to the original adjusting step value of the screen displaying variable. In the invention, by dividing the controlling and adjusting variable of a multimedia device into two types and setting the magnifying and the ...

Automatic cell processing equipment

The invention provides automatic battery cell processing equipment which comprises a circulating conveying line, a feeding mechanism, a cleaning mechanism, a first turnover mechanism, an insulating cover mounting mechanism, a second turnover mechanism and a buffer pad mounting mechanism, a feeding station, a cleaning station, a first overturning station, an insulating cover mounting station, a second overturning station and a cushion mounting station are arranged on a conveying path of the circulating conveying line; the feeding mechanism is arranged on the side of the feeding station and used for feeding the battery cells to the circulating conveying line. The cleaning mechanism is used for cleaning the battery cell; the first turnover mechanism is used for turning over the battery cell to enable the mounting surface of an insulating cover of the battery cell to face upwards; the insulating cover mounting mechanism is used for mounting an insulating cover on the battery cell; the second ...

High ridge excavation potato class of cutting edge in a narrow margin harvesting apparatus

The utility model discloses a high ridge excavation potato class of cutting edge in a narrow margin harvesting apparatus, which comprises a frame. Be equipped with the traction frame that is used for connecting draw gear in the frame, the below of frame is equipped with the supporting wheel, the front end of frame is equipped with brokenly the ridge sword, still be equipped with gear box casing, driving pulley and from the driven pulleys in the frame, gear box casing passes through driving belt and links to each other with driving pulley, driving pulley passes through the bar strip elevating chain and links to each other with from the driven pulleys, be equipped with a plurality of bar strips on the bar strip elevating chain. The utility model relates to a have that narrow, the high ridge of operation width side surely breaks ground, put together together in the rear end, antiwind potato class harvesting apparatus, can once accomplish the excavation, play the potato, transport, the miscellaneous ...

Anticoagulant compound, preparation method and application of anticoagulant compound and drug composition containing anticoagulant compound

The invention relates to a compound shown in a general formula (I) or a general formula (II) in the specification and a stereoisomer or physiologically acceptable salts thereof and also relates to a preparation method and application of the compound. Besides, the invention also relates to a drug composition containing the compound and an application of the drug composition. The compound which is provided by the invention and can serve as a thrombin and/or blood platelet GPIIb/IIIa receptor inhibitor has good in-vitro human thrombin inhibiting activity, in-vitro blood platelet GPIIb/IIIa receptor inhibiting effects and in-vitro/in-vivo anti-platelet aggregation effects, and does not have obvious toxicity. The compound provided by the invention has a novel structure and good biological activity, is simple and convenient to synthesize and is a drug with good application prospects and anticoagulation effects.

Roller for mung bean huller capable of evenly stirring, shovelling and screening materials in real time

Provided is a roller for a mung bean huller capable of evenly stirring, shovelling and screening materials in real time. The roller comprises a roller body, one end of the roller body is arranged on a rack bearing pedestal, the other end of the roller body is arranged on a rack mounting seat, the roller body can rotate around the axial center of the roller body, a mesh screen is arranged on the surface of the roller body, the inner wall of the roller body stretches out of a shovelling plate, and a hulling grinding wheel is arranged in the axial center of the roller body. The roller is characterized in that round holes or long round holes are formed in the mesh screen of the surface of the roller body, the shovelling plate on the inner wall of the roller body is divided into a plurality of sets in the circumferential direction at intervals, and three pieces form one set and are evenly distributed on the inner wall of the circumferential roller body at intervals. The round holes or the long ...

SYSTEM AND METHOD FOR PROVIDING AUGMENTED VIRTUAL REALITY CONTENT IN AUTONOMOUS VEHICLE

In one embodiment, a server receives a request for content transfer from a first autonomous vehicle. In response to the request, visual analysis is performed on an image acquired from the request to determine the 3D positioning information of the image. A content item list is identified based on the current vehicle information of a first autonomous vehicle and the user profile of a user in the first autonomous vehicle. Based on the 3D positioning information of the image, a first content item selected from the content item list is added to the image to generate an augmented image. The augmented image to be displayed in a virtual reality manner to the display device in the autonomous vehicle is transmitted to the first autonomous vehicle. COPYRIGHT KIPO 2017 (601) Receiving an image selectively including one or a plurality of user IDs of users boarding in an autonomous vehicle from the autonomous vehicle through a network (602) Perform visual analysis for an image to determine 3D positioning ...

Composition for preventing or treating bone and joint disease and preparation method and application

The invention provides a composition for preventing or treating bone and joint diseases. The composition comprises D-glucosamine or salt of D-glucosamine, a calcium compound and soy isoflavone, wherein the weight ratio of the D-glucosamine or salt of the D-glucosamine to the calcium compound to the soy isoflavone is (2.5-5.0):(1.6-4):(0.2-1.0). The invention further provides a preparation method of the composition. Pharmacological study results show that the composition has a remarkable calcium supplement effect and an estrogen-like effect, and can effectively suppress osteoclast function so as to treat osteoporosis, and meanwhile the composition provided by the invention further has the capability to stimulate chondrocyte to generate and prompt repairing capability of chondrocyte, and bone and joint diseases can be effectively prevented and treated.

Multistage combined grinding machine for straws

The invention relates to a multistage combined grinding machine for straws and belongs to the technical field of agricultural and forestry machinery. The grinding machine comprises a machine housing and a grinding system in the machine housing, wherein the grinding system comprises a cutting mechanism, a tooth plate rubbing mechanism and a hammer grinding mechanism; the cutting mechanism comprises movable cutters and fixed cutters of a main shaft; the fixed cutters and the movable cutters are arranged at an interval in sequence; the tooth plate rubbing mechanism comprises a barrel with rolling teeth on the outer circumferential surface and an oblique tooth plate arranged on the inner wall of the machine housing; the hammer grinding mechanism comprises a horizontal drive shaft, hammers arranged on the circumferential surface of the drive shaft at an interval and a sieve plate positioned below the drive shaft; openings are uniformly distributed in the sieve plate. The grinding machine is ...

System and method for providing augmented virtual reality content in autonomous vehicles

In one embodiment, a server receives a request from a first autonomous vehicle for content delivery. In response to the request, a vision analysis is performed on an image obtained from the request to determine three-dimensional (3D) positioning information of the image. A list of content items are identified based on current vehicle information of the first autonomous vehicle in view of a user profile of a user ridding the first autonomous vehicle. A first content item selected from the list of content items is augmented onto the image based on the 3D positioning information of the image, generating an augmented image. The augmented image is transmitted to the first autonomous vehicle, where the augmented image is to be displayed on a display device within the autonomous vehicle in a virtual reality manner.

HPHT rotoflector dynamic C neural network P0 tester

The utility model discloses a HPHT rotoflector dynamic C neural network P0 tester. The technical problem that the to be was solved provides a rotoflector corrosion fatigue testing arrangement who simulates the oil well tubular product under the actual working condition in oil field, provides the guidance at the performance research under the high -temperature and high -pressure dynamic behavior for oil well tubular product. The HPHT rotoflector dynamic C neural network P0 tester who adopts, including autoclave, circulation circuit, fixture, power unit, circulation circuit wherein at autoclave's both sides sealing connection to control mechanism and counting system, and fixture installs in the inside of kettle for fixed circular smooth sample, the outer power unit of kettle is being connected through the shaft in the side, and power unit will do all can to transmit and give the sample, make it be in the circumrotation condition, and rethread counting system and control mechanism pairing ...

Heater loop control method and system as well as heater loop

The invention discloses a heater loop control method which comprises steps as follows: the passing current of a heater is detected in real time, when the passing circuit is higher than a preset value, a work loop of the heater is opened; otherwise, the work loop of the heater is closed; when the work loop cannot be opened, secondary protection is started. With the adoption of the technical scheme, the passing current passing through the heater is detected, the work loop of the heater is controlled to be in an automatically opened or automatically closed state, when automatic opening fails, secondary protection is started, so that the running safety and reliability of the heater loop are improved, and engine failures are reduced. The invention further discloses a system applying the control method as well as the heater loop.

Software upgrading method and device of electronic control unit, equipment and medium

The invention discloses a software upgrading method and device for an electronic control unit, equipment and a medium. The method comprises the steps that after a software upgrading request corresponding to the electronic control unit is received, whether the electronic control unit meets a software upgrading condition or not is detected; after it is detected that the electronic control unit meets the software upgrading condition, a software upgrading file corresponding to the electronic control unit is obtained from an upgrading server according to a preset communication protocol; upgrading the software of the electronic control unit according to the software upgrading file; after it is detected that software upgrading of the electronic control unit fails, a software upgrading script corresponding to the electronic control unit is obtained, and software of the electronic control unit is upgraded again according to the software upgrading script. According to the embodiment of the invention ...

ALCOHOL FUEL ALCOHOL CONTENT DETECTION METHOD AND MODULE

resumo o presente invento fornece um método e módulo de detecção do teor de álcool em álcool combustível. o método compreende as seguintes etapas: coleta teor de oxigênio o(n) no sistema de escape de automóveis; a obtenção de uma relação de ar-combustível ac(n) de acordo com o(n) e um teor de etanol pré-definido ap(n); a obtenção de um volume de injeção de combustível fc(n) de acordo com o ac(n) e uma entrada de ar no motor g; o cálculo do desvio de combustível fd(n)=[fc(n)-fp(n)]/ fp(n), em que f p(n) é uma quantidade predefinida de injeção de combustível; obtenção de um desvio do teor de etanol ad(n) de acordo com fd(n); o cálculo do teor de etanol atual de ar(n)=ad(n)+ap(n); altera ap(n+1); e obtenção uma quantidade de injeção de combustível atual fr(n) de acordo com ar(n); alteração de fr(n+1); injeção do combustível de acordo com a quantidade fr(n) , e as referidas etapas de circulação; quando o valor absoluto de fd(n) for inferior a um valor de desvio de combustível estável s, parar a circulação. o método de detecção do teor de álcool de álcool combustível de acordo com a presente invenção pode detectar o teor de etanol no combustível, e melhorar o desempenho da utilização de veículos de combustível.

Piperidine derivatives as orexin receptor antagonist

The present invention discloses a series of piperidine derivatives as orexin receptor antagonists and compositions thereof, and relates to the application thereof in preparing medications for the treatment of insomnia, chronic obstructive pulmonary disease, obstructive sleep apnea, hypersomnia, anxiety, obsessive-compulsive disorder, panic attack, nicotine addiction, or binge eating disorder.

Device and method for automatically and flexibly loading cigarettes in side-opening cigarette case

The invention discloses an automatic flexible cigarette loading device and method for a side-opening cigarette case, and relates to the technical field of tobacco packaging machinery. Comprising a mounting base, a plurality of intermittent conveying belts are arranged on the mounting base, and a cigarette case uncovering mechanism and a lining paper opening mechanism which are used for conducting pretreatment on cigarette cases are sequentially arranged on the mounting base in the conveying direction of the intermittent conveying belts. The follow-up dip angle cigarette bundle conveying mechanism is used for realizing flexible cigarette loading; the flexible cigarette boxing mechanism is used for pushing and arranging cigarettes; cigarette boxes are automatically supplied and conveyed through the gap conveying belt, the cigarette boxes are automatically opened through the cigarette box uncovering mechanism and the lining paper opening mechanism, and then the cigarette bundles are filled ...

Formation method and application of lithium manganese iron phosphate soft package battery

The invention provides a formation method and application of a lithium manganese iron phosphate soft package battery, and relates to the field of lithium ion batteries. The formation method is carried out under high-temperature and high-pressure conditions and comprises the following steps: firstly, standing the lithium manganese iron phosphate soft package battery subjected to liquid injection and aging for the first time, then, carrying out constant-current charging on the battery until the SOC is 10-30%, standing for the second time, then, carrying out constant-current charging on the battery until the SOC is 20-40%, standing for the third time, and then, carrying out constant-current and constant-voltage charging on the battery until the SOC is 100%. According to the formation method, the lithium manganese iron phosphate soft package battery can achieve a relatively optimized formation effect which is specifically reflected in that the first-time efficiency, the normal-temperature capacity ...

Hybrid vehicle battery system

The utility model belongs to the technical field of car control, a hybrid vehicle battery system is provided, including power module for stepping up of hybrid vehicle's load end voltage, collection module for gather the battery package terminal voltage and the load end voltage of battery package, control module for the electricity generation of control power module is perhaps closed, the major loop for the circuit of load power supply, power module, collection module and major loop respectively with control module signal connection, the load of power module and major loop is parallelly connected, control module perhaps closes according to collection module's information control power module's electricity generation to switch -on of control major loop or disconnection. The utility model aims at providing a hybrid vehicle battery system increases power module, and through power module promotion load end voltage, the preliminary filling return circuit is saved in the switch -on and the disconnection ...

Advanced back side process fabrication method for improving IGBT performance

The invention discloses an advanced back side process fabrication method for improving IGBT performance. The method comprises the steps that: (1) after an IGBT front side process is completed, the backside of a wafer is thinned, and then donor impurity ions are implanted into the back side of the wafer; (2) laser annealing is conducted to the back side of the wafer to activate the donor impurity ions implanted in the back side, so that an N type buffer layer serving as a field stop is formed; (3) acceptor impurity ions are implanted into the back side of the wafer; (4) laser annealing is conducted to the back side of the wafer to activate the acceptor impurity ions implanted in the back side, so that a P type collector layer serving as a collector is formed. By means of the method, the better 'figure of merit' matching between the pressure endurance and pressure drop breakover of an IGBT is achieved, and due to the fact that the electric current density of the IGBT is increased, the device ...

Water purifier with adjustable TDS value

The invention relates to a water purifier with an adjustable TDS (total dissolved solids) value, which comprises a water inlet 1, a water outlet 2, a primary filter 3 and a secondary filter 4, the primary filter 3 and the secondary filter 4 have a water filtering function, the water inlet end of the primary filter 3 is connected with the water inlet 1, and the water outlet end of the primary filter 3 is connected with the water inlet end of the secondary filter 4. The water outlet end of the first-stage filter 3 is connected with the water outlet end of the second-stage filter 4 and is connected with the water inlet end of the water outlet 2 through a water mixing pipeline, and the water inlet end of the water outlet 2 is connected with a regulating valve mechanism which is used for regulating the flow proportion of water flowing to the water mixing pipeline through the water outlet end of the first-stage filter 3 and the water flow proportion of water flowing to the water mixing pipeline ...

Incinerator box body for household garbage treatment

The utility model discloses an incinerator box body for household garbage treatment. Relates to the technical field of household garbage treatment equipment. The structure is reasonable, the heat insulation effect is good, scalding can be effectively prevented, and the energy utilization rate is increased. Comprising a body, the outer wall of the body is wrapped with a heat insulation layer, a first clamping sleeve and a second clamping sleeve are sequentially arranged outside the heat insulation layer, cooling water is contained in the first clamping sleeve, and air is introduced into the second clamping sleeve; a water inlet pipe and an air inlet pipe are further arranged outside the body, the water inlet pipe is communicated with a water source and the first clamping sleeve, the air inlet pipe is communicated with an air source and the second clamping sleeve, and the air inlet pipe is arranged in the water inlet pipe in a penetrating mode. The water flow direction in the section, wrapping ...

PIPERIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONIST

Measuring tool

The invention provides a measuring tool used for measuring a deformation size of a wafer boat box relative to a standard shape, wherein the wafer boat box comprises an accommodating part provided with an opening. The measuring tool comprises a first measuring part and a second measuring part, wherein the first measuring part is matched with the standard shape of the accommodating part of the wafer boat box and used for measuring the deformation condition of the accommodating part of the wafer boat box; and the second measuring part is connected with the first measuring part and used for measuring the size of the opening of the accommodating part of the wafer boat part. The measuring tool can quickly and accurately detect whether the wafer boat box is deformed or not and whether the deformation size is in an acceptable range or not, and the measuring tool is not influenced by artificial errors and measuring locations. When different survey crew measure the same wafer boat box to be measured ...

System and method for providing inter-vehicle communications amongst autonomous vehicles

In one embodiment, a vehicle identifier (ID) and vehicle information of a first autonomous vehicle is transmitted to a cloud server over a network, where the cloud server is communicatively coupled to a plurality of autonomous vehicles. A list of one or more vehicle identifiers (IDs) are received from the cloud server. The vehicle IDs identify one or more autonomous vehicles are within a predetermined geographic proximity of the first autonomous vehicle. The first autonomous vehicle communicates with a second autonomous vehicle that is selected from the list of one or more autonomous vehicles via a wireless local area network to exchange an operational status of the first autonomous vehicle with the second autonomous vehicle.

Extracting norfibroase from snake venom and preparation process for liquid drugs injection of norfibroase

The invention discloses a method of extracting defibrase from snake poison and preparing defibrase injection preparation, and the process of extracting defibrase includes the steps: preparing monoclonal antibody; preparing crude defibrase; preparing antibody affinity chromatography column; preparing defibrase; and the process of preparing the defibrase injection preparation includes the steps: taking and adding purified defibrase to a proper amount of injection water for dissolving so as to obtain a solution, adding 5-20g NaCl stabilizer to every 1000ml solution, making split charging and obtaining the defibrase injection preparation.

Gate structure of IGBT (insulated gate bipolar transistor) device

The invention discloses a gate structure of an IGBT (insulated gate bipolar transistor) device. The IGBT device is formed by a plurality of IGBT unit structures in parallel, and each IGBT unit structure comprises a gate unit; the gate units are parallelly connected in a net structure to form one or more groups of gate parallel structures, and the gate parallel structures are parallelly connected to form the gate structure; the gate units in the gate parallel structures are strip shaped and in parallel arrangement and serve as bottom levels of the gate parallel structures, the plurality of adjacent gate units are parallelly connected to serve as a subunit one level above the corresponding bottom level, and the plurality of adjacent subunits, in each corresponding level, of the gate parallel structures are parallelly connected together to serve as a subunit one level above the corresponding level; top levels of the gate parallel structures of the gate structure are connected together to connect ...

Handheld bathymetric survey device

The invention discloses a handheld bathymetric survey device which is characterized by comprising a handle, wherein a shaft sleeve is arranged at the front end of the handle; a rotating shaft is rotationally connected in the shaft sleeve; the rotating shaft can drive a cylindrical shell to rotate; an angle dial which can rotate relative to the shell and is marked with angle degrees is arranged on the round surface of the outer end of the shell; a rocking button which can drive the shell to rotate is arranged on the outer circumference on the round surface of the outer end; scale marks and a plumb line are connected with the rotating shaft; the tail end of the scale marks is connected with a sinker ball; the tail end of the plumb line is connected with a plumb; the scale marks, the plumb line, the sinker ball and the plumb are positioned in the inner cavity of the shell; a cover which can close the inner cavity is arranged on the shell; and a lift type locking button of which the bottom ...

Silicon bulk evolution home roll

The utility model relates to a silicon bulk evolution home roll, the flexible of cutting copper wire self has been brought to the rotation difference of having solved between the wire wheel, influences cutting copper wire life's defect, the roller that supports including both ends, the roller is monolithic structure, and a plurality of evolution moulds have been put to fixed cover on the roller, and the interval between the evolution mould is set for according to silicon bulk evolution size. Fixed evolution mould on the roller, all evolution moulds are synchronous to rotate, steady when ensureing to cut the copper wire quick travel to guarantee cutting copper wire life.

Automatic annealing test system and method for photovoltaic batteries

The invention discloses an automatic annealing test system for photovoltaic batteries. The automatic annealing test system comprises a support device, a simulation light source, a temperature regulation unit, a control device and a current/voltage module, wherein the support device is used for carrying a tested battery, the simulation light source is used for providing light for the tested battery, the temperature regulation unit is used for regulating temperature for the tested battery and comprises a heating module, the control device is connected with the temperature regulation unit, and the current/voltage module is connected between the tested battery and the control device. Both the simulation light source and the temperature regulation unit are fixedly connected with the support device. The invention further discloses an automatic annealing test method for the photovoltaic batteries. The automatic annealing test system is simple in structure, easy to assemble and maintain and convenient ...

Solar cell life test system

The application discloses solar cell life test system includes: the glove box has the airtight cavity that provides the inert atmosphere environment for the solar cell test, test light source, set up in the outside of the airtight cavity of glove box is equipped with the transparent window that supplies light to get into between this test light source and the airtight cavity. This neotype test system can reduce the influence to unencapsulated exposed device by furthest, test light source sets up in airtight cavity outsidely, can improve light source stability nature, can automatically detect and statistical analysis a plurality of solar cell device parameters.

Derivados de piperidina como antagonista de receptores de orexina

<p>COMPUESTOS DERIVADOS DE PIPERIDINA, ANTAGONISTAS DE RECEPTORES DE OREXINA; COMPOSICION FARMACEUTICA QUE LOS COMPRENDE Y EL USO EN ENFERMEDADES TALES COMO EPOC, TRASTORNO OBSESIVO COMPULSIVO, ANSIEDAD, ENTRE OTRAS.</p> <p> PIPERIDINE DERIVATIVE COMPOUNDS, OREXINE RECEIVER ANTAGONISTS; PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND THE USE IN DISEASES SUCH AS COPD, COMPULSIVE OBSESSIVE DISORDER, ANXIETY, AMONG OTHERS. </p>

Multi -functional heavy metal detector

The utility model discloses a multi -functional heavy metal detector, including detection device and casing, detection device installs in the casing, and detection device includes FPGA module, display device, keyboard device, heavy metal detection module, alarm module and power module, and keyboard device, heavy metal detection module and power module are connected to the input of FPGA module, and display device and alarm module are connected to its output, the casing includes face -piece and drain pan, and the face -piece is equipped with an inferior gram force board corresponding to display device's position department, and the ya keli board passes through the marine glue to be fixed on the face -piece, and the face -piece is equipped with a waterproofing membrane corresponding to the position department of keyboard device, and the back of drain pan is equipped with the polycrystalline silicon solar cell board, and power module is connected to the polycrystalline silicon solar cell board ...

Take rain water collecting device's cowshed

The utility model discloses take rain water collecting device's cowshed belongs to cowshed equipment field, the technical problem that will solve provides take rain water collecting device's cowshed, adopts slanted type's ceiling, and is equipped with the recess rainwater on the ceiling and can leaves along with the recess, flows in the side canopy from main canopy, and the edge of side canopy is equipped with the water catch bowl, and the rainwater amasss in the water catch bowl to flow in the cistern through the aqueduct, the problem of this technique is solved the technical scheme who adopts does: take rain water collecting device's cowshed, including ceiling and water -collection device, the ceiling includes main canopy and side canopy, the lower part is fixed with the first bracing piece that is used for supporting main canopy, open the middle part of main canopy has light transmission groove, light transmission groove's top is equipped with the canopy that shelters from that is used ...

Genes Conferring Drought and Salt Tolerance and Uses Thereof

Compositions and methods for conferring drought and salt tolerance to plants using tocopherol cyclase (TC) genes, including polynucleotides, polypeptides, vectors, cells and plants.

METHOD OF FABRICATING P-TYPE SURFACE-CHANNEL LDMOS DEVICE WITH IMPROVED IN-PLANE UNIFORMITY

A method of fabricating a P-type surface-channel laterally diffused metal oxide semiconductor device includes forming a gate structure with polysilicon and metal silicide, and the processes of channel implantation, long-time high-temperature drive-in, formation of a heavily doped N-type polysilicon sinker and boron doping of a polysilicon gate, are performed in this order, thereby ensuring the gate not to be doped with boron during its formation. The high-temperature drive-in process is allowed to be carried out to form a channel with a desired width, and a short channel effect which may cause penetration or electric leakage of the resulting device is prevented. As the polysilicon gate is not processed by any high-temperature drive-in process after it is doped with boron, the penetration of boron through a gate oxide layer and the diffusion of N-type impurity contained in the heavily doped polysilicon sinker into the channel or other regions are prevented. 1. A method of fabricating a P-type surface-channel laterally diffused metal oxide semiconductor (LDMOS) device , comprising the following steps in the sequence set forth:step a) sequentially growing an N-type epitaxial region and a gate oxide layer over an N-type substrate and depositing a non-doped polysilicon layer over the gate oxide layer;step b) etching the non-doped polysilicon layer to form a polysilicon gate and performing an N-type ion implantation with a portion of the polysilicon gate and a portion of the gate oxide layer, both on a first side of the polysilicon gate, covered with a photoresist, wherein an energy of the N-type ion implantation is controlled to make the implanted ions not penetrate through the polysilicon gate;step c) removing the photoresist and performing a first P-type ion implantation, followed by a high-temperature drive-in process, thereby forming a first lightly doped drain drift diffusion region in a portion of the N-type epitaxial region on the first side of the polysilicon ...

Molecular assessment of trbc usage

The invention relates to a method of determining the T cell receptor β chain (TRBC) gene type of a cell, the method comprising (a) determining the J gene type expressed in said cell, and (b) inferring from (a) the TRBC gene type expressed in said cell. The invention further relates to use of a CAR T cell targeted to a T cell receptor β chain (TRBC) type 1, or a CAR T cell targeted to a T cell receptor β chain (TRBC) type 2. The invention further relates to a method of medical treatment, and to nucleic acid probes.

CHIMERIC ANTIGEN RECEPTOR

The present invention provides a chimeric antigen receptor (CAR) which binds a low density target antigen, which comprises a Fab antigen binding domain. The invention also relates to cells expressing such a CAR and their use in the treatment of disease. 1. A chimeric antigen receptor (CAR) which binds B cell maturation antigen (BCMA) , wherein the CAR comprises a Fab antigen binding domain.24-. (canceled)6. A CAR according to claim 5 , wherein the Fab antigen-binding domain comprises a VH domain having the sequence shown as SEQ ID No. 29; and a VL domain having the sequence shown as SEQ ID No. 30.7. A CAR according to wherein the Fab antigen-binding domain comprises a first binding domain which binds a first target antigen and a second binding domain which binds a second target antigen.8. (canceled)9. A CAR according to claim 7 , which comprises a cleavable linker between the first and second binding domains.10. A CAR according to claim 9 , wherein the linker is cleavable with a matrix metalloproteinase (MMP).11. A nucleic acid sequence which encodes a CAR according to .12. A nucleic acid construct which encodes a CAR according to and has one of the following general structures:VH-CH-spacer-TM-endo-coexpr-VL-CL;VL-CL-coexpr-VH-CH-spacer-TM-endo;VL-CL-spacer-TM-endo-coexpr-VH-CH; orVH-CH-coexpr-VL-CL-spacer-TM-endo;in which:VH is a nucleic acid sequence encoding a heavy chain variable region;CH is a nucleic acid sequence encoding a heavy chain constant region spacer is a nucleic acid encoding a spacer;TM is a nucleic acid sequence encoding a transmembrane domain;endo is a nucleic acid sequence encoding an endodomain;coexpr is a nucleic acid sequence enabling co-expression of the first and second polypeptides;VL is a nucleic acid sequence encoding a light chain variable region; andCL is a nucleic acid sequence encoding a light chain constant region.13. A nucleic acid construct which encodes a CAR according to and has one of the following general structures:VH1-L1-VH2- ...

Obstacle detection systems

Virtual bumpers for autonomous vehicles improve effectiveness and safety as such vehicles are operated. One or more sensor systems having a Lidar sensor and a camera sensor determine proximity of objects around the vehicle and facilitate identification of the environment around the vehicle. The sensor systems are placed at various locations around the vehicle. The vehicle identifies an object and one or more properties of the identified object using the sensor systems. Based on the identified object and the properties of the object, a virtual bumper may be created for that object. For example, if the object is identified as another vehicle moving with a certain velocity, the vehicle may determine a minimum space to avoid the other vehicle, either by changing direction or reducing the velocity of the vehicle, with the minimum space constituting a virtual bumper.

WATERBORNE POLYURETHANE DISPERSION AND METHOD FOR PREPARING THE SAME

Provided is a waterborne polyurethane dispersion. The waterborne polyurethane dispersion is prepared in the presence of a hydrophilic amino siloxane compound and exhibits good anti-stickiness while retaining superior mechanical properties. A laminated synthetic leather article prepared with said waterborne polyurethane dispersion as well the method for preparing the synthetic leather article are also provided. 2. The waterborne polyurethane dispersion according to claim 1 , wherein there is no cationic or anionic hydrophilic pendant groups or groups which can be converted into the cationic or anionic hydrophilic pendant groups covalently attached to the backbone chain of polyurethane in the polyurethane particles claim 1 , and the polyurethane is externally emulsified.3. The waterborne polyurethane dispersion according to claim 1 , wherein the one or more compounds having at least two isocyanate groups are selected from the group consisting of:a) C4-C12 aliphatic polyisocyanates comprising at least two isocyanate groups, C6-C15 cycloaliphatic or aromatic polyisocyanates comprising at least two isocyanate groups, C7-C15 araliphatic polyisocyanates comprising at least two isocyanate groups, and a combination thereof; andb) an isocyanate prepolymer prepared by reacting one or more polyisocyanates of a) with one or more isocyanate-reactive components selected from the group consisting of C2-C16 aliphatic polyhydric alcohols comprising at least two hydroxy groups, C6-C15 cycloaliphatic or aromatic polyhydric alcohols comprising at least two hydroxy groups, C7-C15 araliphatic polyhydric alcohols comprising at least two hydroxy groups, polyester polyols having a molecular weight from 500 to 5,000, polycarbonate diols having a molecular weight from 200 to 5,000, polyetherdiols having a molecular weight from 200 to 5,000, C2 to C10 polyamine comprising at least two amino groups, C2 to C10 polythiol comprising at least two thiol groups, C2-C10 alkanolamine comprising at least ...

Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same

The invention relates to polynucleotides, particularly chimeric polynucleotides useful for optimal production of functional immunoglobulins with human idiotypes in rodents. The invention further relates to rodents comprising such polynucleotides.

Obstacle detection systems

Virtual bumpers for autonomous vehicles improve effectiveness and safety as such vehicles are operated. One or more sensor systems having a Lidar sensor and a camera sensor determine proximity of objects around the vehicle and facilitate identification of the environment around the vehicle. The sensor systems are placed at various locations around the vehicle. The vehicle identifies an object and one or more properties of the identified object using the sensor systems. Based on the identified object and the properties of the object, a virtual bumper may be created for that object. For example, if the object is identified as another vehicle moving with a certain velocity, the vehicle may determine a minimum space to avoid the other vehicle, either by changing direction or reducing the velocity of the vehicle, with the minimum space constituting a virtual bumper.

ANTIBODY-INTERLEUKIN FUSION PROTEIN AND METHODS OF USE

Provided is a protein comprising an antibody or antigen-binding fragment and an interleukin molecule operably linked to the antibody or antigen-binding fragment. The antibody or antigen-binding fragment specifically binds to an immune checkpoint protein. The interleukin molecule is IL-10. 1. A protein comprising: (1) a heavy chain variable domain, and', '(2) a light chain variable domain; and, '(a) an antibody or antigen binding fragment specifically binds to an immune checkpoint protein, said antibody or antigen-binding fragment comprising'}(b) an interleukin-10 (IL-10) molecule operably linked to the antibody or antigen-binding fragment.2. The protein of claim 1 , wherein the immune checkpoint protein is PD-1 or PD-L1.3. The protein of claim 1 , wherein the antibody comprises a Fc region.4. The protein of claim 1 , wherein the antigen-binding fragment is an F(ab′)2 fragment or a single chain variable fragment (scFv).5. The protein of claim 1 , wherein the antibody or antigen-binding fragment comprises (1) a heavy chain comprising the heavy chain variable domain and (2) a light chain comprising the light chain variable domain.6. The protein of claim 5 , wherein the IL-10 molecule is linked to the heavy chain.7. The protein of claim 6 , wherein the IL-10 molecule is linked to C-terminal of the heavy chain.8. The protein of claim 5 , wherein the IL-10 molecule is linked to the light chain.9. The protein of claim 8 , wherein the IL-10 molecule is linked to C-terminal of the light chain.10. The protein of claim 1 , further comprising a linker that links the antibody or antigen-binding fragment thereof and the interleukin molecule.11. The protein of claim 10 , wherein the linker comprising the amino acid sequence (GGGGS)n (n=2-5).12. An isolated polynucleotide encoding the protein of .13. A vector capable of expressing a protein claim 12 , comprising the isolated polynucleotide of .14. A recombinant host cell suitable for producing a protein claim 13 , comprising the ...

HUMAN ANTIBODIES FROM TRANSGENIC RODENTS WITH MULTIPLE HEAVY CHAIN IMMUNOGLOBULIN LOCI

The invention relates to transgenic animals useful for optimal production of functional immunoglobulins with human idiotypes. 1. A transgenic animal comprising at least one inactivated endogenous Ig locus and a plurality of artificial transgenic Ig heavy chain loci integrated in the animal's genome at different chromosomal sites.2. The transgenic animal according to claim 1 , wherein the plurality of artificial Ig heavy chain loci comprise (i) a V-region having at least one human V gene segment encoding a germline or hypermutated human V-region amino acid sequence; (ii) one or more J gene segments; and (iii) one or more constant region gene segments claim 1 , wherein said artificial Ig heavy chain loci are functional and capable of undergoing gene rearrangement and act cooperatively to produce a repertoire of artificial immunoglobulins.3. The transgenic animal of claim 2 , wherein the at least two artificial Ig heavy chain loci comprise the full complement of human variable heavy chain regions between them claim 2 , wherein said artificial heavy chain loci optionally comprise overlapping heavy chain gene segments.4. (canceled)5. The transgenic animal according to claim 1 , wherein said transgenic animal lacks one of the following: a functional endogenous Ig light chain locus claim 1 , or a functional endogenous Ig heavy chain locus.6. (canceled)7. The transgenic animal according to claim 1 , wherein said transgenic animal expresses a diverse repertoire of antibodies encoded by V-genes from transgenic immunoglobulin loci located at different chromosomal sites claim 1 , wherein said transgenic animal optionally lacks a functional Ig light chain locus and is capable of producing heavy chain-only antibodies.8. (canceled)9. The transgenic animal of claim 2 , wherein at least one of the artificial Ig heavy chain loci comprises at least one human immunoglobulin (Ig) joining (J) region gene claim 2 , an Ig constant region gene claim 2 , and a rat 3′ enhancer claim 2 , said ...

POLYNUCLEOTIDES ENCODING RODENT ANTIBODIES WITH HUMAN IDIOTYPES AND ANIMALS COMPRISING SAME

The invention relates to polynucleotides, particularly chimeric polynucleotides useful for optimal production of functional immunoglobulins with human idiotypes in rodents. The invention further relates to rodents comprising such polynucleotides. 1. A chimeric polynucleotide comprising at least one human immunoglobulin (Ig) joining (J) region gene , an Ig constant region gene , and a rat 3′ enhancer.2. The chimeric polynucleotide of claim 1 , wherein said rat 3′ enhancer comprises he sequence set forth as SEQ ID NO:1.3. The chimeric polynucleotide of claim 1 , further comprising at least one human Ig variable (V) region gene and/or a human Ig diversity (D) region gene.4. The chimeric polynucleotide of claim 1 , wherein the constant region gene is selected from the group consisting of a human constant region gene and a rat constant region gene.5. The chimeric polynucleotide of claim 1 , wherein the constant region gene comprises a rat constant region gene.6. The chimeric polynucleotide of claim 1 , wherein the constant region gene comprises a constant region gene selected from the group consisting of Cμ and Cγ.7. The chimeric polynucleotide of claim 1 , comprising a nucleic acid sequence substantially homologous to bacterial artificial chromosome (BAC) Annabel claim 1 , or a portion thereof.8. The chimeric polynucleotide of claim 3 , wherein said human Ig V region comprises at least one human V region gene isolatable from BAC6-V3-11 and/or BAC3.9. The chimeric polynucleotide of claim 1 , comprising nucleic acid sequences (a) and (b) in 5′ to 3′ order:{'sub': 'H', '(a) a human Ig variable region comprising human V region genes in natural configuration isolatable from BAC6-V3-11 and/or BAC3; and'}(b) a human Ig joining region comprising human J region genes in natural configuration isolatable from the bacterial artificial chromosome (BAC) Annabel.10a.. The chimeric polynucleotide of claim 3 , wherein each of the human immunoglobulin variable region claim 3 , the human ...

PIPERIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONIST

The present invention discloses a series of piperidine derivatives as orexin receptor antagonists and compositions thereof, and relates to the application thereof in preparing medications for the treatment of insomnia, chronic obstructive pulmonary disease, obstructive sleep apnea, hypersomnia, anxiety, obsessive-compulsive disorder, panic attack, nicotine addiction, or binge eating disorder. 6. The compound of or the pharmaceutically acceptable salt thereof claim 1 , wherein the 5-6 membered cyclohydrocarbyl or heterocyclic group are each independently selected from phenyl claim 1 , pyridyl claim 1 , furyl claim 1 , thienyl claim 1 , thiazolyl claim 1 , pyrimidinyl claim 1 , pyrazolyl claim 1 , 1 claim 1 ,2 claim 1 ,3-triazolyl or 1 claim 1 ,2 claim 1 ,5-triazolyl.11. The compound of or the pharmaceutically acceptable salt thereof claim 1 , wherein Y is selected from —CH—O-E or —O-E claim 1 , wherein E is defined as in .15. The compound of or the pharmaceutically acceptable salt thereof claim 1 , wherein U claim 1 , X claim 1 , and G are independently selected from NH or N—Calkyl.16. The compound of or the pharmaceutically acceptable salt thereof claim 1 , wherein R claim 1 , R claim 1 , and Rare independently selected from H claim 1 , methyl claim 1 , or fluoro.17. The compound of or the pharmaceutically acceptable salt thereof claim 1 , wherein Rand Rare independently selected from H claim 1 , methyl claim 1 , fluoro or cyclopropyl.18. The compound of or the pharmaceutically acceptable salt thereof claim 1 , wherein Rand Rtogether form 3-8 membered cycloalkyl;{'sub': 2', '3, 'specifically, Rand Rtogether form a cyclopropyl.'}19. The compound of or the pharmaceutically acceptable salt thereof claim 1 , wherein Calkyl is selected from methyl claim 1 , ethyl claim 1 , propyl claim 1 , butyl claim 1 , pentyl claim 1 , or hexyl claim 1 , wherein propyl claim 1 , butyl claim 1 , pentyl claim 1 , or hexyl is optionally cyclized or partially cyclized.21. A pharmaceutical ...

SYSTEM AND METHOD FOR PROVIDING INTER-VEHICLE COMMUNICATIONS AMONGST AUTONOMOUS VEHICLES

A cloud server maintains a neighboring vehicle data structure storing vehicle information of vehicles coupled to the cloud server over a network. The server receives a first request from a first of the vehicles, including a first vehicle identifier (ID) and current vehicle metadata of the first vehicle. In response to the first request, the server traverses the neighboring vehicle data structure to update a first node corresponding to the first vehicle based on the first vehicle ID and the current vehicle information of the first vehicle. The server transmits to the first vehicle over the network a list of one or more vehicle IDs identifying one or more vehicles that are within a predetermined geographic proximity of the first autonomous vehicles to allow the first vehicle to directly communicate with any vehicle in the list via a wireless local area network. 1. A non-transitory machine-readable medium having instructions stored therein , which when executed by a processor , cause the processor to perform operations of managing statuses of autonomous vehicles , the operations comprising:maintaining at a cloud server a neighboring vehicle data structure storing vehicle metadata of a plurality of autonomous vehicles communicatively coupled to the cloud server over a network;receiving a first update request from a first of the autonomous vehicles, the first update request including a first vehicle identifier (ID) and current vehicle metadata of the first autonomous vehicle;in response to the first update request, traversing the neighboring vehicle data structure to update a first node corresponding to the first autonomous vehicle based on the first vehicle ID and the current vehicle metadata of the first autonomous vehicle;identifying one or more autonomous vehicles that are within a predetermined geographic proximity of the first autonomous vehicle using a neighbor search algorithm; andtransmitting to the first autonomous vehicle over the network a list of one or more ...

Methods and reagents for analysing nucleic acids from single cells

The present invention relates to a partition library which comprises a plurality of partitions which are useful for the analysis of the transcriptional response of a CAR to a target antigen. Further, the present invention relates to assays for the analysis of the transcriptional response of a CAR to a target antigen. The present invention also relates to kits comprising the plurality of partitions.

SYSTEM AND METHOD FOR PROVIDING AUGMENTED VIRTUAL REALITY CONTENT IN AUTONOMOUS VEHICLES

In one embodiment, a server receives a request from a first autonomous vehicle for content delivery. In response to the request, a vision analysis is performed on an image obtained from the request to determine three-dimensional (3D) positioning information of the image. A list of content items are identified based on current vehicle information of the first autonomous vehicle in view of a user profile of a user ridding the first autonomous vehicle. A first content item selected from the list of content items is augmented onto the image based on the 3D positioning information of the image, generating an augmented image. The augmented image is transmitted to the first autonomous vehicle, where the augmented image is to be displayed on a display device within the autonomous vehicle in a virtual reality manner. 1. A computer-implemented method for content delivery to autonomous vehicles , the method comprising:receiving at a server a request from a first autonomous vehicle for content delivery;in response to the request, performing a vision analysis on an image obtained from the request to determine three-dimensional (3D) positioning information of the image;identifying a list of a plurality of content items based on current vehicle information of the first autonomous vehicle in view of a user profile of a user ridding the first autonomous vehicle;augmenting a first content item selected from the list of content items onto the image based on the 3D positioning information of the image, generating an augmented image; andtransmitting the augmented image to the first autonomous vehicle, wherein the augmented image is to be displayed on a display device within the autonomous vehicle in a virtual reality manner.2. The method of claim 1 , wherein the server provides content delivery to a plurality of autonomous vehicle over a network.3. The method of claim 1 , wherein the image was captured in real-time by one or more cameras of the first autonomous vehicle representing a ...

SYSTEM AND METHOD FOR PROVIDING INTER-VEHICLE COMMUNICATIONS AMONGST AUTONOMOUS VEHICLES

In one embodiment, a vehicle identifier (ID) and vehicle information of a first autonomous vehicle is transmitted to a cloud server over a network, where the cloud server is communicatively coupled to a plurality of autonomous vehicles. A list of one or more vehicle identifiers (IDs) are received from the cloud server. The vehicle IDs identify one or more autonomous vehicles are within a predetermined geographic proximity of the first autonomous vehicle. The first autonomous vehicle communicates with a second autonomous vehicle that is selected from the list of one or more autonomous vehicles via a wireless local area network to exchange an operational status of the first autonomous vehicle with the second autonomous vehicle. 1. A computer-implemented method for inter-vehicle communications amongst autonomous vehicles , the method comprising:transmitting a vehicle identifier (ID) and vehicle information of a first autonomous vehicle to a cloud server over a network, wherein the cloud server is communicatively coupled to a plurality of autonomous vehicles;receiving a list of one or more vehicle identifiers (IDs) from the cloud server, the vehicle IDs identifying one or more autonomous vehicles are within a predetermined geographic proximity of the first autonomous vehicle; andcommunicating with a second autonomous vehicle that is selected from the list of one or more autonomous vehicles via a wireless local area network to exchange an operational status of the first autonomous vehicle with the second autonomous vehicle.2. The method of claim 1 , wherein the autonomous vehicles of the list were identified by the cloud server based on location information of the first autonomous vehicle and location information of the one or more autonomous vehicles.3. The method of claim 2 , wherein the cloud server maintains a neighboring vehicle data structure storing geographic neighboring information of the plurality of autonomous vehicles based on their respective vehicle ...

CHIMERIC ANTIGEN RECEPTOR

The present invention provides a cell comprising first and second chimeric antigen receptors (CARs), which bind to different antigens, wherein the first CAR binds to Transmembrane activator and calcium modulator and cyclophilin ligand (CAML) interactor (TACI). The present invention also provides a cell comprising a tan CAR comprising first and second antigen-binding domains which bind to different antigens, wherein the first antigen binding domain binds the antigen Transmembrane activator and calcium modulator and cyclophilin ligand (CAML) interactor (TACI). The present invention further provides corresponding nucleic acid sequences and/or constructs, kits and vectors comprising said nucleic acid sequences and/or constructs, molecules and methods for making such cells. The cells may be used in cellular immunotherapy approaches for treating diseases such as multiple myeloma. 1. A cell comprising first and second chimeric antigen receptors (CARs) , which bind to different antigens , wherein the first CAR binds to Transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI).2. A cell according to where the second CAR binds BCMA.3. A cell comprising a tanCAR comprising first and second antigen-binding domains which bind to different antigens claim 1 , wherein the first antigen binding domain binds the antigen Transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI).4. A cell according to where the second antigen binding domain binds to BCMA.5. A nucleic acid sequence encoding a tanCAR as defined in or .6. A nucleic acid sequence according to claim 5 , which has the following structure:AgB1-linker-AgB2-spacer-TM-endoin whichAgB1 is a nucleic acid sequence encoding the first antigen-binding domain of the tanCAR;linker is a nucleic acid sequence encoding a linker of the tanCAR;AgB2 is a nucleic acid sequence encoding the second antigen binding domain of the tanCAR;spacer is a nucleic acid sequence encoding a spacer of ...

CHIMERIC ANTIGEN RECEPTOR

The present invention provides a chimeric antigen receptor (CAR) which binds a low density target antigen, which comprises a Fab antigen binding domain. The invention also relates to cells expressing such a CAR and their use in the treatment of disease. 117-. (canceled)18. A cytolytic immune cell which expresses:a) a first chimeric antigen receptor (CAR) which binds B cell maturation antigen (BCMA), wherein the BCMA CAR comprises a Fab antigen binding domain comprising the VH domain of SEQ ID NO: 29 and the VL domain of SEQ ID NO: 30; andb) a second CAR which binds CD19, wherein the CD19 CAR comprises an scFv comprising the VH domain of SEQ ID NO: 67 and the VL domain of SEQ ID NO: 75.19. (canceled)20. A method for making a cell according to claim 18 , which comprises the step of introducing a nucleic acid or nucleic acids which express the CARs into a cell ex vivo.21. A pharmaceutical composition which comprises a plurality of cells according to claim 18 , together with a pharmaceutically acceptable carrier claim 18 , diluent or excipient.22. A method for treating multiple myeloma which comprises the step of administering a pharmaceutical composition according to to a subject.2325-. (canceled) This is a continuation of U.S. application Ser. No. 17/279,874 filed Mar. 25, 2021, which is the U.S. National Phase of International Application No. PCT/GB2019/052726 filed Sep. 26, 2019, which claims priority to Great Britain Application No. 1815775.0 filed Sep. 27, 2018 and Great Britain Application No. 1902021.3 filed Feb. 14, 2019.The present invention relates to chimeric antigen receptor (CAR) which binds to a low density target antigen such as B cell maturation antigen (BCMA).Multiple MyelomaMultiple Myeloma (myeloma) is a bone-marrow malignancy of plasma cells. Collections of abnormal plasma cells accumulate in the bone marrow, where they interfere with the production of normal blood cells. Myeloma is the second most common hematological malignancy in the U.S. (after ...

Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same

The invention relates to polynucleotides, particularly chimeric polynucleotides useful for optimal production of functional immunoglobulins with human idiotypes in rodents. The invention further relates to rodents comprising such polynucleotides.

Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same

The invention relates to polynucleotides, particularly chimeric polynucleotides useful for optimal production of functional immunoglobulins with human idiotypes in rodents. The invention further relates to rodents comprising such polynucleotides.

Human antibodies from transgenic rodents with multiple heavy chain immunoglobulin loci

The invention relates to transgenic animals useful for optimal production of functional immunoglobulins with human idiotypes.

MULTI-CHANNEL OBJECT MATCHING

A method may include obtaining first sensor data captured by a first sensor system and second sensor data captured by a second sensor system of a different type from the first sensor system. The method may include detecting a first object included in the first sensor data and a second object included in the second sensor data. The method may include assigning a first label to the first object and a second label to the second object after comparing the first and the second sensor data. The first and second labels may indicate degrees to which the first and the second objects match. Responsive to the first and second labels indicating that the first and the second objects match, the method may include designating a matched object representative of the first object and the second object and sending the matched object to a downstream computing system of an autonomous vehicle.

System and method of off-board-centric autonomous driving computation

An autonomous driving computing system may include an on-board computing system that is configured to perform first operations that include obtaining sensor data relating to an autonomous vehicle (AV). The first operations may include sending the obtained sensor data to an off-board cloud computing system. The autonomous driving computing system may include the off-board cloud computing system, which may be configured to perform second operations that include receiving the sensor data and performing computations relating to the driving operation of the AV based on the obtained sensor data. The second operations may include determining a control signal corresponding to a driving operation and sending the control signal to the on-board computing system. The first operations may involve the on-board computing system receiving, from the off-board cloud computing system, the control signal corresponding to the driving operation of the AV and performing the driving operation by implementing the control signal.

System and methods of adaptive trajectory prediction for autonomous driving

A method may include obtaining one or more inputs in which each of the inputs describes at least one of: a state of an autonomous vehicle (AV) or a state of an object; and identifying a prediction context of the AV based on the inputs. The method may also include determining a relevancy of each object of a plurality of objects to the AV in relation to the prediction context; and outputting a set of relevant objects based on the relevancy determination for each of the plurality of objects. Another method may include obtaining a set of objects designated as relevant to operation of an AV; selecting a trajectory prediction approach for a given object based on context of the AV and characteristics of the given object; predicting a trajectory of the given object using the selected trajectory prediction approach; and outputting the given object and the predicted trajectory.

System and method for providing inter-vehicle communications amongst autonomous vehicles

In one embodiment, a vehicle identifier (ID) and vehicle information of a first autonomous vehicle is transmitted to a cloud server over a network, where the cloud server is communicatively coupled to a plurality of autonomous vehicles. A list of one or more vehicle identifiers (IDs) are received from the cloud server. The vehicle IDs identify one or more autonomous vehicles are within a predetermined geographic proximity of the first autonomous vehicle. The first autonomous vehicle communicates with a second autonomous vehicle that is selected from the list of one or more autonomous vehicles via a wireless local area network to exchange an operational status of the first autonomous vehicle with the second autonomous vehicle.

Method for treating cancer patients using c-met inhibitor

Provided herein is related generally to the field of molecular biology and growth factor regulation. More specifically, provided herein are methods useful for treating cancer patient using c-Met inhibitor based on the identification of an increased c-Met expression and at least one c-Met gene alteration, e.g. c-Met mutation, c-Met fusion gene and c-Met gene amplification.

Multi-channel object matching

A method may include obtaining first sensor data captured by a first sensor system and second sensor data captured by a second sensor system of a different type from the first sensor system. The method may include detecting a first object included in the first sensor data and a second object included in the second sensor data. The method may include assigning a first label to the first object and a second label to the second object after comparing the first and the second sensor data. The first and second labels may indicate degrees to which the first and the second objects match. Responsive to the first and second labels indicating that the first and the second objects match, the method may include designating a matched object representative of the first object and the second object and sending the matched object to a downstream computing system of an autonomous vehicle.

Chimeric antigen receptor.

La presente invención provee un receptor antigénico quimérico (CAR) que se une a un antígeno objetivo en baja densidad, el cual comprende un dominio de unión a antígenos Fab. La invención también se refiere a células que expresan este CAR, y a su uso en el tratamiento de enfermedades.

System and method of adaptive distribution of autonomous driving computations

A method may include obtaining sensor data relating to an autonomous vehicle (AV) and a total measurable world around the AV. The method may include identifying an operating environment of the AV and determining a projected computational load for computing subsystems that facilitate a driving operation performable by the AV corresponding to the identified environment. The method may include off-loading first computing subsystems of the computing subsystems in which computations of the first computing subsystems may be processed by an off-board cloud computing system and processing computations associated with second computing subsystems of the computing subsystems by an on-board computing system. The method may include obtaining first computational results corresponding to the computations processed relating to the first computing subsystems and determining the driving operation of the AV based on the first computational results and second computational results corresponding to computations processed relating to the second computing subsystems.

Methods and reagents for analysing nucleic acids from single cells

The present invention relates to a partition library which comprises a plurality of partitions which are useful for the analysis of the transcriptional response of a CAR to a target antigen. Further, the present invention relates to assays for the analysis of the transcriptional response of a CAR to a target antigen. The present invention also relates to kits comprising the plurality of partitions.

High-definition mapping

A method may include obtaining sensor data about a total measurable world around an autonomous vehicle. The sensor data may be captured by sensor units co-located with the autonomous vehicle. The method may include generating a mapping dataset including the obtained sensor data and identifying data elements that each represents a point in the mapping dataset. The method may include sorting the data elements according to a structural data categorization that is a template for a high-definition map of the total measurable world and determining a mapping trajectory of the autonomous vehicle. The mapping trajectory may describe a localization and a path of motion of the autonomous vehicle. The method may include generating the high-definition map based on the structural data categorization and relative to the mapping trajectory of the autonomous vehicle, and the high-definition map may be updated based on the path of motion of the autonomous vehicle.

High-definition mapping

A method may include obtaining sensor data about a total measurable world around an autonomous vehicle. The sensor data may be captured by sensor units co-located with the autonomous vehicle. The method may include generating a mapping dataset including the obtained sensor data and identifying data elements that each represents a point in the mapping dataset. The method may include sorting the data elements according to a structural data categorization that is a template for a high-definition map of the total measurable world and determining a mapping trajectory of the autonomous vehicle. The mapping trajectory may describe a localization and a path of motion of the autonomous vehicle. The method may include generating the high-definition map based on the structural data categorization and relative to the mapping trajectory of the autonomous vehicle, and the high-definition map may be updated based on the path of motion of the autonomous vehicle.

Piperidine derivatives as orexin receptor antagonist.

La presente invención describe una serie de derivados de piperidina como antagonistas del receptor de orexina y composiciones de los mismos y se refiere a la aplicación de los mismos en la preparación de medicamentos para el tratamiento del insomnio, enfermedad pulmonar obstructiva crónica, apnea obstructiva del sueño, hipersomnia, ansiedad, trastorno obsesivo-compulsivo, ataque de pánico, adicción a la nicotina o trastorno de atracones de comida.

System and methods of adaptive traffic rule-based decision making for autonomous driving

A method may include obtaining input information relating to an environment in which an autonomous vehicle (AV) operates. The input information may describe a state of the AV, an operation of the AV within the environment, a property of the environment, or an object included in the environment. The method may include setting up a traffic rule profile for the AV that specifies societal traffic practices corresponding to a location of the environment. The method may include identifying a first traffic rule relevant to the AV based on the obtained input information and determining a first decision corresponding to the traffic rule profile and the first traffic rule. The method may include sending an instruction to a control system of the AV, the instruction describing a given operation of the AV responsive to the traffic rule profile and the first traffic rule according to the first decision.

System and methods of adaptive trajectory prediction for autonomous driving

A method may include obtaining one or more inputs in which each of the inputs describes at least one of: a state of an autonomous vehicle (AV) or a state of an object; and identifying a prediction context of the AV based on the inputs. The method may also include determining a relevancy of each object of a plurality of objects to the AV in relation to the prediction context; and outputting a set of relevant objects based on the relevancy determination for each of the plurality of objects. Another method may include obtaining a set of objects designated as relevant to operation of an AV; selecting a trajectory prediction approach for a given object based on context of the AV and characteristics of the given object; predicting a trajectory of the given object using the selected trajectory prediction approach; and outputting the given object and the predicted trajectory.

Obstacle detection systems

Virtual bumpers for autonomous vehicles improve effectiveness and safety as such vehicles are operated. One or more sensor systems having a Lidar sensor and a camera sensor determine proximity of objects around the vehicle and facilitate identification of the environment around the vehicle. The sensor systems are placed at various locations around the vehicle. The vehicle identifies an object and one or more properties of the identified object using the sensor systems. Based on the identified object and the properties of the object, a virtual bumper may be created for that object. For example, if the object is identified as another vehicle moving with a certain velocity, the vehicle may determine a minimum space to avoid the other vehicle, either by changing direction or reducing the velocity of the vehicle, with the minimum space constituting a virtual bumper.

サーモン産地の混合鑑別方法およびシステム

【課題】サーモン産地の混合鑑別方法およびシステムの提供。【解決手段】各国からの輸入サーモンのサンプルを採集すること、標準サーモンのサンプルの近赤外スペクトルを採集すること、δ１３Ｃ、δ１８Ｏ、δ１５Ｎ、Ｃａ、Ｃｌ、Ｍｇ、Ｐ、Ｋ、Ｎａ、Ｃｕ、Ｆｅ、Ｓｅ、Ａｓｐ、Ｔｈｒ、Ｓｅｒ、Ｇｌｕ、Ｇｌｙ、Ａｌａ、Ｃｙｓ、Ｖａｌ、Ｍｅｔ、Ｉｌｅ、Ｌｅｕ、Ｔｙｒ、Ｐｈｅ、Ｌｙｓ、Ｈｉｓ、Ａｒｇ、Ｐｒｏ、Ｔｒｐの値を採集すること、および、訓練して赤外スペクトルデータによる分類器、同位体質量分析データによる分類器、鉱物元素データによる分類器、アミノ酸データによる分類器を生成して、各分類器に対し順位づけを行い、４個の分類器の結果および順位づけ位置を総合して輸入サーモンの産地を判断することを含む。【選択図】図２

Polinucleótidos que codifican anticuerpos de roedores con idiotipos humanos y animales que los contienen

La invención se refiere a polinucleótidos, particularmente polinucleótidos quiméricos útiles para la producción óptima de inmunoglobulinas funcionales con idiotipos humanos en roedores. La invención se refiere además a roedores que comprenden tales polinucleótidos. (Traducción automática con Google Translate, sin valor legal)

System and method of adaptive distribution of autonomous driving computations

A method may include obtaining sensor data relating to an autonomous vehicle (AV) and a total measurable world around the AV. The method may include identifying an operating environment of the AV and determining a projected computational load for computing subsystems that facilitate a driving operation performable by the AV corresponding to the identified environment. The method may include off-loading first computing subsystems of the computing subsystems in which computations of the first computing subsystems may be processed by an off-board cloud computing system and processing computations associated with second computing subsystems of the computing subsystems by an on-board computing system. The method may include obtaining first computational results corresponding to the computations processed relating to the first computing subsystems and determining the driving operation of the AV based on the first computational results and second computational results corresponding to computations processed relating to the second computing subsystems.

Polinukleotidi, ki kodirajo protitelesa glodavcev s človeškimi idiotipi in živali, ki jih vsebujejo

Polinukleotydy kodujące przeciwciała gryzoni z ludzkimi idiotypami i zwierzęta je zawierające

Polinukleotidi koji kodiraju protutijela glodavaca s ljudskim idiotipovima i životinje koje ih sadrže

Internally emulisified polyurethane dispersion and method for preparing the same

An internally emulsified polyurethane dispersion, which is prepared by using a combined chain extender system of a hydrophilic amino siloxane compound and a polyetheramine compound, is provided. The internally emulsified polyurethane dispersion can be used to prepare a synthetic leather product having good anti-stickiness, wrinkle resistance, color fastness and superior mechanical properties. A laminated synthetic leather article prepared with said internally emulsified polyurethane dispersion as well a method for preparing the synthetic leather article are also provided.

Waterborne polyurethane dispersion and method for preparing the same

Methods and reagent for analysing nucleic acids from individual cells

The present disclosure relates to a bispecific reagent and a detection agent which are useful for the identification of an antibody-producing cell which produces an antibody that binds specifically to a target antigen. Further, the present disclosure relates to an assay for the identification of an antibody-producing cell which produces an antibody that binds specifically to a target antigen. The present disclosure also relates to kits comprising the bispecific reagent and the detection agent.

Systems and methods for software telemetry pipeline agent

A non-transitory computer readable medium stores instructions that, when executed by a processor, cause the processor to receive, from one or more processing nodes, data representative of usage and inventory of one or more software assets by one or more industrial automation devices of an industrial automation system that are communicatively coupled to the one or more processing nodes, determining a data delta for the industrial automation system that represents differences between the software asset data and a previous iteration of the software asset data, encrypt the data delta for the industrial automation system, and transmit the encrypted data delta for the industrial automation system to a remote server.

複数の重鎖免疫グロブリン遺伝子座を有するトランスジェニックげっ歯類由来のヒト抗体

【課題】本発明は、ヒトイディオタイプを有する機能性免疫グロブリンの最適な産生に有用なトランスジェニック動物に関する。【解決手段】本発明は、異なる染色体部位に組み込まれた二重／重複ヒト免疫グロブリンＶＤＪまたはＶＪ遺伝子セグメントを含む複数の人工Ｉｇ重鎖遺伝子座を含む、かつ内在性免疫グロブリンを産生する能力が欠如したトランスジェニック動物を提供する。【選択図】図１Ａ

Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same

The invention relates to polynucleotides, particularly chimeric polynucleotides useful for optimal production of functional immunoglobulins with human idiotypes in rodents. The invention further relates to rodents comprising such polynucleotides.

Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same

The invention relates to polynucleotides, particularly chimeric polynucleotides useful for optimal production of functional immunoglobulins with human idiotypes in rodents. The invention further relates to rodents comprising such polynucleotides.

Polinukleotidai, koduojantys graužikų antikūnus, turinčius žmogaus idiotipus, ir gyvūnai, apimantys juos

Polynukleotidit, jotka koodaavat jyrsijän vasta-aineita, joissa on ihmisen idiotyyppejä, ja näitä käsittävät eläimet

Polynukleotider, der koder for gnaverantistoffer med humane idiotyper, og dyr, der omfatter disse

Πολυνουκλεοτιδια τα οποια κωδικοποιουν αντισωματα τρωκτικων με ανθρωπινους ιδιοτυπους και ζωα τα οποια διαθετουν αυτα

Η εφεύρεση σχετίζεται με πολυνουκλεοτίδια, ειδικότερα με χιμαιρικά πολυνουκλεοτίδια χρήσιμα για τη βέλτιστη παραγωγή λειτουργικών ανοσοσφαιρινών με ανθρώπινους ιδιότυπους σε τρωκτικά. Η εφεύρεση σχετίζεται περαιτέρω με τρωκτικά που διαθέτουν τέτοια πολυνουκλεοτίδια.

Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same

System and method of large-scale autonomous driving validation

An autonomous driving validation system may include a primary advanced autonomy system located on board an autonomous vehicle (AV) that includes sensors, computing subsystems, and a drive-by-wire system. The primary advanced autonomy system may be configured to process first computations relating to a driving operation of the AV. The autonomous driving validation system may also include an off-board autonomous cloud computing system that includes cloud computing subsystems. The off-board autonomous cloud computing system may be configured to process second computations that are similar to the first computations processed by the primary advanced autonomy system. The autonomous driving validation system may include processors and non-transitory computer-readable storage media configured to store instructions that, in response to being executed, cause a system to perform operations relating to whether a likelihood of a problem arising during driving operation of the AV is above a threshold and generating a notification message regarding the problem.

System and methods of adaptive traffic rule-based decision making for autonomous driving

A method may include obtaining input information relating to an environment in which an autonomous vehicle (AV) operates. The input information may describe a state of the AV, an operation of the AV within the environment, a property of the environment, or an object included in the environment. The method may include setting up a traffic rule profile for the AV that specifies societal traffic practices corresponding to a location of the environment. The method may include identifying a first traffic rule relevant to the AV based on the obtained input information and determining a first decision corresponding to the traffic rule profile and the first traffic rule. The method may include sending an instruction to a control system of the AV, the instruction describing a given operation of the AV responsive to the traffic rule profile and the first traffic rule according to the first decision.

視野角切替可能な撮像装置及び無人船

【課題】視野角切替可能な撮像装置及び無人船を提供する。【解決手段】視野角切替可能な撮像装置は、第一角度範囲内で回転可能な撮像装置１と、撮像装置１と回転接続され、撮像装置１を第二角度範囲内で回転させる回転アーム２と、回転アーム２と回転接続され、回転アーム２を第二角度範囲内で回転するように駆動する駆動機構と、を含む。視野角切替可能な撮像装置は、２つの自由度内で回転可能で、１つは、撮像装置自身の回転軸を介して０〜１１５度範囲内で回転することであり、もう１つは、回転アームを介する回転であり、回転アームが初期位置から下へ０〜１００度回転可能であるため、視野角切替可能な撮像装置自身の回転と合わせると、基本的に、無人船体の下方におけるいかなる位置のターゲットも撮影することができる。【選択図】図１

Modular extensible behavioral decision system for autonomous driving

A method may include obtaining input information relating to an environment in which an autonomous vehicle (AV) operates in which the input information describes at least one of: a state of the AV, an operation of the AV within the environment, a property of the environment, or an object included in the environment. The method may include identifying a region of interest that represents a section of the environment based on the input information and identifying a portion of the environment based on the identified region of interest. The portion of the environment may include an object that affects operation of the AV. The method may include determining a first decision that relates to the object and sending an instruction to a control system of the AV describing a given operation of the AV responsive to the object according to the first decision.

System and method of large-scale automatic grading in autonomous driving using a domain-specific language

A method may include obtaining input information that describes a driving operation of a vehicle and obtaining a rule that indicates an approved driving operation of the vehicle. The method may include parsing the rule using a domain-specific language to generate rule conditions in which the domain-specific language is a programming language that is specifically designed for analyzing driving operations of vehicles. The method may include representing the input information as observations relating to the vehicle in which each of the observations is comparable to one or more of the rules. The method may include comparing the observations to one or more respective comparable rule conditions and generating a grading summary that evaluates how well the observations satisfy the respective comparable rule conditions based on the comparison. A future driving operation of the vehicle may be adjusted based on the grading summary.

キメラ抗原受容体

【課題】低密度標的抗原に結合し、Ｆａｂ抗原結合ドメインを含むキメラ抗原受容体（ＣＡＲ）を提供すること。【解決手段】また、本発明は、かかるＣＡＲを発現する細胞および疾患の処置におけるその使用に関する。本発明者らは、低密度標的抗原を標的にするＣＡＲ－Ｔ細胞について、Ｆａｂ抗原結合ドメインを有するＣＡＲを使用するとＣＡＲ媒介シグナル伝達がより効率的になることを見出した。本発明の第１の態様の別の実施形態では、Ｆａｂ抗原結合ドメインは、第１の標的抗原に結合する第１の結合ドメインおよび第２の標的抗原に結合する第２の結合ドメインを含み得る。【選択図】なし

Ｔｒｂｃ使用の分子的評価

【課題】細胞のＴ細胞受容体β鎖（ＴＲＢＣ）遺伝子のタイプを決定する方法を提供すること。【解決手段】本発明は、細胞のＴ細胞受容体β鎖（ＴＲＢＣ）遺伝子のタイプを決定する方法であって、（ａ）前記細胞で発現されたＪ遺伝子のタイプを決定するステップ、および（ｂ）（ａ）から、前記細胞で発現されたＴＲＢＣ遺伝子のタイプを推測するステップを含む、方法に関する。本発明はさらに、Ｔ細胞受容体β鎖（ＴＲＢＣ）のタイプ１に標的化されたＣＡＲ Ｔ細胞、またはＴ細胞受容体β鎖（ＴＲＢＣ）のタイプ２に標的化されたＣＡＲ Ｔ細胞の使用に関する。本発明はさらに、薬物処置の方法、および核酸プローブに関する。【選択図】なし

プログラムおよび支援方法

【課題】標的生体分子の活性を制御する化合物の候補をより正確に予測することができるプログラムを提供することを目的とする。 【解決手段】受容体の立体構造を示す立体構造ファイルおよび複数のリガンドの立体構造を示す情報を有する低分子化合物データベースを用いて、受容体と複数のリガンドとの結合エネルギーや結合モデルを算出する第１シミュレーション（ＤＳ）を計算機に実行させる第１処理ステップ（Ｓ１）と、前記複数のリガンドのうち選択された一のリガンドが受容体にドッキングされたリガンド複合体の一の立体配置を計算する第２シミュレーション（ＭＤ）を計算機に実行させる第２処理ステップ（Ｓ２）と、当該一の立体配置の量子化学計算を行う第３シミュレーション（ＱＣ）を計算機に実行させ、受容体と選択された一のリガンドと相互作用エネルギーとの情報をもつ算出結果を得る第３処理ステップ（Ｓ３）とを、含む。 【選択図】図２

System and method of computation acceleration for autonomous driving systems

A method may include identifying computing systems corresponding to an autonomous vehicle (AV) in which each computing system is configured to perform at least one operation relating to driving the AV. The method may include determining whether the computing systems use a first respective real-world parameter as an input to any of the operations or generate a second respective real-world parameter as an output of the operations. A respective operation corresponding to a respective computing system may be designated for accelerated performance based on the determination, and the operations of the computing systems may be performed. A first operation not designated for accelerated performance may include first computations corresponding to the first operation after waiting for a synchronization delay period, and a second operation designated for accelerated performance may include second computations corresponding to the second operation and performed without waiting for the synchronization delay period.

Three-dimensional object detection with ground removal intelligence

A method may include obtaining sensor data from one or more LiDAR units and determining a point-cloud corresponding to the sensor data obtained from each respective LiDAR unit. The method may include aggregating the point-clouds as an aggregated point-cloud and generating an initial proposal for a two-dimensional ground model made of multiple grid blocks. The method may include filtering out unrelated raw data points from each grid block of the plurality of grid blocks to generate a filtered point-cloud matrix. The method may include identifying one or more surface-points and one or more object-points included in the filtered point-cloud matrix and generating an array of extracted objects based on the object-points.

System and method of large-scale automatic grading in autonomous driving using a domain-specific language

A method may include obtaining input information that describes a driving operation of a vehicle and obtaining a rule that indicates an approved driving operation of the vehicle. The method may include parsing the rule using a domain-specific language to generate rule conditions in which the domain-specific language is a programming language that is specifically designed for analyzing driving operations of vehicles. The method may include representing the input information as observations relating to the vehicle in which each of the observations is comparable to one or more of the rules. The method may include comparing the observations to one or more respective comparable rule conditions and generating a grading summary that evaluates how well the observations satisfy the respective comparable rule conditions based on the comparison. A future driving operation of the vehicle may be adjusted based on the grading summary.

Device control method and apparatus, storage medium, and electronic device

Self-adaptive lidar-camera synchronization system

A method may include determining an alignment time based on a zero-crossing point corresponding to a LiDAR sensor and a horizontal field of view corresponding to an image- capturing sensor. The method may include determining a delay timing for initiating image capturing by the image-capturing sensor in which the delay timing is based on at least one of: the alignment time, a packet capture timing corresponding to the LiDAR sensor, and an average frame exposure duration corresponding to the image-capturing sensor. The method may include initiating data capture by the LiDAR sensor, and after the initiating of data capture by the LiDAR sensor and after the delay timing has elapsed., initiating data capture by the image- capturing sensor.

System and method of same-loop adaptive simulation for autonomous driving

A method may include obtaining, by an autonomous driving system, input information relating to an autonomous vehicle (AV). The method may include determining, by the autonomous driving system, one or more driving signals that describe operations of the AV. The method may include instructing the AV to move according to the driving signals and simulating, by a virtual driving system, movement of the AV based on the driving signals, wherein the simulating the movement of the AV occurs concurrently with the AV moving according to the driving signals as instructed.

Self-adaptive lidar-camera synchronization system

A method may include determining an alignment time based on a zero-crossing point corresponding to a LiDAR sensor and a horizontal field of view corresponding to an image-capturing sensor. The method may include determining a delay timing for initiating image capturing by the image-capturing sensor in which the delay timing is based on at least one of: the alignment time, a packet capture timing corresponding to the LiDAR sensor, and an average frame exposure duration corresponding to the image-capturing sensor. The method may include initiating data capture by the LiDAR sensor, and after the initiating of data capture by the LiDAR sensor and after the delay timing has elapsed, initiating data capture by the image-capturing sensor.

Method for treating cancer patients using c-met inhibitor

Internally emulsified polyurethane dispersion and method for preparing the same

An internally emulsified polyurethane dispersion, which is prepared by using a combined chain extender system of a hydrophilic amino siloxane compound and a polyetheramine compound, is provided. The internally emulsified polyurethane dispersion can be used to prepare a synthetic leather product having good anti-stickiness, wrinkle resistance, color fastness and superior mechanical properties. A laminated synthetic leather article prepared with said internally emulsified polyurethane dispersion as well a method for preparing the synthetic leather article are also provided.

Waterborne polyurethane dispersion and method for preparing the same

A waterborne polyurethane dispersion is provided. The waterborne polyurethane dispersion is prepared by using a tri-functionality polyether polyol as part of the polyols for forming the prepolymer and a hydrophilic amino siloxane co-chain extender, and can exhibit superior performance properties such as enhanced color fastness, improved low temperature stability, good anti-stickiness, bally flex resistance, anti-abrasion and mechanical properties. A laminated synthetic leather article prepared with said waterborne polyurethane dispersion as well the method for preparing the synthetic leather article are also provided.

Systems and methods for software telemetry pipeline agent

A non-transitory computer readable medium stores instructions that, when executed by a processor, cause the processor to receive, from one or more processing nodes, data representative of usage and inventory of one or more software assets by one or more industrial automation devices of an industrial automation system that are communicatively coupled to the one or more processing nodes, determining a data delta for the industrial automation system that represents differences between the software asset data and a previous iteration of the software asset data, encrypt the data delta for the industrial automation system, and transmit the encrypted data delta for the industrial automation system to a remote server.

Methods and reagent for analysing nucleic acids from individual cells

The present disclosure relates to a bispecific reagent and a detection agent which are useful for the identification of an antibody-producing cell which produces an antibody that binds specifically to a target antigen. Further, the present disclosure relates to an assay for the identification of an antibody-producing cell which produces an antibody that binds specifically to a target antigen. The present disclosure also relates to kits comprising the bispecific reagent and the detection agent.

Horizontal biogas manure distributor

The present invention relates to a horizontal biogas manure distributor, and belongs to the field of agricultural machinery technologies. The distributor includes a barrel-shaped shell, a rotor, and a cutting knife assembly, where an internal bottom surface of the shell is fixedly connected to a first cutting screen, and an inner surface of the shell cover is fixedly connected to a second cutting screen; the rotor is disposed inside the shell, and a first connector and a second connector are respectively disposed on two ends of the rotor; the cutting knife assembly includes a first cutting knife and a second cutting knife, the first cutting knife adjoins the first cutting screen, and the second cutting knife adjoins the second cutting screen; and an eccentric adjustment mechanism is disposed between the first connector and the second connector, and the eccentric adjustment mechanism includes a first cam and a second cam that are arranged in a row and that abut against each other. The distributor can ensure even distribution of biogas manure, no clogging, and high distribution efficiency without separating biogas slurry in advance.

Chimeric antigen receptor

The present invention provides a chimeric antigen receptor (CAR) which binds a target antigen having a bulky extracellular domain, wherein the CAR comprises a Fab antigen binding domain. The present invention also provides nucleic acid sequences and constructs encoding such a CAR, cells expressing such a CAR and their therapeutic uses.

Human antibodies from transgenic rodents with multiple heavy chain immunoglobulin loci

The invention relates to transgenic animals useful for optimal production of functional immunoglobulins with human idiotypes.

Adaptive motion compensation of perception channels

A method may include obtaining sensor data describing a total measurable world around a motion sensor. The method may include processing the sensor data to generate a pre-compensation scan of the total measurable world around the motion sensor based on the sensor data. The method may include determining a delay between the obtaining the sensor data and the generation of the pre-compensation scan. The method may include obtaining motion data corresponding to motion of the motion sensor and generating a motion model of the motion sensor based on the motion data. The method may include generating an after-compensation scan of the motion sensor using the delay and the motion model to compensate for continued motion during the delay.

Ihmisen idiotyyppejä omaavia jyrsijän vasta-aineita koodittavia polynukleotideja ja niitä käsittäviä eläimiä

Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same

The invention relates to polynucleotides, particularly chimeric polynucleotides useful for optimal production of functional immunoglobulins with human idiotypes in rodents. The invention further relates to rodents comprising such polynucleotides.

Polynukleotider, der koder for graver-antistoffer med humane idiotyper, og dyr, der omfatter disse

Polinukleotydy kodujące przeciwciała gryzoni z ludzkimi idiotypami i zawierające je zwierzęta

Human antibodies from transgenic rodents with multiple heavy chain immunoglobulin loci

The invention relates to transgenic animals useful for optimal production of functional immunoglobulins with human idiotypes.

Waterborne polyurethane dispersion and method for preparing the same

A waterborne polyurethane dispersion is provided. The waterborne polyurethane dispersion is prepared by using a tri-functionality polyether polyol as part of the polyols for forming the prepolymer and a hydrophilic amino siloxane co-chain extender, and can exhibit superior performance properties such as enhanced color fastness, improved low temperature stability, good anti-stickiness, bally flex resistance, anti-abrasion and mechanical properties. A laminated synthetic leather article prepared with said waterborne polyurethane dispersion as well the method for preparing the synthetic leather article are also provided.

System and methods of adaptive trajectory prediction for autonomous driving

A method may include obtaining one or more inputs in which each of the inputs describes at least one of: a state of an autonomous vehicle (AV) or a state of an object; and identifying a prediction context of the AV based on the inputs. The method may also include determining a relevancy of each object of a plurality of objects to the AV in relation to the prediction context; and outputting a set of relevant objects based on the relevancy determination for each of the plurality of objects. Another method may include obtaining a set of objects designated as relevant to operation of an AV; selecting a trajectory prediction approach for a given object based on context of the AV and characteristics of the given object; predicting a trajectory of the given object using the selected trajectory prediction approach; and outputting the given object and the predicted trajectory.

Adaptive motion compensation of perception channels

A method may include obtaining sensor data describing a total measurable world around a motion sensor. The method may include processing the sensor data to generate a pre- compensation scan of the total measurable world around the motion sensor based on the sensor data. The method may include determining a delay between the obtaining the sensor data and the generation of the pre-compensation scan. The method may include obtaining motion data corresponding to motion of the motion sensor and generating a motion model of the motion sensor based on the motion data. The method may include generating an after-compensation scan of the motion sensor using the delay and the motion model to compensate for continued motion during the delay.

System and methods of adaptive object-based decision making for autonomous driving

A method may include obtaining input information relating to an environment in which an autonomous vehicle (AV) operates, the input information describing at least one of: a state of the AV, an operation of the AV within the environment, a property of the environment, or an object included in the environment. The method may include identifying a first object in the vicinity of the AV based on the obtained input information. The method may include determining a first object rule corresponding to the first object, the first object rule indicating suggested driving behavior for interacting with the first object. The method may include determining a first decision that follows the first object rule and sending an instruction to a control system of the AV, the instruction describing a given operation of the AV responsive to the first object rule according to the first decision.