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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 3. Отображено 3.
29-09-2010 дата публикации

Recombinant adenovirus and application thereof

Номер: CN0101845419A
Автор: JUHAO CHEN, AI CHEN RUI, HONGLIANG HUANG, GENMEI LIU, MANLIN LUO, CHEN JUHAO, CHEN RUI'AI, HUANG HONGLIANG, LIU GENMEI, LUO MANLIN
Принадлежит:

The invention discloses a recombinant adenovirus, which is obtained by fusing and connecting an open reading frame 2 (ORF2) of an immunogenicity protein gene of porcine circovirus type 2 (PCV2) and a signal peptide-removed porcine interferon-gamma (IFN-gamma) gene and then recombining the fused and connected genes to an adenovirus vector. The ORF2 of the main immunogenicity protein of the PCV2 and the signal peptide-removed porcine IFN-gamma are fused with each other and then are expressed in the adenovirus, so that the immunogenicity of the ORF2 is improved and the immunity effect is enhanced compared with the single ORF2. The obtained recombined adenovirus, serving as vaccine, can be applied to epidemic prevention of the porcine circovirus.

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Номер записи: 1
01-09-2010 дата публикации

Gene segments for coding alpha, beta or gamma interferons of pigs and application thereof

Номер: CN0101818154A
Автор: RUIAI CHEN, JIAN LIU, MANLIN LUO, MINGSEN TANG, XIN ZHANG, CHEN RUIAI, LIU JIAN, LUO MANLIN, TANG MINGSEN, ZHANG XIN
Принадлежит:

The invention relates to gene segments for coding alpha, beta or gamma interferons of pigs and an application thereof. According to the preference of codons of a Pichia stipitis expression system, high-expression codons are selected to renewedly design and synthesize new mature peptide nucleotide sequences of the alpha, beta and gamma interferon of the pigs, and recombinant yeast expression plasmids of pPICZalphaC-IFN-alpha, pPICZalphaC-IFN-beta and pPICZaplhaC-IFN-gamma are successfully constructed, which not only correctly expresses the alpha, beta and gamma interferons of the pigs in Pichia stipitis, but also enables the alpha, beta and gamma interferons of the pigs to be easier to express in the Pichia stipitis with higher expression level, and lays a foundation for the large-scale production and fermentation of the gene engineering.

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Номер записи: 2
17-08-2011 дата публикации

Recombinant adenovirus and application thereof

Номер: CN0101845419B
Автор: CHEN JUHAO, CHEN RUI'AI, HUANG HONGLIANG, LIU GENMEI, LUO MANLIN, JUHAO CHEN, AI CHEN RUI, HONGLIANG HUANG, GENMEI LIU, MANLIN LUO
Принадлежит:

The invention discloses a recombinant adenovirus, which is obtained by fusing and connecting an open reading frame 2 (ORF2) of an immunogenicity protein gene of porcine circovirus type 2 (PCV2) and a signal peptide-removed porcine interferon-gamma (IFN-gamma) gene and then recombining the fused and connected genes to an adenovirus vector. The ORF2 of the main immunogenicity protein of the PCV2 and the signal peptide-removed porcine IFN-gamma are fused with each other and then are expressed in the adenovirus, so that the immunogenicity of the ORF2 is improved and the immunity effect is enhanced compared with the single ORF2. The obtained recombined adenovirus, serving as vaccine, can be applied to epidemic prevention of the porcine circovirus.

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Номер записи: 3