MEDICAL TREATMENTS BASED ON ANAMORELIN

MEDICAL TREATMENTS BASED ON ANAMORELIN

Methods of treating cancer related conditions using anamorelin are described. 1) A method of treating cachexia in a human cancer patient having a body weight loss greater than or equal to 2% in the previous 6 months and a body mass index less than 20 kg/m , comprising administering to the patient a therapeutically effective amount of anamorelin or pharmaceutically acceptable salt thereof once daily for a therapeutically effective period of time.2) The method of claim 1 , further comprising increasing the total body mass of the patient.3) The method of claim 1 , further comprising increasing the total body mass claim 1 , lean body mass claim 1 , and fat mass of the patient.4) The method of claim 1 , further comprising improving the quality of life of the patient as measured by FAACT in the anorexia/cachexia domain.5) The method of claim 1 , wherein the therapeutically effective amount of anamorelin or pharmaceutically acceptable salt thereof comprises 100 mg of anamorelin hydrochloride based on the weight of the salt.6) A method of treating cachexia in a human cancer patient having a body weight loss greater than or equal to 2% in the previous 6 months and a body mass index less than 20 kg/m claim 1 , comprising administering to the patient a therapeutically effective amount of anamorelin or pharmaceutically acceptable salt thereof once daily for a therapeutically effective period of time and increasing total body mass of the patient.7) The method of claim 6 , comprising increasing the total body mass of the patient by 5% or more.8) The method of claim 6 , further comprising improving the quality of life of the patient as measured by FAACT in the anorexia/cachexia domain.9) The method of claim 6 , wherein the therapeutically effective amount of anamorelin or pharmaceutically acceptable salt thereof comprises 100 mg of anamorelin hydrochloride based on the weight of the salt.10) A method of treating cachexia in a human cancer patient having a body weight loss greater ...

PYROGLUTAMINSÄUREDERIVATE UND DAMIT VERWANDTE VERBINDUNGEN, DIE DIE DURCH VLA-4 VERMITTELTE LEUKOZYTENADHÄSION VERRINGERN

MEDICAL TREATMENTS BASED ON ANAMORELIN

Methods of treating cancer related conditions using anamorelin are described. The principal embodiment relates to the unique condition of patients defining this condition by treating cachexia in a human cancer patient, comprising administering to said patient a therapeutically effective amount of anamorelin for a therapeutically effective period of time, and observed surprising ability of anamorelin to increase lean body mass in this population.

MAIL BAG CATCHER

Medical treatments based on anamorelin

Methods of treating cancer related conditions using anamorelin are described. The principal embodiment relates to the unique condition of patients defining this condition by treating cachexia in a human cancer patient, comprising administering to said patient a therapeutically effective amount of anamorelin for a therapeutically effective period of time, and observed surprising ability of anamorelin to increase lean body mass in this population.

Combined Cover and Marker for Magazines, Pamphlets and the like.

... 19,011. Mann, W. Sept. 3. Bookmarkers; bookbinding.-A flap C is attached to, or formed with, a limp cover A, B, for a magazine, pamphlet, or the like, so that its free end may be inserted between the leaves of the magazine to act as a marker.

AUTOMOTIVE IGNITION SYSTEMS

EXPLOSIVE CONNECTING CORD

SAFETY FUSE BLASTING ASSEMBLY

CALF WEANER

SHORT INTERVAL DELAY BLASTING DEVICE

Tag dispenser

A tag dispenser 1 comprises means for holding a web of a plurality of interconnected tags (fig 6), a housing defining a dispensing pathway 20 along which a leading tag of a web of a plurality of interconnected tags held by the holding means may be supplied to a dispenser opening to enable the leading tag to be gripped by a user, a projection 4 projecting into said dispensing pathway for locating and engaging an aperture (33, fig 6) of a leading tag to prevent it being pulled out of said dispenser opening and a tag release means 3 moveable so as to disengage a leading tag from said projection.

Improvements in Machines for Casting Metals.

... 17,724. Mann, W. Aug. 1. Piston valves. - A valve for controlling air-supply in a pressure casting machine has a tubular stem 4 slidable within a casing 1 supplied with air at 2 and held seated on a washer 6 by a spring 8. Small holes 7, arranged as shown, provide for a more or less rapid passage of air as required. A rubber ring 11 prevents leakage.

Improvements in or relating to Air-compressing Devices.

BRAKE SHOE LINING FOR DE-ICING BRAKE SURFACES

Medical treatments based on anamorelin

Methods of treating cancer related conditions using anamorelin are described. The principal embodiment relates to the unique condition of patients defining this condition by treating cachexia in a human cancer patient, comprising administering to said patient a therapeutically effective amount of anamorelin for a therapeutically effective period of time, and observed surprising ability of anamorelin to increase lean body mass in this population.

MEDICAL TREATMENTS BASED ON ANAMORELIN

Methods of treating cancer related conditions using anamorelin are described. The principal embodiment relates to the unique condition of patients defining this condition by treating cachexia in a human cancer patient, comprising administering to said patient a therapeutically effective amount of anarnorelin for a therapeutically effective period of time, and observed surprising ability of anamorelin to increase lean body mass in this population.

MEDICAL TREATMENTS BASED ON ANAMORELIN

Methods of treating cancer related conditions using anamorelin are described. 123-. (canceled)24. A method of treating cancer associated weight loss in a patient in need thereof comprising administering to said patient a therapeutically effective amount of anamorelin or a pharmaceutically acceptable salt thereof , wherein:{'sup': '2', 'a. said patient has a body mass index of <20 kg/m; and'}b. said patient has involuntary weight loss of >2% during the previous 6 months.251. The method of claim , wherein said patient has an ECOG score of 0 , 1 , or 2.261. The method of claim , further for treating anorexia symptoms in said patient , wherein said patient has low quality of life as measured by FAACT in the anorexia/cachexia domain.271. The method of claim , further for treating anorexia symptoms in said patient , wherein:a. said patient has low quality of life as measured by FAACT in the anorexia/cachexia domain; andb. said patient has low physical and functional well-being as measured by FAACT in the anorexia/cachexia domain.28. The method of claim 24 , wherein said patient has stage III unresectable or stage IV NSCLC.29. The method of claim 24 , wherein said therapeutically effective amount comprises 100 mg of anamorelin or a pharmaceutically acceptable salt thereof once daily.30. The method of claim 24 , wherein said therapeutically effective amount comprises 100 mg of anamorelin HCl based on the weight of the salt administered once daily.31. The method of claim 26 , wherein said method increases the body weight of said patient and improves anorexia symptoms as measured by FAACT in the anorexia/cachexia domain.32. The method of claim 27 , wherein said method increases the body weight of said patient and improves physical and functional well-being as measured by FAACT in the anorexia/cachexia domain.33. The method of claim 27 , wherein said method increases the body weight of said patient claim 27 , improves physical and functional well-being as measured by FAACT in ...

PYROGLUTAMINSÄUREDERIVATE UND DAMIT VERWANDTE VERBINDUNGEN, DIE DIE DURCH VLA-4 VERMITTELTE LEUKOZYTENADHÄSION VERRINGERN

Medical treatments based on anamorelin

Methods of treating cancer related conditions using anamorelin are described.

Tratamientos médicos a base de anamorelina.

...

SE DESCRIBEN MÉTODOS DE TRATAMIENTO DE AFECCIONES RELACIONADAS CON EL CÁNCER USANDO ANAMORELINA. LA MODALIDAD PRINCIPAL SE RELACIONA CON LA AFECCIÓN ÚNICA DE PACIENTES QUE LA DEFINEN MEDIANTE EL TRATAMIENTO DE LA CAQUEXIA EN UN PACIENTE HUMANO CON CÁNCER, QUE COMPRENDE LA ADMINISTRACIÓN A DICHO PACIENTE DE UNA CANTIDAD TERAPÉUTICAMENTE EFECTIVA DE ANAMORELINA DURANTE UN PERÍODO TERAPÉUTICAMENTE EFECTIVO, Y LA SORPRENDENTE CAPACIDAD OBSERVADA DE LA ANAMORELINA DE AUMENTAR LA MASA CORPORAL MAGRA DE ESTA POBLACIÓN.

Medical treatments based on anamorelin

Medical treatments based on anamorelin

Methods of treating cancer related conditions using anamorelin are described.

Medical treatments based on anamorelin

Methods of treating cancer related conditions using anamorelin are described.

MEDICAL TREATMENTS BASED ON ANAMORELIN

MEDICAL TREATMENTS BASED ON ANAMORELIN

Methods of treating cancer related conditions using anamorelin are described. 123-. (canceled)24. A method of treating weight loss in a human cancer patient comprising administering to said patient 100 mg of anamorelin or a pharmaceutically acceptable salt thereof once daily for a therapeutically effective period of time.25. A method of treating early satiety in a human cancer patient comprising administering to said patient 100 mg of anamorelin or a pharmaceutically acceptable salt thereof once daily for a therapeutically effective period of time.26. A method of improving quality of life as measured by FAACT in the anorexia/cachexia domain in a human cancer patient comprising administering to said patient 100 mg of anamorelin or a pharmaceutically acceptable salt thereof once daily for a therapeutically effective period of time.27. A method of increasing total body mass , lean body mass , and fat mass in a human cancer patient comprising administering to said patient 100 mg of anamorelin or a pharmaceutically acceptable salt thereof once daily for a therapeutically effective period of time.28. The method of claim 24 , wherein said patient has a BMI less than 20 kg/m.29. The method of claim 24 , wherein said patient has a BMI less than 20 kg/mand a body weight loss greater than 2% in the previous 6 months.30. The method of claim 24 , wherein said patient has a performance status on the ECOG scale of 2 or higher.31. The method of claim 24 , wherein said therapeutically effective amount of anamorelin comprises 100 mg of anamorelin HCl based on the weight of the salt administered orally once daily at least one hour before the first meal.32. The method of claim 24 , wherein said therapeutically effective period of time is twelve weeks.33. The method of claim 24 , wherein the method further treats early satiety.34. The method of claim 24 , wherein the method further improves quality of life as measured by FAACT in the anorexia/cachexia domain.35. The method of claim 24 , ...

MÃ ‰ DICOS TREATMENTS BASED ANAMORELINA

SE DESCRIBEN MÉTODOS DE TRATAMIENTO DE AFECCIONES RELACIONADAS CON EL C�NCER USANDO ANAMORELINA. LA MODALIDAD PRINCIPAL SE RELACIONA CON LA AFECCIÓN ÚNICA DE PACIENTES QUE LA DEFINEN MEDIANTE EL TRATAMIENTO DE LA CAQUEXIA EN UN PACIENTE HUMANO CON C�NCER, QUE COMPRENDE LA ADMINISTRACIÓN A DICHO PACIENTE DE UNA CANTIDAD TERAPÉUTICAMENTE EFECTIVA DE ANAMORELINA DURANTE UN PERIODO TERAPÉUTICAMENTE EFECTIVO, Y LA SORPRENDENTE CAPACIDAD OBSERVADA DE LA ANAMORELINA DE AUMENTAR LA MASA CORPORAL MAGRA DE ESTA POBLACIÓN ...

Medical treatments based on anamorelin

Methods of treating cancer related conditions using anamorelin are described.

Method of stimulating the motility of the gastrointestinal system using ipamorelin

The present invention provides a method of stimulating the motility of the gastrointestinal system in a subject in need thereof, wherein the subject suffers from maladies (i.e., disorders, diseases, conditions, or drug- or surgery-induced dysfunction) of the gastrointestinal system, by administering to the subject a ghrelin mimetic, or pharmaceutically acceptable salt thereof. The invention also provides a method of treating a gastrointestinal malady by co-administering a ghrelin mimetic with a laxative, a Hreceptor antagonist, a serotonin receptor agonist, pure or mixed, an antacid, an opioid antagonist, a proton pump inhibitor, a motilin receptor agonist, dopamine antagonist, a cholinergic agonist, a cholinesterase inhibitor, somatostatin, octreotide, or any combination thereof. 118-. (canceled)20. The method of claim 19 , wherein the subject is using an opioid for post-surgical pain management.21. The method of claim 19 , wherein the subject is using an opioid for chronic pain management.22. The method of claim 21 , wherein the opioid is selected from the group consisting of morphine claim 21 , codeine claim 21 , oxycodone claim 21 , hydromorphone claim 21 , hydrocodone claim 21 , methadone claim 21 , and fentanyl.23. The method of claim 19 , wherein the compound is administered in a manner in order to achieve an effective plasma concentration.25. The method of claim 24 , wherein the compound is administered in a manner to achieve an effective plasma concentration.26. The method of claim 19 , consisting essentially of administering said compound or a pharmaceutically acceptable salt thereof.27. The method of claim 24 , consisting essentially of administering said compound or a pharmaceutically acceptable salt thereof.28. The method of claim 19 , wherein said administration is via injection.29. The method of claim 24 , wherein said administration is via injection. This application is a continuation-in-part of U.S. application Ser. No. 11/203,639, filed Aug. 12, ...

ATTACHING A LINE TO A SURFACE

Among other things, a communication line is attached along a target surface of a building by laying out the line from a tool. An outer surface of the line is in a temporarily tacky condition as the line is laid out along the surface. The line is in the temporarily tacky condition based at least in part on an adhesive component having been pre-applied to the outer surface of the line. The line becomes non-tacky after it has been attached. 1. A method comprisingattaching a communication line along a target surface of a building by laying out the line from a tool, an outer surface of the line being in a temporarily tacky condition as the line is laid out along the surface, the line being in the temporarily tacky condition based at least in part on an adhesive component having been pre-applied to the outer surface of the line, the line becoming non-tacky after it has been attached.2. The method of in which the pre-applied adhesive component is activated at the tool.3. The method of which the pre-applied adhesive component is activated by a fluid in the tool.4. The method of in which the line becomes non-tacky within an hour after it has been attached.5. The method of in which the line becomes non-tacky within 30 minutes after it has been attached.6. The method of in which the line becoming non-tacky comprises the line becoming dry.7. The method of comprising imparting the temporarily tacky condition to the line immediately prior to the line being laid out from the tool.8. The method of comprising imparting the temporarily tacky condition to the line by applying a fluid material to an outer surface of the line.9. The method of in which a portion of the activated adhesive component flows onto the target surface from the line after the line has been laid out.10. The method of in which the line is pressed against the exposed surface by the tool as the line is being laid out.11. The method of in which the target surface is on at least one of a wall claim 1 , a floor claim 1 ...

REDUNDANT SOLID STATE DISK SYSTEM VIA INTERCONNECT CARDS

A first interconnect card is configured, wherein a first controller is included in the first interconnect card. A second interconnect card coupled to the first interconnect card is configured, wherein a second controller is included in the second interconnect card. In response to a failure of the first controller included in the first interconnect card, the first interconnect card is controlled via the second controller included in the second interconnect card. In response to a failure of the second controller included in the second interconnect card, the second interconnect card is controlled via the first controller included in the first interconnect card. 1. A method , comprising:configuring, by a processor, a first interconnect card, wherein a first controller is included in the first interconnect card, wherein the first interconnect card includes a capacitor to provide power and to maintain the first interconnect card in an operational state, in response to a failure of external power to the first interconnect card;configuring a second interconnect card coupled to the first interconnect card, wherein a second controller is included in the second interconnect card;in response to a failure of the first controller included in the first interconnect card, controlling the first interconnect card via the second controller included in the second interconnect card; andin response to a failure of the second controller included in the second interconnect card, controlling the second interconnect card via the first controller included in the first interconnect card.2. The method of claim 1 , wherein the first interconnect card also includes a battery in addition to the capacitor to provide power and to maintain the first interconnect card in an operational state claim 1 , in response to a failure of external power to the first interconnect card.3. The method of claim 1 , wherein the first controller is included in a daughter card claim 1 , the method further comprising: ...

Methods of treating emesis using growth hormone secretagogues

The present invention relates to methods of treating or preventing emesis and improving a subject's ASAS score by administering to the subject an effective amount of a growth hormone secretagogue compound or a pharmaceutically acceptable salt, hydrate or solvate thereof.

Data-Record Pattern Searching

A record-pattern expression of a record pattern of data records is translated to a character-pattern expression of a character pattern. A data-record series of data records is converted to a character string in which each character in the character string corresponds to a respective data record in the data-record series. Pattern instances of the character pattern in the character string are searched to identify ordinal character positions in the character string of characters in the character pattern instances. Data records at ordinal record positions in the record series of data records corresponding to the ordinal character positions are reported. 1. A computer-implemented process comprising:translating a record-pattern expression of a record pattern of data records to a regular expression of a character pattern;converting a record series of data records to a character string in which each character in the character string corresponds to a respective data record in the record series;searching for pattern instances of the character pattern in the character string to identify ordinal character positions in the character string of characters in the pattern instances; andreporting data records at ordinal record positions in the record series of data records corresponding to the ordinal character positions.2. A process as recited in wherein the converting includes:converting the record series into a record-type series by categorizing the data records into record types; andconverting the record-type series to the character string by mapping record-types to characters.3. A process as recited in wherein the searching implements an overlapping character-pattern matching procedure.4. A process as recited in wherein the searching implements a non-overlapping character-pattern matching procedure such that claim 3 , once a match is found claim 3 , searching continues for the next match starting from the character immediately following the last character of the last pattern ...

Waterfall Prioritized Payment Processing

The invention comprises a system and method for “waterfall” type payment processing using multiple alternative payment sources. A payor provides account information for multiple payment sources, such as a bank checking account, savings account, first credit card account, second credit card account, and so forth. The multiple payment sources are prioritized so that one is a primary payment source, another is a secondary payment source, another is a tertiary payment source, and so forth. After setting up the waterfall payment arrangement, when a bill becomes due a payee or third party payment administrator submits transactions against the payment sources in their order of priority until the payment is satisfied. Other variations and enhancements are disclosed. 134-. (canceled)35. A computer-implemented method of prioritized processing of payments from a payor to a payee , the method comprising:storing, in at least one non-transitory computer memory, executable instructions and a plurality of payment source options, the payment source options including multiple types of source accounts; facilitating creation of priority rules for prioritizing the payment source options for payment from the payor, wherein each of said types of source accounts is selectable as a primary payment source having a first priority and a secondary payment source having a second priority to be usable for future payments from the payor and storing the priority rules in the at least one non-transitory computer memory;', 'communicating with the payor over a network to establish charge distribution rules for distributing a payment across at least two of the prioritized plurality of payment source options according to the priority rules, wherein at least one of the charge distribution rules requires distributing the payment across multiple payment source options even when the primary payment source has sufficient funds to satisfy a payment due;', 'identifying a payment due from the payor;', ' ...

Purchase Data Transmission and Analysis System

A system may perform steps such as receiving a bank card transaction authorization stream including a URL originating from the merchant computing system, the URL received in a discretionary field in the authorization stream for a bank card purchase. The system further perform the step of retrieving information at a location referenced by the URL, wherein the information includes at least a merchant identifier and line item data related to a purchase. The system may additionally attaching the retrieved data to the transaction to create a complete description of the transaction analyze the complete description of the transaction for creating at least one customer interface for the customer and at least one merchant interface for the merchant based on the analysis. 124.-. (canceled)25. A system for facilitating purchase data capture and analysis , the system operating over a network and in conjunction with a user mobile device and a merchant computing system , the system comprising:at least one computer memory storing instructions; receiving transaction information from a merchant;', 'providing an image capture application for the mobile device for processing an image capture request from a user to capture a receipt, wherein processing the request includes providing a leveling function and a matching function, the leveling function ensuring that the receipt information is fully captured based on an angle between the user mobile device and the receipt and the matching function ensuring that each edge of a captured receipt portion matches an edge of another captured receipt portion;', 'matching the captured customer receipt with the transaction information from the merchant; and', 'analyzing the transaction for creating at least one customer interface for the customer and at least one merchant interface for the merchant based on the analysis., 'at least one computer processor accessing the at least one computer memory and executing the stored instructions for performing ...

Medical treatments based on anamorelin

Methods of treating cancer related conditions using anamorelin are described.

System and Method for Applying an Adhesive Coated Cable to a Surface

A system and method for installing a fiber or cable on a wall or ceiling of a structure includes providing a fiber, wire or cable pre-coated with a hot melt adhesive that simply needs to be activated by the application of sufficient heat for a sufficient amount of time immediately before installation. Rolls or cartridges of wire or cable pre-coated with the hot melt adhesive are provided. The hot melt adhesive coated wire or cable is fed through a heated chamber, preferably a tip on a portable heating device such as a battery operated soldering iron, which activates the pre-coated hot melt adhesive prior to utilizing the heating tip to apply pressure to the adhesive wire directly to a wall or ceiling thereby adhering the fiber, wire or cable to the desired surface. 1. A method of installing a hot-melt adhesive coated cable to a surface , comprising:providing a length of cable pre-coated with a hot-melt adhesive;providing a heating device, configured for heating said cable pre-coated with hot melt adhesive with sufficient heat to cause said hot-melt adhesive to become softened and adhere to a surface; andapplying sufficient pressure to said adhesive softened cable pre-coated with a hot-melt adhesive to adhere said cable to said surface.2. The method of claim 1 , wherein said cable has a diameter of between 0.9 and 1.9 mm.3. The method of claim 2 , wherein said hot-melt adhesive is applied to said cable in a thickness of between 300 and 400 μ.4. The method of claim 1 , wherein said cable pre-coated with a hot-melt adhesive includes a wax coating over said hot-melt adhesive coating.5. The method of claim 1 , wherein said cable is a single fiber claim 1 , fiber optic cable.6. The method of claim 1 , wherein said cable is a multiple fiber claim 1 , fiber optic cable.7. The method of claim 1 , wherein said heating device comprises a heating tool including a heating and installation tip claim 1 , wherein said heating and installation tip includes a slide cover having at ...

PEDIATRIC SUPPORT SYSTEM AND METHOD FOR MEDICAL IMAGING

A pediatric patient support system is provided. The system includes a support extension configured to be removably coupled to a cradle of a table, wherein the support extension includes radial supports extending in a radial direction relative to a longitudinal axis of the cradle. The system includes a pair of rods, wherein each rod is coupled to a respective radial support and extends substantially parallel to the longitudinal axis. The system includes a patient support disposed between and coupled to the rods, the patient support being configured to support a pediatric patient, wherein the patient support is configured to move axially relative to the longitudinal axis along the rods to move the pediatric patient in and out of a central bore of a medical imaging system. 1. A pediatric patient support system comprising:a support extension configured to be removably coupled to an end of a cradle of a table, wherein the support extension comprises a pair of radial supports extending in a radial direction relative to a longitudinal axis of the cradle;a pair of rods, wherein each rod of the pair of rods is coupled to a respective radial support of the pair of radial supports and extends substantially parallel to the longitudinal axis; anda patient support disposed between and coupled to the pair of rods, the patient support being configured to support a pediatric patient, wherein the patient support is configured to move axially relative to the longitudinal axis to move the pediatric patient in and out of a central bore of a medical imaging system.2. The pediatric patient support system of claim 1 , wherein the pediatric patient support system is solely supported by the cradle of the table.3. The pediatric patient support system of claim 2 , wherein when the patient support is disposed within the central bore the end of the cradle remains outside a path of radiation emitted by a radiation source during imaging.4. The pediatric patient support system of claim 1 , wherein ...

FIBER OPTIC WIRE SPLICE ENCLOSURE

A system and method for securely holding a fiber optic cable splice in place and for creating a watertight splice by encapsulating two or more fiber optic cables having one or more spliced fiber optic strands in an enclosure with an encapsulant to create a permanent, watertight, fiber-optic splicing system and method. 1. A fiber optic drop cable splice kit , comprising:a fiber cable splice enclosure adapted to be filled with an encapsulating compound, said enclosure having a top cover portion and a bottom portion, said enclosure including a first open end region and a second open end region disposed on an opposite end of said enclosure from said first end region, said bottom portion including a first surface having a first longitudinal edge region and a second longitudinal edge region, said second longitudinal end region disposed on an opposite side of said first surface from said first longitudinal edge region;said first longitudinal edge region in said bottom portion including at least a first cable engagement region and said second longitudinal edge region including at least a second cable engagement region, each of said first and second cable engagement regions forming a fiber optic drop cable engagement region, said fiber optic drop cable engagement region configured for engaging with at least first and second fiber optic drop cables, each said first and second fiber optic drop cable including at least one fiber strand to be spliced, each of said first and second cable engagement regions including a cable retention device engagement region configured for engaging with a cable retention device configured for retaining a fiber optic cable in place in said first and second cable engagement regions;a plurality of spacer ribs disposed on said first surface of said bottom portion, and configured for supporting one or more fiber optic wire disposed in said enclosure in spaced relationship with the first surface;at least one self-adhesive area disposed on said first ...

MUSICAL WATER INSTRUMENT OR WATER FILLED INSTRUMENT HAVING RIGID PIPES CONNECTED TO ELASTIC OR RIGID MEDIA

A musical instrument or multimedia input device is disclosed. User input is by hitting or striking water in order to produce an at least partially transient acoustic disturbance, vibrations, or change in the water. In one embodiment rigid pipes of various lengths or diameters emit fluid for being struck by a user at an open end of each pipe. The other end of each pipe is connected to an elastic tubing or other elastic medium, such as a diaphragm or bulb, resulting in a hydraulic resonator. In another embodiment the resonators are formed from variously sized bottles or flasks encased in cement, except for the mouths of the bottles. Each hydraulic resonator may be fitted with a sensor that senses the vibrations in the water and amplifies the vibrations into a sound reproduction system, such as an entirely acoustic impedance matcher or an electrical amplification system. 1. A liquid-based musical instrument , said instrument including one or more pipes each for being filled with liquid hydraulic fluid , each pipe having an end for being hydraulically open , and an end for connection to an hydraulic reservoir , said instrument also having one or more hydraulic reservoirs , each reservoir end of each pipe being connected to an hydraulic reservoir , said instrument also including a transformer for transforming vibrations in the hydraulic fluid to vibrations in air surrounding said instrument when the instrument is played.2. The instrument of claim 1 , where said one or more pipes are each a neck of a bottle claim 1 , and said one or more reservoirs is a bulb of the bottle claim 1 , and said transformer comprises an acoustic impedance matching device.3. The instrument of claim 2 , where said transformer includes an underwater electronic listening device for being inside of each of said bottles.4. The instrument of claim 2 , where said reservoirs are elastic elements formed from said bulbs of said bottles.5. The instrument of claim 2 , where said reservoirs comprise ...

ADJUSTABLE ROUND CABLE SLITTER

An adjustable cable slitter includes two components each comprising a main body portion, a coupling device at one end of the main body portion and a T-shaped handle disposed at an opposite end of the main body portion. The coupling device couples the two components together allowing the two components to rotate and be expanded. A channel runs along an interior length of each of the main body portions. A blade housing on at least one of the components of the main body portion securely holds a knife blade with a predetermined amount of cutting edge protruding into the channel. The knife blade tip can be oriented to cut a circumferential cut in the cable sheath or a longitudinal cut along the length of the cable. The exposed portion of the blade pierces the sheath cutting the cable near its end or in a middle of the cable. 1. A device for cutting an exterior layer of a cable , the device comprising:a first component and a second component, each of the first and second components having a main body portion having a length, an exterior side, an interior side, a first end and a second end opposite the first end;each of the first and second components including a channel that runs along the entire length of the interior side of the first and second components;wherein the first end of the main body portion of each of the first and second components has a T-shaped handle and wherein the second end of the main body portion of the first component is designed to releasably, rotatably and expandably interconnect with the second end of the main body portion of the second component, and wherein the first and second rotatably interconnected components are configured for receiving a cable in the channel in the interior side of the first and second components; andat least one blade housing, located on the exterior side of at least one of the first and second components within the main body portion, the at least one blade housing configured for securely, rotatably and removably ...

SYSTEM AND METHOD FOR APPLYING AN ADHESIVE COATED CABLE TO A SURFACE

A system and method for installing a fiber or cable on a wall or ceiling of a structure includes providing a fiber, wire or cable pre-coated with a hot melt adhesive that simply needs to be activated by the application of sufficient heat for a sufficient amount of time immediately before installation. Rolls or cartridges of wire or cable pre-coated with the hot melt adhesive are provided. The hot melt adhesive coated wire or cable is fed through a heated chamber, preferably a tip on a portable heating device such as a battery operated soldering iron, which activates the pre-coated hot melt adhesive prior to utilizing the heating tip to apply pressure to the adhesive wire directly to a wall or ceiling thereby adhering the fiber, wire or cable to the desired surface. 1. An adhesive coated cable arrangement comprising:a cable including a signal carrying element surrounded by at least one layer having an exterior surface; anda thermally activated adhesive bonded to the exterior surface with the assistance of a tie-layer, the thermally activated adhesive being suitable for adhering the cable to a surface of a wall or ceiling when activated.2. The adhesive coated cable arrangement of claim 1 , wherein the thermally activated adhesive covers a majority of the exterior surface.3. The adhesive coated cable arrangement of claim 2 , wherein the cable has a round transverse cross-sectional shape.4. The adhesive coated cable arrangement of claim 3 , wherein the thermally activated adhesive provides 360 degree coverage of the cable.5. The adhesive coated cable arrangement of claim 1 , wherein the cable has a round transverse cross-sectional shape claim 1 , wherein the signal carrying element includes an optical fiber claim 1 , wherein the optical fiber is surrounded by a buffer layer that includes polyvinyl chloride claim 1 , and wherein the buffer layer defines the exterior surface.6. The adhesive coated cable arrangement of claim 5 , wherein the cable has an outer diameter less ...

CATHETER ASSEMBLY

Novel catheter constructions comprising thin covering or wrapping materials such as polymer films. A catheter provided with a guidewire catheter lumen having a thin covering that is easily punctured by a guidewire at virtually any desired point along the catheter length. The thin covering may be integral with the catheter shaft, or may be a separate component that covers only the portion of the catheter shaft immediately adjacent the outer portion of the guidewire lumen, or may be a thin tubular construct that surrounds the entire catheter shaft. Moreover, polymer film can be used in combination with one or more elements to produce novel catheter constructions. 1. A medical device comprising:a longitudinally extending tube including a polymer film, wherein the polymer film is wrapped such that a thickness of the wrapped polymer film varies along a length of the longitudinally extending tube and such that the longitudinally extending tube has a substantially constant outer diameter and an inner diameter that varies along the length of the longitudinally extending tube.2. The medical device of claim 1 , wherein the polymer film is in the form of a continuously wrapped polymer film tape.3. The medical device of claim 1 , wherein the polymer film is in the form of a plurality of discrete polymer film tape wraps.4. The medical device of claim 1 , wherein the inner diameter of the longitudinally extending tube tapers along the length of the longitudinally extending tube.5. The medical device of claim 4 , wherein the thickness of the wrapped polymer film progresses continuously from a first end of the longitudinally extending tube to a second end of the longitudinally extending tube such that a thickness of the wrapped polymer film at the first end of the longitudinally extending tube is greater than a thickness of the wrapped polymer film at the second end of the longitudinally extending tube.6. The medical device of claim 5 , wherein a number of wraps of the wrapped ...

AUDIO SIGNAL DRIVEN ANALOG FLAME DISPLAY

A “flame show” is responsive to an audio input signal such as music. A base unit including an analog base unit controller circuit is arranged to receive an audio input signal and generate an analog control signal that is responsive to the audio input signal. The analog control signal is distributed, by wire or wireless, to one or more flame display units such as a “tiki torch.” Each flame display unit has a fuel source, and a proportional valve for controlling an amount of fuel supplied to a burner. Preferably, the control signal controls a gate terminal of a MOSFET semiconductor device, which in turn is coupled to control current in the proportional valve each each unit. By deploying multiple flame display units, all coupled to the same base unit, all of the flame display units contribute synchronously to the overall flame show. 1. A system comprising:a base unit including an analog base unit controller circuit arranged to receive an audio input signal and generate an analog control signal that is responsive to the audio input signal;a control wire connectable to the base unit to distribute the analog control signal; anda flame display unit electrically connectable to the control wire to receive the analog control signal;the flame display unit including a combustible fuel source to generate an open flame;and the flame display unit including a proportional valve to control flow of fuel from the fuel source so as to controllably vary a height of the open flame responsive to the analog control circuit during operation of the flame display unit.2. The system of wherein:the flame display unit includes a flame control circuit arranged to receive the analog control signal and generate an analog valve position signal; andthe flame control circuit is coupled to utilize the analog valve position signal to control electrical current in the proportional valve during operation, thereby producing an active flame show responsive to the audio input signal.3. The system of wherein: ...

Systems and methods for account agnostic transaction routing

Systems and methods for account agnostic transaction routing are disclosed. According to one embodiment, in an information processing device comprising at least one computer processor, a method for account agnostic transaction routing may include: (1) receiving an identifier for a first financial instrument for a transaction being conducted at a point of transaction; (2) retrieving a plurality of financial instruments associated with the identifier, the plurality of financial instruments comprising the first financial instrument; (3) retrieving at least one transaction routing rule associated with the plurality of financial instruments, the transaction routing rule specifying a condition for using one of the plurality of financial instruments; (4) identifying one of the plurality of financial instruments for conducting the transaction based on the transaction and the transaction routing rule; and (5) settling the transaction with the identified financial instrument.

Multi-Station System for Pressure Ulcer Monitoring and Analysis

A multi-patient pressure monitoring system for monitoring, prevention, and analysis of pressure ulcers. The system includes a server, monitoring stations, and mobile communication terminals. Each of the monitoring stations are configured to detect physical properties including at one of pressure, temperature, and moisture, in relation to a respective contact surface. The server includes a controller configured for: receiving inputs including the detected physical properties from the monitoring stations, determining a risk value at each monitoring station using the risk assessment model based on the received inputs and patient information, determining a priority of each monitoring station in dependence of the determined risk value, and communicating the determined priority of the stations to an output interface. The server can track and correlate radio frequency identification (RFID) activation between the mobile communication terminal and one of the stations, the time of the proximity being associated with the patient turn at the station. 1. A monitoring station for monitoring pressure at a contact surface , comprising:a plurality of sensors for detecting physical properties of the contact surface, the sensors including at least one of pressure sensors, temperature sensors, and moisture sensors;a communication subsystem for communicating with a server device over a network;a controller operably connected to the sensors and for communicating information through the communication subsystem to the server device based on the physical properties detected by the sensors; anda short-range communication device operably connected to the controller and which contains at least identification information of the monitoring station, the identification information automatically being sent to a mobile communication terminal in response to proximity detection of the mobile communication terminal,wherein the proximity detection only occurs in association with performance of a ...

WEARABLE CLOSED LOOP AI WITH LIGHT BASED BRAIN SENSING: TECHNOLOGY AT THE BOUNDARY BETWEEN SELF AND ENVIRONS

Means, apparatus, and methods of sensor/sensory, meta-sensory, and meta-sensing user-interfaces are provided. In one embodiment, smart headwear senses at least one health or mental health parameter of a wearer of the smart headwear. In one embodiment a smart eyeglass senses brain activity. In another embodiment a wearable device senses blood flow, and indirectly through artificial intelligence, other health parameters such as fever, brain health, mental health, and the like. In another embodiment, a wearable AI (Artificial Intelligence) device has associated with it a meta-lock-in amplifier, i.e. a second lock-in amplifier responsive to an output of a first lock-in amplifier, where the first lock-in amplifier is referenced to at least one alternating current electrical signal driving a light source, and the second lock-in amplifier is referenced to an output of the first lock-in amplifier. In another embodiment, a collective of users engage in a gamelike activity that promotes improved physical and mental health. When paired with a camera a wearer can automatically capture rushing and dragging moments during their day as blood rushes or drags or maintains tempo in their brain. When paired with a fuzzy display a wearer can gain insight in real-time to their cognitive state. 1. A cybernetic human-machine interface , said interface including:at least one wearable sensor to sense a mental state of a wearer of said user interface;at least one feedback mechanism to provide real-time feedback and effect for the wearera processor for processing output from said sensor;a transmitter for transmitting computational output and feedback to a secondary computational devicea receiver for receiving input from a secondary computation devicea computer implemented method for determining a value of change in oxygenated, de-oxygenated and total hemoglobin from a series of LEDs and photodiodes.a computer implemented method for classification of hemodynamic signal or multiple hemodynamic ...

Grinder-mixer controls

Remote control of unloading augers on agricultural grinder-mixers is accomplished by hydraulic motors arranged to adjust the height of the remote end of the auger and to rotate its position in the horizontal plane. These motors are each controlled by solenoid operated valves in the hydraulic system and the valves are operated by sets of electrical controls located in the tractor cab and in proximity to the unloading auger.

Thermoplastic urethane elastomeric alloys

Thermoplastic urethane elastomeric alloys are obtained by melt compounding at least one first component that is a polyurethane elastomer having at least one plasticizer reacted therein, this first component being formed by heating a reaction mixture comprising at least one isocyanate having a functionality of less than about 2,2, at least one long chain polyol, at least one chain extender and at least one plasticizer in specified amounts at a temperature of at least about 330 °F (165.6 °C), with at least one second component that is another thermoplastic elastomer not within the definition of the first component.

Thermoplastic urethane elastometric alloys

Thermoplastic urethane elastomeric alloys are obtained by melt compounding at least one first component that is a polyurethane elastomer having at least one plasticizer reacted therein, this first component being formed by heating a reaction mixture comprising at least one isocyanate having a functionality of less than about 2.2, at least one long chain polyol, at least one chain extender and at least one plasticizer in specified amounts at a temperature of at least about 330° F. (165.6° C.), with at least one second component that is another thermoplastic elastomer not within the definition of the first component.

Thermoplastic urethane elastomeric alloys

Thermoplastic urethane elastomeric alloys are obtained by melt compounding at least one first component that is a polyurethane elastomer having at least one plasticizer reacted therein, this first component being formed by heating a reaction mixture comprising at least one isocyanate having a functionality of less than about 2,2, at least one long chain polyol, at least one chain extender and at least one plasticizer in specified amounts at a temperature of at least about 330 °F (165.6 °C), with at least one second component that is another thermoplastic elastomer not within the definition of the first component.

Thermoplastic urethane elastomeric alloys

Thermoplastic urethane elastomeric alloys are obtained by melt compounding at least one first component that is a polyurethane elastomer having at least one plasticizer reacted therein, this first component being formed by heating a reaction mixture comprising at least one isocyanate having a functionality of less than about 2.2, at least one long chain polyol, at least one chain extender and at least one plasticizer in specified amounts at a temperature of at least about 330° F. (165.6° C.), with at least one second component that is another thermoplastic elastomer not within the definition of the first component.

Fastening device

A device for fastening surfaces together in an effective, efficient, and preferably reversible bond is disclosed. This device is particularly useful in the construction industry for fastening roll goods, such as wall coverings, or mill work, such as moldings, to surfaces, such as walls. The fastening device comprises a susceptor sheet, preferably having a thickness of no greater than about 2 mils, and a heat-activateable adhesive on at least one surface of the susceptor, wherein adhesive is placed on the substrate in a very carefully and specifically-defined manner. The fastening device is activated by induction heating, preferably by a hand-held induction tool. The method of fastening surfaces together utilizing the fastening device described above is also disclosed.

Catheter balloons with integrated non-distensible seals

A catheter balloon with integral non-distending regions having a plurality of layers which wind around the balloon material and overlap to form an angle of between 45 and 90 degrees relative to each other upon inflation, and methods of making the non-distending regions are provided.

System for providing cardless payment

The method and system of the invention provide a variety of techniques for using a selected alias and a selected personal identification entry (PIE) in conjunction with use of a transaction card, such as a credit card, debit card or stored value card, for example. A suitable number or other identification parameter is selected by the account-holder as an alias. The account-holder is then required to choose a PIE for security purposes. The alias is linked to the account-holder's credit card number via a database. When the account-holder enters into a transaction with a merchant, the physical card need not be present. The account-holder simply provides his or her alias and then the PIE. This can be done at any point of sale such as a store, catalog telephone order, or over the Internet. The alias and PIE are entered and authorization is returned from the credit card company.

Fault containment system for multiprocessor with shared memory

A multiprocessor system has a plurality of processing cells, each including a processor and memory, interconnected via a network. The memories respond to requests by the processors for accessing data and, absent fault, transmitting it in response packets to at least to the requesting processors. A fault containment element responds to at least certain faults during access or transmission of a datum for including within the respective response packet a fault signal that prevents the requestor from accessing the datum. If a fault is detected in a datum not previously detected as faulty, a marking element can include a "marked fault" signal in the response packet. Whereas, it can include an "unmarked fault" signal when it detects a fault associated with a requested datum, but not specifically isolated to that datum. When a request is made for a datum which had previously been detected as faulty, the marking element can include in the response packet a "descriptor fault" signal. This facilitates identification of a particular source of an error and prevents that error from propagating to other processing cells.

CYCLIC SULFONAMIDE DERIVATIVES AS MONOAMINE RECAPTATION INHIBITORS

SE REFIERE A DERIVADOS DE SULFONAMIDA CICLICOS DE FORMULA (I), EN DONDE m ES DE 0 A 4; n ES DE 0 A 2; p ES DE 0 A 1; q ES DE 1 A 2; v ES DE 0 A 2; X ES C(R11)2, N(R12), O u S(O)v; Y ES C(R11)2, N(R12) O >C=C(R17)2; R1 ES ARILO O HETEROARILO SUSTITUIDO CON R5; R2 ES H, ALQUILO(C1-C6), ENTRE OTROS; R3 ES H, ALQUILO(C1-C6), ALCANOL(C1-C6), ENTRE OTROS; O R2 Y R3 JUNTOS AL N AL QUE ESTAN UNIDOS FORMAN UN MONO O BICICLICO HETEROCICLICO DE 3 A 12 ATOMOS; R4 ES H, ALQUILO(C1-C6), ARILO SUSTITUIDO CON R8; ARILALQUILO(C1-C6), ENTRE OTROS; R9 ES INDEPENDIENTEMENTE ALQUILO(C1-C6), ALCOXI, HALO, ENTRE OTROS; R13 ES H, ALQUILO(C1-C8), HALURO, HIDROXI, O ARILO SUSTITUIDO; R15 ES H, ALQUILO(C1-C4) O HALURO. SON SELECCIONADOS: 3-(2,2-DIOXIDO-1-FENIL-3,4-DIHIDRO-1H-2,1-BENZOTIAZIN-3-IL)-N-METILPROPAN-1-AMINA, 1-FENIL-3-(3-PIRROLIDIN-1-ILPROPIL)-3,4-DIHIDRO-1H-2,1-BENZOTIAZINA 2,2-DIOXIDO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION, ESTOS COMPUESTOS SON INHIBIDORES DE LA RECAPTACION DE MONOAMINA, SIENDO UTILES EN EL TRATAMIENTO DE TRASTORNOS DE DEPRESION, TRASTORNOS DE COMPORTAMIENTO ENDOGENO, TRASTORNO COGNICITIVO, SINTOMAS VASOMOTRICES, DISFUNCION SEXUAL O AFECCIONES DE DOLOR

SECONDARY LATCH OF HITCH SADDLE

Ensemble verrou secondaire (220) pour une sellette (10), la sellette (10) comprenant une plaque d'attelage (30) pourvue d'une fente s'ouvrant vers l'arrière (135) pour recevoir un pivot d'attelage (111) d'une remorque, et d'un élément de verrouillage primaire coulissant transversalement (20) pour maintenir le pivot d'attelage (111) à l'intérieur de la fente (135) . L'ensemble comprend une barre d'accouplement (210) raccordée de manière pivotante au niveau de son centre à l'élément de verrouillage primaire (20), ainsi qu'une barre de traction orientée transversalement (217) et raccordée au niveau d'une extrémité intérieure à l'extrémité avant de la barre d'accouplement (210) . La barre de traction (217) comprend une patte de décalage arrière (219). Un loquet (221) est raccordé, approximativement en son centre, à l'extrémité avant de la barre d'accouplement (210), et est raccordé en un point décalé vers l'arrière et vers l'intérieur par rapport au premier raccord pivotant à la patte de décalage (219). Un cran (225) s'étend depuis une paroi transversale comprise dans la plaque d'attelage de telle manière qu'il se situe dans le même plan horizontal que ledit loquet (221) . A secondary lock assembly (220) for a fifth wheel (10), the harness (10) comprising a hitch plate (30) having a rearwardly opening slot (135) for receiving a kingpin ( 111) of a trailer, and a transversely sliding primary locking element (20) for holding the kingpin (111) within the slot (135). The assembly includes a coupling bar (210) pivotally connected at its center to the primary locking member (20) and a transversely oriented drawbar (217) connected to the an inner end at the forward end of the tie rod (210). The drawbar (217) includes a rear shift tab (219). A latch (221) is connected, approximately at its center, to the front end of the tie bar (210), and is connected at a point shifted rearwardly and ...

Device and method for reducing false indications of leakage in a double-wall tank

"DEVICE AND METHOD FOR REDUCING FALSE INDICATIONS OF LEAKAGE IN A DOUBLE-WALL TANK" ABSTRACT A device and a method are provided for reducing false indications of leakage between the inner and outer walls of a double-wall tank. The device comprises means for reducing contact between a sensor assembly and condensation which forms between the walls, preferably comprising an isolation stand-off flange secured around a portion of the sensor assembly. The method comprises spacing the sensor assembly from the walls to reduce the potential for contact between the sensor assembly and condensation.

Parallel processing apparatus and method for utilizing tiling

Abstract An improved parallel processing apparatus and method executes an iterative sequence of instructions by arranging the sequence into substasks and allocating those substasks to processors. This division and allocation is conducted in such a manner as to minimize data contention among the processors and to maximize the locality of data to them. The improved apparatus and method have application to variety of multiprocessor systems, including those which are massively parallel.

Ram for indirect metal extrusion press

Brake shoe lining for de-icing brake surfaces

Fifth wheel slide rail and related method of assembly

A slide rail assembly for providing adjustable positions for fifth wheel hitches including a slide rail having feet extending downward from the underside of the slide rail, adjacent feet being separated by a detent for receiving a slide locking mechanism, each of the feet having a recesses located at the bottom inside corner of each foot, respecting the assembly. The slide rail also comprises teeth with gaps therebetween, where the gaps are vertically aligned with the recesses.

Polar quinazolines as liver x receptors ( lxrs ) modulators

Disclosed are polar quinazoline-based modulators of Liver X receptors (LXRs) and related methods. The modulators include compounds of formula (I): INSERT FORMULA HERE AS IT APPEARS IN WRITTEN FORM IN THE SPECIFICATION (I) in which, R1, R2, R3, R4, R5, R6, R22, R23, R24, R25, R26, R27, R28, R29, W, W1, W2, Ra, Rb, Rc, Rd, Re, Rf, Rg, Rh, Ri, Rj, Rm, Rn, Ro, Rp, Rq, Rr, Rs, Rt, Ru, and n can be as defined anywhere herein. In general, these compounds can be used for treating or preventing one or more diseases, disorders, conditions or symptoms mediated by LXRs.

Electric switch and contact structure therefor

Brake system development tool having a mechanism for setting different pedal ratios

A brake system development tool ( 10 ) providing adjustment of pedal ratio in a brake pedal mechanism without having to disassemble the mechanism and replace parts. A positioning mechanism carried by the pedal arm ( 20 ) positions the pedal arm and the brake pedal pivot shaft ( 16 ) relative to the pushrod shaft ( 18 ) to set the distance between the axis of the brake pedal pivot shaft and the axis of the pushrod shaft.

Fabric router with flit caching

In a fabric router, flits are stored on chip in a first set of rapidly accessible flit buffers, and overflow from the first set of flit buffers is stored in a second set of off-chip flit buffers that are accessed more slowly than the first set. The flit buffers may include a buffer pool accessed through a pointer array or a set associative cache. Flow control between network nodes stops the arrival of new flits while transferring flits between the first set of buffers and the second of buffers.

Fifth wheel coupling assembly with removable locking mechanism.

Adjustable height fifth wheel hitch

An adjustable height fifth wheel hitch is provided. The fifth wheel hitch comprises a pedestal and a fifth wheel hitch assembly. The fifth wheel hitch assembly includes journal bearings which pivotally connect with risers of the pedestal. The risers of the pedestal include a plurality of openings located at different levels. The height of the fifth wheel assembly in relation to the tractor may be adjusted by aligning openings in the journal bearings with co-level openings in the risers and inserting a mounting pin through such openings.

Improvements in and relating tothe construction of removable covers, sheds or garages

High-speed packet switching apparatus and method

An improved digital packet switching apparatus enabling enhanced packet transmission and high bandwidth packet transfer. The digital packet switching methods and apparatus permit selectively switching digital signal packet between a set of nodes. The invention includes multiple processing cells, each having a processor coupled to an associated content-addressable memory element. Packet processors, electrically coupled to the memory elements, selectively receive packets from the nodes and transmit the packets into at least one of the plural memory elements; or receive packets from the memory elements and transmit the packets to at least one of the nodes. One aspect of the invention includes memory management elements, coupled to the memory elements, for accessing one or more of the information-representative signals stored in the plural memory elements. The in-cell processors can include access request elements for requesting access to an information-representative signal. The access request element can also generate an ownership-request signal to request priority access to an information-representative signal. In another aspect of the invention, the memory element associated with the requesting processor includes control elements for selectively transmitting the access-request signal to the memory management element. The memory management elements can also include memory coherence elements. These coherence elements respond to certain ownership-request signals by exclusively allocating physical storage space in the memory element associated with the requesting processor and storing the requested information-representative signal therein.

Medical treatments based on anamorelin

Methods of treating cancer related conditions using anamorelin are described. The principal embodiment relates to the unique condition of patients defining this condition by treating cachexia in a human cancer patient, comprising administering to said patient a therapeutically effective amount of anamorelin for a therapeutically effective period of time, and observed surprising ability of anamorelin to increase lean body mass in this population.

Fifth wheel assembly

A fifth wheel assembly comprises a fifth wheel having a plurality of journal bearings extending generally downward from its underside, and an “I-shaped” transverse beam member for mounting the assembly to a truck frame. The beam member is dimensioned to span across parallel longitudinal truck frame members and it includes mounting flanges extending generally downward from either lateral side where the mounting flanges have a plurality of apertures for receiving suitable fasteners inserted therein for mounting said beam member to the truck frame members. The transverse member also includes a plurality of pivot bearing pairs to receive the journal bearings of the fifth wheel which is coupled thereto by a trunnion.

ANAMORELINE BASED MEDICAL TREATMENTS

Se describen procedimientos para la fabricación de medicamentos útiles para el tratamiento de afecciones relacionadas con el cáncer usando anamorelina. La modalidad principal se relaciona con la afección única de pacientes que la definen mediante el tratamiento de la caquexia en un paciente humano con cáncer, que comprende el uso de una cantidad terapéuticamente efectiva de anamorelina durante un período terapéuticamente efectivo, y la sorprendente capacidad observada de la anamorelina de aumentar la masa corporal magra de esta población.

System and method for applying an adhesive coated cable to a surface

A system and method for installing a fiber or cable on a wall or ceiling of a structure includes providing a fiber, wire or cable pre-coated with a hot melt adhesive that simply needs to be activated by the application of sufficient heat for a sufficient amount of time immediately before installation. Rolls or cartridges of wire or cable pre-coated with the hot melt adhesive are provided. The hot melt adhesive coated wire or cable is fed through a heated chamber, preferably a tip on a portable heating device such as a battery operated soldering iron, which activates the pre-coated hot melt adhesive prior to utilizing the heating tip to apply pressure to the adhesive wire directly to a wall or ceiling thereby adhering the fiber, wire or cable to the desired surface.

I/O driver for integrated circuit with output impedance control

An I/O driver has v/i characteristic control for maintaining a substantially flat output impedance response using a transmission gate configuration at an I/O output pad. The configuration includes a linear resistive element electrically connected at an I/O pad for limiting a processed data I/O signal, an active impedance element for receiving and processing the data signal, which comprises data represented by a series of voltage state transitions, and pull-up and pull-down array calibration words, for generating and outputting a processed I/O output signal to the resistive element to output a substantially flat v/i response at switching of the data signal.

Fifth wheel coupling assembly with removable locking mechanism

A removable locking mechanism for a fifth wheel hitch is provided which includes a mounting plate removably attachable within a fifth wheel chassis formed to support a fifth wheel hitch plate that has an aperture in the load surface thereof. The mounting plate is formed with a u-shaped throat dimensioned to receive a trailer kingpin and a top surface configured to be co-planar with the fifth wheel hitch plate load surface when seated within the chassis. A locking mechanism for retaining the kingpin against said closed end of the throat is mounted to the underside of the mounting plate and includes a cam arm; and a bumper arm pivotally attached to the cam arm configured to engage a bumper stop formed in the mounting plate underside; a sliding jaw member slidably mounted to the cam arm; and a secondary lock member for preventing unintended disengagement of the lock mechanism.

Bistable magnetic decision summing device

Medical treatments based on anamorelin

Methods of treating cancer related conditions using anamorelin are described. The principal embodiment relates to the unique condition of patients defining this condition by treating cachexia in a human cancer patient, comprising administering to said patient a therapeutically effective amount of anamorelin for a therapeutically effective period of time, and observed surprising ability of anamorelin to increase lean body mass in this population.

Trifluoromethyl-containing phenylsulfonamide beta amyloid inhibitors

A compound of Formula (I), or pharmaceutically acceptable salts and/or hydrates or prodrugs thereof, wherein Formula (I) has the structure: is provided, wherein R 1 -R 7 are defined herein. These compounds are useful in medicaments for treating a disease selected from the group consisting of Alzheimer's disease, amyloid angiopathy, cerebral amyloid angiopathy, systemic amyloidosis, hereditary cerebral hemorrhage with amyloidosis of the Dutch type, inclusion body myositis, mild cognitive impairment (MCI) and Down's syndrome, in a subject.

Medical treatments based on anamorelin

Methods of treating cancer related conditions using anamorelin are described. The principal embodiment relates to the unique condition of patients defining this condition by treating cachexia in a human cancer patient, comprising administering to said patient a therapeutically effective amount of anamorelin for a therapeutically effective period of time, and observed surprising ability of anamorelin to increase lean body mass in this population.

Irregular network

Irregularities are provided in at least one dimension of a torus or mesh network for lower average path length and lower maximum channel load while increasing tolerance for omitted end-around connections. In preferred embodiments, all nodes supported on each backplane are connected in a single cycle which includes nodes on opposite sides of lower dimension tori. The cycles in adjacent backplanes hop different numbers of nodes.

Audio signal driven analog flame display

A “flame show” is responsive to an audio input signal such as music. A base unit including an analog base unit controller circuit is arranged to receive an audio input signal and generate an analog control signal that is responsive to the audio input signal. The analog control signal is distributed, by wire or wireless, to one or more flame display units such as a “tiki torch.” Each flame display unit has a fuel source, and a proportional valve for controlling an amount of fuel supplied to a burner. Preferably, the control signal controls a gate terminal of a MOSFET semiconductor device, which in turn is coupled to control current in the proportional valve each each unit. By deploying multiple flame display units, all coupled to the same base unit, all of the flame display units contribute synchronously to the overall flame show.

Thermoplastic urethane elastomeric alloys

Thermoplastic urethane elastomeric alloys are obtained by melt compounding at least one first component that is a polyurethane elastomer having at least one plasticizer reacted therein, this first component being formed by heating a reaction mixture comprising at least one isocyanate having a functionality of less than about 2,2, at least one long chain polyol at least one chain extender and at least one plasticizer in specified amounts at a temperature of at least about 330 .degree.F (165.6 .degree.C), with at least one second component that is another thermoplastic elastomer not within the definition of the first component.

Method and structures for dual depth oxygen layers in silicon-on-insulator processes

A semiconductor structure, and associated method of fabrication, comprising a substrate having a continuous buried oxide layer and having a plurality of trench isolation structures. The buried oxide layer may be located at more than one depth within the substrate. The geometry of the trench isolation structure may vary with depth. The trench isolation structure may touch or not touch the buried oxide layer. Two trench isolation structures may penetrate the substrate to the same depth or to different depths. The trench isolation structures provide insulative separation between regions within the substrate and the separated regions may contain semiconductor devices. The semiconductor structure facilitates the providing of digital and analog devices on a common wafer. A dual-depth buried oxide layer facilitates an asymmetric semiconductor structure.

Fifth wheel secondary lock

A secondary lock assembly for a fifth wheel, where the fifth wheel includes a hitch plate with a rearward opening slot to receive a trailer kingpin and a transversely sliding primary locking member for retaining the kingpin within the slot. The assembly comprises a tie bar pivotally connected at its middle to the primary locking member and a transversely oriented pull bar pivotally connected at an inner end to the forward end of the tie bar. The pull bar comprises a rearward offset tab. A latch is pivotally connected roughly at the center of the latch to the forward end of the tie bar, and also pivotally connected at a point rearwardly and inwardly offset from the first pivoting connection to the offset tab. A detent extends from a transverse wall comprised in said hitch plate such that said detent lies in the same horizontal plane as said latch.

Spinning top and support therefor

Fastening device

A device for fastening surfaces together in an effective, efficient, and preferably reversible bond is disclosed. This device is particularly useful in the construction industry for fastening roll goods, such as wall coverings, or mill work, such as moldings, to surfaces, such as walls. The fastening devic e comprises a susceptor sheet, preferably having a thickness of no greater tha n about 2 mils, and a heat-activateable adhesive on at least one surface of th e susceptor, wherein adhesive is placed on the substrate in a very carefully a nd specifically-defined manner. The fastening device is activated by induction heating, preferably by a hand-held induction tool. The method of fastening surfaces together utilizing the fastening device described above is also disclosed.

Optical fiber installation at customer premises

Collapsible ashtray

COLLAPSIBLE ASHTRAY Abstract of the Invention A collapsible ashtray includes a pair of panels joined by a pleated sheet which defines an ash receptacle when the panels are pulled apart. The pleated sheet includes at least one step formed therein for holding lighted cigarettes. In one embodiment, the panels are joined to form a hinge, and the ashtray may be folded and unfolded along this hinge. In another embodiment, the panels are not joined so that the panels may be pulled apart in a parallel fashion.

Attaching a communication line to a target surface on or inside of a building

A communication line such as an optical fiber or cable is attached along a wall, ceiling, trim piece, or other target surface inside of a building by laying out the line from an applicator tool. An outer surface of the line is placed in a temporarily tacky condition as the line is laid out from the tool along the target surface. The temporarily tacky condition of the line is due at least in part to an adhesive component that is pre-applied to the outer surface of the line. The adhesive component is activated by an agent or medium that is associated with the applicator tool. The line becomes non-tacky after it is attached to the target surface.

Valve lock

Trifluoromethyl-containing phenylsulfonamide beta amyloid inhibitors

A compound of Formula (I), or pharmaceutically acceptable salts and/or hydrates or prodrugs thereof, wherein Formula (I) has the structure: is provided, wherein R 1 -R 7 are defined herein. These compounds are useful in medicaments for treating a disease selected from the group consisting of Alzheimer's Disease, amyloid angiopathy, cerebral amyloid angiopathy, systemic amyloidosis, hereditary cerebral hemorrhage with amyloidosis of the Dutch type, inclusion body myositis, mild cognitive impairment (MCI) and Down's syndrome, in a subject.

Collapsible ashtray

Multiprocessor system with shared memory

A digital data processing system includes a plurality of central processor units which share and access a common memory through a memory management element. The memory management element permits, inter alia. data in the common memory to be accessed in at least two modes. In the first mode, all central processing units requesting access to a given datum residing in memory are signalled of the datum's existence. In the second mode, only selected central processing units requesting access to a resident datum are notified that it exists, while others requesting access to the datum are signalled that it does not exist. The common memory can include a plurality of independent memory elements, each coupled to and associated with, a respective one of the central processing units. A central processing unit can include a post-store element for effecting the transfer of copies of data stored in its associated memory element to a memory element associated with another central processing unit.

System and method for applying an adhesive coated cable to a surface

A system and method for installing a fiber or cable on a wall or ceiling of a structure includes providing a fiber, wire or cable pre-coated with a hot melt adhesive that simply needs to be activated by the application of sufficient heat for a sufficient amount of time immediately before installation. Rolls or cartridges of wire or cable pre-coated with the hot melt adhesive are provided. The hot melt adhesive coated wire or cable is fed through a heated chamber, preferably a tip on a portable heating device such as a battery operated soldering iron, which activates the pre-coated hot melt adhesive prior to utilizing the heating tip to apply pressure to the adhesive wire directly to a wall or ceiling thereby adhering the fiber, wire or cable to the desired surface.

Fiber optic drop wire splice kit

The present invention features a system and method for securely holding a fiber optic drop cable splice in place and for creating a watertight splice by encapsulating two or more fiber optic cables having one or more spliced fiber optic strands in an enclosure with an encapsulant to create a permanent, watertight fiber-optic splicing system and method.

Flip feram cell and method to form same

A method of forming an integrated ferroelectric/CMOS structure which effectively separates incompatible high temperature deposition and annealing processes is provided. The method of the present invention includes separately forming a CMOS structure and a ferroelectric delivery wafer. These separate structures are then brought into contact with each and the ferroelectric film of the delivery wafer is bonded to the upper conductive electrode layer of the CMOS structure by using a low temperature anneal step. A portion of the delivery wafer is then removed providing an integrated FE/CMOS structure wherein the ferroelectric capacitor is formed on top of the CMOS structure. The capacitor is in contact with the transistor of the CMOS structure through all the wiring levels of the CMOS structure.

Fiber optic wire splice enclosure

A system and method for securely holding a fiber optic cable splice in place and for creating a watertight splice by encapsulating two or more fiber optic cables having one or more spliced fiber optic strands in an enclosure with an encapsulant to create a permanent, watertight, fiber-optic splicing system and method.

System packaging for high performance computer applications

A cooling system for a host device affords enhanced reliability using multiple blower units mounted in parallel between a low pressure plenum and a high pressure plenum and a control system that senses when a blower unit is failing or has failed and responds by shutting down the failed unit and increasing the speed of the remaining blowers to maintain the air flow volume delivered to the cooling path. To maintain the integrity of the cooling air path while affording continuous operation of the host device, a spring biased closure door seals the access opening through which the blower is mounted when a blower unit is removed and displaced by the blower unit to an inoperative position against the biasing force of the spring when the blower unit is installed or replaced. To prevent recirculation through a vacated blower unit mounting space, a one way air flow device, in the form of a shutter assembly including plural pivoting louvers or vanes is mounted at the exhaust location of each blower. Thus the cooling air delivery is maintained and a blower unit can be removed for maintenance or replacement without interruption or impairment of host device operation.

Means and apparatus for acquiring, processing and combining multiple exposures of the same scene or objects to different illuminations

Fifth Wheel Secondary Lock

A secondary lock assembly for a fifth wheel, where the fifth wheel includes a hitch plate with a rearward opening slot to receive a trailer kingpin and a transversely sliding primary locking member for retaining the kingpin within the slot. The assembly comprises a tie bar pivotally connected at its middle to the primary locking member and a transversely oriented pull bar pivotally connected at an inner end to the forward end of the tie bar. The pull bar comprises a rearward offset tab. A latch is pivotally connected roughly at the center of the latch to the forward end of the tie bar, and also pivotally connected at a point rearwardly and inwardly offset from the first pivoting connection to the offset tab. A detent extends from a transverse wall comprised in said hitch plate such that said detent lies in the same horizontal plane as said latch.

Hammer mill

Calf-weaner.

Thermoplastic polyurethane-epoxy mixtures that develop cross-linking upon melt processing

The compositions of the invention are hot melt urethane compositions for application in the molten star at temperatures of from about 121.1°-232.2° C. having viscosities of less than 50,000 cps which upon cooling form an elastomeric solid.

Expansion of compact database for pattern inspector or writer

A laser pattern inspection and/or writing system which writes or inspects a pattern on a target on a stage, by raster scanning the target pixels. Inspection can also be done by substage illumination with non-laser light. A database, organized into frames and strips, represents an ideal pattern as one or more polygons. Each polygon's data description is contained within a single data frame. The database is transformed into a turnpoint polygon representation, then a left and right vector representation, then an addressed pixel representation, then a bit-mapped representation of the entire target. Most of the transformations are carried out in parallel pipelines. Guardbands around polygon sides are used for error filtering during inspection. Guardbands are polygons, and frames containing only guardband information are sent down dedicated pipelines. Error filtering also is done at the time of pixel comparisons of ideal with real patterns, and subsequently during defect area consolidation. Defect areas are viewed as color overlays of ideal and actual target areas, from data generated during real time. Defect areas can be de-zoomed to allow larger target areas to be viewed. An autofocus keeps the scanning laser beam in focus on the target. The inspection system is used to find fiducial marks to orient the target prior to raster scanning. IC bars are provided with alignment marks for locating each IC bar. Interferometers or glass scale encoders allow the stage position to be known.

Methods of treating or preventing emesis using growth hormone secretagogues

Melt processed crosslinking thermoplastic polyurethane-epoxy mixtures

The compositions of the invention are hot melt urethane compositions for application in the molten state at temperatures of from about 121.1°-232.2 °C having viscosities of less than 50,000 cps which upon cooling form an elastomeric solid.

Improved chromatography column and method of operation

A chromatography column is normally filled with a slurry of media for operation. A piston normally compacts the slurry in the column. The piston moves through a cavity in communication with both a slurry inlet and slurry ports which are in communication with the interior of the chromatography column. A controller receiving inputs from at least one of position sensors and a pressure sensor directs movement of the plunger in an operational step selected from the group of a selected movement and up to a selected pressure.

Folding bale case extension for balers

Methods of treating or preventing emesis using growth hormone secretagogues

Mounting and drive for a horizontally and vertically swingable unloading feed conveyor

A feed-unloading mechanism from a mixing and storage tank comprises a vertically inclined lift auger conveyor receiving feed from a mixing and storage tank and having a discharge head directing the upwardly conveyed feed downwardly through a pivotally mounted chute. The chute directs the feed into a generally horizontal unloading auger conveyor pivotally mounted to swing horizontally and vertically through wide arcs while the unloading feed auger is driven by a bevel gear drive comprising two small bevel gears and a larger intermediate bevel drive gear.

Bi-directional cooling arrangement for use with an electronic component enclosure

A processor book includes a processor card having front and rear surfaces, and at least one high heat component attached to the front surface. Two separate flows of cooling gas are conveyed to the processor card from two separate directions. A cooling duct is provided adjacent to the front surface of the processor card, and conveys one of the flows of cooling gas. The cooling duct has an outlet in a region of the high heat component.

Substituted phenylsulfonamide inhibitors of beta amyloid production

Compounds of Formula I, wherein R 1 -R 8 are defined herein are provided, together with pharmaceutically acceptable salts, hydrates, metabolites, and/or prodrugs thereof. Uses of these compounds for inhibiting beta amyloid production and for the prevention and treatment of Alzheimer’s Disease and Down’s syndrome are described.

Adjustable clamp for conductors

An improved conductor clamp adapted to securely clamp conductors having various sized diameters. The clamp includes a first pair of generally rectangular bar clamping members movable in a first direction toward each other and in an opposite direction away from each other. Each of the first pair of clamping members has one or two generally V-shaped grooves extending the length of the member with a contact area extending therefrom or therebetween. A third clamping member and possibly a fourth clamping member are positioned intermediate the first pair of clamping members. The third and fourth clamping members each include a tail portion and a heal portion having a conductor contact portion. The third and fourth clamping members are positioned and the head portions are configured to be received within the generally V-shaped grooves of the first pair of clamping members such that movement of said first pair of clamping members past a predetermined point toward each other results in the perpendicular directional movement of the third and, if utilized, fourth clamping members toward the contact areas to readily accommodate and secure conductors of various sizes.

Aryl sulfamide derivatives and methods of their use

The present invention is directed to aryl sulfamide derivatives of formula (I): or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.

Hot-melt adhesive compositions

The compositions include a polyurethane composition component and at least one peptizing agent. The polyurethane component includes a mixture of at least one polyisocyanate, one or more hydroxyl terminated polyol, one or more chain extender, and one or more plasticizer. The peptizing agent reduces the viscosity of the polyurethane hot-melt adhesive composition for use in automated, high-volume operations.

Fence structure

ABSTRACT OF THE DISCLOSURE A board-type fence is provided which is of a substantially identical appearance on both sides and which eliminates the need for nails in the construction thereof. The fence comprises a plurality of fence sections having end posts with a plurality of slats or picket members interposed therebetween and secured together by means of elon-gated rod members extending between the posts and transversely through the intermediate slats. Each fence section is secured to adjacent fence sections in side by side, or end to end relation to provide a fence structure of the desired length without the use of nails for holding the fence elements in place.

Flip FERAM cell and method to form same

A method of forming an integrated ferroelectric/CMOS structure which effectively separates incompatible high temperature deposition and annealing processes is provided. The method of the present invention includes separately forming a CMOS structure and a ferroelectric delivery wafer. These separate structures are then brought into contact with each and the ferroelectric film of the delivery wafer is bonded to the upper conductive electrode layer of the CMOS structure by using a low temperature anneal step. A portion of the delivery wafer is then removed providing an integrated FE/CMOS structure wherein the ferroelectric capacitor is formed on top of the CMOS structure. The capacitor is in contact with the transistor of the CMOS structure through all the wiring levels of the CMOS structure.

Melt processed crosslinking thermoplastic polyurethane-epoxy mixtures

Wheeled chair with dual pivots

Method of stimulating the motility of the gastrointestinal system using ipamorelin

Pneumatic conveyor

Polymer viscosity depressant/super cooling thermoplastic urethane

The present invention is directed to multi-component compositions comprising from about 5 % to about 95 % a polyurethane formed by heating a reaction mixture comprising at least one isocyanate having a functionality less than about 2, at least one long chain polyol, at least one chain extender, and at least one plasticizer, or a thermoplastic polymer alloy comprising the reaction product of at least one polyisocyanate having a functionality of 2.2 or less, at least one substantially linear polyhydroxyl compound and/or at least one chain extender, and at least one epoxy resin, or a combination thereof, and at least another thermoplastic material selected from the group consisting of polyamide, polyurethane, ethyl vinyl acetate, polyurethane ester and polyvinyl chloride.