08-03-2018 дата публикации
Номер: US20180064665A1
The present invention relates to a N-phenyl-N′-phenoxycarbonyl-phenylsulfonhydrazide derivative with excellent inhibitory activity on PGEproduction, a method for preparing the same and a pharmaceutical composition comprising the same as an active ingredient. The present N-phenyl-N′-phenoxycarbonyl-phenylsulfonhydrazide derivative may be used effectively for preventing or treating inflammation, arthritis, high fever, pain, cancer, stroke or bone disease. 2. The N-phenyl-N′-phenoxycarbonyl-phenylsulfonhydrazide derivative according to or pharmaceutically acceptable salt thereof claim 1 ,wherein,{'sup': '1', 'sub': 1', '6, 'Ris hydrogen or C-Calkyl,'}{'sup': '2', 'sub': 1', '6', '1', '6', '1', '6, 'Ris C-Calkyl, C-Calkoxy, halogen, C-Chaloalkyl or aryl,'}{'sup': '3', 'sub': 1', '6, 'Ris hydrogen or C-Calkyl,'}{'sup': '4', 'sub': 1', '6, 'Ris hydrogen or C-Calkoxy,'}{'sup': '5', 'Ris hydrogen, and'}{'sup': '6', 'sub': 1', '6', '1', '6, 'Ris hydrogen, C-Calkyl, C-Calkoxy or aryloxy, or'}{'sup': 5', '6, 'Rand Rare taken together with the carbon atom to which they are attached to form a 4 to 7-membered hydrocarbon ring.'}3. The N-phenyl-N′-phenoxycarbonyl-phenylsulfonhydrazide derivative according to or pharmaceutically acceptable salt thereof claim 1 ,wherein,{'sup': '1', 'Ris hydrogen or methyl,'}{'sup': '2', 'Ris methyl, n-propyl, i-propyl, t-butyl, methoxy, chloro, trifluoromethyl or phenyl,'}{'sup': '3', 'Ris hydrogen or methyl,'}{'sup': '4', 'Ris hydrogen or methoxy,'}{'sup': '5', 'Ris hydrogen, and'}{'sup': '6', 'Ris hydrogen, methyl, ethyl, methoxy, ethoxy, phenoxy or benzyloxy, or'}{'sup': 5', '6, 'Rand Rare taken together with the carbon atom to which they are attached to form a 5-membered hydrocarbon ring.'}4. The N-phenyl-N′-phenoxycarbonyl-phenylsulfonhydrazide derivative according to or pharmaceutically acceptable salt thereof selected from the group consisting of the following compounds:N-phenyl-N′-(4-methoxyphenoxycarbonyl)-4-methoxyphenylsulfonhydrazide (I ...
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