24-09-2010 дата публикации
Номер: FR2943341A1
Substituted indazole compounds (I) and their tautomers and racemic isomers, enantiomers, diastereoisomers, addition salts with mineral and organic acids or bases, or prodrugs, are new. Substituted indazole compounds of formula (I) and their tautomers and racemic isomers, enantiomers, diastereoisomers, addition salts with mineral and organic acids or bases, or prodrugs, are new. R 4>H, CH 3, CH 2CH 3, CF 3, Cl or Br; Het : dihydro or tetrahydro-mono or bicyclic 5-11 membered aromatic or partially unsaturated heterocycle containing 1-4 heteroatoms of N, O or S, optionally substituted by one or more R 1>or R1a groups; R : heterocyclic group of formula (A)-(D), or 2H-isoquinolin-1-one-6-yl; R 1>, R1a : H, halo, CF 3, nitro, CN, alkyl, hydroxy, mercapto, amino, alkylamino, dialkylamino, alkoxy, phenyl, alkylthio, free carboxy or esterified by alkyl, carboxamide, CO-NH(alkyl), CON(alkyl) 2, NH-CO-alkyl, sulfonamide, NH-SO 2-alkyl, S(O) 2-NHalkyl, S(O 2)-N(alkyl) 2, where the alkyl, alkoxy and alkylthio are optionally substituted by one or more halo, OH, alkoxy, amino, alkylamino or dialkylamino; W 1>-W 3>CH or N; X : O, S, NR 2>, C(O), S(O) or S(O) 2; V 1>H, halo, -O-R 2>or -NH-R 2>; and R 2>1-6C alkyl, 3-8C cycloalkyl, mono- or bicyclic 3-10C heterocycloalkyl (all optionally substituted by one or more O-PO 3H 2, PO 3Na 2, -O-SO 3H 2, -O-SO 3Na 2, -O-CH 2-PO 3H 2, -O-CH 2-PO 3Na 2, O-CO-alanine, O-CO-glycine, O-CO-serine, O-CO-lysine, O-CO-arginine, O-CO-glycine-lysine, -O-CO-alanine lysine, halo, hydroxy, mercapto, amino, carboxamide, carboxy, heterocycloalkyl, cycloalkyl, heteroaryl, carboxy esterified alkyl, CO-NH(alkyl), -CO-O-alkyl, -NH-CO-alkyl, alkyl, alkoxy, alkylthio, alkylamino, dialkylamino, where the alkyl, alkoxy and alkylthio are optionally substituted by one or more hydroxy, mercapto, amino, alkylamino, dialkylamino, CO 2alkyl, NHCO 2alkyl or heterocycloalkyl (where the cycloalkyl, heterocycloalkyl and heteroaryl are optionally ...
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