SYSTEM AND METHOD FOR GRAPHICALLY BUILDING WEIGHTED SEARCH QUERIES

A system and method allow a user to define a search request by selecting and weighting graphical icons provided on a search creation interface. The graphical icons may be selected by using an icon selection feature provided on the search creation interface. The graphical icons may further be assigned relative search weights using an icon weighting feature provided on the search creation interface. The system and method generate search results based on metadata associated with the selected ones of the graphical icons and the search weights assigned to each of the selected ones of the graphical icons. The search results may comprise a ranked list of items, such as products listed for sale on an e-commerce server. 1. A method of performing an electronic search of a database and generating a combined ranked item list , the method comprising:associating metadata with each of a set of graphical icons in a database;processing user input to define at least two selected ones of the graphical icons from the set of graphical icons;processing user input to define a search weighting preference for each of the at least two selected ones of the graphical icons;processing the at least two selected ones of the graphical icons to generate a ranked item list for each of the at least two selected ones of the graphical icons based on the metadata, wherein the ranked item lists each comprise: items having an associated numerical ranking relative to other items in the ranked item list,wherein the metadata include seed products associated with corresponding graphical icons, andwherein the seed products are weighted, using keywords, and combined into a single ranked list for each corresponding graphical icon, wherein the single ranked list is also used to generate the ranked item list;processing the search weighting preferences and the ranked item lists for the at least two selected ones of the graphical icons to generate a weighted ranked item list for each of the at least two selected ...

Systems and methods of applying compositions to webs

A method of printing composition(s) on a web is disclosed. The method includes the steps of advancing the web and printing a plurality of composition sites on the web. The method further includes the step of forming one or more discontinuities in the web. The discontinuities correspond to the printed composition sites.

Multi-layer dry paint decorative laminate having discoloration prevention barrier

A decorative dry paint wall film includes a layer of dry paint, a pressure-sensitive adhesive layer on one side of the dry paint layer, and a release liner in releasable contact with the dry paint layer on a side opposite from the pressure-sensitive adhesive (PSA). The release liner has a matte release coat layer that contacts the dry paint layer. The release liner is released from the dry paint layer after the PSA side is attached to a wall. The matte release coat transfers a matte finish to the dry paint layer when the release liner is removed. The wall film includes a barrier layer to protect against significant discoloration of the color in the dry paint layer caused by migration of azo-type pigments from a painted wall surface. The barrier layer in one embodiment comprises a dry emulsion containing ethylene-vinyl alcohol and a dispersed polymeric material which in one embodiment comprises a urethane material.

Systems and methods of applying compositions to webs

A method of printing composition(s) on a web is disclosed. The method includes the steps of advancing the web and printing a plurality of composition sites on the web. The method further includes the step of forming one or more discontinuities in the web. The discontinuities correspond to the printed composition sites.

Systems and methods of applying compositions to webs

A method of printing composition(s) on a web is disclosed. The method includes the steps of advancing the web and printing a plurality of composition sites on the web. The method further includes the step of forming one or more discontinuities in the web. The discontinuities correspond to the printed composition sites.

Multi-layer dry paint decorative laminate having discoloration prevention barrier

A decorative dry paint wall film includes a layer of dry paint, a pressure-sensitive adhesive layer on one side of the dry paint layer, and a release liner in releasable contact with the dry paint layer on a side opposite from the pressure-sensitive adhesive (PSA). The release liner has a matte release coat layer that contacts the dry paint layer. The release liner is released from the dry paint layer after the PSA side is attached to a wall. The matte release coat transfers a matte finish to the dry paint layer when the release liner is removed. The wall film includes a barrier layer to protect against significant discoloration of the color in the dry paint layer caused by migration of azo-type pigments from a painted wall surface. The barrier layer in one embodiment comprises a dry emulsion containing ethylene-vinyl alcohol and a dispersed polymeric material which in one embodiment comprises a urethane material.

Systems and Methods Of Applying Compositions To Webs

A method of printing composition(s) on a web is disclosed. The method includes the steps of advancing the web and printing a plurality of composition sites on the web. The method further includes the step of forming one or more discontinuities in the web. The discontinuities correspond to the printed composition sites.

FOOTWEAR WITH PERFORMANCE MEASUREMENT DEVICE

Footwear for an individual such as a cyclist is provided with a performance measurement device for measuring the individual's performance. A first exemplary article of such footwear includes a shoe in combination with an optional means for substantially immobilizing the shoe to a pedal of a cycle, e.g., a cleat, and the performance measurement device. A second exemplary article of such footwear is a sock in combination with the measurement device. Typically, the measurement device is embedded or located within the footwear and is not mounted to an exterior surface, e.g., the bottom sole surface, of the footwear. 1. An article of footwear for a cyclist , comprising ,an upper portion;a sole portion, in combination with the upper portion, forming a shoe having an interior region in which the cyclist's foot may be placed;an optional means for substantially immobilizing the shoe to a pedal of a cycle; anda measurement device associated with the shoe for measuring the cyclist's performance, wherein the measurement device is neither embedded in the immobilizing means nor mounted to a bottom exterior surface of the footwear.2. The article of claim 1 , comprising the immobilizing means.3. The article of claim 2 , wherein the immobilizing means comprises a cleat for engagingly interlocking with the pedals of the cycle claim 2 , the cleat immobilized to the bottom surface of the shoe.4. The article of claim 2 , wherein the immobilizing means comprises a top clip and/or strap substantially immobilized to the pedals of the cycle.5. The article of claim 1 , wherein the measurement device is effective to generate data used to determine metrics selected from cycle cadence claim 1 , uphill speed claim 1 , downhill speed claim 1 , forward speed and backward speed6. The article of claim 1 , wherein the measurement device is located within the interior region of the footwear.7. The article of claim 1 , wherein the sole portion includes a plurality of layers and the measurement device ...

Systems and methods of applying compositions to webs

A method of printing composition(s) on a web is disclosed. The method includes the steps of advancing the web and printing a plurality of composition sites on the web. The method further includes the step of forming one or more discontinuities in the web. The discontinuities correspond to the printed composition sites.

Method for cleaning cookware and tableware with film-forming liquid dishwashing compositions, and compositions therefore

A method for cleaning cookware and tableware with film-forming liquid dishwashing compositions is disclosed. The method includes the steps of applying the composition to soiled cookware/tableware, allowing the composition to form a film and act on the soil, and removing the film with the soil, leaving a clean surface. The compositions include a film-forming polymer, a plasticizer, a cleaning active and a carrier.

Thin film capacitors

A system that incorporates teachings of the present disclosure may include, for example, a first solid electrode, a second electrode separated into subsections, and a dielectric medium separating the subsections from the first solid electrode, where the subsections of the second electrode include a first group of subsections and a second group of subsections, where the first group of subsections are connectable with a first terminal for receiving an input signal, and where the second group of subsections is connectable with a second terminal for providing an output signal. Other embodiments are disclosed.

Benefit agent containing delivery particle

The present invention relates to benefit agent containing delivery particles, compositions comprising said particles, and processes for making and using the aforementioned particles and compositions. When employed in compositions, for example cleaning or fabric care compositions, such particles increase the efficiency of benefit agent delivery, there by allowing reduced amounts of benefit agents to be employed. In addition to allowing the amount of benefit agent to be reduced, such particles allow a broad range of benefit agents to be employed.

System and method for graphically building weighted search queries

A system and method allows a user to define a search request by selecting and weighting graphical icons provided on a search creation interface. The graphical icons may be selected by using an icon selection feature provided on the search creation interface. The graphical icons may further be assigned relative search weights using an icon weighting feature provided on the search creation interface. The system and method generates search results based on metadata associated with the selected ones of the graphical icons and the search weights assigned to each of the selected ones of the graphical icons. The search results may comprise a ranked list of items, such as products listed for sale on an e-commerce server.

Systems And Methods Of Applying Compositions To Webs

A method of printing composition(s) on a web is disclosed. The method includes the steps of advancing the web and printing a plurality of composition sites on the web. The method further includes the step of forming one or more discontinuities in the web. The discontinuities correspond to the printed composition sites.

Systems And Methods Of Applying Compositions To Webs

A method of printing composition(s) on a web is disclosed. The method includes the steps of advancing the web and printing a plurality of composition sites on the web. The method further includes the step of forming one or more discontinuities in the web. The discontinuities correspond to the printed composition sites.

Tunable microwave devices with auto-adjusting matching circuit

An embodiment of the present disclosure provides an impedance matching circuit including a matching network. The matching network includes a first port and a second port, and one or more variable reactance components. The one or more variable reactance components are operable to receive one or more variable voltage signals to cause the one or more variable reactance components to change an impedance of the matching network. At least one of the one or more variable reactance components includes a first conductor coupled to one of the first port or the second port of the matching network, a second conductor, and a tunable material positioned between the first conductor and the second conductor. Additionally, at least one of the first conductor and the second conductor are adapted to receive the one or more variable voltage signals to cause the change in the impedance of the matching network. Additional embodiments are disclosed.

Cohesive emulsion composition comprising a bleaching agent

The present invention relates to a cohesive emulsion comprising a bleaching agent, an emulsifying system, an aqueous phase and an inert hydrophobic phase, wherein the hydrophobic (e.g. oil) phase is in predominant proportion relative to the aqueous phase. In one embodiment the invention relates to a delivery system for delivering a bleaching agent to the teeth surface comprising the present compositions and an integral carrier, e.g. a strip of material. In another embodiment the present invention relates to a method of preparation of emulsions.

Floating Draw Plug and Method of Drawing Tube

A floating draw plug for shaping tube comprises a necking body and a rib forming member. The necking body has an axis and a trailing end portion. The trailing portion has a cross-section that is symmetric about the axis and that converges toward the axis as it extends downstream. The rib forming member comprises helical protrusions and helical grooves. The helical protrusions and the helical grooves are aligned with the axis. The rib forming member is connected to the necking body in a manner such that at least a portion of the helical protrusions and at least a portion of the helical grooves extend downstream of the trailing portion of the necking body and such that the rib forming member is free to rotate about the axis relative to the necking body. 1. A floating draw plug for shaping tube , the draw plug comprising:a necking body, the necking body having an axis and a trailing end portion, the trailing end portion having a cross-section that is symmetric about the axis and that converges toward the axis as it extends downstream; and,a rib forming member, the rib forming member comprising helical protrusions and helical grooves, the helical protrusions and the helical grooves being aligned with the axis, the rib forming member being connected to the necking body in a manner such that at least a portion of the helical protrusions and at least a portion of the helical grooves extend downstream of the trailing portion of the necking body and such that the rib forming member is free to rotate about the axis relative to the necking body.2. A floating draw plug in accordance with wherein the helical protrusions have a constant radius from the axis as they extend downstream.3. A floating draw plug in accordance with wherein the necking body has an axial downstream recess and a portion of rib forming member extends therein.4. A floating draw plug in accordance with wherein the rib forming member is attached to the necking body via a threaded fastener.5. A floating draw ...

Disposable excreta management device

The present invention relates to a disposable excreta management device comprising a composite body adhesive structure for releasable attachment of said device to the body of a wearer, said structure comprising a substrate and a layer of an adhesive material coated onto said substrate. The layer of adhesive material comprises a pattern of less adhesive areas where the adhesive is inactivated or covered by a second material having a lower adhesion on skin compared to said adhesive material. The device is easy to handle, not painful to remove, easy to reposition, and leaves no residues on skin.

Loop crib

Fiber optic distributed vibration sensing with directional sensitivity

Methods for determining separate velocity components of an acoustic wavefield that are incident on a distributed fiber optic sensor are disclosed. A fiber optic sensor includes fiber that is spatially distributed in non-parallel planes of a three-dimensional volume having three orthogonal axes. The fiber includes a first fiber pattern that is spatially distributed within a first plane of the three-dimensional volume, and a second fiber pattern that is spatially distributed within a second plane of the volume. The fiber patterns are interrogated separately by a distributed fiber optic interrogation system. The individual responses from each pattern are combined and processed to determine separate velocity components of the acoustic wavefield relative to the orthogonal axes of the three-dimensional volume.

Fiber optic distributed vibration sensing with wavenumber sensitivity correction

An apparatus and method for correcting the wavenumber sensitivity of a distributed fiber optic sensor are disclosed. The distributed fiber optic sensor is deployed in a region of interest to measure a characteristic of an incident acoustic wavefield. A composite response of the distributed sensor is determined based on backscatter optical signals generated by the sensor, where the composite response is indicative of a characteristic of an incident acoustic wavefield. The composite response includes at least a first response having a first wavenumber sensitivity and a second response having a second wavenumber sensitivity. The second wavenumber sensitivity is selected so that wavenumber notches of the first and second responses do not overlap.

Fishing lure safety cover

Moulding Apparatus and Method

Moulding apparatus comprises a mould (12) defining a blow mould cavity (14) and a core (18) which projects into the blow mould cavity. The mould has at least one mould member (22, 24, 26) movable to an extended position in which it defines together with the core (18) at least part of a preform moulding cavity (28) for moulding a preform. The at least one mould member (22, 24, 26) can be moved to a retracted position [FIG. 2] whereby a preform produced in the preform moulding cavity can be expanded into the blow mould cavity. The moulding apparatus includes a locking member (22) adapted to engage the core so as to resist lateral movement of the core whilst material is introduced into the preform moulding cavity. A method of using the apparatus is also disclosed and claimed.

Systems And Methods Of Applying Compositions To Webs

A method of printing composition(s) on a web is disclosed. The method includes the steps of advancing the web and printing a plurality of composition sites on the web. The method further includes the step of forming one or more discontinuities in the web. The discontinuities correspond to the printed composition sites.

Systems and methods for collecting cutting samples during oil and gas drilling operations

A system for automated collection of cutting samples produced during the drilling of a well includes an automated valve system for periodically collecting samples including fluid and cuttings from a flow line from a drilling rig and a packaging system for packaging each sample collected from the flow line. The packaging system deposits each sample received from the valve system at a corresponding point along a moving elongated strip of base material, covers the elongated strip of base material and samples deposited on the base material with a strip of cover material, and advances the covered elongated strip of base material and covered samples onto a reel.

Tunable microwave devices with auto-adjusting matching circuit

An embodiment of the present disclosure provides a circuit including an antenna having a tunable component. The tunable component can be operable to receive a variable signal to cause the tunable component to change a reactance of the antenna. The tunable component can include a first conductor coupled to the antenna, a second conductor, and a tunable material positioned between the first conductor and the second conductor, where at least one of the first conductor or the second conductor, or both are adapted to receive the variable signal to cause the change in the reactance of the antenna. Additional embodiments are disclosed.

Bluetooth Low Energy for Access Control

A system for accessing a secured area with a device that does not need to be actively operated. The system operates by receiving credential information from a beacon, sending that information as well as its own credential information to a secure server and operating the entrance to the area if the device's credential information to a secure server and operating the entrance to the area if the device's credentials are authorized to operate the mechanism associated with the beacon. 1. A method for operating a mechanical device comprising:receiving a credential signal from a beacon within a receiving device;sending a signal comprised with the devices credentials and the beacon credentials to an authentication server;verifying that the device credentials have access to the mechanical device associated with the beacon credentials; andsending a signal to operate the mechanical device.2. The method for operating a mechanical device of wherein the signal from the beacon comprises a Bluetooth signal.3. The method for operating a mechanical device of wherein the signal to operate the mechanical device is routed through a security protocol before operating the mechanical device.4. The method for operating a mechanical device of wherein the signal from the beacon is a Bluetooth signal.5. The method for operating a mechanical device of wherein the security protocol is a wiegand controller6. The method for operating a mechanical device of wherein the signal from the beacon is a Bluetooth signal.7. The method of wherein the mechanical device is a door.8. The system for operating a mechanical device of wherein the signal from the beacon is a Bluetooth signal.9. The method for operating a door of wherein the signal to operate a mechanical device is sent through a security protocol before operating the mechanical device.10. The method for operating a mechanical device of wherein the signal from the beacon is a Bluetooth signal.11. The method for operating a mechanical device of ...

Ring seal with sealing surface extension

A ring seal for sealing opposing flow component sealing surfaces defines a fluid flow path that is suitable for applications such as a semiconductor manufacturing modular gas delivery system. The ring seal includes an annular extension in the form of a modified “delta” extending from one or both sealing surfaces of the ring seal. The modified “delta” extends to an apex or point above the ring seal's sealing surface. First and second extension surfaces extend in opposite directions from the apex back toward the ring seal's sealing surface. In one aspect, the first extension surface defines a ridge where the slope of the first extension surface changes to decline faster to the ring seal's sealing surface. In another aspect, the apex is located within the annular extension closer to the axial hole than to an outer radial diameter of the annular seal body.

Thin film capacitors

A system that incorporates teachings of the present disclosure may include, for example, a first solid electrode, a second electrode separated into subsections, and a dielectric medium separating the subsections from the first solid electrode, where the subsections of the second electrode include a first group of subsections and a second group of subsections, where the first group of subsections are connectable with a first terminal for receiving an input signal, and where the second group of subsections is connectable with a second terminal for providing an output signal. Other embodiments are disclosed. 1. An apparatus , comprising:a first solid electrode;a second electrode separated into subsections; anda dielectric medium separating the subsections from the first solid electrode,wherein the subsections of the second electrode comprise a first group of subsections and a second group of subsections,wherein the first group of subsections and the first solid electrode form a first group of capacitors,wherein the second group of subsections and the first solid electrode form a second group of capacitors,wherein each capacitor of the first group of capacitors is in parallel,wherein each capacitor of the second group of capacitors is in parallel,wherein the first group of capacitors is in series with the second group of capacitors,wherein the first group of subsections is connectable with a first terminal for receiving an input signal, andwherein the second group of subsections is connectable with a second terminal for providing an output signal.2. The apparatus of claim 1 , wherein at least a portion of the subsections has a cross shape.3. The apparatus of claim 1 , wherein the subsections have a rectangular shape and are parallel to each other claim 1 , and wherein the first and second groups of capacitors are formed in an alternating pattern.4. The apparatus of claim 1 , wherein the first and second terminals have a comb shape with a terminal body and terminal ...

GPCR Agonists

Compounds of formula (I): 2. A compound according to claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein Z is optionally substituted phenyl or 6-membered heteroaryl.3. A compound according to claim 2 , or a pharmaceutically acceptable salt thereof claim 2 , wherein Z is phenyl.4. A compound according to claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein Z is substituted by one or more halo claim 1 , Calkyl claim 1 , Cfluoroalkyl claim 1 , Calkenyl claim 1 , Calkynyl claim 1 , CN claim 1 , S(O)R claim 1 , NRC(O)NRR claim 1 , C(O)NRR claim 1 , SO claim 1 ,NRR claim 1 , COR claim 1 , COORor a 5- or 6-membered heteroaryl groups.5. A compound according to claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein G is N—C(O)OR claim 1 , N—C(O)NRRor N-heteroaryl.6. A compound according to claim 5 , or a pharmaceutically acceptable salt thereof claim 5 , wherein G is N—C(O)OR.7. A compound according to claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein Rrepresents Calkyl claim 1 , Calkenyl or Calkynyl optionally substituted by one or more halo atoms or CN claim 1 , and may contain a CHgroup that may be replaced by O or S; or a Ccycloalkyl claim 1 , aryl or Calkylene Ccycloalkyl claim 1 , any of which may be substituted with one or more substituents selected from halo claim 1 , Calkyl claim 1 , Cfluoroalkyl claim 1 , OR claim 1 , CN claim 1 , NRR claim 1 , NOor C(O)OCalkyl.8. A compound according to claim 7 , or a pharmaceutically acceptable salt thereof claim 7 , wherein Rrepresents Calkyl optionally substituted by one or more halo atoms or CN claim 7 , and which may contain a CHgroup that is replaced by O or S claim 7 , or Ccycloalkyl optionally substituted by Calkyl.9. A compound according to claim 7 , or a pharmaceutically acceptable salt thereof claim 7 , wherein the group represented by Ris unsubstituted.10. A compound according to claim 1 , or a pharmaceutically acceptable salt thereof ...

METHOD AND APPARATUS FOR FIRING A PROJECTILE WITH A MOTIVE GAS

An assembly for selectively exposing a firing chamber to a motive gas is provided by using a solenoid valve to expose selected portions of a tubular sliding valve to a lower pressure control gas. The tubular sliding valve includes a through passage for transfer of the projectile from a breech to the firing chamber. An on board controller can dictate actuation of the solenoid valve in accordance with a remaining pressure of the motive gas and user input. 1. An assembly for selectively exposing a firing chamber to a motive gas to propel a projectile from the firing chamber through a barrel , the assembly comprising:(a) a tubular sliding valve movable between a first position exposing the firing chamber to the motive gas and a second position blocking motive gas from passing to the firing chamber, the tubular sliding valve having a through passage extending from a rear end of the tubular sliding valve to a front end of the tubular sliding valve, the through passage sized to pass the projectile.2. The assembly of claim 1 , further comprising a motive gas reservoir retaining a volume of motive gas.3. The assembly of claim 2 , further comprising a regulator fluidly connected to the motive gas reservoir to produce a volume of lower pressure control gas.4. The assembly of claim 1 , further comprising a bolt having a portion slideably disposed within the through passage to be movable between a firing position disposing the projectile in the firing chamber and a loading position spaced from the firing chamber.5. The assembly of claim 4 , wherein the loading position of the bolt is longitudinally spaced from the tubular sliding valve.6. The assembly of claim 4 , wherein the bolt and the tubular sliding valve at least partially define a balancing chamber claim 4 , the balancing chamber being selectively fluidly connected to the motive gas.7. The assembly of claim 1 , further comprising a piston connected to the tubular sliding valve for movement with the tubular sliding valve ...

POLYMERIC DEFOAMER ADDITIVE

The present invention relates to a cost-effective and environmentally friendly polymeric defoamer formulation for use in various industrial applications that does not contain oil, EBS or free silicone. 1. A defoamer formulation comprising 0.01 to 50% by weight of an acrylate polymer with 1-20 mol % acrylic acid in a suitable diluent , based on a total weight of the formulation , 20-80% by weight of an organic carrier , based on a total weight of the formulation , 0.01 to 15% by weight of an additive , based on a total weight of the formulation , and optionally , 0.01 to 30% by weight of a surfactant , based on a total weight of the formulation.3. The defoamer formulation of claim 2 , wherein the acrylate polymer is a product of a polymerization reaction between 2-ethylhexyl acrylate monomer claim 2 , 2-hydroxyethyl acrylate monomer claim 2 , and acrylic acid monomer.4. The defoamer formulation of claim 1 , comprising 20-30% by weight hydroxyalkyl/alkyl acrylate polymer with 8 mol % acrylic acid monomer claim 1 , based on a total weight of the formulation.5. The defoamer formulation of claim 1 , wherein the suitable diluent is selected from diisodecyl phthalate claim 1 , diisooctyl adipate claim 1 , bis-2-ethylhexyl adipate claim 1 , dioctyl adipate claim 1 , 2-ethyl-1-hexanol claim 1 , isooctyl alcohol claim 1 , dihexyl phthalate claim 1 , or mixtures thereof.6. The defoamer formulation of claim 5 , wherein the suitable diluent is diisoctyl adipate.7. The defoamer formulation of claim 1 , comprising 40-60% by weight of an organic carrier claim 1 , based on a total weight of the formulation.8. The defoamer formulation of claim 1 , wherein the organic carrier is selected from diisodecyl phthalate claim 1 , diisooctyl adipate claim 1 , bis-2-ethylhexyl adipate claim 1 , dioctyl adipate claim 1 , 2-ethyl-1-hexanol claim 1 , isooctyl alcohol claim 1 , dihexyl phthalate claim 1 , polybutenes having a molecular weight of from about 300-1300 atomic mass units claim 1 , ...

DRUG DELIVERY SYSTEM WITH OPEN ARCHITECTURAL FRAMEWORK

A medical system includes a sedation system and a central station in communication with the sedation system. The sedation system includes a monitoring unit and a drug delivery unit. The monitoring unit is operable to monitor at least one physiological parameter of a patient. The drug delivery unit is operable to deliver drugs to the patient based on data from the monitoring unit. The central station is operable to store patient related data and access a plurality of sedation systems. The central station may remotely control drug delivery through sedation systems, remotely provide voice instructions through sedation systems, display video feeds from sedation systems, respond to queries from sedation systems, and/or provide other functionalities. The system may also include an instrument that is operable to perform surgical and/or therapeutic procedures on the patient. The sedation system may provide power to the instrument and/or otherwise communicate with the instrument. 1. A medical system , comprising: (i) a monitoring unit, wherein the monitoring unit is operable to monitor at least one physiological parameter of a patient, and', '(ii) a drug delivery unit, wherein the drug delivery unit is in communication with the monitoring unit, wherein the drug delivery unit is operable to at least partially automate delivery of one or more drugs to the patient based on the at least one physiological parameter of the patient; and, '(a) a sedation system, the sedation system comprising(b) a central station, wherein the central station is in communication with the sedation system, wherein the central station is also in communication with a plurality of other sedation systems, wherein the central station is operable to store patient related data, wherein the central station is further operable to individually access the sedation system and the plurality of other sedation systems.2. The medical system of claim 1 , wherein the central station is configured to process data from ...

USER INTERFACE FEATURE FOR DRUG DELIVERY SYSTEM

A medical system includes a monitoring unit and a drug delivery unit. The monitoring unit is operable to monitor at least one physiological parameter of a patient. The drug delivery unit includes an integral volume of a drug. A control logic is in communication with the monitoring unit and the drug delivery unit and is operable to regulate delivery of the drug to the patient from the integral volume, based on data associated with the at least one physiological parameter of the patient, in accordance with a safety shell control algorithm. A user interface feature is operable to receive input indicating administration of an external drug to the patient. The safety shell control algorithm responds to inputs received through the user interface feature indicating administration of an external drug to the patient, such as by modifying subsequent drug delivery regulation based on the administration of the external drug. 1. A medical system , comprising:(a) a monitoring unit, wherein the monitoring unit is operable to monitor at least one physiological parameter of a patient;(b) a drug delivery unit, wherein the drug delivery unit is in communication with the monitoring unit, wherein the drug delivery unit includes at least one integral volume of one or more drugs;(c) a control logic configured to execute a safety shell control algorithm, wherein the control logic is in communication with the monitoring unit and the drug delivery unit, wherein the drug delivery unit is operable to regulate delivery of at least one of the one or more drugs to the patient from the integral volume based on data associated with the at least one physiological parameter of the patient in accordance with the safety shell control algorithm; and(d) a user interface feature in communication with the control logic, wherein the user interface feature is operable to receive input indicating administration of an external drug to the patient, wherein the safety shell control algorithm is configured to ...

DRUG DELIVERY SYSTEM WITH PROCEDURE STAGE BASED DELIVERY ADJUSTMENT

A medical system includes a monitoring unit and a drug delivery unit. The monitoring unit is operable to monitor at least one physiological parameter of a patient. The drug delivery unit includes an integral volume of a drug. A control logic is in communication with the monitoring unit and is operable to regulate delivery of the drug to the patient from the integral volume, based on data associated with the at least one physiological parameter of the patient, in accordance with a safety shell control algorithm. A user interface feature is operable to receive input indicating a stage of progress in a medical procedure. The safety shell control algorithm responds to inputs received through the user interface feature indicating a stage of progress in a medical procedure, such as by modifying subsequent drug delivery regulation based on the beginning or completion of a stage of progress in a medical procedure. 1. A medical system , comprising:(a) a monitoring unit, wherein the monitoring unit is operable to monitor at least one physiological parameter of a patient;(b) a drug delivery unit, wherein the drug delivery unit is in communication with the monitoring unit, wherein the drug delivery unit includes an integral volume of one or more drugs;(c) a control logic configured to execute a safety shell control algorithm, wherein the control logic is in communication with the monitoring unit and the drug delivery unit, wherein the drug delivery unit is operable to regulate delivery of at least one of the one or more drugs to the patient from the integral volume based on data associated with the at least one physiological parameter of the patient in accordance with the safety shell control algorithm; and(d) a user interface feature in communication with the control logic, wherein the user interface feature is operable to receive input indicating a stage of progress in a medical procedure, wherein the safety shell control algorithm is configured to respond to inputs received ...

Tunable Microwave Devices with Auto-Adjusting Matching Circuit

An embodiment of the present disclosure provides an impedance matching circuit including a matching network. The matching network includes a first port and a second port, and one or more variable reactance components. The one or more variable reactance components are operable to receive one or more variable voltage signals to cause the one or more variable reactance components to change an impedance of the matching network. At least one of the one or more variable reactance components includes a first conductor coupled to one of the first port or the second port of the matching network, a second conductor, and a tunable material positioned between the first conductor and the second conductor. Additionally, at least one of the first conductor and the second conductor are adapted to receive the one or more variable voltage signals to cause the change in the impedance of the matching network. Additional embodiments are disclosed. 1. An impedance matching circuit , comprising:a matching network to couple to a variable load;wherein the matching network comprises a first port and a second port;wherein the variable load is coupled to one of the first port or the second port;wherein the matching network comprises one or more variable dielectric capacitors;wherein the one or more variable dielectric capacitors are operable to receive one or more variable voltage signals to cause the one or more variable dielectric capacitors to change an impedance of the matching network; a first conductor coupled to one of the first port or the second port;', 'a second conductor; and', 'a tunable dielectric material positioned between the first conductor and the second conductor, wherein at least one of the first conductor or the second conductor, or both are adapted to receive the one of the one or more variable voltage signals to cause the change in the impedance of the matching network., 'wherein at least one of the one or more variable dielectric capacitors comprises2. The impedance ...

CAPACITORS ADAPTED FOR ACOUSTIC RESONANCE CANCELLATION

An embodiment of a tunable capacitor can include a plurality of capacitors connected in series where at least two capacitors of the plurality of capacitors share a common electrode where the at least two capacitors are in lateral proximity and a bias that is capable of being applied to the at least two capacitors whereby the at least two capacitors vibrate in opposite phase to each other when the bias and an RF signal is applied to the at least two capacitors. 1. A system comprising:a matching network including a plurality of capacitors, wherein the plurality of capacitors is an even number of voltage tunable capacitors positioned in proximity to each other, and wherein pairs of the voltage tunable capacitors share one common electrode; anda bias element coupled with the matching network, wherein the bias element applies a bias to the plurality of capacitors such that the plurality of capacitors vibrate in opposite phase to each other when the bias and an RF signal is applied to the plurality of capacitors.2. The system of claim 1 , wherein the bias is a DC bias claim 1 , and wherein the voltage tunable capacitors comprise a dielectric material including barium strontium titanate.3. The system of claim 1 , wherein the plurality of capacitors is formed by a multi-layered dielectric structure.4. The system of claim 1 , wherein the plurality of capacitors comprises:a first electrode and a second electrode that are positioned in lateral proximity to each other;a third electrode positioned opposite to the first and second electrodes;a tunable dielectric layer positioned between the third electrode and the first and second electrodes to form first and second tunable capacitors that share the third electrode as the one common electrode and that are acoustically coupled together.5. The system of claim 4 , wherein the bias element applies the bias from the first electrode to the third electrode and then to the second electrode.6. The system of claim 4 , wherein the first and ...

Tunable Microwave Devices with Auto-Adjusting Matching Circuit

An embodiment of the present disclosure provides a variable impedance circuit including an antenna having a tunable component. The tunable component can be operable to receive a variable signal to cause the tunable component to change an impedance of the antenna. The tunable component can include a first conductor coupled to the antenna, a second conductor, and a tunable material positioned between the first conductor and the second conductor, where at least one of the first conductor or the second conductor, or both are adapted to receive the variable signal to cause the change in the impedance of the antenna. Additional embodiments are disclosed. 1. A variable impedance circuit , comprising:a matching network to couple to a tunable device;wherein the matching network comprises a first port and a second port;wherein the tunable device is coupled to one of the first port or the second port;wherein the matching network comprises one or more variable dielectric capacitors;wherein the one or more variable dielectric capacitors are operable to receive a first of one or more variable voltage signals to cause the one or more variable dielectric capacitors to change a first impedance of the matching network;wherein the tunable device is operable to receive a second of one or more variable voltage signals to cause a change in a second impedance of the tunable device; and a first conductor coupled to one of the first port or the second port;', 'a second conductor; and', 'a tunable dielectric material positioned between the first conductor and the second conductor, wherein at least one of the first conductor or the second conductor, or both are adapted to receive the first of the one or more variable voltage signals to cause the change in the first impedance of the matching network., 'wherein at least one of the one or more variable dielectric capacitors comprises2. The variable impedance circuit of claim 1 , wherein the change in the first impedance of the matching network ...

ROTOR RETRIEVAL TOOL

A tool is presented that assists in the assembly, disassembly, maintenance and retrieval of elements of a hydrodynamic array, such as a drive train. The tool can function like a clamp in facilitating the removal of a turbine assembly from a nested machinery chamber or caisson module with the use of an overhead gantry crane. 1. A tool for securing elements of a hydrodynamic array , comprising:a first jaw having a first collar with bars extending from the first collar; anda second jaw having a second collar with bars extending from the second collar, the first jaw and the second jaw being configured to be brought together as two opposable parts whose ends terminate in a hinge joint for permitting motion in one plane.2. The tool of claim 1 , wherein the first jaw and the second jaw finish in a cylindrical-shaped chamber with thickened walls occupying a portion of the width of a bar of the first jaw while the remaining portion is a thin curved wall extending from the cylindrical-shaped chamber which flushes with the edge of the bar claim 1 , when the first jaw and the second jaw are brought together claim 1 , each opposing cylindrical-shaped chamber is embraced by the other's thinner curved wall to cause each opposing cylindrical-shaped chamber to be coaxially aligned.3. The tool of claim 1 , wherein the first jaw and the second jaw finish in a comb-shaped structure claim 1 , each tool of the comb-shaped structure being polygonal in shape claim 1 , when the first jaw and the second jaw are brought together claim 1 , the teeth of the comb-shaped structures interlock to create the hinge joint.4. The tool of claim 3 , wherein each tooth of the comb-shaped structure is a polygon that houses at least one aperture claim 3 , each aperture being coaxially aligned with other apertures of other teeth.5. The tool of claim 1 , wherein each bar of the first and second jaw has a set of apertures for receiving ring-shaped head bolts to secure the first and second jaw together.6. The ...

Capacitors Adapted for Acoustic Resonance Cancellation

An embodiment of the present invention provides a method, comprising reducing the losses due to electro-mechanical coupling and improving Q in a multilayered capacitor by placing a first capacitor layer adjacent at least one additional capacitor layer and sharing a common electrode in between the two such that the acoustic vibration of the first layer is coupled to an anti-phase acoustic vibration of the at least one additional layer. 1. A device comprising:a matching network including first and second voltage tunable capacitors that share a common electrode; anda bias element coupled with the matching network, wherein the bias element applies a first bias voltage to the first voltage tunable capacitor, wherein the bias element applies a second bias voltage to the second voltage tunable capacitor, and wherein the applying of the first and second bias voltages causes the first and second voltage tunable capacitors to vibrate in opposite phase to each other.2. The device of claim 1 , wherein the first and second voltage tunable capacitors comprise a dielectric material including barium strontium titanate.3. The device of claim 2 , wherein the first and second voltage tunable capacitors are a multi-layered stacked dielectric structure including multiple layers of the dielectric material.4. The device of claim 1 , wherein the first and second voltage tunable capacitors comprise:a first electrode and a second electrode that are positioned in lateral proximity to each other, wherein the common electrode is positioned opposite to the first and second electrodes; anda single tunable dielectric layer positioned between the common electrode and the first and second electrodes to form the first and second voltage tunable capacitors that are acoustically coupled together.5. The device of claim 4 , wherein the bias element applies the bias from the first electrode to the common electrode and then to the second electrode.6. The device of claim 4 , wherein the first and second ...

HIPPO AND DYSTROPHIN COMPLEX SIGNALING IN CARDIOMYOCYTE RENEWAL

Embodiments of the disclosure include methods and compositions for the renewal of cardiomyocytes by targeting the Hippo pathway. In particular embodiments, an individual with a need for cardiomyocyte renewal is provided an effective amount of a shRNA molecule that targets the Sav1 gene. Particular shRNA sequences are disclosed. 1. An isolated synthetic nucleic acid composition , comprising SEQ ID NO:11 and/or a derivative nucleic acid comprising at least 80% identity to SEQ ID NO:11 , wherein the composition further comprises an antisense sequence of SEQ ID NO:11 , wherein when the sequence and the antisense sequence are hybridized together to form a duplex structure , the sequence and the antisense sequence are separated by a loop structure.2. The composition of claim 1 , wherein the derivative nucleic acid is at least 85% claim 1 , 90% claim 1 , 95% claim 1 , 96% claim 1 , 97% claim 1 , 98% claim 1 , or 99% identical to SEQ ID NO:11.3. The composition of claim 1 , wherein said nucleic acid is at least 43 nucleotides in length.4. The composition of claim 1 , wherein said nucleic acid is no more than 137 nucleotides in length.5. The composition of claim 1 , wherein the loop structure is between 5 and 19 nucleotides in length.6. The composition of claim 1 , wherein the derivative nucleic acid has 1 claim 1 , 2 claim 1 , 3 claim 1 , 4 claim 1 , or 5 mismatches compared to SEQ ID NO:11.7. The composition of claim 1 , wherein the nucleic acid or derivative nucleic acid is comprised in a vector.8. The composition of claim 7 , wherein the vector is a viral vector.9. The composition of claim 7 , wherein the vector is a non-viral vector.10. The composition of claim 7 , wherein the vector is a non-integrating vector.11. The composition of claim 10 , wherein the non-integrating vector is a lentiviral vector.12. The composition of claim 7 , wherein the expression of the nucleic acid is regulated by a tissue-specific or cell-specific promoter.13. The composition of claim 12 , ...

THIN FILM CAPACITORS

A system that incorporates teachings of the present disclosure may include, for example, a first solid electrode, a second electrode separated into subsections, and a dielectric medium separating the subsections from the first solid electrode, where the subsections of the second electrode include a first group of subsections and a second group of subsections, where the first group of subsections are connectable with a first terminal for receiving an input signal, and where the second group of subsections is connectable with a second terminal for providing an output signal. Other embodiments are disclosed. 1. An apparatus , comprising:a top electrode;a bottom electrode; anda dielectric medium separating the top electrode from the bottom electrode,wherein the top electrode comprise a first segmented electrode and a second segmented electrode,wherein the first segmented electrode and the bottom electrode form a first group of capacitors,wherein the second segmented electrode and the bottom electrode form a second group of capacitors,wherein each capacitor of the first group of capacitors is arranged in parallel,wherein each capacitor of the second group of capacitors is arranged in parallel,wherein the first group of capacitors is in series with the second group of capacitors, andwherein electrodes of the first segmented electrode and the second segmented electrode are arranged in a nested array configuration.2. The apparatus of claim 1 , wherein electrodes of the first segmented electrode and the second segmented electrode have a cross shape.3. The apparatus of claim 1 , wherein electrodes of the first segmented electrode and the second segmented electrode have a rectangular shape and are parallel to each other claim 1 , and wherein the first group of capacitors and the second groups of capacitors are formed in an alternating pattern.4. The apparatus of claim 1 , wherein the first segmented electrode is connectable with a first terminal for receiving an input signal ...

DOMINANT ACTIVE YAP, A HIPPO EFFECTOR, INDUCES CHROMATIN ACCESSIBILITY AND CARDIOMYOCYTE RENEWAL

The present disclosure encompasses methods for generating cells or tissue from existing cells with one or more mutated variants of Yap. In specific embodiments, the disclosure regards treatment of existing cardiomyocytes with one or more mutated variants of Yap that causes them to divide and generate new cardiomyocytes. In specific cases, the mutated variant of Yap has serine-to-alanine substitutions at 1, 2, 3, 4, 5, 6, or more serines of Yap. 1. A method of regenerating cells in an individual , comprising the step of providing to the individual a therapeutically effective amount of a mutated variant of Yap.2. The method of claim 1 , wherein the cells that are regenerated are cardiomyocytes claim 1 , retinal cells claim 1 , or hair cells of the ear.3. The method of claim 1 , wherein the mutated variant comprises one or more amino acid substitutions at a serine.4. The method of claim 1 , wherein there are 2 claim 1 , 3 claim 1 , 4 claim 1 , 5 claim 1 , 6 claim 1 , 7 claim 1 , or more amino acid substitutions at a serine.5. The method of claim 1 , wherein there are 1 claim 1 , 2 claim 1 , 3 claim 1 , 4 claim 1 , or 5 amino acid substitutions at serines that are phosphorylated by Lats kinases.6. The method of claim 1 , wherein one or more amino acid substitutions are to an alanine.7. The method of claim 1 , wherein the mutated variant of Yap comprises a K265R mutation.8. The method of claim 1 , wherein the individual has a cardiac condition claim 1 , a retinal condition claim 1 , or an otological condition.9. The method of claim 8 , wherein the cardiac condition in the individual causes the individual to be in need of cardiomyocyte renewal.10. The method of claim 8 , wherein the heart of the individual has cardiomyocyte apoptosis claim 8 , necrosis claim 8 , and/or autophagy.11. The method of claim 8 , wherein the cardiac condition is a cardiac condition selected from the group consisting of heart disease claim 8 , cardiomyopathy claim 8 , heart valve problems claim 8 ...

Capacitors Adapted for Acoustic Resonance Cancellation

An embodiment of the present invention provides a method, comprising reducing the losses due to electro-mechanical coupling and improving Q in a multilayered capacitor by placing a first capacitor layer adjacent at least one additional capacitor layer and sharing a common electrode in between the two such that the acoustic vibration of the first layer is coupled to an anti-phase acoustic vibration of the at least one additional layer. 1. A device comprising:a matching network including first and second voltage tunable capacitors, wherein the first voltage tunable capacitor has a first electrode, wherein the second voltage tunable capacitor has a second electrode, wherein the first and second electrodes are positioned in proximity to each other, and wherein the first and second voltage tunable capacitors share a common electrode; anda bias element coupled with the matching network, wherein the bias element applies a bias voltage to the first electrode of the first voltage tunable capacitor and to the second electrode of the second voltage tunable capacitor causing the first and second voltage tunable capacitors to vibrate in opposite phase to each other substantially cancelling first and second electro-mechanical vibrations generated by the first and second voltage tunable capacitors, andwherein the common electrode is unbiased.2. The device of claim 1 , wherein the common electrode is positioned opposite to the first and second electrodes.3. The device of claim 1 , wherein the first and second voltage tunable capacitors comprise a single tunable dielectric layer positioned between the common electrode and the first and second electrodes.4. The device of claim 3 , wherein the first and second electrodes are positioned along an outer surface of the single tunable dielectric layer.5. The device of claim 3 , wherein the single tunable dielectric layer comprises barium strontium titanate.6. The device of claim 1 , wherein the first and second voltage tunable capacitors ...

Novel compounds and pharmaceutical compositions thereof for the treatment of cystic fibrosis

The present invention discloses compounds according to Formula I: wherein R 1 is as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment cystic fibrosis by administering a compound of the invention.

AQUEOUS COPOLYMER DISPERSIONS AND THEIR USE IN COATING COMPOSITIONS

An aqueous copolymer dispersion is obtained by a multi-stage emulsion polymerization process comprising polymerizing in a reaction zone in a first polymerization stage a first monomer composition comprising at least 88 wt % of a vinyl ester of a Cto Ccarboxylic acid and up to 12 wt % ethylene to produce a first stage polymer having Tg>20° C.; and polymerizing in the reaction zone, in a second polymerization stage and in the presence of the first stage polymer, a second monomer composition comprising a vinyl ester of a Cto Ccarboxylic acid and a Cto Calkyl ester of (meth)acrylic acid to produce a second stage polymer having Tg≤20° C. Each of the polymerization stages is conducted in the presence of a stabilizing system comprising at least 0.1 wt % of a protective colloid and at least 0.05 wt % of an ionic surfactant. 1. An aqueous copolymer dispersion obtained by a free radical-initiated multi-stage emulsion polymerization process comprising:{'sub': 1', '18, '(a) polymerizing in a reaction zone in a first polymerization stage a first monomer composition comprising at least 88 weight percent of at least one vinyl ester of a Cto Ccarboxylic acid and up to 12 weight percent ethylene to produce a first stage polymer having a glass transition temperature Tg of greater than 20° C.; and'}{'sub': 1', '18', '2', '8, '(b) polymerizing in the reaction zone, in a second polymerization stage and in the presence of the first stage polymer, a second, different monomer composition comprising at least one vinyl ester of a Cto Ccarboxylic acid and at least one Cto Calkyl ester of acrylic or methacrylic acid in an amount up to 30 weight percent of the total monomers in the second monomer composition to produce a second stage polymer having a glass transition temperature Tg of less than or equal to 20° C.,'}{'sub': 2', '8, 'wherein the first monomer composition is substantially free of Cto Calkyl esters of acrylic or methacrylic acid;'}wherein the second monomer composition is metered ...

TUNABLE MICROWAVE DEVICES WITH AUTO-ADJUSTING MATCHING CIRCUIT

An embodiment of the present disclosure provides a circuit including an antenna having a tunable component. The tunable component can be operable to receive a variable signal to cause the tunable component to change a reactance of the antenna. The tunable component can include a first conductor coupled to the antenna, a second conductor, and a tunable material positioned between the first conductor and the second conductor, where at least one of the first conductor or the second conductor, or both are adapted to receive the variable signal to cause the change in the reactance of the antenna. Additional embodiments are disclosed. 1. A variable circuit , comprising:a matching network coupable to a tunable device;wherein the matching network comprises a first port and a second port;wherein the tunable device is coupled to one of the first port or the second port;wherein the matching network comprises one or more variable capacitors;wherein the one or more variable capacitors are operable to receive a first of one or more variable voltage signals to cause the one or more variable capacitors to change a first reactance of the matching network;wherein the tunable device is operable to receive a second of one or more variable voltage signals to cause a change in a second reactance of the tunable device; and a first conductor coupled to one of the first port or the second port;', 'a second conductor; and', 'a tunable material positioned between the first conductor and the second conductor, wherein at least one of the first conductor or the second conductor, or both are adapted to receive the first of the one or more variable voltage signals to cause the change in the first reactance of the matching network., 'wherein at least one of the one or more variable capacitors comprises2. The variable circuit of claim 1 , wherein the change in the first reactance of the matching network causes an increase in power transferred from the first port to the second port or from the second ...

TUNABLE MICROWAVE DEVICES WITH AUTO-ADJUSTING MATCHING CIRCUIT

An embodiment of the present disclosure provides an impedance matching circuit including a matching network. The matching network includes a first port and a second port, and one or more variable reactance components. The one or more variable reactance components are operable to receive one or more variable voltage signals to cause the one or more variable reactance components to change an impedance of the matching network. At least one of the one or more variable reactance components includes a first conductor coupled to one of the first port or the second port of the matching network, a second conductor, and a tunable material positioned between the first conductor and the second conductor. Additionally, at least one of the first conductor and the second conductor are adapted to receive the one or more variable voltage signals to cause the change in the impedance of the matching network. Additional embodiments are disclosed. 1. An apparatus , comprising:a matching network including a tunable reactive element, the matching network being coupled with an antenna of a mobile communication device and positioned between the antenna and a power amplifier of the mobile communication device;a controller coupled with the matching network; anda directional coupler coupled with the controller and positioned between the matching network and the power amplifier,wherein the controller obtains parameters via the directional coupler for forward and reverse signals at a port of the matching network,wherein the controller adjusts the tunable reactive element according to the parameters to perform impedance matching.2. The apparatus of claim 1 , wherein the controller converts signals corresponding to the parameters into digital signals claim 1 , and wherein the controller processes the digital signals using an algorithm to produce compensatory voltages that are provided to the matching network for the adjusting of the tunable reactive element.3. The apparatus of claim 1 , wherein ...

Antimicrobial compounds and/or modulators of microbial infections and methods of using the same

Some embodiments include compounds that can inhibit the growth of bacterial and/or inhibit or reduce microbial infections caused by one or more microorganisms (e.g., Pseudomonas aeruginosa and Cryptococcus neoformans) and methods of using these compounds to treat microbial infection and outbreaks and/or to reduce the formation of biofilms. Other embodiments include synthesis of the compounds that can inhibit the growth of one or more microorganisms and/or inhibit or reduce microbial infections.

Rail System for Thermoformer with Dual Motor Chain Drive

A thermoformer apparatus has sheet supporting rails which are divided into sections hinged together to facilitate widening of the spacing between the rails with adjuster drive mechanism as the sheet moves through an oven to eliminate sagging of the sheet as it becomes heated. Thermoformer chains are driven by a pair of independently operable servo motors each associated with a respective thermoformer chain. 1. In a thermoforming apparatus of a type including a pair of longitudinal rails for supporting sheet material to be thermoformed , said rails extending from an entry end adapted to receive a sheet of plastic to be loaded therein , through an oven adapted to receive said sheet driven thereinto by a sheet drive mechanism included in said thermoforming apparatus to heat the same , through a form station having tooling located therein adapted to form product into said heated sheet , and a discharge/cooling end discharging sheet with product formed therein , the improvement comprising:a series of hinges along each rail connecting a series of end to end sections together forming each of said rails, said sections connected together by said hinges allowing relative pivoting motion of said connected sections of each rail.2. The thermoforming apparatus according to wherein a pair of first rail sections are located adjacent said entry end and extending into said oven claim 1 , second rail sections extend from the respective ends of said first rail sections and through said oven claim 1 , with a hinge connecting said first and second rail sections end to end allowing pivoting motion therebetween;a pair of third rail sections extended from the ends of said second rail sections, with a hinge connecting end to end each of said second and third rail sections; and a pair of fourth rail sections extending end to end from said third rail sections with a hinge connecting each of said third and fourth sections end to end.3. The thermoforming apparatus according to further including ...

HIPPO AND DYSTROPHIN COMPLEX SIGNALING IN CARDIOMYOCYTE RENEWAL

Embodiments of the disclosure include methods and compositions for the renewal of cardiomyocytes by targeting the Hippo pathway. In particular embodiments, an individual with a need for cardiomyocyte renewal is provided an effective amount of a shRNA molecule that targets the Sav1 gene. Particular shRNA sequences are disclosed. 1. An isolated synthetic nucleic acid composition , comprising SEQ ID NO: 10 , SEQ ID NO: 11 , or SEQ ID NO: 12 and/or a derivative nucleic acid comprising at least 80% identity to one of SEQ ID NO: 10 , SEQ ID NO: 11 , or SEQ ID NO: 12.2. The composition of claim 1 , wherein the derivative nucleic acid is at least 85% claim 1 , 90% claim 1 , 95% claim 1 , 96% claim 1 , 97% claim 1 , 98% claim 1 , or 99% identical to one of SEQ ID NO: 10 claim 1 , SEQ ID NO: 11 claim 1 , or SEQ ID NO: 12.3. The composition of claim 1 , wherein:(i) the nucleic acid comprises the sequence of SEQ ID NO: 10 and further comprises an antisense sequence of SEQ ID NO: 10; and/or(ii) the nucleic acid comprises the sequence of SEQ ID NO: 11 and further comprises an antisense sequence of SEQ ID NO: 11; and/or(iii) the nucleic acid comprises the sequence of SEQ ID NO: 12 and further comprises an antisense sequence of SEQ ID NO: 12;wherein when the sequence and the antisense sequence are hybridized together to form a duplex structure, the sequence and the antisense sequence are separated by a loop structure.4. The composition of claim 3 , wherein said nucleic acid is at least 43 nucleotides in length.5. The composition of claim 3 , wherein said nucleic acid is no more than 137 nucleotides in length.6. The composition of claim 3 , wherein the loop structure is between 5 and 19 nucleotides in length.7. The composition of claim 1 , wherein the derivative nucleic acid has 1 claim 1 , 2 claim 1 , 3 claim 1 , 4 claim 1 , or 5 mismatches compared to the respective SEQ ID NO:4 claim 1 , SEQ ID NO:5 claim 1 , SEQ ID NO:6 claim 1 , SEQ ID NO:7 claim 1 , SEQ ID NO:8 claim 1 , SEQ ID ...

CUSTOMIZABLE TOOL

A customizable hand tool system is presented. The customizable hand tool system includes a blade which is connected to an inner frame. The inner frame extends a length between a first end and a second end and includes a front stop positioned adjacent the front end and a rear stop positioned adjacent the second end. A cover is positioned around the inner frame between the front stop and the rear stop. A label, which the user or owner can customize, is positioned between the inner frame and the cover. As the cover is transparent or translucent, the label is easily seen through the cover. In this way, presented is a customizable hand tool that prevents misplacement or theft of the hand tool. 1. A customizable tool system , comprising:a blade;the blade connected to an inner frame;the inner frame extending a length between a first end and a second end;a front stop connected to the inner frame adjacent the first end;a rear stop connected to the inner frame adjacent the second end;a cover positioned around the inner frame;the cover positioned between and held by the front stop and the rear stop;a label positioned between the cover and the inner frame;wherein the label provides a customized identification of the tool.2. The customizable tool system of wherein the whole cover is transparent or translucent.3. The customizable tool system of wherein a portion of the cover is transparent or translucent.4. The customizable tool system of wherein the rear stop removably connects to the inner frame thereby allowing for removal and replacement of the cover and the label.5. The customizable tool system of wherein the rear stop has at least one locking member which locks to the inner frame when the rear stop and the inner frame are connected.6. The customizable tool system of wherein the inner frame has at least one locking member which locks to the rear stop when the rear stop and the inner frame are connected.7. The customizable tool system of wherein the inner frame and the rear ...

Systems and methods for providing a decentralized platform for connecting members of an open-science community

Systems and methods of managing research agreements between members in an open-science community are disclosed. A method includes recording a proposal from a researcher in a decentralized ledger, storing funds from a funder in the decentralized ledger, generating a first notification in the decentralized ledger that distributes an indicator to the researcher and the funder that a first portion of the research is to commence, recording deliverables from the researcher to the decentralized ledger, recording votes that indicate whether the deliverables comply with rules established from the proposal in the decentralized ledger, and when a majority of the votes indicates that the deliverables complies with the rules, distributing a tranche of the funds to the researcher and recording the distribution in the decentralized ledger and generating a second notification that distributes an indicator to the researcher and the funder that a second portion of the research is to commence.

FIRE RESISTANT ANTENNA APPARATUSES, SYSTEMS AND METHODS

An antenna or radiating element that is constructed of materials allowing for survivability of fire, high temperature, corrosive environments, or any combination of the aforementioned. Antennas are capable of operating for an extended period of time in a high temperature environment with the use of a radome having one or more surfaces covered in one or more of the following surface elements: a polyester film, a moldable plastic film, a boPET product, a ceramifiable silicone rubber material and a ceramic fiber wrap material. The surface elements can be used to construct a portion of the structural components of the antenna. 1. An antenna capable of operating for an extended period of time in a high temperature environment comprising a radome having one or more surfaces covered in one or more of the following surface elements: a polyester film , a moldable plastic film , a boPET product , a ceramifiable silicone rubber material and a ceramic fiber wrap material.2. The antenna capable of operating for an extended period of time in a high temperature environment of wherein the surface elements can be used to construct a portion of the structural components of the antenna.3. The antenna capable of operating for an extended period of time in a high temperature environment of wherein the radome is constructed of a ceramic material.4. The antenna capable of operating for an extended period of time in a high temperature environment of wherein silica aeroGel is used as an insulator in one or more locations inside the antenna.5. The antenna capable of operating for an extended period of time in a high temperature environment of wherein silica aeroGel is used as an insulator in one or more locations external to the antenna including one or more surfaces of the antenna.6. The antenna capable of operating for an extended period of time in a high temperature environment of wherein the antenna is capable of operating for more than one week.7. The antenna capable of operating for an ...

Press moulding method

A method of press moulding a moulding material to form a moulded part of fibre-reinforced resin matrix composite material, the method comprising the steps of: i. providing a mould tool having a lower mould part and an upper mould part, the upper mould part having a first moulding surface for moulding a first moulded surface of the moulded part and the lower mould part having a second moulding surface for moulding a second moulded surface of the moulded part; ii. providing a multilaminar panel of moulding material comprising at least one layer of fibres and at least one layer of resin, the multilaminar panel having first and second opposite major surfaces, a surface resin layer of the multilaminar panel being at or adjacent to the first major surface; iii. locating the moulding material in the mould tool; iv. closing the mould tool to define a substantially closed mould cavity containing the moulding material, the closing step including the sub-steps of: a. partially closing the mould tool to define a closed intermediate cavity containing the moulding material, the closed intermediate cavity being larger than the moulded part and the first moulding surface of the upper mould part being spaced from the first major surface, the upper mould part being at an elevated temperature as compared to the temperature of the moulding material; and b. at least partially evacuating air from the closed intermediate cavity while the first moulding surface of the upper mould part is spaced from the first major surface; v. applying pressure to the moulding material in the mould cavity to configure the moulding material in a fully moulded shape; and vi. substantially fully curing the resin to form a moulded part from the moulding material.

Expandable Baton With Locking Mechanism

A multi-section locking baton includes a manually actuatable release rod extending axially through outer, middle and inner tubes for unlocking first and second cam joints between the tubes. The release rod includes a tip having three sections, including an outermost or distal section that increases in diameter as measured in a direction moving away from the distal end of the tip; an intermediate section that is the widest section of the tip and that has a plurality of relief openings formed in as outer surface; and a proximal section that tapers from the intermediate section to a narrower diameter at the proximal tip end where it is secured onto the release rod. A portion of the release rod tip is located in one of the cams when the baton is in the extended condition. The baton also includes bushings on the inner diameters of the outer and middle tubes, and wear rings on the outer diameters of the middle and inner tubes. 1. A multi-section locking baton comprising:an outer tube;a middle tube telescoping within the outer tube,a first locking cam joint connecting the outer tube and the middle tube, including a first cam on the middle tube that has a central opening and a ball bearing with balls movable radially in response to axial movement of the first cam to releasably lock the outer tube to the middle tube;an inner tube telescoping within the middle tube,a second locking cam joint connecting the middle tube and the inner tube, including a second cam on the inner tube that has a central opening and a ball bearing movable radially in response to axial movement of the second cam to releasably lock the middle tube to the inner tube; anda manually actuatable release rod extending axially through the outer, middle and inner tubes for unlocking the first and second cam joints;the release rod including a tip having three sections, the three sections including an outermost or distal section that increases in diameter as measured in a direction moving away from the distal ...

MULTI-RANGE COMMUNICATION SYSTEM

A multi-range communication system is provided that can be expanded to support communications using both RF signals and millimeter wave signals without having to install entirely new systems to support communication of the signals. The communication system can use one or more shared optical fibers to simultaneously communicate both RF signals and millimeter wave signals in different ranges between network devices and mobile devices. The communication system permits the co-location of components for the communication system for the different ranges, which can result in substantially similar coverage areas for each of the ranges supported by the communication system. In addition, the corresponding equipment used for communicating signals in each of the ranges can be powered from a common DC power source. The supplied power can be configured for each piece of equipment, and corresponding range, such that the substantially similar coverage areas are obtained. 1. A distributed antenna system (DAS) for a communication system , comprising:a primary connection area comprising first equipment configured to communicate first signals in a first communication frequency range with a first network communications device and to communicate second signals in a second communication frequency range with a second network communications device, wherein the first communication frequency range is distinct from the second communication frequency range;a first optical fiber connected to the first equipment, the first optical fiber having at least one first strand for communication of first signals in the first communication frequency range and at least one second strand for communication of second signals in the second communication frequency range;a secondary connection area comprising second equipment connected to the first optical fiber;a second optical fiber connected to the second equipment, the second optical fiber having at least one first strand for communication of first signals in ...

Consumer products comprising cross-linked carbon nanotube sensors and systems and methods comprising the same

A consumer product having a sensor for controlling the operation of the consumer product, a system and method including the consumer product and a sensor are provided. The system and method including a central communication unit capable of receiving incoming signals and sending outgoing instructions from the consumer product and sensor. The central communication unit communicably connected with a memory configured to store an algorithm. The sensor has a cross-linked carbon nanotube network comprising: a plurality of carbon nanotubes; and at least one linker that covalently links adjacent carbon nanotubes. The algorithm controls the consumer product based on incoming signals sent from the sensor to the central communication unit.

Fiber Optic Distributed Vibration Sensing With Directional Sensitivity

Methods for determining separate velocity components of an acoustic wavefield that are incident on a distributed fiber optic sensor are disclosed. A fiber optic sensor includes fiber that is spatially distributed in non-parallel planes of a three-dimensional volume having three orthogonal axes. The fiber includes a first fiber pattern that is spatially distributed within a first plane of the three-dimensional volume, and a second fiber pattern that is spatially distributed within a second plane of the volume. The fiber patterns are interrogated separately by a distributed fiber optic interrogation system. The individual responses from each pattern are combined and processed to determine separate velocity components of the acoustic wavefield relative to the orthogonal axes of the three-dimensional volume. 1. A method of determining velocity components of an acoustic wavefield incident on a distributed fiber optic sensor , comprising: a first fiber pattern that is spatially distributed within a first plane of the three-dimensional volume; and,', 'a second fiber pattern that is spatially distributed within a second plane of the volume that is non-parallel to the first plane;, 'providing a distributed fiber optic sensor that is configured to provide a distributed response to an incident acoustic wavefield, the fiber optic sensor including fiber that is spatially distributed in planes of a three-dimensional volume having three orthogonal axes, the fiber includinglaunching optical energy into the fiber optic sensor to obtain individual responses from each of the first fiber pattern and the second fiber pattern to the incident acoustic wavefield, andprocessing the individual responses to determine separate velocity components of the acoustic wavefield relative to orthogonal axes of the three-dimensional volume.2. The method as recited in claim 1 , wherein the first fiber pattern has a first effective length and a second effective length along respective orthogonal axes of ...

Press moulding method

A method of press moulding a moulding material to form a moulded part of fibre-reinforced resin matrix composite material, the method comprising the steps of: i. providing a mould tool having a lower mould part and an upper mould part, the upper mould part having a first moulding surface for moulding a first moulded surface of the moulded part and the lower mould part having a second moulding surface for moulding a second moulded surface of the moulded part; ii. providing a multilaminar panel of moulding material comprising at least one layer of fibres and at least one layer of resin, the multilaminar panel having first and second opposite major surfaces, a surface resin layer of the multilaminar panel being at or adjacent to the first major surface and a dry fibre layer of the multilaminar panel forming the second major surface; iii. locating the moulding material in the mould tool by disposing the second major surface on the second moulding surface of the lower mould part, the lower mould part being at an elevated temperature as compared to the temperature of the moulding material; iv. closing the mould tool to define a substantially closed mould cavity containing the moulding material; v. applying pressure to the moulding material in the mould cavity to configure the moulding material in a fully moulded shape, and after the applying pressure step v the resin in the multilaminar panel fully impregnates the dry fibres; and vi. substantially fully curing the resin to form a moulded part from the moulding material.

Fiber Optic Distributed Vibration Sensing With Wavenumber Sensitivity Correction

An apparatus and method for correcting the wavenumber sensitivity of a distributed fiber optic sensor are disclosed. The distributed fiber optic sensor is deployed in a region of interest to measure a characteristic of an incident acoustic wavefield. A composite response of the distributed sensor is determined based on backscatter optical signals generated by the sensor, where the composite response is indicative of a characteristic of an incident acoustic wavefield. The composite response includes at least a first response having a first wavenumber sensitivity and a second response having a second wavenumber sensitivity. The second wavenumber sensitivity is selected so that wavenumber notches of the first and second responses do not overlap. 1. An apparatus , comprising:a distributed fiber optic sensor configured to provide a distributed response to an acoustic wavefield incident along its length;an interrogation and data acquisition system to obtain at least a first response and a second response of the distributed fiber optic sensor to the acoustic wavefield, the interrogation and data acquisition system including an optical source to launch optical pulses into the distributed fiber optic sensor and a detector to detect backscatter optical signals generated by the distributed fiber optic sensor in response to the launched optical pulses, wherein the first response corresponds to phase differences across a first differentiation interval applied to the detected backscatter optical signals, and the second response corresponds to phase differences across a second differentiation interval applied to the detected backscatter optical signals, wherein the first and second differentiation intervals are selected so that the first response has a first wavenumber sensitivity and the second response has a second wavenumber sensitivity that is different than the first wavenumber sensitivity; anda data processing system to combine the first and second responses to determine a ...

Window assembly

A window assembly includes a first pane of glass. The first pane of glass is chemically strengthened and exhibits a surface compressive stress of 400 MPa or more. A second pane of glass has a first major surface and a second major surface. The second major surface of the second pane of glass and a first major surface of the first pane of glass face each other. The second pane of glass includes 68-74 weight % SiO 2 , 2-6 weight % MgO, 1-10 weight % CaO, 12-16 weight % Na 2 O, 0-1 weight % K 2 O, 0.8-2.0 weight % Fe 2 O 3 (total iron), 0-1.25 weight % TiO 2 , and 0-1.25 weight % CeO 2 . A polymeric interlayer is provided between the first pane of glass and the second pane of glass. The window assembly exhibits a direct solar transmittance of 55% or less and a total solar transmittance of 65% or less.

CLOSED LOOP ANESTHETIC DELIVERY

A method for delivering a sedation drug comprising administering a drug to a patient while requesting the patient to respond to an instruction, monitoring a patient's BIS values, bringing the patient to a level of anesthesia where the patient fails to respond to the request within a predetermined response time, and determining a BIS value that coincides with the level of anesthesia corresponding to the failure to respond. 1. A method for delivering a sedation drug comprising the steps of:providing at least one device for infusing a sedation drug and for measuring a patient's index of depth of anesthesia;initially administering a sedation drug to a patient in an open loop mode while requesting the patient to respond to an instruction;monitoring a patient's index of depth of anesthesia;bringing the patient to a level of anesthesia where the patient fails to respond to the request within a predetermined response time;determining an index of depth of anesthesia value that coincides with the level of anesthesia where the patient fails to respond; andadjusting the administration of the sedation drug to the patient to a closed loop mode.2. The method of wherein the request is generated by an automated response monitoring system (ARM).3. The method of wherein the patient is brought to a level of anesthesia at which the patient does not respond to ARM.4. The method of wherein ARM includes:a controller which generates a request for a predetermined response from the patient and which analyses a response generated by the patient to the request for a predetermined response; and a request assembly which communicates to the patient the request generated by the controller; and', 'a response assembly which is used by the patient to generate the response and which communicates the response to the controller,', 'wherein at least one of the request assembly and the response assembly communicates at least one of the request and the response between the controller and the patient., 'a ...

Carbon-Based Direct Plating Process

A method of preparing a non-conductive substrate to allow metal plating thereon. The method includes the steps of a) contacting the non-conductive substrate with a conditioner comprising a conditioning agent; b) applying a carbon-based dispersion to the conditioned substrate, wherein the carbon-based dispersion comprises carbon or graphite particles dispersed in a liquid solution; and c) etching the non-conductive substrate. The etching step is performed before the liquid carbon-based dispersion dries on the non-conductive substrate. 1. A method of preparing a non-conductive substrate to allow metal plating thereon , the method comprising the steps of:a) conditioning the non-conductive substrate with a conditioning agent, wherein the conditioning agent comprises a conditioner having a molecular weight of at least 1,000,000 g/mol;b) applying a liquid carbon-based dispersion to the conditioned non-conductive substrate to form a carbon coating on the conditioned non-conductive substrate, wherein the carbon-based dispersion comprises carbon or graphite particles dispersed in a liquid solution, wherein the carbon particles coagulate onto the conditioned non-conductive substrate to form a carbon/conditioner gel coating; andc) etching the substrate.2. The method according to claim 1 , further comprising the step of drying the substrate and carbon-based dispersion after step c) to form a conductive carbon coating on the substrate3. The method according to claim 1 , further comprising the step of electroplating a conductive metal on the substrate after step c).4. (canceled)5. (canceled)6. (canceled)7. The method according to claim 1 , wherein the substrate comprises a printed circuit board or a printed wiring board.8. The method according to claim 1 , wherein the substrate is contacted with the conditioner by immersing the substrate in the conditioner for at least about 20 seconds.9. (canceled)10. (canceled)11. (canceled)12. The method according to claim 1 , wherein the ...

VENUE SEATING ANTENNA APPARATUSES, SYSTEMS AND METHODS

A stadium or arena seat with one or more embedded or placed antennas for use in wireless communication infrastructure. The antennas can be accommodated in a recessed area of the seat, embedded directly in the seat, in the armrest structure or the seat, or components of the one or more antennas may be partially located externally to any the seat's surfaces. 1. A venue arena seat apparatus with one or more embedded antennas for use in a wireless communication infrastructure wherein a user can connect one or more devices to the one or more embedded antennas to communicate with the wireless communication infrastructure.2. The venue arena seat apparatus of claim 1 , further comprising one or more wireless power transfer technology devices.3. The venue arena seat apparatus of claim 1 , further comprising one or more wired power transfer technology devices.4. The venue arena seat apparatus of claim 3 , wherein said wired power transfer technology device is a USB port.5. The venue arena seat apparatus of claim 1 , wherein the one or more embedded antennas are placed antennas.6. The venue arena seat apparatus of claim 1 , wherein the wireless communication infrastructure is a WiFi network.7. The venue arena seat apparatus of claim 1 , wherein the one or more antennas are self-optimizing wherein the output of said antenna is varied depending on the environment's requirements.8. The venue arena seat apparatus of claim 1 , further comprising a data connectivity device for gathering enhanced location and/or position information about one or more connected wireless devices.9. The venue arena seat apparatus of further comprising sensors to detect one or more of the following: acoustic disturbances and laser sources.10. A venue arena seat system comprising one or more embedded antennas for use in a wireless communication infrastructure wherein a user can connect one or more devices to the one or more embedded antennas to communicate with the wireless communication infrastructure.11 ...

SEDATION SYSTEM WITH MULTI-INPUT CAPNOMETER

An oral-nasal cannula receives exhaled gases from the nose and mouth of a patient. The exhaled gases are transported to variable flow valves that can variably restrict the flow of the gases through the valves upon software generated signals. The exhaled gases pass through the variable flow valves and mix so that they can be measured by a single sensor such as a sensor of a capnometer. Based upon information gathered by the capnometer, the variable valves can be adjusted in real-time according to a software method in order to identify a variable valve flow configuration that maximizes the amount of COreceived and measured by the capnometer. In this manner, the software can adapt a single capnometer to measure exhaled gases regardless of whether a patient breathes primarily through their nose or mouth or some proportion of the two. 1. An apparatus comprising:(a) an oral gas pathway configured to communicate gases exhaled orally by a patient;(b) a nasal gas pathway configured to communicate gases exhaled nasally through one or two nostrils of a patient;(c) an oral variable valve situated within the oral gas pathway, wherein the oral variable valve has an adjustable orifice that is configured to selectively restrict communication of gases exhaled orally through the oral gas pathway;(d) a nasal variable valve situated within the nasal gas pathway, wherein the nasal variable valve has an adjustable orifice that is configured to selectively restrict communication of gases exhaled nasally through the nasal gas pathway;(e) a capnometer, wherein the capnometer has a sensor configured to detect carbon dioxide in exhaled gas, wherein the capnometer is in fluid communication with the oral and nasal gas pathways such that the capnometer is configured to receive gases exhaled orally and nasally by a patient as restricted by the oral and nasal variable valves, respectively; and(f) a valve controller configured to receive data from the sensor of the capnometer, wherein the valve ...

SYSTEM AND METHOD FOR PROVIDING TRANSITIONAL MONITORING ALONG SEDATION CONTINUUM

A transition monitor receives data from a variety of sensors that provide data indicative of the level of sedation of a patient, such as a bispectral index monitor, automated responsiveness monitor, pulse oximeter, or other device. As data is received from a sensor device, the transition monitor will apply a weighting calculation and algorithm to the received value in order to determine a weighted value for the received data. The weighted value is used, along with prior values, to determine a sedated patient's position within a continuum of sedation levels, such as minimal sedation, moderate sedation, or deep sedation. When a newly received value triggers a transition from one sedation level to a next sedation level, one or more thresholds, safeguards, or drug delivery configurations may be modified to adapt to the change within the sedation continuum. 1. An apparatus comprising:(a) a sedation transition monitor, the sedation transition monitor comprising a memory, wherein the memory is configured to store a continuum stage indicator; and(b) a set of sensors, wherein the set of sensors is communicatively coupled with the sedation transition monitor, the set of sensors comprising a first sensor; (i) receive a set of sensor data from the set of sensors, wherein the set of sensor data comprises a first sensor data,', '(ii) identify the first sensor that the first sensor data originated from,', '(iii) determine a sedation stage value for the first sensor data using a first data weighting calculation, wherein the first data weighting calculation is selected by the sedation transition monitor based upon the identity of the first sensor and the continuum stage indicator,', '(iv) determine a new continuum value based at least in part upon the sedation stage value, and', '(v) update the continuum stage indicator to reflect the new continuum value., 'wherein the sedation transition monitor is configured to2. The apparatus of claim 1 , wherein the set of sensors further ...

SYSTEM AND METHOD FOR ADDRESSING HYPOXEMIA

A patient monitoring system is configured to monitor oxygen saturation and/or oxygenation of a patient's blood. The system is configured to re-oxygenate the patient in response to a determination that the patient's oxygen saturation and/or oxygenation has fallen below a threshold (e.g., if the patient is experiencing hypoxemia). A re-oxygenation routine may include an initial step of rapidly oxygenating the patient, followed by a reduction of oxygenation to make the oxygenation process more gradual. For instance, after the initial step of rapid oxygenation, the patient may be oxygenated with oxygen at an atmospheric level. The system may dynamically adjust the ratio of delivered oxygen versus delivered air, the duration of oxygenation, and the incidence of oxygenation. The system may also adjust the automated delivery of one or more drugs to the patient based on the patient's condition and/or the state of re-oxygenation. 1. An apparatus comprising:(a) a monitoring device, wherein the monitoring device is operable to monitor one or both of oxygenation of a patient or oxygen saturation of a patient; and (i) an oxygen delivery output; and', '(ii) an oxygen delivery controller;', 'wherein the oxygen delivery controller is configured to receive a first set of saturation data from the monitoring device;', 'wherein the oxygen delivery controller is configured to enter a dynamic re-oxygenation mode in response to receiving a set of saturation data indicating that a patient is experiencing hypoxemia;', 'wherein the oxygen delivery controller is configured to, upon entering the dynamic re-oxygenation mode, deliver oxygen at an initial delivery concentration via the oxygen delivery output;', 'wherein the oxygen delivery controller is further configured to receive a second set of saturation data from the monitoring device; and', 'wherein the oxygen delivery controller is further configured to perform a transition from the initial delivery concentration to a first transitional ...

PATIENT MONITORING SYSTEM WITH NETWORK OF TREATMENT EQUIPMENT

A patient preparing for a medical procedure is fitted with a modular connector device that stores patient data, medical procedure data, and other software. The patient connector can then be connected to other modular devices via wired or wireless means, allowing the other modular devices to access the patient connector storage to immediately identify the patient and determine its role within the medical procedure. The patient connector and each modular device may connect wirelessly to a localized network, allowing each device to communicate with each other or with a network server in order to receive updated information on a patient or medical procedure, or to download and configure new device drivers when two incompatible devices attempt to connect. In such a network, a patient may move seamlessly from room to room or from device to device without time consuming manual configurations. 1. An apparatus comprising:(a) a device network server configured to store a set of device network data, the set of device network data comprising a patient identifier associated with a patient and a set of medical procedure data associated with a medical procedure to be performed on the patient;(b) a patient connector comprising a memory and a first communication device, wherein the patient connector is configured to be located proximate to the patient; and(c) a medical procedure device comprising a second communication device, wherein the medical procedure device is configured to be non-operable;wherein the memory is configured to store a subset of device network data, the subset of device network data comprising the patient identifier;wherein the patient connector is configured to send, via the first communication device, an identifying signal to the second communication device in response to a connection being established between the first communication device and the second communication device, wherein the identifying signal comprises the subset of device network data;wherein ...

DRUG DELIVERY SYSTEM WITH DELIVERY BASED ON PATIENT DATA

Patient demographics gathered from a variety of sources are used to create one or more cumulative risk factors that is used to configure a set of initial drug delivery rules controlling factors such as dosing limits, lockouts, alarm thresholds, and informational displays. These initial drug delivery rules may then be modified during a procedure according to a pharmacodynamic profile that is created, updated, and maintained in real time based upon one or more sources of feedback, such as sensors providing information on patient responsiveness, patient cardiovascular conditions, patient pain levels, and clinician inputs. As the system proposes new or modified drug delivery conditions based upon demographic information and real time feedback, clinicians may review and accept or refuse the proposed changes. 1. A method comprising:(a) receiving a set of demographic information for a patient;(b) determining one or more cumulative risk factors based upon the set of demographic information;(c) configuring a set of medical devices with an initial profile based upon the one or more cumulative risk factors;(d) receiving a set of physiological information from a set of patient monitors, the set of physiological information describing one or more characteristics of a patient during a medical procedure;(e) maintaining, in real time, a pharmacodynamic profile based upon the set of physiological information; and(f) configuring the set of medical devices with a configuration profile based upon the pharmacodynamic profile.2. The method of claim 1 , wherein the set of demographic information comprises at least three of the following:(i) a patient height,(ii) a patient age,(iii) a patient's lean body mass,(iv) a patient body mass index,(v) a patient health classification,(vi) a patient ejection fraction,(vii) a prior medication history,(viii) an assessment of a patient's airway,(ix) a patient's gender,(x) a patient's ASA risk classification (I,II,III,IV,V)(xi) an objective anesthesia ...

Press With Drop Away Connecting Arm And Stroke Adjustment And Counter Weight Drive

A thermoforming trim press has one or more connecting arms for a movable platen which each have a pivotal connection between the adjacent ends of two adjacent sections into which each connecting arm is divided. The pivotal connection is normally locked to keep the sections in end to end alignment during normal press operation, but can be released to allow pivoting between the sections to be able to draw the movable platen further back from the normal retracted position to increase the available clearance when changing or maintaining tools mounted on the movable platen. The pivoting ability of the connecting arm sections also simplifies adjusting the stroke of the press while this is normally done by relocating a crank pin on flywheels driving the connecting arms. The change of position does not affect the movable platen when the arm sections may pivot with respect to each other allowing relocating the crank pins to adjust the stroke without requiring disassembling of the crank pins. A counterweight may be driven by the crank pins to match the press stroke adjustments and to thereby correspond the movement of the counterweight to the movement of the movable platen. 1. A press having a movable platen adapted to mount a tool for carrying out an operation by said press , said movable platen connected to one end of an elongated connecting arm , an opposite end of said connecting arm driven by a press drive to reciprocate said tool between fully retracted and fully advanced positions , said connecting arm divided into two sections , each section having an end adjacent an end of the other of said two sections , said adjacent ends joined together by an interposed pivot connection , with a locking arrangement normally operative on said pivot joint to prevent pivoting motion and hold said sections in lengthwise alignment , said locking arrangement selectively able to be released to allow said pivoting of said arm sections relative each other and to thereby draw said platen ...

COMPOUNDS HAVING ANTIBACTERIAL ACTIVITY AND METHODS OF USE

In one aspect, methods of treating bacterial infections are described herein employing compounds having more than one target for antibacterial activity. Additionally pharmaceutical compositions comprising such compounds are also described. 2. The method of claim 1 , wherein bacteria of the infection are gram negative.3. The method of claim 1 , wherein bacteria of the infection are gram positive.4. The method of claim 1 , wherein the bacterial infection is resistant to one or more antibiotic compounds differing from the compound of Formula 1.5. The method of claim 1 , wherein the compound of Formula (I) is administered at a concentration of 0.1 μg/ml to 100 μg/ml.6. The method of claim 1 , wherein the compound of Formula (I) exhibits more than one target for antibacterial activity.7. The method of claim 6 , wherein the compound of Formula (I) targets bacterial folate metabolism.8. The method of claim 7 , wherein the compound of Formula (I) targets membrane polarization and/or membrane permeability.9. The method of claim 1 , wherein Ris selected from the group consisting of cycloalkyl and heterocycloalkyl and Ris selected from the group consisting of alkyl claim 1 , cycloalkyl claim 1 , heterocycloalkyl claim 1 , aryl and heteroaryl.12. The pharmaceutical composition of claim 11 , wherein the compound of Formula (I) exhibits antibacterial activity.13. The pharmaceutical composition of claim 12 , wherein the compound of Formula (I) exhibits more than one target for antibacterial activity.14. The method of claim 13 , wherein the compound of Formula (I) targets bacterial folate metabolism.15. The method of claim 14 , wherein the compound of Formula (I) targets membrane polarization and/or membrane permeability.16. The method of claim 11 , wherein Ris selected from the group consisting of cycloalkyl and heterocycloalkyl and Ris selected from the group consisting of alkyl claim 11 , cycloalkyl claim 11 , heterocycloalkyl claim 11 , aryl and heteroaryl.17. The method of ...

HIPPO PATHWAY DEFICIENCY REVERSES SYSTOLIC HEART FAILURE POST-INFARCTION

Embodiments of the disclosure include methods and compositions related to treating or reducing the severity or delaying the onset of one or more cardiac conditions in a mammal In particular embodiments, the compositions concern Park2 and its use for a cardiac medical condition. In specific cases, effective amounts of Park2 polynucleotide(s) and/or Park2 polypeptide(s) are provided to an individual in need thereof, including for heart failure, for example. The administration may be locally to the heart, for example. 1. A method of treating an individual for a cardiac condition , comprising the step of providing an effective amount of a Park2 nucleic acid composition and/or Park2 polypeptide composition to the individual.2. The method of claim 1 , wherein the cardiac condition in the individual causes the individual to be in need of cardiomyocyte renewal.3. The method of claim 1 , wherein the heart of the individual has cardiomyocyte apoptosis claim 1 , necrosis claim 1 , and/or autophagy.4. The method of claim 1 , wherein the cardiac condition comprises cardiovascular disease claim 1 , cardiomyopathy claim 1 , heart failure claim 1 , myocardial infarction claim 1 , ischemia claim 1 , necrosis claim 1 , fibrosis claim 1 , or diabetic cardiomyopathy claim 1 , age-related cardiomyopathy.5. The method of claim 1 , wherein the individual has Duchenne muscular dystrophy.6. The method of claim 1 , wherein the composition is provided to the individual more than once.7. The method of claim 1 , wherein the composition is provided to the individual systemically.8. The method of claim 1 , wherein the composition is provided to the individual locally.9. The method of claim 8 , wherein the composition is provided locally to the heart of the individual.10. The method of claim 1 , wherein the method further comprises providing to the individual an effective amount of an agent that targets Salvador (Salv) nucleic acid or protein.11. The method of claim 10 , wherein the agent that ...

FOOD RECEPTACLE

A food receptacle includes a top surface for retaining food and the top surface has a perimeter, an outer wall connected to the perimeter, a finger slot in the outer wall, a bottom surface with a finger channel, the finger channel corresponding to a ridge in the top surface, and a fastener that releasably attaches the receptacle to an external surface, wherein the fastener, finger slot, and finger channel are arranged so that a finger can be inserted through the finger slot and finger channel in a direction toward the fastener, and wherein the finger slot and finger channel provide a substantially unobstructed linear path to the fastener. 1. A food receptacle comprising:a top surface for retaining food, the top surface comprising a perimeter;an outer wall connected to the perimeter;a finger slot in the outer wall;a bottom surface comprising a finger channel, the finger channel corresponding to a ridge in the top surface;a fastener that releasably attaches the receptacle to an external surface, wherein the fastener, finger slot, and finger channel are arranged so that an adult sized finger can be inserted through the finger slot and finger channel in a direction toward the fastener, wherein the finger slot and finger channel provide a substantially unobstructed linear path to the fastener, and wherein the substantially unobstructed linear path has a length of at least about 22 mm and a cross-section at least about 13 mm wide and 22 mm high throughout the unobstructed linear path.2. The food receptacle of claim 1 , wherein the receptacle has a central axis and the finger channel and finger slot are oriented at an angle from the central axis between 10 and 40 degrees.3. The food receptacle of claim 1 , wherein the fastener is a suction device.4. The food receptacle of claim 3 , wherein the height of the outer wall approximates the height from the bottom of the fastener to a point on the top surface where the outer wall connects to the perimeter when the fastener is not ...

An apparatus for supporting a heavy vehicle brake assembly

An apparatus configured to engage and support a heavy vehicle brake assembly to facilitate removal and installation. The apparatus comprises a drum and hub engagement assembly configured to engage an accessible portion of an in-situ drum and/or hub assembly and to support the drum and/or hub assembly when so engaged for transport between an in-situ position and a removed position. The apparatus includes a lifting assembly having an upright guide assembly and a lifting device for raising and lowering the drum and hub engagement assembly. The lifting device is configured to raise and lower the drum and hub engagement assembly and the drum and/or hub assembly engaged thereby along the upright guide assembly in a vertical line. The apparatus is configured to be positionable relative to the brake assembly and movable away from the vehicle to facilitate removal of the brake assembly.

COMPOUNDS HAVING ANTIBACTERIAL ACTIVITY AND METHODS OF USE

In one aspect, methods of treating bacterial infections are described herein employing compounds having more than one target for antibacterial activity. Additionally, pharmaceutical compositions comprising such compounds are also described. 2. The pharmaceutical composition of claim 1 , wherein the compound of Formula (I) is present in the pharmaceutical composition at a concentration of 0.1 μg/ml to 10 μg/ml.3. The pharmaceutical composition of claim 1 , wherein Ris aryl.4. The pharmaceutical composition of claim 3 , wherein the aryl is a multicyclic ring system.5. The pharmaceutical composition of claim 1 , wherein X and Z are C.6. The pharmaceutical composition of claim 1 , wherein Rand Rare hydrogen.7. The pharmaceutical composition of claim 3 , wherein R claim 3 , R claim 3 , R claim 3 , Rand claim 3 , Rare each hydrogen claim 3 , and X and Z are each C.8. The pharmaceutical composition of claim 7 , wherein the aryl of Ris a multicyclic ring system.9. The pharmaceutical composition of claim 8 , wherein the compound of Formula (I) is present in the pharmaceutical composition at a concentration of 0.1 μg/ml to 10 μg/ml.10. The pharmaceutical composition of claim 1 , wherein the cells are bacteria cells.11. The pharmaceutical composition of claim 10 , wherein the bacteria cells are gram negative.12. The pharmaceutical composition of claim 1 , wherein the cells are cancer cells.14. The method of claim 13 , wherein the concentration is 0.1 μg/ml to 10 μg/ml.15. The method of claim 13 , wherein Ris aryl.16. The method of claim 15 , wherein the aryl is a multicyclic ring system.17. The method of claim 13 , wherein X and Z are C.18. The method of claim 10 , wherein Rand Rare hydrogen.19. The method of claim 15 , wherein R claim 15 , R claim 15 , R claim 15 , Rand claim 15 , Rare each hydrogen claim 15 , and X and Z are each C.20. The method of claim 19 , wherein the aryl of Ris a multicyclic ring system.21. The method of claim 20 , wherein the compound of Formula (I) ...

Press moulding method

A method of press moulding a moulding material to form a moulded part of fibre-reinforced resin matrix composite material, the method comprising the steps of: i. providing a mould tool having a lower mould part and an upper mould part, the upper mould part having a first moulding surface for moulding a first moulded surface of the moulded part and the lower mould part having a second moulding surface for moulding a second moulded surface of the moulded part; ii. providing a multilaminar panel of moulding material comprising at least one layer of dry fibres and at least one layer of resin, the multilaminar panel having first and second opposite major surfaces; iii. locating the moulding material in the mould tool; iv. progressively closing the mould tool to define a substantially closed mould cavity containing the moulding material, the closing step having: I. a first stage prior to both the first moulding surface contacting the first major surface and the second moulding surface contacting the second major surface and II. a second compression stage after both the first moulding surface has contacted the first major surface and the second moulding surface has contacted the second major surface, the second compression stage causing resin impregnation of the dry fibres,  the closure speed of relative movement between the lower and upper mould parts being higher in the first stage than in the second compression stage; v. applying pressure to the moulding material in the mould cavity to configure the moulding material in a fully moulded shape; and vi. substantially fully curing the resin to form a moulded part from the moulding material.

SYSTEM AND METHOD FOR GRAPHICALLY BUILDING WEIGHTED SEARCH QUERIES

A system and method allows a user to define a search request by selecting and weighting graphical icons provided on a search creation interface. The graphical icons may be selected by using an icon selection feature provided on the search creation interface. The graphical icons may further be assigned relative search weights using an icon weighting feature provided on the search creation interface. The system and method generates search results based on metadata associated with the selected ones of the graphical icons and the search weights assigned to each of the selected ones of the graphical icons. The search results may comprise a ranked list of items, such as products listed for sale on an e-commerce server. 1. A method of performing an electronic search of a database , said method comprising:generating a search creation interface on a display of a user electronic device, the search creation interface providing a set of graphical icons, an icon selection tool, and an icon weighting tool;processing user input acquired through user interaction with the icon selection tool to define selected ones of the graphical icons from the set of graphical icons;processing user input acquired through user interaction with the icon weighting tool to define a search weighting preference for each of the selected ones of the graphical icons;processing the selected ones of the graphical icons to generate a ranked item list for each of the selected ones of the graphical icons;processing the search weighting preferences and the ranked item lists for the selected ones of the graphical icons to generate a weighted ranked item list for each of the selected ones of the graphical icons;processing the weighted ranked item lists for the selected ones of the graphical icons to form a combined ranked item list; anddisplaying the combined ranked item list on the display of the user.2. The method of claim 1 , wherein the icon selection tool provides a drag and drop feature such that the user ...

HIPPO AND DYSTROPHIN COMPLEX SIGNALING IN CARDIOMYOCYTE RENEWAL

Embodiments of the disclosure include methods and compositions for the renewal of cardiomyocytes by targeting the Hippo pathway. In particular embodiments, an individual with a need for cardiomyocyte renewal is provided an effective amount of a shRNA molecule that targets the Sav1 gene. Particular shRNA sequences are disclosed. 1. An isolated synthetic nucleic acid composition , comprising SEQ ID NO:4 , SEQ ID NO:5 , SEQ ID NO:6 , SEQ ID NO:7 , SEQ ID NO:8 , SEQ ID NO:9 , SEQ ID NO:10 , SEQ ID NO:11 , or SEQ ID NO:12 and/or a derivative nucleic acid comprising at least 80% identity to one of SEQ ID NO:4 , SEQ ID NO:5 , SEQ ID NO:6 , SEQ ID NO:7 , SEQ ID NO:8 , SEQ ID NO:9 , SEQ ID NO:10 , SEQ ID NO:11 , or SEQ ID NO:12.2. The composition of claim 1 , wherein the derivative nucleic acid is at least 85% claim 1 , 90% claim 1 , 95% claim 1 , 96% claim 1 , 97% claim 1 , 98% claim 1 , or 99% identical to one of SEQ ID NO:4 claim 1 , SEQ ID NO:5 claim 1 , SEQ ID NO:6 claim 1 , SEQ ID NO:7 claim 1 , SEQ ID NO:8 claim 1 , SEQ ID NO:9 claim 1 , SEQ ID NO:10 claim 1 , SEQ ID NO:11 claim 1 , or SEQ ID NO:12.3. The composition of claim 1 , wherein the nucleic acid comprises the sequence of SEQ ID NO:4 and further comprises an antisense sequence of SEQ ID NO:4 claim 1 , wherein when the sequence and the antisense sequence are hybridized together to form a duplex structure claim 1 , the sequence and the antisense sequence are separated by a loop structure.4. The composition of claim 1 , wherein the nucleic acid comprises the sequence of SEQ ID NO:5 and further comprises an antisense sequence of SEQ ID NO:5 claim 1 , wherein when the sequence and the antisense sequence are hybridized together to form a duplex structure claim 1 , the sequence and the antisense sequence are separated by a loop structure.5. The composition of claim 1 , wherein the nucleic acid comprises the sequence of SEQ ID NO:6 and further comprises an antisense sequence of SEQ ID NO:6 claim 1 , wherein when the ...

Tinted float glass

A tinted float glass includes a base glass portion comprising: SiO 2 68-75 wt % Al 2 O 3 0-3 wt % Na 2 O 11-15 wt % K 2 O 0-3 wt % CaO 6-11 wt % MgO 2-6 wt % and a colourant portion comprising iron, cobalt and selenium in the following ranges: Fe 2 O 3 0.30-0.40 wt % Co 3 O 4 46-60 ppm Se 1-5 ppm The tinted float glass is blue-grey in transmitted colour, and is suitable for architectural, automotive, and other applications. A particularly preferred embodiment of the glass has a colourant portion comprising 0.31-0.33% Fe 2 O 3 , 51-55 ppm Co 3 O 4 and 2-4 ppm selenium, together with a light transmission (Ill D65) of 59 to 62%, a dominant wavelength of 482 nm, a colour purity of 7 to 8%, and a performance of 3 to 7%; all in a sample 6.0 mm thick. The glass may be coated with a low emissivity coating.

Ring Seal With Sealing Surface Extension

A ring seal for sealing opposing flow component sealing surfaces defines a fluid flow path that is suitable for applications such as a semiconductor manufacturing modular gas delivery system. The ring seal includes an annular extension in the form of a modified “delta” extending from one or both sealing surfaces of the ring seal. The modified “delta” extends to an apex or point above the ring seal's sealing surface. First and second extension surfaces extend in opposite directions from the apex back toward the ring seal's sealing surface. In one aspect, the first extension surface defines a ridge where the slope of the first extension surface changes to decline faster to the ring seal's sealing surface. In another aspect, the apex is located within the annular extension closer to the axial hole than to an outer radial diameter of the annular seal body.

SYSTEM FOR MONITORING AND/OR SURVEYING CONDUITS

A method for inspecting a conduit comprising the steps of: emitting an outgoing signal into the conduit to establish an acoustic plane wave within the conduit; and detecting a reflected outgoing signal from the conduit, wherein the outgoing signal is arranged such that low frequency components contribute to more of the outgoing signal, from a time perspective, than high frequency components. 1. A method for inspecting a conduit comprising the steps of:co-locating an acoustic source with a detector;emitting a swept signal into the conduit from the source to establish an acoustic plane wave within the conduit, the acoustic plane wave being a guided wave; anddetecting a reflected signal from the conduit using the detector, wherein the emitted signal is arranged such that low frequency components contribute to more of the swept signal, from a time perspective, than high frequency components.2. (canceled)3. The method according to claim 1 , wherein the emitted signal is an acoustic impulse.46-. (canceled)7. The method according to claim 1 , wherein the emitted signal relates to a linear frequency sweep.8. The method according to claim 1 , wherein the emitted signal relates to a non-linear frequency sweep.910-. (canceled)11. The method according to claim 1 , for determining a condition of the conduit claim 1 , wherein the condition is a blockage and the blockage is an improvised explosive device (IED) in the conduit.12. The method according to claim 1 , wherein the conduit being inspected is a large diameter conduit having a diameter above 25 centimetres.13. The method according to claim 1 , wherein the conduit is selected from the group consisting of: a pipe claim 1 , a pipeline claim 1 , a culvert claim 1 , a sewer claim 1 , a drain claim 1 , and a tunnel.1416-. (canceled)17. The method according to claim 1 , wherein the detector is selected from the group consisting of: an acoustic transducer claim 1 , a speaker claim 1 , a microphone claim 1 , a hydrophone claim 1 , ...

Tunable Microwave Devices with Auto-Adjusting Matching Circuit

An embodiment of the present disclosure provides a circuit including an antenna having a tunable component. The tunable component can be operable to receive a variable signal to cause the tunable component to change a reactance of the antenna. The tunable component can include a first conductor coupled to the antenna, a second conductor, and a tunable material positioned between the first conductor and the second conductor, where at least one of the first conductor or the second conductor, or both are adapted to receive the variable signal to cause the change in the reactance of the antenna. Additional embodiments are disclosed. 1. A variable circuit , comprising:a matching network coupleable to a tunable device;wherein the matching network comprises a first port and a second port;wherein the tunable device is coupled to one of the first port or the second port;wherein the matching network comprises one or more variable capacitors;wherein the one or more variable capacitors are operable to receive a first signal to cause the one or more variable capacitors to change a first reactance of the matching network; andwherein the tunable device is operable to receive a second signal to cause a change in a second reactance of the tunable device.2. The variable circuit of claim 1 , wherein the tunable device is a tunable antenna.3. The variable circuit of claim 1 , wherein the change in the first reactance of the matching network causes an increase in power transferred from the first port to the second port or from the second port to the first port.4. The variable circuit of claim 1 , wherein the change in the second reactance of the tunable device causes an increase in power transferred from the first port to the second port or from the second port to the first port.5. The variable circuit of claim 1 , wherein the one or more variable capacitors comprise tunable material comprising a composition of barium strontium titanate.6. The variable circuit of claim 5 , wherein the ...

AGRICULTURAL ADJUVANTS AND PROCESSES FOR MAKING AND USING SAME

An agricultural spray pre-mix composition, comprising from 0.01 wt % to 40 wt % of an agricultural spray adjuvant comprising a vinyl ester-based or vinyl acrylate-based polymer dispersion and greater than 15 wt % of a plasticizer and from 1 wt % to 50 wt % of a water conditioning agent. 1. An agricultural spray pre-mix composition , comprising: [ 'a plasticizer; and', 'a vinyl ester-based or vinyl acrylate-based polymer dispersion; and'}, 'a water conditioning agent., 'an agricultural spray adjuvant comprising2. The pre-mix composition of claim 1 , wherein the vinyl ester-based or vinyl acrylate-based polymer dispersion comprises polyvinyl alcohols claim 1 , polyethylene oxides claim 1 , polyethylene glycols claim 1 , polypropylene glycols claim 1 , polyvinyl pyrrolidones claim 1 , polyacrylamide claim 1 , methylcelluloses claim 1 , hydroxyethylcelluloses claim 1 , hydroxypropylcelluloses claim 1 , sodium carboxymethylcellulose claim 1 , gelatins claim 1 , caseins claim 1 , starches claim 1 , gums claim 1 , hydroxy ethyl starches claim 1 , or sodium alginates claim 1 , or any combinations thereof.3. The pre-mix composition of claim 2 , wherein the polyvinyl alcohols claim 2 , polyethylene oxides claim 2 , polyethylene glycols claim 2 , polypropylene glycols claim 2 , polyvinyl pyrrolidones claim 2 , polyacrylamide claim 2 , methylcelluloses claim 2 , hydroxyethylcelluloses claim 2 , hydroxypropylcelluloses claim 2 , sodium carboxymethylcellulose claim 2 , gelatins claim 2 , caseins claim 2 , starches claim 2 , gums claim 2 , hydroxy ethyl starches claim 2 , or sodium alginates claim 2 , or any combinations thereof is/are dissolved in the aqueous phase.4. The pre-mix composition of claim 1 , wherein the plasticizer is dissolved in the aqueous phase.5. The pre-mix composition of claim 1 , wherein the adjuvant is present in an amount ranging from 0.01 wt % to 40 wt % claim 1 , based on the total weight of the pre-mix composition and wherein the water conditioning agent ...

Carbon-Based Direct Plating Process

A method of preparing a non-conductive substrate to allow metal plating thereon. The method includes the steps of a) contacting the non-conductive substrate with a conditioner comprising a conditioning agent; b) applying a carbon-based dispersion to the conditioned substrate, wherein the carbon-based dispersion comprises carbon or graphite particles dispersed in a liquid solution; and c) etching the non-conductive substrate. The etching step is performed before the liquid carbon-based dispersion dries on the non-conductive substrate. 1. A method of preparing a non-conductive substrate to allow metal plating thereon , the method comprising the steps of:a) conditioning the non-conductive substrate with a conditioning agent;b) applying a liquid carbon-based dispersion to the conditioned non-conductive substrate to form a carbon coating on the conditioned non-conductive substrate, wherein the carbon-based dispersion comprises carbon or graphite particles dispersed in a liquid solution; andc) etching the substrate,wherein the etching step is performed before the liquid carbon-based dispersion dries on the non-conductive substrate.2. The method according to claim 1 , further comprising the step of drying the substrate and carbon-based dispersion after step c) to form a conductive carbon coating on the substrate.3. The method according to claim 2 , further comprising the step of electroplating a conductive metal on the substrate after step c).4. The method according to claim 1 , wherein the conditioning agent comprises a conditioner having a molecular weight of at least 100 claim 1 ,000 g/mol.5. The method according to claim 4 , wherein the conditioner has a molecular weight of at least 500 claim 4 ,000 g/mol.6. The method according to claim 5 , wherein the conditioner has a molecular weight of at least 1 claim 5 ,000 claim 5 ,000 g/mol.7. The method according to claim 1 , wherein the substrate comprises a printed circuit board or a printed wiring board.8. The method ...

Compounds for the treatment of metabolic disorders

The present invention is directed to therapeutic compounds which have activity as agonists of GPR119 and are useful for the treatment of metabolic disorders including type II diabetes (I).

Heterocyclic gpcr agonists

Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR (GPR119) agonists and are useful as for the treatment of diabetes and obesity.

Heterocyclic gpcr agonists

Compounds of formula (I) or pharmaceutically acceptable salts thereof, are GPCR (GPR119) agonists and are useful as for the treatment of diabetes and obesity.

Compounds for the treatment of metabolic disorders

The present invention is directed to therapeutic compounds which have dual activity as agonists of GPR119 and inhibitors of DPP-IV and are useful for the treatment of metabolic disorders including type II diabetes.

Heterocyclic gpcr agonists

Compounds of formula (I) or pharmaceutically acceptable salts thereof, are agonists of GPR119 and are useful as regulators of satiety, e.g. for the treatment of obesity, and for the treatment of diabetes.

G-protein coupled receptor agonists

Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.

Gpcr agonists

Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.

Gpcr agonists

Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.

Gpcr agonists

Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.

1,4 di substituted pyrrolidine - 3 - yl -amine derivatives and their use for the treatment of metabolic disorders

Therapeutic compounds are disclosed having the general formula (1) that are useful for the treatment of metabolic disorders, including type II diabetes.The compounds have activity as agonists of GPR1 19. Compounds having the stereochemistry of formula (la) may also demonstrate DPP-IV inhibitory activity.

Resorcinol derivatives

The present invention relates to the use of certain resorcinol derivatives as skin lightening agents.

Filled polymer compositions

A filled polymer composition which comprises A) from about 5 to about 90 percent of one or more thermoplastic substantially random interpolymers prepared by polymerizing one or more a-olefin monomers with one or more vinylidene aromatic monomers and/or one or more hindered aliphatic or cycloaliphatic vinylidene monomers, and optionally with other polymerizable ethylenically unsaturated monomer(s), and (B) from about 10 to about 95 percent of one or more inorganic fillers, the amounts of (A) and (B) being based on the total weight of (A) and (B). Fabricated articles made from the filled polymer compositions are useful as sound insulating or energy absorbing films or sheets or as floor, wall or ceiling coverings.

Filled polymer compositions

A filled polymer composition which comprises (A) from about 5 to about 90 percent of one or more thermoplastic substantially random interpolymers prepared by polymerizing one or more α-olefin monomers with one or more vinylidene aromatic monomers and/or one or more hindered aliphatic or cycloaliphatic vinylidene monomers, and optionally with other polymerizable ethylenically unsaturated monomer(s), and (B) from about 10 to about 95 percent of one or more inorganic fillers, the amounts of (A) and (B) being based on the total weight of (A) and (B). Fabricated articles made from the filled polymer compositions are useful as sound insulating or energy absorbing films or sheets or as floor, wall or ceiling coverings.

Steady frame rate volumetric ultrasound imaging

The present invention relates to a method for providing three-dimensional ultrasound images of a volume (50) and an ultrasound imaging system (10). In particular, the current invention applies to live three-dimensional imaging. To maintain a steady frame rate of the displayed images even if a user changes a region of interest and, therewith, the size of the volume (50) to be scanned, it is contemplated to adjust a density of the scanning lines within the volume (50) as a function of a size of the volume while maintaining a total number of scanning lines across the volume (50).

Polyvinyl chloride compositions

A polyvinyl chloride composition having polyvinyl chloride resin and a plasticizer ester selected from di-butyl terephthalate, di-isobutyl terephthalate, or mixtures thereof.

Terephthalates as plasticizers in vinyl acetate polymer compositions

An aqueous composition adhesive composition comprising a vinyl acetate polymer and a plasticizer having Formula (I), wherein R 1 and R 2 are independently selected from the group consisting of saturated straight or branched and unsubstituted alkyl or cycloalkyl groups having from 4 to 8 carbon atoms.

Sealant compositions having a novel plasticizer

Terephthalates as plasticizers in vinyl acetate polymer compositions

An aqueous composition adhesive composition comprising a vinyl acetate polymer and a plasticizer having the general formula: wherein R 1 and R 2 are independently selected from the group consisting of saturated straight or branched and unsubstituted alkyl or cycloalkyl groups having from 4 to 8 carbon atoms.

Sealant compositions having a novel plasticizer

A sealant composition having from about 0.1 to about 90 weight % of a polymer selected from the group consisting of butyls, acrylics, urethanes, polysulfides, and silicone modified polymers, and at least one C 4 to C 8 alkyl terephthalate.

Polyvinyl chloride compositions

A polyvinyl chloride composition having polyvinyl chloride resin and a plasticizer ester selected from di-butyl terephthalate, di-isobutyl terephthalate, or mixtures thereof.

Terephthalates as plasticizers in vinyl acetate polymer compositions

An aqueous composition adhesive composition comprising a vinyl acetate polymer and a plasticizer having the general formula: wherein R 1 and R 2 are independently selected from the group consisting of saturated straight or branched and unsubstituted alkyl or cycloalkyl groups having from 4 to 8 carbon atoms.

Automatic dishwashing composition

A neutral or acidic automatic dishwashing detergent composition comprising a perfume wherein the perfume comprises at least one ester-comprising perfume raw material having the following formula: wherein R1 and R2 are independently selected from: i) unbranched linear alkyls or alkenyls; and ii) branched linear alkyls or alkenyls wherein if the branching is in an alpha or beta position the branching is CH3 or a pendant cyclic group.

Methods of applying compositions to webs

A method of printing composition(s) on a web is disclosed. The method includes the steps of advancing the web and printing a plurality of composition sites on the web. The method further includes the step of forming one or more discontinuities in the web. The discontinuities correspond to the printed composition sites.

1,4 disubstituted pyrrolidine - 3 - yl -amine derivatives and their use for the treatment of metabolic disorders

Therapeutic compounds are disclosed having the general formula (I) that are useful for the treatment of metabolic disorders, including type II diabetes. The compounds have activity as agonists of GPR1 19. Compounds having stereochemistry of formula (la) may also demonstrate DPP-IV inhibitory activity.

Methods and kits for cell activation

Provided are methods and kits for activating T cells, the method comprising providing a population of T cells, adding a plurality of first agents, where the first agent comprises a T-cell activator and a first binder moiety, and adding a second agent comprising a plurality of capture oligomers, where at least a segment of at least one of the plurality of capture oligomers is capable of associating with the first binder moiety. The method further comprises incubating the population of T cells, whereby at least a portion of the population of T cells is activated.

compound or a pharmaceutically acceptable salt thereof, pharmaceutical composition, and use and process for the preparation of a compound or a pharmaceutically acceptable salt thereof

<b>COMPOSTO OU UM SAL FARMACEUTICAMENTE ACEITáVEL DO MESMO, COMPOSIçãO FARMACêUTICA, E, USO E PROCESSO PARA A PREPARAçãO DE UM COMPOSTO OU UM SAL FARMACEUTICAMENTE ACEITAVEL DO MESMO<d> São descritos compostos da Fórmula (I): (fórmula) ou sais farmaceuticamente aceitáveis dos mesmos, que são usados no tratamento profilático e terapêutico de hiperglicemia e diabete. <b> COMPOUND OR A PHARMACEUTICALLY ACCEPTED SALT OF THE SAME, PHARMACEUTICAL COMPOSITION, AND, USE AND PROCESS FOR THE PREPARATION OF A COMPOUND OR A PHARMACEUTICALLY ACCEPTABLE SALT <d> Compounds of Formula (I) are described: (formula) or salts pharmaceutically acceptable therapeutics, which are used in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.

Resorcinol derivatives

The present invention relates to resorcinol derivatives of formula I, in which R is a (C3-C8)cycloalkyl ring or a (C5-C8)cycloalkenyl ring substituted by one of -N(R1)SO2(CHR1)nR2 and (C1-C6)alkyIN(R1)SO2(CHR1)nR2, wherein R1, R2 and n are as defined in the claims, and their use as skin lightening agents.

Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases

Novel [1.2.4]triazolo[1,5-a]pyrazine and imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: Formula (Ia) or Formula (Ib). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

Benzyl urea and thiourea derivatives useful as androgen antagonists

The present invention is directed to a new class of 6-benzyl urea/thiourea-quinolin-2-one derivatives and 2-oxo-6-benzylurea/thiourea-chromene derivatives of the formula (I). These compound are androgen antagonists and are useful in the treatment of alopecia, acne and other conditions associated with inappropriate activation of the androgen receptor.

Heterocyclic gpcr agonists

Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR (GPR119) agonists and are useful as for the treatment of diabetes and obesity.

Bicyclic aryl and heteroaryl receptor modulators

Compounds of formula (I) or pharmaceutically acceptable salts thereof, are opioid receptor modulators, e.g. mu-opioid receptor antagonists, neutral antagonists or inverse agonists, and are useful inter alia for the treatment of obesity.

Compounds and pharmaceutical compositions thereof for the treatment of cystic fibrosis

The present invention discloses compounds according to Formula I: wherein R 1 is as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment cystic fibrosis by administering a compound of the invention.

Press moulding method

A method of press moulding a moulding material to form a moulded part of fibre-reinforced resin matrix composite material, the method comprising the steps of: i. providing a mould tool having a lower mould part (58) and an upper mould part (60), the upper mould part (60) having a first moulding surface (62) for moulding a first moulded surface of the moulded part and the lower mould part (58) having a second moulding surface (64) for moulding a second moulded surface of the moulded part; ii. providing a multilaminar panel of moulding material (66) comprising at least one layer of fibres and at least one layer of resin, the multilaminar panel having first and second opposite major surfaces (68, 70); iii. locating the moulding material (66) in the mould tool; iv. progressively closing the mould tool to define a substantially closed mould cavity (90) containing the moulding material (66), the closing step including: a. a preliminary closing phase to achieve mutual engagement between the lower and upper mould parts (58, 60), b. a secondary closing phase after engagement between the lower and upper mould parts with the mould tool partially closed to define a closed intermediate cavity containing the moulding material (66), the closed intermediate cavity (95) being larger than the moulded part (66) and the first moulding surface (62) of the upper mould part (60) being spaced from the first major surface by a spacing distance, in the secondary phase air being at least partially evacuated from the closed intermediate cavity (95) while the first moulding surface (62) of the upper mould part (60) is spaced from the first major surface (68) to provide a vacuum pressure, and c. a tertiary closing phase after the vacuum pressure has been provided in the closed intermediate cavity (95), the tertiary phase having: I. a first stage prior to both the first moulding surface (62) contacting the first major surface (68) and the second moulding surface (64) contacting the second major ...

Thieno[2,3-c]pyrans as CFTR modulators

The present invention discloses compounds according to Formula I: Wherein R is as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment cystic fibrosis by administering a compound of the invention.

A methadone formulation for sublingual administration

A pharmaceutical composition for sublingual administration of methadone is described. The composition comprises methadone and ethanol. The composition may be useful for treating a human subject in need of an opioid. The composition may be useful for reducing pain, inducing or maintaining anaesthesia, or treating opioid dependence, anxiety, cough or diarrhoea in humans. Also described is the use of methadone and ethanol for the manufacture of medicament for a sublingual administration for treating a human subject in need of an opioid.

G-protein coupled receptor agonists

Urea and thiourea derivatives

The invention is directed to a new class of quinolin-2-one and chromen-2-one compounds that have been derivatized at the 6-position with a urea or thio urea moiety of formula (I) in which M, R1, R2, X and A are as defined in the claims, and to their use as androgen antagonists.

Tricyclo substituted amides

Compounds of Formula (I): (formula) or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.