Catalysts for metathesis reactions including enantioselective olefin metathesis, and related methods

The present invention provides compositions comprising metal complexes, and related methods. In some embodiments, metal complexes of the invention may be useful as catalysts for chemical reactions, including metathesis reactions, wherein the catalysts exhibit enhanced activity and stereoselectivity. In some embodiments, the invention may advantageously provide metal complexes comprising a stereogenic metal atom. Such metal complexes may be useful in enantioselective catalysis.

CATALYSTS FOR METATHESIS REACTIONS INCLUDING ENANTIOSELECTIVE OLEFIN METATHESIS, AND RELATED METHODS

The present invention provides compositions comprising metal complexes, and related methods. In some embodiments, metal complexes of the invention may be useful as catalysts for chemical reactions, including metathesis reactions, wherein the catalysts exhibit enhanced activity and stereoselectivity. In some embodiments, the invention may advantageously provide metal complexes comprising a stereogenic metal atom. Such metal complexes may be useful in enantioselective catalysis. 124-. (canceled)2631-. (canceled)32. The method of claim 25 , wherein the catalyzing occurs with an enantiomeric excess greater than 50%.3337-. (canceled)38. The method of claim 25 , wherein the catalyzing or reacting occurs with a yield of at least 50%.3947-. (canceled)48. The method of claim 25 , wherein the catalyst is present in the cross-metathesis reaction in an amount of 10 mol % or less.4980-. (canceled)81. The method of claim 25 , wherein the cross-metathesis reaction is conducted under an atmosphere of ethylene.8286-. (canceled)90. The method of claim 25 , wherein M is Mo.92. The method of claim 91 , wherein Rand Rare the same or different and are selected from the group consisting of F claim 91 , Cl claim 91 , Br claim 91 , or I.97. The method of claim 96 , wherein Rand Rare the same or different and are selected from the group consisting of F claim 96 , Cl claim 96 , Br claim 96 , or I.100. The method of claim 96 , wherein Rand Rare the same or different and are selected from the group consisting of F claim 96 , Cl claim 96 , Br claim 96 , or I.101. The method of claim 96 , wherein M is Mo. This application is a divisional of U.S. patent application Ser. No. 12/864,261, filed Oct. 12, 2010, and titled CATALYSTS FOR METATHESIS REACTIONS INCLUDING ENANTIOSELECTIVE OLEFIN METATHESIS, AND RELATED METHODS, now U.S. Pat. No. 9,687,834, which is a National Stage Entry of International Application No. PCT/US2009/000465, filed Jan. 23, 2009, and titled CATALYSTS FOR METATHESIS REACTIONS ...

Catalysts for metathesis reactions including enantioselective olefin metathesis, and related methods

The present invention provides compositions comprising metal complexes, and related methods. In some embodiments, metal complexes of the invention may be useful as catalysts for chemical reactions, including metathesis reactions, wherein the catalysts exhibit enhanced activity and stereoselectivity. In some embodiments, the invention may advantageously provide metal complexes comprising a stereogenic metal atom. Such metal complexes may be useful in enantioselective catalysis.

Complexes for use in metathesis reactions

The present invention relates generally to metal complexes, methods for preparation and uses of the same.

Efficient methods for Z- or cis-selective cross-metathesis

The present invention generally relates to methods for performing metathesis reactions, including cross-metathesis reactions. Methods described herein exhibit enhanced activity and stereoselectivity, relative to known methods, and are useful in the synthesis of a large assortment of biologically and therapeutically significant agents.

Catalysts for metathesis reactions including enantioselective olefin metathesis, and related methods

The present invention provides compositions comprising metal complexes, and related methods. In some embodiments, metal complexes of the invention may be useful as catalysts for chemical reactions, including metathesis reactions, wherein the catalysts exhibit enhanced activity and stereoselectivity. In some embodiments, the invention may advantageously provide metal complexes comprising a stereogenic metal atom. Such metal complexes may be useful in enantioselective catalysis.

Catalizadores para reacciones de metatesis incluyendo metatesis de olefina enantioselectiva, y metodos relacionados.

La presente invención proporciona composiciones que comprenden complejos metálicos, y métodos relacionados. En algunas modalidades, los complejos metálicos de la invención pueden ser útiles para reacciones químicas, incluyendo reacciones de metátesis, en donde los catalizadores exhiben actividad y estereoselectividad mejoradas. En algunas modalidades, la invención ventajosamente puede proporcionar complejos metálicos comprendiendo un átomo metálico estereogénico. Dichos complejos metálicos pueden ser útiles en catálisis enantioselectiva.

Efficient methods for z- or cis-selective cross-metathesis

Catalysts for metathesis reactons including enantioselective olefin metathesis, and related methods

The present invention provides compositions comprising metal complexes, and related methods. In some embodiments, metal complexes of the invention may be useful as catalysts for chemical reactions, including metathesis reactions, wherein the catalysts exhibit enhanced activity and stereoselectivity. In some embodiments, the invention may advantageously provide metal complexes comprising a stereogenic metal atom. Such metal complexes may be useful in enantioselective catalysis.

Catalysts for metathesis reactions including enantioselective olefin metathesis, and related methods

The present invention provides compositions comprising metal complexes, and related methods. In some embodiments, metal complexes of the invention may be useful as catalysts for chemical reactions, including metathesis reactions, wherein the catalysts exhibit enhanced activity and stereoselectivity. In some embodiments, the invention may advantageously provide metal complexes comprising a stereogenic metal atom. Such metal complexes may be useful in enantioselective catalysis.

catalysts for metathesis reactions including enantioselective olefin metathesis, and related methods

Catalysts for metathesis reactions including enantioselective olefin metathesis, and related methods

The present invention provides compositions comprising metal complexes, and related methods. In some embodiments, metal complexes of the invention may be useful as catalysts for chemical reactions, including metathesis reactions, wherein the catalysts exhibit enhanced activity and stereoselectivity. In some embodiments, the invention may advantageously provide metal complexes comprising a stereogenic metal atom. Such metal complexes may be useful in enantioselective catalysis.