Production of erythropoietin by endogenous gene activation

The invention relates to human cells which are capable, on the basis of an activation of the endogenous human EPO gene, of producing EPO in a sufficient amount and purity to make possible a cost-effective production of human EPO as a pharmaceutical preparation. The invention furthermore relates to a method for the preparation of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO inhuman cells, and a method for the large technical production of EPO in human cells.

Preparation of erythropoietin by endogenous gene activation

The invention relates to human cells which are capable, on the basis of an activation of the endogenous human EPO gene, of producing EPO in a sufficient amount and purity to make possible a cost-effective production of human EPO as a pharmaceutical preparation. The invention furthermore relates to a method for the preparation of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO in human cells, and a method for the large technical production of EPO in human cells.

Processing apparatus for packaging machines

The invention relates to a processing apparatus for packaging machines having at least one upper processing unit for processing upper package sides and at least one lower processing unit for processing lower package sides, and having a common adjustment axle for the processing units along which the processing units are adjustable manually or by means of a drive in an adjustment direction that extends in parallel with a direction of transport of the packaging machine.

Monoclonal anti-IL-1RAcp antibodies

Monoclonal antibody that specifically binds IL-1RAcP, or an antigen binding fragment thereof, comprising: a) a heavy chain variable region (VH) comprising CDR1H, CDR2H and/or CDR3H, wherein the CDR1H region comprises an amino acid sequence selected from the group of SEQ ID NO: 155-231, wherein the CDR2H region comprises an amino acid sequence selected from the group of SEQ ID NO: 232-308, and wherein the CDR3H region comprises an amino acid sequence selected from the group of SEQ ID NO: 309-385; and b) a light chain variable region (VL) comprising CDR1L, CDR2L and/or CDR3L, wherein the CDR1L region comprises an amino acid sequence selected from the group of SEQ ID NO: 386-462, wherein the CDRL2 region comprises an amino acid sequence selected from the group of SEQ ID NO: 463-539, and wherein the CDR3L region comprises an amino acid sequence selected from the group of SEQ ID NO: 540-616 The monoclonal antibody is characterized in that it inhibits IL-1RAcP induced NFkB activity, useful in ...

Production of erythropoietin by endogenous gene activation

Control System for Mining Machine

A mining machine such as a mining shovel includes a digging assembly having an upward extending boom and a dipper assembly with a dipper that is generally horizontally supported by the boom. A hoist system including hoist ropes attached to the dipper may be used to vertically pivot the dipper assembly with respect to the boom. To determine if the hoist ropes are properly supporting the weight of the dipper assembly, an electronic controller can calculate a calculated hoist force based on a hoist speed associated with the hoist ropes and a hoist motor torque from a hoist motor. If the calculated hoist force indicates that slack exists in the hoist ropes, the electronic controller can execute a slack reduction function to increase tension in the hoist ropes attached to the dipper. 1. A mining machine comprising:an undercarriage; a digging assembly disposed on the upper structure, the digging assembly including:', 'a boom connected to the upper structure at a lower end and extending upwardly to an upper end;', 'a dipper assembly including a dipper arm and a dipper disposed at a first end of the dipper arm, the dipper assembly pivotally supported by the boom;', a hoist motor disposed on the upper structure;', 'a hoist rope operatively associated with the hoist motor and running from a hoist winch upwards about the upper end of the boom and downwards to attach to the dipper;, 'a hoist system for pivoting the dipper assembly with respect to the boom in a generally vertical direction, the hoist system including], 'an upper structure supported on the undercarriage;'}an electronic controller operatively associated with the hoist system and in electronic communication with hoist motor, the electronic controller configured to receive a hoist speed and an hoist motor torque and to determine a calculated hoist rope force indicative of tension in the hoist rope based in part on the hoist speed and the hoist motor torque.2. The mining machine of claim 1 , wherein the electronic ...

Antibodies against CCR5 and uses thereof

Antibodies that specifically bind to CCR5 are useful for treating immunosuppressive disease.

Preparation of erythropoietin by endogenous gene activation

The invention relates to human cells which are capable, on the basis of an activation of the endogenous human EPO gene, of producing EPO in a sufficient amount and purity to make possible a cost-effective production of human EPO as a pharmaceutical preparation. The invention furthermore relates to a method for the preparation of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO in human cells, and a method for the large technical production of EPO in human cells.

Pharmaceutical compositions for intranasal administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] phosphonic acid and derivatives and methods of use thereof

Pharmaceutical compositions for intranasal administration are provided that contain at least one compound of formula (I) or a pharmaceutically acceptable salt thereof: and one or more pharmaceutically acceptable additives for forming a composition for intranasal administration. Also provided are methods of treating one or more conditions in a mammal associated with a glutamate abnormality that includes administering intranasally to a mammal a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof.

Production of erythropoietin by endogenous gene activation

2-(2,6-dichlorophenyl)-diarylimidazoles

The invention is directed to compounds of formula (I), which are valuable therapeutics for the treatment of cancer and related diseases.

Packaging snack food chips

Chips 2 are in a sequentially overlapping row 6 on an elongate support 4; the row and support are inserted into an elongate container 18 having a closed end 20; the elongate support is vibrated 24; the closed end of the container is moved away from an adjacent end of the support. Before the container finishes moving away from the support, the support and container are simultaneously rotated so that the closed end descends and the chips row/stack becomes more vertical. Ideally the chips fall under gravity to form a vertical stack. The support can be a concave chute. Ideally the vibration has smaller amplitude than the chip spacings and align with the direction of the support. The support can hold a measured dose of chips. A closure can then be applied to the packages open end. The chips can be curved equilateral triangles with the straight edge leading.

PEG conjugates of NK4

The present invention provides a conjugate consisting essentially of a NK4 molecule and a polyethylene glycol group having a molecular weight of from about 20 to about 40 kDa. The invention also provides a composition in which the monoPEGylated conjugates comprise at least 90% of the total of pegylated NK4 molecules and unpegylated NK4 molecules in the composition. Also provided is a composition in which the monoPEGylated conjugates comprise conjugates in which the PEG groups are attached to groups randomly selected from the lysine side chains of NK4 molecules and the N-terminal amino groups of NK4 molecules. A method for the treatment of cancer by administering 1 to 30 mg monoPEGylated NK4 per kg per day is further provided.

Handling snack food chips

Aligned chips 2 have convex face down and concave face up; they move along a conveyor 4; they transfer onto a concave surface 20 of an inverter 14 which contacts their concave face; the concave surface 20 moves down; the chips 2 are deposited on another conveyor 34 below the concave surface with their concave face downward. Ideally the conveyors and inverters are belts, the first conveyor can be formed of multiple narrow loops with each chip resting on two. The concave inverter belt can include grooved channels to guide the chips. There may be a third belt 40 and the first conveyor belt and inverter moves faster than subsequent belt(s) so that chips are brought closer and become shingled 44. The second conveyor may slope upwards. The second conveyor may rotate in substantially the same direction as the first conveyor but opposite to the part of the inverting conveyor nearest the second conveyor. The concave surface can be substantially semi-circular. There can be a provision for seasoning ...

Identification of human cell lines for the production of human proteins by endogenous gene activation

Packaging snack food chips

Method of and apparatus for packaging snack food chips

A method of packaging snack food chips, the method comprising the steps of: (a) providing a plurality of snack food chips as a shingled assembly of the snack food chips; (b) enclosing the shingled assembly within an elongate packaging container; (c) vibrating the shingled assembly supported so as to cause the snack food chips sequentially to fall from a free output end into the elongate packaging container while progressively translationally separating a closed end and the free output end to form a shingled stack extending away from the closed end; and (d) during at least a part of step (c), rotating the elongate packaging container so that the closed end is lowered while decreasing an angle of inclination such that the shingled stack is being progressively formed.

Conjugate of an antibody against CCR5 and an antifusogenic peptide

The current invention is related to a conjugate comprising one or more antifusogenic peptides and an anti-CCR5 antibody (mAb CCR5) characterized in that one to eight antifusogenic peptides are each conjugated to one terminus of the heavy and/or light chains of said anti-CCR5 antibody and to the pharmaceutical use of said conjugate.

MONOCLONAL ANTI-IL-1RACP ANTIBODIES

Monoclonal antibody that specifically binds IL-1RAcP, or an antigen binding fragment thereof, comprising: 136-. (canceled)37. A monoclonal antibody that specifically binds to human IL-1RAcP , wherein the monoclonal antibody is capable of inhibiting IL-1 alpha , IL-1 beta , IL-33 , and IL-36 stimulated NFκB activity.38. The monoclonal antibody of claim 37 , capable of binding to murine IL-1RAcP.39. The monoclonal antibody of claim 37 , capable of inhibiting murine IL-1RAcP induced murine NFκB activity.40. The monoclonal antibody of claim 37 , capable of inhibiting NFκKB activity stimulated by a complex selected from the group consisting of IL-1β/IL-1R1/IL-1RAcP claim 37 , IL-1α/IL-1R1/IL-1RAcP claim 37 , IL-33/ST2/IL-1RAcP claim 37 , and/or IL-36 / IL-36R/IL-1RAcP.41. The monoclonal antibody of claim 37 , wherein ADCC activity is reduced by at least 20% relative to an antibody comprising a wild-type human IgG1 Fc region.42. The monoclonal antibody of claim 37 , comprising reduced affinity to the human FcγRIIIA claim 37 , FcγRIIA claim 37 , and/or FcγRI relative to an antibody comprising a wild-type human IgG1 Fc region.43. The monoclonal antibody of claim 37 , comprising amino acid substitutions at L234A and L235A of the human IgG1 Fc region claim 37 , or S228P and L235E of the human IgG4 Fc region.44. The monoclonal antibody of claim 37 , comprising a heavy chain variable (VH) region that is at least 90% identical to a VH region selected from the group consisting of VH regions of SEQ ID NOs: 1 to 77.45. The monoclonal antibody of claim 37 , comprising a light chain variable (VL) region that is at least 90% identical to a VL region selected from the group consisting of VL regions of SEQ ID NOs: 78 to 154.46. The monoclonal antibody of claim 37 , comprising a VH region that is at least 90% identical to a VH region of SEQ ID NO: 1+n claim 37 , and comprising a VL region that is at least 90% identical to a VL region of SEQ ID NO: 78+n claim 37 , wherein n is a number ...

Control System for a Rotating Machine

A system for controlling movement of a work implement of a machine between a dump location and a plurality of dig locations includes a rotatable implement system, and an implement system pose sensor. A controller is configured to store first dig signals from the implement system pose sensor indicative of a first dig location, store second dig signals from the implement system pose sensor indicative of a second dig location spaced from the first dig location and store a dump location. The controller is further configured to generate command signals to move the work implement from the first dig location to the dump location, generate command signals to dump a load of material carried by the work implement at the dump location, and generate command signals to move the work implement from the dump location to the second dig location. 1. A system for controlling movement of a work implement of a machine between a dump location and a plurality of dig locations , comprising:a rotatable implement system at a work site having a linkage assembly including the work implement;an implement system pose sensor for generating implement system pose signals indicative of a pose of the implement system including a pose of the work implement; anda controller configured to:store first dig signals from the implement system pose sensor indicative of a first dig location;store second dig signals from the implement system pose sensor indicative of a second dig location, the second dig location being spaced from the first dig location;store a dump location;generate command signals to move the work implement from the first dig location to the dump location;generate command signals to dump a load of material carried by the work implement at the dump location; andgenerate command signals to move the work implement from the dump location to the second dig location.2. The system of claim 1 , wherein the controller is further configured to store the first dig signals based upon positioning of the ...

Sharing content in a messaging application

A device implementing a system for sharing groups of files within a messaging application includes a processor configured to provide, within the messaging application, a user interface element for sending at least one file to a participant in an active message thread of the messaging application, the at least one file having been determined to be relevant to the participant. The processor is further configured to, responsive to receiving a selection of the user interface element: transmit, to a server, a request to store the at least one file in association with a shared storage area, and to transmit, via the messaging application, a message to the participant in the active message thread, the message comprising information for accessing the at least one file associated with the shared storage area.

Identity crowd-sourced curation

A method includes gathering a plurality of instances of online activity associated with a user, analyzing the plurality of instances of online activity to determine a characteristic that is likely to correspond to a profile attribute of the user and generating a profile enrichment suggestion for the user based on the determined characteristic.

User interfaces for sharing contextually relevant media content

The present disclosure generally relates to managing and sharing contextually-relevant media content. In some embodiments, a device receives an input, and in response, displays a suggested collection of media items for sharing with a recipient, wherein the collection is relevant to a message conversation with the recipient. Subsequent to displaying the suggested collection, the device transmits a message to the recipient as part of the message conversation that provides access to the at least a portion of the suggested collection of media items. In some embodiments, a device receives an indication, from an external device, that a first user has shared a first collection of media items with a second user. Subsequent to receiving the indication that the first user has shared the first collection of media items with the second user, the device outputs a prompt to share, with the first user, one or more suggested media items.

CONJUGATE OF AN ANTIBODY AGAINST CCR5 AND AN ANTIFUSOGENIC PEPTIDE

The current invention is related to a conjugate comprising one or more antifusogenic peptides and an anti-CCR5 antibody (mAb CCR5) characterized in that one to eight antifusogenic peptides are each conjugated to one terminus of the heavy and/or light chains of said anti-CCR5 antibody and to the pharmaceutical use of said conjugate.

Methods for identifying human cell lines useful for endogenous gene activation isolated human cell lines identified thereby, and uses thereof

The invention concerns human cells which, due to an activation of the endogenous human EPO gene, are able to produce EPO in an adequate quantity and purity to enable a cost-effective production of human EPO as a pharmaceutical preparation. Furthermore the invention concerns a process for the production of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO gene in human cells as well as a process for the large-scale production of EPO in human cells.

PEG conjugates of NK4

The present invention provides a conjugate consisting essentially of a NK4 molecule and a polyethylene glycol group having a molecular weight of from about 20 to about 40 kDa. The invention also provides a composition in which the monoPEGylated conjugates comprise at least 90% of the total of pegylated NK4 molecules and unpegylated NK4 molecules in the composition. Also provided is a composition in which the monoPEGylated conjugates comprise conjugates in which the PEG groups are attached to groups randomly selected from the lysine side chains of NK4 molecules and the N-terminal amino groups of NK4 molecules. A method for the treatment of cancer by administering 1 to 30 mg monoPEGylated NK4 per kg per day is further provided.

Methods and systems for interactive data input

Described herein are methods and systems to generate and display interactive graphical user interfaces that receive data inputs from users while emulating a chat session. A server retrieves a set of prompts associated with an electronic form; displays, within a webpage, a first element corresponding to a prompt and a second element having at least one input element configured to receive an input from a user interacting with the webpage. When the user interacts with an input element, the server relocates the first element and dynamically revises the second element by relocating the second element and displaying inputted values received from the user interacting with the at least one input element of the second element. The server then displays a third element comprising next prompts of the electronic form.

HER-2 binding antibodies

The present invention relates to monoclonal antibodies that specifically bind to HER2, or a fragment or derivative thereof or a polypeptide that contains at least a portion of said antibody that is sufficient to confer specific HER2 binding to the polypeptide. Said antibodies bind to the human Fc receptor and induce FcR mediated signaling pathways. The antibodies according to the invention bind to a different epitope than trastuzumab. The invention also relates to the use of an antibody according to the invention in the treatment of a HER-2 mediated disease. The present invention also relates to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of the antibody according to the invention, and the use of said composition in the treatment of a HER-2 mediated disease.

HUMANIZED ANTI-IL-1R3 ANTIBODIES

The present invention relates to humanized antibodies that specifically bind to IL-1R3 or a fragment or derivative thereof or a polypeptide that contains at least a portion of said antibody that is sufficient to confer IL-1R3 binding specificity. Said antibodies inhibit IL-1R3 induced NFkB activity. They also inhibit IL-1alpha, IL-1beta, IL-33, and/or IL-36 stimulated NFkB activity.The invention further relates to use of said humanized antibody in the treatment of an IL-1R3 mediated disease such as cancer.The present invention also encompasses a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of the antibody according to the invention. The pharmaceutical composition can be used in treating a IL-1R3 mediated disease such as cancer.

Identification of human cell lines for the production of human proteins by endogenous gene activation

A process for selecting human cells for the production of human proteins by endogenous gene activation allows human proteins to be produced in economically feasible quantities and in a form suitable for producing a pharmaceutical composition. Also disclosed is a process for producing human proteins in a cell line identified in this matter.

TRACKING REGULATOR SYSTEM AND METHOD FOR PROCESSING COLUMNS

A processing column system includes an inlet, an outlet, a piston head and a piston pressure chamber for providing a controlled bed pressure to the piston head and thus to a substrate and/or liquid bed positioned within the column. A tracking regulator is in fluid communication with a source of pressurized hydraulic fluid and the piston pressure chamber as well as the inlet to the column. The tracking regulator receives a pressure of a process fluid flow into the processing column. The tracking regulator has a hydraulic fluid drain port in fluid communication with the source of pressurized hydraulic fluid. The tracking regulator directs hydraulic fluid from the piston pressure chamber to the source of pressurized hydraulic fluid when the tracking regulator detects a drop in the pressure of the process fluid flow. The source of pressurized hydraulic fluid provides to the tracking regulator a pressure equal to a set bed pressure of the system plus a maximum anticipated process flow pressure ...

Systems and methods for improving patient access to medical therapies

The system and method utilizes a computer system having processors that receive quantitative data from users and generate data to facilitate prioritization and reduction of barriers that prevent patients from receiving medical therapies from a particular healthcare provider in rank order. The processors provide an initial rank order of potential barriers based on calculated correlation coefficient, and determine a subsequent rank order of potential barriers based on the calculated correlation coefficient and other data indicative of the effect of each barrier on the patients. The system and method provides for a systematic, data-driven, and validated process to improve patient access to healthcare providers.

Humanized anti-IL-1R3 antibodies

The present disclosure relates to humanized antibodies that specifically bind to IL-1R3 or a fragment or derivative thereof or a polypeptide that contains at least a portion of said antibody that is sufficient to confer IL-1R3 binding specificity. Said antibodies inhibit IL-1R3 induced NFkB activity. They also inhibit IL-1alpha, IL-1beta, IL-33, and/or IL-36 stimulated NFkB activity. The disclosure further relates to use of said humanized antibody in the treatment of an IL-1R3 mediated disease such as cancer. The disclosure finally encompasses a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of the antibody according to the invention. The pharmaceutical composition can be used in treating a IL-1R3 mediated disease such as cancer.

IDENTITY CROWD-SOURCED CURATION

A method includes gathering a plurality of instances of online activity associated with a user, analyzing the plurality of instances of online activity to determine a characteristic that is likely to correspond to a profile attribute of the user and generating a profile enrichment suggestion for the user based on the determined characteristic. 1. A computer-implemented method comprising:gathering a plurality of instances of online activity associated with a user;analyzing the plurality of instances of online activity to determine a characteristic that is likely to correspond to a profile attribute of the user; andgenerating a profile enrichment suggestion for the user based on the determined characteristic.2. The computer-implemented method of claim 1 , further comprising:determining a contact associated with the user for making the generated suggestion to the user; andproviding the generated suggestion to the determined contact for sending to the user.3. The computer-implemented method of claim 1 , wherein the profile enrichment suggestion is generated for the user in response to a request for the profile enrichment suggestion received from a contact associated with the user.4. The computer-implemented method of claim 3 , further comprising:providing the generated suggestion to the contact associated with the user for sending to the user.5. The computer-implemented method of claim 1 , where the profile enrichment suggestion is generated for the user in response to a request for the profile enrichment suggestion received from the user.6. The computer-implemented method of claim 5 , further comprising:providing the generated suggestion to the user.7. The computer-implemented method of claim 1 , further comprising:identifying the user for receiving the profile enrichment suggestion.8. The computer-implemented method of claim 7 , further comprising:determining that the user is a candidate for receiving the profile enrichment suggestion.9. The computer-implemented ...

Aircraft seat with roller ball-assisted motion

An adjustable chair is disclosed which can be used in aircraft, motor homes, or the like. In an embodiment, the chair includes a seat mounted on a base such that the weight of the seat rests on roller ball assemblies disposed on a top surface of the base. The roller ball assemblies advantageously reduce friction between the seat and the base and improve translational and rotational adjustment of the seat.

Treatment of pain

This invention provides a method of treating pain in a mammal that includes administering to a mammal in need of such treatment a pain treating effective amount of a compound of the formula I: or a pharmaceutically acceptable salt thereof, wherein each of R1, R2, R3, n, y, and Ar is as defined and described herein. The present invention also provides pharmaceutical compositions for treating pain containing a pain treating effective amount of the compound of formula I.

MONOCLONAL ANTI-IL-1RACP ANTIBODIES

Monoclonal antibody that specifically binds IL-1RAcP, or an antigen binding fragment thereof, comprising: 136.-. (canceled)37. A monoclonal antibody that specifically binds to human IL-1RAcP , wherein the monoclonal antibody is capable of inhibiting IL-1 alpha , IL-1 beta , IL-33 , and IL-36 stimulated NFκB activity.38. The monoclonal antibody of claim 37 , capable of binding to murine IL-1RAcP.39. The monoclonal antibody of claim 37 , capable of inhibiting murine IL-1RAcP induced murine NFκB activity.40. The monoclonal antibody of claim 37 , capable of inhibiting NFκB activity stimulated by a complex selected from the group consisting of IL-1β/IL-1R1/IL-1RAcP claim 37 , IL-1α/IL-1R1/IL-1RAcP claim 37 , IL-33/ST2/IL-1RAcP claim 37 , and/or IL-36/IL-36R/IL-1RAcP.41. The monoclonal antibody of claim 37 , capable of inhibiting NFκB activity by 70% or more at a concentration of 5 μg/mL in 293T/17 cell lysates stimulated with 0.5 μg/mL human IL-1 alpha claim 37 , IL-1 beta claim 37 , IL-33 claim 37 , and/or IL-36 claim 37 , relative to the same assay without the monoclonal antibody.42. The monoclonal antibody of claim 37 , capable of inhibiting NFκB activity by 70% or more at a concentration of 5 μg/mL in mouse cell line lysates stimulated with 0.5 μg/mL murine IL-1 alpha claim 37 , IL-1 beta claim 37 , IL-33 claim 37 , and/or IL-36 claim 37 , relative to the same assay without the monoclonal antibody.43. The monoclonal antibody of claim 37 , capable of inhibiting IL-1 alpha claim 37 , IL-1 beta claim 37 , IL-33 claim 37 , and/or IL-36 stimulated luciferase activity in 293T/17 cells claim 37 , wherein luciferase expression is under control of an NFκB reporter gene.44. The monoclonal antibody of claim 37 , wherein ADCC activity is reduced by at least 20% relative to an antibody comprising a wild-type human IgG1 Fc region.45. The monoclonal antibody of claim 37 , comprising reduced affinity to the human FcγRIIIA claim 37 , FcγRIIA claim 37 , and/or FcγRI relative to an ...

Humanized Anti-IL-1R3 Antibodies

The present disclosure relates to humanized antibodies that specifically bind to IL-1R3 or a fragment or derivative thereof or a polypeptide that contains at least a portion of said antibody that is sufficient to confer IL-1R3 binding specificity. Said antibodies inhibit IL-1R3 induced NFkB activity. They also inhibit IL-1alpha, IL-1beta, IL-33, and/or IL-36 stimulated NFkB activity. The disclosure further relates to use of said humanized antibody in the treatment of an IL-1R3 mediated disease such as cancer. The disclosure finally encompasses a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of the antibody according to the invention. The pharmaceutical composition can be used in treating a IL-1R3 mediated disease such as cancer. 1. Humanized antibody that specifically binds to IL-1R3 or a fragment or derivative thereof that contains at least a portion of said antibody that is sufficient to confer IL-1R3 binding specificity , comprising:a) a heavy chain variable region (VH) comprising the complementary determining regions comprising CDR-H1, CDR-H2, and CDR-H3wherein the CDR-H1 region comprises an amino acid sequence selected from the group of SEQ ID NO: 69-85,wherein the CDR-H2 region comprises an amino acid sequence selected from the group of SEQ ID NO: 86-102,and wherein the CDR-H3 region comprises an amino acid sequence selected from the group of SEQ ID NO: 103-119; andb) a light chain variable region (VL) comprising the complementary determining regions comprising CDR-L1, CDR-L2, and CDR-L3wherein the CDR-L1 region comprises an amino acid sequence selected from the group of SEQ ID NO: 120-136,wherein the CDR-L2 region comprises an amino acid sequence selected from the group of SEQ ID NO: 137-153, andwherein the CDR-L3 region comprises an amino acid sequence selected from the group of SEQ ID NO: 154-170, and SEQ ID NO: 175.2. Humanized antibody that specifically binds to IL-1R3 or a fragment or ...

Control System for Mining Machine

A mining machine such as a mining shovel includes a digging assembly having an upward extending boom and a dipper arm generally horizontally supported by the boom. The dipper assembly includes a dipper disposed at one end of a dipper arm that can slide in translation with respect to the boom to crowd toward or retract from a vertical bank at the mining site. To translate the dipper assembly, the mining machine includes a crowd system having a crowd motor and a crowd actuator. An electronic controller receives the crowd motor torque, a crowd speed of the dipper assembly, and an inertia parameter associated with the dipper assembly. The electronic controller can determine an approximate location of the dipper with respect to the bank and, in a further aspect, can execute an anti-swing function if the dipper is in the bank. 1. A mining machine comprising:an undercarriage;an upper structure rotatably supported to swing with respect to the undercarriage; a boom connected to the upper structure at a lower end and extending upwardly to an upper end;', 'a dipper assembly including a dipper arm and a dipper disposed at a first end of the dipper arm, the dipper assembly slidably supported by the boom;', a crowd motor disposed in the upper structure,', 'a crowd actuator operatively associated with the crowd motor and arranged to slide the dipper arm with respect to the boom; and, 'a crowd system for slidably moving the dipper assembly with respect to the boom in a crowd direction and in a retract direction, the crowd system including], 'a digging assembly disposed on the upper structure, the digging assembly includingan electronic controller operatively associated with the crowd system and in electronic communication with the crowd motor, the electronic controller configured to receive a crowd speed and a crowd motor torque and to calculate a calculated crowd force and to determine an approximate location of the dipper based on the calculated crowd force.2. The mining machine ...

Methods for identifying human cell lines useful for endogenous gene activation, isolated human cell lines identified thereby, and uses thereof

The invention concerns human cells which, due to an activation of the endogenous human EPO gene, are able to produce EPO in an adequate quantity and purity to enable a cost-effective production of human EPO as a pharmaceutical preparation. Furthermore the invention concerns a process for the production of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO gene in human cells as well as a process for the large-scale production of EPO in human cells.

Monoclonal anti-IL-1RAcP antibodies

Monoclonal antibody that specifically binds the interleukin 1 receptor type 1 (IL-1RAcP), or an antigen binding fragment thereof, comprising: a) a heavy chain variable region (VH) comprising CDR1H, CDR2H and/or CDR3H, wherein the CDR1H region comprises an amino acid sequence selected from the group of SEQ ID NO: 155-231, wherein the CDR2H region comprises an amino acid sequence selected from the group of SEQ ID NO: 232-308, and wherein the CDR3H region comprises an amino acid sequence selected from the group of SEQ ID NO: 309-385; and b) a light chain variable region (VL) comprising CDR1L, CDR2L and/or CDR3L, wherein the CDR1L region comprises an amino acid sequence selected from the group of SEQ ID NO: 386-462, wherein the CDRL2 region comprises an amino acid sequence selected from the group of SEQ ID NO: 463-539, and wherein the CDR3L region comprises an amino acid sequence selected from the group of SEQ ID NO: 540-616. The monoclonal antibody is characterized in that it inhibits IL-1RAcP ...

Package for data medium

HER-2 Binding Antibodies

The present invention relates to monoclonal antibodies that specifically bind to HER2, or a fragment or derivative thereof or a polypeptide that contains at least a portion of said antibody that is sufficient to confer specific HER2 binding to the polypeptide. Said antibodies bind to the human Fc receptor and induce FcR mediated signaling pathways. The antibodies according to the invention bind to a different epitope than trastuzumab. The invention also relates to the use of an antibody according to the invention in the treatment of a HER-2 mediated disease. The present invention also relates to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of the antibody according to the invention, and the use of said composition in the treatment of a HER-2 mediated disease.

Afucosylated antibodies against CCR5 and their use for the treatment of inflammatory conditions

An antibody binding to CCR5 and being glycosylated with a sugar chain at Asn297, said antibody being characterized in that the amount of fucose within said sugar chain is 65% or lower has improved properties in anti-inflammatory therapy.

Scatter factor/hepatocyte growth factor antagonist NK4 for the treatment of glioma

A pharmaceutical composition for the treatment of a tumor derived from glia cells of the central nervous system (CNS) of a patient, characterized in that the composition contains a pharmaceutically acceptable amount of a fragment of the hepatocyte growth factor, the fragment consisting of the N-terminal hairpin domain and the four kringle domains of the hepatocyte growth factor α-chain.

SYSTEMS AND METHODS FOR IMPROVING PATIENT ACCESS TO MEDICAL THERAPIES

The system and method utilizes a computer system having processors that receive quantitative data from users and generate data to facilitate prioritization and reduction of barriers that prevent patients from receiving medical therapies from a particular healthcare provider in rank order. The processors provide an initial rank order of potential barriers based on calculated correlation coefficient, and determine a subsequent rank order of potential barriers based on the calculated correlation coefficient and other data indicative of the effect of each barrier on the patients. The system and method provides for a systematic, data-driven, and validated process to improve patient access to healthcare providers. 1. A system , comprising:one or more processors configured to provide an initial barrier prioritization rank order of one or more barriers wherein the initial barrier prioritization rank order is based on a correlation coefficient calculated for each of the one or more barriers;the one or more processors configured to receive data indicative of the one or more barriers preventing patients from receiving a medical therapy from a healthcare provider; andthe one or more processors determining a subsequent barrier prioritization rank order using the initial barrier prioritization rank order based on the received data indicative of the one or more barriers preventing patients from receiving a medical therapy from a healthcare provider.2. The system of claim 1 , wherein the correlation coefficient is calculated for each barrier with respect to an annual adoption rate.3. The system of claim 1 , wherein the data indicative of the one or more barriers preventing patients from receiving a medical therapy from a healthcare provider is obtained from a scaled response to a multiple choice question claim 1 , wherein the scaled response is used to determine the subsequent barrier prioritization rank order.4. The system of claim 1 , wherein the one or more processors is ...

HIGH STRENGTH, HIGH STRESS CORROSION CRACKING RESISTANT AND CASTABLE Al-Zn-Mg-Cu-Zr ALLOY FOR SHAPE CAST PRODUCTS

The present invention provides an AlZnMgCu casting alloy that provides high strength for automotive and aerospace applications and optimized stress corrosion cracking resistance in highly corrosive and tensile environments. The inventive alloy composition includes about 3.5 wt. % to about 5.5 wt. % Zn; about 1.0 wt. % to about 3.0 wt. % Mg; about 0.5 wt. % to about 1.2 wt. % Cu; less than about 1.0 wt. % Si; less than about 0.30 wt. % Mn; less than about 0.30 wt. % Fe; and a balance of Al and incidental impurities.

Control System for a Rotating Machine

A system for evaluating a position of a target zone relative to a path of a material engaging work implement includes a rotatable implement system, an implement system pose sensor, and a target pose sensor. A controller determines a current pose of a portion of the implement system, determines a first pose of the target zone, determines a plurality of potential paths for moving the work implement to the first pose, and generates an alert command if a kinematic model and desired operating characteristics do not permit movement of the work implement to the first pose. 1. A system for evaluating a position of a target zone relative to a path of a material engaging work implement comprising:a rotatable implement system at a work site, the implement system having a linkage assembly including the work implement;an implement system pose sensor for generating implement system pose signals indicative of a pose of a portion of the implement system;a haul truck having the target zone, the target haul truck being movable at the work site;a target pose sensor for generating target pose signals indicative of a pose of the target zone; and store a kinematic model and desired operating characteristics of the implement system;', 'determine a current pose of the portion of the implement system based upon the implement system pose signals;', 'determine a first pose of the target zone based upon the target pose signals;', 'determine that no potential paths exist for moving the work implement to the first pose of the target zone based upon the current pose of the portion of the implement system and the kinematic model and the desired operating characteristics of the implement system; and', 'upon determining that the current pose of the portion of the implement system and the kinematic model and the desired operating characteristics do not permit movement of the work implement to the first pose of the target zone along any potential paths to the first pose of the target zone, transmit re ...

Packaging machine for producing packaging comprising a transponder

The invention relates to a packaging machine for packing food products in a plastic packaging, said machine comprising a device for applying a transponder to the plastic packaging, and a system for data exchange between the transponder and a computer unit and/or a regulating unit, by which means data can be transmitted to the transponder or called therefrom.

Processing arrangement and method for conditioning a processing arrangement

A processing arrangement comprising: a process chamber comprising an upper chamber wall, a lower chamber wall and two lateral chamber walls; an insulating structure, arranged between the processing region and each of the upper chamber wall, the lower chamber wall and the two lateral chamber walls, respectively, for thermally insulating the processing region, wherein the insulating structure is configured as gas-permeable at least in sections in such a way that a process gas from the processing region can flow out of the processing region in the direction in each of the upper chamber wall, the lower chamber wall and the two lateral chamber walls, respectively, through the insulating structure; and a gas channel, arranged between the insulating structure and each of the upper chamber wall, the lower chamber wall and the two lateral chamber walls, respectively, for pumping away the process gas which flows through the insulating structure.

[[2-(Amino-3,4-dioxo-1-cyclobuten-1-yl)amino]alkyl]-acid derivatives for the treatment of pain

This invention provides a method of treating pain in a mammal that includes administering to a mammal in need of such treatment a pain treating effective amount of a compound of the formula (I): where R1is H, alkyl or phenylalkyl; R2is H, alkyl, alkenyl or phenylalkyl; or R1and R2taken together as Z are —CH2C—H2—, —CH2C(R6)(R7)CH2— or —CH2C(R8)(R9)—C(R10)(R11)CH2—, where R6, R8and R10are, independently, H, alkyl or hydroxyl and R7, R9and R11are, independently, H or alkyl; A is alkylene or alkenylene; X is CO2R3, P(O)(OR4)(OR5), 3,5-dioxo-1,2,4-oxadiazolidin-2-yl or 5-tetrazolyl in which R3, R4and R5are, independently, H or alkyl, or a pharmaceutically acceptable salt thereof. The present invention also provides pharmaceutical compositions for treating pain containing a pain treating effective amount of the compound of formula (I).

Methods for identifying human cell lines useful for endogenous gene activation, isolated human lines identified thereby, and uses thereof

The invention concerns human cells which, due to an activation of the endogenous human EPO gene, are able to produce EPO in an adequate quantity and purity to enable a cost-effective production of human EPO as a pharmaceutical preparation. Furthermore the invention concerns a process for the production of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO gene in human cells as well as a process for the large-scale production of EPO in human cells.

Identification of human cell lines for the production of human proteins by endogenous gene activation

A process for selecting human cells for the production of human proteins by endogenous gene activation allows human proteins to be produced in economically feasible quantities and in a form suitable for producing a pharmaceutical composition. Also disclosed is a process for producing human proteins in a cell line identified in this matter.

System and method for compensating binary inlet buffers during inline buffer diluation

Liquid blending systems and methods of blending liquids are provided. In particular, systems and methods for compensating binary inlet buffers during inline buffer dilution are provided. The systems and methods can provide blends of diluent, a first buffer concentrate containing a majority of a tempering component, and a second buffer concentrate containing a minority of a tempering component. The flow of the first buffer concentrate can be adjusted based upon the total amount of the tempering component being added to the blend through the first and second buffer concentrates.

Methods and systems for interactive data input

Described herein are methods and systems to generate and display interactive graphical user interfaces that receive data inputs from users while emulating a chat session. A server retrieves a set of prompts associated with an electronic form; displays, within a webpage, a first element corresponding to a prompt and a second element having at least one input element configured to receive an input from a user interacting with the webpage. When the user interacts with an input element, the server relocates the first element and dynamically revises the second element by relocating the second element and displaying inputted values received from the user interacting with the at least one input element of the second element. The server then displays a third element comprising next prompts of the electronic form.

Oral administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] phosphonic acid and derivatives

Solid, pharmaceutical dosage forms of [2-(8,9-dioxo-2,6-diazabicyclo [5.2.0]non-1(7)-en-2-yl)alkyl]phosphonic acid and derivatives thereof are disclosed. In addition, methods of use are disclosed for the treatment, inter alia, of cerebral vascular disorders, anxiety disorders; mood disorders; schizophrenia; schizophreniform disorder; schizoaffective disorder; cognitive impairment; chronic neurodegenerative disorders; inflammatory diseases; fibromyalgia; complications from herpes zoster; prevention of tolerance to opiate analgesia; withdrawal symptoms from addictive drugs; and pain.

Antibodies against IL-18R1 and uses thereof

The invention provides anti-IL-18R1 antibodies and methods of using the same. 1. An isolated antibody that binds to human IL-18R1 comprising as heavy chain variable region CDRs a CDRH1 region of SEQ ID NO:2 or SEQ ID NO:10 , a CDRH2 region of SEQ ID NO:3 and a CDRH3 region of SEQ ID NO:4 , and as light chain variable region CDRs a CDRL1 region of SEQ ID NO:6 , a CDRL2 region of SEQ ID NO:7 and a CDRL3 region of SEQ ID NO:8 or a humanized version thereof.2. The antibody of wherein said antibody comprises:a. a variable heavy chain region comprising SEQ ID NO:1 and a variable light chain region comprising SEQ ID NO:5; orb. a heavy chain variable region comprising SEQ ID NO:9 and a variable light chain region comprising SEQ ID NO:11,c. a humanized version of (a) or (b).3. The antibody of wherein said antibody binds to human IL-18R1 with a binding affinity of 10M or less.4. The antibody of wherein the antibody is a human antibody.5. The antibody of wherein the antibody is either IgG1 or IgG4.6. An isolated antibody that binds to human IL-18R1 wherein said antibody binds to the same human IL-18R1 epitope to which a monoclonal antibody comprising a variable heavy chain region comprising SEQ ID NO:1 and a variable light chain region comprising SEQ ID NO:5 binds.7. The antibody of wherein said antibody binds to human IL-18R1 with a binding affinity of 10M or less.8. The antibody according to claim 6 , wherein the isolated antibody has variable heavy chain region and variable light chain region CDRs selected from:a) as heavy chain variable region CDRs a CDRH1 region of SEQ ID NO:30, a CDRH2 region of SEQ ID NO:31 and a CDRH3 region of SEQ ID NO:32, and as light chain variable region CDRs a CDRL1 region of SEQ ID NO: 34, a CDRL2 region of SEQ ID NO:35 and a CDRL3 region of SEQ ID NO:36;b) as heavy chain variable region CDRs a CDRH1 region of SEQ ID NO: 38, a CDRH2 region of SEQ ID NO:39 and a CDRH3 region of SEQ ID NO:40, and as light chain variable region CDRs a CDRL1 region ...

HER-2 Binding Antibodies

The present invention relates to monoclonal antibodies that specifically bind to HER2, or a fragment or derivative thereof or a polypeptide that contains at least a portion of said antibody that is sufficient to confer specific HER2 binding to the polypeptide. Said antibodies bind to the human Fc receptor and induce FcR mediated signaling pathways. The antibodies according to the invention bind to a different epitope than trastuzumab. The invention also relates to the use of an antibody according to the invention in the treatment of a HER-2 mediated disease. The present invention also relates to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of the antibody according to the invention, and the use of said composition in the treatment of a HER-2 mediated disease. 1. Monoclonal antibody that specifically binds to HER2 , or a fragment or derivative thereof or a polypeptide that contains at least a portion of said antibody that is sufficient to confer HER2 binding specificity , comprising:a) a heavy chain variable (VH) region is at least 90% identical to a VH region selected from the group consisting of VH regions of SEQ ID NO: 1 to 6 and SEQ ID NO: 100 to 101, andb) a light chain variable (VL) region that is at least 90% identical to a VL region selected from the group consisting of VL regions of SEQ ID NO: 7 to 12 and SEQ ID NO 102 to 104.2. Antibody according to claim 1 , wherein the antibody comprises a heavy chain variable (VH) region that is at least 90% identical to the VH region of SEQ ID NO: 4.3. Antibody according to claim 1 , wherein the antibody comprises a light chain variable (VL) region that is at least 90% identical to the VL region of SEQ ID NO: 10.4. Antibody according to claim 1 , wherein the antibody comprises a VH region selected from the group of VH regions comprising a CDR-H1 region of SEQ ID NO: 13+n claim 1 , a CDR-H2 region of SEQ ID NO: 19+n and a CDR-H3 region of SEQ ID NO: ...

Identification of human cell lines for the production of human proteins by endogenous gene activation

A process for selecting human cells for the production of human proteins by endogenous gene activation allows human proteins to be produced in economically feasible quantities and in a form suitable for producing a pharmaceutical composition. Also disclosed is a process for producing human proteins in a cell line identified in this matter.

Antibodies against CCR5 and uses thereof

An antibody binding to CCR5 characterized in that the heavy chain variable domain comprises an amino acid sequence of SEQ ID NO: 1, and has advantageous properties for the treatment of immunosuppressive diseases.

Monoclonal antibodies of isotype IgG which bind specifically to glutamate decarboxylase, and uses thereof

The invention concerns human monoclonal antibodies of the IgG isotype against human pancreatic islet cells which can be obtained by immortalizing human lymphocytes of prediabetics or diabetics, treating the culture supernatant of the immortalized cells with a conjugate of antibodies against human Fc gamma and a label, subsequently treating with human immunoglobulin, incubating with immobilized human pancreatic islet cells identifying an immortalized human cell culture which produces an antibody against pancreatic islet cells via determination of the label bound to the immobilized islet cells, isolating a human immortalized cell which produces this antibody, propagating this immortalized cell and isolating the monoclonal antibody produced by these cells. The invention also concerns a process for the isolation of an islet cell antigen to which such antibodies bind as well as a method for the determination of antibodies against an islet cell antigen of the pancreas.

Substrate treatment process

In a substrate treatment process, substrates are moved by a transporting device in a transporting direction through a substrate treatment installation having a number of chambers. The substrates are moved by transporting sections of the transporting device driven independently of one another. The transporting sections are driven such that, if substrates dwell temporarily in the transporting section, they are moved back and forth. Stresses in a substrate brought about by differing inputs of heat as a result of both process-induced and malfunction-induced dwell times of the substrate in a chamber are reduced by compensating within the chamber for a structurally brought about input of heat into the substrate, varying periodically over the length of the chamber, during temporary dwelling of the substrate in the chamber by moving the substrate back and forth over at least one period of the heat input by a change of the transporting direction.

PROCESSING APPARATUS FOR PACKAGING MACHINES

The invention relates to a processing apparatus for packaging machines having at least one upper processing unit for processing upper package sides and at least one lower processing unit for processing lower package sides, and having a common adjustment axle for the processing units along which the processing units are adjustable manually or by means of a drive in an adjustment direction that extends in parallel with a direction of transport of the packaging machine. 1. A processing apparatus for packaging machines , the processing apparatus comprising:at least one upper processing unit for processing upper package sides and at least one lower processing unit for processing lower package sides; anda common adjustment axle for the processing units along which the processing units are adjustable manually or by means of a drive in an adjustment direction that extends in parallel with a direction of transport of the packaging machine.2. The processing apparatus in accordance with claim 1 ,wherein the processing apparatus is for labeling and/or printing packages.3. The processing apparatus in accordance with claim 1 ,wherein a common travel drive for the two processing units is provided by which the processing units are travelable along the adjustment axle.4. The processing apparatus in accordance with claim 1 ,wherein the drive comprises an elongated drive member extending in the adjustment direction for the processing units.5. The processing apparatus in accordance with claim 4 ,wherein the elongated drive member comprises one of a spindle, a toothed belt, and a gear rack.6. The processing apparatus in accordance with claim 1 ,wherein the processing units can be coupled to the adjustment axle and can be decoupled from the adjustment axle independently of one another.7. The processing apparatus in accordance with claim 1 ,wherein every processing unit comprises a coupling device that is manually actuable or is controllable by means of a control device and that is ...

HIGH STRENGTH, HIGH STRESS CORROSION CRACKING RESISTANT AND CASTABLE Al-Zn-Mg-Cu-Zr ALLOY FOR SHAPE CAST PRODUCTS

The present invention provides an Al—Zn—Mg—Cu casting alloy that provides high strength for automotive and aerospace applications and optimized stress corrosion cracking resistance in highly corrosive and tensile environments. The inventive alloy composition includes about 3.5 wt. % to about 5.5 wt. % Zn; about 1.0 wt. % to about 3.0 wt. % Mg; about 0.5 wt. % to about 1.2 wt. % Cu; less than about 1.0 wt. % Si; less than about 0.30 wt. % Mn; less than about 0.30 wt. % Fe; and a balance of Al and incidental impurities.

Methods for identifying human cell lines useful for endogenous gene activation, isolated human cell lines identified thereby, and uses thereof

The invention concerns human cells which, due to an activation of the endogenous human EPO gene, are able to produce EPO in an adequate quantity and purity to enable a cost-effective production of human EPO as a pharmaceutical preparation. Furthermore the invention concerns a process for the production of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO gene in human cells as well as a process for the large-scale production of EPO in human cells.

Antibodies against CCR5 and uses thereof

Antibodies that specifically bind to CCR5 are useful for treating immunosuppressive disease.

2-(2,6-Dichlorophenyl)-Diarylimidazoles

This invention is directed to compounds of formula (I), which are valuable therapeutics for the treatment of cancer and cancer related diseases.

Antibodies against IL-18R1 and uses thereof

The invention provides anti-IL-18R1 antibodies and methods of using the same.

Identification of human cell lines for the production of human proteins by endogenous gene activation

A process for selecting human cells for the production of human proteins by endogenous gene activation allows human proteins to be produced in economically feasible quantities and in a form suitable for producing a pharmaceutical composition. Also disclosed is a process for producing human proteins in a cell line identified in this matter.

Two-stage playback: verifying user intent to watch an embedded video

A method for facilitating monetization of an embedded video configured for automated playback includes detecting, via an iframe embedded in a user interface of a third party platform, an indication of a user intent to view the video configured for automated playback. The video is hosted by a content sharing platform and embedded in the user interface of the third party platform. The method further includes providing, to a client device, video related data pertaining to the automated playback of the video in the user interface of the third party platform, and upon receiving the video-related data, validating the automated playback of the video in the user interface of the third party platform.

[[2-(Amino-3,4-dioxo-1-cyclobuten-1-yl)amino]alkyl]-acid derivatives for the treatment of pain

This invention provides a method of treating pain in a mammal that includes administering to a mammal in need of such treatment a pain treating effective amount of a compound of the formula (I): where R1 is H, alkyl or phenylalkyl; R2 is H, alkyl, alkenyl or phenylalkyl; or R1 and R2 taken together as Z are —CH2C—H2—, —CH2C(R6)(R7)CH2— or —CH2C(R8)(R9)—C(R10)(R11)CH2—, where R6, R8 and R10 are, independently, H, alkyl or hydroxyl and R7, R9 and R11 are, independently, H or alkyl; A is alkylene or alkenylene; X is CO2R3, P(O)(OR4)(OR5), 3,5-dioxo-1,2,4-oxadiazolidin-2-yl or 5-tetrazolyl in which R3, R4 and R5 are, independently, H or alkyl, or a pharmaceutically acceptable salt thereof. The present invention also provides pharmaceutical compositions for treating pain containing a pain treating effective amount of the compound of formula (I).

Conjugate of an antibody against CCR5 and an antifusogenic peptide

The current invention is related to a conjugate comprising one or more antifusogenic peptides and an anti-CCR5 antibody (mAb CCR5) characterized in that one to eight antifusogenic peptides are each conjugated to one terminus of the heavy and/or light chains of the anti-CCR5 antibody and to the pharmaceutical use of the conjugate.

PROCESSING ARRANGEMENT AND METHOD FOR CONDITIONING A PROCESSING ARRANGEMENT

A processing arrangement comprising: a process chamber comprising an upper chamber wall, a lower chamber wall and two lateral chamber walls; an insulating structure, arranged between the processing region and each of the upper chamber wall, the lower chamber wall and the two lateral chamber walls, respectively, for thermally insulating the processing region, wherein the insulating structure is configured as gas-permeable at least in sections in such a way that a process gas from the processing region can flow out of the processing region in the direction in each of the upper chamber wall, the lower chamber wall and the two lateral chamber walls, respectively, through the insulating structure; and a gas channel, arranged between the insulating structure and each of the upper chamber wall, the lower chamber wall and the two lateral chamber walls, respectively, for pumping away the process gas which flows through the insulating structure.

Bottle

Collector design for computed radiography

A light collector and detector for collecting and detecting light emitted, reflected or transmitted by a scanned information medium, comprising: a planar mirror assembly for extending the width of a scanned information medium and for disposition substantially perpendicular thereto, the planar mirror assembly having a lower edge adjacent to the scanned medium and an upper edge spaced from the lower edge; first and second pyramidal mirrors located side by side facing the planar mirror, the pyramidal mirrors having respective upper edges spaced from the upper edge of the planar mirror and respective lower edges spaced from the lower edge of the planar mirror, thereby to form aligned slots for the passage of a scanning beam of light to a medium to be scanned and for allowing light emitted by, reflected from, or transmitted by the scanned medium to enter the collector; wherein the first pyramidal mirror has a first aperture in an apex region thereof and wherein the second pyramidal mirror has ...

Knock in transgenic mammal containing a non-functional N-terminus of Kv beta 1.1 subunit

This invention provides a transgenic mammal containing a defective beta 1 subunit (Kvβ1) of a voltage sensitive potassium channel, where the Kvβ1 subunit is unable to confer N-type inactivation of the K+ but retains the ability to co-associate with Kv1 family α-subunits and thereby enhance channel surface expression. Preferably the Kvβ1.1 gene encoding Kvβ1 subunit has a mutation in all or a portion of codons 1-70 of its inactivation domain. The transgenic mammal is useful as a model for psychiatric and neurological disorders to identify anxiolytic compounds and pro-cognitive functions. The invention also provides for methods for screening and evaluating test compounds for their ability to modulate Kvβ1.1 activity, specifically for inactivation of a potassium channel or for co-association with α-subunits.

Heat treatable Al-Zn-Mg-Cu alloy for aerospace and automotive castings

A heat treatable aluminum alloy for shaped castings includes from about 3.5-5.5% Zn, from about 1-3% Mg, about 0.05-0.5% Cu, and less than about 1% Si.

Handling snack food chips

An apparatus for handling three-dimensionally curved snack food chips. The apparatus includes a first conveyor for conveying a series of the snack food chips on a conveying surface and an inverting station located at an output end of the first conveyor. The inverting station includes an inverter configured for transferring the snack food chips from an output end of the first conveyor into contact with an internal concave surface of the inverter. A drive system for the inverter is configured to move the internal concave surface downwardly to cause movement of the snack food chips downward from an upper portion to a lower portion of the internal concave surface. A depositing station is located and configured for depositing the snack food chips from the lower portion of the internal concave surface onto a second conveyor configured for receiving snack food chips from the depositing station and conveying them away.

Identification of human cell lines for the production of human proteins by endogenous gene activation

A process for selecting human cells for the production of human proteins by endogenous gene activation allows human proteins to be produced in economically feasible quantities and in a form suitable for producing a pharmaceutical composition. Also disclosed is a process for producing human proteins in a cell line identified in this matter.

2-(2,6-Dichlorophenyl)-Diarylimidazoles

This invention is directed to compounds of formula (I), which are valuable therapeutics for the treatment of cancer and cancer related diseases.

2-(2,6-dichlorophenyl)-diarylimidazoles

The invention is directed to compounds of formula (I), which are valuable therapeutics for the treatment of cancer and related diseases.

COMBINATION SAMPLING AND PRESSURE RELIEF VALVE

The present invention discloses a combination sampling and pressure relief valve. In particular embodiments, the valve includes a main body having a central bore therethrough, the central bore having first and second chamfered surfaces; a front surface having an aperture in communication with the central bore; and a rear surface having an aperture in communication with the central bore; a valve seat/stem assembly located within the central bore, the valve seat/stem assembly having first and second chamfered surfaces that are complementary to the main bore chamfered surfaces; a spring extending between the valve seat/stem assembly and a rear end cap of the valve; and, a drain aperture extending perpendicularly from the central bore to ambient, the drain aperture located between the central bore first and second chamfered surfaces. Other embodiments of the valve are disclosed.

Preparation of erythropoietin by endogenous gene activation

The invention relates to human cells which are capable, on the basis of an activation of the endogenous human EPO gene, of producing EPO in a sufficient amount and purity to make possible a cost-effective production of human EPO as a pharmaceutical preparation. The invention furthermore relates to a method for the preparation of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO in human cells, and a method for the large technical production of EPO in human cells.

Package for data medium

Aluminum alloy for producing high performance shaped castings

An aluminum alloy for shaped castings, the alloy having the following composition ranges in weight percent: about 6.0-8.5% silicon, less than 0.4% magnesium, less than 0.1% cerium, less than 0.2% iron, copper in a range from about 0.1% to about 0.5% and/or zinc in a range from about 1% to about 4%, the alloy being particularly suited for T5 heat treatment.

Control system for mining machine

A mining machine such as a mining shovel includes a digging assembly having an upward extending boom and a dipper assembly generally horizontally supported by the boom and configured to crowd toward and retract from a vertical bank at a mine site. To determine if the dipper assembly strikes the bank, an electronic controller can calculate a calculated crowd force based in part on a crowd motor torque associated with a crowd motor, a crowd speed of the dipper assembly, and an inertia parameter. If the calculated crowd force exceeds a predetermined first crowd threshold, the electronic controller can register an impact event. In further aspects, the electronic controller can execute a force modification function to modify the crowding forces and a speed reduction function to reduce the crowd speed.

Heat treatable Al-Zn-Mg alloy for aerospace and automotive castings

A heat treatable aluminum alloy for shaped castings includes from about 3.5-5.5% Zn, from about 1-1.5% Mg, less than about 1% Si, less than about 0.30% Mn, and less than about 0.3% Fe and other incidental impurities.

PACKAGING MACHINE FOR PRODUCING PACKAGING COMPRISING A TRANSPONDER

The invention relates to a packaging machine for packing food products in a plastic packaging, said machine comprising a device for applying a transponder to the plastic packaging, and a system for data exchange between the transponder and a computer unit and/or a regulating unit, by which means data can be transmitted to the transponder or called therefrom.

Control System for Mining Machine

A mining machine such as a mining shovel includes a digging assembly having an upward extending boom and a dipper assembly generally horizontally supported by the boom and configured to crowd toward and retract from a vertical bank at a mine site. To determine if the dipper assembly strikes the bank, an electronic controller can calculate a calculated crowd force based in part on a crowd motor torque associated with a crowd motor, a crowd speed of the dipper assembly, and an inertia parameter. If the calculated crowd force exceeds a predetermined first crowd threshold, the electronic controller can register an impact event. In further aspects, the electronic controller can execute a force modification function to modify the crowding forces and a speed reduction function to reduce the crowd speed.

Control system for a rotating machine

A system for setting a dump height of a material engaging work implement above a dump body includes a rotatable implement system, an implement system pose sensor, and a bed height sensor. A controller determines an initial bed height, determines an initial dump height, generates a command based upon the pose of the work implement, and determines a subsequent dump height higher than the initial dump height. The controller is further configured to position the work implement at the subsequent dump height, determine a further subsequent dump height higher than the subsequent dump height, and position the work implement at the further subsequent dump height over the dump body.

Preparation of erythropoietin by endogenous gene activation

The invention relates to human cells which are capable, on the basis of an activation of the endogenous human EPO gene, of producing EPO in a sufficient amount and purity to make possible a cost-effective production of human EPO as a pharmaceutical preparation. The invention furthermore relates to a method for the preparation of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO in human cells, and a method for the large technical production of EPO in human cells.

COLUMN PRESSURE REGULATION SYSTEM AND METHOD

A system for regulating a pressure of a piston on a bed in a flow through column system, where the flow through column system includes a piston pressure chamber in communication with the piston and an inlet line and an outlet line in communication with the bed. A pump has an inlet in communication with a supply of hydraulic fluid. A forward pressure reference communicates with the inlet line. A forward pressure regulator has a reference inlet in communication with the forward pressure reference and an inlet in communication with the pump. A switching valve communicates with the piston pressure chamber, and also has a inlet in communication with the outlet of the forward pressure regulator. A back pressure reference communicates with the outlet line. A back pressure regulator has an inlet in communication with the outlet of the switching valve, a reference inlet in communication with the back pressure reference and an outlet in communication with the supply of hydraulic fluid. The switching valve may be manipulated so that a pressure in the piston pressure chamber is controlled by either the forward pressure regulator or the back pressure regulator. 1. A system for regulating a pressure of a piston on a bed in a flow through column system , where the flow through column system includes a piston pressure chamber in communication with the piston and an inlet line and an outlet line in communication with the bed , comprising:a. a supply of hydraulic fluid;b. a pump having an inlet in communication with the supply of hydraulic fluid and an outlet;c. a forward pressure reference adapted to communication with the column system inlet line:,d. a forward pressure regulator having a reference inlet in communication with the forward pressure reference, an inlet in communication with the outlet of the pump and an outlet;e. a switching valve adapted to communicate with the column system piston pressure chamber, said switching valve also having an inlet in communication with the ...

SYSTEMS AND METHODS FOR STABILIZING POWER RATE OF CHANGE WITHIN GENERATOR BASED APPLICATIONS

Systems and methods for monitoring an electrical energy storage unit and a parameter related to the load and based on the monitoring, if the load parameter is greater than a second rate of change of electrical power for a second component of an electrical power system, providing power from the electrical energy storage unit to the second component until the load parameter and the second component have equivalent rates of change of electrical power. 1. A method for stabilizing power rate of change in an electrical power system using an electrical energy storage unit , the method comprising:receiving electrical power from an initial source;providing electrical power within the electrical power system;receiving a notification that a first rate of change of electrical power is being provided to a first component of the electrical power system and a second rate of change of electrical power is being provided to a second component of the electrical power system;charging the electrical energy storage unit with a load from the first and second component of the electrical power system;monitoring the electrical energy storage unit and a parameter related to the load; andbased on the monitoring, if the load parameter is greater than the second rate of change of electrical power for the second component of the electrical power system, providing power from the electrical energy storage unit to the second component until the load parameter and the second component have equivalent rates of change of electrical power.2. The method of claim 1 , wherein the first component of the electrical power system comprises a device configured to operate using a generator.3. The method of claim 2 , wherein the device comprises at least one of an electric rope shovel claim 2 , a long wall miner claim 2 , and an electric power drill.4. The method of claim 2 , wherein the device comprises a mining excavator.5. The method of claim 3 , wherein the mining excavator comprises at least one of an ...

SHARING CONTENT IN A MESSAGING APPLICATION

A device implementing a system for sharing groups of files within a messaging application includes a processor configured to provide, within the messaging application, a user interface element for sending at least one file to a participant in an active message thread of the messaging application, the at least one file having been determined to be relevant to the participant. The processor is further configured to, responsive to receiving a selection of the user interface element: transmit, to a server, a request to store the at least one file in association with a shared storage area, and to transmit, via the messaging application, a message to the participant in the active message thread, the message comprising information for accessing the at least one file associated with the shared storage area. 1. A method , comprising:receiving, by a device of a user, a message comprising a network identifier for accessing at least one file associated with a shared storage area, the network identifier comprising a parameter for accessing contextual information of the least one file from the shared storage area, the at least one file having been determined to be relevant to the user;displaying, by the device, a message element within an active message thread of a messaging application, the message element providing an interface for the user to accept access to the at least one file;receiving, via the interface, user input indicating that the user has accepted access to the at least one file;obtaining, in response to receiving the user input and based on the network identifier, the at least one file associated with the shared storage area; andproviding, based in part on account information of the user, the at least one file for display on the device.2. The method of claim 1 , wherein the shared storage area corresponds to a cloud-based service having multiple user accounts associated therewith.3. The method of claim 2 , wherein in a case where the user has a user account on the ...

PASSIVE OCCUPANT RESTRAINT FOR SIDE-FACING AIRCRAFT SEATS

In one aspect, a side-facing seat assembly is provided. The seat assembly includes a seat portion, a back portion having an upper surface extending along the width of the back portion, and an arm restraint assembly coupled to the back portion. The arm restraint assembly includes a rotating bar rotatable between a stowed position oriented with the back portion upper surface and a deployed position. In the deployed position the rotating bar extends from the back portion and facilitates restraining an occupant seated in the seat assembly. The seat assembly further includes a leg restraint assembly coupled to the seat portion. The leg restraint assembly includes an extension bar extendable between a stowed position oriented with the seat portion and a deployed position. In the deployed position the extension bar extends from the seat portion and facilitates restraining an occupant seated in the seat assembly. 1. A seat assembly comprising:a seat portion;a back portion having an upper surface; andan arm restraint assembly coupled to the back portion, the arm restraint assembly including a rotating bar rotatable between a stowed position oriented along the upper surface and a deployed position, wherein in the deployed position the rotating bar extends from the back portion and facilitates restraining an occupant seated in the seat assembly.2. A seat assembly comprising:a seat portion;a back portion; anda leg restraint assembly coupled to the seat portion, the leg restraint assembly including an extension bar extendable between a stowed position oriented with the seat portion and a deployed position, wherein in the deployed position the extension bar extends from the seat portion and facilitates restraining an occupant seated in the seat assembly.3. The seat assembly of claim 2 , wherein the leg restraint assembly further comprises a biasing mechanism to bias the extension bar into the deployed position when the biasing mechanism is engaged.4. A side-facing seat assembly ...

Remote-Control Slope Mowing System with Safety Features

Mowing systems include a mower and a remote control unit such as a handheld unit, between which is provided 1- or 2-way communications. Components and features are included in the mower, the remote control unit, or both to enhance the safety, functionality, or user experience of the system's user/operator. One aspect relates to an enable switch on the remote control unit that requires activation within a specified time before activating a drive system or PTO unit. Another aspect relates to sharing diagnostic information between the mower and remote control unit and emitting user-detectable warnings in response to the shared information. Another aspect relates to reducing a danger level of the system, e.g. disabling the PTO unit or slowing a drive speed transform function, when a proximity between the mower and the remote control unit is too small. Another aspect relates to controlling operation of the mower based on tilt angles of both the mower and the remote control unit. 1. A remote-control mowing system , comprising: an engine selectively coupled to mower blades via a power takeoff (PTO) unit,', 'a drive system for transporting the mower along terrain,', 'a first antenna, and', 'a first controller coupled to the PTO unit, the drive system, and the first antenna; and, 'a mower having one or more user input device(s) with which a user can issue at least a first command to start the engine, a second command to activate the drive system to move the mower in a desired direction, and a third command to activate the PTO unit,', 'an enable switch,', 'a second antenna, and', 'a second controller coupled to the user input device(s), the enable switch, and the second antenna such that the second controller wirelessly communicates with the first controller;, 'a remote handheld unit havingwherein the first and second controllers cooperate to start the mower's engine in response to the first command issued by the user input device(s); and (a) activate the drive system in ...

Handheld Unit with Safety Features for Remote-Control Slope Mowing System

Mowing systems include a remote control unit such as a handheld unit for use with a mower, between which is provided 1- or 2-way communications. Components and features are included in the mower, the remote control unit, or both to enhance the safety, functionality, or user experience of the system's user/operator. One aspect relates to a handheld unit having a logic-implemented safety interlock for a PTO switch and/or a speed switch to prevent such switches from becoming active simultaneously with an enablement command for the PTO unit and/or drive unit of the mower. Another aspect relates to incorporating an inclinometer and/or motion sensor such as an accelerometer into the handheld unit, and controlling operation of the mower based on outputs) from such sensor(s). Another aspect relates to providing a display or other visual indicator on the handheld unit, and displaying on the visual indicator an indication of a tilt angle of the mower. 1. In a remote-control mowing system that includes a mower having a power takeoff (PTO) unit , a drive system , and a first controller coupled to the PTO unit and the drive system , a handheld unit configured to wirelessly couple to the mower , the handheld unit comprising:an antenna;a second controller coupled to the antenna to wirelessly communicate with the first controller; and an enable switch configured to enable remote activation of the PTO unit, and', 'a PTO switch having an ON state and an OFF state, and configured to remotely turn the PTO unit ON and OFF, and, 'one or more user input device(s) coupled to the second controller, the user input device(s) including'}wherein the system is configured to operate as if the PTO switch were in the OFF state if the PTO switch is in the ON state when the enable switch is activated.2. The handheld unit of claim 1 , wherein the PTO switch comprises a mechanical switch.3. The handheld unit of claim 2 , wherein PTO switch comprises a toggle switch claim 2 , a rocker switch claim 2 , ...

Slope Mower with Safety Features

Mowing systems include a mower and, optionally, a remote control unit such as a handheld unit, between which may be provided 1- or 2-way communications. Components and features are included in the mower, the remote control unit, or both to enhance the safety, functionality, or user experience of the system's user/operator. One aspect relates to monitoring a tilt angle of the mower, and defining or executing different system responses as a function of different first and second conditions that relate to the tilt angle. Another aspect relates to automatic adjustment of a speed setting of the mower's drive system as a function of a power takeoff (PTO) unit of the mower. 1. A mower , comprising:a frame;an engine attached to the frame;mower blades attached to the frame and selectively coupled to the engine by a power takeoff (PTO) unit;a controller configured to separately control the PTO unit and the engine; andan inclinometer attached to the frame and coupled to the controller, the inclinometer providing an inclinometer output indicative of a tilt angle of the frame;wherein the controller is configured to turn the PTO unit off but keep the engine on when the inclinometer output satisfies a first condition, and configured to turn the engine off when the inclinometer output satisfies a second condition.2. The mower of claim 1 , wherein the first condition comprises the tilt angle exceeding a first value claim 1 , and the second condition comprises the tilt angle exceeding a second value greater than the first value.3. The mower of claim 2 , wherein the first condition comprises the tilt angle exceeding the first value for a first nonzero time interval claim 2 , and the second condition comprises the tilt angle exceeding the second value for a second time interval claim 2 , the second time interval being less than the first time interval.4. The mower of claim 1 , wherein the first condition comprises the tilt angle exceeding a first value claim 1 , and the second ...

Switchgear Enclosure Housing Assembly Including An Extendable Conductor Assembly

An enclosure housing assembly for an electrical switching apparatus is provided. The enclosure housing assembly includes a sidewall assembly, a movable carriage assembly, a ground bus bar assembly and a movable terminal assembly with an extendable conductor assembly. The sidewall assembly includes a number of sidewalk defining an enclosed space. The movable carriage assembly is movable between a withdrawn, first position. wherein the movable carriage assembly is disposed partially outside the enclosure sidewall assembly enclosed space, and an inserted, second position, wherein the movable carriage assembly is disposed substantially inside the enclosure sidewall assembly enclosed space. The ground bus bar assembly is coupled to the first sidewall. The movable terminal assembly is coupled to the movable carriage assembly whereby the movable terminal assembly moves with the movable carriage assembly. The extendable conductor assembly is coupled to, and in electrical communication with, the ground bus bar assembly.

SUBSTRATE TREATMENT PROCESS

In a substrate treatment process, substrates are moved by a transporting device in a transporting direction through a substrate treatment installation having a number of chambers. The substrates are moved by transporting sections of the transporting device driven independently of one another. The transporting sections are driven such that, if substrates dwell temporarily in the transporting section, they are moved back and forth. Stresses in a substrate brought about by differing inputs of heat as a result of both process-induced and malfunction-induced dwell times of the substrate in a chamber are reduced by compensating within the chamber for a structurally brought about input of heat into the substrate, varying periodically over the length of the chamber, during temporary dwelling of the substrate in the chamber by moving the substrate back and forth over at least one period of the heat input by a change of the transporting direction. 1. A substrate treatment process , in which substrates are moved by a transporting device in a transporting direction through a substrate treatment installation having a number of chambers , the substrates being moved by transporting sections of the transporting device that are driven independently of one another and the transporting sections of the transporting device being driven in such a way that , if the substrates dwell temporarily in a first transporting section , substrates arranged on the first transporting section are moved back and forth in an oscillating movement , wherein , within a chamber of the substrate treatment installation , compensation is provided for a structurally brought about input of heat into a substrate , varying periodically over a length of the chamber , during temporary dwelling of the substrate in the chamber , by the substrate located in the chamber being moved back and forth over at least one period of the heat input by a periodic change of transporting direction.2. The substrate treatment process ...

RESTRAINT FOR SIDE FACING SEATS INSTALLED IN AN AIRCRAFT

A personal restraint system configured for use with a seat oriented perpendicular to a direction of flight of an aircraft is provided including a lap portion and a shoulder portion. The lap portion includes a first belt having a belt buckle and a second belt having a belt connector. The first belt is arranged a first side of the seat and the second belt is arranged adjacent a second side of the seat. The belt connector removably couples to the belt buckle. A shoulder portion includes a retractable third belt having a coupling configured to selectively couple to one of the belt buckle and the belt connector. A pretensioner operably coupled to either the first belt or the second belt includes at least one sensor configured to monitor one or more aircraft conditions. Upon detection of a predetermined aircraft condition, the pretensioner applies tension to the first or second belt. 1. A personal restraint system configured for use with a seat oriented perpendicular to a direction of flight of an aircraft , comprising: a first belt having a belt buckle attached thereto, the first belt being arranged adjacent a first side of the seat; and', 'a second belt having a belt connector attached thereto, the second belt being arranged adjacent a second side of the seat, and the belt connector being configured to removably couple to the belt buckle;, 'a lap portion includinga shoulder portion including a retractable third belt, the third belt including a coupling configured to selectively couple to one of the belt buckle and the belt connector; anda pretensioner operably coupled to one of the first belt and the second belt, the pretensioner including at least one sensor configured to monitor one or more aircraft conditions, wherein upon detection of a predetermined aircraft condition, the pretensioner is configured to apply tension to the first belt or second belt.2. The personal restraint system according to claim 1 , wherein the aircraft conditions are defined by an aircraft ...

SYSTEM AND METHOD FOR SWING CONTROL

A swing control assembly for a first machine is provided. The swing control assembly includes a position detection module configured to generate a signal indicative of a relative position of a second machine with respect to the first machine. The swing control assembly includes a controller communicably coupled to the position detection module. The controller is configured to receive the signal indicative of the relative position of the second machine with respect to the first machine. The controller is configured to determine a direction of swing associated with the first machine based on the received signal. The controller is configured to provide an instruction to initiate a swing operation of the first machine based on the determined direction of swing. 1. A swing control assembly for a first machine , the swing control assembly comprising:a position detection module configured to generate a signal indicative of a relative position of a second machine with respect to the first machine; and receive the signal indicative of the relative position of the second machine with respect to the first machine;', 'determine a direction of swing associated with the first machine based on the received signal; and', 'provide an instruction to initiate a swing operation of the first machine based on the determined direction of swing., 'a controller communicably coupled to the position detection module, the controller configured to2. The swing control assembly of claim 1 , wherein the position detection module includes a position detection sensor provided on the second machine claim 1 , the position detection sensor configured to generate a signal indicative of a current position of the second machine.3. The swing control assembly of claim 2 , wherein the position detection sensor includes at least one of a global positioning system claim 2 , an accelerometer claim 2 , and a gyroscope.4. The swing control assembly of claim 1 , wherein the position detection module includes a ...

APPARATUSES, SYSTEMS, AND METHODS FOR SAMPLE CAPTURE AND EXTRACTION

Methods, apparatuses, and systems associated with aerosol collection devices (such as, but not limited to, breath-aerosol collector devices, breathalyzers) are provided. An example aerosol collection device includes a sample transfer adapter configured to receive a sample and a device body connected to the sample transfer adapter. In some examples, the device body defines a flow channel that guides the sample to a filter component, and the filter component contains a buffer solution.

Apparatuses, systems, and methods for sample capture and extraction

Methods, apparatuses, and systems associated with aerosol collection devices (such as, but not limited to, breath-aerosol collector devices, breathalyzers) are provided. An example aerosol collection device includes a sample transfer adapter configured to receive a sample and a device body connected to the sample transfer adapter. In some examples, the device body defines a flow channel that guides the sample to a filter component, and the filter component contains a buffer solution.

Apparatuses, systems, and methods for sample capture and extraction

Methods, apparatuses, and systems associated with aerosol collection devices (such as, but not limited to, breath-aerosol collector devices, breathalyzers) are provided. An example aerosol collection device includes a sample transfer adapter configured to receive a sample and a device body connected to the sample transfer adapter. In some examples, the device body defines a flow channel that guides the sample to a filter component, and the filter component contains a buffer solution.

APPARATUSES, SYSTEMS, AND METHODS FOR SAMPLE CAPTURE AND EXTRACTION

Methods, apparatuses, and systems associated with aerosol collection devices (such as, but not limited to, breath-aerosol collector devices, breathalyzers) are provided. An example aerosol collection device includes a sample transfer adapter configured to receive a sample and a device body connected to the sample transfer adapter. In some examples, the device body defines a flow channel that guides the sample to a filter component, and the filter component contains a buffer solution.

Remote-Control Slope Mowing System with Inclinometers and Safety Features

Mowing systems include a mower and a remote control unit such as a handheld unit, between which is provided 1- or 2-way communications. Components and features are included in the mower, the remote control unit, or both to enhance the safety, functionality, or user experience of the system's user/operator. Aspects of the invention relate to: an enable switch on the remote control unit that requires activation within a specified time before activating a drive system or PTO unit; sharing diagnostic information between the mower and remote control unit and emitting user-detectable warnings in response to the shared information; reducing a danger level of the system when a proximity between the mower and the remote control unit is too small; and using inclinometers in the mower and the remote control unit to control operation of the mower based on tilt angles of both the mower and the remote control unit. 1. A remote-control mowing system , comprising: mower blades, a power takeoff (PTO) unit, and an engine selectively coupled to the mower blades via the PTO unit,', 'a drive system for transporting the mower along terrain,', 'a first inclinometer,', 'a first antenna, and', 'a first controller coupled to the PTO unit, the drive system, the first inclinometer, and the first antenna; and, 'a mower having one or more user input device(s) with which a user can issue commands to remotely control the mower,', 'a second inclinometer,', 'a second antenna, and', 'a second controller coupled to the user input device(s), the second inclinometer, and the second antenna such that the second controller wirelessly communicates with the first controller;, 'a remote handheld unit havingwherein the first and second controllers cooperate to control operation of the mower based on both a condition of the first inclinometer and a condition of the second inclinometer.2. The system of claim 1 , wherein the first controller is configured to turn the PTO unit off without turning the engine off ...

ROLL ON THE FLOOR CIRCUIT BREAKERS AND RELATED KITS AND METHODS

Roll on floor (ROF) circuit breakers include a plurality of support wheels configured to contact a support surface as the ROF circuit breaker is moved between locations. The support wheels have a rocker configuration whereby weight of the ROF circuit breaker is transferred between different sets of the wheels during movement to thereby facilitate ease of movement. 1. A roll on floor (ROF) circuit breaker , comprising:a ROF circuit breaker; anda plurality of support wheels attached to the ROF circuit breaker, the support wheels configured to contact a support surface as the ROF circuit breaker is moved between locations, wherein the support wheels have a rocker configuration whereby weight of the ROF circuit breaker is transferred between different sets of the wheels during movement on a flat surface to thereby facilitate ease of movement.2. The ROF circuit breaker of claim 1 , wherein the plurality of support wheels include claim 1 , on each side claim 1 , a first end wheel and a second end wheel claim 1 , the first and second end wheels positioned adjacent respective opposing ends of the side of the ROF circuit breaker claim 1 , and a third wheel positioned between the first and second end wheels claim 1 , wherein the third wheel has an axis of rotation that is below that of the first and second end wheels or has a larger diameter than the first and second end wheels.3. The ROF circuit breaker of claim 1 , wherein the support wheels are non-swivel wheels.4. The ROF circuit breaker of claim 1 , wherein the plurality of support wheels are six support wheels claim 1 , three on each side of the ROF circuit breaker claim 1 , and wherein the support wheels are attached to the ROF breaker to have a non-swivel configuration.5. The ROF circuit breaker of claim 1 , wherein the support wheels reside under metal wheels or rollers and are about 3 inches in diameter.6. The ROF circuit breaker of claim 1 , wherein the plurality of support wheels are six support wheels claim 1 , ...

OCULAR APPLICATIONS OF MATRIX BOUND VESICLES (MBVS)

Methods are disclosed herein for increasing retinal ganglion cell survival in a subject in need thereof. These methods include selecting a subject in need of increased retinal ganglion cell survival and administering a therapeutically effective amount of isolated nanovesicles derived from an extracellular matrix (MBVs) to the subject. 1. A method of increasing retinal ganglion cell survival in a subject in need thereof , comprisingselecting a subject in need of increased retinal ganglion cell survival, andlocally administering to an eye of the subject a therapeutically effective amount of isolated nanovesicles derived from an extracellular matrix, wherein the nanovesicles maintain expression of F4/80 and CD-11b on macrophages in the subject, wherein the nanovesicles comprise lysyl oxidase, and wherein the nanovesicles a) do not express CD63 or CD81, orb) are CD63loCD81lo,thereby increasing retinal ganglion cell survival in the subject.2. The method of claim 1 , wherein the extracellular matrix is a mammalian extracellular matrix.3. The method of claim 2 , wherein the mammalian extracellular matrix is a human extracellular matrix.4. The method of claim 1 , wherein the extracellular matrix is from esophageal tissue claim 1 , urinary bladder claim 1 , small intestinal submucosa claim 1 , dermis claim 1 , umbilical cord claim 1 , pericardium claim 1 , cardiac tissue claim 1 , tumor tissue claim 1 , or skeletal muscle.5. The method of claim 1 , wherein the nanovesicles comprise miR-145 and/or miR-181.6. The method of claim 1 , wherein the nanovesicles are administered locally to the eye of the subject.7. The method of claim 6 , wherein the nanovesicles are administered intravitreally or subretinally.8. The method of claim 6 , wherein the nanovesicles are administered repeatedly to the eye of the subject.9. The method of claim 8 , wherein the nanovesicles are administered weekly claim 8 , bimonthly or monthly to the subject.10. The method of claim 1 , wherein the subject ...

BATTERY BALANCING SYSTEM

Embodiments of the present invention are directed to a cell protection system that may be employed in high voltage systems such as grid scale energy storage systems. In some embodiments, the advanced cell protection system includes a proactive balancing system for balancing one or more battery units of the energy storage systems. In some embodiments, the advanced cell protection system includes a switching protection system for safely connecting and disconnecting the one or more battery units of the energy storage systems to other systems. In some embodiments, the advanced cell protection system includes an isolated communication system for allowing the one or more battery units to safely communicate with each other and at least one controller of the energy storage system. 1. A system , the system comprising:a plurality of battery units connected in series; anda plurality of bypass circuits, each bypass circuit being in parallel to one of the plurality of battery units; 'activate a first bypass circuit of the plurality of bypass circuits, the first bypass circuit being in parallel to a first battery unit of the plurality of battery units, wherein the first bypass circuit is activated based on a state of charge of the first battery unit, wherein upon activation of the first bypass circuit, current flows through the first bypass circuit and does not flow to the first battery unit.', 'wherein the system is configured to2. The system of claim 1 , wherein the system is configured to deactivate the first bypass circuit based on the state of charge of the first battery unit claim 1 , wherein upon deactivation of the first bypass circuit claim 1 , the current flows through the first battery unit and does not flow through the first bypass circuit.3. The system of claim 1 , wherein the system is configured to activate the first bypass circuit by:determining the state of charge of the first battery unit;determining that the state of charge of the first battery unit is not ...

Isolated communication system

Embodiments of the present invention are directed to a cell protection system that may be employed in high voltage systems such as grid scale energy storage systems. In some embodiments, the advanced cell protection system includes a proactive balancing system for balancing one or more battery units of the energy storage systems. In some embodiments, the advanced cell protection system includes a switching protection system for safely connecting and disconnecting the one or more battery units of the energy storage systems to other systems. In some embodiments, the advanced cell protection system includes an isolated communication system for allowing the one or more battery units to safely communicate with each other and at least one controller of the energy storage system.

SWITCHING PROTECTION SYSTEM

Embodiments of the present invention are directed to a cell protection system that may be employed in high voltage systems such as grid scale energy storage systems. In some embodiments, the advanced cell protection system includes a proactive balancing system for balancing one or more battery units of the energy storage systems. In some embodiments, the advanced cell protection system includes a switching protection system for safely connecting and disconnecting the one or more battery units of the energy storage systems to other systems. In some embodiments, the advanced cell protection system includes an isolated communication system for allowing the one or more battery units to safely communicate with each other and at least one controller of the energy storage system. 1. A protection system for selectively connecting one or more battery units of a battery system to a power system and disconnecting the one or more battery units of the battery system from the power system , via a bus , the protection system comprising: a first electrical path configured to be connected between a positive terminal of the bus and a positive terminal of the one or more battery units, the first electrical path comprising a first switch;', 'a second electrical path configured to be connected between a negative terminal of the bus and a negative terminal of the one or more battery units, the second electrical path comprising a second switch; and', 'a third electrical path connected in parallel to the first electrical path between the positive terminal of the bus and the positive terminal of the one or more battery units, the third electrical path comprising a third switch and an inductor; and, 'a bridge circuit configured to be connected between the bus and the one or more battery units, wherein the bridge circuit comprises 'control a switching frequency of the third switch in order to control an impedance of the inductor while (i) connecting the one or more battery units to the bus ...

Battery sourced power conversion

Embodiments of the present invention are directed to a battery sourced power conversion system and a balanced architecture employed in the battery sourced power conversion system comprising a first plurality of battery units connected in series, a plurality of switches, each switch being connected to one of the plurality of battery units, and at least one controller connected to the first plurality of battery units, wherein the at least one controller is configured to control the plurality of switches to generate a square wave output from each battery unit of the first plurality of battery units, wherein the square wave output associated with each battery units of the first plurality of battery units in combination form a desired output waveform having a plurality of steps.

ADAPTIVE USER PRESENCE AWARENESS FOR SMART DEVICES

A system and method are disclosed for determining pre-contact engagement of one or more users with a device such as an interactive digital display. The device may include sensors which are used to understand the nature of human presence around the device, including the environment of the device and the behavior of people around the device. Once the environment of the device, instances of pre-contact engagement with the device may be determined, at which point the device may be switched from an inactive state to an active state. 1. A device for detecting presence scenarios near the device , comprising:one or more sensors for providing feedback relating to an environment and user behavior near the device; anda processor configured to determine active engagement with the device by one or more users, prior to physical engagement with the device by the one or more users, the processor further configured to compare instances of determined active engagement with instances of physical engagement with the device to refine future instances of determined active engagement to more closely match future instances of physical engagement.2. The device of claim 1 , wherein the device comprises an interactive digital display.3. The device of claim 2 , wherein the interactive digital display switches from an inactive state to an active state upon a determination of active engagement by the processor.4. The device of claim 2 , wherein the one or more sensors comprise at least one of an infrared sensor claim 2 , an ambient light sensor claim 2 , a camera and a microphone.5. The device of claim 1 , wherein the processor determines active engagement using a baseline routine that determines a baseline for an amount of human presence in a vicinity of the device as detected by the one or more sensors claim 1 , active engagement being determined when the amount of human presence in the vicinity of the device exceeds the baseline by a differential amount.6. The device of claim 5 , wherein the ...

FULLY INTEGRATED MANUAL OPENING MECHANISM ON MEDIUM VOLTAGE CIRCUIT BREAKER

A manual opening assembly includes a manual actuator assembly. The manual actuator assembly includes a handle assembly and a number of operating levers. The handle assembly includes a handle member structured to be movably coupled to a circuit breaker housing assembly and to move between an operating position and an opening position. The handle member is operatively coupled to the number of operating levers. The number of operating levers are movably coupled to a circuit breaker housing assembly. The operating levers are structured to move between an operating position, wherein the operating levers do not operatively engage a linkage assembly, and an opening position, wherein the operating levers operatively engage the linkage assembly and move the linkage assembly from a closed, second configuration to an open, first configuration. 1. A manual opening assembly for a circuit breaker operating mechanism , said circuit breaker including a housing assembly , a number of pairs of separable contacts , and said operating mechanism , each pair of separable contacts structured to move between an open , first configuration , wherein the contacts in each pair of separable contacts are spaced from each other , and a second configuration , wherein the contacts in each pair of separable contacts are coupled to , and in electrical communication with , each other , said operating mechanism including a linkage assembly , a bias assembly , and an electromagnetic actuator , said linkage assembly structured to move between a first configuration and a second configuration , said linkage assembly operatively coupled to each pair of separable contacts , wherein , when said linkage assembly is in said first configuration , each pair of separable contacts are in the first configuration , and wherein , when said linkage assembly is in said second configuration , each pair of separable contacts are in the second configuration , said electromagnetic actuator is operatively coupled to said ...

SCALEABLE INLINE BUFFER DILUTION SCHEME

An inline buffer dilution system is provided that includes a first flow control valve fluidly connected to a supply of diluent liquid, second and third flow control valves fluidly connected to supplies of a first buffer and a second buffer, respectively, and a mixing pump fluidly connected to the first, second, and third flow control valves and configured to mix an amount of the diluent liquid, the first buffer, and the second buffer to produce a diluted buffer solution. The system further includes a backpressure control valve configured to generate a backpressure that promotes mixing within the mixing pump, and a controller configured to control the backpressure based on the amount of the diluent liquid, the first buffer, and the second buffer being mixed in the mixing pump, such that the mixing pump yields a minimum mixing threshold across a range of fluid flows. 1. An inline buffer dilution system , comprising:a first flow control valve adapted to communicate with a vessel comprising a supply of diluent liquid;a second flow control valve adapted to communicate with a first vessel comprising a supply of a first buffer;a third flow control valve adapted to communicate with a second vessel comprising a supply of a second buffer;a mixing pump fluidly connected to the first, second, and third flow control valves and configured to receive an amount of the diluent liquid, the first buffer, and the second buffer via the first, second, and third flow control valves, respectively, the mixing pump further configured to mix the amount of the diluent liquid, the first buffer, and the second buffer to produce a diluted buffer solution;a backpressure control valve arranged downstream of the mixing pump and configured to generate a backpressure that promotes mixing within the mixing pump; anda controller communicatively connected to the mixing pump and the backpressure control valve, the controller configured to control the backpressure generated by the backpressure control ...

EXCAVATION SYSTEM HAVING INTER-MACHINE MONITORING AND CONTROL

An excavation system is disclosed for use with an excavation machine having a work tool and with an IPCC. The excavation system may have a location device configured to generate a first signal indicative of a location of the excavation machine, a display, and at least one controller in communication with the location device and the display. The controller may be configured to receive a second signal indicative of a location of the IPCC, and to cause representations of the excavation machine and the IPCC to be simultaneously shown on the display based on the first and second signals. The at least one controller may also be configured to determine a swing radius of the work tool, and to selectively cause an indication of alignment between the IPCC and the swing radius to be shown on the display based on the first signal, the second signal, and the swing radius. 1. An excavation system for use with an excavation machine having a work tool and with an IPCC , the excavation system comprising:a location device mountable onboard the excavation machine and configured to generate a first signal indicative of a location of the excavation machine;a display; and receive a second signal indicative of a location of the IPCC;', 'cause representations of the excavation machine and the IPCC to be simultaneously shown on the display based on the first and second signals;', 'determine a swing radius of the work tool; and', 'selectively cause an indication of alignment between the IPCC and the swing radius to be shown on the display based on the first signal, the second signal, and the swing radius., 'at least one controller in communication with the location device and the display, the at least one controller being configured to2. The excavation system of claim 1 , wherein the at least one controller is further configured to:receive a desired loading position on the swing radius for the IPCC; andselectively cause an indication of alignment between the IPCC and the desired loading ...

Handling Snack Food Chips

An apparatus for handling three-dimensionally curved snack food chips. The apparatus includes a first conveyor for conveying a series of the snack food chips on a conveying surface and an inverting station located at an output end of the first conveyor. The inverting station includes an inverter configured for transferring the snack food chips from an output end of the first conveyor into contact with an internal concave surface of the inverter. A drive system for the inverter is configured to move the internal concave surface downwardly to cause movement of the snack food chips downward from an upper portion to a lower portion of the internal concave surface. A depositing station is located and configured for depositing the snack food chips from the lower portion of the internal concave surface onto a second conveyor configured for receiving snack food chips from the depositing station and conveying them away. 1. A method of handling three-dimensionally curved snack food chips , the method comprising the steps of:a) providing a plurality of three-dimensionally curved snack food chips, each three-dimensionally curved snack food chip having a convex face and an opposite concave face;b) conveying, by a first conveyor extending along a conveying direction, a series of the snack food chips to an inverting station located at an output end of the first conveyor, the snack food chips in the series being aligned along the conveying direction, the first conveyor having a first upper conveying surface engaging the convex face of the snack food chips, and the opposite concave face of the snack food chips being upwardly oriented;c) at the inverting station, sequentially transferring the snack food chips in the series from the first conveyor to an inverter, the inverter comprising an internal concave surface having an upper portion and a lower portion, the snack food chips being transferred from the output end of the first conveyor into contact with the upper portion of the ...

High strength, high stress corrosion cracking resistant and castable al-zn-mg-cu-zr alloy for shape cast products

The present invention provides an Al—Zn—Mg—Cu casting alloy that provides high strength for automotive and aerospace applications and optimized stress corrosion cracking resistance in highly corrosive and tensile environments. The inventive alloy composition includes about 3.5 wt. % to about 5.5 wt. % Zn; about 1.0 wt. % to about 3.0 wt. % Mg; about 0.5 wt. % to about 1.2 wt. % Cu; less than about 1.0 wt. % Si; less than about 0.30 wt. % Mn; less than about 0.30 wt. % Fe; and a balance of Al and incidental impurities.

SYSTEM AND METHOD FOR COMPENSATING BINARY INLET BUFFERS DURING INLINE BUFFER DILUATION

Liquid blending systems and methods of blending liquids are provided. In particular, systems and methods for compensating binary inlet buffers during inline buffer dilution are provided. The systems and methods can provide blends of diluent, a first buffer concentrate containing a majority of a tempering component, and a second buffer concentrate containing a minority of a tempering component. The flow of the first buffer concentrate can be adjusted based upon the total amount of the tempering component being added to the blend through the first and second buffer concentrates. 1. A system for compensating binary inlet buffers during inline buffer dilution comprising:a. a first port adapted to receive a diluent;b. a second port adapted to receive a first buffer concentrate having a majority component;c. a third port adapted to receive a second buffer concentrate, said second buffer concentrate having a minority component that is the same as the majority component of the first buffer concentrate;d. a mixer having an inlet and an outlet;e. a first flow meter in communication with the outlet of the mixer;f. a second flow meter having an inlet in communication with the second port and an outlet in communication with the inlet of the mixer;g. a third flow meter having a third flow meter having an inlet in communication with the third port and an outlet in communication with the inlet of the mixer and an inlet;h. a property sensor in communication with the outlet of the mixer;i. a first pump having an inlet in communication with the first port and an outlet in communication with the inlet of the mixer;j. a second pump having an inlet in communication with the second port and an outlet in communication with the inlet of the second flow meter;k. a third pump having an inlet in communication with the third port and an outlet in communication with the inlet of the third flow meter; i) adjust the first pump based on the first flow meter;', 'ii) adjust the third pump based on ...

MULTI-STAGE ACCURATE BLENDING SYSTEM AND METHOD

An accurate blending system for blending first and second liquid components includes a first feed adapted to communicate with a supply of the first component and a second feed adapted to communicate with a supply of the second component. A shear blender is in communication with the first and second feeds. A first sensor is in communication with an outlet of the shear blender. A controller is in communication with the first sensor so that a first characteristic of a solution exiting the shear blender can be detected. The controller is also in communication with the second feed so that delivery of the second component to the shear blender can be controlled based upon the detected first characteristic. 1. An accurate blending system for blending first and second liquid components comprising:a) a first feed adapted to communicate with a supply of the first component;b) a second feed adapted to communicate with a supply of the second component;d) a shear blender in communication with the first and second feeds;e) a first sensor in communication with an outlet of the shear blender;f) a controller in communication with the first sensor so that a first characteristic of a solution exiting the shear blender can be detected, said controller also in communication with the second feed so that delivery of the second component to the shear blender can be controlled based upon the detected first characteristic.2. The accurate blending system of wherein the first claim 1 , second and third feeds include pumps.3. The accurate blending system of wherein the first claim 1 , second and third feeds include valves.4. The accurate blending system of wherein the first sensor is a conductivity sensor.5. The accurate blending system of wherein the first sensor is a pH sensor.6. The accurate blending system of wherein the first sensor is a near-infrared sensor.7. The accurate blending system of further comprising:g) a third feed adapted to communicate with a supply of a third liquid component ...

APPARATUS AND SYSTEM FOR A COMPACT ILLUMINATION DEVICE

A light emitting device is provided that is generally configured to have a compact shape and a broad pattern of light emission. An example light emitting apparatus may include: a redirector disposed about an axis, the redirector having a first end and a second end, where the first end is narrower than the second end, the redirector defining a cavity between the first end and the second end; a power source at least partially disposed within the cavity defined by the redirector; and a light source disposed around the first end of the redirector about the axis, where the light source is powered by the power source and is configured to project light substantially parallel to the axis, toward the second end of the redirector. The redirector may include a frustoconical shape. 1. A light emitting apparatus comprising:a redirector disposed about an axis, the redirector having a first end and a second end, wherein the first end is narrower than the second end, the redirector defining a cavity between the first end and second end;a power source receiving area at least partially disposed within the cavity defined by the redirector; anda light source disposed around the redirector proximate the first end of the redirector about the axis, wherein the light source is powered by a power source received within the power source receiving area and is configured to project light substantially parallel to the axis, toward the second end of the redirector.2. The light emitting apparatus of claim 1 , wherein the redirector comprises a frustoconical shape.3. The light emitting apparatus of claim 2 , wherein an outer surface of the frustoconical shape comprises a microstructure of a plurality of angled steps.4. The light emitting apparatus of claim 3 , wherein the plurality of angled steps are arranged concentrically about the axis and offset along a length of the axis to form the frustoconical shape.5. The light emitting apparatus of claim 1 , wherein the power source is received entirely ...

BREAKER MOTORIZED SECONDARY CONNECTOR - FIELD INSTALLABLE KIT

A circuit breaker installation including a frame assembly and a circuit breaker assembly is provided. The frame assembly includes a conductor assembly and the frame assembly defines an enclosed space. The frame assembly conductor assembly includes a primary contact assembly and a movable secondary contact assembly. The circuit breaker assembly is movably disposed in the frame assembly enclosed space. The contact assemblies are configurable electrical components. The configurable electrical components move between a connect configuration, a test configuration, and, a disconnect configuration. 2. The frame assembly secondary contact assembly of wherein:when said case assembly is in said connect configuration, said case assembly is adjacent to said frame assembly enclosed space rear side;when said case assembly is in said test configuration, said case assembly is adjacent said frame assembly enclosed space front side; andwhen said case assembly is in said disconnect configuration, said case assembly is between said first position and said second position.3. The frame assembly secondary contact assembly of wherein:when said case assembly is in said connect configuration, said case assembly is in said first position;when said case assembly is in said test configuration, said case assembly is in said second position; andwhen said case assembly is in said disconnect configuration, said case assembly is in said third position.4. The frame assembly secondary contact assembly of wherein:when said case assembly is in said connect configuration, said circuit breaker assembly is in said first position;when said case assembly is in said test configuration, said circuit breaker assembly is in said second position; andwhen said case assembly is in said disconnect configuration, said circuit breaker assembly is in said second position.5. The frame assembly secondary contact assembly of wherein:said carriage assembly including a first actuator and a second actuator;said carriage ...

Packaging Snack Food Chips

A method of packaging snack food chips, the method comprising the steps of: (a) providing a plurality of snack food chips as a shingled assembly of the snack food chips; (b) enclosing the shingled assembly within an elongate packaging container; (c) vibrating the shingled assembly supported so as to cause the snack food chips sequentially to fall from a free output end into the elongate packaging container while progressively translationally separating a closed end and the free output end to form a shingled stack extending away from the closed end; and (d) during at least a part of step (c), rotating the elongate packaging container so that the closed end while decreasing an angle of inclination such that the shingled stack is being progressively formed.

CHROMATOGRAPHY AND SYNTHESIS COLUMN APPARATUS AND METHOD OF ASSEMBLY

Chromatography and synthesis columns, assemblies, components, and methods of assembly and disassembly are disclosed including a support assembly having lifting mechanisms in each of the legs to raise and lower a frame secured to the column, a swing arm and/or carriage guiding movement of a bottom plate of the column, a bolt-free coupling between the main tube and bottom plate of the column, and upper and lower slurry ports in the main tube of the column. 1. A base assembly for a chromatography column having a main tube and a bottom plate , the base assembly comprising:a frame secured to the main tube of the chromatography column;legs mounted to the frame to support the chromatography column in an upright orientation; andlifting mechanisms of each of the legs configured to raise and lower the frame.2. The base assembly of claim 1 , wherein each of the legs comprise a base claim 1 , and the lifting mechanisms comprise hydraulic cylinders claim 1 , each hydraulic cylinder supported by the base with a portion thereof engaging the frame.3. The base assembly of claim 2 , wherein the frame comprises tubular leg portions extending downwardly toward the bases of the legs claim 2 , the hydraulic cylinders extending within the tubular leg portions claim 2 , and the legs further comprise an upstanding wall extending around a perimeter of the base claim 2 , the upstanding wall configured to telescope with the tubular leg portions as the hydraulic cylinders move the frame.4. The base assembly of claim 3 , wherein the legs further comprise one or more bearings configured to orient the hydraulic cylinders within the tubular leg portions of the frame.5. The base assembly of claim 2 , wherein the hydraulic cylinders comprise double acting claim 2 , double rod cylinders connected in series claim 2 , and further comprising a control circuit configured to control operation of the hydraulic cylinders.6. The base assembly of claim 5 , wherein the control circuit comprises an air driven ...

MEDIUM VOLTAGE BREAKER CONDUCTOR WITH AN ELECTRICALLY EFFICIENT CONTOUR

The present disclosure provides a conductive member for a circuit breaker high voltage portion conductor assembly, the conductive member including a body with a transfer portion and a coupling portion. The body transfer portion has an electro-thermally efficient contour. That is, the body transfer portion has an electrically efficient contour and a thermally efficient contour. The body transfer portion includes a number of slots defining fins. In this configuration, the body transfer portion distributes current generally evenly across a cross-sectional area of the conductive member body. Further, the fins provide heat dissipation via convection. 1. A conductive member for a circuit breaker high voltage portion conductor assembly , said conductive member comprising:a body;said body includes a transfer portion and a coupling portion; andwherein said body transfer portion has an electrically efficient contour.2. The conductive member of wherein:wherein said body transfer portion also has a thermally efficient contour; andwhereby said body transfer portion has an electro-thermally efficient contour.3. The conductive member of wherein said body transfer portion includes a number of slots extending through said body transfer portion.4. The conductive member of wherein:each slot extends generally vertically through said body transfer portion;wherein said slots define a number of fins;wherein said number of fins includes a number of inner fins, each inner fin disposed between adjacent slots; andwherein said number of fins includes two outer fins, each outer fin disposed between a slot and the adjacent outer lateral side of body transfer portion.5. The conductive member of wherein:said body transfer portion includes a centerline;each fin has a thickness; andwherein each said fin thickness increases the further a fin is from said body transfer portion centerline.6. The conductive member of wherein:said number of fins includes a number of sets of fins; andeach fin in a set of ...

Systems and Methods of Reducing Virus Migration Through A Virus Removal Filter After Feed Flow Reduction

A valve arrangement for reducing the migration of one or more viruses through a filter when feed flow to the filter is resumed after a reduction in the feed flow. The valve arrangement includes an inlet line having an inlet port to be connected to a supply of product and an outlet port to be connected to an inlet of the filter, a pump, an outlet line, and a recirculation system. The recirculation system includes a recirculation line connecting the outlet line and the inlet line, and a check valve disposed along the recirculation line. When the check valve detects the feed flow reduction, a recirculation loop is created such that product is continuously recirculated through the filter during the reduction, thereby ensuring continuous fluid flow through the filter even during the reduction.

RESOURCE ALLOCATION FOR DATABASE PROVISIONING

A method of pre-allocating resources for database provisioning in a private cloud may include determining characteristics of a plurality of databases in a customer's database system. The method may also include grouping the characteristics of the plurality of databases to generate a plurality of database templates that are descriptive of the plurality of databases. The method may additionally include causing resources to be pre-allocated in the private cloud based on at least some of the plurality of database templates. The method may further include receiving a selection of a database template from the plurality of database templates as part of a provisioning request. The method may also include causing a database described at least in part by the database template to be provisioned in the private cloud. 1. A method of pre-allocating resources for database provisioning in a private cloud , the method comprising:determining characteristics of a plurality of databases in a customer's database system;grouping the characteristics of the plurality of databases to generate a plurality of database templates that are descriptive of the plurality of databases;causing resources to be pre-allocated in the private cloud based on at least some of the plurality of database templates;receiving a selection of a database template from the plurality of database templates as part of a provisioning request; andcausing a database described at least in part by the database template to be provisioned in the private cloud.2. The method of claim 1 , wherein the characteristics of the plurality of databases comprise an operating system type and version.3. The method of claim 1 , wherein the characteristics of the plurality of databases comprise a database type and version.4. The method of claim 1 , wherein the characteristics of the plurality of databases comprise a database memory size.5. The method of claim 1 , wherein the characteristics of the plurality of databases comprise processor ...

USER INTERFACES FOR SHARING CONTEXTUALLY RELEVANT MEDIA CONTENT

The present disclosure generally relates to managing and sharing contextually-relevant media content. In some embodiments, a device receives an input, and in response, displays a suggested collection of media items for sharing with a recipient, wherein the collection is relevant to a message conversation with the recipient. Subsequent to displaying the suggested collection, the device transmits a message to the recipient as part of the message conversation that provides access to the at least a portion of the suggested collection of media items. In some embodiments, a device receives an indication, from an external device, that a first user has shared a first collection of media items with a second user. Subsequent to receiving the indication that the first user has shared the first collection of media items with the second user, the device outputs a prompt to share, with the first user, one or more suggested media items. 1. An electronic device , comprising:a display;one or more input devices;one or more processors; and receiving, via the one or more input devices, a first input;', 'in response to receiving the first input, displaying, on the display, a suggested collection of media items for sharing with a recipient, wherein the suggested collection is relevant to a message conversation with the recipient;', 'subsequent to displaying the suggested collection of media items, receiving, via the one or more input devices, a second input representing a request to transmit at least a portion of the suggested collection of media items to the recipient; and', 'in response to receiving the second input, transmitting a message to the recipient as part of the message conversation that provides access to the at least a portion of the suggested collection of media items., 'memory storing one or more programs configured to be executed by the one or more processors, the one or more programs including instructions for2. The electronic device of claim 1 , the one or more programs ...

SHARING CONTENT IN A MESSAGING APPLICATION

A device implementing a system for sharing groups of files within a messaging application includes a processor configured to provide, within the messaging application, a user interface element for sending at least one file to a participant in an active message thread of the messaging application, the at least one file having been determined to be relevant to the participant. The processor is further configured to, responsive to receiving a selection of the user interface element: transmit, to a server, a request to store the at least one file in association with a shared storage area, and to transmit, via the messaging application, a message to the participant in the active message thread, the message comprising information for accessing the at least one file associated with the shared storage area. 1. A device , comprising:at least one processor; and provide, within a messaging application, a user interface element for sending at least one file to a participant in an active message thread of the messaging application, the at least one file having been determined to be relevant to the participant; and', transmit, to a server, a request to store the at least one file in association with a shared storage area; and', 'transmit, via the messaging application, a message to the participant in the active message thread, the message comprising information for accessing the at least one file associated with the shared storage area., 'responsive to receiving a selection of the user interface element], 'a memory including instructions that, when executed by the at least one processor, cause the at least one processor to2. The device of claim 1 , wherein the information for accessing the at least one file associated with the shared storage area comprises a Uniform Resource Locator (URL).3. The device of claim 2 , wherein the URL references the shared storage area for access of the at least one file.4. The device of claim 2 , wherein the URL is transmitted with a hash string for ...

DEVICES AND METHODS FOR LOCAL DELIVERY OF TACROLIMUS OR DERIVATIVES THEREOF

Devices for local delivery of tacrolimus or a derivative thereof are provided, wherein the devices comprise a polymeric matrix containing tacrolimus or a derivative thereof that provides for delayed and extended release of tacrolimus or a derivative thereof. The devices can locally deliver tacrolimus or a derivative thereof to injured nervous system tissue upon implantation in a subject. Thus, techniques for local delivery of tacrolimus or a derivative thereof and methods of treatment using such devices are also provided. 1. A device for local delivery of tacrolimus or a derivative thereof , comprising a polymeric matrix comprising a biodegradable polymer and tacrolimus or a derivative thereof.2. The device of claim 1 , wherein the biodegradable polymer comprises poly(ester urethane) urea.3. The device of claim 1 , wherein the biodegradable polymer has a number average molecular weight of from about 40 claim 1 ,000 Da to about 200 claim 1 ,000 Da.4. The device of claim 1 , wherein the device is configured as a sheet.5. The device of claim 1 , further comprising an attachment mechanism for securing the device to nervous system tissue.6. The device of claim 1 , wherein the device has a Young's modulus of from about 15 MPa to about 30 MPa.7. The device of claim 1 , wherein the device has an ultimate stress of at least about 5 MPa.8. The device of claim 1 , wherein the device has a strain at break of from about 150% to about 300%.9. The device of claim 1 , wherein the tacrolimus or derivative thereof is present in an amount of from about 1 mg to about 100 mg.10. The device of claim 1 , wherein the biodegradable polymer and the tacrolimus or derivative thereof are present in a weight ratio of from about 1:50 to about 1:20.11. A method for local delivery of tacrolimus or a derivative thereof to a nervous system tissue in a subject claim 1 , comprising applying a polymeric matrix comprising poly(ester urethane) urea and tacrolimus or a derivative thereof to an implantation ...

ANATOMICAL EXTRACTION DEVICE

A medical extraction device comprising: (a) a sheath including a distal end configured to be inserted into a patient and a proximal end configured to be retained exteriorly of the patient; (b) a basket configured to extend from a distal end of the sheath and be repositionable between an expanded position and a retracted position, the basket including at least three loops, the basket also including a first guide and a second guide, where the first guide receives portions of the first loop and the third loop, where the second guide receives portions of the first loop and the second loop, where the second loop and the third loop are fixedly mounted to one another at a location interposing the first guide and the second guide; and, (c) a handle control operatively coupled to a proximal end of the sheath and being operatively coupled to the basket, the handle control configured facilitate repositioning of the basket with respect to the sheath between the retracted position and the expanded position. 1. A medical extraction device comprising: a first guide and a second guide circumscribed by the hollow sheath;', 'a first loop, a second loop, and a third loop, where the first loop extends between the first and second guides;', 'a first anchor fixing a relative position of a distal portion of the second loop with respect to a distal portion of the third loop;', 'a first joint coupling the second loop and the third loop proximal to the first anchor;', 'a second anchor fixing a relative position of a distal portion of the first loop with respect to a portion of the first guide;', 'a line operatively coupled to proximal portions of at least two of the first, second, and third loops so that repositioning of the line is operative to at least one of increase and decrease the length of at least two of the first, second, and third loops extending from the distal end., 'a hollow sheath including a distal end from which a basket may extend in an expanded position, the basket ...

Systems and Methods for Testing the Integrity of a Virus Removal Filter

A single-use valve arrangement that includes a valve housing, a diaphragm carried by the valve housing, a pressure sensor, and a controller coupled to the pressure sensor. The valve housing defines an inlet and an outlet, the inlet adapted to be fluidly connected to an outlet of a virus removal filter. The diaphragm divides the valve housing into a first chamber and a second chamber fluidly isolated from the first chamber. The pressure sensor is configured to measure a pressure change in the second chamber due to movement of the diaphragm responsive to a pressure change in the first chamber. The controller is configured to determine an actual leak rate of the filter based on the measured pressure change, the controller further configured to determine the integrity of the filter by comparing the actual leak rate to an expected leak rate of the filter. 1. A valve arrangement for testing the integrity of a virus removal filter , the valve arrangement comprising:a valve housing defining an inlet and an outlet, the inlet adapted to be fluidly connected to an outlet of the virus removal filter;a diaphragm carried by the valve housing, wherein the diaphragm divides the valve housing into a first chamber and a second chamber fluidly isolated from the first chamber, the first chamber in fluid communication with both the inlet and the outlet, and wherein the diaphragm is movable responsive to a pressure change in the first chamber;a pressure sensor in fluid communication with the second chamber, the pressure sensor configured to measure a pressure change in the second chamber due to movement of the diaphragm responsive to the pressure change in the first chamber; anda controller coupled to the pressure sensor and configured to determine an actual leak rate of the virus removal filter based on the measured pressure change, the controller further configured to determine the integrity of the virus removal filter by comparing the actual leak rate to an expected leak rate of the ...

Anti-cxcr5 antibodies and methods of use

The invention provides novel anti-CXCR5 antibodies and methods of using the same.

Antibodies against IL-18R1 and their uses

Anticuerpo aislado ligante de IL-18R1 humana y caracterizado por que comprende como las CDR de región variable de cadena pesada una región CDRH1 de secuencia SEC ID nº 2 ó SEC ID nº 10, una región CDRH2 de secuencia SEC ID nº 3 y una región CDRH3 de secuencia SEC ID nº 4, y como CDR de región variable de cadena ligera, una región CDRL1 de secuencia SEC ID nº 6, una región CDRL2 de secuencia SEC ID nº 7 y una región CDRL3 de secuencia SEC ID nº 8. Isolated human IL-18R1 binding antibody and characterized in that it comprises as the heavy chain variable region CDRs a CDRH1 region of sequence SEQ ID No. 2 or SEQ ID No. 10, a CDRH2 region of sequence SEQ ID No. 3 and a CDRH3 region of sequence SEQ ID No. 4, and as a light chain variable region CDR, a CDRL1 region of sequence SEQ ID No. 6, a CDRL2 region of sequence SEQ ID No. 7 and a CDRL3 region of sequence SEQ ID No. 8.

Antibodies against il-18r1 and uses thereof

The invention provides anti-IL-18R1 antibodies and methods of using the same.

MONOCLONAL ANTICOERPER AGAINST MELANOMA

processing arrangement

Gemäß verschiedenen Ausführungsformen kann eine Prozessieranordnung (100) Folgendes aufweisen: eine Prozesskammer (102) zum Prozessieren eines Substrats innerhalb eines Prozessierbereichs (111); ein Wandelement (104), welches den Prozessierbereich (111) zumindest teilweise begrenzt, wobei das Wandelement (104) derart angeordnet und derart gasdurchlässig strukturiert ist, dass es, wenn es mit einer Gasversorgung gekuppelt ist, mit Gas durchströmt wird, wobei der Gasstrom (104g) durch das Wandelement (104) hindurch in Richtung des Prozessierbereichs (111) gerichtet ist. According to various embodiments, a processing assembly (100) may include: a process chamber (102) for processing a substrate within a processing region (111); a wall element (104) which at least partially delimits the processing region (111), wherein the wall element (104) is arranged and structured in a gas-permeable manner such that it flows through gas when it is coupled to a gas supply, the gas stream ( 104g) is directed through the wall element (104) in the direction of the processing region (111).

Afucosylated antibodies against ccr5 and their use

An antibody binding to CCR5 and being glycosylated with a sugar chain at Asn297, said antibody being characterized in that the amount of fucose within said sugar chain is 65 % or lower has improved properties in anti-inflammatory therapy.

Afucosylated antibodies against CCR5 and their use

APPARATUSES, SYSTEMS, AND METHODS FOR SAMPLE CAPTURE AND EXTRACTION

Methods, apparatuses, and systems associated with aerosol collection devices (such as, but not limited to, breath-aerosol collector devices, breathalyzers) are provided.

Control system for mining machine

A mining machine (100) such as a mining shovel includes a digging assembly (130) having an upward extending boom (122) and a dipper arm (134) generally horizontally supported by the boom (122) and configured to crowd toward and retract from a vertical bank (104) at a mine site. To determine if the dipper assembly (130) strikes the bank (104), an electronic controller (200) can calculate a calculated crowd force (272) based in part on a crowd motor torque (266) associated with a crowd motor (162), a crowd speed (264) of the dipper assembly (130), and an inertia parameter (274). If the calculated crowd force (272) exceeds a predetermined first crowd threshold (282), the electronic controller (200) can register an impact event (284). In further aspects, the electronic controller (200) can execute a force modification function (290) to modify the crowding forces and a speed reduction function (300) to reduce the crowd speed.

Antibodies against il-18r1 and uses thereof

The invention provides anti-IL-18R1 antibodies and methods of using the same.

Identification of human cell lines for the production of human proteins through endogenous gene activation

Patente de Invenção:<B>"IDENTIFICAçãO DE LINHAS DE CéLULAS HUMANAS PARA A PRODUçãO DE PROTEìNAS HUMANAS MEDIANTE ATIVAçãO DE GENES ENDóGENA"<D>. A invenção refere-se a processos para a escolha de células humanas para a preparação de proteínas humanas mediante ativação de gene endógena, para produzir proteínas humanas em rendimentos económicos e em uma forma, que é adequada para a preparação de uma preparado farmacêutico. Além disso, a invenção refere-se a um processo para a preparação de proteínas humanas em uma linha de células identificadas desta maneira.

Knock in transgenic mammal containing a non-functional n-terminus of kv beta 1.1 subunit

This invention provides a transgenic mammal containing a defective beta 1 subunit (Kvss1) of a voltage sensitive potassium channel, where the Kvss1 subunit is unable to confer N-type inactivation of the K+ but retains the ability to co-associate with Kv1 family a- subunits and thereby enhance channel surface expression. Preferably the Kvss1.1 gene encoding Kvss1 subun it has a mutation in all or a portion of codons 1-70 of its inactivation domain . The transgenic mammal is useful as a model for psychiatric and neurological disorders to identify anxiolytic compounds and pro-cognitive functions. The invention also provides for methods for screening and evaluating test compounds for their ability to modulate Kvss1.1 activity, specifically for inactivation of a potassium channel or for co-association with a-subunits.</ SDOAB>

Antibodies to CCR5 and uses thereof

SAMMENDRAG Et antistoff som binder til human CCR5 omfattende en variabel tung kjede og en variabel lett kjede, karakterisert ved at den variable tunge kjeden omfatter CDR-sekvensene CDR1, CDR2 og CDR3 og CDR1 er valgt fra gruppen bestående av SEKV ID NR: 9, 10, 11, 12, CDR2 er valgt fra gruppen bestående av SEKV ID NR: 13, 14, 15, CDR3 er valgt fra gruppen bestående av SEKV ID NR: 16, 17, hvor nevnte CDR'er er valgt uavhengig av hverandre eller er en kimær, humanisert variant eller et fragment av nevnte antistoff, har fordelaktige egenskaper for behandling av immunosuppressive sykdommer.

Foodstuffs packaging machine, has antenna for data exchange between transponder and computer- and/or control unit, where data are transmitted to transponder and are accessed from transponder by antenna

The machine has a labeler for attachment of a transponder (4) to a plastic package (2) and an antenna for data exchange between the transponder and a computer-and/or control unit. Data are transmitted to the transponder and are accessed from the transponder by the antenna. The package has a deep-drawn packaging tray (17), where packaging goods are inserted into the tray that is closed with a cover film (7).

Medium voltage breaker conductor with an electrically efficient contour

The present disclosure provides a conductive member for a circuit breaker high voltage portion conductor assembly, the conductive member including a body with a transfer portion and a coupling portion. The body transfer portion has an electro-thermally efficient contour. That is, the body transfer portion has an electrically efficient contour and a thermally efficient contour. The body transfer portion includes a number of slots defining fins. In this configuration, the body transfer portion distributes current generally evenly across a cross-sectional area of the conductive member body. Further, the fins provide heat dissipation via convection.

Packaging machine with a labeling device

Verpackungsmaschine mit einer Etikettierungsvorrichtung, die einen Etikettenspender (5) und einen Absetzkasten (4) aufweist, wobei der Etikettenspender (5) Etiketten (7) zur Verfügung stellt und der Absetzkasten die Etiketten (7) auf Verpackungen (2) anbringt, dadurch gekennzeichnet, dass während des Betriebs der Verpackungsmaschine der Etikettenspender (5) ortsfest angeordnet ist und nur der Absetzkasten (4) die Etiketten (7) über den Verpackungen (7) in und gegen eine Maschinenlaufrichtung (5) positioniert und anbringt, wobei der Etikettenspender (5) die Etiketten (7) an mehreren Übergabepunkten (8) an den Absetzkasten (4) übergibt und der Absetzkasten (4) die Etiketten (7) über den Verpackungen (2) positioniert. Packaging machine with a labeling device comprising a label dispenser (5) and a depositing box (4), the label dispenser (5) providing labels (7) and the depositing box applying the labels (7) to packages (2), characterized in that the label dispenser (5) is stationary during operation of the packaging machine and only the settling box (4) positions and attaches the labels (7) over the packages (7) in and against a machine direction (5), the label dispenser (5) the labels (7) at several transfer points (8) passes to the settling box (4) and the settling box (4) positions the labels (7) over the packages (2).

Treatment of pain.

La presente invencion se refiere a un metodo para tratamiento de dolor en un mamifero que incluye administrar a un mamifero en necesidad de tal tratamiento una cantidad efectiva para tratamiento de dolor de un compuesto de la formula I: o una sal del mismo farmaceuticamente aceptable, en donde cada uno de R1, R2, R3, n, y, y Ar es como se definio y describio en la presente. La presente invencion tambien proporciona composiciones farmaceuticas para el tratamiento del dolor que contiene una cantidad efectiva para tratamiento de dolor del compuesto de la formula.

PEG conjugates of HGT-NK4

Monoclonal anti-il-1racp antibodies

Monoclonal antibody that specifically binds the interleukin 1 receptor type 1 (IL-1RAcP), or an antigen binding fragment thereof, comprising: a) a heavy chain variable region (VH) comprising CDR1H, CDR2H and/or CDR3H, wherein the CDR1H region comprises an amino acid sequence selected from the group of SEQ ID NO: 155 - 231, wherein the CDR2H region comprises an amino acid sequence selected from the group of SEQ ID NO: 232 - 308, and wherein the CDR3H region comprises an amino acid sequence selected from the group of SEQ ID NO: 309 - 385; and b) a light chain variable region (VL) comprising CDR1L, CDR2L and/or CDR3L, wherein the CDR1L region comprises an amino acid sequence selected from the group of SEQ ID NO: 386 - 462, wherein the CDRL2 region comprises an amino acid sequence selected from the group of SEQ ID NO: 463 - 539, and wherein the CDR3L region comprises an amino acid sequence selected from the group of SEQ ID NO: 540 - 616 The monoclonal antibody is characterized in that it inhibits IL-1RAcP induced NFkB activity, useful in treatment of IL-1RAcP related diseases.

Systems and methods of reducing virus migration through a virus removal filter after feed flow reduction

A valve arrangement for reducing the migration of one or more viruses through a filter when feed flow to the filter is resumed after a reduction in the feed flow. The valve arrangement includes an inlet line having an inlet port to be connected to a supply of product and an outlet port to be connected to an inlet of the filter, a pump, an outlet line, and a recirculation system. The recirculation system includes a recirculation line connecting the outlet line and the inlet line, and a check valve disposed along the recirculation line. When the check valve detects the feed flow reduction, a recirculation loop is created such that product is continuously recirculated through the filter during the reduction, thereby ensuring continuous fluid flow through the filter even during the reduction.

Pharmaceutical compositions for intranasal administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.o]non-1 (7)-en-2-yl)alkyl] phosphonic acid and derivatives and methods of use thereof

Pharmaceutical compositions for intranasal administration are provided that contain at least one compound of formula (I) or a pharmaceutically acceptable salt thereof: and one or more pharmaceutically acceptable additives for forming a composition for intranasal administration. Also provided are methods of treating one or more conditions in a mammal associated with a glutamate abnormality that includes administering intranasally to a mammal a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof.

Antibodies against ccr5 and uses thereof

An antibody binding to human CCR5 comprising a variable heavy chain and a variable light chain, characterized in that the variable heavy chain comprises CDR sequences CDRl, CDR2 and CDR3 and CDRl being selected from the group consisting of SEQ ID NOs: 9, 10, 11, 12, CDR2 being selected from the group consisting of SEQ ID NOs: 13, 14, 15, CDR3 being selected from the group consisting of SEQ ID NOs: 16, 17, wherein said CDRs are selected independently of each other, or is a chimeric, humanized variant or a fragment of said antibody, has advantageous properties for the treatment of immunosuppressive diseases.

[[2-(amino-3,4-dioxo-1cyclobuten-1-yl)amino]alkyl]-acid derivatives for the treatment of pain

This invention provides a method of treating pain in a mammal that includes administering to a mammal in need of such treatment a pain treating effective amount of a compound of the formula (I): where R1 is H, alkyl or phenylalkyl; R2 is H, alkyl, alkenyl or phenylalkyl; or R1 and R2 taken together as Z are .mdash.CH2C-H2.mdash., .mdash.CH2C(R6)(R7)CH2.mdash. or .mdash.CH2C(R8)(R9).mdash.C(R10)(R11)CH2.mdash., where R6, R8 and R10 are, independently, H, alkyl or hydroxyl and R7, R9 and R11 are, independently, H or alkyl; A is alkylene or alkenylene; X is CO2R3, P(O)(OR4)(OR5), 3, 5-dioxo-1,2,4-oxadiazolidin-2-yl or 5-tetrazolyl in which R3, R4 and R5 are, independently, H or alkyl, or a pharmaceutical compositions for treating pain containing a pain treating effective amount of the compound of formula(I).

Blade holder tool for cutting a pour spout

Oral administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl]phosphonic acid and derivatives

Heat treatable al-zn-mg-cu alloy for aerospace and automotive castings

A heat treatable aluminum alloy for shaped castings includes from about 3.5-5.5% Zn, from about 1-3% Mg, about 0.05-0.5% Cu, and less than about 1% Si.

Antibodies against ccr5 and uses thereof

An antibody binding to CCR5 characterized in that the heavy chain variable domain comprises an amino acid sequence of SEQ ID NO: 1, and has advantageous properties for the treatment of immunosuppressive diseases.

Humanized anti-il-1r3 antibodies

Afucosylated antibodies against ccr5 and their use

An antibody binding to CCR5 and being glycosylated with a sugar chain at Asn297, said antibody being characterized in that the amount of fucose within said sugar chain is 65 % or lower has improved properties in anti-inflammatory therapy.

Identification of human cell lines for the production of human proteins by endogenous gene activation

The invention relates to methods for the selection of human cells for the preparation of human proteins by endogenic gene activation in order to produce human proteins in economical yields and in a form which is suitable for the production of a pharmaceutical preparation. The invention furthermore relates to a method for the production of human proteins in a cell line identified in this manner.

Monoclonal antibody against melanoma

Heat-treated Al-Zn-Mg alloy for stuffing for the aviation and automotive industry

Varmebehandlebar aluminiumslegering for formede avstøp innbefattende fra omtrent 3,5-5,5% Zn, fra omtrent 1-3% Mg, omtrent 0,05 til 0,5% Cu og mindre enn omtrent 1% Si.

2-(2,6-Dichlorophenyl)-diarylimidazoles.

VR1 BENCIMIDAZOLIC MODULARS

La invencion se refiere a compuestos de Formula (I): a composiciones farmaceuticas que contienen tales compuestos y a metodos de tratamiento para utilizarlos.

2- (2,5-DICLOROPENIL) -DIARILIMIDAZOLES.

Un compuesto de la fórmula general (I) en la que X es hidrógeno; OR1; SR2; (SO)R2; (SO2)R2; o un grupo A1-Q; A1 significa un grupo alquileno C1-C3; Q es OR1; SR2; SOR2; SO2R2; NR3R4; NHCH2CH2NR3R4 o halógeno; R1 se elige entre el grupo formado por hidrógeno; alquilo C1-C3; alilo; dimetilfosfonilmetilo; 2, 3-epoxi-1-propilo; (R)-2, 3-dihidroxi-1-propilo; (S)-2, 3-dihidroxi-1-propilo; 1, 3-dihidroxi-2-propilo; 3-hidroxi-2-hidroximetil-1-propilo; 2-metoxietoximetilo; 2, 2-dimetil-1, 3-dioxolan-4-ilmetilo o un grupo A1-Q1; Q1 significa alcoxi C1-C2; ciano; carboxilo; (alcoxi C1-C6)-carbonilo; carboxamida; -CO-NR3R4; alquil C1-C6-sulfanilo; alquil C1-C6-sulfenilo; alquil C1-C6-sulfonilo y en el caso de que A1 signifique un grupo 1, 2-etileno o 1, 3-propileno, Q1 es hidroxi o NR3R4; R2 es alquilo C1-C6; dimetilfosfonilmetilo; 2, 3-epoxi-1-propilo; 2, 3-dihidroxi-1-propilo; 2, 2-dimetil-1, 3-dioxo-lan-4-ilmetilo o A1-Q1; R3, R4 se eligen con independencia entre el grupo formado por hidrógeno; alquilo C1-C6 o forman, juntos, un anillo saturado o insaturado de 5 a 7 eslabones, sustituido opcionalmente por un grupo metilo y que contiene uno o dos heteroátomos, elegidos con independencia entre N y O; Y es hidrógeno o un grupo A2-R; A2 es alquileno C1-C5, que puede estar opcionalmente sustituido por alquilo C1-C6; fenilo o por hidroxi; R significa hidroxi; alcoxi C1-C6 lineal o ramificado; amino; dimetilamino; dietilamino; t-butiloxicarbonilamino; carboxilo; (alcoxi C1-C6)-carbonilo; triazolilo; ciano; piperidino; 1-pirrolidinilo; morfolino; 4-metilpiperazin-1-ilo; O-A1-NR3R4; S-A1-NR3R4; 4-carboxifenilo; furan-3-ilo; tiofen-2-ilo o 3-metiltiofen-2-ilo; Z significa uno o dos sustituyentes elegidos con independencia entre el grupo formado por halógeno; hidroxi; aliloxi; metilo; alcoxi C1-C5; metoximetoxi; (2-metoxietoxi)metiloxi; metiltio; etoximetoxi; metilendioxi; etinilo; trimetilsililetinilo y benciloxi que está opcionalmente sustituido por halógeno; metoxi; ciano; nitro; ...

Benzimidazole modulators of vr1

The invention is directed to compounds of Formula (I): to pharmaceutical compositions containing such compounds and to methods of treatment using them.

Gas generating device and related method

Antibodies against ccr5 and uses thereof.

Un anticuerpo que se une al CCR5 humano formado por una cadena pesada variable y una cadena ligera variable, que se caracteriza en que la cadena pesada variable consta de las secuencias CDR, CDR1, CDR2 y CDR3 y siendo la CDR1 selecciona de un grupo formado por los SEC ID NO:9, 10, 11, 12; siendo la CDR2 seleccionada de un grupo formado por los SEC ID NO:13, 14, 15; y siendo la CDR3 seleccionada de un grupo formado por los SEC ID NO:16, 17, donde dichas CDR se seleccionan independientemente de cada una, o es una variante humanizada, quimerica o un fragmento del anticuerpo y tiene unas propiedades ventajosas para el tratamiento de las enfermedades inmunosupresoras.

User interfaces for sharing contextually relevant media content

The present disclosure generally relates to managing and sharing contextually-relevant media content. In some embodiments, a device receives an input, and in response, displays a suggested collection of media items for sharing with a recipient, wherein the collection is relevant to a message conversation with the recipient. Subsequent to displaying the suggested collection, the device transmits a message to the recipient as part of the message conversation that provides access to the at least a portion of the suggested collection of media items. In some embodiments, a device receives an indication, from an external device, that a first user has shared a first collection of media items with a second user. Subsequent to receiving the indication that the first user has shared the first collection of media items with the second user, the device outputs a prompt to share, with the first user, one or more suggested media items.

Monoclonal antibodies directed against eca and the use thereof

ABSTRACT Monoclonal antibodies directed against ECA and the use thereof The present invention provides a process for the production or antibodies directed against Entero-bacteriaceae, wherein B-lymphocytes are obtained from the blood of donors in whom an Enterobacteriaceae infection has been detected, the lymphocytes are immortalised, the cells which produce antibodies with the desired activity are selected, cultured and the antibodies obtained therefrom. The present invention also provides medicaments containing antibodies produced by this process. The antibodies can be used for passive immunisation against infections brought about by Enterobacteriaceae and for the qualitative and quantitative detection of Entero-bacteriaceae.