17-05-2018 дата публикации
Номер: US20180133283A1
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Methods and compositions for synchronizing the time of insemination in gilts are provided. More particularly, methods and compositions for synchronizing the time of insemination in gilts using a gonadotropin-releasing hormone and a hormone for synchronizing estrus are provided. 1. A method for synchronizing time of insemination in a gilt , the method comprising the steps of:administering to the gilt a hormone for synchronizing estrus;administering to the gilt a single dose of a gonadotropin-releasing hormone for synchronizing ovulation, without administration of any other hormone for synchronizing ovulation, wherein the gonadotropin-releasing hormone is administered on the fifth day after the last daily administration of the hormone for synchronizing estrus; andinseminating the gilt, without monitoring estrus, only one time on the sixth day after the last daily administration of the hormone for synchronizing estrus.3. The method according to wherein the gonadotropin-releasing hormone is selected from the group consisting of compounds of the formula of wherein{'sup': 1', '2', '5', '1, 'sub': 2', '2, 'a) Ris 1H-indol-3-yl-methyl, Ris hydrogen, X is CH(CO)NH; Ris hydrogen; and the configuration of the carbon to which Ris attached is R;'}{'sup': 1', '2', '5, 'sub': 2', '2, 'b) Ris hydrogen, Ris hydrogen, X is CH(CO)NH; and Ris hydrogen;'}{'sup': 1', '2', '5, 'c) Ris 1H-1-benzyl-imidazol-4-yl-methyl, Ris hydrogen, X is ethyl; and is hydrogen;'}{'sup': 1', '2', '5, 'd) Ris 2-methylpropyl, Ris hydrogen, X is ethyl; and Ris hydrogen;'}{'sup': 1', '2', '5, 'sub': 2', '2, 'e) Ris 2-naphthylmethyl, Ris hydrogen, X is CH(CO)NH; and Ris hydrogen;'}{'sup': 1', '2', '5', '1, 'f) Ris t-butoxymethyl, Ris hydrogen, X is ethyl; Ris hydrogen; and the configuration of the carbon to which Ris attached is R;'}{'sup': 1', '2', '5', '1, 'sub': 2', '2, 'g) Ris benzyl, Ris hydrogen, X is CH(CO)NH; Ris hydrogen; and the configuration of the carbon to which Ris attached is R;'}{'sup': 1', '2', ...
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