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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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16-02-2012 дата публикации

Process for the production of ethanol and butanol

Номер: US20120040427A1
Автор: Bell Peter Simpson, Benstead Stephen John, Turnbull Neil
Принадлежит:

The present invention relates to a process for the production of ethanol and butanol from biomass, and in particular to a process for the production of ethanol and butanol using two separate fermentation steps, said process comprising: a) passing a biomass feedstock to a first fermentation step, b) in said first fermentation step subjecting the biomass feedstock to anaerobic fermentation at a pH below 6.0 and at a temperature in the range 20 to 700° C. and so as to convert the biomass to a product predominantly comprising acetic acid and butyric acid with at least a 2:1 ratio by weight of acetic acid to butyric acid, c) treating the product stream of step (b) to separate a solution comprising the acetic acid and butyric acid by: (i) separating a solution comprising the acetic acid and butyric acid from any residual solids and (ii) separating bacteria and/or pasteurising or sterilising the solution from the first fermentation step, and d) in a second fermentation step fermenting the solution comprising the acetic acid and butyric acid from step (c) to form ethanol and butanol. 1. A process for the production of ethanol and butanol using two separate fermentation steps , said process comprising:a) passing a biomass feedstock to a first fermentation step,b) in said first fermentation step subjecting the biomass feedstock to anaerobic fermentation at a pH below 6.0 and at a temperature in the range 20 to 70° C. and so as to convert the biomass to a product predominantly comprising acetic acid and butyric acid with at least a 2:1 ratio by weight of acetic acid to butyric acid, (i) separating a solution comprising the acetic acid and butyric acid from any residual solids and', '(ii) separating bacteria and/or pasteurising or sterilising the solution from the first fermentation step,', 'and, 'c) treating the product stream of step (b) to separate a solution comprising the acetic acid and butyric acid byd) in a second fermentation step fermenting the solution comprising the ...

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Номер записи: 1
29-03-2012 дата публикации

ADVANCED CONTINUOUS ANALYTE MONITORING SYSTEM

Номер: US20120078071A1
Автор: Bohm Sebastian, Dervaes Mark, JOHNSON Eric, Kamath Apurv Ullas, Larvenz Shawn, Leach Jacob S., Lieu Phong, Mahalingam Aarthi, Miller Tom, Neale Paul V., Peyser Thomas A., Pryor Jack, Rong Daiting, San Vicente Kenneth, Shariati Mohammad Ali, Simpson Peter C., Wightlin Matthew
Принадлежит: DexCom, Inc.

Systems and methods for processing, transmitting, and displaying data received from a continuous analyte (e.g., glucose) sensor are provided. A sensor system can comprise a sensor electronics module that includes power saving features, e.g., a low power measurement circuit that can be switched between a measurement mode and a low power mode, wherein charging circuitry continues to apply power to electrodes of a sensor during the low power mode. The sensor electronics module can be switched between a low power storage mode and a higher power operational mode via a switch, e.g., a reed switch or optical switch. A validation routine can be implemented to ensure an interrupt signal sent from the switch is valid. The sensor can be physically connected to the sensor electronics module in direct wireless communication with a plurality of different display devices. 1. A system for continuous measurement of an analyte in a host , the system comprising:a continuous analyte sensor; anda sensor electronics module coupled to the sensor, the sensor electronics module comprising measurement circuitry, power circuitry, and charging circuitry,wherein the sensor electronics module is configured to switch between a first mode and a second mode,wherein in the first mode the power circuitry is coupled to the measurement circuitry and the charging circuitry, the measurement circuitry is coupled to the continuous analyte sensor, and the charging circuitry is decoupled from the continuous analyte sensor, andwherein in the second mode the power circuitry is decoupled from the measurement circuitry and the charging circuitry, the measurement circuitry is decoupled from the continuous analyte sensor, and the charging circuitry is coupled to the continuous analyte sensor.2. The system of claim 2 , wherein the sensor comprises a plurality of electrodes.3. The system of claim 3 , wherein the measurement circuitry applies a voltage across the electrodes of the sensor during the first mode and the ...

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Номер записи: 2
26-07-2012 дата публикации

INTEGRATED DELIVERY DEVICE FOR CONTINUOUS GLUCOSE SENSOR

Номер: US20120186581A1
Автор: Brauker James H., Kamath Apurv U., Markovic Dubravka, Mensinger Michael Robert, Neale Paul V., Saint Sean T., Simpson Peter C., Tapsak Mark A.
Принадлежит: DexCom,Inc.

Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction. 1. An integrated system for monitoring and treating diabetes , the system comprising:a glucose sensor, wherein the glucose sensor substantially continuously measures glucose in a host for a period exceeding one hour, and outputs a data stream, including one or more sensor data points;a receiver operably connected to the glucose sensor, wherein the receiver is configured to receive the data stream; anda medicament delivery device, wherein the delivery device is physically detachably connectable to the receiver, wherein at least one of the receiver and the medicament delivery device comprises programming that automatically detects impending clinical risk and calculates a therapy recommendation responsive to the impending clinical risk, and wherein the at least one of the receiver and the medicament delivery device further comprises programming that requires the at least one of the receiver and the medicament delivery device to be at least one of validated and confirmed by a user interaction in response to a prompt ...

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Номер записи: 3
13-09-2012 дата публикации

ELECTRODE SYSTEMS FOR ELECTROCHEMICAL SENSORS

Номер: US20120228134A1
Автор: Brauker James H., Carr-Brendel Victoria E., Petisce James R., Simpson Peter C.
Принадлежит: DexCom, Inc.

The present invention relates generally to systems and methods for improved electrochemical measurement of analytes. The preferred embodiments employ electrode systems including an analyte-measuring electrode for measuring the analyte or the product of an enzyme reaction with the analyte and an auxiliary electrode configured to generate oxygen and/or reduce electrochemical interferants. Oxygen generation by the auxiliary electrode advantageously improves oxygen availability to the enzyme and/or counter electrode; thereby enabling the electrochemical sensors of the preferred embodiments to function even during ischemic conditions. Interferant modification by the auxiliary electrode advantageously renders them substantially non-reactive at the analyte-measuring electrode, thereby reducing or eliminating inaccuracies in the analyte signal due to electrochemical interferants. 1. An electrochemical sensor for determining a presence or a concentration of an analyte in a fluid , the sensor comprising:a membrane system comprising an enzyme, wherein the enzyme reacts with the analyte;an electroactive surface comprising a working electrode, the working electrode comprising a conductive material and configured to measure a product of the reaction of the enzyme with the analyte; andan auxiliary electrode comprising a conductive material and configured to generate oxygen, wherein the auxiliary electrode is situated such that the oxygen generated diffuses to the enzyme or to the electroactive surface.2. The electrochemical sensor of claim 1 , wherein the auxiliary electrode comprises a conductive material selected from the group consisting of a conductive metal claim 1 , a conductive polymer claim 1 , and a blend of a conductive metal and a conductive polymer.3. The electrochemical sensor of claim 1 , wherein the auxiliary electrode comprises a form selected from the group consisting of a mesh claim 1 , a grid claim 1 , and a plurality of spaced wires.4. The electrochemical ...

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Номер записи: 4
20-09-2012 дата публикации

INTEGRATED DELIVERY DEVICE FOR CONTINUOUS GLUCOSE SENSOR

Номер: US20120238852A1
Автор: Brauker James H., Kamath Apurv U., Markovic Dubravka, Mensinger Michael Robert, Neale Paul V., Saint Sean T., Simpson Peter C., Tapsak Mark A.
Принадлежит: DexCom, Inc.

Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction. 1. An integrated diabetes management system for selectively switching between fully-automated and semi-automated modes , the system comprising:a glucose sensor, wherein the glucose sensor is configured to substantially continuously measure glucose concentration in a host for a period exceeding one hour, and is configured to output a data stream, including one or more sensor data points; anda processor module operably connected to the glucose sensor, wherein the processor module is configured to receive the data stream, calculate a therapy comprising instructions for administration of a medicament, and send the instructions to a medicament delivery device, wherein the processor module is configured to operate the integrated system in a fully-automated mode unless a semi-automated mode is triggered, wherein the fully automated mode does not require user interaction to send instructions to the medicament delivery device, wherein the semi-automated mode requires user interaction before sending instructions to the ...

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Номер записи: 5
18-10-2012 дата публикации

ADVANCED ANALYTE SENSOR CALIBRATION AND ERROR DETECTION

Номер: US20120262298A1
Автор: Bohm Sebastian, Rong Daiting, Simpson Peter C.
Принадлежит: DexCom, Inc.

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors. 1. A method for determining whether an analyte sensor system is functioning properly , the method comprising:applying a stimulus signal to the analyte sensor;measuring a response to the stimulus signal;estimating a value of a sensor property based on the signal response;correlating the sensor property value with a predetermined relationship of the sensor property and a predetermined sensor sensitivity profile.initiating an error routine if the correlation does not exceed a predetermined correlation threshold.2. The method of claim 1 , wherein correlating includes performing a data association analysis.3. The method of claim 1 , wherein the error routine comprises displaying a message to a user indicating that the analyte sensor is not functioning properly.4. The method of claim 1 , wherein the sensor property is an impedance of the sensor membrane.5. A sensor system configured to implement the method of .6. The sensor system of claim 1 , wherein the sensor system comprises instructions stored in computer memory claim 1 , wherein the instructions claim 1 , when executed by one or more processors of the sensor system claim 1 ...

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Номер записи: 6
18-10-2012 дата публикации

ADVANCED ANALYTE SENSOR CALIBRATION AND ERROR DETECTION

Номер: US20120265035A1
Автор: Bohm Sebastian, Rong Daiting, Simpson Peter C.
Принадлежит: DexCom, Inc

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors. 1. A method for calibrating an analyte sensor , the method comprising:applying a time-varying signal to the analyte sensor;measuring a signal response to the applied signal;determining, using sensor electronics, a sensitivity of the analyte sensor, the determining comprising correlating at least one property of the signal response to a predetermined sensor sensitivity profile; andgenerating, using sensor electronics, estimated analyte concentration values using the determined sensitivity and sensor data generated by the analyte sensor.2. The method of claim 1 , wherein the sensitivity profile comprises varying sensitivity values over time since implantation of the sensor.3. The method of claim 1 , wherein the predetermined sensitivity profile comprises a plurality of sensitivity values.4. The method of claim 1 , wherein the predetermined sensitivity profile is based on sensor sensitivity data generated from studying sensitivity changes of analyte sensors similar to the analyte sensor.5. The method of claim 1 , further comprising applying a bias voltage to the sensor claim 1 , wherein the time-varying signal comprises a step ...

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Номер записи: 7
18-10-2012 дата публикации

ADVANCED ANALYTE SENSOR CALIBRATION AND ERROR DETECTION

Номер: US20120265036A1
Автор: Estes Michael J., Kamath Apurv Ullas, Simpson Peter C.
Принадлежит: DexCom, Inc.

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors. 1. A method for calibrating sensor data generated by a continuous analyte sensor , comprising:generating sensor data using a continuous analyte sensor;iteratively determining, with an electronic device, a sensitivity value of the continuous analyte sensor as a function of time by applying a priori information comprising sensor sensitivity information; andcalibrating the sensor data based at least in part on the determined sensitivity value.2. The method of claim 1 , wherein calibrating the sensor data is performed iteratively throughout a substantially entire sensor session.3. The method of claim 1 , wherein iteratively determining a sensitivity value is performed at regular intervals or performed at irregular intervals claim 1 , as determined by the a priori information.4. The method of claim 1 , wherein iteratively determining a sensitivity value is performed throughout a substantially entire sensor session.5. The method of claim 1 , wherein determining a sensitivity value is performed in substantially real time.6. The method of claim 1 , wherein the a priori information is associated with at least one predetermined ...

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Номер записи: 8
18-10-2012 дата публикации

Advanced analyte sensor calibration and error detection

Номер: US20120265037A1
Автор: Daiting Rong, Peter C. Simpson, Sebastian Böhm
Принадлежит: Dexcom Inc

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

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Номер записи: 9
22-11-2012 дата публикации

Integrated delivery device for continuous glucose sensor

Номер: US20120296311A1
Автор: Apurv U. Kamath, Dubravka Markovic, James H. Brauker, Mark A. Tapsak, Michael Robert Mensinger, Paul V. Neale, Peter C. Simpson, Sean T. Saint
Принадлежит: Dexcom Inc

Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.

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Номер записи: 10
13-12-2012 дата публикации

Figure and a Composition for Forming the Figure

Номер: US20120315822A1
Автор: KROSKRITY Jason, MO Yuk Ha, SIMPSON Peter, WHITLEY Sean P.
Принадлежит:

A toy figure having at least one solid, molded part with a varying thickness is disclosed. The toy figure is a collector or fashion doll that has particular characteristics or properties. The toy figure is formed using a composition of ABS and barium sulfate, which provides several desired characteristics, including at least the aesthetics, feel, weight, and paintability of the toy figure. 1. A toy figure , comprising:a body including at least one molded component, the at least one molded component being formed from a composition comprising barium sulfate and ABS.2. The toy figure of claim 1 , wherein the composition includes about 20-80 weight percent barium sulfate and about 20-80 weight percent ABS.3. The toy figure of claim 2 , wherein the composition includes about 30-70 weight percent barium sulfate and about 30-70 weight percent ABS.4. The toy figure of claim 3 , wherein the composition includes about 40-60 weight percent barium sulfate and about 40-60 weight percent ABS.5. The toy figure of claim 3 , wherein the composition includes about 35-55 weight percent barium sulfate and about 45-65 weight percent ABS.6. The toy figure of claim 1 , wherein the toy figure includes a torso claim 1 , a pair of legs claim 1 , and a pair of arms claim 1 , the at least one molded component being one of the legs.7. The toy figure of claim 6 , wherein each of the legs and the arms is molded from a composition of barium sulfate and ABS.8. The toy figure of claim 1 , wherein the composition includes a colorant.9. The toy figure of claim 1 , wherein the composition includes a flow agent.10. A toy figure included a molded portion claim 1 , the molded portion consisting essentially of:barium sulfate; andABS.11. The toy figure of claim 10 , wherein the molded portion includes about 20-80 weight percent barium sulfate and about 20-80 weight percent ABS.12. The toy figure of claim 11 , wherein the molded portion includes about 30-70 weight percent barium sulfate and about 30-70 ...

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Номер записи: 11
03-01-2013 дата публикации

Method and Apparatus for Syngas Fermentation with High Co Mass Transfer Coefficient

Номер: US20130005014A1
Автор: Bell Peter Simpson, Ko Ching-Whan
Принадлежит:

A process and apparatus is provided which are effective for improving CO mass transfer. The process includes introducing syngas into a reactor vessel through a gas sparger located below a liquid level in the reactor vessel. The syngas being introduced at a flow rate effective for maintaining a pressure inside of the reactor vessel of at least about 1 psig. An agitation energy of about 0.01 to about 12 kWatts/mmedium is provided. The process is effective for providing a volumetric CO mass transfer coefficient of about 100 to about 1500 per hour. 1. A process for fermentation of syngas , the process comprising:{'sub': '2', 'introducing the syngas into a reactor vessel through a gas sparger, the gas sparger located below a liquid level in the reactor vessel, the syngas being introduced at a flow rate effective for maintaining a pressure inside of the reactor vessel of at least about 1 psig, wherein the syngas has a CO/COmolar ratio of at least about 0.75; and'}{'sup': '3', 'providing an agitation energy input to the reactor vessel of about 0.01 to about 12 kWatts/mmedium,'}wherein the process is effective for providing a volumetric CO mass transfer coefficient of about 100 to about 1500 per hour.2. The process of wherein agitation in the reactor vessel is provided by one or more of a mechanical agitator claim 1 , gas injection claim 1 , liquid injection claim 1 , and liquid recirculation (pump around).3. The process of wherein the gas sparger includes holes having a diameter of 10 mm or less.4. The process of wherein the gas sparger includes holes having a diameter of 2.5 mm or less.5. The process of wherein the syngas is introduced into the reactor vessel at a gas velocity of 25 m/sec or greater at an exit of the holes.6. The process of wherein the syngas pressure drop across the sparger is about 0.5 to about 2.5 psi.7. The process of wherein the agitation energy is about 0.9 to about 12 kWatts/m.8. The process of wherein syngas is introduced at a flow rate effective ...

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Номер записи: 12
03-01-2013 дата публикации

PROCESS FOR FERMENTATION OF SYNGAS

Номер: US20130005021A1
Автор: Bell Peter Simpson, Ko Ching-Whan
Принадлежит:

A process for fermenting syngas is provided which is effective for decreasing an amount of time needed to inoculate a main reactor. The process includes propagating a culture of acetogenic bacteria to provide an inoculum for a main reactor and fermenting syngas in the main reactor. 1. A process for fermenting syngas comprising propagating a culture of acetogenic bacteria effective for inoculating a main reactor , the propagating including ,i) inoculating a first culture of acetogenic bacteria into a pre-reactor to provide a minimum viable cell density, (a) wherein, if (the pre-reactor target cell density multiplied by the pre-reactor volume)÷(a volume of the main reactor multiplied by (a volume of the pre-reactor÷a volume of the pre-reactor which is transferred)) is greater than or equal to a minimum viable cell density, transfer a volume of the pre-reactor to the main reactor in an amount effective for providing a minimum viable cell density in the main reactor, or', '(b) if (the pre-reactor target cell density multiplied by the pre-reactor volume)÷(a volume of the main reactor multiplied by (a volume of the pre-reactor÷a volume of the pre-reactor which is transferred)) is less than a minimum viable cell density, transfer a volume of the pre-reactor to a subsequent pre-reactor in an amount effective for providing a minimum viable cell density in a subsequent pre-reactor, and, 'ii) growing the culture of acetogenic bacteria in the pre-reactor to provide a pre-reactor target cell density,'}iii) repeat step ii until a volume of pre-reactor is transferred to the main reactor.2. The process of wherein the minimum viable cell density is at least about 0.2 grams per liter.3. The process of wherein the pre-reactor target cell density is at least about 5 grams per liter.4. The process of wherein about 25% to about 75% of a volume of a pre-reactor is used to inoculate a subsequent pre-reactor or main reactor.5. The process of wherein a volume ratio of the pre-reactor volume ...

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Номер записи: 13
31-01-2013 дата публикации

HANDHOLDABLE LASER DEVICE FEATURING SENSOR FOR EYE SAFE ACTIVATION

Номер: US20130030422A1
Автор: Krishnan Srinivasan, PARENT Thomas Gerard, SIMPSON Peter, Yan Xiaomin
Принадлежит: CONOPCO, INC., D/B/A UNILEVER

A laser device for treating skin is provided which includes a handholdable housing; a laser member arranged within the housing emitting an output beam; a capacitance sensor arranged at the first end of the housing which includes a plate surrounding and defining a window through which the output beam exits, the plate having at least three segments with each flexibly movable in and out of a common plane, each of the segments being connected to an electrode, the electrodes operating to determine dielectric constants of a skin surface; a signal and control storage device communicating with the sensor comparing input signals of measured dielectric constant values to a stored standard dielectric constant value, and wherein emission of the output beam is activated to fire only when all of the at least three segments align in a plane and sense the stored standard dielectric constant value. 2. The device according to wherein the plate is an annular ring with the segments being three in number and each occupies one third of the annular ring claim 1 , a non-electrical conductive gap separating each of the segments.3. The device according to wherein the signal and control storage device is a printed circuitboard.4. The device according to wherein the output beam emits electromagnetic radiation of wavelength ranging from 1420 to 1470 nm.5. The device according to wherein the output beam has a fluence range from 0.5 to 5 joules/cm.6. The device according to wherein the output beam has a fluence range from 1 to 3 joules/cm. 1. Field of the InventionThe invention concerns a cordless handholdable laser device featuring a sensor controlling beam activation to insure an eye safe operation.2. The Related ArtDevices based on light amplification by stimulated emission of radiation (laser) have revolutionized many areas of dermatological medicine and of cosmetics. Amongst skin conditions responsive to treatment are acne scars, rosacea, hyperpigmentation, unwanted hair and dermal ...

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Номер записи: 14
07-02-2013 дата публикации

SYSTEMS AND METHODS FOR DETECTING GLUCOSE LEVEL DATA PATTERNS

Номер: US20130035575A1
Автор: Boock Robert J., Bowman Leif N., Hampapuram Hari, Kamath Apurv Ullas, Mayou Phil, Mensinger Michael Robert, Price David, Reihman Eli, Simpson Peter C., Snisarenko Kostyantyn, Weindel Keri
Принадлежит: DexCom, Inc.

Systems and methods for detecting and reporting patterns in analyte concentration data are provided. According to some implementations, an implantable device for continuous measurement of an analyte concentration is disclosed. The implantable device includes a sensor configured to generate a signal indicative of a concentration of an analyte in a host, a memory configured to store data corresponding at least one of the generated signal and user information, a processor configured to receive data from at least one of the memory and the sensor, wherein the processor is configured to generate pattern data based on the received information, and an output module configured to output the generated pattern data. The pattern data can be based on detecting frequency and severity of analyte data in clinically risky ranges. 1. An analyte concentration monitoring system , comprising:a display screen;one or more processors;an input module configured to receive sensor data from an analyte sensor configured to generate sensor data points indicative of a measured an analyte concentration;memory; and instructions to apply a weighted value to each sensor data point falling within a timeframe of sensor data, the weighted value depending upon a concentration value of the sensor data;', 'instructions to aggregate the weighted sensor data according to time of day; and', 'instructions to display the aggregated, weighted sensor data on a chart., 'one or more programs, wherein the one or more programs are stored in the memory and are configured to be executed by the one or more processors, the one or more programs including2. The system of claim 1 , wherein aggregating the sensor data according to time of day includes aggregating each sensor data point that falls within the same five minute interval of a day.3. The system of claim 1 , further comprising instructions to highlight significant time ranges of the displayed sensor data claim 1 , wherein significant time ranges of displayed data ...

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Номер записи: 15
07-02-2013 дата публикации

SYSTEMS AND METHODS FOR DETECTING GLUCOSE LEVEL DATA PATTERNS

Номер: US20130035865A1
Автор: Boock Robert J., Bowman Leif N., Hampapuram Hari, Kamath Apurv Ullas, Mayou Phil, Mensinger Michael Robert, Price David, Reihman Eli, Simpson Peter C., Snisarenko Kostyantyn, Weindel Keri
Принадлежит: DexCom, Inc.

Systems and methods for detecting and reporting patterns in analyte concentration data are provided. According to some implementations, an implantable device for continuous measurement of an analyte concentration is disclosed. The implantable device includes a sensor configured to generate a signal indicative of a concentration of an analyte in a host, a memory configured to store data corresponding at least one of the generated signal and user information, a processor configured to receive data from at least one of the memory and the sensor, wherein the processor is configured to generate pattern data based on the received information, and an output module configured to output the generated pattern data. The pattern data can be based on detecting frequency and severity of analyte data in clinically risky ranges. 1. An analyte monitoring system configured to measure an analyte concentration of a host , the system comprising:a sensor configured to generate sensor data indicative of a concentration of an analyte in a host over time;a memory configured to store the sensor data;a processor configured to receive the sensor data from at least one of the memory and detecting a pattern in the data, the detecting comprising identifying a plurality of events based on the sensor data, associating at least some of the plurality of events based on a criterion to from a set of events, and qualifying the set of events as the detected pattern; andan output module configured to output information representative of the detected pattern.2. The system of claim 1 , wherein the criterion is a timeframe.3. The system of claim 1 , wherein qualifying the set of events as a pattern comprises determining a priority score associated with the set.4. The system of claim 3 , wherein the set qualifies as a pattern if the priority score exceeds a threshold.5. The system of claim 3 , wherein the associating includes forming a plurality of sets claim 3 , and wherein the set qualifies as a pattern if ...

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Номер записи: 16
07-02-2013 дата публикации

SYSTEMS AND METHODS FOR DETECTING GLUCOSE LEVEL DATA PATTERNS

Номер: US20130035871A1
Автор: Boock Robert J., Bowman Leif N., Hampapuram Hari, Kamath Apurv Ullas, Mayou Phil, Mensinger Michael Robert, Price David, Reihman Eli, Simpson Peter C., Snisarenko Kostyantyn, Weindel Keri
Принадлежит: DexCom, Inc.

Systems and methods for detecting and reporting patterns in analyte concentration data are provided. According to some implementations, an implantable device for continuous measurement of an analyte concentration is disclosed. The implantable device includes a sensor configured to generate a signal indicative of a concentration of an analyte in a host, a memory configured to store data corresponding at least one of the generated signal and user information, a processor configured to receive data from at least one of the memory and the sensor, wherein the processor is configured to generate pattern data based on the received information, and an output module configured to output the generated pattern data. The pattern data can be based on detecting frequency and severity of analyte data in clinically risky ranges. 1. A method for alerting a user based on measurements of an analyte concentration , the method comprising:receiving data from at least one input, the data including measurements of an analyte concentration and time of day information;analyzing the received data;detecting a hypoglycemic event based on the data exceeding at least one predetermined threshold; anddisplaying a trend graph of glucose measurements over time on a user interface, wherein the trend graph includes an indication of a hypoglycemic reoccurrence risk associated with a predetermined amount of time following the detected hypoglycemic event.2. The method of claim 1 , wherein detecting the hypoglycemia event comprises determining an average distance and a time a segment of time the measured analyte concentration is below a predetermined analyte concentration level.31. The method of claim 1 , wherein the method of claim C is performed only when a user-selectable setting is turned on.4. The method of claim 1 , wherein the predetermined amount of time is 48 hours.5. The method of claim 1 , further comprising triggering an audible or visual alert using the user interface responsive to detecting ...

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Номер записи: 17
16-05-2013 дата публикации

ANALYTE SENSOR

Номер: US20130123596A1
Автор: Brister Mark, Kamath Apurv Ullas, Leach Jacob S., LI Ying, Rong Daiting, SAINT Sean, Simpson Peter C.
Принадлежит: DexCom, Inc.

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system. 119-. (canceled)20. A method for processing continuous analyte sensor data , the method comprising:placing a continuous analyte sensor in fluid communication with a circulatory system of a host, wherein a sensor system comprises the sensor and sensor electronics, wherein the sensor is configured to generate a signal associated with an in vivo analyte concentration when the sensor is implanted in the host,exposing the sensor to a sample from the host's circulatory system;providing a fail-safe module comprising a processor for executing computer program code stored in memory to cause the processor to:perform a steady state analysis and a transient analysis of the signal;evaluate a relationship between the steady state analysis and the transient analysis; anddetect a malfunction of the system.21. The method of claim 20 , further comprising generating a signal associated with glucose.22. The method of claim 20 , wherein the detecting step further comprises detecting an electrical malfunction.23. The method of claim 20 , wherein the detecting step further comprises detecting a fluidics malfunction.24. The method of claim 20 , wherein the placing step further comprises inserting a vascular access device into the host's circulatory system.25. The method of claim 24 , wherein the placing step further comprises fluidly coupling the sensor to the vascular access device.26. The method of claim 20 , wherein the detecting step further comprises detecting a sensor malfunction.27. The method of claim 20 , wherein the detecting step further comprises performing a waveform analysis of the signal.28. The method of claim 20 , wherein the detecting step further ...

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Номер записи: 18
23-05-2013 дата публикации

ANALYTE SENSOR

Номер: US20130131469A1
Автор: Brister Mark, Leach Jacob S., Simpson Peter C.
Принадлежит: DexCom, Inc.

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system. 121-. (canceled)22. A method for detecting a fluidics malfunction of an analyte sensor system in a circulatory system of a host , the method comprising:providing an apparatus comprising an external surface, a first orifice and a second orifice, wherein at least one of the first orifice and the second orifice is configured to couple with a fluid flow device; a lumen, at least one sensor disposed within the lumen of the apparatus;contacting the at least one sensor with a plurality of samples from the circulatory system of a host; andgenerating a signal from each of the at least one sensors for the plurality of samples;monitoring a pattern of signal increases or decreases generated from each of the at least one sensor from the plurality of samples; anddetecting a fluidics malfunction.23. The method of claim 22 , further comprising processing the signals from each of the sensors.24. The method of claim 22 , wherein the generating step comprises at least one of electrochemically generating claim 22 , optically generating claim 22 , radiochemically generating claim 22 , physically generating claim 22 , chemically generating claim 22 , immunochemically generating claim 22 , and enzymatically generating a signal from each of the plurality of sensors.25. The method of claim 22 , further comprising reinfusing the withdrawn sample into the host.2621. The method of claim claim 22 , further comprising washing the sensors with an infusion fluid.2721. The method of claim claim 22 , further comprising calibrating the signal of at least one of the sensors. This application is a continuation-in-part of U.S. application Ser. No. 11/691,466 filed Mar. 26, 2007; ...

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Номер записи: 19
23-05-2013 дата публикации

ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE

Номер: US20130131478A1
Автор: Boock Robert J., Brister Mark C., Brunner Seth R., Chee Arthur, Markovic Dubravka, Nguyen Lisa, Nicholas Melissa A., Petisce James R., Pryor Jack, Rixman Monica A., Simpson Peter C., Wightlin Matthew D., Woo Kum Ming
Принадлежит: DexCom, Inc.

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 1. An electrochemical continuous glucose sensor configured for implantation in a host , the glucose sensor comprising:an electrode configured to measure a signal indicative of a glucose concentration of a host, wherein the signal comprises a glucose-related component and a non-glucose related component; anda membrane covering at least a portion of the electrode, wherein the membrane is configured to reduce passage of an interfering species therethrough, whereby the non-glucose-related component of the signal is less than about 20% of the signal over a period of at least one day;wherein the glucose sensor has a sensitivity to glucose of from about 25 pA/mg/dL to about 500 pA/mg/dL.2. The glucose sensor of claim 1 , wherein the interfering species has an oxidation potential that overlaps with an oxidation potential of a measured species indicative of the concentration of the analyte.3. The glucose sensor of claim 1 , wherein the measured species is a product of an enzymatic reaction between glucose and an enzyme and is measured by the electrode.4. The glucose sensor of claim 1 , wherein the membrane comprises a silicone-containing polymer.5. The glucose sensor of claim 4 , wherein the silicone-containing polymer is a polysiloxanes.6. The glucose sensor of claim 4 , wherein the silicone-containing polymer is a polycarbosiloxane.7. The glucose sensor of wherein the silicone-containing polymer is a copolymer comprising a silicone segment and a polyurethane segment.8. The glucose sensor of claim 1 , wherein the membrane comprises a fluorocarbon-based material.9. The glucose sensor of claim 1 , wherein the non-glucose-related component ...

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Номер записи: 20
06-06-2013 дата публикации

Clinical trial management systems and methods

Номер: US20130144644A1
Автор: Peter Buchanan Simpson
Принадлежит: Biogenerics IP Development Pty Ltd

A method of managing a clinical trial where the clinical trial involves a follow-on biological (FOB) substance, the method comprising: receiving subject data at a computer system as the subject data becomes available, the subject data indicating effects of the administration of the FOB substance in the clinical trial; storing the subject data in a database; and making coded data electronically available to an authorised independent monitor, the coded data being based on the subject data and indicating effects of the administration of the FOB substance in the clinical trial but having subject-identifying information omitted therefrom, wherein the coded data is made available once the subject data is stored in the database.

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Номер записи: 21
27-06-2013 дата публикации

Analyte Sensor

Номер: US20130165756A1
Автор: Brister Mark, Kamath Apurv U., Simpson Peter C.
Принадлежит: DexCom, Inc.

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system. 1. A method for measuring an analyte in a host , comprising:exposing a continuous analyte detection system to a sample, wherein the continuous analyte detection system comprises a continuous analyte sensor configured for contact with a sample from a circulatory system of a host in vivo and configured to generate a first signal associated with a test analyte and a second signal associated with a reference analyte, and a reference sensor configured to generate a reference signal associated with the reference analyte;receiving the first signal, the second signal, and the reference signal;calculating a calibration factor associated with a sensitivity of the continuous analyte sensor; andcalibrating the first signal, wherein calibrating comprises using the calibration factor.2. The method of claim 1 , wherein the exposing step further comprises simultaneously exposing the continuous analyte sensor and the reference sensor to the sample.3. The method of claim 1 , wherein the receiving step further comprises receiving the first signal from a first working electrode disposed under an enzymatic portion of a membrane system.4. The method of claim 3 , wherein the receiving step further comprises receiving the second signal from the first working electrode.5. The method of claim 3 , wherein the receiving step further comprises receiving the second signal from a second working electrode disposed under the membrane system.7. The method of claim 5 , wherein the receiving step further comprises receiving a non-analyte-related signal from a third working electrode disposed under a non-enzymatic portion of the membrane system.8. The method of claim 1 , wherein ...

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Номер записи: 22
29-08-2013 дата публикации

PROCESS AND APPARATUS FOR PRODUCING ETHYLENE VIA PREPARATION OF SYNGAS

Номер: US20130224808A1
Автор: Bell Peter Simpson, Parker Graeme Alexander, Turnbull Neil, Williams Vaughn Clifford
Принадлежит: Ineos Commercial Services UK Limited

A process for producing ethylene from a carbonaceous containing feedstock the process comprising the steps of a) reforming the carbonaceous containing feedstock into a first product stream comprising carbon dioxide, carbon monoxide and hydrogen; b) fermenting the first product stream with an acetogenic anaerobic bacteria to produce a second product stream comprising ethanol; c) concentrating ethanol from the second product stream into a third product stream and; d) dehydrating ethanol in the third product stream to produce ethylene. 118-. (canceled)19. A process for producing ethylene from a carbonaceous containing feedstock the process comprising the steps ofa) reforming the carbonaceous containing feedstock into a first product stream comprising carbon dioxide, carbon monoxide and hydrogen;b) fermenting the first product stream with an acetogenic anaerobic bacteria to produce a second product stream comprising ethanol;c) concentrating ethanol from the second product stream into a third product stream; andd) dehydrating ethanol in the third product stream to produce a first, ethylene enriched, carbonaceous fraction, a second, ethylene depleted, carbonaceous fraction and water andd1) recycling at least a part of the water, optionally after treatment, to step b) and/or to step a) and/or recycling at least a part of the second, ethylene depleted carbonaceous fraction as a feedstock to step a).20. A process for producing an olefin derivative the process comprisinga) reforming the carbonaceous containing feedstock into a first product stream comprising carbon dioxide, carbon monoxide and hydrogen;b) fermenting the first product stream with an acetogenic anaerobic bacteria to produce a second product stream comprising ethanol;c) concentrating ethanol from the second product stream into a third product stream;d) dehydrating ethanol in the third product stream to produce a first, ethylene enriched, carbonaceous fraction, a second, ethylene depleted, carbonaceous fraction ...

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Номер записи: 23
05-09-2013 дата публикации

DUAL ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR

Номер: US20130231542A1
Автор: Brister Mark, Pryor Jack, Simpson Peter C., Wightlin Matthew
Принадлежит: DexCom, Inc.

Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data. 1. A continuous glucose sensor configured and arranged for insertion into a host for and detecting glucose in the host , the sensor comprising:a first working electrode comprising a first resistance domain, wherein the first working electrode is configured to generate a first signal having a first noise component related to a noise-causing species;a second working electrode comprising a second resistance domain, wherein the second working electrode is configured to generate a second signal having a second noise component related to the noise-causing species; anda third resistance domain disposed continuously over the first resistance domain and the second resistance domain.2. The sensor of claim 1 , wherein the noise-causing species comprises at least one member selected from the group consisting of externally produced HO claim 1 , urea claim 1 , lactic acid claim 1 , phosphates claim 1 , citrates claim 1 , peroxides claim 1 , amino acids claim 1 , amino acid precursors claim 1 , amino acid break-down products claim 1 , nitric oxide claim 1 , NO-donors claim 1 , NO-precursors claim 1 , reactive oxygen species claim 1 , compounds having electroactive acidic claim 1 , amine or sulfhydryl groups claim 1 , acetaminophen claim 1 , ascorbic acid claim 1 , dopamine claim 1 , ephedrine claim 1 , ibuprofen claim 1 , L-dopa claim 1 , methyldopa claim 1 , salicylate claim 1 , tetracycline claim 1 , tolazamide claim 1 , tolbutamide claim 1 , and triglycerides.3. The sensor of claim 1 , wherein the noise-causing species is non-constant.4. The ...

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Номер записи: 24
19-09-2013 дата публикации

SYSTEMS AND METHODS FOR PROCESSING ANALYTE SENSOR DATA

Номер: US20130245401A1
Автор: Bohm Sebastian Sebastian, Bohnett Lucas, Estes Michael J., Garcia Arturo, Kamath Apurv Ullas, Mahalingam Aarthi, Peyser Thomas A., Rack-Gomer Anna Leigh, Simpson Peter C., Vanslyke Stephen J.
Принадлежит: DexCom, Inc.

Systems and methods for applying time-dependent algorithmic compensation functions to data output from a continuous analyte sensor. Some embodiments determine a time since sensor implantation and/or whether a newly initialized sensor has been used previously. 1. A method of processing sensor data output by a continuous analyte sensor implanted within a body , comprising:measuring a change in sensitivity or baseline of the sensor over a time interval;determining a drift compensation function to be applied to a plurality of time-spaced data points output by the sensor; andapplying the drift compensation function continuously to the data points.2. The method of claim 1 , wherein measuring the change in sensitivity or baseline of the sensor comprises comparing a measured sensitivity or baseline of the sensor to a predetermined sensitivity or baseline of the sensor.3. The method of claim 2 , wherein determining a drift compensation function to be applied is based claim 2 , at least in part claim 2 , on the predetermined sensitivity or baseline.4. The method of claim 2 , wherein a value of the predetermined sensitivity or baseline is encoded on sensor electronics.5. The method of claim 1 , further comprising comparing the measured change in sensitivity or baseline of the sensor to a priori knowledge regarding the change in sensitivity or baseline of the sensor over the time interval.6. The method of claim 1 , further comprising claim 1 , based on the measured change in sensitivity or baseline of the sensor claim 1 , determining whether the sensor has been previously used.7. The method of claim 1 , wherein measuring the change in sensitivity or baseline of the sensor occurs only after the sensor has been implanted within the body for at least a minimum duration.8. The method of claim 1 , further comprising prompting a user for a reference analyte value when the measured change in sensitivity or baseline of the sensor exceeds a criterion.9. The method of claim 1 , further ...

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Номер записи: 25
19-09-2013 дата публикации

SYSTEMS AND METHODS FOR PROCESSING ANALYTE SENSOR DATA

Номер: US20130245981A1
Автор: Bohm Sebastian, Bohnett Lucas, Estes Michael J., Garcia Arturo, Kamath Apurv Ullas, Mahalingam Aarthi, Peyser Thomas A., Rack-Gomer Anna Leigh, Simpson Peter C., Vanslyke Stephen J.
Принадлежит: DexCom, Inc.

Systems and methods for applying time-dependent algorithmic compensation functions to data output from a continuous analyte sensor. Some embodiments determine a time since sensor implantation and/or whether a newly initialized sensor has been used previously. 1. A method for processing sensor data of a continuous analyte sensor implanted within a body , comprising:initializing the sensor;applying a first set of time-dependent algorithmic functions to data associated with the sensor during a first interval based on a first elapsed time since the sensor was implanted; andapplying a second set of time-dependent algorithmic functions to the data associated with the sensor during a second interval after the first interval based on a second elapsed time since the sensor was implanted.2. The method of claim 1 , wherein initializing the sensor comprises engaging electronics associated with the sensor with a housing.3. The method of claim 2 , wherein engagement of the electronics with the receiving unit is detected and initialization commences automatically upon detection of the engagement.4. The method of claim 1 , further comprising determining whether the sensor has been previously used.5. The method of claim 4 , wherein determining whether the sensor has been previously used comprises comparing a conversion function of the sensor with a conversion function of a previously removed sensor.6. The method of claim 4 , wherein determining whether the sensor has been previously used comprises reading a raw signal of the sensor.7. The method of claim 4 , wherein determining whether the sensor has been previously used comprises comparing a sensitivity and/or baseline of the sensor with a sensitivity and/or baseline of a previously removed sensor.8. The method of claim 4 , wherein determining whether the sensor has been previously used comprises comparing a trend in a signal from the sensor with a trend in a signal from a previously removed sensor.9. The method of claim 4 , ...

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Номер записи: 26
26-09-2013 дата публикации

PROCESS AND APPARATUS FOR THE PRODUCTION OF ALCOHOLS

Номер: US20130252299A1
Автор: Bell Peter Simpson, Cooke Brian Henry, Turnbull Neil
Принадлежит: Inoeos Commercial Services UK Limited

A process for the production of C2alcohols from a methane-containing feedstock which process comprises a) optionally reacting in a pre-reformer the methane-containing feedstock in the presence of steam, where the steam plus C0to methane molar ratio is less than 5:1; b) reforming at least a portion of the methane-containing feedstock in a first reformer optionally in the presence of steam, where the steam plus C0to methane molar ratio is less than 5:1 to produce a first product stream comprising CO, Hand C0; c) optionally subjecting at least a portion of the first product stream and/or a portion of the methane containing feedstock to a reforming process in a second reformer in the presence of steam and oxygen to produce a second product stream comprising CO, Hand C0d) subjecting the product streams to a bacterial fermentation process in a fermenter to produce a third product stream comprising an aqueous solution of at least one C2alcohol, nutrients and reaction intermediates and a fourth product stream comprising CO, Hand C0at least 60% of the CO being converted; e) recycling at least a portion of the fourth product stream to the methane-containing feedstock; f) recovering at least a part of the at least one C2alcohols from the third product stream to leave a fifth product stream; and g) recycling at least a part of the fifth product stream to the fermenter. 129-. (canceled)30. A process for the production of C2+ alcohols from a methane-containing feedstock which process comprises{'sub': 2', '2, 'b) reforming at least a portion of the methane-containing feedstock in a first reformer to produce a first product stream comprising CO, Hand CO;'}{'sub': 2', '2, 'c) subjecting least a portion of the first product stream and/or a portion of the methane containing feedstock to a reforming process in a second reformer in the presence of steam and oxygen to produce a second product stream comprising CO, Hand CO;'}{'sub': 2', '2, 'd) subjecting the first and second product ...

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Номер записи: 27
03-10-2013 дата публикации

TRANSCUTANEOUS ANALYTE SENSOR

Номер: US20130255570A1
Автор: Brauker James, Brister Mark, Ha Victor, NOLTING John, Petisce James R., SAINT Sean, Simpson Peter C., Woo Kum Ming
Принадлежит: DexCom, Inc.

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 1. A system for manufacturing a continuous glucose sensor , comprising:a plurality of stations; andan automated or semi-automated mechanism configured to continuously move an elongated conductive body through the plurality of stations;wherein the elongated conductive body comprises an electroactive surface, and wherein the plurality of stations are configured to serially deposit a plurality of membrane layers to form a membrane configured to control a flux of glucose to the electroactive surface.2. The system of claim 1 , wherein the plurality of stations comprise a station for cutting the elongated conductive body to form a plurality of continuous glucose sensors.3. The system of claim 1 , wherein the plurality of stations comprises a station for curing the membrane.4. The system of claim 1 , wherein the plurality of stations comprises a station for depositing a coating material to form a layer comprising an enzyme.5. The system of claim 1 , wherein the plurality of stations comprises a station for depositing a coating material to form a layer configured to block or reduce passage of one or more interferents.6. The system of claim 1 , wherein the plurality of stations comprises a station for depositing a coating material to form a layer configured to control a flux of glucose.7. The system for claim 1 , wherein the elongated conductive body comprises at least one material selected from the group consisting of: platinum claim 1 , platinum-iridium claim 1 , palladium claim 1 , graphite claim 1 , gold claim 1 , carbon claim 1 , conductive polymer claim 1 , and alloys or combinations thereof.8. The system of claim 1 , wherein the elongated conductive body comprises a plated wire.9. The system of claim 1 , wherein the automated or semi-automated ...

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Номер записи: 28
03-10-2013 дата публикации

PARTICLE-CONTAINING MEMBRANE AND PARTICULATE ELECTRODE FOR ANALYTE SENSORS

Номер: US20130261417A1
Автор: Boock Robert J., Simpson Peter C., Wightlin Matthew D.
Принадлежит:

Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 1. A system for continuous in vivo measurement of an analyte in a host , the system comprising:a continuous analyte sensor configured for implantation in a host and configured to generate a signal indicative of an analyte concentration; anda layer disposed over at least a portion of the sensor, wherein the layer comprises a particle-containing domain comprising a metal, wherein the particle-containing domain is configured to react with at least one interfering species.2. The system of claim 1 , wherein the particle-containing domain is more distal to the sensor than other domains of the layer.3. The system of claim 1 , wherein the particle-containing domain comprises at least one material selected from the group consisting of platinum claim 1 , platinum-iridium claim 1 , iridium claim 1 , palladium claim 1 , graphite claim 1 , gold claim 1 , silver claim 1 , silver chloride claim 1 , carbon claim 1 , and conductive polymers.4. The system of claim 1 , wherein the metal comprises sputtered metal.5. The system of claim 4 , wherein the sputtered metal is platinum.6. The system of claim 1 , wherein the particle-containing domain comprises a conductive particles concentration that is sufficient for the particle-containing domain to function as a conductive film.7. The system of claim 1 , wherein the particle-containing domain is configured to reduce flux therethrough of hydrogen peroxide.8. The system of claim 1 , wherein the particle-containing domain is non-powered.9. The system of claim 1 , wherein the particle-containing domain is powered.10. The system of claim 9 , wherein the sensor electronics are configured to apply a potential to the particle-containing domain.11. The system ...

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Номер записи: 29
10-10-2013 дата публикации

TRANSCUTANEOUS ANALYTE SENSORS, APPLICATORS THEREFOR, AND ASSOCIATED METHODS

Номер: US20130267811A1
Автор: Bohm Sebastian, DeRenzy David, Halac Jason, Kline Daniel S., Lieu Phong, Livingston Adam J., Masterson Steve, Neale Paul V., Pryor Jack, Simpson Peter C., Ubach Antonio Joao
Принадлежит: DexCom, Inc.

The present embodiments relate generally to systems and methods for measuring an analyte in a host. More particularly, the present embodiments provide sensor applicators and methods of use with pushbutton activation that implant the sensor, withdraw the insertion needle, engage the transmitter with the housing, and disengage the applicator from the housing, all in one smooth motion. Some embodiments contemplate engagement of the transmitter with the housing after release of the applicator. 1. A device for applying an on-skin sensor assembly to skin of a host , the device comprising:a base configured to secure a housing, wherein the housing is configured to receive an electronics unit, wherein the electronics unit is configured to generate analyte information based on a signal from a sensor;a sensor insertion mechanism configured to insert the sensor into the host; anda trigger configured, in response to being activated, to cause the sensor insertion mechanism to insert the sensor into the host, to secure the electronics unit to the housing such that the sensor electrically contacts the electronics unit, and to cause the housing to detach from the base.2. The device of claim 1 , wherein the electronics unit is configured claim 1 , in response to the trigger being activated and/or the electrical connection of the sensor to the electronics unit claim 1 , to generate analyte information.3. The device of claim 1 , wherein the housing is configured such that the electronics unit cannot be removed from the housing while the housing is adhered to the skin of the host.4. The device of claim 1 , wherein the base is configured to draw the electronics unit into the housing.5. The device of claim 1 , further comprising a standoff configured to limit an extent to which the electronics unit is inserted into the housing prior to sensor insertion.6. The device of claim 5 , wherein the trigger is further configured claim 5 , in response to being activated claim 5 , to release the ...

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Номер записи: 30
10-10-2013 дата публикации

TRANSCUTANEOUS ANALYTE SENSORS, APPLICATORS THEREFOR, AND ASSOCIATED METHODS

Номер: US20130267812A1
Автор: Bohm Sebastian, DeRenzy David, Halac Jason, Kline Daniel S., Lieu Phong, Livingston Adam J., Masterson Steve, Neale Paul V., Pryor Jack, Simpson Peter C., Ubach Antonio Joao
Принадлежит: DexCom, Inc.

The present embodiments relate generally to systems and methods for measuring an analyte in a host. More particularly, the present embodiments provide sensor applicators and methods of use with pushbutton activation that implant the sensor, withdraw the insertion needle, engage the transmitter with the housing, and disengage the applicator from the housing, all in one smooth motion. Some embodiments contemplate engagement of the transmitter with the housing after release of the applicator. 1. A device for applying an on-skin sensor assembly to skin of a host , the device comprising:a base configured to secure a housing; andan electronics unit including at least one electrical contact, wherein the housing is configured to receive the electronics unit, wherein the electronics unit is configured to generate analyte information based on a signal from a sensor;wherein the base includes a mechanism to apply a seating force to the electronics unit in a direction of insertion of the electronics unit into the housing upon partial seating of the electronics unit within the housing.2. The device of claim 1 , wherein the seating force is about 0.25-3 lbs.3. The device of claim 1 , wherein upon activation of the device claim 1 , a sealing force is applied to the sensor that is about 2-3 times the magnitude of the seating force.4. The device of claim 1 , wherein the mechanism includes a pair of spring arms claim 1 , wherein the spring arms are pre-loaded with stored energy claim 1 , and wherein the device is configured such that partially seating the electronics unit within the housing releases the stored energy.5. The device of claim 1 , wherein the mechanism includes a pair of spring arms claim 1 , and wherein the spring arms are pre-loaded with stored energy claim 1 , and wherein the device is configured such that activating the device releases the stored energy.6. The device of claim 1 , wherein the device is configured such that upon activation of the device the force moves ...

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Номер записи: 31
10-10-2013 дата публикации

TRANSCUTANEOUS ANALYTE SENSORS, APPLICATORS THEREFOR, AND ASSOCIATED METHODS

Номер: US20130267813A1
Автор: Bohm Sebastian, DeRenzy David, Halac Jason, Kline Daniel S., Lieu Phong, Livingston Adam J., Masterson Steve, Neale Paul V., Pryor Jack, Simpson Peter C., Ubach Antonio Joao
Принадлежит: DexCom, Inc.

The present embodiments relate generally to systems and methods for measuring an analyte in a host. More particularly, the present embodiments provide sensor applicators and methods of use with pushbutton activation that implant the sensor, withdraw the insertion needle, engage the transmitter with the housing, and disengage the applicator from the housing, all in one smooth motion. Some embodiments contemplate engagement of the transmitter with the housing after release of the applicator. 1. A method of applying an on-skin sensor assembly to a host , wherein the on-skin sensor assembly comprises a housing secured to the applicator , wherein the housing is configured to receive an electronics unit , comprising:attaching an applicator to a skin of a host, the applicator comprising a sensor insertion mechanism, a trigger, and a base;inserting the electronics unit into the housing, wherein the electronics unit is configured to generate analyte information based on a signal from a sensor;activating the trigger, thereby causing the sensor insertion mechanism to insert a sensor into the host, to secure the electronics unit to the housing such that the sensor electrically contacts the electronics unit, and to cause the housing to detach from the base; andremoving the applicator from the skin of the host, whereby an on-skin sensor assembly comprising the housing, the electronics unit, and the inserted sensor remains on the skin of the host.2. The method of claim 1 , wherein attaching the applicator to the skin of the host occurs before the electronics unit is inserted into the housing.3. The method of claim 1 , wherein attaching the applicator to the skin of the host occurs after the electronics unit is inserted into the housing.4. The method of claim 1 , further comprising claim 1 , before applying the applicator claim 1 , removing a door from the applicator covering a port configured for receiving the electronics unit when the electronics unit is inserted into the housing ...

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Номер записи: 32
02-01-2014 дата публикации

ELECTRODE SYSTEMS FOR ELECTROCHEMICAL SENSORS

Номер: US20140001042A1
Автор: Brauker James H., Carr-Brendel Victoria E., Petisce James R., Simpson Peter C.
Принадлежит: DexCom, Inc.

The present invention relates generally to systems and methods for improved electrochemical measurement of analytes. The preferred embodiments employ electrode systems including an analyte-measuring electrode for measuring the analyte or the product of an enzyme reaction with the analyte and an auxiliary electrode configured to generate oxygen and/or reduce electrochemical interferants. Oxygen generation by the auxiliary electrode advantageously improves oxygen availability to the enzyme and/or counter electrode; thereby enabling the electrochemical sensors of the preferred embodiments to function even during ischemic conditions. Interferant modification by the auxiliary electrode advantageously renders them substantially non-reactive at the analyte-measuring electrode, thereby reducing or eliminating inaccuracies in the analyte signal due to electrochemical interferants. 1. An electrochemical sensor for determining a presence or a concentration of an analyte in a fluid , the sensor comprising:a membrane system comprising an enzyme, wherein the enzyme reacts with the analyte;an electroactive surface comprising a working electrode, the working electrode comprising a conductive material and configured to measure a product of the reaction of the enzyme with the analyte; andan auxiliary electrode comprising a conductive material and configured to modify an electrochemical interferent such that the electrochemical interferent is rendered substantially electrochemically non-reactive at the working electrode.2. The electrochemical sensor of claim 1 , wherein the auxiliary electrode comprises a conductive material selected from the group consisting of a conductive metal claim 1 , a conductive polymer claim 1 , and a blend of a conductive metal and a conductive polymer.3. The electrochemical sensor of claim 1 , wherein the auxiliary electrode comprises a form selected from the group consisting of a mesh claim 1 , a grid claim 1 , and a plurality of spaced wires.4. The ...

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Номер записи: 33
02-01-2014 дата публикации

USE OF SENSOR REDUNDANCY TO DETECT SENSOR FAILURES

Номер: US20140005505A1
Автор: Bhavaraju Naresh C., Bowman Leif N., Kamath Apurv Ullas, Mahalingam Aarthi, Peyser Thomas A., Pryor Jack, Simpson Peter C.
Принадлежит: DexCom, Inc.

Devices, systems, and methods for providing more accurate and reliable sensor data and for detecting sensor failures. Two or more electrodes can be used to generate data, and the data can be subsequently compared by a processing module. Alternatively, one sensor can be used, and the data processed by two parallel algorithms to provide redundancy. Sensor performance, including sensor failures, can be identified. The user or system can then respond appropriately to the information related to sensor performance or failure. 1. A method for detecting a sensor failure in a continuous analyte monitoring system implanted in a host , the method comprising:receiving first sensor data from a first electrode implanted in the host, wherein the first sensor data are indicative of a property corresponding to the first electrode;receiving second sensor data from a second electrode implanted in the host, wherein the second sensor data are indicative of the property corresponding to the second electrode, the first electrode and the second electrode having substantially same characteristics;comparing, using a processor module, the property corresponding to the first electrode with the property corresponding to the second electrode; andidentifying a failure in at least one of the first electrode or the second electrode when a property magnitude of the first electrode is different from a property magnitude of the second electrode by a predetermined value.2. The method of claim 1 , wherein the property is sensor sensitivity to an analyte.3. The method of claim 1 , wherein the property is baseline.4. The method of claim 1 , wherein the first electrode is located substantially adjacent to the second electrode.5. The method of claim 1 , wherein the first electrode and the second electrode are separated by a distance of less than about 1 mm at a closest proximity.6. The method of claim 1 , wherein the first electrode and the second electrode are separated by a distance of less than about 0.5 ...

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Номер записи: 34
02-01-2014 дата публикации

Devices, systems, and methods to compensate for effects of temperature on implantable sensors

Номер: US20140005508A1
Автор: Jack Pryor, Jennifer Blackwell, Matthew D. Wightlin, Michael J. Estes, Peter C. Simpson, Robert J. Boock, Sebastian Böhm
Принадлежит: Dexcom Inc

Systems and methods for compensating for effects of temperature on implantable sensors are provided. In some embodiments, systems and methods are provided for measuring a temperature to determine a change in temperature in a sensor environment. In certain embodiments, a temperature compensation factor is determined based on a change in temperature of the sensor environment. The temperature compensation factor can be used in processing raw data of an analyte signal to report a more accurate analyte concentration.

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Номер записи: 35
02-01-2014 дата публикации

IMPLANTABLE SENSOR DEVICES, SYSTEMS, AND METHODS

Номер: US20140005509A1
Автор: Bhavaraju Naresh C., Bohm Sebastian, Boock Robert J., Rong Daiting, Simpson Peter C.
Принадлежит: DexCom, Inc.

Disclosed herein are devices, systems, and methods for a continuous analyte sensor, such as a continuous glucose sensor. In certain embodiments disclosed herein, various in vivo properties of the sensor's surroundings can be measured. In some embodiments, the measured properties can be used to identify a physiological response or condition in the body. This information can then be used by a patient, doctor, or system to respond appropriately to the identified condition. 1. A method for processing data from a continuous glucose sensor , the method comprising:receiving sensor data generated by a continuous glucose sensor, wherein the sensor data is indicative of a concentration of glucose in a host;identifying, using a processor module, a post-implantation loss of sensitivity of the continuous glucose sensor; andprocessing the sensor data, using the processor module, responsive to the identification of the loss of sensitivity.2. The method of claim 1 , wherein the sensor data comprises data indicative of a signal response to at least one event selected from the group consisting of a signal response to cessation of blood flow to a site surrounding sensor implantation claim 1 , a signal response to reduction of blood flow to a site surrounding sensor implantation claim 1 , and a signal response to a vasospastic event.3. The method of claim 1 , wherein identifying the post-implantation loss of sensitivity comprises determining a severity of the loss of sensitivity.4. The method of claim 3 , wherein processing the sensor data is performed based on the severity of the loss of sensitivity.5. The method of claim 1 , wherein identifying the post-implantation loss of sensitivity comprises:deactivating the continuous glucose sensor for a time period, whereby a product from a catalyzed reaction of glucose and oxygen accumulates over the time period;activating the continuous glucose sensor and measuring a signal value of the continuous glucose sensor immediately after the time ...

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Номер записи: 36
09-01-2014 дата публикации

SYSTEMS AND METHODS FOR LEVERAGING SMARTPHONE FEATURES IN CONTINUOUS GLUCOSE MONITORING

Номер: US20140012117A1
Автор: Bhavaraju Naresh C., Bowman Leif N., Carlton Alexandra Lynn, Cohen Eric, DeRenzy David, Estes Michael J., Garcia Arturo, Gauba Indrawati, Hall Ashley, Hall Thomas, Hampapuram Hari, Kazalbash Murrad, Mahalingam Aarthi, Mensinger Michael Robert, Pryor Jack, Rack-Gomer Anna Leigh, Reihman Eli, San Vicente Kenneth, Simpson Peter C., Steele Alexander, Valdes Jorge
Принадлежит: DexCom, Inc.

The present embodiments harness a wide variety of capabilities of modern smartphones, and combine these capabilities with information from a continuous glucose monitor to provide diabetics and related people with more information than the continuous glucose monitor can provide by itself. The increased information provides the diabetic with an increased likelihood of good diabetes management for better health. 1. A machine-executed method of continuous glucose monitoring for a host to facilitate management of the host's blood glucose level , the method comprising:displaying a blood glucose trend graph on a display of an electronic device;receiving an input of at least one location on the trend graph;processing the input by determining a value of the host's glucose concentration at the at least one location; andproducing an output of the value on the display.2. The method of claim 1 , wherein the input is locations of two points on the trend graph where the electronic device has sensed a user has placed his or her fingers.3. The method of claim 2 , wherein the processing comprises determining values of glucose concentration at the two points.4. The method of claim 3 , wherein the output is a value of a difference between glucose concentration values at the two points.5. The method of claim 3 , wherein the output is a value of a rate of change of glucose concentration between the two points.6. The method of claim 1 , wherein the glucose concentration trend graph comprises a macro trend graph that displays the user's glucose concentration data for a given length of time claim 1 , and a micro trend graph that displays the user's glucose concentration data for a segment of the time shown on the macro trend graph.7. The method of claim 6 , wherein a movable bar on the macro trend graph highlights the segment of the time on the macro trend graph that is displayed on the micro trend graph.8. The method of claim 7 , wherein the bar is movable to select any desired window of ...

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Номер записи: 37
09-01-2014 дата публикации

SYSTEMS AND METHODS FOR LEVERAGING SMARTPHONE FEATURES IN CONTINUOUS GLUCOSE MONITORING

Номер: US20140012118A1
Автор: Bhavaraju Naresh C., Bowman Leif N., Carlton Alexandra Lynn, Cohen Eric, DeRenzy David, Estes Michael J., Garcia Arturo, Gauba Indrawati, Hall Ashley, Hall Thomas, Hampapuram Hari, Kazalbash Murrad, Mahalingam Aarthi, Mensinger Michael Robert, Pryor Jack, Rack-Gomer Anna Leigh, Reihman Eli, San Vicente Kenneth, Simpson Peter C., Steele Alexander, Valdes Jorge
Принадлежит: DexCom, Inc.

The present embodiments harness a wide variety of capabilities of modern smartphones, and combine these capabilities with information from a continuous glucose monitor to provide diabetics and related people with more information than the continuous glucose monitor can provide by itself. The increased information provides the diabetic with an increased likelihood of good diabetes management for better health. 1. A machine-executed method of continuous analyte monitoring for a host to facilitate management of the host's analyte concentration level , the method comprising:transmitting, using a computing device, an identification of a version of an operating system of the computing device and/or a continuous analyte monitoring (CAM) software application installed on the computing device to a remote server, the CAM software application comprising instructions, when executed by a processor of the computing device, that cause the computing device to process and display analyte concentration information;receiving a response from the remote server responsive indicative of a compatibility check of the version of the operating system with the version of the CAM software application; andproducing an output to responsive to the response.2. The method of claim 1 , wherein the output comprises continuing operating the CAM module.3. The method of claim 1 , wherein the output comprises disabling one or more features of the CAM module.4. The method of claim 1 , wherein the output comprises preventing operation of the CAM module.5. The method of claim 1 , wherein the output comprises displaying a message to a user of the electronic device indicative of the compatibility check.6. The method of claim 5 , wherein the message instructs the user to change at least one of the operating system and the CAM module to a different version.7. The method of claim 1 , wherein the CAM module is a software application stored on the electronic device.8. The method of claim 1 , wherein the ...

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Номер записи: 38
09-01-2014 дата публикации

SYSTEMS AND METHODS FOR LEVERAGING SMARTPHONE FEATURES IN CONTINUOUS GLUCOSE MONITORING

Номер: US20140012510A1
Автор: Bhavaraju Naresh C., Bowman Leif N., Carlton Alexandra Lynn, Cohen Eric, DeRenzy David, Estes Michael J., Garcia Arturo, Gauba Indrawati, Hall Ashley, Hall Thomas, Hampapuram Hari, Kazalbash Murrad, Mahalingam Aarthi, Mensinger Michael Robert, Pryor Jack, Rack-Gomer Anna Leigh, Reihman Eli, San Vicente Kenneth, Simpson Peter C., Steele Alexander, Valdes Jorge
Принадлежит: DexCom, Inc

The present embodiments harness a wide variety of capabilities of modern smartphones, and combine these capabilities with information from a continuous glucose monitor to provide diabetics and related people with more information than the continuous glucose monitor can provide by itself. The increased information provides the diabetic with an increased likelihood of good diabetes management for better health. 1. A machine-executed method of continuous analyte monitoring for a host to facilitate management of the host's blood glucose level , the method comprising:receiving a first input from a timekeeping/scheduling module executed by an electronic device, the first input including information about an upcoming event;receiving a second input from a continuous analyte monitoring (CAM) device including analyte concentration data of the host;processing the first and second inputs by analyzing an event or an operational mode associated with either of the timekeeping/scheduling module or the CAM device; andproducing an output by synchronizing the event or the operational mode of at least one of the timekeeping/scheduling module and the CAM device with the other of the timekeeping/scheduling module and the CAM device.2. The method of claim 1 , wherein the output is to the timekeeping/scheduling module to schedule an event.3. The method of claim 1 , wherein the event is to eat claim 1 , to obtain a reference glucose value claim 1 , or to inject insulin.4. The method of claim 1 , wherein the wherein the output is sent to a user claim 1 , a caretaker claim 1 , a parent claim 1 , a guardian claim 1 , or a healthcare professional.5. The method of claim 1 , wherein the output is a recommendation provided via screen prompt claim 1 , text message claim 1 , e-mail message claim 1 , or a post to a social network.6. The method of claim 1 , wherein the output is a change in the operating mode of the electronic device.7. The method of claim 6 , wherein the operating mode is a vibrate ...

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Номер записи: 39
09-01-2014 дата публикации

SYSTEMS AND METHODS FOR LEVERAGING SMARTPHONE FEATURES IN CONTINUOUS GLUCOSE MONITORING

Номер: US20140012511A1
Автор: Bhavaraju Naresh C., Bowman Leif N., Carlton Alexandra Lynn, Cohen Eric, DeRenzy David, Estes Michael J., Garcia Arturo, Gauba Indrawati, Hall Ashley, Hall Thomas, Hampapuram Hari, Kazalbash Murrad, Mahalingam Aarthi, Mensinger Michael Robert, Pryor Jack, Rack-Gomer Anna Leigh, Reihman Eli, San Vicente Kenneth, Simpson Peter C., Steele Alexander, Valdes Jorge
Принадлежит:

The present embodiments harness a wide variety of capabilities of modern smartphones, and combine these capabilities with information from a continuous glucose monitor to provide diabetics and related people with more information than the continuous glucose monitor can provide by itself. The increased information provides the diabetic with an increased likelihood of good diabetes management for better health. 1. A machine-executed method of continuous analyte monitoring for a host to facilitate management of the host's blood glucose level , the method comprising:receiving a first input from a continuous analyte monitor (CAM) device including analyte concentration data of the host;receiving or determining an expected maximum value and an expected minimum reference value;receiving a first reference value from a reference analyte monitor;processing the first reference value by comparing it to the expected maximum value and the expected minimum value; andproducing an output of an alert to obtain a second reference value if the first reference value does not meet the range defined by the expected maximum value and the expected minimum value.2. The method of , wherein the method of is performed by a hand-held computing device in wireless communication with the CAM , and wherein the CAM comprises a continuous analyte sensor coupled to CAM electronics , the CAM electronics configured to calibrate the continuous analyte sensor output.3. The method of claim 2 , wherein the CAM electronics determines the expected maximum reference value and the expected minimum reference value and transmits each of the expected maximum reference value claim 2 , the expected minimum reference value and the calibrated continuous analyte sensor output to the hand-held computing device.4. The method of claim 3 , further comprising periodically and regularly establishing a wireless communication channel between the CAM electronics and the hand-held computing device claim 3 , and wherein the ...

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Номер записи: 40
06-02-2014 дата публикации

PROCESS FOR THE PRODUCTION OF ETHANOL AND BUTANOL

Номер: US20140038252A1
Автор: Bell Peter Simpson, Benstead Stephen John, Turnbull Neil
Принадлежит: INEOS BIO SA

The present invention relates to a process for the production of ethanol and butanol from biomass, and in particular to a process for the production of ethanol and butanol using two separate fermentation step subjecting the biomass feedstock to anaerobic fermentation at a pH below 6.0 and at a temperature in the range 20 to 700° C. and so as to convert the biomass to a product predominantly comprising acetic acid and butyric acid with at least a 2:1 ratio by weight of acetic acid to butyric acid, c) treating the product of stream of step (b) to separate a solution comprising the acetic acid and butyric acid by: (i) separating a solution comprising the acetic acid and butyric acid from any residual solids and (ii) separating bacteria and/or pasteurizing or sterilizing the solution from the first fermentation step, and d) in a second fermentation step fermenting the solution comprising the acetic acid and butyric acid from the step (c) to form ethanol and butanol. 121-. (canceled)22. A process for the production of ethanol and butanol using two separate fermentation steps—comprising:a) first fermentation step comprising fermenting; wherein subjecting said feedstock to anaerobic fermentation in the presence of acetogenic bacteria, further comprising a mixture of bacterial strains, at a pH below 6.0, at a temperature in the range 20 to 70 degree C., converting said feedstock to a product predominantly comprising acetic acid and butyric acid; wherein ratio of acetic acid to butyric acid is at least 2:1;b) treating said product predominantly comprising acetic acid and butyric acid of step a) to separate a solution comprising the acetic acid and butyric acid by:(i) separating residual solids; and(ii) separating bacteria; optionally pasteurizing; optionally sterilizing said solution comprising the acetic acid and butyric acid;c) second fermentation step comprising fermenting in the presence of solventogenic bacteria said solution comprising the acetic acid and butyric acid ...

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Номер записи: 41
13-02-2014 дата публикации

PROCESS FOR FERMENTATION OF SYNGAS

Номер: US20140045246A1
Автор: Bell Peter Simpson, Ko Ching-Whan
Принадлежит: INEOS BIO SA

A process for fermenting syngas is provided which is effective for decreasing an amount of time needed to inoculate a main reactor. The process includes propagating a culture of acetogenic bacteria to provide an incoulum for a main reactor and fermenting syngas in the main reactor. 110-. (canceled)11. A process for fermenting syngas comprising propagating a culture of acetogenic bacteria effective for inoculating a main fermentation reactor , the propagating including ,i) inoculating a first culture of acetogenic bacteria into a pre-reactor to provide a minimum viable cell density of at least 0.2 grams per liter, (a) wherein, if (the pre-reactor target cell density multiplied by the pre-reactor volume)÷(a volume of the main reactor multiplied by two) is greater than or equal to a minimum viable cell density, transfer a volume of the pre-reactor to the main reactor in an amount effective for providing a minimum viable cell density in the main reactor, or', '(b) if (the pre-reactor target cell density multiplied by the pre-reactor volume)÷(a volume of the main reactor multiplied by two) is less than a minimum viable cell density, adjusting the volume of the main reactor and transferring a volume of the pre-reactor to the main reactor in an amount effective for providing a minimum viable cell density in the main reactor, and increasing the volume of the main reactor while maintaining a minimum viable cell density., 'ii) growing the culture of acetogenic bacteria in the pre-reactor to provide a pre-reactor target cell density of at least 5 grams per liter,'}12. (canceled)13. (canceled)14. The process of wherein the syngas has a CO/COmolar ratio of at least about 0.75.15. The process of wherein the syngas has about 20 to about 100 mole % CO.16. The process of wherein the syngas used for propagating acetogenic bacteria is substantially CO.17. The process of wherein the first culture has a pH of 6.5 or less and an acetic acid concentration of 10 grams per liter or less. ...

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Номер записи: 42
13-02-2014 дата публикации

ANALYTE SENSOR

Номер: US20140046148A1
Автор: Book Robert J., Estes Michael J., Kamath Apurv Ullas, Simpson Peter C., Wightlin Matthew D.
Принадлежит: DexCom, Inc.

Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods. For example, a sensor system is provided having a first working electrode comprising a first sensor element and a second working electrode comprising a second sensor element , and a reference electrode for providing a reference value for measuring the working electrode potential of the sensor elements 1. A sensor system for continuous measurement of a glucose concentration in a host , the sensor system comprising:a first sensor configured to measure glucose concentrations over a first time period of in vivo implantation; anda second sensor configured to measure glucose concentrations over a second time period of in vivo implantation, wherein the first time period and the second time period are different.2. The sensor system of claim 1 , wherein the first time period corresponds to an initial period of in vivo implantation claim 1 , wherein the second time period corresponds to a second time period of in vivo implantation claim 1 , and wherein the second period begins after the initial period of in vivo implantation has begun.3. The sensor system of claim 2 , wherein the first time period and the second time period overlap partially claim ...

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Номер записи: 43
13-02-2014 дата публикации

Analyte sensor

Номер: US20140046149A1
Автор: Apurv Ullas Kamath, Matthew D. Wightlin, Michael J. Estes, Peter C. Simpson, Robert J. Boock
Принадлежит: Dexcom Inc

Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods. For example, a sensor system 180 is provided having a first working electrode 150 comprising a first sensor element 102 and a second working electrode 160 comprising a second sensor element 104 , and a reference electrode 108 for providing a reference value for measuring the working electrode potential of the sensor elements 102, 104.

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Номер записи: 44
27-03-2014 дата публикации

MULTIPLE ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR, AND RELATED METHODS

Номер: US20140088389A1
Автор: Bohm Sebastian, Boock Robert J., Simpson Peter C., Wightlin Matthew D., ZHANG Huashi
Принадлежит: DexCom, Inc.

In one embodiment, a continuous analyte sensor having more than one working electrode, and configured to reduce or eliminate crosstalk between the working electrodes. In another embodiment, a continuous analyte sensor having more than one working electrode, and configured so that a membrane system has equal thicknesses over each of the electrodes, despite having differing numbers of layers over each of the electrodes. In another embodiment, a configuration for connecting a continuous analyte sensor to sensor electronics. In another embodiment, methods for forming precise windows in an insulator material on a multi-electrode assembly. In another embodiment, a contact assembly for a continuous analyte sensor having more than one working electrode. 1. A continuous analyte sensor , comprising:a first working electrode;a second working electrode; anda membrane overlying at least a portion of the sensor, including the first and second working electrodes, the membrane being continuous, but for a first portion located between the first and second working electrodes that has properties that differ from properties of other portions of the membrane.2. The continuous analyte sensor of claim 1 , wherein at least one of the properties is permeability.3. The continuous analyte sensor of claim 2 , wherein the first portion is cross-linked.4. The continuous analyte sensor of claim 2 , wherein the other portions are cross-linked claim 2 , and the first portion is cross-linked by an amount different from the other portions.5. The continuous analyte sensor of claim 2 , wherein the first portion has a lower content of a hydrophilic species than the other portions.6. The continuous analyte sensor of claim 5 , wherein the hydrophilic species is removed by a secondary removal process claim 5 , a leaching process claim 5 , or a precipitation process involving heat claim 5 , pH claim 5 , or solvents.7. The continuous analyte sensor of claim 1 , wherein the first portion comprises a ...

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Номер записи: 45
27-03-2014 дата публикации

Analyte Sensor

Номер: US20140088391A1
Автор: Brister Mark, Leach Jacob S., Simpson Peter C., Yang Richard C.
Принадлежит: DexCom, Inc.

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system. 1. An integrated sensor system for measuring an analyte in a sample of a host and for fluid infusion into the host , comprising:an analyte sensor configured and arranged for measuring an analyte concentration in a biological sample of a circulatory system of a host;a vascular access device;tubing assembly comprising tubing; anda flow control device configured to regulate exposure of the analyte sensor to a biological sample and to a reference solution according to a flow profile, wherein the flow control device comprises a valve, and wherein the valve is configured and arranged with a gravity flow position and a controlled flow position.2. The system of claim 1 , wherein the system is configured such that the analyte sensor is flushed by the reference solution when the valve is in the gravity flow position.3. The system of claim 2 , wherein the gravity flow position comprises a first flow rate of the solution claim 2 , wherein the controlled flow position comprises a second flow rate of the solution claim 2 , and wherein a ratio of the first flow rate to the second flow rate is at least about 10:1.4. The system of claim 3 , wherein the gravity flow position has a flow rate of at least about 600 ml/hr.5. The system of claim 3 , wherein the controlled flow position has a flow rate of from about 0.5 ml/hr to about 4.0 ml/hour.6. The system of claim 1 , wherein the valve is configured and arranged to receive the tubing in a substantially linear configuration.7. The system of claim 6 , wherein the valve and the tubing assembly are configured and arranged such that the tubing is in a stretched state after installation of the tubing in the valve.8. ...

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Номер записи: 46
03-04-2014 дата публикации

RECEIVERS FOR ANALYZING AND DISPLAYING SENSOR DATA

Номер: US20140091940A1
Автор: Chico Holly, Constantine Kassandra, Hall Thomas, Hampapuram Hari, JOHNSON Eric, Mensinger Michael Robert, Reihman Eli, Simpson Peter C., Snisarenko Kostyantyn
Принадлежит: DexCom, Inc.

This disclosure provides systems, methods and apparatus for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor. The system may include a display device with at least one input device. In response to movement of or along the input device, the display device may change a glucose data output parameter and update an output of the display device using the changed output parameter. 120-. (canceled)21. The method for presenting an interactive glucose chart on a display device , comprising:displaying on a touch-sensitive display of a computing device a glucose trend chart displaying monitored glucose levels of a host over a first time range; anddisplaying on the display a navigation bar simultaneously with the glucose trend chart, the navigation bar displaying a graph of the monitored glucose levels of the host over a second time range that is greater than and encompasses the first time range, wherein predetermined user interaction with the navigation bar detected by the computing device changes the first time range of glucose data.22. The method of claim 21 , wherein the navigation bar is positioned adjacent to the glucose trend chart on the display.23. The method of claim 21 , wherein the navigation bar includes an indication of the first time range.24. The method of claim 23 , wherein the graph of the navigation bar displays the glucose data encompassed by the first time range differently than the glucose data not encompassed by the first time range.25. The method of claim 24 , wherein the glucose data encompassed by the first time range displayed on the navigational bar is shaded differently than the data not encompassed by the first time range.26. The method of claim 23 , wherein the indication of the first time range includes a selectable slider bar that can be touched and dragged by a user across the navigational bar to change the first time range.27. The method of claim 23 , further comprising increasing a ...

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Номер записи: 47
03-04-2014 дата публикации

RECEIVERS FOR ANALYZING AND DISPLAYING SENSOR DATA

Номер: US20140091941A1
Автор: Chico Holly, Constantine Kasandra, Hall Thomas, Hampapuram Hari, JOHNSON Eric, Mensinger Michael Robert, Reihman Eli, Simpson Peter C., Snisarenko Kostyantyn
Принадлежит: DexCom, Inc.

This disclosure provides systems, methods and apparatus for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor. The system may include a display device with at least one input device. In response to movement of or along the input device, the display device may change a glucose data output parameter and update an output of the display device using the changed output parameter. 120-. (canceled)21. A glucose monitoring system for monitoring a host's glucose levels , the system comprising a computing device having a touch-sensitive display , wherein the computing device is configured to:display on the touch-sensitive display a first chart and a second chart adjacent to one another, each chart having a y-axis in units of an analyte concentration and an x-axis in units of time, and each x-axis of the first and second charts extending different periods of time, wherein the x-axis of the first chart extends a first period of time and the x-axis of the second chart extends a second period of time, the first period of time being a sub-set of the second period of time, and wherein the second chart additionally comprises an indication of the first time period.22. The computing device of claim 21 , wherein the computing device is further configured to change the first time period in response to the computing device detecting a predefined user input.23. The computing device of claim 22 , wherein the predefined user input comprises a predefined user gesture on the user interface.24. The computing device of claim 23 , wherein the predefined user gesture comprises a tap on the display claim 23 , a swipe on the display claim 23 , or a selection and dragging of an icon on the display.25. The computing device of claim 21 , wherein the indication of the first time period comprises a bar extending along the y-axis of the second chart claim 21 , and wherein the bar moves along the x-axis of the second chart responsive to a user changing ...

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Номер записи: 48
03-04-2014 дата публикации

RECEIVERS FOR ANALYZING AND DISPLAYING SENSOR DATA

Номер: US20140094673A1
Автор: Chico Holly, Constantine Kassandra, Hall Thomas, Hampapuram Hari, JOHNSON Eric, Mensinger Michael Robert, Reihman Eli, Simpson Peter C., Snisarenko Kostyantyn
Принадлежит: DexCom, Inc.

This disclosure provides systems, methods and apparatus for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor. The system may include a display device with at least one input device. In response to movement of or along the input device, the display device may change a glucose data output parameter and update an output of the display device using the changed output parameter. 120-. (canceled)22. The method of claim 21 , wherein changing the time period comprises receiving user input indicative of a request to change the time period.23. The method of claim 21 , wherein the associated event is selected from the group consisting of food claim 21 , insulin claim 21 , exercise claim 21 , sleep claim 21 , and illness.24. A method for displaying glucose information to a user using a hand-held computing device claim 21 , comprising:displaying on a touch-sensitive display of a computing device a glucose chart including a trend line indicative of a glucose level of a host over a first time period;displaying one or more event indicators on the chart, each event indicator positioned on the chart to indicate when an associated event occurred in time; andadding an indicator to the chart in response to the computing device detecting a predefined user input.25. The method of claim 24 , wherein the predefined user input comprises touching a selected portion of the glucose chart.26. The method of claim 24 , wherein the associated event is selected from the group consisting of food claim 24 , insulin claim 24 , exercise claim 24 , sleep claim 24 , and illness.27. A method for displaying glucose information to a user using a hand-held computing device claim 24 , comprising:displaying on a touch-sensitive display of a computing device a glucose chart including a trend line indicative of a glucose level of a host over a first time period;displaying one or more event indicators on the chart, each event indicator positioned on the chart ...

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Номер записи: 49
06-01-2022 дата публикации

SYSTEMS AND METHODS FOR HEALTH DATA VISUALIZATION AND USER SUPPORT TOOLS FOR CONTINUOUS GLUCOSE MONITORING

Номер: US20220000432A1
Автор: Armenta Lauren Danielle, Belliveau Scott M., Blackwell Jennifer, Bowman Leif N., Cabrera, Draeger Rian, Garcia Arturo, Goldsmith Timothy Joseph, Gray John Michael, Jackson Andrea Jean, JR. Esteban, Kamath Apurv Ullas, Koehler Katherine Yerre, Kramer Paul, Mandapaka Aditya Sagar, Mensinger Michael Robert, Mikami Sumitaka, MORRIS Gary A., Nirmal Hemant Mahendra, Noble-Campbell Paul, Pupa Philip Thomas, Reihman Eli, Simpson Peter C., Smith Brian Christopher, Wiley Atiim Joseph
Принадлежит:

Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host. 1. A system comprising:a continuous analyte sensor configured to obtain glucose data of a host; a wireless transmitter configured to receive the glucose data from the continuous analyte sensor and transmit the glucose data to a processing module; andthe processing module further configured to receive insulin data of the host, the glucose data of the host, and event data of the host and to produce a graphical display on a mobile computing device,wherein the processing module further modifies the graphical display to display a visual indicating one or more relationships of the insulin data, the glucose data, the event data with each other or time, wherein the visual is scaled to not obscure the display of the insulin, glucose or event data.2. The system of claim 1 , wherein the event data includes one or more of insulin dosing claim 1 , carbohydrate intake claim 1 , or exercise.3. The system of claim 1 , wherein the insulin data includes an insulin on board value claim 1 , and the visual comprises a colored ring indicating the insulin on board and an estimated time remaining for the insulin on board.4. The system of claim 1 , wherein the visual comprises a trend graph of the glucose data and an interactive call out window associated with a region or a feature of the trend graph that is presented when a user selects the region or the feature of the trend graph on the graphical display claim 1 , wherein the presented call-out window comprises at least some of the insulin data or the event data.5. The system of claim 4 , wherein the presented call-out window is configured to display a graphical arrangement of the insulin ...

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Номер записи: 50
07-01-2021 дата публикации

Advanced analyte sensor calibration and error detection

Номер: US20210000394A1
Автор: Daiting Rong, Peter C. Simpson, Sebastian Böhm
Принадлежит: Dexcom Inc

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

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Номер записи: 51
04-01-2018 дата публикации

ANALYTE SENSORS AND METHODS OF MANUFACTURING SAME

Номер: US20180000388A1
Автор: Bohm Sebastian, Boock Robert J., Jackson Jeff, Llevares Antonio C., Mitchell Jason, Neale Paul V., Patel Kaushik, Pryor Jack, Simpson Peter C., Wightlin Matthew
Принадлежит:

Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system comprises first and second elongated bodies E, E, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer that separates the conductive layer from the elongated body, a membrane layer deposited on top of the elongated bodies E, E, and working electrodes ″ formed by removing portions of the conductive layer and the insulating layer , thereby exposing electroactive surface of the elongated bodies E, E 1. A continuous analyte sensor configured for in vivo use , the continuous analyte sensor comprising:an elongated conductive body comprising a working electrode; anda membrane covering at least a portion of the working electrode;wherein the continuous analyte sensor has a fatigue life of at least 20 cycles of flexing of from about 45° to about −45° at a bend radius of about 0.031-inches.2. The continuous analyte sensor of claim 1 , wherein the elongated conductive body comprises an elongated core claim 1 , an insulating layer covering at least a portion of the elongated core claim 1 , a conductive layer comprising a reference electrode or a counter electrode and covering at least a portion of the insulating layer claim 1 , and a membrane covering at least a portion the working electrode.3. The continuous analyte sensor of claim 2 , wherein the elongated core comprises an elongated body and a layer of conductive material covering at least a portion of the elongated body.4. The continuous analyte sensor of claim 3 , wherein the elongated body comprises at least one material selected from the group consisting of stainless steel claim 3 , titanium claim 3 , tantalum claim 3 , and a polymer.5. The continuous analyte sensor of claim 3 , wherein the ...

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Номер записи: 52
01-01-2015 дата публикации

SOLID OXIDE FUEL CELL WITH FLEXIBLE FUEL ROD SUPPORT STRUCTURE

Номер: US20150004528A1
Автор: Heinig Brendan, Palumbo Nathan, Persky Joshua, Pink William, Simpson Peter F.
Принадлежит:

A rod assembly and method for supporting rods includes opposing end plates for supporting opposing ends of a plurality of solid oxide fuel cell rods with each rod comprising a hollow gas conduit passing there through. Each rod end is supported by an annular flexure configured to provide a gas/liquid tight seal between the rod ends and the end plates. Each annular flexure includes a flexible portion surrounding the rod end such that forces imparted to either or both of the rod and the end plate act to elastically deform the annular flexure without damaging the rods. The rod assembly operates and a Solid Oxide Fuel Cell (SOFC) with operating temperatures of 500 to 1000° C. 1. A solid oxide fuel cell comprising a fuel rod assembly comprising:a fuel rod comprising an outer wall enclosing a hollow longitudinal conduit, a cylindrical tube stub extending from each end of the outer wall wherein the hollow longitudinal conduit passes completely through the outer wall and each of the tube stubs;a first end plate base wall formed with a base wall through hole positioned to receive a first tube stub there through and a flexure element associated with each base wall through hole for engaging with a first tub stub of the fuel rod;a second end plate base wall formed with a base wall through hole positioned to receive a second tube stub there through and a flexure element associated with each base wall through hole for engaging with a second tub stub of the fuel rod;wherein each flexure element comprises a flexible portion surrounding a flexure through hole wherein the flexible portion has a mechanical stiffness that is less than a mechanical stiffness of the rod and each of the end plate base walls; and,wherein an outside diameter of each tube stub is engaged with the flexure through hole with an interference fit that provides a mechanical retention force suitable for holding the fuel rod in place and maintaining a gas tight seal between the outside diameter of the tube stub and ...

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Номер записи: 53
14-01-2021 дата публикации

SYSTEMS AND METHODS FOR DISPLAY DEVICE AND SENSOR ELECTRONICS UNIT COMMUNICATION

Номер: US20210007644A1
Автор: Burnette Douglas William, Garcia Arturo, Mandapaka Aditya, McDaniel Zebediah L., Simpson Peter C., Wedekind Jeffrey R.
Принадлежит:

Methods and apparatus are provided for communication among display devices and sensor electronics unit in an analyte monitoring system. The analyte monitoring system may include a sensor that is configured to perform measurements indicative of analyte levels. The sensor may be communicatively coupled to the sensor electronics unit. The sensor electronics unit may be configured to transmit data indicative of analyte levels to the display devices using one or more communication protocols. Furthermore, the sensor electronics unit may be configured to operate in multiple modes, and switch between the modes in response to commands received from the display devices. Related systems, methods, and articles of manufacture are also described. 1a transcutaneous glucose sensor comprising an in vivo portion, wherein the transcutaneous sensor is an electrochemical sensor, wherein the transcutaneous glucose sensor comprises a membrane and at least one electrode, wherein the at least one electrode is a working electrode;a sensor electronics unit operatively connected to the transcutaneous glucose sensor, wherein the sensor electronics unit comprises circuitry associated with measuring and processing sensor data received from the transcutaneous glucose sensor; anda display device operatively connected to the sensor electronics unit, wherein the display device is configured to display a glucose value.. A transcutaneous glucose sensor system, the system comprising: Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 16/556,144, filed Aug. 29, 2019, which is a continuation of U.S. application Ser. No. 15/471,374, filed Mar. 28, 2017, now U.S. Pat. No. 10,561,349, which claims the benefit of U.S. Provisional Application No. 62/315,976, filed on Mar. 31, 2016. Each of the aforementioned applications is incorporated by ...

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Номер записи: 54
11-01-2018 дата публикации

Advanced analyte sensor calibration and error detection

Номер: US20180008174A1
Автор: Daiting Rong, Peter C. Simpson, Sebastian Böhm
Принадлежит: Dexcom Inc

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

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Номер записи: 55
11-01-2018 дата публикации

Analyte sensing biointerface

Номер: US20180008176A1
Автор: James H. Brauker, Peter C. Simpson
Принадлежит: Dexcom Inc

Disclosed herein is an analyte sensing biointerface that comprises a sensing electrode incorporated within a non-conductive matrix comprising a plurality of passageways extending through the matrix to the sensing electrode. Also disclosed herein are methods of manufacturing a sensing biointerface and methods of detecting an analyte within tissue of a host using an analyte sensing biointerface.

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Номер записи: 56
09-01-2020 дата публикации

SYSTEMS AND METHODS FOR DISPLAY DEVICE AND SENSOR ELECTRONICS UNIT COMMUNICATION

Номер: US20200008721A1
Автор: Burnette Douglas William, Garcia Arturo, Mandapaka Aditya, McDaniel Zebediah L., Simpson Peter C., Wedekind Jeffrey R.
Принадлежит:

Methods and apparatus are provided for communication among display devices and sensor electronics unit in an analyte monitoring system. The analyte monitoring system may include a sensor that is configured to perform measurements indicative of analyte levels. The sensor may be communicatively coupled to the sensor electronics unit. The sensor electronics unit may be configured to transmit data indicative of analyte levels to the display devices using one or more communication protocols. Furthermore, the sensor electronics unit may be configured to operate in multiple modes, and switch between the modes in response to commands received from the display devices. Related systems, methods, and articles of manufacture are also described. 1. A display device for communicating with a sensor electronics unit of an analyte monitoring system , the display device comprising:a display;a first communicator configured to implement a first communication protocol having a first range;a second communicator configured to implement a second communication protocol having a second range greater than the first range;a graphical user interface configured to (1) display sensor information received from the sensor electronics unit, and (2) control operation of the first communicator and the second communicator, the graphical user interface configured to receive a user selection of one or more commands that the display can issue to the sensor electronics unit using the first communication protocol;wherein the first communicator is configured to request and receive sensor information from the sensor electronics unit using the first communication protocol when the user selects a retrieve data command; andwherein the second communicator is configured to automatically receive sensor information from the sensor electronics unit using the second communication protocol.2. The display device of claim 1 , wherein the first communicator is configured to wake up the sensor electronics unit from a low ...

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Номер записи: 57
09-01-2020 дата публикации

Systems and methods for display device and sensor electronics unit communication

Номер: US20200008722A1
Автор: Aditya Mandapaka, Arturo Garcia, Douglas William Burnette, Jeffrey R. Wedekind, Peter C. Simpson, Zebediah L. McDaniel
Принадлежит: Dexcom Inc

Methods and apparatus are provided for communication among display devices and sensor electronics unit in an analyte monitoring system. The analyte monitoring system may include a sensor that is configured to perform measurements indicative of analyte levels. The sensor may be communicatively coupled to the sensor electronics unit. The sensor electronics unit may be configured to transmit data indicative of analyte levels to the display devices using one or more communication protocols. Furthermore, the sensor electronics unit may be configured to operate in multiple modes, and switch between the modes in response to commands received from the display devices. Related systems, methods, and articles of manufacture are also described.

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Номер записи: 58
21-01-2016 дата публикации

Advanced analyte sensor calibration and error detection

Номер: US20160018246A1
Автор: Daiting Rong, Peter C. Simpson, Sebastian Böhm
Принадлежит: Dexcom Inc

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

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Номер записи: 59
16-01-2020 дата публикации

System and method for educating users, including responding to patterns

Номер: US20200020247A1
Автор: Andrew Attila Pal, Apurv Ullas Kamath, David DeRenzy, David Price, Eli Reihman, Katherine Yerre Koehler, Laura J. Dunn, Mark Wu, Matthew Lawrence Johnson, Peter C. Simpson, Robert J. Boock
Принадлежит: Dexcom Inc

Provided are systems and methods using which users may learn and become familiar with the effects of various aspects of their lifestyle on their health, e.g., users may learn about how food and/or exercise affects their glucose level and other physiological parameters, as well as overall health. In some cases the user selects a program to try; in other cases, a computing environment embodying the system suggests programs to try, including on the basis of pattern recognition, i.e., by the computing environment determining how a user could improve a detected pattern in some way. In this way, users such as type II diabetics or even users who are only prediabetic or non-diabetic may learn healthy habits to benefit their health.

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Номер записи: 60
10-02-2022 дата публикации

SYSTEMS AND METHODS FOR DISPLAY DEVICE AND SENSOR ELECTRONICS UNIT COMMUNICATION

Номер: US20220039703A1
Автор: Burnette Douglas William, Garcia Arturo, Mandapaka Aditya, McDaniel Zebediah L., Simpson Peter C., Wedekind Jeffrey R.
Принадлежит:

Methods and apparatus are provided for communication among display devices and sensor electronics unit in an analyte monitoring system. The analyte monitoring system may include a sensor that is configured to perform measurements indicative of analyte levels. The sensor may be communicatively coupled to the sensor electronics unit. The sensor electronics unit may be configured to transmit data indicative of analyte levels to the display devices using one or more communication protocols. Furthermore, the sensor electronics unit may be configured to operate in multiple modes, and switch between the modes in response to commands received from the display devices. Related systems, methods, and articles of manufacture are also described. 1a transcutaneous glucose sensor comprising an in vivo portion, wherein the transcutaneous sensor is an electrochemical sensor, wherein the transcutaneous glucose sensor comprises a membrane and at least one electrode, and wherein the at least one electrode is a working electrode;a sensor electronics unit operatively connected to the transcutaneous glucose sensor, wherein the sensor electronics unit comprises circuitry associated with measuring and processing sensor data received from the transcutaneous glucose sensor; anda display device operatively connected to the sensor electronics unit, wherein the display device is configured to display a glucose value.. A transcutaneous glucose sensor system, the system comprising: Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 17/195,237, filed Mar. 8, 2021, which is a continuation of U.S. application Ser. No. 17/014,429, filed Sep. 8, 2020, now U.S. Pat. No. 10,980,450, which is a continuation of U.S. application Ser. No. 16/556,144, filed Aug. 29, 2019, now U.S. Pat. No. 10,799,157, which is a continuation of U.S. application ...

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Номер записи: 61
24-01-2019 дата публикации

TRANSCUTANEOUS ANALYTE SENSOR

Номер: US20190021596A1
Автор: Brauker James H., Brister Mark, Goode, Holmquist Arnold L., JR. Paul V., Neale Paul V., Rhodes Rathbun K., Shults Mark, Simpson Peter C., Thrower James Patrick
Принадлежит:

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 1. An analyte measuring system , comprising:a mounting unit adapted for mounting on a skin of a host;an electronics unit detachably connectable to the mounting unit, wherein the electronics unit comprises electronic circuitry encapsulated within a sensor body, and wherein the electronic circuitry is encapsulated in the sensor body by a molding process to provide a substantially seamless exterior with a portion of an electrode system exposed on the exterior of the substantially seamless body; anda sensor configured for measuring a level of an analyte, the sensor comprising an in vivo portion for insertion through the skin at an exit site of the host and an ex vivo portion connected to the mounting unit, wherein the sensor is operably connected to the electronics unit when the electronics unit is detachably connected to the mounting unit.2. The system of claim 1 , wherein the sensor body is encapsulated in a polymer material.3. The system of claim 2 , wherein the polymer material is water vapor permeable.4. The system of claim 2 , wherein the polymer material is epoxy.5. The system of claim 1 , wherein the circuitry comprises an inductor for a voltage controlled oscillator.6. The system of claim 1 , wherein the electronic circuitry further comprises a microprocessor claim 1 , RF circuitry claim 1 , an antenna and a power source encapsulated within the body.7. The system of claim 1 , wherein at least a portion of the electronic circuitry comprises a conformal coating.8. The system of claim 1 , wherein the mounting unit comprises an opening configured to receive the sensor electronics therein.9. The system of claim 1 , further comprising an elastomeric sealing member configured to form a watertight seal at the portion of an electrode system exposed ...

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Номер записи: 62
17-04-2014 дата публикации

Sensors for continuous analyte monitoring, and related methods

Номер: US20140107450A1
Автор: Jennifer Blackwell, Peter C. Simpson, Sebastian Böhm
Принадлежит: Dexcom Inc

Sensor devices including dissolvable tissue-piercing tips are provided. The sensor devices can be used in conjunction with dissolvable needles configured for inserting the sensor devices into a host. Hardening agents for strengthening membranes on sensor devices are also provided. Methods of using and fabricating sensor devices are also provided.

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Номер записи: 63
22-01-2015 дата публикации

PARTICLE-CONTAINING MEMBRANE AND PARTICULATE ELECTRODE FOR ANALYTE SENSORS

Номер: US20150025346A1
Автор: Boock Robert J., Simpson Peter C., Wightlin Matthew D.
Принадлежит:

Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 120-. (canceled)21. A system for continuous in vivo measurement of glucose in a host , the system comprising:a continuous glucose sensor configured for implantation in a host and configured to measure in vivo a signal indicative of a glucose concentration, wherein the continuous glucose sensor comprises an electrode, wherein the electrode comprises a metal oxide and a plurality of sensing elements, wherein each sensing element comprises an electroactive surface, and wherein each sensing element is configured to detect the signal related to glucose concentration;a biocompatible membrane located over at least a portion of the electrode, wherein the biocompatible membrane is configured to reduce a flux of glucose therethrough; andsensor electronics operably connected to the continuous glucose sensor, wherein the sensor electronics are configured to process the signal from the continuous glucose sensor.22. The system of claim 21 , wherein the system is configured to determine glucose concentration by averaging or integrating signals from plurality of sensing elements.23. The system of claim 21 , wherein each of the electroactive surfaces is shaped like a circle.24. The system of claim 21 , wherein each of the electroactive surfaces is shaped like a dot.25. The system of claim 21 , wherein the electroactive surfaces all have a substantially equal area.26. The system of claim 21 , wherein the electroactive surfaces are each spaced apart from at least one adjacent electroactive surface by a substantially equal distance.27. The system of claim 21 , wherein the electroactive surfaces are spaced along a substantial length of an in vivo portion of the glucose sensor.28. The system of ...

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Номер записи: 64
23-01-2020 дата публикации

Advanced analyte sensor calibration and error detection

Номер: US20200022626A1
Автор: Daiting Rong, Peter C. Simpson, Sebastian Böhm
Принадлежит: Dexcom Inc

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

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Номер записи: 65
28-01-2021 дата публикации

ANALYTE SENSOR

Номер: US20210022653A1
Автор: Boock Robert J., Brauker James H., Brister Mark C., Rixman Monica A., Shults Mark C., Simpson Peter C.
Принадлежит:

Biointerface membranes are provided which can be utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device incorporating such membranes are provided. 1. An analyte sensing device adapted for implantation into a host's tissue , comprising:a sensor configured to measure an analyte in a host, wherein the sensor comprises a biointerface configured to promote at least one function selected from the group consisting of increasing fluid bulk surrounding at least a portion of the sensor in vivo, increasing bulk fluid flow surrounding at least a portion of the sensor in vivo, and increasing diffusion rates surrounding at least a portion of the sensor in vivo.2. The device of claim 1 , wherein the biointerface comprises a spacer.3. The device of claim 2 , wherein the spacer comprises a mesh.4. The device of claim 2 , wherein the spacer comprises a hydrogel.5. The device of claim 4 , wherein the hydrogel comprises from about 20 wt. % to about 99 wt. % water.6. The device of claim 4 , wherein the hydrogel comprises from about 80 wt. % to about 99 wt. % water.7. The device of claim 2 , wherein the spacer comprises a shedding layer.8. The device of claim 2 , wherein the spacer is a fibrous structure.9. The device of claim 2 , wherein the spacer is a porous polymer membrane.10. The device of claim 2 , wherein the spacer comprises a material selected from the group consisting of polysulfone claim 2 , polytetrafluoroethylene claim 2 , polyvinylidene difluoride claim 2 , polyacrylonitrile claim 2 , silicone claim 2 , polytetrafluoroethylene claim 2 , expanded polytetrafluoroethylene claim 2 , polyethylene-co-tetrafluoroethylene claim 2 , polyolefin claim 2 , polyester claim 2 , polycarbonate claim 2 , biostable polytetrafluoroethylene claim 2 , polyurethane claim 2 , polypropylene claim 2 , ...

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Номер записи: 66
24-04-2014 дата публикации

ADVANCED ANALYTE SENSOR CALIBRATION AND ERROR DETECTION

Номер: US20140114153A1
Автор: Bohm Sebastian, Rong Daiting, Simpson Peter C.
Принадлежит: DexCom, Inc.

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors. 110-. (canceled)11. A method for identifying failure of an analyte sensor using a sensor system using electronics coupled to an analyte sensor , comprising:generating a data stream indicative of an analyte concentration of a host by applying a bias voltage to a first analyte sensor at least partially positioned within tissue of a host;applying a time-varying signal to the first analyte sensor;measuring a signal response to the stimulus signal;analyzing the signal response to determine whether the signal response satisfies one or more predetermined sensor fault criteria; andinitiating an error routine if the one or more predetermined sensor fault criteria are determined to be satisfied.12. The method of claim 11 , wherein the error routine includes triggering one or more of an audible alarm and a visual alarm on a display screen.13. The method of claim 11 , wherein the stimulus signal has a predetermined frequency.14. The method of claim 11 , wherein the stimulus signal comprises a spectrum of frequencies.151. The method of claim claim 11 , further comprising calculating an impedance based on the signal response.16. The ...

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Номер записи: 67
24-04-2014 дата публикации

ADVANCED ANALYTE SENSOR CALIBRATION AND ERROR DETECTION

Номер: US20140114156A1
Автор: Bohm Sebastian, Rong Daiting, Simpson Peter C.
Принадлежит: DexCom, Inc.

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors. 110-. (canceled)11. A method for determining reuse of an analyte sensor using sensor electronics coupled to the sensor , comprising:generating a data stream indicative of an analyte concentration of a host by applying a bias voltage to a first analyte sensor at least partially positioned within tissue of a host;applying a stimulus signal to the analyte sensor;measuring a response of the stimulus signal;comparing the measured response to one or more predetermined criteria; andinitiating a sensor reuse routine if it is determined that the measured response satisfies the one or more predetermined criteria.12. The method of claim 11 , wherein the sensor reuse routine includes triggering an audible and/or visual alarm notifying the user of improper sensor reuse.13. The method of claim 11 , wherein the sensor reuse routing includes causing a sensor system to fully or partially shut down and/or cease display of sensor data on a user interface of the sensor system.14. The method of claim 11 , further comprising calculating an impedance based on the measured response claim 11 , wherein the comparing comprises comparing the impedance ...

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Номер записи: 68
24-04-2014 дата публикации

DUAL ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR

Номер: US20140114159A1
Автор: Brister Mark, Petisce James R., SIMPSON Peter
Принадлежит: DexCom, Inc.

Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data. 116-. (canceled)17. An implantable continuous glucose sensor comprising:a first conductive layer comprising a first electrode;a first insulative layer covering at least a portion of the first conductive layer; anda second conductive layer covering at least a portion of the first insulative layer, wherein the second conductive layer comprises a second electrode;a second insulative layer covering at least a portion of the second conductive layer;a third conductive layer covering at least a portion of the second insulative layer, wherein the third conductive layer comprises a third electrode;wherein the first electrode, the second electrode, and the third electrode are staggered along a longitudinal axis defined by the first conductive layer such that the second electrode extends vertically beyond the first electrode and the third electrode extends vertically beyond the second electrode.18. The sensor of claim 17 , wherein at least one of the first electrode claim 17 , second electrode claim 17 , or third electrode is a working electrode.19. The sensor of claim 17 , wherein at least one of the first electrode claim 17 , second electrode claim 17 , or third electrode is a working electrode.20. The sensor of claim 19 , further comprising a membrane disposed over the working electrode claim 19 , wherein the membrane comprises a first domain configured to reduce a flux of glucose therethrough claim 19 , wherein the first domain comprises a product of a reaction of an isocyanate compound with a compound comprising a hydroxyl group and/or a ...

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Номер записи: 69
30-01-2020 дата публикации

DUAL ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR

Номер: US20200029876A1
Автор: Brister Mark C., Petisce James R., Simpson Peter C.
Принадлежит:

Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data. 120-. (canceled)21. A transcutaneous analyte sensor configured for insertion into a host for measuring an analyte in the host , the sensor comprising:a first conductive layer comprising a working electrode, wherein the working electrode is configured to generate a signal indicative of an analyte concentration;a first insulative layer covering at least a portion of the first conductive layer;a second conductive layer covering at least a portion of the first insulative layer, wherein the second conductive layer comprises a reference or counter electrode;a second insulative layer covering at least a portion of the second conductive layer;a membrane covering at least a portion of the first electrode, wherein the membrane comprises a silicone-urethane copolymer and an acrylate polymer; andelectronics operably connected to the working electrode and the reference electrode and configured to process the first signal.22. The sensor of claim 21 , wherein the sensor is configured for implantation into the host.23. The sensor of claim 22 , wherein the sensor is configured for subcutaneous implantation in a tissue of the host.24. The sensor of claim 22 , wherein the sensor is configured for indwelling in a blood stream of the host.25. The sensor of claim 21 , wherein the sensor substantially continuously measures an analyte concentration of the host.26. The sensor of claim 21 , wherein the working electrode and the reference electrode integrally form a substantial portion of the sensor configured for insertion in the host.27. The sensor of ...

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Номер записи: 70
05-02-2015 дата публикации

APPARATUS AND METHODS FOR TAR REMOVAL FROM SYNGAS

Номер: US20150037229A1
Автор: Bell Peter Simpson, Descales Bernard, Eyraud Julien, Golab Joseph, Ko Ching-Whan
Принадлежит: INEOS BIO SA

A process and apparatus are provided for reducing content of tar in a tar containing syngas. The process includes contacting the tar containing syngas with a molecular oxygen containing gas in a first reaction zone to produce a gas mixture. The gas mixture is passed through a heat treatment zone maintained at a temperature between about 900° C. to about 2000° C. for a contact time of about 0.5 to about 5 seconds. In this aspect, at least a portion of the tar undergoes at least partial oxidation and/or cracking to produce a hot syngas.

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Номер записи: 71
11-02-2016 дата публикации

PARTICLE-CONTAINING MEMBRANE AND PARTICULATE ELECTRODE FOR ANALYTE SENSORS

Номер: US20160038065A1
Автор: Boock Robert J., Simpson Peter C., Wightlin Matthew D.
Принадлежит:

Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 120-. (canceled)21. A system for measuring an analyte concentration in a host , the system comprising:a working electrode configured to be implanted in a host, wherein the electrode comprises rhodium;a membrane disposed over the electrode, wherein the membrane comprises an enzyme; andsensor electronics configured to generate a signal indicative of a concentration of the species in the host.22. The system of claim 21 , wherein the sensor electronics are configured to apply a potential of from about 0.1V to about 0.8V is applied to the working electrode.23. The system of claim 22 , wherein the sensor electronics are configured to apply a potential of from about 0.3V to about 0.7V to the working electrode.24. The system of claim 23 , wherein the sensor electronics are configured to apply a potential of from about 0.3V to about 0.5V to the working electrode.25. The system of claim 24 , wherein the potential applied is constant.26. The system of claim 22 , wherein potential applied is cyclical claim 22 , pulsed claim 22 , intermittent claim 22 , variable claim 22 , or a combination thereof.27. The system of claim 21 , wherein the membrane comprises polyurethane.28. The system of claim 21 , where the analyte is glucose.29. The system of claim 21 , wherein the analyte is lactate.30. The system of claim 21 , wherein the enzyme is glucose oxidase.31. The system of claim 21 , wherein the working electrode comprises conductive particles that form a network and function as an array of microelectrodes.32. The system of claim 21 , wherein the rhodium is disposed on a substrate.33. The system of claim 32 , wherein the substrate is formed of a metal.34. The system of claim 33 , wherein the ...

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Номер записи: 72
24-02-2022 дата публикации

ANALYTE SENSOR

Номер: US20220054055A1
Автор: Brauker James H., Brister Mark C., Goode, Ha Victor, JR. Paul V., Kamath Apurv Ullas, Mahalingam Aarthi, Masterson Steve, Nicholas Melissa A., NOLTING John, Petisce James R., Pryor Jack, SAINT Sean, Simpson Peter C., SWANSON Vance, Wightlin Matthew D., Woo Kum Ming
Принадлежит:

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 1. An analyte monitoring system , the system comprising: a first wire comprising a working electrode configured to generate a signal indicative of an analyte concentration;', 'a second wire comprising a reference electrode; and', 'a third wire comprising a counter electrode; and, "an electrochemical sensor configured to measure a level of an analyte in a biological sample from a patient, wherein the biological sample is a tear, wherein the sensor is configured to be fastened to a portion of a patient's body, wherein the sensor is configured to be powered by inductive coupling, wherein the sensor comprises:"}sensor electronics configured to operatively connect to the sensor, wherein the sensor electronics are configured to process data obtained from the sensor.2. The system of claim 1 , wherein the first wire claim 1 , second wire claim 1 , and third wire are formed of metal.3. The system of claim 1 , wherein the first wire comprises platinum.4. The system of claim 1 , wherein the second wire comprises silver/silver chloride.5. The system of claim 1 , wherein the third wire comprises platinum.6. The system of claim 1 , wherein at least one of the first wire claim 1 , second wire claim 1 , or third wire is in a coiled configuration during sensor use.7. The system of claim 1 , wherein the sensor further comprises a membrane comprising an enzyme configured to react with the analyte claim 1 , wherein at least a portion of the working electrode is covered by the membrane.8. The system of claim 7 , wherein the enzyme is configured to react with glucose to produce hydrogen peroxide.9. The system of claim 8 , wherein the working electrode is configured to oxidize hydrogen peroxide to generate the signal indicative of the analyte concentration.10. The ...

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Номер записи: 73
24-02-2022 дата публикации

ANALYTE SENSOR

Номер: US20220054056A1
Автор: Brauker James H., Brister Mark C., Goode, Ha Victor, JR. Paul V., Kamath Apurv Ullas, Mahalingam Aarthi, Masterson Steve, Nicholas Melissa A., NOLTING John, Petisce James R., Pryor Jack, SAINT Sean, Simpson Peter C., SWANSON Vance, Wightlin Matthew D., Woo Kum Ming
Принадлежит:

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 1. An analyte monitoring system , the system comprising: a first wire comprising a working electrode configured to generate a signal indicative of an analyte concentration;', 'a second wire comprising a reference electrode; and', 'a third wire comprising a counter electrode; and, "an electrochemical sensor configured to measure a level of an analyte in a biological sample from a patient, wherein the biological sample is a tear, wherein the sensor is configured to be fastened to a portion of a patient's body, wherein the sensor is configured to be powered by inductive coupling, wherein the sensor comprises:"}sensor electronics configured to operatively connect to the sensor, wherein the sensor electronics are configured to process data obtained from the sensor.2. The system of claim 1 , wherein the first wire claim 1 , second wire claim 1 , and third wire are formed of metal.3. The system of claim 1 , wherein the first wire comprises platinum.4. The system of claim 1 , wherein the second wire comprises silver/silver chloride.5. The system of claim 1 , wherein the third wire comprises platinum.6. The system of claim 1 , wherein at least one of the first wire claim 1 , second wire claim 1 , or third wire is in a coiled configuration during sensor use.7. The system of claim 1 , wherein the sensor further comprises a membrane comprising an enzyme configured to react with the analyte claim 1 , wherein at least a portion of the working electrode is covered by the membrane.8. The system of claim 7 , wherein the enzyme is configured to react with glucose to produce hydrogen peroxide.9. The system of claim 8 , wherein the working electrode is configured to oxidize hydrogen peroxide to generate the signal indicative of the analyte concentration.10. The ...

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Номер записи: 74
06-02-2020 дата публикации

ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE

Номер: US20200037874A1
Автор: Boock Robert J., Brister Mark C., Brunner Seth R., Chee Arthur, Markovic Dubravka, Nguyen Lisa, Nicholas Melissa A., Pryor Jack, Rixman Monica A., Simpson Peter C., Wightlin Matthew D., Woo Kum Ming
Принадлежит:

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 126-. (canceled)27. A transcutaneous electrochemical glucose sensor configured for implantation in a host , the transcutaneous electrochemical glucose sensor comprising:a first portion configured to remain outside a body of the host during sensor use; and a working electrode comprising a plurality of sensing regions; and', 'a reference electrode disposed at least in part on the second portion of the transcutaneous electrochemical glucose sensor., 'a second portion configured to be inserted inside the body of the host during sensor use, wherein the second portion comprises28. The transcutaneous electrochemical glucose sensor of claim 27 , wherein the membrane comprises a layer configured to control a diffusion of glucose therethrough.29. The transcutaneous electrochemical glucose sensor of claim 27 , wherein the layer comprises polyurethane.30. The transcutaneous electrochemical glucose sensor of claim 27 , wherein the transcutaneous electrochemical glucose sensor has a planar shape.31. The transcutaneous electrochemical glucose sensor of claim 27 , wherein the reference electrode further comprises silver and silver chloride.32. The transcutaneous electrochemical glucose sensor of claim 27 , further comprising a counter electrode disposed at least in part on the second portion of the transcutaneous electrochemical glucose sensor.33. The transcutaneous electrochemical sensor of claim 27 , wherein each of the plurality of sensing regions comprises a membrane.34. The transcutaneous electrochemical sensor of claim 33 , wherein the membrane comprises an enzyme.35. The transcutaneous electrochemical sensor of claim 33 , wherein the ...

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Номер записи: 75
06-02-2020 дата публикации

ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE

Номер: US20200037875A1
Автор: Boock Robert J., Brister Mark C., Brunner Seth R., Chee Arthur, Markovic Dubravka, Nguyen Lisa, Nicholas Melissa A., Pryor Jack, Rixman Monica A., Simpson Peter C., Wightlin Matthew D., Woo Kum Ming
Принадлежит:

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 120-. (canceled)21. A transcutaneous electrochemical glucose sensor configured for implantation in a host , the transcutaneous electrochemical glucose sensor comprising:a first portion configured to remain outside a body of the host during sensor use, wherein the first portion is configured to operably connect with sensor electronics; and a planar substrate;', 'a working electrode disposed over at least a portion of the planar substrate;', 'a membrane layer disposed over at least a portion of the working electrode; and', 'a reference electrode disposed at least in part on the second portion of the transcutaneous electrochemical glucose sensor,, 'a second portion configured to be inserted inside the body of the host during sensor use, wherein the second portion comprises22. The transcutaneous electrochemical glucose sensor of claim 21 , wherein the membrane layer is configured to control a diffusion of glucose therethrough.23. The transcutaneous electrochemical glucose sensor of claim 21 , wherein the membrane layer comprises polyurethane.24. The transcutaneous electrochemical glucose sensor of claim 21 , wherein the transcutaneous electrochemical glucose sensor has a planar shape.25. The transcutaneous electrochemical glucose sensor of claim 21 , wherein the reference electrode comprises silver and silver chloride.26. The transcutaneous electrochemical glucose sensor of claim 21 , further comprising a counter electrode disposed at least in part on the second portion of the transcutaneous electrochemical glucose sensor. Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby ...

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Номер записи: 76
06-02-2020 дата публикации

ADVANCED ANALYTE SENSOR CALIBRATION AND ERROR DETECTION

Номер: US20200037934A1
Автор: Bohm Sebastian, Rong Daiting, Simpson Peter C.
Принадлежит:

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors. 1. A method for calibrating an analyte sensor , the method comprising:applying a time-varying signal to the analyte sensor;measuring a signal response to the applied signal;determining, using sensor electronics, a sensitivity of the analyte sensor, the determining comprising correlating at least one property of the signal response to a predetermined sensor sensitivity profile; andgenerating, using sensor electronics, estimated analyte concentration values using the determined sensitivity and sensor data generated by the analyte sensor.2. The method of claim 1 , wherein the sensitivity profile comprises varying sensitivity values over time since implantation of the sensor.3. The method of claim 1 , wherein the predetermined sensitivity profile comprises a plurality of sensitivity values.4. The method of claim 1 , wherein the predetermined sensitivity profile is based on sensor sensitivity data generated from studying sensitivity changes of analyte sensors similar to the analyte sensor.5. The method of claim 1 , further comprising applying a bias voltage to the sensor claim 1 , wherein the time-varying signal comprises a step ...

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Номер записи: 77
06-02-2020 дата публикации

ADVANCED ANALYTE SENSOR CALIBRATION AND ERROR DETECTION

Номер: US20200037935A1
Автор: Bohm Sebastian, Rong Daiting, Simpson Peter C.
Принадлежит:

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors. 1. A method for calibrating an analyte sensor , the method comprising:applying a time-varying signal to the analyte sensor;measuring a signal response to the applied signal;determining, using sensor electronics, a sensitivity of the analyte sensor, the determining comprising correlating at least one property of the signal response to a predetermined sensor sensitivity profile; andgenerating, using sensor electronics, estimated analyte concentration values using the determined sensitivity and sensor data generated by the analyte sensor.2. The method of claim 1 , wherein the sensitivity profile comprises varying sensitivity values over time since implantation of the sensor.3. The method of claim 1 , wherein the predetermined sensitivity profile comprises a plurality of sensitivity values.4. The method of claim 1 , wherein the predetermined sensitivity profile is based on sensor sensitivity data generated from studying sensitivity changes of analyte sensors similar to the analyte sensor.5. The method of claim 1 , further comprising applying a bias voltage to the sensor claim 1 , wherein the time-varying signal comprises a step ...

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Номер записи: 78
06-02-2020 дата публикации

ADVANCED ANALYTE SENSOR CALIBRATION AND ERROR DETECTION

Номер: US20200037936A1
Автор: Bohm Sebastian, Rong Daiting, Simpson Peter C.
Принадлежит:

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors. 120-. (canceled)21. A method of making a glucose concentration measuring system for use by a host during a sensor session with a transcutaneously implanted glucose sensor , the method comprising:applying a membrane to an electrode of a transcutaneous glucose sensor;obtaining data about a characteristic of the transcutaneous glucose sensor prior to a sensor session in a host; andassigning a calibration code to the transcutaneous glucose sensor.22. The method of claim 21 , wherein the calibration code is part of a calibration encoded label.23. The method of claim 21 , wherein the transcutaneous glucose sensor is formed as a wire.24. The method of claim 21 , further comprising measuring a length of time the transcutaneous glucose sensor was dipped in a particular coating solution claim 21 , and wherein the calibration code is further based at least in part on the measured dipping length of time.25. The method of claim 21 , further comprising measuring a curing temperature of the membrane claim 21 , and wherein the calibration code is further based at least in part on the measured curing temperature. Any and all priority claims ...

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Номер записи: 79
06-02-2020 дата публикации

RECEIVERS FOR ANALYZING AND DISPLAYING SENSOR DATA

Номер: US20200037965A1
Автор: Chico Holly, Constantine Kassandra, Hall Thomas, Hampapuram Hari, JOHNSON Eric, Mensinger Michael Robert, Reihman Eli, Simpson Peter C., Snisarenko Kostyantyn
Принадлежит:

This disclosure provides systems, methods and apparatus for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor. The system may include a display device with at least one input device. In response to movement of or along the input device, the display device may change a glucose data output parameter and update an output of the display device using the changed output parameter. 1. A glucose monitoring system comprising: a storage device configured to store at least some of the displayable sensor information;', 'a display; and', 'at least one input device;', 'wherein the display device is configured to detect movement of or along the at least one input device,', 'wherein the display device is configured to change a glucose data output parameter in response to the detected movement, and', 'wherein the display device is configured to update an output of glucose data using the changed glucose data output parameter., 'a display device configured to receive displayable sensor information from a sensor electronics module physically connected to a continuous analyte sensor, wherein the display device comprises2. The glucose monitoring system of claim 1 , wherein the at least one input device comprises a touchscreen.3. The glucose monitoring system of claim 1 , wherein the at least one input device comprises a circular touch sensitive input device.4. The glucose monitoring system of claim 1 , wherein the display device is configured to display a glucose chart displaying glucose information for a period of time.5. The glucose monitoring system of claim 4 , wherein the glucose data output parameter comprises the period of time for which glucose information is displayed.6. The glucose monitoring system of claim 4 , wherein the glucose chart is configured to display an estimate of a future glucose value.7. The glucose monitoring system of claim 4 , wherein the glucose data output parameter comprises a zoom level claim 4 , and ...

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Номер записи: 80
18-02-2021 дата публикации

ANALYTE SENSOR

Номер: US20210045663A1
Автор: Brauker James H., Brister Mark C., Goode, JR. Paul V., Kamath Apurv Ullas, Mahalingam Aarthi, Pryor Jack, Simpson Peter C., Wightlin Matthew D.
Принадлежит:

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 112-. (canceled)13. A system for measuring an analyte concentration in a host , the system comprising:a transcutaneous analyte sensor; andsensor electronics configured to operatively connect to the transcutaneous analyte sensor.14. A method for processing data from a transcutaneous analyte sensor , the method comprising:receiving sensor data indicative of an analyte concentration in the host; andprocessing, using a processor, the sensor data. Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 16/924,117, filed Jul. 8, 2020, which is a continuation of U.S. application Ser. No. 16/691,358, filed Nov. 21, 2019, now U.S. Pat. No. 10,709,362, which is a continuation of U.S. application Ser. No. 16/674,610, filed Nov. 5, 2019, now U.S. Pat. No. 10,722,152, which is a continuation of U.S. application Ser. No. 16/392,521, filed Apr. 23, 2019, which is a continuation of U.S. application Ser. No. 14/590,483, filed Jan. 6, 2015, now U.S. Pat. No. 10,314,525, which is a continuation of U.S. application Ser. No. 13/909,962, filed Jun. 4, 2013, now U.S. Pat. No. 9,247,900, which is a continuation of U.S. application Ser. No. 11/360,262, filed Feb. 22, 2006, now U.S. Pat. No. 8,615,282. Each of the aforementioned applications is incorporated by reference herein in its entirety, and each is hereby expressly made a part of this specification. The aforementioned application is incorporated by reference herein in its entirety, and is hereby expressly made a part of this specification.The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, ...

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Номер записи: 81
18-02-2021 дата публикации

ANALYTE SENSOR

Номер: US20210045665A1
Автор: Brauker James H., Brister Mark C., Goode, JR. Paul V., Kamath Apurv Ullas, Mahalingam Aarthi, Pryor Jack, Simpson Peter C., Wightlin Matthew D.
Принадлежит:

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 112-. (canceled)13. A system for measuring an analyte concentration in a host , the system comprising:a transcutaneous analyte sensor; andsensor electronics configured to operatively connect to the transcutaneous analyte sensor.14. A method for processing data from a transcutaneous analyte sensor , the method comprising:receiving sensor data indicative of an analyte concentration in the host; andprocessing, using a processor, the sensor data. Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 16/924,117, filed Jul. 8, 2020, which is a continuation of U.S. application Ser. No. 16/691,358, filed Nov. 21, 2019, now U.S. Pat. No. 10,709,362, which is a continuation of U.S. application Ser. No. 16/674,610, filed Nov. 5, 2019, now U.S. Pat. No. 10,722,152, which is a continuation of U.S. application Ser. No. 16/392,521, filed Apr. 23, 2019, which is a continuation of U.S. application Ser. No. 14/590,483, filed Jan. 6, 2015, now U.S. Pat. No. 10,314,525, which is a continuation of U.S. application Ser. No. 13/909,962, filed Jun. 4, 2013, now U.S. Pat. No. 9,247,900, which is a continuation of U.S. application Ser. No. 11/360,262, filed Feb. 22, 2006, now U.S. Pat. No. 8,615,282. Each of the aforementioned applications is incorporated by reference herein in its entirety, and each is hereby expressly made a part of this specification. The aforementioned application is incorporated by reference herein in its entirety, and is hereby expressly made a part of this specification.The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, ...

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Номер записи: 82
18-02-2021 дата публикации

ANALYTE SENSOR

Номер: US20210045666A1
Автор: Brauker James H., Brister Mark C., Goode, JR. Paul V., Kamath Apurv Ullas, Mahalingam Aarthi, Pryor Jack, Simpson Peter C., Wightlin Matthew D.
Принадлежит:

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 112-. (canceled)13. A system for measuring an analyte concentration in a host , the system comprising:a transcutaneous analyte sensor; andsensor electronics configured to operatively connect to the transcutaneous analyte sensor.14. A method for processing data from a transcutaneous analyte sensor , the method comprising:receiving sensor data indicative of an analyte concentration in the host; andprocessing, using a processor, the sensor data. Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 16/924,117, filed Jul. 8, 2020, which is a continuation of U.S. application Ser. No. 16/691,358, filed Nov. 21, 2019, now U.S. Pat. No. 10,709,362, which is a continuation of U.S. application Ser. No. 16/674,610, filed Nov. 5, 2019, now U.S. Pat. No. 10,722,152, which is a continuation of U.S. application Ser. No. 16/392,521, filed Apr. 23, 2019, which is a continuation of U.S. application Ser. No. 14/590,483, filed Jan. 6, 2015, now U.S. Pat. No. 10,314,525, which is a continuation of U.S. application Ser. No. 13/909,962, filed Jun. 4, 2013, now U.S. Pat. No. 9,247,900, which is a continuation of U.S. application Ser. No. 11/360,262, filed Feb. 22, 2006, now U.S. Pat. No. 8,615,282. Each of the aforementioned applications is incorporated by reference herein in its entirety, and each is hereby expressly made a part of this specification. The aforementioned application is incorporated by reference herein in its entirety, and is hereby expressly made a part of this specification.The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, ...

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Номер записи: 83
16-02-2017 дата публикации

RECEIVERS FOR ANALYZING AND DISPLAYING SENSOR DATA

Номер: US20170042487A1
Автор: Chico Holly, Constantine Kassandra, Hall Thomas, Hampapuram Hari, JOHNSON Eric, Mensinger Michael Robert, Reihman Eli, Simpson Peter C., Snisarenko Kostyantyn
Принадлежит:

This disclosure provides systems, methods and apparatus for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor. The system may include a display device with at least one input device. In response to movement of or along the input device, the display device may change a glucose data output parameter and update an output of the display device using the changed output parameter. 120-. (canceled)21. A glucose monitoring system for monitoring a host's glucose levels , the system comprising a computing device having a touch-sensitive display , wherein the computing device is configured to:display on the touch-sensitive display a first chart and a second chart adjacent to one another, each chart having a y-axis in units of an analyte concentration and an x-axis in units of time, and each x-axis of the first and second charts extending different periods of time, wherein the x-axis of the first chart extends a first period of time and the x-axis of the second chart extends a second period of time, the first period of time being a sub-set of the second period of time, and wherein the second chart additionally comprises an indication of the first time period.22. The computing device of claim 21 , wherein the computing device is further configured to change the first time period in response to the computing device detecting a predefined user input.23. The computing device of claim 22 , wherein the predefined user input comprises a predefined user gesture on the user interface.24. The computing device of claim 23 , wherein the predefined user gesture comprises a tap on the display claim 23 , a swipe on the display claim 23 , or a selection and dragging of an icon on the display.25. The computing device of claim 21 , wherein the indication of the first time period comprises a bar extending along the y-axis of the second chart claim 21 , and wherein the bar moves along the x-axis of the second chart responsive to a user changing ...

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Номер записи: 84
15-02-2018 дата публикации

SENSORS FOR CONTINUOUS ANALYTE MONITORING, AND RELATED METHODS

Номер: US20180042529A1
Автор: Blackwell Jennifer, Bohm Sebastian, Estes Michael J., Jackson Jeff, Mitchell Jason, Pryor Jack, Rong Daiting, Saint Sean T., Sheth Disha B., Simpson Peter C., Wang Shanger
Принадлежит:

Sensor devices including dissolvable tissue-piercing tips are provided. The sensor devices can be used in conjunction with dissolvable needles configured for inserting the sensor devices into a host. Hardening agents for strengthening membranes on sensor devices are also provided. Methods of using and fabricating sensor devices are also provided. 1. A method of making a sensor device configured for implantation in a host without use of an inserter , the method comprising:forming a piercing tip on a sensor unit, the sensor unit including a sensor body, at least one electrode, and a membrane covering at least a portion of the at least one electrode;wherein the membrane is applied to the sensor unit prior to forming the piercing tip on the sensor unit.2. The method of claim 1 , further comprising applying the membrane to the sensor unit.3. The method of claim 1 , wherein forming the piercing tip comprises forming an annular channel about a circumference of a wire that is coated with the membrane.4. The method of claim 3 , wherein the annular channel extends through the membrane and partially into the wire.5. The method of claim 3 , further comprising applying tension to the coated wire.6. The method of claim 5 , wherein the tension induces strain in the wire proximate the annular channel claim 5 , causing the wire to neck and fracture.7. The method of claim 6 , wherein the necking forms the piercing tip on the sensor body.8. The method of claim 7 , further comprising covering the piercing tip with a protective outer layer. Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a divisional of U.S. application Ser. No. 14/250,320, filed on Apr. 10, 2014. The aforementioned application is incorporated by reference herein in its entirety, and is hereby expressly made a part of this specification.The present embodiments relate to systems and methods for ...

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Номер записи: 85
15-02-2018 дата публикации

ADVANCED ANALYTE SENSOR CALIBRATION AND ERROR DETECTION

Номер: US20180042530A1
Автор: Bohm Sebastian, Rong Daiting, Simpson Peter C.
Принадлежит:

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors. 1. A method for determining whether an analyte sensor system is functioning properly , the method comprising:applying a stimulus signal to the analyte sensor;measuring a response to the stimulus signal;estimating a value of a sensor property based on the signal response;correlating the sensor property value with a predetermined relationship of the sensor property and a predetermined sensor sensitivity profile.initiating an error routine if the correlation does not exceed a predetermined correlation threshold.2. The method of claim 1 , wherein correlating includes performing a data association analysis.3. The method of claim 1 , wherein the error routine comprises displaying a message to a user indicating that the analyte sensor is not functioning properly.4. The method of claim 1 , wherein the sensor property is an impedance of the sensor membrane.5. A sensor system configured to implement the method of .6. The sensor system of claim 1 , wherein the sensor system comprises instructions stored in computer memory claim 1 , wherein the instructions claim 1 , when executed by one or more processors of the sensor system claim 1 ...

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Номер записи: 86
15-02-2018 дата публикации

SYSTEMS AND METHODS FOR HEALTH DATA VISUALIZATION AND USER SUPPORT TOOLS FOR CONTINUOUS GLUCOSE MONITORING

Номер: US20180042558A1
Автор: Armenta Lauren Danielle, Belliveau Scott M., Blackwell Jennifer, Bowman Leif N., Cabrera, Draeger Rian, Garcia Arturo, Goldsmith Timothy Joseph, Gray John Michael, Jackson Andrea Jean, JR. Esteban, Kamath Apurv Ullas, Koehler Katherine Yerre, Kramer Paul, Mandapaka Aditya Sagar, Mensinger Michael Robert, Mikami Sumitaka, MORRIS Gary A., Nirmal Hemant Mahendra, Noble-Campbell Paul, Pupa Philip Thomas, Reihman Eli, Simpson Peter C., Smith Brian Christopher, Wiley Atiim Joseph
Принадлежит:

Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host. 1. A system , comprising:a continuous analyte sensor configured to obtain analyte measurements of a host;a wireless transmitter configured to receive the analyte measurements from the continuous analyte sensor and at least partially process the analyte measurements to produce one or more datasets of analyte data, each dataset comprising an analyte concentration value associated with a time for one or more of the analyte measurements, wherein the wireless transmitter comprises an energy storage unit, a data converter unit, a processing unit and a transmitter unit; andan analyte data processing module operable on a mobile computing device in wireless communication with the wireless transmitter, the analyte data processing module configured to receive and process the one or more datasets from the wireless transmitter to produce a graphical display on the mobile computing device, wherein the graphical display comprises an arrangement of the analyte concentration values over a plurality of time intervals that is graphically modified to indicate one or more patterns in analyte data.2. The system of claim 1 , wherein the analyte data processing module is further configured to:aggregate groups of analyte data;flag the groups of analyte data based on additional information corresponding to one or more graphical displays;arrange the flagged groups of analyte concentration values; andgenerate a self-referential dataset from the arranged groups of analyte concentration values.3. The system of claim 2 , wherein generation of the self-referential dataset further comprises one or more of:flagging the analyte data based on one or ...

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Номер записи: 87
15-02-2018 дата публикации

SYSTEMS AND METHODS FOR HEALTH DATA VISUALIZATION AND USER SUPPORT TOOLS FOR CONTINUOUS GLUCOSE MONITORING

Номер: US20180042559A1
Автор: Armenta Lauren Danielle, Belliveau Scott M., Blackwell Jennifer, Bowman Leif N., Cabrera, Draeger Rian, Garcia Arturo, Goldsmith Timothy Joseph, Gray John Michael, Jackson Andrea Jean, JR. Esteban, Kamath Apurv Ullas, Koehler Katherine Yerre, Kramer Paul, Mandapaka Aditya Sagar, Mensinger Michael Robert, Mikami Sumitaka, MORRIS Gary A., Nirmal Hemant Mahendra, Noble-Campbell Paul, Pupa Philip Thomas, Reihman Eli, Simpson Peter C., Smith Brian Christopher, Wiley Atiim Joseph
Принадлежит:

Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host. 1. A system comprising:a continuous analyte sensor configured to obtain glucose data of a host; a wireless transmitter configured to receive the glucose data from the continuous analyte sensor and transmit the glucose data to a processing module;the processing module further configured to receive insulin data of the host, the glucose data of the host, and event data of the host and to produce a graphical display on a mobile computing device,wherein the processing module further modifies the graphical display to display a visual indicating one or more relationships of the insulin data, the glucose data, the event data with each other or time, wherein the visual is scaled to not obscure the display of the insulin, glucose or event data.2. The system of claim 1 , wherein the event data includes one or more of insulin dosing claim 1 , carbohydrate intake claim 1 , or exercise.3. The system of claim 1 , wherein the insulin data includes an insulin on board value claim 1 , and the visual comprises a colored ring indicating the insulin on board and an estimated time remaining for the insulin on board.4. The system of claim 1 , wherein the visual comprises a trend graph of the glucose data and an interactive call out window associated with a region or a feature of the trend graph that is presented when a user selects the region or the feature of the trend graph on the graphical display claim 1 , wherein the presented call-out window comprises at least some of the insulin data or the event data.5. The system of claim 4 , wherein the presented call-out window is configured to display a graphical arrangement of the insulin ...

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Номер записи: 88
18-02-2016 дата публикации

PROCESS FOR CONTROLLING FERMENTATION OF CO-CONTAINING SUBSTRATES

Номер: US20160047007A1
Автор: Bell Peter Simpson, Liu Song
Принадлежит: INEOS BIO SA

A process for stable fermentation of CO-containing substrates and improved ethanol productivity includes providing medium components in amounts needed by microorganisms in the fermentation. The process includes determining a potassium concentration in the fermentation medium and providing a first medium and a second medium to the fermentation, the first medium provided at a rate effective for maintaining the potassium in the fermentation medium in a range of about 20 to about 200 mg/L until reaching a target cell density. 1. A process for controlling fermentation of a CO-containing substrate , the process comprising:providing the CO-containing substrate to a fermentation and fermenting the CO-containing substrate; andmonitoring nutrient concentration in a fermentation medium using a technique selected from the group consisting of ion chromatography, inductively coupled plasma spectrometry, ion-selective electrodes, flame photometry, flame ionization atomic absorption and combinations thereof.2. The process of wherein the nutrients being monitored are selected from the group consisting of K claim 1 , Mg claim 1 , PO claim 1 , Fe claim 1 , Zn claim 1 , Ni claim 1 , Co and mixtures thereof.3. The process of wherein the nutrient being monitored are K claim 2 , PO claim 2 , Mg and mixtures thereof.4. The process of wherein the technique used to monitor nutrient concentration is ion chromatography.5. The process of wherein the process provides a target cell density is about 2 to about 30 g/L.6. The process of wherein the fermentation medium includes a first and a second nutrient containing medium.7. The process of wherein the first medium is provided to the fermentation at a rate effective for maintaining a potassium concentration in the medium of about 20 to about 200 mg/L until reaching the target cell density.8. The process of wherein the first medium is provided to the fermentation at a rate effective for maintaining a potassium concentration in the medium of about 20 ...

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Номер записи: 89
03-03-2022 дата публикации

TRANSCUTANEOUS ANALYTE SENSOR SYSTEMS AND METHODS

Номер: US20220061716A1
Автор: Blackwell Jennifer, England Justen Deering, Gray John Michael, Halac Jason, Johnston Neal Davis, Kempkey Mark Douglas, Neale Paul V., Pirondini Kenneth, Reinhardt Andrew Michael, Simpson Peter C., Wells Maria Noel Brown
Принадлежит:

Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly. 1a transcutaneous analyte sensor; andsensor electronics operably connectable to the transcutaneous analyte sensor.. A transcutaneous analyte sensor system comprising: Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 17/378,491, filed Jul. 16, 2021, which is a continuation of U.S. application Ser. No. 17/200,620, filed Mar. 12, 2021, now U.S. Pat. No. 11,166,657, issued Nov. 9, 2021, which is a continuation of U.S. application Ser. No. 15/387,088, filed Dec. 21, 2016, which, in turn, claims the benefit of U.S. Provisional Application No. 62/272,983, filed Dec. 30, 2015 and U.S. Provisional Application No. 62/412,100, filed Oct. 24, 2016. Each of the aforementioned applications is incorporated by reference herein in its entirety, and each is hereby expressly made a part of this specification.Various embodiments disclosed herein relate to measuring an analyte in a person. Certain embodiments relate to systems and methods for applying a transcutaneous analyte measurement system to a person.Diabetes mellitus is a disorder in which the pancreas cannot create sufficient insulin (Type I or insulin dependent) and/or in which insulin is not effective (Type 2 or non-insulin dependent). In the diabetic state, the victim suffers from high blood sugar, which can cause an array of physiological derangements associated with the deterioration of small blood vessels, for example, kidney failure, skin ulcers, or bleeding into the vitreous of the eye ...

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Номер записи: 90
03-03-2022 дата публикации

TRANSCUTANEOUS ANALYTE SENSOR SYSTEMS AND METHODS

Номер: US20220061717A1
Автор: Blackwell Jennifer, England Justen Deering, Gray John Michael, Halac Jason, Johnston Neal Davis, Kempkey Mark Douglas, Neale Paul V., Pirondini Kenneth, Reinhardt Andrew Michael, Simpson Peter C., Wells Maria Noel Brown
Принадлежит:

Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly.

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Номер записи: 91
03-03-2022 дата публикации

TRANSCUTANEOUS ANALYTE SENSOR SYSTEMS AND METHODS

Номер: US20220061718A1
Автор: Blackwell Jennifer, England Justen Deering, Gray John Michael, Halac Jason, Johnston Neal Davis, Kempkey Mark Douglas, Neale Paul V., Pirondini Kenneth, Reinhardt Andrew Michael, Simpson Peter C., Wells Maria Noel Brown
Принадлежит:

Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly.

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Номер записи: 92
03-03-2022 дата публикации

TRANSCUTANEOUS ANALYTE SENSOR SYSTEMS AND METHODS

Номер: US20220061719A1
Автор: Blackwell Jennifer, England Justen Deering, Gray John Michael, Halac Jason, Johnston Neal Davis, Kempkey Mark Douglas, Neale Paul V., Pirondini Kenneth, Reinhardt Andrew Michael, Simpson Peter C., Wells Maria Noel Brown
Принадлежит:

Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly. 1a transcutaneous analyte sensor; andsensor electronics operably connectable to the transcutaneous analyte sensor.. A transcutaneous analyte sensor system comprising: Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 17/378,491, filed Jul. 16, 2021, which is a continuation of U.S. application Ser. No. 17/200,620, filed Mar. 12, 2021, now U.S. Pat. No. 11,166,657, issued Nov. 9, 2021, which is a continuation of U.S. application Ser. No. 15/387,088, filed Dec. 21, 2016, which, in turn, claims the benefit of U.S. Provisional Application No. 62/272,983, filed Dec. 30, 2015 and U.S. Provisional Application No. 62/412,100, filed Oct. 24, 2016. Each of the aforementioned applications is incorporated by reference herein in its entirety, and each is hereby expressly made a part of this specification.Various embodiments disclosed herein relate to measuring an analyte in a person. Certain embodiments relate to systems and methods for applying a transcutaneous analyte measurement system to a person.Diabetes mellitus is a disorder in which the pancreas cannot create sufficient insulin (Type I or insulin dependent) and/or in which insulin is not effective (Type 2 or non-insulin dependent). In the diabetic state, the victim suffers from high blood sugar, which can cause an array of physiological derangements associated with the deterioration of small blood vessels, for example, kidney failure, skin ulcers, or bleeding into the vitreous of the eye ...

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Номер записи: 93
03-03-2022 дата публикации

TRANSCUTANEOUS ANALYTE SENSOR SYSTEMS AND METHODS

Номер: US20220061720A1
Автор: Blackwell Jennifer, England Justen Deering, Gray John Michael, Halac Jason, Johnston Neal Davis, Kempkey Mark Douglas, Neale Paul V., Pirondini Kenneth, Reinhardt Andrew Michael, Simpson Peter C., Wells Maria Noel Brown
Принадлежит:

Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly. 1a transcutaneous analyte sensor; andsensor electronics operably connectable to the transcutaneous analyte sensor.. A transcutaneous analyte sensor system comprising: Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 17/378,491, filed Jul. 16, 2021, which is a continuation of U.S. application Ser. No. 17/200,620, filed Mar. 12, 2021, now U.S. Pat. No. 11,166,657, issued Nov. 9, 2021, which is a continuation of U.S. application Ser. No. 15/387,088, filed Dec. 21, 2016, which, in turn, claims the benefit of U.S. Provisional Application No. 62/272,983, filed Dec. 30, 2015 and U.S. Provisional Application No. 62/412,100, filed Oct. 24, 2016. Each of the aforementioned applications is incorporated by reference herein in its entirety, and each is hereby expressly made a part of this specification.Various embodiments disclosed herein relate to measuring an analyte in a person. Certain embodiments relate to systems and methods for applying a transcutaneous analyte measurement system to a person.Diabetes mellitus is a disorder in which the pancreas cannot create sufficient insulin (Type I or insulin dependent) and/or in which insulin is not effective (Type 2 or non-insulin dependent). In the diabetic state, the victim suffers from high blood sugar, which can cause an array of physiological derangements associated with the deterioration of small blood vessels, for example, kidney failure, skin ulcers, or bleeding into the vitreous of the eye ...

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Номер записи: 94
25-02-2021 дата публикации

TRANSCUTANEOUS ANALYTE SENSORS, APPLICATORS THEREFOR, AND ASSOCIATED METHODS

Номер: US20210052224A1
Автор: Apacible Daniel E., Baldwin Alan, Barry John Charles, Blackwell Jennifer, Brock Cameron, Castagna Patrick John, DeRenzy David, England Justen Deering, Gagnon Remy E., George Christian Michael Andre, Gray John Michael, Halac Jason, Joncich Andrew, Keller David A., Kempkey Mark Douglas, Koplin Randall Scott, Lee Young Woo, METZMAKER Thomas, Neale Paul V., Pirondini Kenneth, Reinhardt Andrew Michael, Shah Neel Narayan, Simpson Peter C., Sutherland Carol Wood, Terry Warren, van den Heuvel Louise Emma, Wells Maria Noel Brown, Wong Jason C.
Принадлежит:

The present embodiments relate generally to applicators of on-skin sensor assemblies for measuring an analyte in a host, as well as their method of use and manufacture. In some aspects, an applicator for applying an on-skin sensor assembly to a skin of a host is provided. The applicator includes an applicator housing, a needle carrier assembly comprising an insertion element configured to insert a sensor of the on-skin sensor assembly into the skin of the host, a holder releasably coupled to the needle carrier assembly and configured to guide the on-skin sensor assembly while coupled to the needle carrier assembly, and a drive assembly configured to drive the insertion element from a proximal starting position to a distal insertion position, and from the distal insertion position to a proximal retraction position. 1. An applicator for applying an on-skin sensor assembly to a skin of a host , the applicator comprising:a first body releasably coupled to a needle;a second body releasably coupled to the first body by a frictional engagement;a spring configured to provide a first force to the first body and second body, the first force driving the first body and second body in a distal direction; andwherein the frictional engagement is configured to be decoupled by a counter force applied to the on-skin sensor assembly in an opposite direction of the first force.2. The applicator of claim 1 , further comprising at least one retention element configured to frictionally couple the second body to the first body.3. The applicator of claim 2 , wherein the at least one retention element is formed integral with the second body.4. The applicator of claim 3 , wherein the at least one retention element is frictionally engaged against a wall of the first body.5. The applicator of claim 4 , wherein the counter force decouples the frictional engagement by displacing the at least one retention element from the wall of the first body.6. The applicator of claim 5 , wherein the wall is a ...

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Номер записи: 95
13-02-2020 дата публикации

ANALYTE SENSING BIOINTERFACE

Номер: US20200046273A1
Автор: Brauker James H., Simpson Peter C.
Принадлежит:

Disclosed herein is an analyte sensing biointerface that comprises a sensing electrode incorporated within a non-conductive matrix comprising a plurality of passageways extending through the matrix to the sensing electrode. Also disclosed herein are methods of manufacturing a sensing biointerface and methods of detecting an analyte within tissue of a host using an analyte sensing biointerface. 1. An implantable continuous glucose sensor system , comprising:a working electrode configured to measure a signal indicative of a glucose concentration;a membrane disposed on the working electrode, wherein the membrane comprises a biointerface, wherein the biointerface comprises an electrically conductive material, wherein the biointerface is configured to promote a foreign body response that will not substantially attack or attempt to block sensing of glucose; andelectronics electrically coupled to the working electrode.2. The sensor of claim 1 , wherein the biointerface comprises an enzyme.3. The sensor of claim 2 , wherein the biointerface further comprises a resistance domain disposed over the enzyme.4. The sensor of claim 1 , wherein the biointerface further comprises a bioactive agent.5. The sensor of claim 1 , wherein the biointerface is substantially planar. Any and all priority claims identified in the Application Data Sheet, or any correction thereto, are hereby incorporated by reference under 37 CFR 1.57. This application is a continuation of U.S. application Ser. No. 16/455,468, filed Jun. 27, 2019, which is a continuation of U.S. application Ser. No. 15/711,225, filed Sep. 21, 2017, now U.S. Pat. No. 10,376,188, which is a continuation of U.S. application Ser. No. 14/281,697, filed May 19, 2014, now U.S. Pat. No. 9,788,766, which is a continuation of U.S. application Ser. No. 13/285,880, filed Oct. 31, 2011, now abandoned, which is a continuation of U.S. application Ser. No. 11/404,929, filed Apr. 14, 2006, now U.S. Pat. No. 8,060,174, which claims the benefit of ...

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Номер записи: 96
08-05-2014 дата публикации

DUAL ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR

Номер: US20140128702A1
Автор: Brister Mark, Petisce James R., SIMPSON Peter
Принадлежит: DexCom, Inc.

Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data. 116-. (canceled)17. An implantable continuous glucose sensor comprising:a substrate;a first conductive material covering at least a portion of the substrate, wherein the first conductive material comprises a first electrode;a first insulative material covering at least a portion of the first conductive material;a second conductive material covering at least a portion of the first insulative material, wherein the second conductive material comprises a second electrode;a second insulative material covering at least a portion of the second conductive material; anda third conductive material covering at least a portion of the second insulative material, wherein the third conductive material comprises a third electrode.18. The sensor of claim 17 , wherein at least one of the first electrode claim 17 , second electrode claim 17 , or third electrode is a working electrode.19. The sensor of claim 18 , further comprising a membrane disposed over the working electrode claim 18 , wherein the membrane comprises a first domain configured to reduce a flux of glucose therethrough claim 18 , wherein the first domain comprises a product of a reaction of an isocyanate compound with a compound comprising a hydroxyl group and/or a compound comprising an amine group.20. The sensor of claim 19 , wherein the membrane further comprises a second domain claim 19 , wherein the second domain comprises an enzyme configured to react with glucose.21. The sensor of claim 17 , wherein at least one of the first electrode claim 17 , second electrode claim 17 , or ...

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Номер записи: 97
08-05-2014 дата публикации

ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE

Номер: US20140128703A1
Автор: Boock Robert J., Brister Mark C., Brunner Seth R., Chee Arthur, Markovic Dubravka, Nguyen Lisa, Nicholas Melissa A., Pryor Jack, Rixman Monica A., Simpson Peter C., Wightlin Matthew D., Woo Kum Ming
Принадлежит: DexCom, Inc.

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 120-. (canceled)21. An electrochemical continuous glucose sensor configured for implantation in a host , the glucose sensor comprising:an electrode comprising a plurality of electroactive surfaces each configured to measure a signal indicative of a glucose concentration of a host; anda membrane covering at least a portion of the electrode, wherein the membrane comprises an enzyme configured to react with glucose.22. The glucose sensor of claim 21 , wherein each of the electroactive surfaces is shaped like a circle.23. The glucose sensor of claim 21 , wherein each of the electroactive surfaces is shaped like a dot.24. The glucose sensor of claim 21 , wherein the plurality of electroactive surfaces all have a substantially equal area.25. The glucose sensor of claim 21 , wherein the plurality of electroactive surfaces are each spaced apart from at least one adjacent electroactive surface by a substantially equal distance.26. The glucose sensor of claim 21 , wherein the plurality of electroactive surfaces are spaced along a substantial length of an in vivo portion of the glucose sensor.27. The glucose sensor of claim 21 , wherein the membrane comprises a layer configured to control a diffusion of glucose therethrough claim 21 , wherein the layer comprises polyurethane.28. The glucose sensor of claim 21 , wherein the glucose sensor has a planar shape.29. The glucose sensor of claim 21 , wherein the plurality of electroactive surfaces comprise at more than two electroactive surfaces.30. The glucose sensor of claim 21 , wherein the plurality of electroactive surfaces comprise at more than three electroactive surfaces.31. The glucose ...

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Номер записи: 98
08-05-2014 дата публикации

ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE

Номер: US20140128704A1
Автор: Boock Robert J., Brister Mark C., Brunner Seth R., Chee Arthur, Markovic Dubravka, Nguyen Lisa, Nicholas Melissa A., Petisce James R., Pryor Jack, Rixman Monica A., Simpson Peter C., Wightlin Matthew D., Woo Kum Ming
Принадлежит: DexCom, Inc.

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted. 120-. (canceled)21. An electrochemical continuous glucose sensor configured for implantation in a host , the glucose sensor comprising:an electrode configured to measure a signal indicative of a glucose concentration of a host; anda membrane covering at least a portion of the electrode, wherein the membrane comprises a first domain configured to reduce passage of an interfering species therethrough and a second domain comprising an enzyme configured to react with glucose, wherein the first domain is configured to trap interfering species having a molecular weight equal to or greater than a molecular weight of acetaminophen and configured to prevent the interfering species from reaching the electrode, wherein the first domain is positioned between the second domain and the electrode.22. The glucose sensor of claim 21 , wherein the molecular weight is about 151 Daltons.23. The glucose sensor of claim 21 , wherein the interfering species has an oxidation potential that substantially overlaps with an oxidation potential of a measured species indicative of the concentration of the analyte.24. The glucose sensor of claim 23 , wherein the measured species is a product of an enzymatic reaction between glucose and an enzyme and is measured by the electrode.25. The glucose sensor of claim 21 , wherein the glucose sensor has a sensitivity to glucose of from about 25 pA/mg/dL to about 500 pA/mg/dL.26. The glucose sensor of claim 21 , wherein the membrane further comprises a third domain configured to reduce a flux of glucose therethough.27. The glucose sensor of claim 26 , wherein the third domain comprises a product of a reaction of an ...

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Номер записи: 99
03-03-2022 дата публикации

SYSTEM AND METHOD FOR EDUCATING USERS, INCLUDING RESPONDING TO PATTERNS

Номер: US20220068452A1
Автор: Boock Robert J., DeRenzy David, Dunn Laura J., Johnson Matthew Lawrence, Kamath Apurv Ullas, Koehler Katherine Yerre, Pal Andrew Attila, Price David, Reihman Eli, Simpson Peter C., Wu Mark
Принадлежит:

Provided are systems and methods using which users may learn and become familiar with the effects of various aspects of their lifestyle on their health, e.g., users may learn about how food and/or exercise affects their glucose level and other physiological parameters, as well as overall health. In some cases the user selects a program to try; in other cases, a computing environment embodying the system suggests programs to try, including on the basis of pattern recognition, i.e., by the computing environment determining how a user could improve a detected pattern in some way. In this way, users such as type II diabetics or even users who are only prediabetic or non-diabetic may learn healthy habits to benefit their health.

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Номер записи: 100