Method and system for optimizing web page images

In computer multimedia technology, a system, method and computer program product for optimizing images and transmission of images of a web-page transmitted over the Internet and furthermore, optimizing images of a web page on a network server. The method includes detecting the images in the web page to determine the relationship among the images; in response to the determination of the relationship among the images, combining two or more related images into a combinational image; and updating the web page to replace references to the related images with a reference to the combinational image. By optimizing web page images, the server's work required for handling heavy amount of HTTP requests in transmitting the web page images is decreased and the bandwidth requirement for transmitting the web page images is reduced. The quality of the original image is not lowered. And there is no need to make any change to the operation at the client side.

PROVIDING LOW-LATENCY ERROR CORRECTING CODE CAPABILITY FOR MEMORY

A memory controller provides low-latency error correcting code (ECC) capability for a memory. In some implementations, the controller is configured to receive a memory access command that includes an address and a length associated with data that is to be transferred to or from the memory device, and transfer one or more bytes of data and one or more bytes of ECC information to or from locations of the memory device associated with the address and the length.

Oil-gas separation cylinder, an oil-gas separation device and an oil chromatography

The present invention discloses an oil-gas separation cylinder, an oil-gas separation device and an oil chromatography. The oil-gas separation cylinder comprises an oil-gas separation cylinder body of which axe extends in direction of up and down, a separating block which separates the oil-gas separation cylinder body into an upper cavity and a lower cavity, an oil-gas separation cylinder piston movably installed in the lower cavity, an oil inlet passage and an oil outlet passage, and an oil-gas separation cylinder vent arranged at upper end of the upper cavity, wherein both of the oil inlet passage and the oil outlet passage are communicated with the upper cavity, wherein the separating block is provided with a guiding hole and a spaying hole used to communicate the upper cavity to the lower cavity, or the separating block is provided with a spaying hole guiding oil used to communicate the upper cavity to the lower cavity. By motion of an oil-gas separation cylinder piston, oil is spayed ...

Scramble and descramble hardware implementation method based on data bit width expansion

A scramble and descramble hardware implementation method based on data bit width expansion. After expansion, redundant terms are eliminated, and scramble/descramble operation results within the current operation cycle and the value of the shift register after shifting are calculated at once. The present method exhibits advantageous effects with respect to the scramble and descramble polynomial defined by USB3.1 and PCI-Express3.0 protocols, and can obtain a relatively small hardware delay, so that the system can work at a higher frequency.

System and methods for determining structure stiffness

Systems and methods for determining the stiffness of a structure based on vertical track modulus. Vertical deflection data is collected along a particular section of a structure, such as a railroad track. A first set of vertical modulus is determined, based in part, on the collected vertical deflection data. At a second time, vertical deflection data is again collected along the particular section of the structure to be used in determining a second set of vertical modulus. At least the first and second sets of vertical modulus are analyzed to determine a mathematical algorithm that facilitates developing a trend in the vertical track modulus of the structure and evaluating the stiffness of the structure.

Method, server, client and system for controlling download and display of web pages

A method for controlling display of a web page on the client, the contents in said web page being assigned different priorities, includes sending an access request for the web page from the client to the server; in response to said access request, the server sending controllers for implementing prioritization of said contents in the web page to the client, and the controllers retrieving the web page contents the server according to the priority order thereof for display. With the system and method, it is possible to prioritize different contents in a web page and to ensure contents with higher priority are downloaded and displayed earlier than those with lower priority, and thereby avoiding the disadvantage of multi-thread parallel download in the prior art.

Method and apparatus for optically measuring absolute displacement

A method and apparatus using two sets of polarized light detection systems are disclosed for optically measuring absolute displacement. In the first detection system a step motor is controlled to drive an analyzer to trace synchronously the displacement being measured by comparison of the magnitude of the intensity of two orthogonal light beams and then the number of control pulses from the step motor becomes a value of the displacement measured; and by comparison with the magnitude the intensity of a plurality of light beams with phase difference from a plurality of light paths in the second polarized light detection system the section of system operation is ascertain and consequently the absolute displacement is detected and measured.

Correlating out interactions and profiling the same

A method and system for correlating out interactions, which occur due to one or a set of specific events, of an application, which is deployed in multiple adjacent tiers in an actual environment is described. First, a simulation environment corresponding to the actual environment is created. Then, specific events are led to the actual environment and the simulation environment. A pattern(s) of interactions, which are related with the specific events, between adjacent tiers in the simulation environment and a large number of interactions between adjacent tiers in the actual environment are obtained. Afterwards, interactions, which are related with the specific events, between adjacent tiers among the obtained interactions between adjacent tiers in the actual environment are correlated using a template of the obtained pattern(s) of interactions, which are related with the specific events, between adjacent tiers in the simulation environment as a template.

Customizable virtual disk allocation for big data workload

An example method to allocate a virtual disk for a virtual machine in a virtualized computing system includes allocating a plurality of virtual machine disk file (VMDK) candidates in a virtual machine file system (VMFS) volume, selecting a subset of VMDK candidates from the plurality of VMDK candidates for having performance scores indicative of higher I/O throughputs associated with the one or more physical hard disks than rest of the plurality of VMDK candidates, and configuring the virtual disk based on the subset of the VMDK candidates. The VMFS volume is supported by one or more physical hard disks in a storage system in the virtualized computing system.

Vertical track modulus trending

Systems and methods for determining a trend in vertical track modulus are disclosed in accordance with embodiments of the present invention. Vertical deflection data is collected along a particular section of railroad track. A first set of vertical track modulus is determined, based in part, on the collected vertical deflection data. At a second time, vertical deflection data is again collected along the particular section of railroad track to be used in determining a second set of vertical track modulus. At least the first and second sets of vertical track modulus are analyzed to determine a mathematical algorithm that facilitates developing a trend in the vertical track modulus of the railroad track.

Variable length arbitration

In one embodiment, a method determines a plurality of categories for requests for a shared resource being shared by a plurality of entities. A request for the resource is received from an entity in the plurality of entities. The method determines a category in the plurality of categories for the received request. If the received request is determined to be in a first category, the method dispatches the received request to a first arbitration scheme configured to determine an arbitration decision in a first time cycle. If the received request is determined to be in a second category, the method dispatches the received request to a second arbitration scheme configured to determine an arbitration decision in a second time cycle of a different length from the first time cycle.

APPARATUS, SYSTEM, AND METHOD FOR ARCHIVING SMALL OBJECTS TO IMPROVE THE LOADING TIME OF A WEB PAGE

An apparatus, system, and method are disclosed for improving the loading time of a web page. The present invention includes selecting archivable objects in a web page for inclusion in an archive file, the web page referencing at least one archivable object and generating the archive file from the selected archivable objects. A web page is generated, the web page configured to display in a script enabled web browser, wherein the web page comprises executable code configured to retrieve the archive file, executable code configured to unpackage the archivable objects from the archive file, and executable code configured to render the web page in a web browser using the unpackaged archivable objects from the archive file. Beneficially, the apparatus, system, and method improve the load time for web pages.

USB device IP infringement identification method and terminal based on USB protocol

A USB protocol-based IP infringement identification method for USB devices, including the following steps: S1, connecting an infringement identification device at a peer side of the USB host to be tested; S2, the USB host to be tested entering compliance mode; S3, the infringement identification device sending an X.LFPS file to the USB host to be tested; S4, upon the USB host to be tested receiving the X.LFPS file, the USB host to be tested sending IP copyright information to the infringement identification device; S5, determining whether the USB host to be tested infringes the IP. The infringement identification of the USB device to be tested is performed by using the compliance mode specified in the USB protocol, which is more stable, reliable and can also save costs.

Apparatus, system, and method for archiving small objects to improve the loading time of a web page

An apparatus, system, and method are disclosed for improving the loading time of a web page. The present invention includes selecting archivable objects in a web page for inclusion in an archive file, the web page referencing at least one archivable object and generating the archive file from the selected archivable objects. A web page is generated, the web page configured to display in a script enabled web browser, wherein the web page comprises executable code configured to retrieve the archive file, executable code configured to unpackage the archivable objects from the archive file, and executable code configured to render the web page in a web browser using the unpackaged archivable objects from the archive file. Beneficially, the apparatus, system, and method improve the load time for web pages.

Projector having mechanism for reminding filter replacement

A projector having a mechanism for alerting the need of filter replacement is provided. The projector comprises a housing, a filter, a first sensor, and a device. The first sensor is arranged inside the housing for measuring the temperature therein to obtain a first measurement value. When the first measurement value is greater than a predetermined value, the device transmits a signal for alerting a user to replace the filter.

Non-spectral computed tomography (CT) scanner configured to generate spectral volumetric image data

A non-spectral computed tomography scanner (102) includes a radiation source (112) configured to emit x-ray radiation, a detector array (114) configured to detect x-ray radiation and generate non-spectral data, and a memory (134) configured to store a spectral image module (130) that includes computer executable instructions including a neural network trained to produce spectral volumetric image data. The neural network is trained with training spectral volumetric image data and training non-spectral data. The non-spectral computed tomography scanner further includes a processor (126) configured to process the non-spectral data with the trained neural network to produce spectral volumetric image data.

Automatic detecting system and method for audio circuit and keyboard quality of mobile phone

The invention discloses an automatic detecting system and method for an audio circuit and keyboard quality of a mobile phone. The detecting system is composed of a double-layer turnplate with an upper layer and a lower layer and a pneumatic keypad driving device, wherein the upper layer turnplate is a fixed device; the lower layer turnplate is a rotary device; the upper layer turnplate is divided into at least six sectors and each sector is responsible for completing a mobile phone detection station, namely, an idle station I for putting and taking out the mobile phone, a starting-up station II, a model selecting station III, a call testing station IV, an earphone testing station V and a keypad testing station VI; a mobile phone seat is arranged on the lower layer turnplate, corresponding to the position of each sector of the upper turnplate. The detecting method comprises the following six steps: the mobile phone is placed and is started; the mobile phone gets into a detection model; a ...

METHOD, SERVER, CLIENT AND SYSTEM FOR CONTROLLING DOWNLOAD AND DISPLAY OF WEB PAGES

A method for controlling display of a web page on the client, the contents in said web page being assigned different priorities, includes sending an access request for the web page from the client to the server; in response to said access request, the server sending controllers for implementing prioritization of said contents in the web page to the client, and the controllers retrieving the web page contents the server according to the priority order thereof for display. With the system and method, it is possible to prioritize different contents in a web page and to ensure contents with higher priority are downloaded and displayed earlier than those with lower priority, and thereby avoiding the disadvantage of multi-thread parallel download in the prior art.

On-node DHCP implementation for virtual machines

A DHCP server implementation includes transmission of a DHCP packet from a virtual machine executing on a server node to a node agent executing on the server node, generation, by the node agent, of a DHCP response packet based on the DHCP packet and on DHCP information previously stored in a local memory of the server node, and transmission of the DHCP response packet from the node agent to the virtual machine. Neither the DHCP packet transmitted by the virtual machine nor the DHCP response packet are transmitted out of the server node.

Buffered audio system with synchronizing bus controller

An audio system includes an audio client device and an access point. The audio client device includes a buffer, a clock generator, a bus controller, a bus receiver, and a control module. The buffer is configured to receive a stream of samples of audio data. The clock generator is configured to generate a first clock signal. The bus controller is configured to read samples from the buffer for transmission across a bus using the first clock signal. The bus receiver is configured to receive samples from the bus controller and output a sampling clock along with each sample. The control module is configured to analyze activity of the buffer and modify operation of the bus controller to synchronize the sampling clock with a remote sampling clock. The access point includes an audio content module, a decoding module, and a network interface that wirelessly transmits the stream of samples.

System and Methods for Determining Structure Stiffness

Systems and methods for determining the stiffness of a structure based on vertical track modulus are disclosed in accordance with embodiments of the present invention. Vertical deflection data is collected along a particular section of a structure, such as a railroad track. A first set of vertical modulus is determined, based in part, on the collected vertical deflection data. At a second time, vertical deflection data is again collected along the particular section of the structure to be used in determining a second set of vertical modulus. At least the first and second sets of vertical modulus are analyzed to determine a mathematical algorithm that facilitates developing a trend in the vertical track modulus of the structure and evaluating the stiffness of the structure.

Providing error correcting code (ECC) capability for memory

A method includes, in at least one aspect, designating a first region of a memory device for storing data of a first type and first error correcting code (ECC) data; designating a second region for storing data of a second type and second ECC data; receiving the data of the first type; generating the first ECC data for the data of the first type using a first ECC associated with a first ECC protection level; storing the data of the first type and the first ECC data in adjacent locations of the first region; receiving the data of the second type; generating the second ECC data for the data of the second type using a second ECC associated with a second ECC protection level; and storing the data of the second type and the second ECC data in the second region.

Non-spectral computed tomography (CT) scanner configured to generate spectral volumetric image data

A non-spectral computed tomography scanner includes a radiation source configured to emit x-ray radiation, a detector array configured to detect x-ray radiation and generate non-spectral data, and a memory configured to store a spectral image module that includes computer executable instructions including a neural network trained to produce spectral volumetric image data. The neural network is trained with training spectral volumetric image data and training non-spectral data. The non-spectral computed tomography scanner further includes a processor configured to process the non-spectral data with the trained neural network to produce spectral volumetric image data.

Method and system for dynamic composing and creating 3D virtual devices

The present invention describes a method and system for governing a physical device or application service in a real world through a virtual device in a virtual world. The physical device or application service registers at least one virtual adaptor of the physical device or application service to a virtual device broker. A user creates or composes the virtual device with the at least one virtual adaptor in the virtual device broker. The user commands to the virtual device through a user interface of the virtual device. The at least one virtual adaptor in the virtual device translates the command to a controlling signal to the physical device or application service. The controlling signal operates the physical device or application service according to the command to the virtual device.

Method and apparatus for recording events in virtual worlds

A method and an apparatus for recording an event in a virtual world. The method includes acquiring camera view regions of avatars joining the event; identifying one or more key avatars and/or key objects based on information about the targets in the camera view regions of the avatars; setting one or more recorders for the identified one or more key avatars and/or key objects for recording the event such that the one or more key avatars and/or key objects are located in the camera view regions of the one or more recorders. The apparatus includes devices configured to perform the steps of the method.

On-node DHCP implementation for virtual machines

A DHCP server implementation includes transmission of a DHCP packet from a virtual machine executing on a server node to a node agent executing on the server node, generation, by the node agent, of a DHCP response packet based on the DHCP packet and on DHCP information previously stored in a local memory of the server node, and transmission of the DHCP response packet from the node agent to the virtual machine. Neither the DHCP packet transmitted by the virtual machine nor the DHCP response packet are transmitted out of the server node.

Generating error correcting code (ECC) data using an ECC corresponding to an identified ECC protection level

A memory controller provides error correcting code (ECC) capability for a memory. In some implementations, the controller is configured to identify an ECC protection level from a plurality of ECC protection levels for data that is to be stored in the memory device, generate ECC data for the data that is to be stored in the memory device using an ECC corresponding to the identified ECC protection level, store the generated ECC data in the cache, and store the data in the memory device.

SYSTEM AND METHOD FOR OBJECT SEARCHING IN VIRTUAL WORLDS

A system and method enabling the search for a three-dimensional virtual world object across the universe of virtual worlds by utilizing a two-step search process to first identify the object and second, to actively locate and generate a URI to all presently manifest instances of that object.

Method and apparatus for optically measuring absolute displacement

A method and apparatus using two sets of polarized light detection systems are disclosed for optically measuring absolute displacement. In the first detection system a step motor is controlled to drive an analyzer to trace synchronously the displacement being measured by comparison of the magnitude of the intensity of two orthogonal light beams and then the number of control pulses from the step motor becomes a value of the displacement measured; and by comparison with the magnitude the intensity of a plurality of light beams with phase difference from a plurality of light paths in the second polarized light detection system the section of system operation is ascertain and consequently the absolute displacement is detected and measured.

Resolving a convex optimization problem to optimize network traffic in a distributed system

Techniques are disclosed herein for managing network bandwidth in a distributed system having multiple endpoints that upload data to a central server or server cluster. One embodiment provides a computer-implemented method that includes receiving a logical topology of the network that is determined based on network measurements. The method further includes resolving a convex optimization problem over the logical topology to determine a bandwidth allocation scheme for the endpoints uploading data. In addition, the method includes controlling bandwidth consumption by the endpoints based on the determined bandwidth allocation scheme.

Systems And Methods For DQS Gating

Systems and methods for timing read operations with a memory device are provided. A timing signal is received from the memory device at a gating circuit. The timing signal is passed through as a filtered timing signal during a gating window. The gating window is configured to open the gating window based on a control signal and to close the gating window based on a falling edge of the timing signal. The falling edge is determined based on a counter that is triggered to begin counting by the control signal. The control signal is generated at a timing control circuit after receiving a read request from a memory controller. The timing control circuit is configured to delay generation of the control signal to cause the gating window to open during a preamble portion of the timing signal.

SYSTEM AND METHOD FOR OBJECT SEARCHING IN VIRTUAL WORLDS

A system and method enabling the search for a three-dimensional virtual world object across the universe of virtual worlds by utilizing a two-step search process to first identify the object and second, to actively locate and generate a URI to all presently manifest instances of that object.

System and method for object searching in virtual worlds

A system and method enabling the search for a three-dimensional virtual world object across the universe of virtual worlds by utilizing a two-step search process to first identify the object and second, to actively locate and generate a URI to all presently manifest instances of that object.

Vertical track modulus trending

Systems and methods for determining a trend in vertical track modulus are described. Vertical deflection data is collected along a particular section of railroad track. A first set of vertical track modulus is determined, based in part, on the collected vertical deflection data. At a second time, vertical deflection data is again collected along the particular section of railroad track to be used in determining a second set of vertical track modulus. At least the first and second sets of vertical track modulus are analyzed to determine a mathematical algorithm that facilitates developing a trend in the vertical track modulus of the railroad track.

Method and System for Providing Scene Data of Virtual World

Methods and systems for providing scene data of a virtual world. One method includes the following steps: receiving a request for downloading the scene data from a content requesting party, where the request includes (i) information on an object group in the scene data and (ii) Level of Detail (LoD) information on an object in the object group, packing LoD content of the object in the object group based on the information on the object group and the LoD information on the object, and transmitting the packed LoD content corresponding to the object group to the content requesting party.

Buffered audio system with synchronizing bus controller

A method includes receiving samples of audio data and storing the samples of audio data in a buffer. Each of the samples of audio data includes a plurality of bits. The method also includes transmitting each of the plurality of bits, of each of the samples of audio data retrieved from the buffer, across a single-bit bus; and subsequent to transmitting each of the samples, transmitting a selected number of dummy bits across the single-bit bus. The selected number is greater than one. The method further includes analyzing activity of the buffer and, based on the activity of the buffer, dynamically adjusting the selected number. The method also includes acquiring the samples of audio data transmitted across the single-bit bus and ignoring the dummy bits. The method further includes generating analog signals in response to the samples of audio data acquired across the single-bit bus.

Monitoring multiple remote desktops on a wireless device

Methods and systems configured to facilitate monitoring of multiple remote desktops in a user interface of a wireless device are provided. One example method includes maintaining image data representing a prior state of graphical displays of a plurality of graphical user interfaces associated with the remote desktops, in response to receiving a first request specifying first display information from the wireless device, preparing first update information for a first scaled image corresponding to content of a first graphical display, wherein the first scaled image contains image data defining a lower resolution version of a current state of a first graphical display out of the graphical displays, the scaled version is being sized according to the first display information received from the wireless device, and transmitting the prepared first update information to the wireless device to be displayed in the user interface.

Packet capture via packet tagging

Techniques are disclosed for capturing network traffic in a virtualized computing environment. A packet to be captured in the virtualized environment is identified. The packet is tagged using a pattern of one or more bits in a header of the packet. The pattern indicates that the packet is to be traced. The pattern is propagated to an outer layer during encapsulation of the packet. A header of the encapsulated packet includes the pattern of one or more bits. At least one network device is caused to mirror identified packets based on the reserved bit.

METHOD AND SYSTEM FOR DYNAMIC COMPOSING AND CREATING 3D VIRTUAL DEVICES

The present invention describes a method and system for governing a physical device or application service in a real world through a virtual device in a virtual world. The physical device or application service registers at least one virtual adaptor of the physical device or application service to a virtual device broker. A user creates or composes the virtual device with the at least one virtual adaptor in the virtual device broker. The user commands to the virtual device through a user interface of the virtual device. The at least one virtual adaptor in the virtual device translates the command to a controlling signal to the physical device or application service. The controlling signal operates the physical device or application service according to the command to the virtual device.

Reverse breadth-first search method for optimizing network traffic in a distributed system with a point of convergence

Techniques are disclosed herein for managing network bandwidth in a distributed system having multiple endpoints that upload data to a central server or server cluster. One embodiment provides a computer-implemented method that includes receiving a logical topology of the network that is determined based on network measurements. The method further includes generating a tree having links of the logical network topology as nodes, and allocating bandwidth during a traversal of the tree to obtain a bandwidth allocation scheme for the endpoints uploading data. In addition, the method includes controlling bandwidth consumption by the endpoints based on the determined bandwidth allocation scheme.

Variable Length Arbitration

In one embodiment, a method determines a plurality of categories for requests for a shared resource being shared by a plurality of entities. A request for the resource is received from an entity in the plurality of entities. The method determines a category in the plurality of categories for the received request. If the received request is determined to be in a first category, the method dispatches the received request to a first arbitration scheme configured to determine an arbitration decision in a first time cycle. If the received request is determined to be in a second category, the method dispatches the received request to a second arbitration scheme configured to determine an arbitration decision in a second time cycle of a different length from the first time cycle.

METHOD AND APPARATUS FOR RECORDING EVENTS IN VIRTUAL WORLDS

A method and an apparatus for recording an event in a virtual world. The method includes acquiring camera view regions of avatars joining the event; identifying one or more key avatars and/or key objects based on information about the targets in the camera view regions of the avatars; setting one or more recorders for the identified one or more key avatars and/or key objects for recording the event such that the one or more key avatars and/or key objects are located in the camera view regions of the one or more recorders. The apparatus includes devices configured to perform the steps of the method.

MONITORING METHOD AND SYSTEM OF ARRESTER APPLIED TO SMART SUBSTATION

The present invention relates to a monitoring method and system of arrester applied to smart substation. The monitoring method of arrester applied to smart substation includes following steps: 1) getting original sample value of the arrester leakage current, 2) getting resample values of the original sample values of leakage current and SV voltage signals, 3) getting the amplitude and the phase values of the resample values of the leakage current and the SV voltage signals by Fourier transforming, 4) calculating angles between the resample values of the leakage current and the SV voltage signals according to the phase values of the resample values of the leakage current and the SV voltage signals, and calculating value of resistive current with the method of fundamental wave projection, 5) getting value of resistive current after medium filtered by medium filtering the value of resistive current, making a comparison of the value of resistive current after medium filtered and setting threshold ...

Method and system for optimizing network traffic in a distributed system with a point of convergence

Techniques are disclosed herein for managing network bandwidth in a distributed system having multiple endpoints that upload data to a central server or server cluster. One embodiment provides a computer-implemented method that includes collecting network measurements from traffic flows in a network over which the endpoints upload the data to the central server or server cluster. The method further includes determining a logical topology of the network based on the network measurements, and solving an optimization problem to determine a bandwidth allocation scheme for the endpoints uploading data, wherein capacity of links in the logical topology are constraints in the optimization problem. In addition, the method includes controlling bandwidth consumption by the endpoints based on the determined bandwidth allocation scheme.

System having a first device and second device in which the main power management module is configured to selectively supply a power and clock signal to change the power state of each device independently of the other device

A system includes a first device, a second device, and a main power management module. The first device is configured to communicate with a system bus. The second device is configured to communicate with the system bus. The second device includes a device power management module configured to manage power states of the second device. The main power management module is configured to manage power consumption of the second device independently of the first device by selectively supplying power and clock signals to the second device based on the power states of the second device. The main power management module and the device power management module each comprise a power handshake interface. The main power management module communicates with the device power management module via a power management bus using the power handshake interface.

VERTICAL TRACK MODULUS TRENDING

Systems and methods for determining a trend in vertical track modulus are disclosed in accordance with embodiments of the present invention. Vertical deflection data is collected along a particular section of railroad track. A first set of vertical track modulus is determined, based in part, on the collected vertical deflection data. At a second time, vertical deflection data is again collected along the particular section of railroad track to be used in determining a second set of vertical track modulus. At least the first and second sets of vertical track modulus are analyzed to determine a mathematical algorithm that facilitates developing a trend in the vertical track modulus of the railroad track.

Multi-mode USB-satellite digital transceiver port

An interface includes a port and a port control module. The port control module detects whether a remote device communicating with the port is one of a Universal Serial Bus (USB) device and a satellite digital transceiver (DT) device. The port control module selectively generates one of a USB configure signal and a satellite DT configure signal. A USB control module selectively configures the interface to communicate with the USB device when the USB configure signal is received. A satellite control module selectively configures the interface to communicate with the satellite DT device when the satellite DT configure signal is received.

METHOD AND SYSTEM FOR OPTIMIZING WEB PAGE IMAGES

In computer multimedia technology, a system, method and computer program product for optimizing images and transmission of images of a web-page transmitted over the Internet and furthermore, optimizing images of a web page on a network server. The method includes detecting the images in the web page to determine the relationship among the images; in response to the determination of the relationship among the images, combining two or more related images into a combinational image; and updating the web page to replace references to the related images with a reference to the combinational image. By optimizing web page images, the server's work required for handling heavy amount of HTTP requests in transmitting the web page images is decreased and the bandwidth requirement for transmitting the web page images is reduced. The quality of the original image is not lowered. And there is no need to make any change to the operation at the client side.

Self governing power management architecture that allows independent management of devices based on clock signals and a plurality of control signals written to control registers

A first power management module includes a power management interface to communicate with a power management bus and manages power states of a first device communicating with a system bus. The power management interface includes a first interface to communicate a first control signal to transition the first device from a first power state to a second power state, a second interface to communicate a second control signal to turn on or off a power supply to the first device, and a third interface to communicate a third control signal to turn on or off a clock of the first device. A second power management module manages power consumption of the first device, independently of a second device communicating with the system bus, based on the power states of the first device using one or more of the first control signal, the second control signal, and the third control signal.

UNIVERSAL SERIAL BUS (USB) STORAGE DEVICE AND ACCESS CONTROL METHOD THEREOF

The invention provides a USB storage device and an access control method thereof. An access control module is provided on the USB storage device. The storage space is divided into at least one data storage entity. Each user's access right to each data storage entity is set and stored in the USB storage device as an access control list. The process between the USB storage device's being connected with a USB host and its being disconnected from the USB host is one session. When a session is established, the user provides authentication information for the USB device to authenticate him/her, and saves the user information used in the current session. In the current session, when the host of the user issues an access request for the data storage entity on the USB storage device, the access control module queries the access right list based on the user information in the current session to determine whether the user has an access right to the requested data storage entity. When the user does ...

METHOD AND USE FOR GENOMIC SELECTION OF NON-FAMILY AND LOW-HERITABILITY VARIETY

A method and system for genomic selection of a non-family and low-heritability variety are provided. The method includes: evaluating a single nucleotide polymorphisms (SNPs) effect size based on a non-equivalent condition of SNPs by correcting a correlation relationship between the SNPs; and breeding the non-family and low-heritability variety based on the SNPs effect size. In the present disclosure, the method for evaluating the SNPs effect size can be used for breeding the non-family and low-heritability variety.

Method and apparatus for processing user's files

A method and an apparatus for processing user's files, by categorizing user's files and for generating a personal working set. Categorizing user's files is done by capturing history information about the user's operations on files; clustering the files operated by the user to generate one or more categories based on the captured history information and at least one predefined file relationship. User's history of operations on files as well as file relationships implied during user's operation can be reflected by the generated categories.

OIL-GAS SEPARATION CYLINDER, AN OIL-GAS SEPARATION DEVICE AND AN OIL CHROMATOGRAPHY

The present invention discloses an oil-gas separation cylinder, an oil-gas separation device and an oil chromatography. The oil-gas separation cylinder comprises an oil-gas separation cylinder body of which axe extends in direction of up and down, a separating block which separates the oil-gas separation cylinder body into an upper cavity and a lower cavity, an oil-gas separation cylinder piston movably installed in the lower cavity, an oil inlet passage and an oil outlet passage, and an oil-gas separation cylinder vent arranged at upper end of the upper cavity, wherein both of the oil inlet passage and the oil outlet passage are communicated with the upper cavity, wherein the separating block is provided with a guiding hole and a spaying hole used to communicate the upper cavity to the lower cavity, or the separating block is provided with a spaying hole guiding oil used to communicate the upper cavity to the lower cavity. By motion of an oil-gas separation cylinder piston, oil is spayed ...

Systems and methods for DQS gating

Systems and methods for timing read operations with a memory device are provided. A timing signal is received from the memory device at a gating circuit. The timing signal is passed through as a filtered timing signal during a gating window. The gating window is configured to open the gating window based on a control signal and to close the gating window based on a falling edge of the timing signal. The falling edge is determined based on a counter that is triggered to begin counting by the control signal. The control signal is generated at a timing control circuit after receiving a read request from a memory controller. The timing control circuit is configured to delay generation of the control signal to cause the gating window to open during a preamble portion of the timing signal.

System and method for object searching in virtual worlds

A system and method enabling the search for a three-dimensional virtual world object across the universe of virtual worlds by utilizing a two-step search process to first identify the object and second, to actively locate and generate a URI to all presently manifest instances of that object.

Pitching Machine Having Angle and Speed Adjustment Function

A pitching machine includes a stand unit, a direction adjusting device swivelably mounted on the stand unit, a base unit pivotally mounted on the direction adjusting device, two pitch adjusting devices mounted on the base unit, and an angle adjusting device pivotally mounted between the base unit and the direction adjusting device. The base unit includes a base frame, two side brackets, two screwed sockets, two rotation wheels, two drive motors, a guide track, and a push member. Thus, the inclined angle of each of the rotation wheels can be adjusted individually by each of the pitch adjusting devices so that the rotation wheels can be adapted to have different inclined angles. In addition, the angle adjusting device can move the base frame relative to the support arm to change the inclined angle of the base frame.

Pedal power generating device

A pedal power generating device includes a base having two supporting arms upwardly extending therefrom. The base has a gearbox mounted thereon. A pedal assembly is mounted between the two supporting arms. The pedal assembly has a pedal, a supporter extending from the pedal, a connecting rod assembled with the supporter and connected to the gearbox, and a twist spring mounted between the pedal and the two supporting arms. A transmitting assembly is mounted in the gearbox. The transmitting assembly includes a driver, a first gear train engaged with the driver, a second gear train engaged with the first gear train, and a steering gear set simultaneously engaging with the first gear train and the second gear train. A generator is mounted adjacent to the gearbox, and the generator has a rotor engaged with the second gear train.

HUMAN MONOCLONAL ANTIBODIES TO PROTEIN TYROSINE KINASE 7 (PTK7) AND METHODS FOR USING ANTI-PTK7 ANTIBODIES

The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PTK7 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PTK7, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PTK7 antibodies. 1. An isolated nucleic acid molecule encoding an antibody or antigen-binding portion thereof , wherein the antibody:a) specifically binds to human PTK7; andb) binds to a Wilms' tumor cell line (ATCC Acc No. CRL-1441).2. The nucleic acid of claim 1 , wherein the antibody comprises a heavy chain variable region encoded by a nucleic acid sequence selected from the group consisting of: SEQ ID NOs: 41 claim 1 , 42 claim 1 , 43 claim 1 , and 44.3. The nucleic acid of claim 1 , wherein the antibody comprises a light chain variable region encoded by a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 45 claim 1 , 46 claim 1 , 47 claim 1 , 48 claim 1 , 49 claim 1 , and 50.4. The nucleic acid molecule of claim 1 , wherein the antibody comprises heavy and light chain variable regions encoded by nucleic acid sequences selected from the group consisting of SEQ ID NO: 41 and SEQ ID NO: 45; SEQ ID NO: 41 and SEQ ID NO: 46; SEQ ID NO: 42 and SEQ ID NO: 47; SEQ ID NO: 43 and SEQ ID NO: 48; SEQ ID NO: 43 and SEQ ID NO: 49; and SEQ ID NO: 44 and SEQ ID NO: 50 claim 1 , respectively.5. An expression vector comprising the nucleic acid molecule of .6. A host cell comprising the expression vector of .7. A method for preparing an anti-PTK7 antibody which comprises expressing the antibody in the host cell of and isolating the antibody from ...

SWITCH LEVEL CIRCUIT WITH DEAD TIME SELF-ADAPTING CONTROL

A switch level circuit () with dead time self-adapting control, which minimizes the switching loss in a switching power supply converter with synchronous rectification by changing a dead time between a high-side control transistor () and a low-side synchronous rectifying transistor (). The switch level circuit () includes the high-side control transistor () and the low-side synchronous rectifying transistor () which are controlled to be on and off by external control signals, and a waveform with a given duty cycle is outputted at a node (LX) between the two transistors. The switch level circuit () also includes a control module for adjusting the dead time. The control module comprises a sampling circuit () for detecting the current dead time at the node (LX), an adjusting circuit () for buffering and converting the sampling voltage sampled by the sampling circuit (), and a controlled delay unit () equipped with an external control input terminal, wherein the controlled delay unit () delays an external control signal and outputs the delayed signal to a controlled terminal of the low-side synchronous rectifying transistor () as a control signal. The switch level circuit () has simple structure, better performance and wide application range. 1101110111011101011111011141310111617161511. A switch level circuit with self-adapting dead time control capability which includes a high-side control transistor () and a low-side synchronous rectifying transistor () , wherein , the source end of the high-side control transistor () is connected to the input voltage , and the source end of the low-side synchronous rectifying transistor () is grounded , the drain end of the high-side control transistor () is connected to the drain end of the low-side synchronous rectifying transistor () to form a switching node (LX) , the gate end of the high-side control transistor () , which is used as a controlled end of the high-side control transistor () , is used for the input of a first ...

Switching power supply with quick transient response

A switching power supply with a quick transient response is provided. A hysteretic control loop which comprises a hysteretic controller ( 117 ) and a control signal gate ( 116 ) is added to the original PWM control loop of the switching power supply. The hysteretic controller ( 117 ) is used to detect an output voltage (Vout) of the switching power supply and compare the output voltage (Vout) of the switching power supply with a reference voltage (Vref). When a load current (Iout) of the switching power supply is suddenly changed, the output voltage (Vout) of the switching power supply fluctuates. If the output voltage (Vout) of the switching power supply is in a setting range of the hysteretic voltage, output terminals (SELp, SELn) of the hysteretic controller ( 117 ) are in a low potential, and the control signal gate ( 116 ) selects output signals (Qp 1 , Qn 1 ) from a PWM controller ( 101 ) as input signals of a gate signal drive circuit ( 106 ). If the fluctuation of the output voltage (Vout) of the switching power supply exceeds the setting range of the hysteretic voltage, an output terminal (SELp, SELn) of the hysteretic controller ( 117 ) outputs a high potential, and the control signal gate ( 116 ) selects output signals (Qp 2 , Qn 2 ) of the hysteretic controller ( 117 ) as input signals of the gate signal drive circuit ( 106 ), so the operation of switching tubes ( 111, 112 ) at the power lever ( 102 ) of the switching power supply is controlled to stabilize the output voltage (Vout).

SILICON ON INSULATOR INTEGRATED HIGH-CURRENT N TYPE COMBINED SEMICONDUCTOR DEVICE

A silicon on insulator integrated high-current N type combined semiconductor device, which can improve the current density, comprises a P type substrate and a buried oxide layer arranged thereon. A P type epitaxial layer divided into a region I and a region II is arranged on the buried oxide layer. The region I comprises an N type drift region, a P type deep well, an N type buffer well, a P type drain region, an N type source region and a P type body contact region; a field oxide layer and agate oxide layer are arranged on a silicon surface, and a polysilicon lattice is arranged on the gate oxide layer. The region II comprises an N type triode drift region, a P type deep well, an N type triode buffer well, a P type emitting region, an N type base region, an N type source region and a P type body contact region; a field oxide layer and a gate oxide layer are arranged on a silicon surface, and a polysilicon lattice is arranged on the gate oxide layer. It is characterized in that the N type base region is wrapped in the N type buffer region, and the drain electrode metal on the P type drain region is connected with the base electrode metal on the N type base region by a metal layer. In this invention, the current density of the device has been obviously improved without increasing the device area and reducing other performances of the device. 11211621112161112721112111210110221011022111211127070. A SOI integratable high-current N-type combined semiconductor device , comprising: a P-type silicon substrate (); a buried oxide layer () arranged on the P-type silicon substrate (); characterized in that a P-type deep trench () arranged above the center of the buried oxide layer (); an N-type annular source region () and a P-type body contact region () arranged on the P-type deep trench () , wherein , the N-type annular source region () surrounds outside of the P-type body contact region () , and a piece of source electrode metal () is arranged on the N-type source region () ...

ELECTRONIC DATA EXCHANGE SYSTEM AND METHOD OF EXCHANGING ELECTRONIC DATA

Electronic data exchange system includes a transmitting portable electronic device and a server. The transmitting portable electronic device has an application program. A user of the transmitting portable electronic device utilizes the application program to generate an electronic data transmission control command. The server includes a data base. The data base stores an electronic data album of the user. When the server transmits electronic data of the user to at least one receiving portable electronic device, and transmits electronic data of at least one user of the at least one receiving portable electronic device to the transmitting portable electronic device according to the electronic data transmission control command, the server updates the electronic data album according to the electronic data of the at least one user. 1. An electronic data exchange system , comprising:a transmitting portable electronic device having an electronic data exchange application program, wherein a user of the transmitting portable electronic device utilizes the electronic data exchange application program to generate an electronic data transmission control command; anda server comprising a data base, wherein the data base is used for storing an electronic data album of the user, wherein when the server transmits electronic data of the user to at least one receiving portable electronic device according to the electronic data transmission control command, and transmits electronic data of at least one user of the at least one receiving portable electronic device to the transmitting portable electronic device, the server updates the electronic data album of the user according to the electronic data of the at least one user;wherein the at least one receiving portable electronic device has the electronic data exchange application program, and the electronic data album comprises the electronic data of the user and electronic data of other people.2. The electronic data exchange system of ...

Film affixing apparatus

A film affixing apparatus for affixing a film to a workpiece includes a stand, a film provider, and an affixing device. The stand includes a work platform. The workpiece slides along the work platform under an external force. The film provider is mounted to the stand and dispenses rolls of film. The affixing device is mounted to the stand. The affixing device includes a pressing portion that faces the work platform. The film is unwound and passes over the pressing portion onto the workpiece on the work platform. The pressing portion presses the film onto the workpiece.

Machine for cutting object and sticking film

A machine for cutting off a redundant part of a workpiece and affixing film to a top surface of the workpiece includes a stand, a cutting device, and an affixing device. The stand has a work platform. The workpieces slide on the work platform. The cutting device includes a first blade. The film provider dispenses the film. The affixing device has a pressing portion facing the work platform. The workpiece slides to the cutting device and the affixing device. The film is unwound and passes over the pressing portion. The cutting device cuts off the redundant parts of the workpiece when the workpiece slides under the cutting device, and the pressing portion presses the film onto the top surface of the workpiece when the workpiece slides under the affixing device.

SYNCHRONOUS RECTIFYING APPARATUS AND CONTROLLING METHOD THEREOF

The present application provides a synchronous rectifying apparatus and a control method thereof, the apparatus comprising: a transformer, a primary circuit, a rectifying circuit, a self-driving circuit, a PWM control circuit and an auxiliary control module including at least one auxiliary control circuit and at least one auxiliary winding, wherein the auxiliary control circuit includes at least one auxiliary switch and is electrically coupled to the Pulse Width Modulation control circuit and the auxiliary winding via the auxiliary switch, and the auxiliary winding is electrically coupled to the transformer; wherein before the transfer switch of the primary circuit is controlled to be turned on by the switching control signal, the auxiliary switch is controlled to be turned on by the auxiliary control signal, and the synchronous rectifier of the rectifying circuit is controlled to be turned off through the self-driving signal. 1. A synchronous rectifying apparatus , comprising:a transformer including a primary winding and a secondary winding;a primary circuit including at least one transfer switch and being electrically coupled to the primary winding;a rectifying circuit including at least one synchronous rectifier and being electrically coupled to the secondary winding;a self-driving circuit electrically coupled to the rectifying circuit and outputting a self-driving signal;a Pulse Width Modulation control circuit electrically coupled to the primary circuit and outputting at least one switching control signal and at least one auxiliary control signal; andan auxiliary control module including at least one auxiliary control circuit and at least one auxiliary winding, wherein the auxiliary control circuit includes at least one auxiliary switch and is electrically coupled to the Pulse Width Modulation control circuit and the auxiliary winding via the auxiliary switch, and the auxiliary winding is electrically coupled to the transformer;wherein before the transfer ...

POWER CONVERSION MODULE

A power conversion module includes a high-voltage side, a low-voltage side, a magnetic element, a high-voltage side circuit, and a low-voltage side circuit. The first end includes a high-voltage positive terminal and a high-voltage negative terminal. The second end includes a low-voltage positive terminal and a low-voltage negative terminal. The magnetic element includes two first windings. The high-voltage side circuit is electrically connected with the high-voltage positive terminal and the high-voltage negative terminal. The low-voltage side circuit is electrically connected with the low-voltage positive terminal and the low-voltage negative terminal. At least one AC loop includes at least one of the first windings, at least one part of the high-voltage side circuit and the low-voltage side circuit. The high-voltage side circuit and the low-voltage side circuit are located at a same side with respect to the magnetic element. 1. A power conversion module , comprising:a first end comprising a high-voltage positive terminal and a high-voltage negative terminal;a second end comprising a low-voltage positive terminal and a low-voltage negative terminal, wherein the low-voltage negative terminal is electrically connected with the high-voltage negative terminal;a magnetic element comprising two first windings;a high-voltage side circuit electrically connected with the high-voltage positive terminal and the high-voltage negative terminal, and electrically connected with the two first windings of the magnetic element; anda low-voltage side circuit electrically connected with the low-voltage positive terminal and the low-voltage negative terminal, and electrically connected with the two first windings of the magnetic element,wherein the power conversion module comprises at least one alternating current (AC) loop defined by at least one of the first windings, at least one part of the high-voltage side circuit, and at least one part of the low-voltage side circuit, wherein ...

ELECTRONIC DEVICE AND PAIRING METHOD THEREOF

An electronic device and a pairing method including following steps are provided. A first touch operation performed on a first touch unit of a first electronic device is detected, and a first azimuth angle of a first pointing direction (defined by the first touch operation) with respect to a reference direction is obtained. The first azimuth angle is compared with a second azimuth angle to obtain an included angle between the first pointing direction and a second pointing direction. When a value obtained by subtracting 180 degrees from an absolute value of the included angle is smaller than a threshold, a pairing relationship is established between the first and second electronic devices. The second azimuth angle is an azimuth angle of the second pointing direction (defined by a second touch operation performed on a second touch unit of the second electronic device) with respect to the reference direction. 1. A pairing method of electronic devices , the pairing method comprising:detecting a first touch operation performed on a first touch unit of a first electronic device and obtaining a first azimuth angle of a first pointing direction with respect to a reference direction, wherein the first pointing direction is defined by the first touch operation; andcomparing the first azimuth angle with a second azimuth angle to obtain an included angle between the first pointing direction and a second pointing direction, and establishing a pairing relationship between the first electronic device and a second electronic device if a value obtained by subtracting 180 degrees from an absolute value of the included angle is smaller than a threshold,wherein the second azimuth angle is an azimuth angle of the second pointing direction with respect to the reference direction, and the second pointing direction is defined by a second touch operation performed on a second touch unit of the second electronic device.2. The pairing method as recited in claim 1 , wherein the step of ...

HETEROJUNCTION SEMICONDUCTOR DEVICE WITH LOW ON-RESISTANCE

A heterojunction semiconductor device with a low on-resistance includes a metal drain electrode, a substrate, and a buffer layer. A current blocking layer arranged in the buffer layer, a gate structure is arranged on the buffer layer, and the gate structure comprises a metal gate electrode, GaN pillars and AlGaN layers, wherein a metal source electrode is arranged above the metal gate electrode; and the current blocking layer comprises multiple levels of current blocking layers, the centers of symmetry of the layers are collinear, and annular inner openings of the current blocking layers at all levels gradually become smaller from top to bottom. The AlGaN layers and the GaN pillars are distributed in a honeycomb above the buffer layer.

HUMAN MONOCLONAL ANTIBODIES TO O8E

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to O8E with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer. 1. A method of treating or preventing a disease characterized by growth of tumor cells expressing O8E , comprising administering to a subject an isolated monoclonal antibody or antigen-binding portion thereof , in an amount effective to treat or prevent the disease , wherein the antibody or antigen binding portion thereof comprises a heavy chain variable region comprising CDR1 , CDR2 , and CDR3 domains; and a light chain variable region comprising CDR1 , CDR2 , and CDR3 domains , wherein the heavy chain variable region and light chain variable region CDR3 domains are selected from the group consisting of (a) a heavy chain variable region CDR3 comprising amino acids having the sequence set forth in SEQ ID NO:21; and a light chain variable region CDR3 comprising amino acids having the sequence set forth in SEQ ID NO:36 and conservative modifications thereof;(b) a heavy chain variable region CDR3 comprising amino acids having the sequence set forth in SEQ ID NO:22; and a light chain variable region CDR3 comprising amino acids having the sequence set forth in SEQ ID NO:37 and conservative modifications thereof;(c) a heavy chain variable region CDR3 comprising amino acids having the sequence set forth in SEQ ID NO:23; and a light chain variable region CDR3 comprising amino acids having the sequence set forth in SEQ ID NO:38 and conservative modifications thereof;(d) a heavy chain variable region CDR3 comprising amino acids having the sequence set forth ...

SIDE SNOWPLOW INCLUDING LAND LEVELER

A side snowplow including a land leveler, comprising: a rear mounted seat (), a hydraulic cylinder I (), a pull rod (), a snow-pushing board (), an oscillating rod (), a hydraulic cylinder II (), and a front mounted seat (). The rear mounted seat () is fixed on a rear portion of a rear rack of the land leveler and connected to the pull rod (); the hydraulic cylinder I () is hingedly connected to the rear mounted seat (), and the pull rod (); and the snow-pushing board () is positioned at a left side or a right side of the land leveler and inclines toward a direction that the land leveler moves, a rear end of the snow-pushing board () being connected to the hinge plate II (), a front end of the snow-pushing board () being connected to the hinge plate III (). 11347101112. A side snowplow including a land leveler , comprising: a rear mounted seat () , a hydraulic cylinder I () , a pull rod () , a snow-pushing board () , an oscillating rod () , a hydraulic cylinder II () , and a front mounted seat () , wherein:{'b': 1', '1', '2', '9, 'the rear mounted seat () is fixed on a rear portion of a rear rack of the land leveler, the rear mounted seat () being hingedly connected to a hinge plate I () through pins ();'}{'b': 4', '2', '4', '6', '5, 'one end of the pull rod () is hingedly connected to the hinge plate I () through pins, and another end of the pull rod () is hingedly connected to a hinge plate II () through fixed pins ();'}{'b': 3', '1', '3', '4, 'one end of the hydraulic cylinder I () is hingedly connected to the rear mounted seat (), and another end of the hydraulic cylinder I () is hingedly connected to the pull rod ();'}{'b': '12', 'the front mounted seat () is fixed on a front portion of the rear rack of the land leveler;'}{'b': 10', '12', '10', '8', '9, 'one end of the oscillating rod () is hingedly connected to the front mounted seat (), and another end of the oscillating rod () is hingedly connected to a hinge plate III () through the pins ();'}{'b': 11', '12 ...

Device for detaching a cover from a base

A device for detaching a cover adhesively attached to a base is provided. The device includes a support plate for supporting the base, and a suction plate applying an overall and uniform attracting action to the cover by means of a vacuum. The device further includes a driving unit to pull the suction plate away from the base. The device further includes a heating element to heat and soften adhesive, thereby weakening the adhesive bond between the base and the cover and allowing the release of the cover from the base.

MONOCLONAL ANTIBODIES AGAINST GLYPICAN-3

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Glypican-3 with high affinity. Nucleic acid molecules encoding Glypican-3 antibodies, expression vectors, host cells and methods for expressing the Glypican-3 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the Glypican-3 antibodies are also provided. Methods for detecting Glypican-3, as well as methods for treating various Glypican-3-related conditions, including hepatocellular cancer, are disclosed. 1. An isolated nucleic acid molecule encoding;(a) a heavy chain of an anti-Glypican-3 antibody, or antigen-binding portion thereof, wherein the heavy chain variable region comprises the amino acid sequence of SEQ ID NO: 19, 20 or 21; or(b) a light chain of an anti-Glypican-3 antibody, or antigen-binding portion thereof, wherein the light chain variable region comprises the amino acid sequence of SEQ ID NO: 22, 23 or 24.2. The nucleic acid molecule of claim 1 , wherein the heavy chain variable region comprises the amino acid sequence of SEQ ID NO: 19.3. The nucleic acid molecule of claim 1 , wherein the heavy chain variable region comprises the amino acid sequence of SEQ ID NO: 20.4. The nucleic acid molecule of claim 1 , wherein the heavy chain variable region comprises the amino acid sequence of SEQ ID NO: 21.5. The nucleic acid molecule of claim 1 , wherein the light chain variable region comprises the amino acid sequence of SEQ ID NO: 22.6. The nucleic acid molecule of claim 1 , wherein the light chain variable region comprises the amino acid sequence of SEQ ID NO: 23.7. The nucleic acid molecule of claim 1 , wherein the light chain variable region comprises the amino acid sequence of SEQ ID NO: 24.8. The nucleic acid molecule of claim 2 , comprising the nucleotide sequence of SEQ ID NO: 25.9. The nucleic acid molecule of claim 3 , comprising the nucleotide sequence of SEQ ...

Packet capture via packet tagging

Techniques are disclosed for capturing network traffic in a virtualized computing environment. A packet to be captured in the virtualized environment is identified. The packet is tagged using a pattern of one or more bits in a header of the packet. The pattern indicates that the packet is to be traced. The pattern is propagated to an outer layer during encapsulation of the packet. A header of the encapsulated packet includes the pattern of one or more bits. At least one network device is caused to mirror identified packets based on the reserved bit.

Voltage regulator module

A voltage regulator module with a vertical layout structure includes a circuit board assembly, an electroplated region and a magnetic core assembly. The circuit board assembly includes a printed circuit board and at least one switch element. The printed circuit board includes a first surface, a second surface, a plurality of lateral surfaces, an accommodation space and a conductive structure. The switch element is disposed on the first surface. A conduction part is formed on the second surface. The conductive structure is perpendicular to the printed circuit board and disposed within the accommodation space. The electroplated region is formed on the corresponding lateral surface, arranged between the conduction part and the first surface, and electrically connected with the conduction part and the switch element. The magnetic core assembly is accommodated within the accommodation space. Consequently, an inductor is defined by the conductive structure and the magnetic core assembly collaboratively.

ISOLATION STRUCTURE OF HIGH-VOLTAGE DRIVING CIRCUIT

An isolation structure of a high-voltage driving circuit includes a P-type substrate and a P-type epitaxial layer; a high voltage area, a low voltage area and a high and low voltage junction terminal area are arranged on the P-type epitaxial layer; a first P-type junction isolation area is arranged between the high and low voltage junction terminal area and the low voltage area, and a high-voltage insulated gate field effect tube is arranged between the high voltage area and the low voltage area; two sides of the high-voltage insulated gate field effect tube and an isolation structure between the high-voltage insulated gate field effect tube and a high side area are formed as a second P-type junction isolation area. 1. An isolation structure of high-voltage driving circuit , comprising: a P-type substrate; a P-type epitaxial layer arranged on the P-type substrate; a low-voltage region and a high-voltage region arranged on the P-type epitaxial layer; a HV-LV junction terminal region arranged between the low-voltage region and the high-voltage region; a first P-type junction isolation region arranged between the HV-LV junction terminal region and the low-voltage region , said first P-type junction isolation region being composed of a P-type buried layer and a first P-type well; a second P-type junction isolation region arranged in the interior zone of the first P-type junction isolation region and working with the first P-type junction isolation region to enclose an isolated region; a high-voltage insulated gate field effect transistor (IGFET) arranged in the isolated region and utilizing the HV-LV junction terminal region as its drift region; wherein , the high-voltage region is partially located in the isolated region , the partial high-voltage region in the isolated region comprises a first N-type deep well arranged in the P-type substrate and a first N-type well region arranged in the P-type epitaxial layer , and the N-type well region is on the top surface of the ...

ANTI-CD27 ANTIBODIES AND USES THEREOF

This disclosure provides isolated antibodies that bind specifically to CD27 with high affinity. The disclosure provides methods for treating a subject afflicted with a cancer comprising administering to the subject a therapeutically effective amount of an anti-CD27 antibody as monotherapy or in combination with a checkpoint inhibitor, such as an anti-PD-1, anti-PD-L1, or anti-CTLA-4 antibody. 1. A monoclonal antibody or an antigen-binding portion thereof that specifically binds to human CD27 and does not block binding of its CD70 ligand as measured by surface plasmon resonance (SPR) or flow cytometry , wherein the antibody or fragment thereof:{'sub': 'D', '(a) binds to human CD27 with a Kof about 100 nM or lower, about 90 nM or lower, about 80 nM or lower, about 70 nM or lower, about 60 nM or lower, about 50 nM or lower, about 40 nM or lower, between about 1 nM and about 100 nM, between about 10 nM and about 70 nM, between about 10 nM and about 50 nM, or between about 40 nM and about 45 nM, and/or'}{'sub': '50', '(b) induces NF-κB and MAPK signaling with an ECof about 0.5 nM or lower, about 0.4 nM or lower, about 0.3 nM or lower, between about 0.005 nM and about 0.5 nM, between about 0.01 nM and about 0.4 nM, or between about 0.02 nM and about 0.25 nM in naïve human T cells stimulated by an anti-CD3 antibody and an anti-CD28 antibody.'}2. A monoclonal antibody or an antigen-binding portion thereof that specifically binds to an epitope located within discontinuous regions spanning approximately amino acid residues 21-41 and 52-57 of human CD27 , a sequence of which is set forth as SEQ ID NO: 1 , as determined by hydrogen-deuterium exchange mass spectrometry (HDX-MS) and/or fast photochemical oxidation of proteins (FPOP) epitope mapping.3. A monoclonal antibody or an antigen-binding portion thereof that specifically binds to human CD27 , which:{'sub': 'H', '(a) comprises a heavy chain variable region (V) comprising a CDR1 comprising consecutively linked amino acids ...

Magnetic device and power converter with same

A magnetic device includes two common magnetic legs, a plurality of coupled magnetic legs, and two windings. The first winding includes a first input part, a first intermediate part and a first output part. The second winding includes a second input part, a second intermediate part and a second output part. The first input part is disposed between the first common magnetic leg and the first coupled magnetic leg. The second input part is disposed between the second common magnetic leg and the first coupled magnetic leg. The first intermediate part and the second intermediate part are disposed between every two adjacent coupled magnetic legs. The first output part is disposed between the first common magnetic leg and the last coupled magnetic leg. The second output part is disposed between the second common magnetic leg and the last coupled magnetic leg.

HUMAN MONOCLONAL ANTIBODIES TO O8E

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to O8E with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer. 1. An isolated human monoclonal antibody or an antigen-binding portion thereof , wherein the antibody:{'sub': 'D', 'sup': '−7', '(a) binds to human O8E with a Kof 1×10M or less; and'}(b) binds to a breast cell carcinoma tumor cell line.2. The antibody of claim 1 , wherein said antibody is internalized.3. The antibody of claim 1 , wherein the breast cell carcinoma tumor cell line is SKBR3 cell line.4. The antibody of claim 1 , wherein said antibody lacks fucose residues.5. The antibody of claim 1 , which comprises a heavy chain variable region that comprises CDR1 claim 1 , CDR2 claim 1 , and CDR3 domains; and a light chain variable region that comprises CDR1 claim 1 , CDR2 claim 1 , and CDR3 domains claim 1 , wherein the heavy chain variable region and light chain variable region CDR1 claim 1 , CDR2 claim 1 , and CDR3 domains are selected from the group consisting of:(a) a heavy chain variable region CDR1 comprising SEQ ID NO: 1; a heavy chain variable region CDR2 comprising SEQ ID NO: 16; a heavy chain variable region CDR3 comprising SEQ ID NO: 21; a light chain variable region CDR1 comprising SEQ ID NO: 26; a light chain variable region CDR2 comprising SEQ ID NO: 31; and a light chain variable region CDR3 comprising SEQ ID NO: 36;(b) a heavy chain variable region CDR1 comprising SEQ ID NO: 12; a heavy chain variable region CDR2 comprising SEQ ID NO: 17; a heavy chain variable region CDR3 comprising SEQ ID NO: 22; a light chain variable region CDR1 ...

Wheel fastening system for direction-precise mobile robot with wheels

A wheel fastening system for a wheeled mobile robot includes a chassis, a motor, a wheel, a thrust bearing, a stud, and a screw. The chassis has a base and a cover. The cover covers the base. The motor is disposed in the chassis. The motor has a shaft. The wheel has a hub by which the wheel is centered on the shaft of the motor. The thrust bearing is an interference fit between the wheel and the chassis and provides axial support for the wheel. The stud passes through the hub of the wheel to couple to the shaft of the motor. The screw is coupled to the stud, and is clamped between the base and the cover of the chassis. The stud and the screw prevent the wheel from radially shifting relative to the shaft of the motor.

SELF-ADAPTIVE SYNCHRONOUS RECTIFICATION CONTROL SYSTEM AND METHOD OF ACTIVE CLAMP FLYBACK CONVERTER

The invention discloses a self-adaptive synchronous rectification control system and a self-adaptive synchronous rectification control method of an active clamp flyback converter. The control system comprises a sampling and signal processing circuit, a control circuit with a microcontroller as a core and a gate driver. According to the control method, a switching-on state, an early switching-off state, a late switching-off state and an exact switching-off state of a secondary synchronous rectifier of the active clamp flyback converter can be directly detected, and the synchronous rectifier and a switching-on time of the synchronous rectifier in next cycle can be controlled according to a detection result. After several cycles of self-adaptive control, the synchronous rectifier enters the exact switching-on state, thus avoiding oscillation of an output waveform of the active clamp flyback converter. 1. A self-adaptive synchronous rectification control system of an active clamp flyback converter , comprising:a sampling and signal processing circuit, a control circuit with a microcontroller as a core, and a gate driver, wherein an input end of the sampling and signal processing circuit is connected with a drain of a secondary synchronous rectifier of the active clamp flyback converter, a first output end and a second output end of the sampling and signal processing circuit are both connected with the control circuit with the microcontroller, an output end of the control circuit with the microcontroller is connected with an input end of the gate driver, and an output end of the gate driver is connected with a gate of the secondary synchronous rectifier of the active clamp flyback converter; wherein, a first comparator,', 'a second comparator,', 'a counter,', 'a register,', 'a control unit, and', 'a pulse width modulation (PWM) timer,, 'the control circuit with the microcontroller compriseswherein the first comparator, the second comparator and the PWM timer are actual ...

Distance sensor

A distance sensor includes an IR emitter, an IR receiver, and an annular support. The IR emitter includes a transmitter. The IR receiver includes a number of transceivers. The annular support includes a transmitter support and a transceiver support. The transmitter support is located centrally within the transceiver support. The transmitter is arranged on the transmitter support. The transmitter emits infrared signals through a top of the annular support to a transmission lens, and the transmission lens scatters the infrared light. The transceivers are arranged on the transceiver support and positioned around a periphery of the annular support to receive reflected infrared signals.

Power Module of Square Flat Pin-Free Packaging Structure

A power module of a square flat pin-free packaging structure for suppressing the power module from being excessively high in local temperature. The power module includes an insulating resin, a driving chip, a plurality of power chips, and a plurality of metal electrode contacts. The driving chip, the power chips, and the metal electrode contacts are electrically connected through a metal lead according to a predetermined circuit. A plurality of metal heat dissipating disks used for heat dissipation of the power chips and a driving chip lead frame are disposed at the bottom of the insulating resin. A plurality of metal power chip lead frames are disposed on the metal heat dissipating disks, the power chips are disposed on the power chip lead frames, and the drain electrodes of the power chips are electrically connected to the metal heat dissipating disks.

GATE DRIVE CIRCUIT FOR REDUCING REVERSE RECOVERY CURRENT OF POWER DEVICE

The present invention discloses a gate drive circuit for reducing a reverse recovery current of a power device, and belongs to the field of basic electronic circuit technologies. The gate drive circuit includes a high-voltage LDMOS transistor, a diode forming a freewheeling path when the diode is turned on or a low-voltage MOS transistor in anti-parallel connection with a body diode, and a voltage detection circuit. When the power device is turned off, a freewheeling current produced by an inductive load flows through a freewheeling diode, the voltage detection circuit detects that the freewheeling diode is turned on, and an output signal is processed by a control circuit, to cause the drive circuit to output a high level, so that channels of the power device and the high-voltage LDMOS transistor are turned on, the freewheeling current flows through the conductive channels, almost not through the freewheeling diode, and there is no reverse recovery current in the freewheeling diode at this time, thereby reducing the reverse recovery current of the power device. 1. A gate drive circuit for reducing a reverse recovery current of a power device , comprising:a high-voltage LDMOS transistor, a drain of the high-voltage LDMOS transistor and a drain of the power device being jointly connected to a bus voltage, and a gate of the high-voltage LDMOS transistor and a gate of the power device being jointly connected to an output terminal of a drive circuit;a first diode, an anode of the first diode being connected to a source of the high-voltage LDMOS transistor, and a cathode of the first diode and a source of the power device being jointly connected to a ground;a switch transistor being in series connection with the source of the high-voltage LDMOS transistor, a current input terminal of the switch transistor and the source of the power device being connected to the ground, and a current output terminal of the switch transistor being connected to the source of the high- ...

Method and apparatus for multi-spray rrc process with dynamic control

A multi-spray RRC process with dynamic control to improve final yield and further reduce resist cost is disclosed. In one embodiment, a method, includes: dispensing a first layer of solvent on a semiconductor substrate while spinning at a first speed for a first time period; dispensing the solvent on the semiconductor substrate while spinning at a second speed for a second time period so as to transform the first layer to a second layer of the solvent; dispensing the solvent on the semiconductor substrate while spinning at a third speed for a third time period so as to transform the second layer to a third layer of the solvent; dispensing the solvent on the semiconductor substrate while spinning at a fourth speed for a fourth time period so as to transform the third layer to a fourth layer of the solvent; and dispensing a first layer of photoresist on the fourth layer of the solvent while spinning at a fifth speed for a fifth period of time.

Medical apparatus for atomizing water, gas, and liquid medication

A medical apparatus is provided with a housing; a mixer including a gas reservoir; a water unit for flowing water to the mixer; a gas unit for flowing gas to the gas reservoir; a gas output for flowing gas from the gas reservoir to the mixer so that gas is mixed with water to form a first mixture, a line for carrying the first mixture; a valve disposed downstream of the line; Venturi tubes disposed downstream of the valve; medication units for containing liquid medication, each medication unit being in fluid communication with the corresponding Venturi tube; a mixing device disposed downstream of the Venturi tubes to atomize the liquid medication and the first mixture to form a second mixture; a control panel electrically connected to the gas reservoir, the mixer, the valve, the medication units, and the mixing device respectively; and an outlet.

HIGH-CURRENT N-TYPE SILICON-ON-INSULATOR LATERAL INSULATED-GATE BIPOLAR TRANSISTOR

A high-current, N-type silicon-on-insulator lateral insulated-gate bipolar transistor, including: a P-type substrate, a buried-oxide layer disposed on the P-type substrate, an N-type epitaxial layer disposed on the oxide layer, and an N-type buffer trap region. A P-type body region and an N-type central buffer trap region are disposed inside the N-type epitaxial layer; a P-type drain region is disposed in the buffer trap region; N-type source regions and a P-type body contact region are disposed in the P-type body region; an N-type base region and a P-type emitter region are disposed in the buffer trap region; gate and field oxide layers are disposed on the N-type epitaxial layer; polycrystalline silicon gates are disposed on the gate oxide layers; and a passivation layer and metal layers are disposed on the surface of the symmetrical transistor. P-type emitter region output and current density are improved without increasing the area of the transistor. 1. A high-current N-type SOI-LIGBT , comprising:a P-type silicon substrate;a buried oxide layer arranged on the P-type silicon substrate;an N-type epitaxial layer arranged on the buried oxide layer;an N-type central buffer well region arranged in the N-type epitaxial layer;a P-type emitter region arranged in the N-type central buffer well region;and a portion of emitter metal connected to the P-type emitter region;wherein:a first N-type base region and a second N-type base region are arranged in the N-type central buffer well region, and the first N-type base region and the second N-type base region are at two sides of the P-type emitter region and in symmetry to the P-type emitter region;a first portion of base metal is connected to the first N-type base region, a second portion of base metal is connected to the second N-type base region, a first P-type body region and a second P-type body region are arranged at two sides of the N-type central buffer well region respectively, and the first P-type body region and the ...

Breast support device for radiotherapy

A breast support device for radiation therapy includes a cuplike body with a through aperture. The cuplike body has a base portion and a compression portion connected continuously forming a concave inner surface, the compression portion is extended from the base portion, the concave inner surface have contours that fit over the female patient's breast as patient been in a predetermined posture. The through aperture is formed on the cuplike body to receive a portion of the female patient's breast through, it has a contour curve defined by a cutting plane and the contours of the patient's breast.

CONTROL METHOD FOR IMPROVING DYNAMIC RESPONSE OF SWITCH POWER

A control method for improving dynamic response of switch power is based on a closed-loop control system comprising a sampling module, a dynamic control module, an error calculation module, a PID module, a mode control module, and a PWM module. The sampling module samples an output voltage Vo, and the dynamic control module compares the output voltage Vo with a set maximum voltage Vomax, a set minimum voltage Vomin, and a reference voltage Vref, so as to determine whether to adopt a dynamic mode. In the dynamic mode, when the output voltage Vo changes greatly, the output voltage Vo is rapidly restored to a stable voltage by inputting large power or small power. 1the sampling module comprises a sampling circuit and a sampling calculation module, the sampling circuit outputs a partial voltage through the switch power to obtain the information of the output voltage, and the sampling calculation module calculates the output voltage as Vo according to the result of the sampling circuit;the dynamic control module comprises a voltage monitoring module and a slope calculation module; the voltage monitoring module receives the sampling result of the output voltage Vo outputted by the sampling module and determines whether to adopt a dynamic mode according to the relationship between Vo and a set maximum voltage Vomax, a set minimum voltage Vomin, and a reference voltage Vref respectively, wherein Vomin Подробнее

DC/DC CONVERTER AND CONTROL METHOD THEREOF

A DC/DC converter and a control method thereof are disclosed. The DC/DC converter comprises: an output voltage regulation circuit configured to regulate an output voltage of the DC/DC converter, so as to output a duty cycle regulation signal; a PWM generator electrically coupled to the output voltage regulation circuit and configured to generate a first duty cycle signal according to a first clock signal and the duty cycle regulation signal; a detection circuit configured to output a control signal according to a second clock signal and a feedback signal, wherein the feedback signal is configured to detect whether or not the transient change of an input voltage of the DC/DC converter occurs; and a CBC regulation circuit electrically coupled to the PWM generator and the detection circuit, and configured to receive the first duty cycle signal and the control signal and output a second duty cycle signal. 1. A DC/DC converter comprising:an output voltage regulation circuit configured to regulate an output voltage of the DC/DC converter, so as to output a duty cycle regulation signal;a PWM generator electrically coupled to the output voltage regulation circuit, and configured to generate a first duty cycle signal according to a first clock signal and the duty cycle regulation signal;a detection circuit configured to output a control signal according to a second clock signal and a feedback signal, wherein the second clock signal and the first clock signal keep the first duty cycle signal and the control signal in a same frequency, and the feedback signal is used to detect whether or not a transient change of an input voltage of the DC/DC converter occurs; anda CBC regulation circuit electrically coupled to the PWM generator and the detection circuit, and configured to output a second duty cycle signal according to the first duty cycle signal and the control signal.2. The DC/DC converter according to claim 1 , wherein the feedback signal is at least one selected from the ...

TRANSVERSE ULTRA-THIN INSULATED GATE BIPOLAR TRANSISTOR HAVING HIGH CURRENT DENSITY

A transverse ultra-thin insulated gate bipolar transistor having current density includes: a P substrate, where the P substrate is provided with a buried oxide layer thereon, the buried oxide layer is provided with an N epitaxial layer thereon, the N epitaxial layer is provided with an N well region and P base region therein, the P base region is provided with a first P contact region and an N source region therein, the N well region is provided with an N buffer region therein, the N well region is provided with a field oxide layer thereon, the N buffer region is provided with a P drain region therein, the N epitaxial layer is provided therein with a P base region array including a P annular base region, the P base region array is located between the N well region and the P base region, the P annular base region is provided with a second P contact region and an N annular source region therein, and the second P contact region is located in the N annular source region. The present invention greatly increases current density of a transverse ultra-thin insulated gate bipolar transistor, thus significantly improving the performance of an intelligent power module. 11122333464541151159678317617466787812118121188101212312812810121311121266787859147878159161212aaaababbbbbabbbaabbbbabbababaabbaabbab. A transverse ultra-thin insulated gate bipolar transistor having high current density , comprising: a P substrate () , wherein the P substrate () is provided with a buried oxide layer () thereon , the buried oxide layer () is provided with an N epitaxial layer () thereon , the thickness of the N epitaxial layer () is 0.1 to 1.5 μm , the N epitaxial layer () is provided with an N well region () and a P base region () therein , the N well region () is provided with an N buffer region () therein , the N well region () is provided with a field oxide layer () thereon , a boundary of the N buffer region () abuts against a boundary of the field oxide layer () , the N buffer region () is ...

INTEGRATED BOOTSTRAP HIGH-VOLTAGE DRIVER CHIP AND TECHNOLOGICAL STRUCTURE THEREOF

Parasitic high-voltage diodes implemented by integration technology in a high-voltage level shift circuit are used for charging a bootstrap capacitor C, wherein a power supply end of the high voltage level shift circuit is a high-side floating power supply VB, and a reference ground is a floating voltage PGD that is controlled by a bootstrap control circuit. A first parasitic diode Dand a second parasitic diode Dare provided between the VB and the PGD. The bootstrap control circuit is controlled by a high-side signal and a low-side signal. 100100200200400500600700100800901000410040050050060060070070082008009009010010006007004005001007006005005. An integrated bootstrap high-voltage driver chip based on a driver circuit of a half-bridge structure , comprising a low-side channel logic circuit () and a high-side channel logic circuit () , wherein the high-side channel logic circuit () comprises a high-side signal input circuit () , a narrow pulse generation circuit () , a high-voltage level shift circuit () and a high-side channel high-basin logic circuit () composed of two pulse filtering circuits with the same structure , an RS trigger and a high-side signal output circuit; the low-side channel logic circuit () comprises a low-side signal input circuit () , a low-side delay circuit () and a low-side signal output circuit (); a high-side input signal HIN is connected to the input end of the high-side signal input circuit () , an output signal CIN of the high-side signal input circuit () is connected to the input end of the narrow pulse generation circuit () , a low-voltage set signal SET and a low-voltage reset signal RESET outputted by the narrow pulse generation circuit () are respectively connected to two input ends of the high-voltage level shift circuit () , a high-voltage set signal VRS and a high-voltage reset signal VRR outputted by the high-voltage level shift circuit () are respectively connected to two input ends of the high-side channel high-basin logic ...

DC/DC CONVERSION SYSTEM

The present disclosure relates to a DC/DC conversion system, including a plurality of switch conversion branches, each of the switch conversion branches includes: a primary side circuit, having an input end connected in parallel with an input capacitor; a transformer, having a primary winding coupled to the primary side circuit; and a secondary side circuit, coupled to a secondary winding of the transformer, wherein, input ends of the primary side circuits of the plurality of switch conversion branches are connected in series to form a system input end, output ends of the secondary side circuits of the plurality of switch conversion branches are connected in series to form a system output end, and a filter circuit is connected in parallel with the system output end. 1. A DC/DC conversion system , comprising: a primary side circuit, having an input end connected in parallel with an input capacitor;', 'a transformer, having a primary winding coupled to the primary side circuit; and', 'a secondary side circuit, coupled to a secondary winding of the transformer,, 'a plurality of switch conversion branches, each of the switch conversion branches compriseswherein, input ends of the primary side circuits of the plurality of switch conversion branches are connected in series to form a system input end, output ends of the secondary side circuits of the plurality of switch conversion branches are connected in series to form a system output end, and a filter circuit is connected in parallel with the system output end.2. The DC/DC conversion system according to claim 1 , wherein the primary side circuit comprises a full-bridge circuit or a half-bridge circuit.3. The DC/DC conversion system according to claim 2 , wherein in any two adjacent primary side circuits claim 2 , a phase difference between driving signals of switches at corresponding positions is 180 deg/S claim 2 , and S is a number of the plurality of switch conversion branches.4. The DC/DC conversion system according ...

ANTI-HUMAN mIgA ANTIBODIES CAPABLE OF LYSING mIgA-B LYMPHOCYTES AND DECREASING IgA PRODUCTION

Disclosed herein is an anti-migis-ααantibody specific for the migis-α of human mα chain that can bind to mIgA on B lymphocytes, cause the lysis of mIgA-expressing B lymphocytes, and decrease IgA production by IgA-secreting B lymphocytes. Disclosed further is a pharmaceutical composition comprising the anti-migis-α antibody and a pharmaceutically acceptable carrier. Disclosed further is a method for lysing mIgA-expressing B lymphocytes and reducing IgA production in a human subject in vivo by employing an antibody specific for the migis-α of human mα chain that can bind to mIgA on B lymphocytes, cause the lysis of mIgA-expressing B lymphocytes, and decrease IgA production by IgA-secreting B lymphocytes. Disclosed herein is also a method for treating a disease in a subject, comprising administering to the subject an antibody specific for the migis-α of human mα chain that can bind to mIgA on B lymphocytes, thereby lysing mIgA-expressing B lymphocytes and reducing IgA production in the immune system of the subject. In addition, Disclosed also is use of said anti-migis-α antibody or said fragment thereof for treating a disease in a subject that can benefit from the elimination of mIgA-expressing cells or the reduction of IgA antibodies in the immune system.

Conductive substrate of a display device

A conductive substrate of a display device has an electrically insulating substrate and a plurality of rows of electrical pin connecting areas, a plurality of rows of patterned input voltage lines and a plurality of rows of patterned grounded lines formed on the electrically insulated substrate. Each of the rows of the electrical pin connecting areas includes a plurality of electrical pin connecting areas electrically isolated and spaced from each other in a line. The rows of the patterned input voltage lines are respectively adjacent to the rows of the electrical pin connecting areas, and the rows of the patterned grounded lines are respectively adjacent to the rows of the electrical pin connecting areas. Besides, two opposite sides of at least one row of the patterned input voltage lines are respectively electrically connected with the input voltage pin contacts of two neighboring rows of the electrical pin connecting areas while two opposite sides of at least one row of the patterned grounded lines are respectively electrically connected with the grounded pin contacts of two neighboring rows of the electrical pin connecting areas.

DC-TO-DC CONVERTER CIRCUIT AND CIRCUIT BOARD LAYOUT STRUCTURE FOR THE SAME

The present application discloses a DC-to-DC converter circuit and a circuit board layout structure for the same. The DC-to-DC converter circuit is electrically connected between a first power supply side and a second power supply side, and comprises a first branch with a primary side coupled to the first power supply side and a secondary side coupled to the second power supply side; a second branch with a primary side coupled to the first power supply side and a secondary side coupled to the second power supply side; and a first inductor. The secondary sides of the first branch and the second branch are connected in series via the first inductor. 1. A DC-to-DC converter circuit electrically connected between a first power supply side and a second power supply side , comprising:a first branch with a primary side coupled to the first power supply side and a secondary side coupled to the second power supply side;a second branch with a primary side coupled to the first power supply side and a secondary side coupled to the second power supply side; anda first inductor,wherein, the secondary sides of the first branch and the second branch are connected in series via the first inductor.2. The DC-to-DC converter circuit according to claim 1 , wherein a first transformer, comprising a primary winding and a secondary winding;', 'a first primary switching circuit with one end electrically connected to the primary winding of the first transformer and the other end electrically connected to the first power supply side; and', 'a first secondary rectifier circuit with one end electrically connected to the secondary winding of the first transformer and the other end electrically connected to the second power supply side and one end of the first inductor, and the second branch comprises:', 'a second transformer, comprising a primary winding and a secondary winding;', 'a second primary switching circuit with one end electrically connected to the primary winding of the second ...

Human monoclonal antibodies to cd70

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to CD70 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for treating cancer, autoimmune disease, inflammation and viral infections.

Human Monoclonal Antibodies To O8E

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to O8E with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.

Human monoclonal antibodies to protein tyrosine kinase 7 (PTK7)

The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PTK7 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PTK7, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PTK7 antibodies.

Human monoclonal antibodies to CD70

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to CD70 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for treating cancer, autoimmune disease, inflammation and viral infections.

Human monoclonal antibodies to O8E

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to O8E with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.

Human monoclonal antibodies to O8E

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to O8E with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.

Treating lung cancer using human monoclonal antibodies to protein tyrosine kinase 7 (PTK7)

The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PTK7 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PTK7, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PTK7 antibodies.

Human monoclonal antibodies to O8E

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to O8E with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.

Human monoclonal antibodies to cd70

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to CD70 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for treating cancer, autoimmune disease, inflammation and viral infections.

Human monoclonal antibodies to protein tyrosine kinase 7 ( ptk7 ) and their use

The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PTK7 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PTK7, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PTK7 antibodies.

Human monoclonal antibodies to protein tyrosine kinase 7 (ptk7) and methods for using anti-ptk7 antibodies

HUMAN MONOCLONAL ANTIBODIES TO PROTEIN TYROSINE KINASE 7 (PTK7) AND METHODS FOR USING ANTI-PTK7 ANTIBODIES The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PTK7 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. lmmunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PTK7, as well as methods for treating various diseases, including cancer and infectious diseases, using anti PTK7 antibodies.No suitable figure.

Human monoclonal antibodies to cd70

Human monoclonal antibodies to CD70

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to CD70 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for treating cancer, autoimmune disease, inflammation and viral infections.

Human monoclonal antibodies to cd70

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to CD70 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for treating cancer, autoimmune disease, inflammation and viral infections.

Human monoclonal antibodies to CD70

Un anticuerpo monoclonal humano aislado o parte de unión a antígeno del mismo, que comprende: (a) una CDR1 de región variable de cadena pesada que comprende la secuencia de CDR1 como se muestra en la Figura 1A; (b) una CDR2 de región variable de cadena pesada que comprende la secuencia de CDR2 como se muestra en la Figura 1A; (c) una CDR3 de región variable de cadena pesada que comprende la secuencia de CDR3 como se muestra en la Figura 1A; (d) una CDR1 de región variable de cadena ligera que comprende la secuencia de CDR1 como se muestra en la Figura 1B; (e) una CDR2 de región variable de cadena ligera que comprende la secuencia de CDR2 como se muestra en la Figura 1B; y (f) una CDR3 de región variable de cadena ligera que comprende la secuencia de CDR3 como se muestra en la Figura 1B; en donde el anticuerpo se une específicamente a CD70. An isolated human monoclonal antibody or antigen binding part thereof, comprising: (a) a heavy chain variable region CDR1 comprising the CDR1 sequence as shown in Figure 1A; (b) a heavy chain variable region CDR2 comprising the CDR2 sequence as shown in Figure 1A; (c) a heavy chain variable region CDR3 comprising the CDR3 sequence as shown in Figure 1A; (d) a light chain variable region CDR1 comprising the CDR1 sequence as shown in Figure 1B; (e) a light chain variable region CDR2 comprising the CDR2 sequence as shown in Figure 1B; and (f) a light chain variable region CDR3 comprising the CDR3 sequence as shown in Figure 1B; wherein the antibody specifically binds to CD70.

Humane, monoklonale antistoffer mot CD70

Sammendrag Foreliggende beskrivelse tilveiebringer isolerte monoklonale antistoffer, spesielt humane monoklonale antistoffer, som spesifikt binder til CD70 med høy affinitet. Nukleinsyremolekyler som koder for antistoffene ifølge beskrivelsen, uttrykksvektorer, vertsceller og fremgangsmåter for å uttrykke antistoffene ifølge beskrivelsen er også tilveiebrakt. Immunkonjugater, bispesifikke molekyler og farmasøytiske preparater som omfatter antistoffene ifølge beskrivelsen er også tilveiebrakt. Beskrivelsen tilveiebringer også fremgangsmåter for behandling av kreft, autoimmunsykdom, betennelse og virale infeksjoner.

Human monoclonal antibodies to CD70

Disclosed is an isolated monoclonal antibody or antigen binding portion thereof comprising: a) a heavy chain variable region CDR1 comprising SEQ ID NO: 11; b) a heavy chain variable region CDR2 comprising SEQ ID NO: 16; c) a heavy chain variable region CDR3 comprising SEQ ID NO: 21; d) a light chain variable region CDR1 comprising SEQ ID NO: 26; e) a light chain variable region CDR2 comprising SEQ ID NO: 31; and f) a light chain variable region CDR3 comprising SEQ ID NO: 36. Also disclosed is the use of the antibody for the preparation of a medicament for the treatment or prevention of a disease characterized by growth of tumor cells expressing CD70 in a subject.

Human monoclonal antibodies to cd70

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to CD70 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for treating cancer, autoimmune disease, inflammation and viral infections.

Human monoclonal antibodies to cd70

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to CD70 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for treating cancer, autoimmune disease, inflammation and viral infections.

Human monoclonal antibodies to CD70

Human monoclonal antibodies to protein tyrosine kinase 7 ( PTK7 ) and their use

The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PTK7 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PTK7, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PTK7 antibodies.

Human monoclonal antibodies to o8e

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to O8E with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.

Human monoclonal antibodies to o8e

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to O8E with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.

Human monoclonal antibodies to O8E

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to O8E with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.

Human monoclonal antibodies to o8e

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to O8E with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.

Humane monoklonale antistoffer mot O8E

Sammendrag Den foreliggende beskrivelsen tilveiebringer isolerte monoklonale antistoffer, spesielt humane monoklonale antistoffer som spesifikt binder til 08E med høy affinitet. Nukleinsyremolekyler som koder for antistoffene ifølge denne beskrivelsen, uttrykksvektorer, vertsceller og fremgangsmåter for å uttrykke antistoffene ifølge denne beskrivelsen er også tilveiebrakt. Immunkonjugater, bi-spesifikke molekyler og farmasøytiske preparater som omfatter antistoffene ifølge denne beskrivelsen er også tilveiebrakt. Farmasøytiske preparatene i henhold til foreliggende oppfinnelse kan også anvendes for å behandle kreft.

Human monoclonal antibodies to O8E

Disclosed are human monoclonal antibodies that bind specifically to human O8E (also known as VTCN1). The antibodies can be used as therapeutic agents to treat tumours overexpressing O8E.

Human monoclonal antibodies to o8e

HUMAN MONOCLONAL ANTIBODIES TO 08E The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to 08E with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer. Figure 20

Human monoclonal antibodies to o8e

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to O8E with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.

Human monoclonal antibodies to O8E

Human monoclonal antibodies to o8e

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to O8E with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.

Human monoclonal antibodies to protein tyrosine kinase 7 (PTK7) and methods for using anti-PTK7 antibodies

The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PTK7 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PTK7, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PTK7 antibodies.

Human monoclonal antibodies to protein tyrosine kinase 7 (ptk7) and their use

Human monoclonal antibodies to protein tyrosine kinase 7 ( PTK7 ) and their use

The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PTK7 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PTK7, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PTK7 antibodies.

Human monoclonal antibodies to protein tyrosine kinase 7 (ptk7) and their use

The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PTK7 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PTK7, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PTK7 antibodies.

HUMAN MONOCLONAL ANTIBODIES FOR PROTEINTYROSINKINASE 7 (PTK7) AND THEIR USE

Human monoclonal antibodies against the protein Tyrosine Kinase 7 (PTK7) and its use

Un anticuerpo monoclonal humano aislado, o una porción de unión al antígeno del mismo, en donde el anticuerpo: (a) se une específicamente a PTK7 humana; y (b) se une a la línea celular tumoral de Wilms que tiene el Núm. de Acc. ATCC CRL-1441 con una CE50 de 4,0 nM o menos, en un análisis que comprende la incubación de 1 x 105 células con el anticuerpo a una concentración de partida de 30 μg/ml y la dilución seriada del anticuerpo a una dilución 1:10, y (c) se une al mismo epítopo en PTK7 humana como un anticuerpo de referencia que comprende: (i) una región variable de la cadena pesada que comprende la secuencia de aminoácidos del SEQ ID NO: 2 y 10 una región variable de la cadena ligera que comprende la secuencia de aminoácidos del SEQ ID NO: 7; o (ii) una región variable de la cadena pesada que comprende la secuencia de aminoácidos del SEQ ID NO: 3 y una región variable de la cadena ligera que comprende la secuencia de aminoácidos del SEQ ID NO: 8; o (iii) una región variable de la cadena pesada que comprende la secuencia de aminoácidos del SEQ ID NO: 4 y una región variable de la cadena ligera que comprende la secuencia de aminoácidos del SEQ ID NO: 10. An isolated human monoclonal antibody, or an antigen binding portion thereof, wherein the antibody: (a) specifically binds to human PTK7; and (b) binds to the Wilms tumor cell line that has Acc. No. ATCC CRL-1441 with an EC50 of 4.0 nM or less, in an analysis comprising incubation of 1 x 105 cells with the antibody at a starting concentration of 30 μg / ml and the serial dilution of the antibody at a 1:10 dilution, and (c) binds to the same epitope in human PTK7 as a reference antibody comprising: (i) a variable region of the heavy chain comprising the amino acid sequence of SEQ ID NO: 2 and 10 a variable region of the light chain comprising the amino acid sequence of SEQ ID NO: 7; or (ii) a variable region of the heavy chain comprising the amino acid sequence of SEQ ID NO: 3 and a variable region of the light ...

Human monoclonal antibodies to protein tyrosine kinase 7 (ptk7) and their use

Humane monoklonale antistoffer mot protein tyrosin kinase 7 (PTK7) og fremgangsmater for anvendelse av anti-PTK7 antistoffer

Foreliggende oppfinnelse tilveiebringer isolerte monoklonale antistoffer, spesielt humane monoklonale antistoffer, som binder spesifikt til PTK7 med høy affinitet. Nukleinsyremolekyler som koder for antistoffene ifølge oppfinnelsen, ekspresjonsvektorer, vertsceller og fremgangsmåter for ekspresjon av antistoffene ifølge oppfinnelsen er også fremskaffet. Immunkonjugater, bispesifikke molekyler og farmasøytiske sammensetninger omfattende antistoffene ifølge oppfinnelsen er også fremskaffet. Foreliggende oppfinnelse tilveiebringer også fremgangsmåter for deteksjon av PTK7, så vel som fremgangsmåter for behandling av ulike sykdommer, omfattende kreft og infeksjonssykdommer, ved anvendelse av anti-PTK7-antistoffer.

Human monoclonal antibodies to protein tyrosine kinase 7 (PTK7) and methods for using anti-PTK7 antibodies

Human monoclonal antibodies to protein tyrosine kinase 7 (ptk7) and their use

Anticorpos monoclonais humanos para a proteína tirosinacinase 7 (ptk7) e sua utilização

Human monoclonal antibodies to protein tyrosine kinase 7 (ptk7) and their use

Izolovano humano monoklonsko antitelo, ili njegov antigen-vezujući deo, pri čemu se antitelo:(a) specifično vezuje za humani PTK7; i(b) vezuje za ćelijsku liniju Wilmsovog tumora koja ima ATCC Acc No. CRL-1441 sa vrednosšću EC50 od 4.0 nM ili manjom, u testu koji podrazumeva inkubaciju 1 x 105 ćelija sa antitelom u početnoj koncentraciji od 30μg/ml i serijskim razblaženjima antitela od 1:10 diluciji; i(c) vezuje za isti epitop na humanom PTK7 kao i referentno antitelo, imajući:(i) varijabilni region teškog lanca koji sadrži amino kiselinsku sekvencu SEQ IDNO:2 i varijabilni region lakog lanca koji sadrži amino kiselinsku sekvencu SEQ ID NO:7; ili(ii) varijabilni region teškog lanca koji sadrži amino kiselinsku sekvencu SEQ ID NO:3 i varijabilni region lakog lanca koji sadrži amino kiselinsku sekvencu SEQ ID NO:8; ili(iii) varijabilni region teškog lanca koji sadrži amino kiselinsku sekvencu SEQ ID NO:4 i varijabilni region lakog lanca koji sadrži amino kiselinsku sekvencu SEQ ID NO:10.Prijava sadrži još 12 patentnih zahteva. An isolated human monoclonal antibody, or antigen-binding portion thereof, wherein the antibody: (a) specifically binds to human PTK7; and (b) binds to a Wilms tumor cell line having ATCC Acc No. CRL-1441 with an EC50 value of 4.0 nM or less, in a test involving incubation of 1 x 105 cells with antibody at an initial concentration of 30μg / ml and serial dilutions of antibody of 1:10 dilution; and (c) binds to the same epitope on human PTK7 as the reference antibody, having: (i) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 2 and a light chain variable region comprising the amino acid sequence of SEQ ID NO: 7; or (ii) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 3 and a light chain variable region comprising the amino acid sequence of SEQ ID NO: 8; or (iii) a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 4 and a light chain variable region ...

Human monoclonal antibodies to protein tyrosine kinase 7 (ptk7) and their use

Human monoclonal antibodies to protein tyrosine kinase 7 (PTK7) and their use

An antibody that binds to human protein tyrosine kinase 7 (PTK7) and comprises the heavy chain CDR1, CDR2 and CDR3 regions having SEQ ID NOs: 12, 16, and 20 respectively and the light chain CDR1, CDR2 and CDR3 regions having SEQ ID NOs: 25, 31 and 37. The antibody can be used to treat pancreatic or breast cancer.

Human monoclonal antibodies to protein tyrosine kinase 7 (ptk7) and methods for using anti-ptk7 antibodies

The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PTK7 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PTK7, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PTK7 antibodies.

Human monoclonal antibodies to protein tyrosine kinase 7 ( ptk7 ) and their use

The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PTK7 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PTK7, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PTK7 antibodies.

Human monoclonal antibodies to protein tyrosine kinase 7 (ptk7) and their use

The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PTK7 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PTK7, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PTK7 antibodies.

Human monoclonal antibodies to protein tyrosine kinase 7 ( PTK7 ) and their use

Human monoclonal antibodies to protein tyrosine kinase 7 (ptk7) and their use

The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PTK7 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PTK7, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PTK7 antibodies.

Monoclonal antibodies against glypican-3

Provided are isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Glypican-3 with high affinity. Nucleic acid molecules encoding Glypican-3 antibodies, expression vectors, host cells and methods for expressing the Glypican-3 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising Glypican-3 antibodies are also disclosed. Method for detecting Glypican-3, as well as methods for treating various Glypican-3 related conditions, including heptacellular cancer, are disclosed.

Monoclonal antibodies against glypican-3

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Glypican-3 with high affinity. Nucleic acid molecules encoding Glypican-3 antibodies, expression vectors, host cells and methods for expressing the Glypican-3 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the Glypican-3 antibodies are also provided. Methods for detecting Glypican-3, as well as methods for treating various Glypican-3-related conditions, including hepatocellular cancer, are disclosed.

Anticuerpos monoclonales contra glipicano-3.

La presente invención se refiere a anticuerpos monoclonales aislados, particularmente anticuerpos monoclonales humanos que se enlazan específicamente a Glipicano-3 con alta afinidad. También se proporciona moléculas de acido nucleico que codifican anticuerpos Glipicano-3, ventores de expresión, células hospederas y métodos para expresar los anticuerpos Glipicano-3. También se proporcionan inmunoconjugados, moléculas biespecíficas y composiciones farmacéuticas que comprenden los anticuerpos Glipicano-2. Se describen métodos para detectar Glipicano-3 así como método para tratar varias condiciones relacionadas con Glipicano-3, que incluyen cáncer hepatocelular.

STACKING SYSTEM

A stacking system is disclosed and includes a circuit board, an integrated circuit, a voltage regulation module and a heat dissipation module. The integrated circuit and the voltage regulation module are opposite disposed on a first side and a second side of the circuit board. The heat dissipation module includes a first heat dissipation component and a second heat dissipation component located at a top surface of the integrated circuit and the bottom surface of the voltage regulation module. The second heat dissipation component includes a base and an extended arm. The base is in thermal contact with bottom surface of the voltage regulation module. The extended arm is extended from the base to the first heat dissipation component and in thermal contact with the first heat dissipation component.

Swivel hinge

A swivel hinge has a base plate, a first loop, a first rotating board, a second loop, a mounting member, a second rotating board, a pivot member, a third loop, a third rotating board, and a locking ring. When the display panel rotates relative to the main board in a same plane, the third rotating board will not rotate, only the first and second rotating boards rotate relative to the base plate and provide an anchor and limitation function. When a direction of a camera on the display is to be adjusted, the third rotating board rotates with the second rotating board, thus the camera can rotate according to the shooting angle.

Mobile phone cover hinge

A mobile phone cover hinge has a driven block slidably mounted in a sleeve that is securely received in the mobile phone body and a driving block rotatably mounted in the cover of the mobile phone. When the cover pivots in a first direction, the driving block pushes the driven block so as to compress the first spring received in the sleeve. When the cover pivots in a second direction opposite to the first direction, the compressed first spring will facilitate the cover to return to its original position.

Elastic hinge for a notebook computer

An elastic hinge for a notebook computer has an L-like seat secured on a body of the computer, with a hole of which a section is formed as a numeral “8”. A pintle has a first part extending through a barrel, and a second part extending through the hole of the seat. The barrel has two tubular portions for the pintle extending therethrough, and a plate extending from the tubular portions and secured on a monitor of the computer. A torsional spring is provided outside the second part. When a locking member of the computer is released, under the elastic force of the torsional spring, the pintle will be rotated to automatically raise the monitor about an angle of 30° relative to the body of the computer.

ANTI-HUMAN mIgA ANTIBODIES CAPABLE OF LYSING mIgA-B LYMPHOCYTES AND DECREASING IgA PRODUCTION

Disclosed herein is an anti-migis-α antibody specific for the migis-α of human mα chain that can bind to mIgA on B lymphocytes, cause the lysis of mIgA-expressing B lymphocytes, and decrease IgA production by IgA-secreting B lymphocytes. Disclosed further is a pharmaceutical composition comprising the anti-migis-α antibody and a pharmaceutically acceptable carrier. Disclosed further is a method for lysing mIgA-expressing B lymphocytes and reducing IgA production in a human subject in vivo by employing an antibody specific for the migis-α of human mα chain that can bind to mIgA on B lymphocytes, cause the lysis of mIgA-expressing B lymphocytes, and decrease IgA production by IgA-secreting B lymphocytes. Disclosed herein is also a method for treating a disease in a subject, comprising administering to the subject an antibody specific for the migis-α of human mα chain that can bind to mIgA on B lymphocytes, thereby lysing mIgA-expressing B lymphocytes and reducing IgA production in the immune system of the subject. In addition, Disclosed also is use of said anti-migis-α antibody or said fragment thereof for treating a disease in a subject that can benefit from the elimination of mIgA-expressing cells or the reduction of IgA antibodies in the immune system.

Hinge with an anti-bump feature

The hinge for a piece of portable electronic equipment with a cover and a base has a keyed pivot pin, a stationary leaf, a washer, a rotating positioning element, a stationary positioning element, a biasing member, and a fastener. The washer, rotating positioning element, stationary positioning element and biasing member are sequentially mounted on the keyed pivot pin and are held in place with the fastener. The rotating positioning element has detents corresponding to and simultaneously engaging protrusions on the stationary positioning element when the hinge is closed. Because the detents and protrusions are not symmetrically oriented respectively on the rotating and stationary positioning elements, the detents will only engage the protrusions in one position, a closed position. The protrusions on the stationary positioning element press against the rotating positioning element and hold the hinge open at any desired angle.