28-04-2016 дата публикации
Номер: US20160113931A1
Принадлежит:
The present disclosure provides a method of treating and/or preventing neurodegenerative diseases, such as Parkinson disease, Alzheimer disease, Huntington's disease, multiple sclerosis and amyotrophic lateral sclerosis, comprising administrating a therapeutically effective amount of a compound of formula I or a pharmaceutically acceptable salt thereof to a subject in need thereof. 2. The method of claim 1 , wherein R1 claim 1 , R1 claim 1 , R2 and R3 are independently selected from the group consisting of H claim 1 , unsubstituted or substituted (C1-C6) alkyl claim 1 , (C1-C4) alkoxy claim 1 , (C6-C12) aryloxy claim 1 , and unsubstituted or substituted (C6-C12) aryl.3. The method of claim 1 , wherein R3 is halo or halo substituted straight or branched (C1-C6) alkyl.4. The method of claim 1 , wherein R1 and R2 are independently selected from the group consisting of five or six-membered N-heterocycle and benzoheterocycle.5. The method of claim 1 , wherein R1 claim 1 , R2 and R3 are independently (C1-C4) alkyl.6. The method of claim 1 , wherein R1 claim 1 , R2 and R3 are independently selected from the group consisting of phenylmethoxyl claim 1 , phenylethoxyl or phenylpropoxyl.7. The method of claim 1 , wherein R1 and R2 are independently selected from the group consisting of phenyl claim 1 , chlorobenzene claim 1 , phenol or aniline.8. The method of claim 1 , wherein the compound is selected from the group consisting of benzyl 7-(4-hydroxy-3-methoxyphenyl)-5-methyl-4 claim 1 ,7-dihydrotetrazolo[1 claim 1 ,5-a]pyrimidine-6-carboxylate claim 1 , 7-(4-hydroxy-3-methoxylphenyl)-5-methyl-6-carboxylic acid benzyl ester-4 claim 1 ,7-dihydrotetrazolo[1 claim 1 ,5-α]pyrimidine; 7-(3 claim 1 ,4-diethoxylphenyl)-6-[N-(2-methoxylphenyl)methanamide]-5-methyl-4 claim 1 ,7-dihydrotetrazolo[1 claim 1 ,5-α]pyrimidine; 7-(4-phenylmethoxyl-3-methoxylphenyl)-6-(N-phenyl methanamide)-5-methyl-4 claim 1 ,7-dihydrotetrazolo[1 claim 1 ,5-α]pyrimidine; 7-(2-N-pyrimidine)-5-fluor-6- ...
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