Ground rack spraying production line

The invention aims to provide a ground rack spraying production line. The ground rack spraying production line comprises a rack, a ground rack conveying line and a plurality of spraying chambers, wherein the ground rack conveying line circulates around the plane on which the rack is mounted; the plurality of spraying chambers are distributed on the ground rack conveying line, and are internally provided with leveling and curing furnaces; the front end of the spraying chamber at the frontmost end is provided with a water fall dust removing cabinet and a drying device; the rear end of the spraying chamber at the tail end is provided with an electrostatic dust removing device; and the curing furnaces are provided with air supply systems. The ground rack spraying production line provided by the invention has the beneficial effects that a to-be-sprayed article is subjected to vanish spraying by the spraying chamber at the frontmost end, subjected to colored paint spraying through a painting ...

Q-switched laser device for improving output stability

The invention relates to a Q-switched laser device for improving output stability, and belongs to the technical field of laser. The laser device at least comprises a pumping source, a pump driving system, a laser gain medium, a saturable absorber and a cavity mirror. By a polarized light pumping technology and a gain pre-pumping technology, the stability, such as polarization characteristic stability, amplitude stability and repetition frequency stability, of an output pulse is improved. The Q-switched laser device for improving the output stability has the advantages that the device is simple, effective, easy to adjust, reliable in working stability, wide in application range and the like, and the problems that the output polarization direction of the traditional Q-switched laser device is unstable, and the amplitude stability and the repetition frequency stability of the output pulse are reduced along with the increasing of repetition frequency are solved.

Polarization Q-switched laser device for improving quality of output light beam

The invention relates to a polarization Q-switched laser device for improving quality of an output light beam, and belongs to the technical field of laser. The laser device comprises a pumping source, a laser gain medium, a saturable absorber with absorbing anisotropy and dynamic diaphragm characteristic, and an endoscope. By a polarized light pump, the polarized output of the Q-switched laser device is realized by using the absorbing anisotropy and the dynamic diaphragm characteristic of the saturable absorber, and the quality of the output light beam is improved. The polarization Q-switched laser device for improving the quality of the output light beam has the advantages that the device is simple, effective, easy to adjust, reliable in working stability, high in practicability and wide in application range, and the problems that the output polarization direction of the traditional Q-switched laser device is unstable, and the quality of the output light beam is low are solved.

Pulsed laser for improving output polarization property

The invention relates to a pulsed laser for improving output polarization property, belonging to the technical field of laser. The laser at least comprises a pumping source, a laser gain medium, a saturable absorption component and an endoscope. By changing an unpolarized pumping method coupled by optical fibers of the traditional semiconductor laser and adopting a polarized light pumping method to implement the linear polarization output of the pulsed laser, the stability of the output polarization direction is improved. According to the pulsed laser, as no polarization control component needs to be inserted into a cavity of the laser, the insertion loss due to the traditional technology is eliminated; the pulsed laser has the advantages of simple structure, easiness in adjustment and stable and reliable working; and the problems that the output polarization direction of the traditional pulsed laser is too instable to affect the nonlinear frequency conversion and the laser power amplification ...

Modified Host Cells and Uses Thereof

The present disclosure provides compositions and methods comprising cells producing glycoproteins with variant glycosylation patterns. The methods and compositions may be used in producing antibodies and proteins of therapeutic value. 117-. (canceled)18. An N-linked glycan comprising one glucose molecule , four mannose molecules , and two N-acetylglycosamine molecules.19. The N-linked glycan of claim 18 , wherein glucose is located at a terminal end of N-linked glycan claim 18 , and wherein N-linked glycan optionally comprises one or more fucose molecules.2221. An isolated glycoprotein that contains an N-glycan of any one of -.23. The glycoprotein of wherein glycoprotein is an enzyme.24. The glycoprotein of wherein glycoprotein is an antibody.25. The glycoprotein of wherein N-linked glycan is attached to an Fc region of antibody.26. The glycoprotein of wherein antibody binds to a cancer antigen.27. The glycoprotein of wherein cancer antigen is selected from group consisting of HER2 claim 26 , Immunoglobulin epsilon Fc receptor II claim 26 , Alk-1 claim 26 , CD20 claim 26 , EGF receptor claim 26 , VEGF receptor claim 26 , FGF receptor claim 26 , NGF receptor claim 26 , PDGF receptor claim 26 , EpCam claim 26 , CD3 claim 26 , CD4 claim 26 , CD11a claim 26 , CD19 claim 26 , CD22 claim 26 , CD30 claim 26 , CD33 claim 26 , CD38 claim 26 , CD40 claim 26 , CD51 claim 26 , CD55 claim 26 , CD80 claim 26 , CD95 claim 26 , CCR2 claim 26 , CCR3 claim 26 , CCR4 claim 26 , CCR5 claim 26 , CTLA-4 claim 26 , Mucin 1 claim 26 , Mucin 16 claim 26 , Endoglin claim 26 , Mesolin receptor claim 26 , Nogo receptor claim 26 , folate receptor claim 26 , CXCR4 claim 26 , insulin-like growth factor receptor claim 26 , Ganglioside GD3 claim 26 , and alpha and beta Integrins.28. The glycoprotein of wherein antibody is produced by a modified host cell which produces a substantially homogeneous population of N-linked glycans.29. The glycoprotein of wherein antibody has an increased ADCC (antibody ...

Method for Manufacturing Heat Dissipation Bulk of Semiconductor Device

A method for manufacturing a heat dissipation bulk of a semiconductor device including the following steps is described. An electrically conductive layer is formed to cover a surface of a temporary substrate. At least one semiconductor chip is connected to the electrically conductive layer by at least one metal bump, wherein the at least one metal bump is located between the at least one semiconductor chip and the electrically conductive layer. A metal substrate is formed on the electrically conductive layer, wherein the metal substrate fills up a gap between the at least one semiconductor chip and the electrically conductive layer. The temporary substrate is removed.

Devices and Methods for Two Step Searches for Servers by a Communication Device

Disclosed are a communication device and a method of a communication device that includes processing by the controller a first scan for shared drives and folders on a wide local area network in accordance with a CIFS Protocol and then processing a second scan for shared drives and folders of a local wide area network in accordance with an Address Resolution Protocol. An Address Resolution Protocol (ARP) is a computer network host's link layer or hardware address when only it's Internet Layer (IP) or Network Layer address is known. An ARP port scan is a low level request and answer protocol that uses a simple message format that contains one address resolution request or response. IP addresses are the result of an ARP port scan. In this way, user can be provided with the opportunity to connect to all available local servers. 1. A method of a communication device having a controller , a memory , display and a transceiver , the method comprising:processing by the controller a first scan for shared drives and folders on a local network in accordance with a Common Internet File System Protocol;transmitting a first scan signal via the transceiver;processing by the controller a second scan for shared drives and folders of a local network in accordance with an Address Resolution Protocol; andtransmitting a second scan signal via the transceiver.2. The method of claim 1 , further comprising:receiving a response to the second scan via the transceiver;displaying on the display a user notification of a response to the second scan.3. The method of claim 2 , wherein displaying on the display a user notification of a response to the second scan comprises:displaying an IP address of the device with an available shared drive or folder.4. The method of claim 2 , wherein receiving a response to the second scan via the transceiver comprises:receiving an IP address; andwherein the method further comprises:determining a host name from the IP address.5. The method of claim 4 , wherein ...

ABERRATION-CORRECTING DARK-FIELD ELECTRON MICROSCOPY

A transmission electron microscope includes an electron beam source to generate an electron beam. Beam optics are provided to converge the electron beam. An aberration corrector comprising either a foil or a set of concentric elements corrects the electron beam for at least a spherical aberration. A specimen holder is provided to hold a specimen in the path of the electron beam. A detector is used to detect the electron beam transmitted through the specimen. The transmission electron microscope may be configured to operate in a dark-field mode in which a zero beam of the electron beam is not detected. The microscope may also be capable of operating in an incoherent illumination mode. 1. A transmission electron microscope comprising:an electron beam source to generate an electron beam;beam optics to converge the electron beam, the beam optics defining an optic axis of the microscope along which there is substantial cylindrical symmetry of the beam optics;an aberration corrector comprising a foil located approximately at the optic axis, the aberration corrector being adapted to correct the electron beam for at least a spherical aberration;a specimen holder to hold a specimen in the path of the electron beam; anda detector to detect the electron beam transmitted through the specimen.2. The transmission electron microscope of claim 1 , wherein the foil comprises a conductive grid claim 1 , the conductive grid comprising a metal.3. The transmission electron microscope of claim 2 , wherein the conductive grid has a thickness of from about 0.1 nm to about 10 nm.4. The transmission electron microscope of claim 1 , wherein the foil comprises a material that changes at least one dimension in relation to temperature claim 1 , and further comprising a temperature applicator to change the temperature of the foil to induce a change in an electric field created by the foil.5. The transmission electron microscope of claim 1 , wherein the foil comprises (i) two metal layers and (ii) ...

Scanning Transmission Electron Microscopy for Polymer Sequencing

A scanning transmission electron microscope includes an electron beam source to generate an electron beam. Beam optics are provided to converge the electron beam to a probe, such as a longitudinally stretched probe. A stage is provided to hold a specimen in the path of the electron beam. The specimen comprises one or more polymers to be sequenced. A beam scanner scans the electron beam across the specimen. A controller may define one or more scanning areas corresponding to the locations of the polymers, and control one or more of the beam scanner and stage to selectively scan the electron beam probe in the scanning areas. The controller may also tune the beam optics during imaging. One or more detectors are provided to detect electrons transmitted through the specimen to generate an image for each of the scanning areas. The controller may also analyze the one or more images to sequence the polymers. 1. A scanning transmission electron microscope for imaging a specimen , the microscope comprising:an electron beam source to generate an electron beam;beam optics to converge the electron beam into a longitudinally stretched probe;a stage to hold a specimen in the path of the electron beam probe;a beam scanner to scan the electron beam probe across the specimen;a detector to detect electrons transmitted through the specimen to generate an image; anda controller to analyze the image to determine information regarding the specimen.2. The scanning transmission electron microscope of claim 1 , wherein the specimen comprises an elongated object claim 1 , and wherein the controller is adapted to control the microscope to selectively scan the electron beam substantially along the elongated object of the specimen.3. The scanning transmission electron microscope of claim 1 , wherein the specimen comprises an elongated object claim 1 , and wherein the controller is adapted to control the stage to selectively move the stage such that the electron beam is scanned substantially along ...

INCOHERENT TRANSMISSION ELECTRON MICROSCOPY

A transmission electron microscope includes an electron beam source to generate an electron beam. Beam optics are provided to converge the electron beam. An aberration corrector corrects the electron beam for at least a spherical aberration. A specimen holder is provided to hold a specimen in the path of the electron beam. A detector is used to detect the electron beam transmitted through the specimen. The transmission electron microscope may operate in an incoherent mode and may be used to locate a sequence of objects on a molecule. 1. A transmission electron microscope comprising:an electron beam source to generate an electron beam;beam optics to converge the electron beam;a specimen holder to hold a specimen in the path of the electron beam; anda detector to detect the electron beam transmitted through the specimen,wherein the transmission electron microscope is adapted to generate electron beams that are incoherent in relation to one another at different times to operate in an incoherent mode.2. The transmission electron microscope of claim 1 , wherein the transmission electron microscope is adapted to alter the energy of the electron beam source.3. The transmission electron microscope of claim 2 , wherein the transmission electron microscope is adapted to scan a focus of the electron beam simultaneously that the energy of the electron beam source is altered.4. The transmission electron microscope of claim 1 , wherein the beam optics comprise an objective lens having an aperture claim 1 , and wherein the transmission electron microscope is adapted to rock or scan the electron beam within the angular range that is collected by the aperture of the objective lens.5. The transmission electron microscope of claim 1 , further comprising a tilting prism to alternately flip the electron beam between two mirror angles.6. A transmission electron microscope comprising:an electron beam source to generate an electron beam;beam optics to converge the electron beam, the beam ...

OPTICAL STRUCTURE AND LIGHT EMITTING DEVICE

A light emitting device includes a substrate, a light emitting unit, and a first optical structure. The light emitting unit is disposed on a top surface of the substrate. The first optical structure is disposed on the light emitting unit. The first optical structure includes a plurality of first nanostructures and a plurality of first quantum dot units. Each of the first quantum dot units is disposed in the first nanostructure. The light emitting unit is used to generate a first color light. Each of the first quantum dot units is used to be excited by the first color light to generate a second color light different from the first color light. 1. A light emitting device , comprising:a substrate, having a top surface and a bottom surface;a light emitting unit, disposed on the top surface of the substrate; and a plurality of first nanostructures; and', 'a plurality of first quantum dot units, disposed in the first nanostructures,', 'wherein the light emitting unit is used to generate a first color light, and each of the first quantum dot units is used to be excited by the first color light to generate a second color light different from the first color light., 'a first optical structure, disposed on the light emitting unit, the first optical structure comprises2. The light emitting device of claim 1 , wherein the first optical structure further comprises a plurality of second quantum dot units disposed in the first nanostructures claim 1 , and each of the second quantum dot units is used to be excited by the first color light to generate a third color light different from the first color light and the second color light.3. The light emitting device of claim 1 , wherein the substrate further comprises:a plurality of second nanostructures; anda plurality of third quantum dot units and a plurality of fourth quantum dot units, respectively disposed in different second nanostructures,wherein each of the third quantum dot units is used to be excited by the first color light ...

METHOD FOR INHIBITING CANCER METASTASIS BY AMIODARONE

Amiodarone inhibits the invagination during zebrafish heart development and makes the defect on valves development. The present invention demonstrates that Amiodarone inhibits cancer metastasis and provides a method for inhibiting cancer metastasis in a subject in need thereof comprising administering to the subject a pharmaceutically effective amount of an Amiodarone or its salt. 1. A method for inhibiting cancer metastasis in a subject in need thereof comprising administering to the subject a pharmaceutically effective amount of an Amiodarone or its salt.2. The method of claim 1 , wherein the salt is hydrochloride.3. The method of claim 1 , wherein the cancer is selected from cancer cells with an increased expression of Versican V1 or an Amiodarone inducible expression of Versican V2.4. The method of claim 3 , wherein the cancer is selected from cancer cells with an abnormal expression of EGFR.5. The method of claim 1 , wherein the inhibition of cancer metastasis is due to an inhibition of epithelial-mesenchymal transition of the cancer by the Amiodarone.6. The method of claim 5 , wherein the inhibition of epithelial-mesenchymal transition is through an inhibition of EGFR signaling pathway by the Amiodarone. The present invention is related to a method for inhibiting cancer metastasis by Amiodarone or its salt.Amiodarone is categorized as a type III antiarrhythmic drug. It is considered a broad-spectrum antiarrhythmic agent because it has multiple and complex effects on the electrical activity of the heart. As such, Amiodarone is effective in treating tachyarrhymias, including re-entry supraventricular tachycardias, ventricular tachycardia, atrial arrhythmias and ventricular fibrillation. While Amiodarone is considered the antiarrhythmic treatment of choice, it is classified as a category D drug. Consequently, caution should be exercised before using Amiodarone for pregnant women, as it causes embryonic hypothyroidism and hyperthyroidism. In contrast, it is showed ...

TOUCH STEREOSCOPIC DISPLAY DEVICE

A touch stereoscopic display device includes a display panel, a touch panel, and a parallax barrier. The display panel has a display surface. The touch panel is disposed on a side of the display surface. The touch panel includes a cover lens and a touch sensing unit. The cover lens has a touch side and a non-touch side opposite to the touch side. The non-touch side faces the display panel. The touch sensing unit is disposed on the non-touch side of the cover lens. The parallax barrier is disposed in the touch panel, and the parallax barrier is used to generate a barrier stereoscopic display effect. The parallax barrier is disposed on the non-touch side of the cover lens. 1. A touch stereoscopic display device , comprising:a display panel, having a display surface; a cover lens, having a touch side and a non-touch side opposite to the touch side, wherein the non-touch side faces the display panel; and', 'a touch sensing unit, disposed on the non-touch side of the cover lens; and, 'a touch panel, disposed on a side of the display panel, wherein the touch panel comprisesa parallax barrier, disposed in the touch panel and being used to generate a barrier stereoscopic display effect, wherein the parallax barrier is disposed on the non-touch side of the cover lens.2. The touch stereoscopic display device according to claim 1 , wherein the touch panel further comprises a planarization layer disposed between the parallax barrier and the touch sensing unit claim 1 , and the parallax barrier claim 1 , the planarization layer and the touch sensing unit are stacked with one another along a direction perpendicular to the cover lens.3. The touch stereoscopic display device according to claim 2 , wherein the planarization layer directly contacts with the parallax barrier and the touch sensing unit.4. The touch stereoscopic display device according to claim 2 , wherein the parallax barrier is disposed between the planarization layer and the cover lens claim 2 , and the touch ...

Scanning Transmission Electron Microscopy for Imaging Extended Areas

A scanning transmission electron microscope for imaging a specimen includes an electron beam source to generate an electron beam. Beam optics are provided to converge the electron beam. A stage is provided to hold a specimen in the path of the electron beam. A beam scanner scans the electron beam across the specimen. A controller may define one or more scanning areas corresponding to locations of the specimen, and control one or more of the beam scanner and stage to selectively scan the electron beam in the scanning areas. A detector is provided to detect electrons transmitted through the specimen to generate an image. The controller may generate a sub-image for each of the scanning areas, and stitch together the sub-images for the scanning areas to generate a stitched-together image. The controller may also analyze the stitched-together image to determine information regarding the specimen.

NAKED EYE TYPE AND GLASSES TYPE SWITCHABLE STEREOSCOPIC DISPLAY DEVICE

A naked eye type and glasses type switchable stereoscopic display device includes a display panel and a switching module. The display panel provides first display image and second display image. The switching module includes a first transparent electrode, a second transparent electrode, a liquid crystal layer, and an electric field uniforming layer. The electric field uniforming layer is disposed between the liquid crystal layer and the second transparent electrode. The liquid crystal layer is driven by the second transparent electrode through the electric field uniforming layer to form liquid crystal lenses under a naked eye type stereoscopic display mode; the switching module provides a first phase retardation mode and a second phase retardation mode under a glasses type display mode. The first phase retardation mode provides a first polarization state to the first display image; the second phase retardation mode provides a second polarization state to the second display image. 1. A naked eye type and glasses type switchable stereoscopic display device , comprising:a display panel, having a display surface, wherein the display panel is used to provide a first display image and a second display image; and a first transparent substrate, having a first inner side and a first outer side;', 'a second transparent substrate, disposed oppositely to the first transparent substrate, wherein the second transparent substrate has a second inner side and a second outer side, and the second inner side faces the first inner side;', 'a first transparent electrode, disposed between the first transparent substrate and the second transparent substrate;', 'a second transparent electrode, disposed between the first transparent electrode and the second transparent substrate;', 'a liquid crystal layer, disposed between the first transparent electrode and the second transparent electrode, wherein the liquid crystal layer comprises a plurality of liquid crystal molecules; and', 'an ...

ORGANIC LIGHT-EMITTING DIODE PACKAGE STRUCTURE AND METHOD OF MANUFACTURING CONCAVITY ON SUBSTRATE

The present invention provides an organic light-emitting diode package structure including a first substrate, a second substrate, at least an organic light-emitting diode device and a dam. The first substrate and a surface of the second substrate are disposed opposite to each other, wherein the surface of the second substrate includes a plurality of concavities, each of the concavities has an opening area, and a ratio of a sum of the opening areas of the concavities to an area of the first surface of the second substrate is substantially between 0 and 1. The organic light-emitting diode device is disposed on the first substrate, and a light emitting surface of the organic light-emitting diode device faces the second substrate. The dam is disposed between the first substrate and the second substrate to combine the first substrate and the second substrate, and the dam surrounds the organic light-emitting diode device. 1. An organic light-emitting diode package structure , comprising:a first substrate;a second substrate having a first surface and a second surface, and the first surface of the second substrate and the first substrate being disposed opposite to each other, wherein the first surface of the second substrate comprises a plurality of concavities, each of the concavities has an opening area, and a ratio of a sum of the opening areas of the concavities to an area of the first surface of the second substrate is substantially between 0 and 1;at least an organic light-emitting diode device, disposed on the first substrate, wherein a light emitting surface of the organic light-emitting diode device faces the second substrate; anda dam, disposed between the first substrate and the second substrate to combine the first substrate and the second substrate, wherein the dam surrounds the organic light-emitting diode device.2. The organic light-emitting diode package structure according to claim 1 , wherein the first substrate claim 1 , the second substrate claim 1 , the ...

ANTI-ROR1 ANTIBODIES

The invention relates to antibodies, and in particular, to antibodies exhibiting specificity for Receptor tyrosine kinase-like Orphan Receptors (ROR), and to uses thereof, for example in the treatment of cancer. The invention extends to polynucleotide and polypeptide sequences encoding the antibodies, and therapeutic uses thereof, and to diagnostic kits comprising these molecules. The invention also extends to antibody-drug conjugates and to uses thereof in therapy. 144.-. (canceled)45. A polypeptide capable of binding to Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) protein , the peptide comprising an amino acid sequence selected from a group consisting of:(i) SEQ ID NO:8, 9, 10, 16, 17 and/or 18;(ii) SEQ ID NO:24, 25, 26, 32, 33 and/or 34;(iii) SEQ ID NO:40, 41, 42, 48, 49 and/or 50;(iv) SEQ ID NO:56, 57, 58, 64, 65 and/or 66;(v) SEQ ID NO:72, 73, 74, 80, 81 and/or 82;(vi) SEQ ID NO:88, 89, 90, 96, 97 and/or 98;(vii) SEQ ID NO:104, 105, 106, 112, 113 and/or 114;(viii) SEQ ID NO:120, 121, 122, 128, 129 and/or 130;(ix) SEQ ID NO:136, 137, 138, 144, 145 and/or 146;(x) SEQ ID NO:152, 153, 154, 160, 161 and/or 162;(xi) SEQ ID NO:168, 169, 170, 176, 177 and/or 178;(xii) SEQ ID NO:184, 185, 186, 192, 193 and/or 194;(xiii) SEQ ID NO:200, 201, 202, 208, 209 and/or 210; and/or(xiv) SEQ ID NO:216, 217, 218, 224, 225 and/or 226.46. The polypeptide of claim 45 , comprising a functional fragment of an anti-ROR1 antibody.47. The polypeptide of claim 46 , comprising an anti-ROR1 scFv.48. The polypeptide of claim 45 , comprising at least two claim 45 , three claim 45 , four claim 45 , five or six amino acid sequences defined in any of (i) to (xiv).49. The polypeptide according to claim 45 , wherein the peptide comprises an amino acid sequence substantially as set out in SEQ ID NO: 4 claim 45 , 20 claim 45 , 36 claim 45 , 52 claim 45 , 68 claim 45 , 84 claim 45 , 100 claim 45 , 116 claim 45 , 132 claim 45 , 148 claim 45 , 164 claim 45 , 180 claim 45 , 196 or 212 claim 45 , ...

Antibody/t-cell receptor chimeric constructs and uses thereof

The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.

POLLUTION-FREE ELECTROPLATING SOLUTION FOR ELECTROPLATING AND PREPARATION METHOD THEREOF

This disclosure discloses a pollution-free electroplating solution for electroplating and its preparation method. The process of the preparation method includes: mixing choline chloride with nitrogenous compounds in molar ratio of 1:2, heating to 80° C. to form uniform ionic liquid, adding metal chloride into ionic liquid with molar concentration between 0.005M to 0.5 M, adding 7˜11 wt % of bio bacteria and 0.7M˜2M of inorganic acid agent into the mixed liquid. After been mixed thoroughly, this pollution-free electroplating solution is ready for the application in electroplating. 1. A pollution-free electroplating solution for an electroplating process , comprising:a choline chloride;a nitrogenous compound, mixed with the choline chloride and heated to 80° C. to form an ionic liquid, wherein the molar concentration ratio between the choline chloride and nitrogenous is 1:2;a metal chloride, which is added into the ionic liquid, wherein molar concentration of the metal chloride in the ionic liquid ranges between 0.005M to 0.5M;a bio bacteria, which is added into the ionic liquid, wherein the weight fraction of the bio bacteria in the ionic liquid between 7 wt % to 11 wt %; andan inorganic acid agent, which is added into the ionic liquid, wherein molar concentration of the inorganic acid agent in the ionic liquid ranges between 0.7M to 2M.2. The pollution-free electroplating solution of claim 1 , further comprising a saccharin added into the ionic liquid claim 1 , wherein the molar concentration of the saccharin in the ionic liquid is between 0.05M to 0.2M.3. The pollution-free electroplating solution of claim 1 , wherein the nitrogenous compound is selected from ammonia claim 1 , urea or uric acid.4. The pollution-free electroplating solution of claim 1 , wherein the metal chloride is selected from nickel chloride claim 1 , copper chloride claim 1 , cobalt chloride claim 1 , zinc chloride claim 1 , gold chloride or silver chloride.5. The pollution-free electroplating ...

ANTI-KIR3DL1 ANTIBODIES

The disclosure provides antibody agents that bind to inhibitory human killer immunoglobulin-like receptors (KIRs). Particular antibody agents of the disclosure include antibody agents that bind to KIR3DL1 (also known as CD158e). Also provided are related nucleic acids, vectors, compositions and methods of using KIR-binding antibody agents of the present technology. 19.-. (canceled)10. An antibody or antigen binding fragment thereof comprising:(a) a heavy chain CDR1 sequence comprising SEQ ID NO:23, a heavy chain CDR2 sequence comprising SEQ ID NO:24, a heavy chain CDR3 sequence comprising SEQ ID NO:25, a light chain CDR1 sequence comprising SEQ ID NO:20, a light chain CDR2 sequence comprising SEQ ID NO:21, and a light chain CDR3 sequence comprising SEQ ID NO:22;(b) a heavy chain CDR1 sequence comprising SEQ ID NO:29, a heavy chain CDR2 sequence comprising SEQ ID NO:30, a heavy chain CDR3 sequence comprising SEQ ID NO:31, a light chain CDR1 sequence comprising SEQ ID NO:26, a light chain CDR2 sequence comprising SEQ ID NO:27 and a light chain CDR3 sequence comprising SEQ ID NO:28;(c) a heavy chain CDR1 sequence comprising SEQ ID NO:35, a heavy chain CDR2 sequence comprising SEQ ID NO:36, a heavy chain CDR3 sequence comprising SEQ ID NO:37, a light chain CDR1 sequence comprising SEQ ID NO: 32, a light chain CDR2 sequence comprising SEQ ID NO:33 and a light chain CDR3 sequence comprising SEQ ID NO:34;(d) a heavy chain CDR1 sequence comprising SEQ ID NO:41, a heavy chain CDR2 sequence comprising SEQ ID NO:42, a heavy chain CDR3 sequence comprising SEQ ID NO:43; a light chain CDR1 sequence comprising SEQ ID NO:38, a light chain CDR2 sequence comprising SEQ ID NO:39 and a light chain CDR3 sequence comprising SEQ ID NO:40;(e) a heavy chain CDR1 sequence comprising SEQ ID NO:47, a heavy chain CDR2 sequence comprising SEQ ID NO:48, a heavy chain CDR3 sequence comprising SEQ ID NO:49, a light chain CDR1 sequence comprising SEQ ID NO:44, a light chain CDR2 sequence comprising ...

DISPLAY DEVICE AND DRIVING METHOD OF DISPLAY DEVICE

A display device for a user to observe a stereo image through a pair of polarization glasses includes a projector, a switchable polarizer, and a sensor. The projector sequentially displays a first image, a first middle image, a second image, and a second middle image on a projection screen. The switchable polarizer is located between the projector and the projection screen and is switchable between a first mode and a second mode, so that each of the first and second images has a first or second polarization after passing through the switchable polarizer in the first or second mode and is then projected onto the projection screen. The sensor is coupled to the switchable polarizer and senses the images on the projection screen. When the sensor senses the first middle image or the second middle image, the switchable polarizer switches between the first mode and the second mode. 1. A display device for a user seeing an image displayed by the display device through a pair of polarization glasses to obtain a stereo image , the display device comprising:a projector sequentially displaying a first image, a first middle image, a second image, and a second middle image on a projection screen;a switchable polarizer located between the projection screen and the projector, the switchable polarizer being switchable between a first mode and a second mode, such that each of a light of the first image and another light of the second image has a first polarization state or a second polarization state after passing through the switchable polarizer in the first mode or the second mode and is projected onto the projection screen; anda sensor coupled to the switchable polarizer, the sensor sensing the images on the projection screen, wherein when the sensor senses the first middle image or the second middle image, the switchable polarizer switches from one of the first mode and the second mode to the other.2. The display device as recited in claim 1 , wherein the switchable polarizer ...

GENERATION OF A CAPTCHA ON A HANDHELD TOUCH SCREEN DEVICE

Embodiments of the present disclosure relate to a CAPTCHA generation method. According to the method, a request for accessing a resource is received from a handheld touch screen device. A default virtual keyboard type is received from the handheld touch screen device. In response to the request, a CAPTCHA is generated based on the default virtual keyboard type. The CAPTCHA is sent to the handheld touch screen device. 1. A CAPTCHA generation method , comprising:receiving, by a server, a request to access a resource from a handheld touch screen device, the request including a default virtual keyboard type of the handheld touch screen device;the server generating a CAPTCHA based on the default virtual keyboard type; andthe server transmitting the generated CAPTCHA to the handheld touch screen device.2. The CAPTCHA generation method of claim 1 , further comprising:the handheld touch screen device displaying the CAPTCHA.3. The CAPTCHA generation method of claim 1 , wherein the CAPTCHA comprises at least one of the following:in response to the default virtual keyboard type being an alphabet virtual keyboard, the CAPTCHA comprises only alphabets;in response to the default virtual keyboard type being a numeric virtual keyboard, the CAPTCHA comprises only numbers;in response to the default virtual keyboard type being a scratchable-latex virtual keyboard, the CAPTCHA comprises only alphabets, wherein any adjacent alphabets of the CAPTCHA are not on a same key button of the scratchable-latex virtual keyboard; andin response to the default virtual keyboard type being a full-size virtual keyboard, CAPTCHA comprises random alphabets and numbers.4. The CAPTCHA generation method of claim 1 , further comprising:in response to the handheld touch screen device detecting a new virtual keyboard type changed from the default virtual keyboard type, the handheld touch screen device sending the new virtual keyboard type to the server.5. The CAPTCHA generation method of claim 4 , further ...

ALPHA-TRUXILLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF

The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, said compound having the structure: Formula (I) 3. The compound of claim 1 , wherein when one of Ror Ris —C(═O)OH and R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , Rand Rare each H claim 1 , then the other of Ror Ris other than —C(═O)ORwhere Ris tolyl claim 1 , 1-naphthalene or 2-naphthalene claim 1 , or —C(═O)O-alkyl-Rwhere the alkyl is a branched Calkyl and the Ris phenyl.4. The compound of claim 1 , wherein when one of Ror Ris —C(═O)OH and the other of Ror Ris —C(═O)ORwhere Ris 1-naphthalene or 2-naphthalene claim 1 , then one of R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , Rand Ris other than —H; or{'sub': 1', '2', '1', '2', '13', '13', '3', '4', '5', '6', '7', '8', '9', '10', '11', '12, 'wherein when one of Ror Ris —C(═O)OH and the other of Ror Ris —C(═O)ORwhere Ris 1-naphthalene or 2-naphthalene, then two of R, R, R, R, R, R, R, R, Rand Ris other than —H; or'}{'sub': 1', '2', '1', '2', '13', '13', '3', '4', '5', '6', '7', '8', '9', '10', '11', '12, 'herein when one of Ror Ris —C(═O)OH and the other of Ror Ris —C(═O)ORwhere Ris 1-naphthalene or 2-naphthalene, then four of R, R, R, R, R, R, R, R, Rand Ris other than —H.'}56.-. (canceled)7. The compound of claim 1 ,wherein{'sub': 1', '2', '13, 'claim-text': {'sub': '13', 'wherein Ris cycloalkyl, aryl or heteroaryl; and'}, 'one of Ror Ris —C(═O)OR,'}{'sub': 1', '2, 'the other of Ror Ris —C(═O)OH.'}8. The compound of claim 1 ,wherein{'sub': 1', '2', '14, 'claim-text': {'sub': 14', '3, 'wherein Ris CF, cycloalkyl, aryl or heteroaryl; and'}, 'one of Ror Ris —C(═O)O-alkyl-R,'}{'sub': 1', '2, 'the other of Ror Ris —C(═O)OH.'}910.-. (canceled)117. The compound of claim 1 , wherein the aryl or heteroaryl is a substituted aryl or heteroaryl claim 1 , wherein ...

GM HYBRIDOMA CELL, MONOCLONAL ANTIBODY, KIT AND PREPARATION METHOD AND USE THEREOF

The present invention provides a hybridoma cell under the accession number CGMCC No. 13827. The hybridoma cell is capable of producing a monoclonal antibody against galactomannan antigen and a kit is prepared using the same. The kit provided by the present invention can specifically bind to the GM antigen, has both sensitivity and specificity of more than 95%, a detection limit of 0.85 ng/mL compared to 1 ng/mL of the existing product, and high compliance rate between the detection result and the reference reagent, and can provide more accurate and reliable detection results, so that IA can be detected early in the course of the disease and the patients can receive treatment in timely and effective manner, thereby improving the survival rate of patients. Moreover, the kit has simple and convenient operation, rapid and sensitive detection, which provides an effective tool for the quantitative detection of GM antigen. 1. A hybridoma cell or a passage cell thereof having an accession number of CGMCC No. 13827.2Aspergillus. A monoclonal antibody or a specific antigen-binding fragment thereof claim 1 , wherein the monoclonal antibody is produced by the hybridoma cell of claim 1 , and the specific antigen-binding fragment is capable of specifically binding to galactomannan antigen.3. The monoclonal antibody or specific antigen-binding fragment thereof of claim 2 , wherein the specific antigen-binding fragment is selected from the group consisting of (Fab′)2 claim 2 , Fab claim 2 , Fv claim 2 , scFv claim 2 , diabody claim 2 , linear antibody or multispecific antibody.4. A detection reagent comprising the monoclonal antibody or specific antigen-binding fragment thereof of .5. The detection reagent of claim 4 , wherein the specific antigen-binding fragment is selected from the group consisting of (Fab′)2 claim 4 , Fab claim 4 , Fv claim 4 , scFv claim 4 , diabody claim 4 , linear antibody or multispecific antibody.6. A detection kit comprising the monoclonal antibody or ...

PCB Board Plug Mechanism, Finished Board, and Subrack

An embodiment of the present invention discloses a PCB board plug mechanism configured to implement hot plug of a PCB board, and including an output end that moves along a second direction when the input end moves. The second direction is at an angle with the first direction. The connector for connecting the to-be-plugged PCB board is disposed at the output end. In a process in which the output end moves along the second direction, the PCB board can be driven to perform a corresponding hot plug action. 1. A PCB board plug mechanism comprisingan input end that moves along a first direction under an external force and an output end that moves along a second direction when the input end moves, wherein the second direction is at an angle with the first direction, wherein the second direction is a plug direction of the PCB board; anda connector for connecting the PCB board is disposed at the output end, wherein in a process in which the output end moves along the second direction, the connector drives the PCB board to perform a corresponding hot plug action.2. The PCB board plug mechanism according to claim 1 , comprising:a tie bar, wherein a first guiding mechanism is disposed on the tie bar, one end of the tie bar forms the input end, an extended guiding direction of the first guiding mechanism is perpendicular to the plug direction of the to-be-plugged PCB board, and the extended guiding direction of the first guiding mechanism is the first direction;a swing rod, wherein one end of the swing rod is hinge-connected to the other end of the tie bar by using a first hinge, and the other end of the swing rod forms the output end; anda position limiting rod, wherein one end of the position limiting rod is hinge-connected to the swing rod by using a second hinge, the other end of the position limiting rod forms an installation end by using a first fastening pin, and a distance between the first hinge and the second hinge, a distance between the second hinge and the output ...

LED Meshwork Lamp and Production Method Thereof

The present disclosure discloses an LED meshwork lamp and a production method thereof. The LED meshwork lamp includes: at least two LED string lights which are arranged in parallel along a lateral direction, the LED string light including a first conducting wire, a second conducting wire, a third conducting wire, a plurality of SMD LEDs and a plurality of encapsulation colloids; at least two auxiliary wires, the at least two auxiliary wires and the at least two LED string lights being arranged alternately one by one in parallel and spaced apart along the lateral direction; and a plurality of connecting members configured to interlace the plurality of lamp beads of each LED string light with two auxiliary wires on both sides of the LED string light to form a meshwork structure. 1. An LED meshwork lamp , comprising:at least two LED string lights arranged in parallel along a lateral direction, wherein, each LED string light comprises a first conducting wire, a second conducting wire, a third conducting wire, a plurality of Surface Mounted Devices (SMD) LEDs and a plurality of encapsulation colloids; the first conducting wire, the second conducting wire and the third conducting wire are arranged in parallel along a lateral direction or intertwisted together; the first conducting wire, the second conducting wire and the third conducting wire all include a conducting wire core and an insulation layer covering a surface of the conducting wire core; the insulation layer on the first conducting wire is removed at intervals of a predetermined length along an axial direction of the first conducting wire to form a plurality of first welding spots, the insulation layer on the second wire is removed at intervals of the predetermined length along an axial direction of the second conducting wire to form a plurality of second welding spots; positions of the plurality of the second welding spots correspond to positions of the plurality of the first welding spots one to one to form a ...

Electrodeless Surface-Mounted LED String Light, Method and Apparatus for Manufacturing the Same

An electrodeless surface-mounted LED string light, a method and an apparatus for manufacturing the same are disclosed. The electrodeless surface-mounted LED string light includes: a first wire and a second wire; a plurality of LED units, wherein each LED units includes two surface-mounted LEDs, and luminous surfaces of the two surface-mounted LEDs are opposite to each other, and the luminous surfaces of the two surface-mounted LEDs are parallel to an axial direction of the first and second wires; and a plurality of encapsulants respectively encapsulating the two surface-mounted LEDs of the plurality of LED units therein. 1. An electrodeless surface-mounted LED string light , comprising:a first wire and a second wire arranged side by side or intertwisted with each other, wherein each of the first wire and the second wire comprises a wire core and an insulating layer covered on a surface of the wire core, a plurality of first welding spots are formed by stripping the insulating layer of the first wire at a set interval along an axial direction thereof, a plurality of second welding spots are formed by stripping the insulating layer of the second wire at a set interval along an axial direction thereof, and wherein positions of the plurality of the second welding spots are in one-to-one correspondence with positions of the plurality of the first welding spots so as to form a plurality of welding light regions;a plurality of LED units disposed at the plurality of welding light regions, respectively, wherein each LED unit comprises a first surface-mounted LED and a second surface-mounted LED, and wherein a luminous surface of the first surface-mounted LED is opposite to a luminous surface of the second surface-mounted LED, the luminous surface of the first surface-mounted LED faces an upper side of the welding light regions, the luminous surface of the second surface-mounted LED faces a lower side of the welding light regions, positions of positive electrodes and negative ...

Electrodeless Side-Mounted LED String Light, Method and Apparatus for Manufacturing the Same

An electrodeless side-mounted LED string light, a method and an apparatus for manufacturing the same are provided by the disclosure. The electrodeless side-mounted LED string light includes: a first wire and a second wire, a plurality of LED units and a plurality of encapsulants. Each LED unit includes a first surface-mounted LED and a second surface-mounted LED. Luminous surfaces of the first and second surface-mounted LEDs are opposite to each other. The luminous surfaces of the first and second surface-mounted LEDs are perpendicular to an axial direction of the first and second wires. The plurality of encapsulants respectively encapsulants the first and second surface-mounted LEDs therein. With the electrodeless side-mounted LED string light of the disclosure, the utilization rate of the lighting wire of the string light is improved, the utilization rates of raw materials and apparatus are improved, the product quality and manufacturing efficiency are improved.

LED Light String Ornament and Method for Manufacturing the Same

The present disclosure discloses an LED light string ornament and a method for producing the same. The LED light string ornament includes an LED light string and a plurality of decorative pieces. The LED light string includes three wires, a plurality of SMD LEDs, and a plurality of adhesive bodies. A part or a whole of the decorative piece are transparent or semi-transparent. The decorative piece includes a first housing and a second housing. The first housing and the second housing are buckled to form an accommodating cavity, and a plurality of LED beads of the LED light string are respectively accommodated in the accommodating cavities of the plurality of decorative pieces. 1. An LED light string ornament , comprising:a Light-Emitting Diode (LED) light string, comprising at least three wires, a plurality of Surface Mounted Device (SMD) LEDs, and a plurality of packaging adhesive bodies, wherein the at least three wires are arranged side by side or twisted together; the wire comprises a wire core and an insulating layer covering a surface of the wire core; at least two of the at least three wires are formed with a plurality of pairs of opposed solder joints by removing the insulating layer thereof in an axial direction thereof at an interval of a set length; each solder foot of the plurality of SMD LEDs is soldered to each solder joint of the plurality of pairs of the solder joints respectively to connect the plurality of SMD LEDs in parallel, in series or in a hybrid connection, and the plurality of packaging adhesive bodies are respectively wrapped on surfaces of the plurality of SMD LEDs to form a plurality of LED beads; anda plurality of decorative pieces, wherein a part or a whole of the decorative piece is transparent or semi-transparent; the decorative piece comprises a first housing and a second housing; the first housing and the second housing are buckled to form an accommodating cavity; the plurality of LED beads of the LED light string are respectively ...

LED String Light, and Production Method and Device Thereof

An LED string light includes: a first conducting wire, a second conducting wire, a third conducting wire arranged in parallel, insulation layers of the first and second conducting wires are removed at intervals of the predetermined length along axial direction of the conducting wire to form a plurality of first and second welding spots; a plurality of SMD LEDs respectively disposed at the plurality of lamp welding regions, two welding legs of each SMD LED being respectively welded onto a first welding spot and a second welding spot at one corresponding lamp welding region, the plurality of the SMD LEDs being connected in series, in parallel or in hybrid; and a plurality of encapsulation colloids respectively coating the plurality of the SMD LEDs and surfaces of portions of the third conducting wire corresponding to positions of the plurality of the SMD LEDs, to form a plurality of lamp beads. 1. An LED string light , comprising:a first conducting wire, a second conducting wire, a third conducting wire which are arranged in parallel; wherein the first conducting wire, the second conducting wire and the third conducting wire all comprise a conducting wire core and an insulation layer coating a surface of the conducting wire core; the insulation layer of the first conducting wire is removed at intervals of a predetermined length along an axial direction of the first conducting wire to form a plurality of first welding spots, the insulation layer of the second conducting wire is removed at intervals of the predetermined length along an axial direction of the second conducting wire to form a plurality of second welding spots, positions of the first welding spots respectively correspond to positions of the second welding spots one to one, to form a plurality of lamp welding regions;a plurality of Surface Mounted Devices (SMD) LEDs respectively disposed at the plurality of lamp welding regions, two welding legs of each SMD LED being respectively welded onto a first welding ...

LED Hose Lamp, and Production Method and Device Thereof

An LED hose lamp includes: an LED string light including a first conducting wire, a second conducting wire, a third conducting wire, a plurality of SMD LEDs and a plurality of encapsulation colloids, wherein a plurality of first and second welding spots are formed by removing insulation layers of the first and second conducting wire at intervals of a predetermined distance along axial directions of the first and second conducting wires respectively, two welding legs of each SMD LED are respectively welded onto a first welding spot and a second welding spot, the plurality of encapsulation colloids respectively coat the plurality of SMD LEDs and surfaces of portions of the third conducting wire corresponding to positions of the plurality of the SMD LEDs; and a soft tube coating outside the first conducting wire, the second conducting wire, the third conducting wire and the encapsulation colloid through an injection molding. 1. An LED hose lamp , comprising:an LED string light comprising a first conducting wire, a second conducting wire, a third conducting wire, a plurality of Surface Mounted Devices (SMD) LEDs and a plurality of encapsulation colloids; wherein the first conducting wire, the second conducting wire and the third conducting wire are arranged in parallel or intertwisted with each other; the first conducting wire, the second conducting wire and the third conducting wire all comprise a conducting wire core and an insulation layer covering a surface of the conducting wire core; the insulation layer of the first conducting wire is removed at intervals of a predetermined distance along an axial direction of the first conducting wire to form a plurality of first welding spots, the insulation layer of the second conducting wire is removed at intervals of the predetermined distance along an axial direction of the second conducting wire to form a plurality of second welding spots, positions of the first welding spots respectively correspond to positions of the ...

2d and 3d switchable display device and liquid crystal lenticular lens thereof

A liquid crystal lenticular lens includes a first transparent substrate, a second transparent substrate, a first transparent electrode, a second transparent electrode, a liquid crystal layer, a first alignment layer, a second alignment layer and a first electric field uniformizing layer. The first transparent electrode includes a plurality of first electrode bars disposed along a first direction and in parallel, and the first direction is non-parallel and non-perpendicular to the edges of the first transparent substrate. The first electric field uniformizing layer is disposed between the first alignment layer and the first transparent electrode or between the second alignment layer and the second transparent electrode.

APPROXIMATE NAMED-ENTITY EXTRACTION

According to one embodiment, approximate named-entity extraction from a dictionary that includes entries is provided, where each of the entries includes one or more words. Words are read from the entries of the dictionary, and network resources are searched to determine a frequency of occurrence of the words on the network resources. In view of the frequency of occurrence of the words located on the network resources, domain relevancy of the words in the entries of the dictionary is determined. A domain repository is created using top-ranked words as determined by the domain relevancy of the words. In view of the domain repository, signatures for both the entries of the dictionary and strings of an input document are computed. The strings of the input document are filtered by comparing the signatures of the strings against the signatures of the entries to identify approximate-match entity names. 17-. (canceled)8. A computer program product for approximate named-entity extraction from a dictionary comprising a plurality of entries , each of the entries including one or more words , the computer program product comprising a computer readable storage medium having computer readable program code embodied therewith , the computer readable program code being executable by a computer to perform a method comprising:reading a plurality of the words from the entries of the dictionary;searching network resources to determine a frequency of occurrence of the words on the network resources;in view of the frequency of occurrence of the words located on the network resources, determining domain relevancy of the words in the entries of the dictionary;creating a domain repository using top-ranked words as determined by the domain relevancy of the words;in view of the domain repository, computing signatures for both the entries of the dictionary and strings of an input document; andfiltering the strings of the input document by comparing the signatures of the strings against the ...

Approximate named-entity extraction

According to one embodiment, a method is provided for approximate named-entity extraction from a dictionary that includes entries, where each of the entries includes one or more words. Words are read from the entries of the dictionary, and network resources are searched to determine a frequency of occurrence of the words on the network resources. In view of the frequency of occurrence of the words located on the network resources, domain relevancy of the words in the entries of the dictionary is determined. A domain repository is created using top-ranked words as determined by the domain relevancy of the words. In view of the domain repository, signatures for both the entries of the dictionary and strings of an input document are computed. The strings of the input document are filtered by comparing the signatures of the strings against the signatures of the entries to identify approximate-match entity names.

ANTIBODY/T-CELL RECEPTOR CHIMERIC CONSTRUCTS AND USES THEREOF

The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs. 1. An antibody-T cell receptor (TCR) chimeric molecule (abTCR) that specifically binds to a target antigen , comprising:{'sub': H', 'H, 'a) a first polypeptide chain comprising a first antigen-binding domain comprising Vand C1 antibody domains and a first T cell receptor domain (TCRD) comprising a first transmembrane domain of a first TCR subunit; and'}{'sub': L', 'L, 'b) a second polypeptide chain comprising a second antigen-binding domain comprising Vand Cantibody domains and a second TCRD comprising a second transmembrane domain of a second TCR subunit,'}{'sub': H', 'H', 'L', 'L, 'wherein the Vand C1 domains of the first antigen-binding domain and the Vand Cdomains of the second antigen-binding domain form an antigen-binding module that specifically binds to the target antigen,'}wherein the first TCRD and the second TCRD form a T cell receptor module (TCRM) that is capable of recruiting at least one TCR-associated signaling module, andwherein i) the first TCR subunit is a TCR γ chain, and the second TCR subunit is a TCR δ chain, or ii) the first TCR subunit is a TCR δ chain, and the second TCR subunit is a TCR γ chain.2. The abTCR of claim 1 , wherein the first TCR subunit is a TCR γ chain claim 1 , and the second TCR subunit is a TCR δ chain.3. The abTCR of claim 1 , wherein the first TCR subunit is a TCR δ chain claim 1 , and the second TCR subunit is a TCR γ chain.4. The abTCR of claim 1 , wherein the first polypeptide chain further comprises a first peptide linker between the first antigen-binding domain and the first TCRD and the second polypeptide chain further comprises a second peptide linker between the second antigen-binding domain and the second TCRD.5. The abTCR of ...

T CELL RECEPTOR-LIKE ANTIBODIES SPECIFIC FOR A WTI PEPTIDE PRESENTED BY HLA-A2

The present invention provides antigen binding proteins that specifically bind to Wilms' tumor protein (WT1), including humanized, chimeric and fully human antibodies against WT1, antibody fragments, chimeric antigen receptors (CARs), fusion proteins, and conjugates thereof. The antigen binding proteins and antibodies bind to HLA-A0201-restricted WT1 peptide. Such antibodies, fragments, fusion proteins and conjugates thereof are useful for the treatment of WT1 associated cancers, including for example, breast cancer, ovarian cancer, prostate cancer, chronic myelocytic leukemia, multiple myeloma, acute lymphoblastic leukemia (ALL), acute myeloid/myelogenous leukemia (AML) and myelodysplastic syndrome (MDS). In more particular embodiments, the anti-WT1/A antibodies may comprise one or more framework region amino acid substitutions designed to improve protein stability, antibody binding and/or expression levels. 1. An isolated antibody , or antigen-binding fragment thereof , comprising one of: (ii) a heavy chain (HC) variable region comprising HC-CDR1, HC-CDR2 and HC-CDR3 respectively, comprising amino acid sequences SEQ ID NOS: 20, 21 and 22; and a light chain (LC) variable region comprising LC-CDR1, LC-CDR2 and LC-CDR3 respectively, comprising amino acid sequences SEQ ID NOS: 26, 27 and 28;', '(iii) a heavy chain (HC) variable region comprising HC-CDR1, HC-CDR2 and HC-CDR3 respectively, comprising amino acid sequences SEQ ID NOS: 38, 39 and 40; and a light chain (LC) variable region comprising LC-CDR1, LC-CDR2 and LC-CDR3 respectively, comprising amino acid sequences selected from SEQ ID NOS: 44, 45 and 46;', '(iv) a heavy chain (HC) variable region comprising HC-CDR1, HC-CDR2 and HC-CDR3 respectively, comprising amino acid sequences SEQ ID NOS: 56, 57 and 58; and a light chain (LC) variable region comprising LC-CDR1, LC-CDR2 and LC-CDR3 respectively, comprising amino acid sequences SEQ ID NOS: 62, 63 and 64;', '(v) a heavy chain (HC) variable region comprising HC- ...

ELECTROPLATING APPARATUS

An apparatus for electroplating which is applicable to the electroplating of workpiece is disclosed. The apparatus includes: an electroplating solution container, a target, an absorbent piece, and a power supply. All the electroplating solution, workpiece, absorbent piece, and target are placed inside the electroplating solution container with at least partial portions of each workpiece, absorbent piece and target submerged in the electroplating solution. The positive electrode of the power supply is electrically connected to the target while its negative electrode is electrically connected to the workpiece and absorbent piece simultaneously. When the power supply imposes a current through the circuit, the target releases metal ions into the electroplating solution and metal ions reduce and a metal coating is formed on the workpiece. In the meantime, carbocations in the electroplating solution are adsorbed on the absorbent piece. 1. An electroplating apparatus , applicable to a workpiece to be electroplated , comprising:an electroplating container, which contains an electroplating solution and the workpiece to be electroplated at least partially submerged in the electroplating solution;a target, which is made of conductive material and is contained in the electroplating container with at least partial submersion in the electroplating solution;an absorbent piece, which is contained in the electroplating container with at least partial submersion in the electroplating solution; anda power supply, which is equipped with a positive electrode and a negative electrode, connected electrically to the target and the workpiece, respectively;when the power supply imposes an operating current, the target dissolves metal ions into the electroplating solution, the metal ions reduce into metal atoms and a coating is formed on the surface of the workpiece to be electroplated, and the absorbent piece adsorbs the carbocations in the electroplating solution.2. The electroplating ...

OPTICAL FIBER, AND SYSTEM AND METHOD FOR MANUFACTURING OPTICAL FIBER

An optical fiber comprises, from a center to a periphery, a fiber core of undoped silica; a cladding layer; and a coating of polyacrylate, wherein the fiber core has a radius of 5 to 7 μm and an ellipticity of less than 1.5%, the cladding layer with an ellipticity of less than 0.4% comprises inner, intermediate, and outer cladding layers, the inner cladding layer being doped with fluorine of 5 to 12 μm thickness, and refractive index difference to fiber core of −0.4 to −0.2%, the outer cladding layer being undoped quartz of 25 to 45 μm thickness, and the coating comprises an inner coating of 25 to 40 μm thickness, and an outer coating of 25 to 35 μm thickness and an ellipticity of less than 2%. The optical fiber has high durability and large effective transmission area, a method and system for preparing such optical fiber are also disclosed. 1. An optical fiber comprises , from a center to a periphery of the optical fiber , a fiber core; a cladding layer; and a coating , whereinthe fiber core is an undoped silica glass, with a radius of 5 μm to 7 μm, ellipticity of the fiber core being less than 1.5%,the cladding layer comprises an inner cladding layer, an intermediate cladding layer, and an outer cladding layer, the inner cladding layer being doped with fluorine, having, a thickness of 5 μm to 12 μm, a relative refractive index difference between the inner cladding layer and the fiber core being −0.4% to −0.2%,the intermediate cladding layer having a thickness of 12 μm to 25 μm, the outer cladding layer being a pure quartz glass layer with a thickness of 25 μm to 45 μm, and an overall ellipticity of the cladding layer being less than 0.4%, andthe coating is made of polyacrylate, and comprises an inner coating and an outer coating the inner coating having, a thickness of 25 μm to 40 μm, and the outer coating having a thickness of 25 μm to 35 μm, and an ellipticity of the outer coating being less than 2%.2. The optical fiber of claim 1 , wherein the optical fiber has ...

IMAGE PROCESSING METHOD AND DEVICE FOR PANORAMA IMAGE

The present disclosure discloses a processing method and device for a panorama image. The processing method includes the following steps: A panorama image is converted a cubemap format. Under the cubemap format, a depth information image of the panorama image is calculated, and a seamless processing is performed on the depth information image. The format of the depth information image is converted to the original format from the cubemap format to obtain the depth information image corresponding to the panorama image. 1. A processing device for a panorama image , comprising:a processing unit; obtain a first image;', 'convert the first image with a first format to a second image with a cubemap format;', 'duplicate two vertical view angle blocks of the second image to respectively generate three duplicate blocks and connect a plurality of horizontal view angle blocks of the second image not connected to the two vertical view angle blocks to the duplicate blocks by a corresponding connection side between each of the horizontal view angle blocks and each of the duplicate blocks to generate a third image;', 'obtain two images with a size of 3×3 blocks from the third image to generate a fourth image and a fifth image;', 'calculate the depth information of the fourth image and the depth information of the fifth image to generate a first depth information image corresponding to the fourth image and a second depth information image corresponding to the fifth image;', 'perform a first blending processing on the overlapping areas of the first depth information image and the overlapping areas of the second depth information image according to two overlapping areas of the first depth information image corresponding to two block groups of the fourth image and two overlapping areas of the second depth information image corresponding to two block groups of the fifth image;', 'obtain a plurality of portions corresponding to the blocks of the second image from the first depth ...

LED String Light, and Production Method and Device Thereof

An LED string light includes: a first conducting wire, a second conducting wire, a third conducting wire arranged in parallel, insulation layers of the first and second conducting wires are removed at intervals of the predetermined length along axial direction of the conducting wire to form a plurality of first and second welding spots; a plurality of SMD LEDs respectively disposed at the plurality of lamp welding regions, two welding legs of each SMD LED being respectively welded onto a first welding spot and a second welding spot at one corresponding lamp welding region, the plurality of the SMD LEDs being connected in series, in parallel or in hybrid; and a plurality of encapsulation colloids respectively coating the plurality of the SMD LEDs and surfaces of portions of the third conducting wire corresponding to positions of the plurality of the SMD LEDs, to form a plurality of lamp beads. 1. An LED string light , comprising:a first conducting wire, a second conducting wire, a third conducting wire which are arranged in parallel; wherein the first conducting wire, the second conducting wire and the third conducting wire all comprise a conducting wire core and an insulation layer coating a surface of the conducting wire core; the insulation layer of the first conducting wire is removed at intervals of a predetermined length along an axial direction of the first conducting wire to form a plurality of first welding spots, the insulation layer of the second conducting wire is removed at intervals of the predetermined length along an axial direction of the second conducting wire to form a plurality of second welding spots, positions of the first welding spots respectively correspond to positions of the second welding spots one to one, to form a plurality of lamp welding regions;a plurality of Surface Mounted Devices (SMD) LEDs respectively disposed at the plurality of lamp welding regions, two welding legs of each SMD LED being respectively welded onto a first welding ...

UNSUPERVISED INFORMATION EXTRACTION DICTIONARY CREATION

A data handling system enables the unsupervised creation of an information extraction dictionary by expanding upon a word or phrase included within an expansion query. Prior to receiving the expansion query, the data handling system performs an unsupervised learning of an information corpus which includes text to assign a corpus vector to each word and phrase of the text. After the expansion query, the data handling system compares the expansion query to the corpus vectors. The data handling system ranks the corpus vectors by similarity to the expansion query and provides a ranked list of words or phrases associated with the ranked corpus vectors. The ranked list may be subsequently utilized as the information extraction dictionary. 1. A method of performing an unsupervised learning of text within an information corpus to generate a vector representation of every word or phrase of the text of the information corpus , the method comprising:prior to a host device receiving an expansion query from a client device, assigning, with the host device, a corpus vector to each word and phrase within an information corpus stored within a data source local to the host system;forming, with the host device, a plurality of clusters, each cluster comprising a plurality of similar corpus vectors; andindicating, with the host device, a particular corpus vector within each cluster as being a representative corpus vector of the cluster in which the particular corpus vector resides.2. The method of claim 1 , wherein each corpus vector is at least a machine readable representation of a part of speech of an associated word or phrase within the information corpus.3. The method of claim 1 , wherein each corpus vector is at least a machine readable representation of a syntax derived definition of an associated word or phrase within the information corpus.4. The method of claim 1 , wherein each corpus vector is at least a machine readable representation of a semantic derived definition of an ...

UNSUPERVISED INFORMATION EXTRACTION DICTIONARY CREATION

A data handling system enables the unsupervised creation of an information extraction dictionary by expanding upon a word or phrase included within an expansion query. Prior to receiving the expansion query, the data handling system performs an unsupervised learning of an information corpus which includes text to assign a corpus vector to each word and phrase of the text. After the expansion query, the data handling system compares the expansion query to the corpus vectors. The data handling system ranks the corpus vectors by similarity to the expansion query and provides a ranked list of words or phrases associated with the ranked corpus vectors. The ranked list may be subsequently utilized as the information extraction dictionary. 1. A method of forming a list of expanded words or phrases generated by an unsupervised learning of text within an information corpus , the method comprising: assigning, with the host device, a corpus vector to each word and phrase within an information corpus stored within a data source local to the host system;', 'forming, with the host device, a plurality of clusters, each cluster comprising a plurality of similar corpus vectors; and', 'indicating, with the host device, a particular corpus vector within each cluster as being a representative corpus vector of the cluster in which the particular corpus vector resides; and, 'prior to a host device receiving an expansion query from a client device assigning, with the host device, a query vector to the expansion query;', 'determining, with the host device, a most similar cluster to the query vector;', 'ranking, with the host device, the corpus vectors within the most similar cluster based upon the similarity to the query vector; and', 'forming, with the host device, a list of words or phrases associated with each of the ranked corpus vectors within the most similar cluster., 'subsequent to the host device receiving the expansion query from the client device2. The method of claim 1 , ...

ANTIBODY/T-CELL RECEPTOR CHIMERIC CONSTRUCTS AND USES THEREOF

The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs. 1. An antibody-T cell receptor (TCR) chimeric molecule (abTCR) that specifically binds to a target antigen , comprising:{'sub': 'H', 'a) a first polypeptide chain comprising a first antigen-binding domain comprising a Vantibody domain and a first T cell receptor domain (TCRD) comprising a first transmembrane domain of a first TCR subunit; and'}{'sub': 'L', 'b) a second polypeptide chain comprising a second antigen-binding domain comprising a Vantibody domains and a second TCRD comprising a second transmembrane domain of a second TCR subunit,'}{'sub': H', 'L, 'wherein the Vdomain of the first antigen-binding domain and the Vdomain of the second antigen-binding domain form an antigen-binding module that specifically binds to the target antigen,'}wherein the first TCRD and the second TCRD form a T cell receptor module (TCRM) that is capable of recruiting at least one TCR-associated signaling module, andwherein the target antigen is a complex comprising a peptide and an MHC protein.2. The abTCR of claim 1 , wherein the first polypeptide chain further comprises a first peptide linker between the first antigen-binding domain and the first TCRD claim 1 , and the second polypeptide chain further comprises a second peptide linker between the second antigen-binding domain and the second TCRD.3. The abTCR of claim 2 , wherein the first and/or second peptide linkers comprise claim 2 , individually claim 2 , a constant domain or fragment thereof from an immunoglobulin or T cell receptor subunit.4. The abTCR of claim 3 , wherein the first and/or second peptide linkers comprise claim 3 , individually claim 3 , a CH1 claim 3 , CH2 claim 3 , CH3 claim 3 , CH4 or CL antibody domain claim 3 , or a ...

T CELL RECEPTOR-LIKE ANTIBODY AGENTS SPECIFIC FOR EBV LATENT MEMBRANE PROTEIN 2A PEPTIDE PRESENTED BY HUMAN HLA

Described herein are antibodies, fragments thereof and multi-specific binding agents that bind an Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2) peptide presented by HLA class I molecules, in particular, HLA-A02. Also provided herein are methods of using the same or compositions thereof for the detection, prevention and/or therapeutic treatment of diseases characterized by expression of an EBV-LMP2 peptide presented by HLA-A02, in particular, Burkit's lymphoma, Hodgkin's lymphoma and nasopharyngeal carcinoma. 1. A human antibody agent that binds an EBV-LMP2/HLA peptide complex , wherein the human antibody agent comprises:(a) a heavy chain variable region having a sequence at least 95% identical to a heavy chain variable region sequence as set forth in any one of SEQ ID NOs: 5, 9, 13, 17, 21, 25, and 29, and(b) a light chain variable region having a sequence at least 95% identical to a light chain variable region sequence as set forth in any one of SEQ ID NOs: 3, 7, 11, 15, 19, 23, and 27.2. The human antibody agent of claim 1 , wherein the human antibody agent has a Kof about 2.0 to about 170 nM.3. The human antibody agent of claim 1 , wherein the EBV-LMP2/HLA peptide complex comprises an EBV-LMP2 peptide that has an amino acid sequence that is or comprises CLGGLLTMV (SEQ ID NO: 1).4. The human antibody agent of claim 3 , wherein the human antibody agent interacts directly with amino acid residues at one or more positions selected from the group consisting of position 1 claim 3 , position 5 claim 3 , position 8 claim 3 , and combinations thereof claim 3 , in the EBV-LMP2 peptide.513.-. (canceled)14. The human antibody agent of claim 1 , wherein the human antibody agent is a human monoclonal antibody or a fragment thereof.15. The human antibody agent of claim 14 , wherein the human monoclonal antibody is an IgG1.16. The human antibody agent of claim 14 , wherein the human monoclonal antibody fragment is an scFv.17. An isolated nucleic acid molecule ...

Anti-ROR2 Antibodies

The invention relates to antibodies, and in particular, to antibodies exhibiting specificity for Receptor tyrosine kinase-like Orphan Receptors (ROR), and to uses thereof for example in the treatment of cancer. The invention extends to polynucleotide and polypeptide sequences encoding the antibodies, and therapeutic uses thereof, and to diagnostic kits comprising these molecules. The invention also extends to antibody-drug conjugates and to uses thereof in therapy.

T CELL RECEPTOR-LIKE ANTIBODIES SPECIFIC FOR A WTI PEPTIDE PRESENTED BY HLA-A2

The present invention provides antigen binding proteins that specifically bind to Wilms' tumor protein (WT1), including humanized, chimeric and fully human antibodies against WT1, antibody fragments, chimeric antigen receptors (CARs), fusion proteins, and conjugates thereof. The antigen binding proteins and antibodies bind to HLA-A0201-restricted WT1 peptide. Such antibodies, fragments, fusion proteins and conjugates thereof are useful for the treatment of WT1 associated cancers, including for example, breast cancer, ovarian cancer, prostate cancer, chronic myelocytic leukemia, multiple myeloma, acute lymphoblastic leukemia (ALL), acute myeloid/myelogenous leukemia (AML) and myelodysplastic syndrome (MDS). In more particular embodiments, the anti-WT1/A antibodies may comprise one or more framework region amino acid substitutions designed to improve protein stability, antibody binding and/or expression levels. 1. An isolated antibody , or antigen-binding fragment thereof , comprising one of: (ii) a heavy chain (HC) variable region comprising HC-CDR1, HC-CDR2 and HC-CDR3 respectively, comprising amino acid sequences SEQ ID NOS: 20, 21 and 22; and a light chain (LC) variable region comprising LC-CDR1, LC-CDR2 and LC-CDR3 respectively, comprising amino acid sequences SEQ ID NOS: 26, 27 and 28;', '(iii) a heavy chain (HC) variable region comprising HC-CDR1, HC-CDR2 and HC-CDR3 respectively, comprising amino acid sequences SEQ ID NOS: 38, 39 and 40; and a light chain (LC) variable region comprising LC-CDR1, LC-CDR2 and LC-CDR3 respectively, comprising amino acid sequences selected from SEQ ID NOS: 44, 45 and 46;', '(iv) a heavy chain (HC) variable region comprising HC-CDR1, HC-CDR2 and HC-CDR3 respectively, comprising amino acid sequences SEQ ID NOS: 56, 57 and 58; and a light chain (LC) variable region comprising LC-CDR1, LC-CDR2 and LC-CDR3 respectively, comprising amino acid sequences SEQ ID NOS: 62, 63 and 64;', '(v) a heavy chain (HC) variable region comprising HC- ...

ANTI-ROR1 ANTIBODIES

The invention relates to antibodies, and in particular, to antibodies exhibiting specificity for Receptor tyrosine kinase-like Orphan Receptors (ROR), and to uses thereof, for example in the treatment of cancer. The invention extends to polynucleotide and polypeptide sequences encoding the antibodies, and therapeutic uses thereof, and to diagnostic kits comprising these molecules. The invention also extends to antibody-drug conjugates and to uses thereof in therapy. 1. An isolated human anti-Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) antibody or a functional fragment thereof.2. The isolated antibody or functional fragment thereof according to claim 1 , wherein the functional fragment comprises a fragment selected from a group consisting of VH claim 1 , VL claim 1 , Fd claim 1 , Fv claim 1 , Fab claim 1 , Fab′ claim 1 , scFv claim 1 , F(ab′)and Fc fragment.3. The isolated antibody or functional fragment thereof according to claim 1 , wherein the antibody or functional fragment thereof selectively interacts with ROR1 peptide with an affinity constant of approximately 10to 10M claim 1 , preferably 10to 10M claim 1 , even more preferably claim 1 , 10to 10M.4. The isolated antibody or functional fragment thereof according to claim 1 , wherein the antibody or fragment thereof exhibits an IC50 for ROR1 of about 10to 10M.5. The isolated antibody or functional fragment thereof according to claim 1 , wherein the antibody or fragment thereof is capable of mediating killing of ROR1-expressing tumor cells.6. The isolated antibody or functional fragment thereof according to claim 1 , wherein the antibody or fragment thereof is capable of blocking binding of Wnt5a to ROR1 protein.7. The isolated antibody or functional fragment thereof according to claim 1 , wherein the antibody or fragment thereof is capable of blocking Wnt5a ROR1 phosphorylation.8. The isolated antibody or functional fragment thereof according to claim 1 , wherein the antibody or fragment thereof is ...

RECOMMENDATION METHOD AND APPARATUS, AND STORAGE MEDIUM

A recommendation method is provided. In the method, a candidate item to be recommended to a social network user is obtained. The social network user has at least two different types of social relationships. For at least one target social object in each of the at least two different types of social relationships of the social network user, attention of each of the at least one target social object in the respective type of social relationship to the candidate item is determined. According to the attention of each of the at least one target social object in the at least two different types of social relationships to the candidate item, a comprehensive attention of the target social objects of the at least two different types of social relationships to the candidate item is determined. According to the comprehensive attention, whether to recommend the candidate item to the social network user is determined. 1. A recommendation method , comprising:obtaining a candidate item to be recommended to a social network user, the social network user having at least two different types of social relationships;determining, for at least one target social object in each of the at least two different types of social relationships of the social network user, attention of each of the at least one target social object in the respective type of social relationship to the candidate item;determining, by processing circuitry and according to the attention of each of the at least one target social object in the at least two different types of social relationships to the candidate item, a comprehensive attention of the target social objects of the at least two different types of social relationships to the candidate item; anddetermining, according to the comprehensive attention, whether to recommend the candidate item to the social network user.2. The method according to claim 1 , wherein the at least two different types of social relationships includes a group relationship claim 1 , and the ...

T CELL RECEPTOR-LIKE ANTIBODIES SPECIFIC FOR A WTI PEPTIDE PRESENTED BY HLA-A2

The present invention provides antigen binding proteins that specifically bind to Wilms' tumor protein (WT1), including humanized, chimeric and fully human antibodies against WT1, antibody fragments, chimeric antigen receptors (CARs), fusion proteins, and conjugates thereof. The antigen binding proteins and antibodies bind to HLA-A0201-restricted WT1 peptide. Such antibodies, fragments, fusion proteins and conjugates thereof are useful for the treatment of WT1 associated cancers, including for example, breast cancer, ovarian cancer, prostate cancer, chronic myelocytic leukemia, multiple myeloma, acute lymphoblastic leukemia (ALL), acute myeloid/myelogenous leukemia (AML) and myelodysplastic syndrome (MDS). In more particular embodiments, the anti-WT1/A antibodies may comprise one or more framework region amino acid substitutions designed to improve protein stability, antibody binding and/or expression levels. 140-. (canceled)42. A bispecific antibody comprising: (a) a heavy chain (HC) variable region comprising HC-CDR1, HC-CDR2 and HC-CDR3 and HC-CDR3 respectively, comprising amino acid sequences SEQ ID NOS: 2, 3, and 4; and a light chain (LC) variable region comprising LC-CDR1, LC-CDR2 and LC-CDR3 respectively, comprising amino acid sequences SEQ ID NOS: 8, 9 and 10;', '(b) a heavy chain (HC) variable region comprising HC-CDR1, HC-CDR2 and HC-CDR3 respectively, comprising amino acid sequences SEQ ID NOS: 20, 21 and 22; and a light chain (LC) variable region comprising LC-CDR1, LC-CDR2 and LC-CDR3 respectively, comprising amino acid sequences SEQ ID NOS: 26, 27 and 28;', '(c) a heavy chain (HC) variable region comprising HC-CDR1, HC-CDR2 and HC-CDR3 respectively, comprising amino acid sequences SEQ ID NOS: 38, 39 and 40; and a light chain (LC) variable region comprising LC-CDR1, LC-CDR2 and LC-CDR3 respectively, comprising amino acid sequences selected from SEQ ID NOS: 44, 45 and 46;', '(d) a heavy chain (HC) variable region comprising HC-CDR1, HC-CDR2 and HC-CDR3 ...

T CELL RECEPTOR-LIKE ANTIBODIES SPECIFIC FOR A PRAME PEPTIDE

The presently disclosed subject matter provides antigen-binding proteins that specifically bind to Preferentially expressed antigen of melanoma (PRAME), including humanized, chimeric and fully human antibodies against PRAME, antibody fragments (e.g., scFv, Fab and F(ab)), chimeric antigen receptors (CARs), fusion proteins, and conjugates thereof. The antigen-binding proteins and antibodies bind to a PRAME peptide/HLA class I molecule complex. Such antibodies, fragments, fusion proteins and conjugates thereof are useful for the treatment of PRAME associated diseases, including for example, breast cancer, ovarian cancer, melanoma, lung cancer, gastrointestinal cancer, brain tumor, head and neck cancer, renal cancer, myeloma, neuroblastoma, mantle cell lymphoma, chronic myelocytic leukemia, multiple myeloma, acute lymphoblastic leukemia (ALL), acute myeloid/myelogenous leukemia (AML), Non-Hodgkin lymphoma (NHL), and Chronic lymphocytic leukemia (CLL). The antibodies or antigen binding proteins may comprise one or more framework region amino acid substitutions designed to improve protein stability, antibody binding and/or expression levels. 1. An isolated antibody , or an antigen-binding portion thereof , which binds to a PRAME peptide bound to a major histocompatibility complex (MHC) molecule.2. The antibody or antigen-binding portion thereof of claim 1 , wherein the MHC molecule is an HLA molecule.3. The antibody or antigen-binding portion thereof of claim 2 , wherein the HLA molecule is an HLA class I molecule.4. The antibody or antigen-binding portion thereof of claim 3 , wherein the HLA class I molecule is HLA-A.5. The antibody or antigen-binding portion thereof of claim 4 , wherein the HLA-A is HLA-A2.6. The antibody or antigen-binding portion thereof of claim 5 , wherein the HLA-A2 is HLA-A*0201.7. The antibody or antigen-binding portion thereof of claim 1 , wherein the PRAME peptide is selected from the group consisting of PRA(SEQ ID NO: 2) claim 1 , PRA(SEQ ID ...

Alpha-truxillic acid derivatives and pharmaceutical compositions thereof

The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, said compound having the structure: Formula (I)

TEMPERATURE SENSING APPARATUS AND TEMPERATURE SENSING METHOD THEREOF

A temperature sensing apparatus and a temperature sensing method thereof are provided. A current source circuit provides a test current to a temperature sensing load, and the temperature sensing load generates a test voltage in response to the test current. A processing circuit determines a type of the temperature sensing load according to the test voltage, and determines a temperature according to the type of the temperature sensing load and a temperature sensing voltage generated by the temperature sensing load. 1. A temperature sensing apparatus , comprising:a current source circuit, coupled to a sensing voltage input terminal of the temperature sensing apparatus, the sensing voltage input terminal being configured to be coupled to a temperature sensing load, the current source circuit providing a test current to the temperature sensing load, the temperature sensing load generating a test voltage to the sensing voltage input terminal in response to the test current; anda processing circuit, coupled to the current source circuit and the sensing voltage input terminal, determining a type of the temperature sensing load according to the test voltage, and determining a temperature according to the type of the temperature sensing load and a temperature sensing voltage generated by the temperature sensing load,wherein when the temperature sensing load is a thermistor, the processing circuit determines an environmental temperature sensed by the thermistor according to the temperature sensing voltage, and when the temperature sensing load is a temperature sensing diode, the processing circuit determines an environmental temperature sensed by the temperature sensing diode according to the temperature sensing voltage.2. The temperature sensing apparatus according to claim 1 , wherein the temperature sensing load is coupled between the sensing voltage input terminal and a ground claim 1 , and the temperature sensing apparatus further comprises:a reference voltage source, ...

METHOD FOR COMPENSATING DESIGN IMAGE OF WORKPIECE AND SYSTEM FOR PROCESSING DESIGN IMAGE OF WORKPIECE

A method for compensating a design image of a workpiece and a system for processing the design image of the workpiece are disclosed. The method includes the following steps. Obtaining a real image of the workpiece, with the real image having registration holes. Calculating a slope value for each of the registration holes. Determining an amount of interpolation points between each two neighboring registration holes of the registration holes according to the slope value corresponding to each of the registration holes. Obtaining positions of control points in blocks formed by the registration holes. Compensating the design image of the workpiece according to positions of the registration holes, positions of the plurality of interpolation points and the positions of the control points for generating a mapping image. Outputting the mapping image adapted to be mapped onto the workpiece. The system, together with the method, will be introduced. 1. A method for compensating a design image of a workpiece , comprising:obtaining a real image of the workpiece, with the real image having a plurality of registration holes;calculating a slope value for each of the plurality of registration holes;determining an amount of interpolation points between each two neighboring registration holes of the plurality of registration holes according to the slope value corresponding to each of the plurality of registration holes;obtaining positions of a plurality of control points in a plurality of blocks formed by the plurality of registration holes, wherein each of the plurality of blocks is surrounded by first registration holes of the plurality of registration holes, each of the plurality of blocks comprises first control points of the plurality of control points, and an amount of the first control points located in each of the plurality of blocks is associated with an amount of first interpolation points between the first registration holes which surround the block;compensating the design ...

Cloud infrastructure for reducing storage facility code load suspend rate by redundancy check

Provided are techniques for code load processing. While performing code load processing of a set of modules of a same module type, it is determined that a first module in the set of modules is not in an operational state. It is determined that a second module is a redundant module for the first module. In response to determining that the second module is in an operational state and has already completed code update, the code load processing is continued. In response to determining that the second module is in an operational state and has not already completed code update, it is determined whether there is a third redundant module that is in an operational state. In response to determining that there is a third redundant module that is in an operational state, the code load processing is continued.

PROVIDING FAULT TOLERANCE IN A VIRTUALIZED COMPUTING ENVIRONMENT THROUGH A SWAPPING APPROACH

An example method is described to provide fault tolerance in a virtualized computing environment with a first fault domain and a second fault domain. The method may comprise determining whether a first primary virtualized computing instance and a first secondary virtualized computing instance are both in the first fault domain. The method may comprise: in response to determination that the first primary virtualized computing instance and first secondary virtualized computing instance are both in the first fault domain, selecting a second secondary virtualized computing instance from the second fault domain; migrating the first secondary virtualized computing instance from a first host to a second host; and migrating the second secondary virtualized computing instance from the second host to the first host, thereby swapping the first secondary virtualized computing instance in the first fault domain with the second secondary virtualized computing instance in the second fault domain. 1. A method to provide fault tolerance in a virtualized computing environment with a first fault domain and a second fault domain , the method comprising:determining whether a first primary virtualized computing instance and a first secondary virtualized computing instance are both in the first fault domain, wherein the first secondary virtualized computing instance is configured as a backup for the first primary virtualized computing instance and supported by a first host; selecting a second secondary virtualized computing instance from the second fault domain, wherein the second secondary virtualized computing instance is configured as a backup for a second primary virtualized computing instance and supported by a second host;', 'migrating the first secondary virtualized computing instance from the first host to the second host; and', 'migrating the second secondary virtualized computing instance from the second host to the first host, thereby swapping the first secondary virtualized ...

PROVIDING FAULT TOLERANCE IN A VIRTUALIZED COMPUTING ENVIRONMENT THROUGH A MIGRATION APPROACH BASED ON RESOURCE AVAILABILITY

An example method is described to provide fault tolerance in a virtualized computing environment with a first fault domain and a second fault domain. The method may comprise determining whether a primary virtualized computing instance and a secondary virtualized computing instance are both in the first fault domain. The secondary virtualized computing instance may be configured as a backup for the primary virtualized computing instance and supported by a first host. The method may further comprise: in response to determination that the primary virtualized computing instance and secondary virtualized computing instance are both in the first fault domain, selecting, from the second fault domain, a second host based on a resource availability of the second host; and migrating the secondary virtualized computing instance from the first host to the second host, thereby migrating the secondary virtualized computing instance from the first fault domain to the second fault domain. 1. A method to provide fault tolerance in a virtualized computing environment with a first fault domain and a second fault domain , the method comprising:determining whether a primary virtualized computing instance and a secondary virtualized computing instance are both in the first fault domain, wherein the secondary virtualized computing instance is configured as a backup for the primary virtualized computing instance and supported by a first host; selecting, from the second fault domain, a second host based on a resource availability of the second host; and', 'migrating the secondary virtualized computing instance from the first host to the second host, thereby migrating the secondary virtualized computing instance from the first fault domain to the second fault domain., 'in response to determination that the primary virtualized computing instance and secondary virtualized computing instance are both in the first fault domain,'}2. The method of claim 1 , wherein the selecting the second host ...

CLOUD INFRASTRUCTURE FOR REDUCING STORAGE FACILITY CODE LOAD SUSPEND RATE BY REDUNDANCY CHECK

Provided are techniques for code load processing. While performing code load processing of a set of modules of a same module type, it is determined that a first module in the set of modules is not in an operational state. It is determined that a second module is a redundant module for the first module. In response to determining that the second module is in an operational state and has already completed code update, the code load processing is continued. In response to determining that the second module is in an operational state and has not already completed code update, it is determined whether there is a third redundant module that is in an operational state. In response to determining that there is a third redundant module that is in an operational state, the code load processing is continued. 118-. (canceled)19. A method for code load processing in a cloud infrastructure comprising at least one cloud computing node , wherein the cloud computing node includes one or more processors and at least one set of modules , comprising: determining with the one or more processors of the at least one cloud computing node, that a first module in the set of modules is not in an operational state;', determining with the one or more processors of the at least one cloud computing node, that a second module is a redundant module for the first module;', 'in response to determining that the second module is in an operational state and has already completed code update, continuing with the one or more processors of the at least one cloud computing node, the code load processing;', 'in response to determining that the second module is in the operational state and has not already completed code update, determining with the one or more processors of the at least one cloud computing node, whether there is a third module that is another redundant module for the first module and that is in an operational state; and', 'in response to determining that there is the third module that is in ...

SMALL-CALIBER, HIGH-PERFORMANCE BROADBAND RADIATOR

A small-caliber, high-performance broadband radiator allows two unit arms of the first and second group of dipoles to be folded inwards, an included angle of 40°-50° is formed between two unit arms of the first/second groups of dipoles and the first/second unit racks, and the unit arms of the first and second groups of dipoles are arranged linearly at interval while flexural loading sections are provided and also connected by dielectric medium. Hence, the broadband radiator allows significant reduction of the aperture of the broadband radiator, and there is a larger adjustment space for the gap of the radiator array, so the interference of low and high bands is less. This allows for improved performance, thus reducing the configuration size and manufacturing cost of antennas, and creating better industrial benefits with improved applicability. 1. A small-caliber , high-performance broadband radiator comprising: two groups of dipoles set in pair , and equilibrators used to securely support such dipoles; said equilibrators are protruded upwards in an x-frame pattern , comprising of first and second unit racks orthogonally to each other as well as a pedestal used to connect the first and second unit racks; both the first and second groups of dipoles comprise two unit arms and a mating portion located between two unit arms; of which , the first group of dipoles are set at two protruding ends of the first unit racks via the mating portion , while the second group of dipoles are set at two protruding ends of the second unit racks via the mating portion; the broadband radiator characterized in that:two unit arms of the first and second groups of dipoles are folded inwards; an included angle of 40-50° is formed between two unit arms of the first group of dipoles and the first unit racks, while an included angle of 40°-50° is formed between two unit arms of the second group of dipoles and the second unit racks; the unit arms of the first group of dipoles and the unit arms of ...

INCOHERENT TRANSMISSION ELECTRON MICROSCOPY

A transmission electron microscope includes an electron beam source to generate an electron beam. Beam optics are provided to converge the electron beam. A specimen holder is provided to hold a specimen in the path of the electron beam. A detector is used to detect the electron beam transmitted through the specimen. The transmission electron microscope may be adapted to generate two or more images that are substantially incoherently related to one another, store the images, and combine amplitude signals at corresponding pixels of the respective images to improve a signal-to-noise ratio. Alternatively or in addition, the transmission electron microscope may be adapted to operate the specimen holder to move the specimen in relation to the beam optics during exposure or between exposures to operate the transmission electron microscope in an incoherent mode. 1. A transmission electron microscope comprising:an electron beam source to generate an electron beam;beam optics to converge the electron beam;a specimen holder to hold a specimen in the path of the electron beam; anda detector to detect the electron beam transmitted through the specimen,wherein the transmission electron microscope is adapted to generate two or more images that are substantially incoherently related to one another, store the images, and combine amplitude signals at corresponding pixels of the respective images to improve a signal-to-noise ratio.2. The transmission electron microscope of claim 1 , wherein the transmission electron microscope is adapted to consume less than about 800 W of power.3. A method of generating an image of a specimen claim 1 , the method comprising:generate an electron beam;converge the electron beam;hold a specimen in the path of the electron beam;detect the electron beam transmitted through the specimen to generate two or more images that are substantially incoherently related to one another;store the two or more images; andcombine amplitude signals at corresponding pixels ...

MANAGING A CODE LOAD

A system for managing a code load for a storage system is disclosed. The system can include instantiating a code load. The code load can include a first update for a first component and a second update for a second component. The system can include monitoring the operational state of the first and second components in response to instantiating the code load. The system can also include determining to perform the first update in response to a triggering event. The system can also include performing the first update in response to determining to perform the first update. 1. A system for managing a code load for a first storage device and a second storage device , the system comprising a non-transitory computer readable storage medium storing instructions and a processor communicatively coupled to the first storage device , the second storage device , and the computer readable storage medium , wherein the processor is configured to:instantiate a code load, the code load including a first firmware update for the first storage device;monitor, in response to instantiating the code load, an operational state of the first storage device;determine, in response to a triggering event associated with a change in the operational state of the first storage device, to perform the first firmware update; andperform at least the first firmware update in response to determining to perform the first firmware update.2. The system of claim 1 , wherein the code load includes a second firmware update for a second storage device claim 1 , the processor further configured to:monitor a second operational state of the second storage device;determine, within a same time frame as performing the first firmware update, to perform the second firmware update; andperform, in response to determining to perform the second firmware update, the second firmware update.3. The system of claim 1 , the processor further configured to maintain a resource management database in the computer readable storage ...

T cell receptor-like antibodies specific for a wti peptide presented by hla-a2

The present invention provides antigen binding proteins that specifically bind to Wilms' tumor protein (WT1), including humanized, chimeric and fully human antibodies against WT1, antibody fragments, chimeric antigen receptors (CARs), fusion proteins, and conjugates thereof. The antigen binding proteins and antibodies bind to HLA-A0201-restricted WT1 peptide. Such antibodies, fragments, fusion proteins and conjugates thereof are useful for the treatment of WT1 associated cancers, including for example, breast cancer, ovarian cancer, prostate cancer, chronic myelocytic leukemia, multiple myeloma, acute lymphoblastic leukemia (ALL), acute myeloid/myelogenous leukemia (AML) and myelodysplastic syndrome (MDS). In more particular embodiments, the anti-WT1/A antibodies may comprise one or more framework region amino acid substitutions designed to improve protein stability, antibody binding and/or expression levels.

PREPARATION METHOD OF CRYTOCOCCUS NEOFORMANS CAPSULAR POLYSACCHARIDE GXM AS WELL AS GXM ANTIGEN IMMUNOASSAY KIT AND APPLICATION THEREOF

The present invention discloses a preparation method of capsular polysaccharide GXM as well as a GXM antigen immunoassay kit and an application thereof. The preparation method of the capsular polysaccharide GXM effectively avoids the use of a toxic chemical reagent, ensures safety of operators, and also avoids environmental pollution, has high specificity, and can prepare a high-purity capsular polysaccharide while simplifying a preparation process. The GXM antigen immunoassay kit adopts a competition method, has good sensitivity, specificity, repeatability and stability, has high recovery rate of a target compound and may provide more accurate and reliable inspection results. The kit is simple and feasible in use and operation, rapid and sensitive in detection and low in price and provides an effective tool for clinical detection of GXM. 1crytococcus neoformans. A preparation method of capsular polysaccharide GXM , comprising a step of purifying the GXM by utilizing a GXM immunoaffinity chromatography column.2. The preparation method according to claim 1 , wherein the preparation method comprises the following steps:{'i': 'crytococcus neoformans', '(1) performing crude extraction on capsular polysaccharide GXM; and'}{'i': 'crytococcus neoformans', '(2) purifying a crude extract of the capsular polysaccharide GXM by utilizing the GXM immunoaffinity chromatography column.'}3crytococcus neoformans. The preparation method according to claim 2 , wherein the extraction of the capsular polysaccharide GXM comprises the following steps:{'i': 'crytococcus neoformans', '(1) culturing until a bacteria concentration reaches a later logarithmic phase;'}(2) performing autoclaved sterilization on bacterium liquid, centrifuging to remove thalli, and reserving supernatant;(3) adding calcium acetate powder into the supernatant while stirring until the final concentration of the supernatant is 2-8%, and adding glacial acetic acid to regulate the pH value to be 4.6-5.2; and{'i': ' ...

Information recommendation method and apparatus, device, and storage medium

This application discloses an information recommendation method and apparatus, a device, and a storage medium, and belongs to the field of information recommendation. The method includes starting an application program according to a start operation, a first account being logged in in the application program; obtaining a recommended information flow for the first account, recommended information in the recommended information flow including at least one piece of interactive recommended information, the interactive recommended information being information for which a second account generates an interactive message, the first account and the second account having a social relationship; and displaying an information presentation interface, the information presentation interface comprising the recommended information displayed in an information flow form.

Multi-station concurrent testing method, control station and multi-station concurrent testing apparatus

A multi-station concurrent testing method, comprising: a step A in which the control station controls the handler to send SOT signal(s) of corresponding testing station(s) based on previous testing results at adjacent testing stations of the testing stations; a step B in which the control station constructs an SOT signal sequence based on the received SOT signal(s) and in correspondence to orders of the testing stations; and a step C in which the control station compares the SOT signal sequence and an SOT signal prediction value sequence generated by the control station, wherein if the SOT signal sequence and the SOT signal prediction value sequence match, the corresponding testing station(s) executes the test of device(s) under test, and otherwise, the handler is controlled to purge the devices under test at the testing stations, the SOT signal prediction value sequence is generated based on previous testing results at the testing stations.

Antibody/t-cell receptor chimeric constructs and uses thereof

The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.

3D IDENTIFICATION FILTER

A 3D identification filter () is provided, which has a passband partially overlapping with a wavelength range of 800 nm to 1800 nm and a blocking band containing a range of 380 nm to 750 nm, and comprises a substrate () and filter film layers () coated on both surfaces of the substrate, wherein the filter film layer () on one of the surfaces is composed of high refractive index layers, medium refractive index layers, and low refractive index layers that are stacked, and the filter film layer () on the other surface is composed of at least two layers of materials that are stacked. The 3D identification filter () maintains a high bocking level and a narrow transition band while achieving a small wavelength shift at a large light incident angle. 1. A 3D identification filter having a passband partially overlapping with a wavelength range of 800 nm to 1800 nm and a blocking band containing a wavelength range of 380 nm to 750 nm and comprising a substrate and filter film layers coated on both surfaces of the substrate , whereinthe filter film layer on one of the surfaces is composed of high refractive index layers, medium refractive index layers, and low refractive index layers that are stacked; the high refractive index layers are Si:H, and the refractive index of each high refractive index layer at 800 to 1800 nm is greater than 3; the refractive index of each medium refractive index layer at 800 to 1800 nm is greater than 1.6 and less than 3; the refractive index of each low refractive index layer at 800 nm to 1800 nm is less than 1.6; and the ratio of total physical thicknesses of all high refractive index layers and all low refractive index layers is greater than 1.5:1; andthe filter film layer on the other surface is composed of at least two layers of materials that are stacked, and the number of layers is not less than 15; the passband of the filter has a center wavelength that shifts less than 20 nm when the angle of incident light changes from 0 degree to ...

PRIMER PROBE COMBINATION, KIT, DETECTION METHOD AND APPLICATION FOR DETECTING SEPARATE CANDIDA TYPES

The present invention provides a primer probe combination, a kit, a detection method and an application for detecting separate types. The primer probe combination for detecting separate types includes specific primers, detection probes and complementary probes for and The complementary probes and the detection probes are in incomplete complementary pairing. The primer probe combination in the present invention can detect and determine whether infection is caused by in one step and simultaneously distinguish and in the same fluorescence channel. 1CandidaCandida albicans, Candida tropicalis, Candida parapsilosis, Candida kruseiCandida glabrata. A primer probe combination for detecting separate types , comprising specific primers , detection probes and complementary probes specified at and respectively , wherein the complementary probes and the detection probes are in incomplete complementary pairing;{'i': Candida albicans', 'Candida tropicalis', 'Candida parapsilosis', 'Candida krusei', 'Candida, 'nucleotide sequences of the specific primers of the are shown as SEQ ID NO.1-2; nucleotide sequences of the specific primers of the are shown as SEQ ID NO.3-4; nucleotide sequences of the specific primers of the are shown as SEQ ID NO.5-6; nucleotide sequences of the specific primers of the are shown as SEQ ID NO.7-8; and nucleotide sequences of the specific primers of the glabrata are shown as SEQ ID NO.9-10;'}{'i': Candida albicans', 'Candida tropicalis', 'Candida parapsilosis', 'Candida krusei', 'Candida glabrata, 'a nucleotide sequence of the detection probe of the is shown as SEQ ID NO.11; a nucleotide sequence of the detection probe of the is shown as SEQ ID NO.12; a nucleotide sequence of the detection probe of the is shown as SEQ ID NO.13; a nucleotide sequence of the detection probe of the is shown as SEQ ID NO.14; and a nucleotide sequence of the detection probe of the is shown as SEQ ID NO.15;'}{'i': Candida albicans', 'Candida tropicalis', 'Candida parapsilosis', ...

T CELL RECEPTOR-LIKE ANTIBODIES SPECIFIC FOR A WTI PEPTIDE PRESENTED BY HLA-A2

The present invention provides antigen binding proteins that specifically bind to Wilms' tumor protein (WT1), including humanized, chimeric and fully human antibodies against WT1, antibody fragments, chimeric antigen receptors (CARs), fusion proteins, and conjugates thereof. The antigen binding proteins and antibodies bind to HLA-A0201-restricted WT1 peptide. Such antibodies, fragments, fusion proteins and conjugates thereof are useful for the treatment of WT1 associated cancers, including for example, breast cancer, ovarian cancer, prostate cancer, chronic myelocytic leukemia, multiple myeloma, acute lymphoblastic leukemia (ALL), acute myeloid/myelogenous leukemia (AML) and myelodysplastic syndrome (MDS). In more particular embodiments, the anti-WT1/A antibodies may comprise one or more framework region amino acid substitutions designed to improve protein stability, antibody binding and/or expression levels. 1. An isolated antibody , or antigen-binding fragment thereof , comprising one of: (ii) a heavy chain (HC) variable region comprising HC-CDR1, HC-CDR2 and HC-CDR3 respectively, comprising amino acid sequences SEQ ID NOS: 20, 21 and 22; and a light chain (LC) variable region comprising LC-CDR1, LC-CDR2 and LC-CDR3 respectively, comprising amino acid sequences SEQ ID NOS: 26, 27 and 28;', '(iii) a heavy chain (HC) variable region comprising HC-CDR1, HC-CDR2 and HC-CDR3 respectively, comprising amino acid sequences SEQ ID NOS: 38, 39 and 40; and a light chain (LC) variable region comprising LC-CDR1, LC-CDR2 and LC-CDR3 respectively, comprising amino acid sequences selected from SEQ ID NOS: 44, 45 and 46;', '(iv) a heavy chain (HC) variable region comprising HC-CDR1, HC-CDR2 and HC-CDR3 respectively, comprising amino acid sequences SEQ ID NOS: 56, 57 and 58; and a light chain (LC) variable region comprising LC-CDR1, LC-CDR2 and LC-CDR3 respectively, comprising amino acid sequences SEQ ID NOS: 62, 63 and 64;', '(v) a heavy chain (HC) variable region comprising HC- ...

MANAGING A CODE LOAD

A method and system for managing a code load for a storage system is disclosed. The method and system can include instantiating a code load. The code load can include a first update for a first component and a second update for a second component. The method and system can include monitoring the operational state of the first and second components in response to instantiating the code load. The method and system can also include determining to perform the first update in response to a triggering event. The method and system can also include performing the first update in response to determining to perform the first update. 1. A computer implemented method for managing a code load for a storage system comprising:instantiating a code load, the code load including a first firmware update for a first storage device and a second firmware update for a second storage device;monitoring, in response to instantiating the code load, a first operational state of the first storage device;determining, in response to a triggering event, to perform the first firmware update, wherein the triggering event comprises a change in the operational state of the first storage device; andperforming, in response to determining to perform the first firmware update, the first firmware update;analyzing, within the same time frame as performing the first firmware update, an operational state of the second storage device;writing, in response to the analyzing, a recommended action to take regarding the second firmware update for the second storage device; andperforming, in response to performing the first firmware update and writing the recommended action, the recommended action to take regarding the second firmware update for the second storage device.2. (canceled)3. (canceled)4. The method of claim 1 , further comprising maintaining a resource management database that includes information regarding the first operational state claim 1 , wherein the first operational state comprises operational and ...

ANTIBODY/T-CELL RECEPTOR CHIMERIC CONSTRUCTS AND USES THEREOF

The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs. 25-. (canceled)6: The abTCR of claim 1 , wherein the target antigen is a cell surface antigen.78-. (canceled)9: The abTCR of claim 1 , wherein the target antigen is a complex comprising a peptide and a major histocompatibility complex (MEW) protein.1128-. (canceled)29: The abTCR of claim 1 , wherein:(i) the first TCR subunit is a TCR γ chain, and the second TCR subunit is a TCR δ chain; or(ii) the first TCR subunit is a TCR δ chain, and the second TCR subunit is a TCR γ chain.30: The abTCR of claim 10 , wherein:(i) the first TCR subunit is a TCR γ chain, and the second TCR subunit is a TCR δ chain; or(ii) the first TCR subunit is a TCR δ chain, and the second TCR subunit is a TCR γ chain.31: Nucleic acid(s) encoding the first and second polypeptide chains of the abTCR of .32: A complex comprising the abTCR of and at least one TCR-associated signaling module selected from the group consisting of CD3δε claim 1 , CD3γε claim 1 , and ζζ.33. (canceled)34: An effector cell presenting on its surface the abTCR of .35. (canceled)36: The effector cell of claim 34 , wherein the effector cell does not express the first TCR subunit and/or the second TCR subunit.3747-. (canceled)48: A method of killing a target cell presenting a target antigen claim 34 , comprising contacting the target cell with the effector cell of claim 34 , wherein the abTCR specifically binds to the target antigen.5055-. (canceled)56: A pharmaceutical composition comprising the effector cell of claim 34 , and a pharmaceutically acceptable carrier.57: A method of treating a target antigen-associated disease in an individual in need thereof comprising administering to the individual an effective amount of the pharmaceutical ...

T CELL RECEPTOR-LIKE ANTIBODY AGENTS SPECIFIC FOR EBV LATENT MEMBRANE PROTEIN 2A PEPTIDE PRESENTED BY HUMAN HLA

Described herein are antibodies, fragments thereof and multi-specific binding agents that bind an Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2) peptide presented by HLA class I molecules, in particular, HLA-A02. Also provided herein are methods of using the same or compositions thereof for the detection, prevention and/or therapeutic treatment of diseases characterized by expression of an EBV-LMP2 peptide presented by HLA-A02, in particular, Burkit's lymphoma, Hodgkin's lymphoma and nasopharyngeal carcinoma. 1. A human antibody agent that binds an EBV-LMP2/HLA peptide complex , wherein the human antibody agent interacts directly with amino acid residues at one or more positions selected from the group consisting of position 1 , position 5 , position 8 , and combinations thereof , in the EBV-LMP2 peptide.2. The human antibody agent of claim 1 , wherein the human antibody agent has a Kof about 2.0 to about 170 nM.3. The human antibody agent of claim 1 , wherein the EBV-LMP2 peptide has an amino acid sequence that is or comprises CLGGLLTMV (SEQ ID NO:1).4. The human antibody agent of claim 3 , wherein the human antibody agent interacts directly with amino acid residues at one or more positions selected from the group consisting of position 1 claim 3 , 2 claim 3 , 3 claim 3 , 4 claim 3 , 5 claim 3 , 6 claim 3 , 7 claim 3 , 8 claim 3 , and combinations thereof claim 3 , in the EBV-LMP2 peptide.5. The human antibody agent of claim 1 , wherein the human antibody agent comprises(a) heavy chain CDR1 of SEQ ID NO:31, CDR2 of SEQ ID NO:33 and CDR3 of SEQ ID NO:35; and wherein the human antibody agent comprises light chain CDR1 of SEQ ID NO:73, CDR2 of SEQ ID NO:75 and CDR3 of SEQ ID NO:77;(b) heavy chain CDR1 of SEQ ID NO:37, CDR2 of SEQ ID NO:39 and CDR3 of SEQ ID NO:41; and wherein the human antibody agent comprises light chain CDR1 of SEQ ID NO:79, CDR2 of SEQ ID NO:81 and CDR3 of SEQ ID NO:83;(c) heavy chain CDR1 of SEQ ID NO:43, CDR2 of SEQ ID NO:45 and CDR3 ...

ANTI-WT1/HLA BI-SPECIFIC ANTIBODY

Disclosed herein is a bi-specific form of a T cell receptor mimic (TCRm) mAb with reactivity to human immune effector cell antigen and a WT1 peptide/HLA-A epitope. This antibody selectively bound to leukemias and solid tumor cells expressing WT1 and HLA-A as well as activated resting human T cells to release interferon-(IFN-γ) and to kill the target cancer cells in vitro. Importantly, the antibody mediated autologous T cell proliferation and directed potent cytotoxicity against fresh ovarian cancer cells. Therapeutic activity in vivo of the antibody was demonstrated in NOD SCID SCID Yc* (NSG) mice with three different human cancers expressing WT1/HLA-A2 including disseminated Ph+ acute lymphocytic leukemia (ALL), disseminated acute myeloid leukemia, and peritoneal mesothelioma. In both of the leukemia xenograft models, mice that received the antibody and T cells also showed longer survival and delayed limb paralysis. Also provided are methods for stimulating a primary T cell response comprising stimulating cytotoxic T cells against a first tumor antigen and a secondary T cell response comprising stimulating effector T cells and/or memory T cells against a first tumor antigen and/or against a second tumor antigen using the bi-specific antibodies described herein. 1. A recombinant antibody comprising:(i) a first antigen-binding portion comprising:(A) a heavy chain (HC) variable region comprising HC-CDR1, HC-CDR2 and HC-CDR3, comprising amino acid sequences set forth in SEQ ID NOs: 2-4, 20-22, 38-40, 56-58, 74-76, or 92-94; and a light chain (LC) variable region comprising LC-CDR1, LC-CDR2 and LC-CDR3, comprising amino acid sequences set forth in SEQ ID NOs: 8-10, 26-28, 44-46, 62-64, 80-82, or 98-100;{'sub': H', 'L, '(B) a Vand a Vcomprising first and second amino acid sequences as set forth in SEQ ID NOs: 14 and 16, 32 and 34, 50 and 52, 68 and 70, 86 and 88, or 104 and 106; or'}(C) an scFv comprising an amino acid sequence as set forth in SEQ ID NO: 18, 36, 54, 72, ...

LIQUID CRYSTAL LENS, STEREOSCOPIC DISPLAY DEVICE AND DISPLAYING METHOD THEREOF

A liquid crystal lens includes a plurality of first stripe-shaped electrodes, a plurality of second stripe-shaped electrodes, and a plurality of third stripe-shaped electrodes. Each first stripe-shaped electrode is disposed between any two of the second stripe-shaped electrodes that are adjacent to each other, and each second stripe-shaped electrode and each first stripe-shaped electrode are arranged along a first direction alternately. The third stripe-shaped electrodes are arranged along a second direction sequentially and interlaced with the first stripe-shaped electrodes and the second stripe-shaped electrodes. Any two of the second stripe-shaped electrodes and two opposite sides of each third stripe-shaped electrode perpendicular to the second direction define a lens region. 1. A liquid crystal lens , comprising:a first substrate;a second substrate, disposed opposite to the first substrate;a liquid crystal layer, disposed between the first substrate and the second substrate;a first electrode pattern, disposed between the first substrate and the liquid crystal layer, and the first electrode pattern comprising a plurality of first stripe-shaped electrodes and a plurality of second stripe-shaped electrodes, wherein each of the first stripe-shaped electrodes is disposed between any two of the second stripe-shaped electrodes that are adjacent to each other, and each of the second stripe-shaped electrodes and each of the first stripe-shaped electrodes are arranged along a first direction alternately; anda second electrode pattern, disposed between the second substrate and the liquid crystal layer, and the second electrode pattern comprising a plurality of third stripe-shaped electrodes sequentially arranged along a second direction different from the first direction, wherein any two of the second stripe-shaped electrodes that are adjacent to each other and two opposite sides of each of the third stripe-shaped electrodes define a lens region.2. The liquid crystal lens ...

Applying a platform code level update to an operational node

Provided are a computer program product, system, and method for applying a platform code level update to update a source partition in a computing system. Computational resources in the computing system are allocated to a destination partition. A code load is applied to the destination partition to implement an updated platform code level comprising an update to the platform code level on the source partition while the source partition is operational and processing computing requests. Submission of new transactions to the source partition is blocked in response to applying the code load to the destination partition. An operational environment and system state at the source partition are migrated to the destination partition in response to blocking submission of new transactions to the source partition. Transactions are directed to the destination partition intended for the source partition in response to migrating the operational environment and system state to the destination partition.

Transmission Electron Microscopy

A transmission electron microscope is provided for imaging a sample. The microscope has a stage to hold a sample and an electron beam column to direct an electron beam onto a field of view on the sample. The electron beam column includes an electron beam source to generate an electron beam, and electron beam optics to converge the electron beam onto a field of view on the sample. The microscope also has a beam scanner to scan the electron beam across multiple fields of view on the sample. The microscope additionally has a detector to detect radiation emanating from the sample to generate an image. A controller is provided to analyze the detected radiation to generate an image of the sample. 1. A transmission electron microscope (TEM) for imaging a sample , the microscope comprising:a stage to hold a sample; an electron beam source to generate an electron beam,', 'electron beam optics to converge the electron beam as a substantially parallel electron beam onto the sample in a TEM mode, and', 'a beam scanner to scan the substantially parallel electron beam across multiple scanning areas on the sample;, 'an electron beam column to direct a substantially parallel electron beam onto the sample, the electron beam column comprisinga detector to detect radiation emanating from the sample to generate an image; anda controller to analyze the detected radiation to generate an image of the sample.2. A transmission electron microscope according to claim 1 , wherein the controller is adapted to control the beam scanner to sequentially scan the electron beam across multiple adjacent or overlapping fields of view on the sample claim 1 , without moving the stage between at least four of these scans.3. A transmission electron microscope according to claim 1 , wherein the controller is adapted to control the beam scanner to sequentially scan the electron beam across multiple adjacent or overlapping fields of view on the sample claim 1 , without moving the stage between at least nine ...

Determining Semantic Place Names from Location Reports

Systems and methods for determining semantic place names from one or more location reports received from a user device are provided. High quality visits for a candidate semantic place location from a plurality of previously obtained location reports can be aggregated and used to generate a point cloud for the semantic place location. A high quality visit can correspond to a visit by a device that is determined to be associated with a candidate semantic place location with greater likelihood relative to a plurality of other candidate semantic place locations. Data associated with one or more point clouds can be accessed and used to support determinations of semantic place name for one or more location reports. In example embodiments, the semantic place name can be stored as part of a location history and/or provided for display in a user interface presented on a display device. 1. A computer-implemented method of determining a semantic place name visited by a user device , comprising:receiving, by one or more computing devices, at least one location report associated with a user device;accessing, by the one or more computing devices, data associated with one or more point clouds, each point cloud associated with a candidate semantic place location, each point cloud generated from previously obtained location reports aggregated for a plurality of devices, each point cloud comprising a plurality of data points, each data point corresponding to a high quality visit by one of the plurality of devices to the candidate semantic place location associated with the point cloud; andidentifying, by the one or more computing devices, a semantic place name visited by the user device based at least in part on the location report and the one or more point clouds;wherein each high quality visit is identified as a visit by one of the plurality devices that is determined to be associated with the candidate semantic place location with greater likelihood relative to a plurality of ...

ADDRESS ASSIGNMENT METHOD, GATEWAY, AND SYSTEM

The present disclosure discloses an address assignment method, a gateway, and a system. The method includes: obtaining, by a control network element, first weight information of a first distributed gateway DGW, and assigning a first address segment to the first DGW according to the first weight information; and sending, by the control network element, address segment information of the first address segment to the first DGW. Proper address segment assignment is implemented, and address resource utilization is improved. 1. An address assignment method , the method comprising:obtaining, by a control network element, first weight information of a first distributed gateway (DGW), and assigning a first address segment to the first DGW according to the first weight information; andsending, by the control network element, address segment information of the first address segment to the first DGW.2. The method according to claim 1 , further comprising:receiving, by the control network element, a first message sent by a mobility management entity (MME) for indicating that a terminal device requests to obtain an Internet Protocol (IP) address; andobtaining, by the control network element, a destination IP address assigned by the first DGW to the terminal device, and returning, to the MME, a second message carrying the destination IP address.3. The method according to claim 2 , wherein obtaining claim 2 , by the control network element claim 2 , the destination IP address assigned by the first DGW to the terminal device claim 2 , and returning claim 2 , to the MME claim 2 , the second message carrying the destination IP address comprises one of the following: adding, by the control network element, a starting address of the first address segment as the destination IP address to the second message, and', 'returning the second message to the MME; and, 'when it is the first time that the first DGW assigns an IP address to the terminal device after the first DGW is powered on ...

REDUCING STORAGE FACILITY CODE LOAD SUSPEND RATE BY REDUNDANCY CHECK

Provided are techniques for code load processing. While performing code load processing of a set of modules of a same module type, it is determined that a first module in the set of modules is not in an operational state. It is determined that a second module is a redundant module for the first module. In response to determining that the second module is in an operational state and has already completed code update, the code load processing is continued. In response to determining that the second module is in an operational state and has not already completed code update, it is determined whether there is a third redundant module that is in an operational state. In response to determining that there is a third redundant module that is in an operational state, the code load processing is continued. 1. A method for code load processing , comprising: determining, with a processor of a computer, that a first module in the set of modules is not in an operational state;', 'determining that a second module is a redundant module for the first module;', 'in response to determining that the second module is in an operational state and has already completed code update, continuing the code load processing;', 'in response to determining that the second module is in an operational state and has not already completed code update, determining whether there is a third redundant module that is in an operational state; and', 'in response to determining that there is a third redundant module that is in an operational state, continuing the code load processing., 'while performing code load processing of a set of modules of a same module type,'}2. The method of claim 1 , further comprising:in response to determining that there is not any redundant module for the first module, suspending the code load processing.3. The method of claim 1 , further comprising:in response to determining that the second module is in the operational state and has not already completed code update and that ...

PROVIDING FAULT TOLERANCE IN A VIRTUALIZED COMPUTING ENVIRONMENT THROUGH A SWAPPING APPROACH

An example method to provide fault tolerance in a virtualized computing environment with a first host in a first fault domain and a second host in a second fault domain may include determining whether a primary virtualized computing instance and a secondary virtualized computing instance are both in the first fault domain. The secondary virtualized computing instance may be configured as a backup for the primary virtualized computing instance and supported by the first host. The method may further include: in response to determination that the primary virtualized computing instance and secondary virtualized computing instance are both in the first fault domain, selecting, from the second fault domain, the second host based on comparing a resource availability of each of a plurality of hosts that include the first host and the second host; and migrating the secondary virtualized computing instance from the first fault domain to the second fault domain. 1. A method to provide fault tolerance in a virtualized computing environment with a first host in a first fault domain and a second host in a second fault domain , the method comprising:determining whether a primary virtualized computing instance and a secondary virtualized computing instance are both in the first fault domain, wherein the secondary virtualized computing instance is configured as a backup for the primary virtualized computing instance and supported by the first host; selecting, from the second fault domain, the second host based on comparing a resource availability of each of a plurality of hosts that include the first host and the second host; and', 'migrating the secondary virtualized computing instance from the first host to the second host, thereby migrating the secondary virtualized computing instance from the first fault domain to the second fault domain., 'in response to determination that the primary virtualized computing instance and secondary virtualized computing instance are both in the ...

Method and System for Panorama Stitching of Trailer Images

The methods and systems for panorama stitching of trailer images provided by the present invention relates to the field of image processing, comprising: receiving, by a first on-board device, a first image data sent by a camera disposed on the left of the carriage, a second image data sent by a camera disposed on the right of the carriage, and a third image data sent by a camera disposed at the back of the carriage in real time; respectively analyzing the first image data, the second image data and the third image data utilizing an opencv algorithm, to obtain intrinsic parameters, extrinsic parameters and distortion parameters of the cameras; respectively acquiring feature points of the seventh image data, the eighth image data and the ninth image data utilizing a scale invariant algorithm to obtain a set of feature points; and stitching the first image data, the second image data and the third image data according to the set of the feature points to generate a first stitched image; utilizing an H. algorithm, the invention achieves panorama stitching of trailer images and increases the safety of a driver driving the trailer. 1. A method for panorama stitching of trailer images suitable for a first on-board device disposed within a carriage of a trailer comprises:receiving a first image data sent by a camera disposed on the left of the carriage, a second image data sent by a camera disposed on the right of the carriage, and a third image data sent by a camera disposed at the back of the carriage in real time;respectively analyzing the first image data, the second image data and the third image data utilizing an openCV algorithm, to obtain intrinsic parameters, extrinsic parameters and distortion parameters of the cameras;respectively correcting the first image data, the second image data and the third image data according to the distortion parameters and a linear interpolation algorithm, to generate a fourth image data, a fifth image data and a sixth image data; ...

HOLISTIC DOCUMENT SEARCH

A set of documents is parsed. Members of the set of documents include a set of text elements and a set of visual elements. A text content stream based on the set of text elements and a visual content stream based on the set of visual elements are produced. For respective documents, a set of respective visual element summarizations is built from the visual content stream. Each visual summarization includes a text description of a respective visual element in the respective document. A holistic index is created by indexing the text content from the text content stream and the text descriptions of the visual elements in a single search index. The indexing uses a set of semantic relationships between the text content from the text content stream and the textual descriptions of the visual elements. A user interface allows a user to selectively search text content and visual content. 1. A method for searching a set of documents comprising:parsing a set of documents, respective members of the set of documents including a set of text elements and a set of visual elements, to produce a text content stream based on the set of text elements and a visual content stream based on the set of visual elements;for respective documents in the set of documents, building a set of respective visual element summarizations from the visual content stream, each visual summarization including a description of a respective visual element in the respective document in a textual form;creating a holistic index by indexing the text content from the text content stream and the textual descriptions of the visual elements in a single search index, wherein the indexing is performed according to a set of semantic relationships between the text content from the text content stream and the textual descriptions of the visual elements; anddisplaying a user interface allowing a user to selectively retrieve text content and visual content from the set of documents.2. The method as recited in claim 1 , ...

HOLISTIC DOCUMENT SEARCH

A set of documents is parsed. Members of the set of documents include a set of text elements and a set of visual elements. A text content stream based on the set of text elements and a visual content stream based on the set of visual elements are produced. For respective documents, a set of respective visual element summarizations is built from the visual content stream. Each visual summarization includes a textual description of a respective visual element in the respective document. A holistic index is created by indexing the text content from the text content stream and the text descriptions of the visual elements for each document in a single search index. The indexing uses a set of semantic relationships between the text content from the text content stream and the textual descriptions of the visual elements. A user interface allows a user to selectively search text content and visual content. 1. An improved method for indexing a set of documents comprising:parsing a set of documents, respective members of the set of documents including a set of text elements and a set of visual elements, to produce a text content stream based on the set of text elements and a visual content stream based on the set of visual elements;for respective documents in the set of documents, building a set of respective visual element summarizations from the visual content stream, each visual summarization including a textual description of a respective visual element in the respective document;creating a holistic index by indexing the text content from the text content stream and the textual descriptions the visual elements in a single search index, wherein the indexing is performed for each document according to a set of semantic relationships between the text content from the text content stream from a particular document and the textual descriptions of the visual elements from the particular document; anddisplaying a user interface allowing a user to selectively retrieve text ...

PROVIDING SEMANTICALLY RELEVANT ANSWERS TO QUESTIONS

A device implementing a system for determining whether a semantically relevant answer can be provided with respect to a new question includes a processor configured to identify a question and a semantically relevant answer from source data, and to identify a semantically irrelevant answer to the question from a corpus of data corresponding to the source data based at least in part on the question and the answer. The processor is configured to assign a positive label to the semantically relevant answer, and a negative label to the semantically irrelevant answer. The processor is configured to generate a machine learning model based on the question, the positive label assigned to the semantically relevant answer, and the negative label assigned to the semantically irrelevant answer, and to provide the machine learning model to facilitate a determination of whether a semantically relevant answer can be provided with respect to a subsequent question. 1. A device , comprising:at least one processor; and identify a question and an answer to the question based on source data, the answer being determined to be semantically relevant with respect to the question;', 'perform a search on a corpus of data corresponding to the source data, based at least in part on the question and the answer to obtain another answer to the question, the other answer being determined to be semantically irrelevant with respect to the question;', 'assign a positive label to the answer that is semantically relevant with respect to the question, and a negative label to the other answer that is semantically irrelevant with respect to the question;', 'generate a machine learning model based at least in part on the question, the positive label assigned to the answer that is semantically relevant, and the negative label assigned to the other answer that is semantically irrelevant; and', 'provide the machine learning model to facilitate a determination of whether a likely semantically relevant answer can ...

METHOD OF METAL POLISHING AND OXIDATION FILM PROCESS AND SYSTEM THEREOF

The present invention is a method of metal polishing and oxidation film process applied on a metal workpiece. The process comprises (a) providing the metallic workpiece in an electrolysis polishing liquid; (b) a temperature control device controlling a liquid temperature of the electrolysis polishing liquid; (c) a voltage supply device to exercising an operating voltage between the metallic workpiece and the electrolysis polishing liquid; (d) polishing the surface of the metallic workpiece and forming an oxidation layer by regulating the temperature control device and the voltage supply device; and (e) determining a film thickness of the oxidation layer formed on the metallic workpiece according to an operation time, wherein the film thickness is related to a roughness and a color displayed on the metallic workpiece. The metallic workpiece may be dyed together during the polishing process without adding any dyes. The present invention further provides a system of alloy oxidation film process. 1. A method of metal polishing and oxidation film process applied on a metallic workpiece comprising:(a) providing the metallic workpiece in an electrolysis polishing liquid, wherein the electrolysis polishing liquid comprises an inorganic acid and a bio-bacteria;(b) a temperature control device controlling a liquid temperature of the electrolysis polishing liquid;(c) a voltage supply device exercising an operating voltage on the electrolysis polishing liquid;(d) forming an oxidation layer on the metallic workpiece by regulating the temperature control device and the voltage supply device, wherein the electrolysis polishing liquid is operated under a condition that the liquid temperature is less or equal to 5° C. and the operating voltage is more or equal to 15 V; and(e) determining a film thickness of the oxidation layer formed on the metallic workpiece according to an operation time, wherein the film thickness is related to a roughness and a color displayed by the metallic ...

Biochemical analyzer

Provided is a biochemical analyzer, which includes a housing, a sample feeding mechanism, a rotating mechanism, a pipetting mechanism, analyzing mechanisms, a sample discharging mechanism and a sample discharging box, wherein a sample feeding port and a sample discharging port are formed in the housing; the sample feeding mechanism is arranged in the housing and capable of introducing detection cards containing samples and reagents into the housing from the sample feeding port; the rotating mechanism is capable of clamping a plurality of detection cards and driving the detection cards to rotate; the sample feeding mechanism is capable of clamping the detection cards on the rotating mechanism; the pipetting mechanism is capable of mixing the samples with the reagents on the detection cards; the analyzing mechanisms are capable of analyzing the samples through detection rays; the sample discharging mechanism is used for removing the detection cards from the rotating mechanism.

Ror2 antibody

The invention relates to antibodies, and in particular, to antibodies exhibiting specificity for Receptor tyrosine kinase-like Orphan Receptors (ROR), and to uses thereof, for example in the treatment of cancer. The invention extends to polynucleotide and polypeptide sequences encoding the antibodies, and therapeutic uses thereof, and to diagnostic kits comprising these molecules. The invention also extends to antibody-drug conjugates and to uses thereof in therapy.

Modified glycoproteins and uses thereof

The present disclosure provides compositions and methods comprising cells producing glycoproteins with variant glycosylation patterns. The methods and compositions may be used in producing antibodies and proteins of therapeutic value.

Modified host cells and uses thereof

The present disclosure provides compositions and methods comprising cells producing glycoproteins with variant glycosylation patterns. The methods and compositions may be used in producing antibodies and proteins of therapeutic value.

Methods for generating host cells

The present disclosure provides compositions and methods comprising cells producing glycoproteins with variant glycosylation patterns. The methods and compositions may be used in producing antibodies and proteins of therapeutic value.

Antibody/t-cell receptor chimeric constructs and uses thereof

The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.

T cell receptor-like antibody agents specific for EBV latent membrane protein 2A peptide presented by human HLA

Described herein are antibodies, fragments thereof and multi-specific binding agents that bind an Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2) peptide presented by HLA class I molecules, in particular, HLA-A02. Also provided herein are methods of using the same or compositions thereof for the detection, prevention and/or therapeutic treatment of diseases characterized by expression of an EBV-LMP2 peptide presented by HLA-A02, in particular, Burkit's lymphoma, Hodgkin's lymphoma and nasopharyngeal carcinoma.

T cell receptor-like antibody agents specific for EBV latent membrane protein 2A peptide presented by human HLA

Described herein are antibodies, fragments thereof and multi-specific binding agents that bind an Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2) peptide presented by HLA class I molecules, in particular, HLA-A02. Also provided herein are methods of using the same or compositions thereof for the detection, prevention and/or therapeutic treatment of diseases characterized by expression of an EBV-LMP2 peptide presented by HLA-A02, in particular, Burkit's lymphoma, Hodgkin's lymphoma and nasopharyngeal carcinoma.

T cell receptor-like antibody agents specific for ebv latent membrane protein 2a peptide presented by human hla

Described herein are antibodies, fragments thereof and multi-specific binding agents that bind an Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2) peptide presented by HLA class I molecules, in particular, HLA-A02. Also provided herein are methods of using the same or compositions thereof for the detection, prevention and/or therapeutic treatment of diseases characterized by expression of an EBV-LMP2 peptide presented by HLA-A02, in particular, Burkit's lymphoma, Hodgkin's lymphoma and nasopharyngeal carcinoma.

Anti-kir3dl1 antibodies

The disclosure provides antibody agents that bind to inhibitory human killer immunoglobulin-like receptors (KIRs). Particular antibody agents of the disclosure include antibody agents that bind to KIR3DL1 (also known as CD158e). Also provided are related nucleic acids, vectors, compositions and methods of using KIR-binding antibody agents of the present technology.

T cell receptor-like antibodies specific for a prame peptide

T cell receptor-like antibodies specific for a PRAME peptide

The presently disclosed subject matter provides antigen-binding proteins that specifically bind to Preferentially expressed antigen of melanoma (PRAME), including humanized, chimeric and fully human antibodies against PRAME, antibody fragments (e.g., scFv, Fab and F(ab)2), chimeric antigen receptors (CARs), fusion proteins, and conjugates thereof. The antigen-binding proteins and antibodies bind to a PRAME peptide/HLA class I molecule complex. Such antibodies, fragments, fusion proteins and conjugates thereof are useful for the treatment of PRAME associated diseases, including for example, breast cancer, ovarian cancer, melanoma, lung cancer, gastrointestinal cancer, brain tumor, head and neck cancer, renal cancer, myeloma, neuroblastoma, mantle cell lymphoma, chronic myelocytic leukemia, multiple myeloma, acute lymphoblastic leukemia (ALL), acute myeloid/myelogenous leukemia (AML), Non-Hodgkin lymphoma (NHL), and Chronic lymphocytic leukemia (CLL). The antibodies or antigen binding proteins may comprise one or more framework region amino acid substitutions designed to improve protein stability, antibody binding and/or expression levels.

Memory device with organic thin-film transistor (otft) structure

Organic light-emitting diode package structure and method of manufacturing concavity on substrate

本發明提供一種有機發光二極體封裝結構，包括一第一基板、一第二基板、至少一有機發光二極體元件、以及一框膠。第一基板與第二基板之一表面相對設置，其中第二基板之表面具有複數個凹穴，且第二基板於各凹穴內之表面係為一透鏡面。有機發光二極體元件設置於第一基板上，且具有一發光面，面對第二基板。框膠設置於第一基板與第二基板之間，並接合第一基板與第二基板，且框膠圍繞有機發光二極體元件。

T cell receptor-like antibodies specific for a wt1 peptide presented by hla-a2

Disclosed is an isolated antibody, or antigen-binding fragment thereof, comprising: (i) a heavy chain (HC) variable region comprising HC-CDR1, HC- CDR2 and HC-CDR3 respectively, comprising amino acid sequences GGTFSSYAIS, GIIPIFGTANYAQKFQG, and RIPPYYGMDV; and a light chain (LC) variable region comprising LC-CDR1, LC-CDR2 and LCCDR3 respectively, comprising amino acid sequences SGSSSNIGSNYVY, RSNQRPS, and AAWDDSLNGVV; (ii) a heavy chain (HC) variable region comprising HC-CDR1, HC- CDR2 and HC-CDR3 respectively, comprising amino acid sequences GDSVSSNSAAWN, RTYYGSKWYNDYAVSVKS, and GRLGDAFDI; and a light chain (LC) variable region comprising LC-CDR1, LC-CDR2 and LC- CDR3 respectively, comprising amino acid sequences RASQSISSYLN, AASSLQS, and QQSYSTPLT; (iii) a heavy chain (HC) variable region comprising HC-CDR1, HC- CDR2 and HC-CDR3 respectively, comprising amino acid sequences GYSFTNFWIS, RVDPGYSYSTYSPSFQG, and VQYSGYYDWFDP; and a light chain (LC) variable region comprising LC-CDR1, LC-CDR2 and LC- CDR3 respectively, comprising amino acid sequences selected from SGSSSNIGSNTVN, SNNQRPS, and AAWDDSLNGWV; (iv) a heavy chain (HC) variable region comprising HC-CDR1, HC- CDR2 and HC-CDR3 respectively, comprising amino acid sequences GYNFSNKWIG, IIYPGYSDITYSPSFQG, and HTALAGFDY; and a light chain (LC) variable region comprising LC-CDR1, LC-CDR2 and LC- CDR3 respectively, comprising amino acid sequences RASQNINKWLA, KASSLES, and QQYNSYAT; (v) a heavy chain (HC) variable region comprising HC-CDR1, HC- CDR2 and HC-CDR3 respectively, comprising amino acid sequences GFTFDDYGMS, GINWNGGSTGYADSVRG, and ERGYGYHDPHDY; and a light chain (LC) variable region comprising LC-CDR1, LC-CDR2 and LC- CDR3 respectively, comprising amino acid sequences GRNNIGSKSVH, DDSDRPS, and QVWDSSSDHVV; or (vi) a heavy chain (HC) variable region comprising HC-CDR1, HC- CDR2 and HC-CDR3 respectively, comprising amino acid sequences GFSVSGTYMG, LLYSGGGTYHPASLQG, and GGAGGGHFDS; and a light chain (LC) ...

Selective control method for driving state of intermittent video recording and reproducing device

(57)【要約】 【課題】 本発明は、間欠録画再生器 (Time-lapse VC R) の駆動状態の選択的制御方法を提供する。 【解決手段】 使用者により入力された間欠撮影設定モ ードを確認し（Ｓ11）、これに基づいて録画部の録画待 機時間を計算する（Ｓ11）。計算された録画待機時間 が、予め設定されたローディング状態転換の基準時間よ り長時間であるか、短時間であるかを確認して（Ｓ1 5）、基準時間以上の場合には、録画待機時間中にアン ローディング状態へ転換させ、実際に録画を行なう場合 だけローディング状態へ再び復帰させるローディング／ アンローディング状態の反復転換モードと設定し（Ｓ1 7）、基準時間以内の場合には、録画中はもちろん、録 画待機時間中でも常時ローディング状態を維持するモー ドと設定するか（Ｓ19）、あるいは前記アンローディン グ状態へ転換する代わりにヘッドドラムの回転駆動を停 止させる。

Approximate named-entity extraction

According to one embodiment, approximate named-entity extraction from a dictionary that includes entries is provided, where each of the entries includes one or more words. Words are read from the entries of the dictionary, and network resources are searched to determine a frequency of occurrence of the words on the network resources. In view of the frequency of occurrence of the words located on the network resources, domain relevancy of the words in the entries of the dictionary is determined. A domain repository is created using top-ranked words as determined by the domain relevancy of the words. In view of the domain repository, signatures for both the entries of the dictionary and strings of an input document are computed. The strings of the input document are filtered by comparing the signatures of the strings against the signatures of the entries to identify approximate-match entity names.

T cell receptor-like antibodies specific for a wt1 peptide presented by hla-a2

Semiconductor device with integrated metallic heat sink and method for its production

Halbleitereinrichtung mit integriertem metallischen Kühlkörper, mit: einer dünnen Metallschicht (114), welche eine erste Fläche und eine zweite Fläche aufweist, welche auf einander gegenüberliegenden Seiten angeordnet sind, wobei wenigstens eine Halbleitereinrichtung (108a) in die erste Fläche der dünnen Metallschicht (114) eingebettet ist, und die Halbleitereinrichtung zwei Elektroden (110, 112) von unterschiedlichem Leitertypus aufweist; einem metallischen Kühlkörper (122), welcher auf der zweiten Fläche der dünnen Metallschicht (114) aufgetragen ist; und zwei Anschlussflächen (128, 134), welche auf der ersten Fläche der dünnen Metallschicht (114) um die Halbleitereinrichtung (108a) aufgetragen sind und jeweils mit den beiden Elektroden (110, 112) verbunden sind, wobei die Elektroden (110, 112) jeweils mit einer zugehörigen der Anschlussflächen (128, 134) verbunden sind, wozu wenigstens zwei Drähte (136, 138) vorgesehen sind, und die Anschlussflächen (128, 134) elektrisch an einen äußeren Schaltkreis anschließbar sind. Semiconductor device with integrated metallic heat sink, with: a thin metal layer (114) having a first surface and a second surface disposed on opposite sides, wherein at least one semiconductor device (108a) is embedded in the first surface of the thin metal layer (114), and the semiconductor device comprises two electrodes (110, 112) of different conductor type; a metallic heat sink (122) deposited on the second surface of the thin metal layer (114); and two pads (128, 134) deposited on the first surface of the thin metal layer (114) around the semiconductor device (108a) and connected respectively to the two electrodes (110, 112), the electrodes (110, 112) respectively are connected to an associated one of the pads (128, 134), for which purpose at least two wires (136, 138) are provided, and the pads (128, 134) are electrically connectable to an external circuit.

T cell receptor-like antibodies specific for a WT1 peptide presented by HLA-A2

The present invention provides antigen binding proteins that specifically bind to Wilms' tumor protein (WT1), including humanized, chimeric and fully human antibodies against WT1, antibody fragments, chimeric antigen receptors (CARs), fusion proteins, and conjugates thereof. The antigen binding proteins and antibodies bind to HLA-A0201-restricted WT1 peptide. Such antibodies, fragments, fusion proteins and conjugates thereof are useful for the treatment of WT1 associated cancers, including for example, breast cancer, ovarian cancer, prostate cancer, chronic myelocytic leukemia, multiple myeloma, acute lymphoblastic leukemia (ALL), acute myeloid/myelogenous leukemia (AML) and myelodysplastic syndrome (MDS). In more particular embodiments, the anti-WT1/A antibodies may comprise one or more framework region amino acid substitutions designed to improve protein stability, antibody binding and/or expression levels.