07-08-2014 дата публикации
Номер: US20140220006A1
The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein. 1. A method for evaluating the efficacy of a treatment regimen in a patient diagnosed with lung cancer , said method comprising(a) obtaining a test sample from a patient undergoing said treatment regimen for lung cancer;(b) measuring a level of a biomarker in said test sample, wherein said biomarker comprises MDC, NME-2, KGF, PIGF, Flt-3L, HGF, MCP1, SAT-1, MIP-1-b, GCLM, OPG, TNF RII, VEGF-D, ITAC, MMP-10, GPI, PPP2R4, AKR1B1, Amy1A, MIP-1b, P-Cadherin, EPO, and combinations thereof;(c) comparing said level to a normal control level of said biomarker; and(d) evaluating from said comparing step (c) whether said patient is responsive to said treatment regimen.2. A method for evaluating the efficacy of a treatment regimen in a patient diagnosed with lung cancer , said method comprising(a) ordering a test comprising a measurement of a level of a biomarker in a test sample obtained from a patient undergoing said treatment regimen for lung cancer, wherein said biomarker comprises MDC, NME-2, KGF, PIGF, Flt-3L, HGF, MCP1, SAT-1, MIP-1-b, GCLM, OPG, TNF RII, VEGF-D, ITAC, MMP-10, GPI, PPP2R4, AKR1B1, Amy1A, MIP-1b, P-Cadherin, EPO, and combinations thereof;(b) comparing said level to a normal control level of said biomarker; and(c) evaluating from said comparing step (b) whether said patient is responsive to said treatment regimen.3. A method of administering a treatment regimen to a patient in need thereof for treating lung cancer , comprising:(a) obtaining a test sample from a patient undergoing said treatment regimen for lung cancer;(b) measuring a level of a biomarker in said test sample, wherein said biomarker comprises ...
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