Pharmaceutical composition for treatment of diabetes and dyslipidemia

A bioactive fraction obtained from Xylocarpus that is useful for the treatment of diabetes and dyslipidemia. This fraction can be provided in a pharmaceutical composition that is useful as antidiabetic and antidyslipidemic agent, or can be used in a method of treating diabetes and dyslipidemia in a subject. Also, a process for the preparation of bioactive fraction from Xylocarpus . Isomeric xyloccensins and the preparation of such compounds. Also, pharmaceutical compositions comprising a therapeutically effective amount of such isomeric xyloccensins optionally along with one or more pharmaceutically acceptable carriers, additives, lubricant and diluents and the use of such pharmaceutical compositions in a method for treating dyslipidemia.

Furazanobenzimidazoles

The invention relates to compounds of formula (I) wherein R represents aryl or heteroaryl, X is oxygen, a carbonyl group, an oxime derivative of a carbonyl group or an alpha,beta-unsaturated carbonyl group, and the substituents R¹ to R⁶ have the meanings given in the specification, for use as medicaments, to novel compounds of formula (I), to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to the use of a compounds of formula (I) for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same ...

Apparatus for delivering gas and illumination source for generating high harmonic radiation

Disclosed is gas delivery system which is suitable for a high harmonic generation (HHG) radiation source which may be used to generate measurement radiation for an inspection apparatus. In such a radiation source, a gas delivery element delivers gas in a first direction. The gas delivery element has an optical input and an optical input, defining an optical path running in a second direction. The first direction is arranged relative to the second direction at an angle that is not perpendicular or parallel. Also disclosed is a gas delivery element having a gas jet shaping device, or a pair of gas delivery elements, one of which delivers a second gas, such that the gas jet shaping device or second gas is operable to modify a flow profile of the gas such that the number density of the gas falls sharply.

Substituted benzimidazoles and their use for inducing apoptosis

The invention relates to compounds of formula (I) wherein R represents aryl or heteroaryl, X is a bond, a carbonyl group, a derivative of a carbonyl group, an ethylene group or an ethylenecarbonyl group, R¹ is optionally substituted amino or hydroxy, and the substituents R² to R⁶ have the meanings given in the specification, to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to intermediates, to the use of a compounds of formula (I) as a medicament and for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same.

Method for the treatment of malaria by the use of primaquine derivative N1-(3-ethylidinotetrahydrofuran-2-one)-N4- (6-methoxy-8-quinolinyl)-1,4-pentanediamine as gametocytocidal agent

The present invention a novel use of primaquine derivative N¹-(3-ethylidinotetrahydrofuran-2-one)-N⁴-(6-methoxy-8-quinolinyl)-1,4-pentanediamine in the treatment and controlling the spread of malaria. In particular, the present invention discloses a method of treatment of malaria by the use of primaquine derivative N¹-(3-ethylidinotetrahydrofuran-2-one)-N⁴-(6-methoxy-8-quinolinyl)-1,4-pentanediamine as a gametocytocidal agent.

Substituted benzimidazoles and their use for inducing apoptosis

The invention relates to compounds of formula (I) wherein R represents aryl or heteroaryl, X is a bond, a carbonyl group, a derivative of a carbonyl group, an ethylene group or an ethylenecarbonyl group, R1 is optionally substituted amino or hydroxy, and the substituents R2 to R6 have the meanings given in the specification, to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to intermediates, to the use of a compounds of formula (I) as a medicament and for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same.

Pharmaceutical composition for treatment of diabetes and dyslipidemia

A bioactive fraction obtained from Xylocarpus that is useful for the treatment of diabetes and dyslipidemia. This fraction can be provided in a pharmaceutical composition that is useful as antidiabetic and antidyslipidemic agent, or can be used in a method of treating diabetes and dyslipidemia in a subject. Also, a process for the preparation of bioactive fraction from Xylocarpus. Novel isomeric xyloccensins and the preparation of such compounds. Also, pharmaceutical compositions comprising a therapeutically effective amount of such novel isomeric xyloccensins optionally along with one or more pharmaceutically acceptable carriers, additives, lubricant and diluents and the use of such pharmaceutical compositions in a method for treating dyslipidemia.

Novel uses of Gugulipid: as cognition enhancer, anti-hyperglycemic and for dermal conditions

The present invention provides new uses of Gugulipid, an ethyl acetate extract of the resin of the plant Comiphora wighitii, for controlling or preventing cognitive dysfunction, hyperglycemia and some infective conditions of the skin and a method of preparing Gugulipid by agitating the resin in shake flask assembly or sonicating assembly and preparing a solid or a creamy dosage forms.

Substituted Benzimidazoles and their Use for Inducing Apoptosis

The invention relates to compounds of formula (I) wherein R represents aryl or heteroaryl, X is a bond, a carbonyl group, a derivative of a carbonyl group, an ethylene group or an ethylenecarbonyl group, R1 is optionally substituted amino or hydroxy, and the substituents R2 to R6 have the meanings given in the specification, to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to intermediates, to the use of a compounds of formula (I) as a medicament and for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same.

LOCALIZATION QUALITY ASSURANCE OF LOCALIZED SOFTWARE

Described herein are representative embodiments for localization quality assurance (LQA) of localized software. In one exemplary implementation, a localization quality assurance plan for performing LQA of a localized software based on a base-language software is developed, and using the localization quality assurance plan, the LQA is performed for the localized software at least by performing a first test phase of one or more test phases. In the first test phase, one or more screen maps are created for a localized-software build using first location resources at a first location, and the one or more screen maps are evaluated using second location resources at a second location. Also, one or more resource bundles for the first localized-software build are generated based on the evaluating of the one or more screen maps. Additionally, a second localized-software build is generated using the first location resources based on the one or more resource bundles. 1. A method implemented at least in part by a computer , the method comprising:developing a localization quality assurance plan for performing localization quality assurance of at least a localized software based at least in part on a base language software, the base language software comprising a first user interface in a first language, and the localized software comprising a second user interface in a second language; using first location resources at a first location, creating one or more screen maps for a first localized-software build;', 'using second location resources at a second location, evaluating the one or more screen maps;', 'based at least in part on the evaluating, generating one or more resource bundles for the first localized-software build; and', 'based at least in part on the one or more resource bundles, generating a second localized-software build using the first location resources., 'using the localization quality assurance plan, performing the localization quality assurance of the localized ...

Aroylfuranes and aroylthiophenes

The invention relates to novel substituted 2-(phenyl-, pyridyl- or pyrimidyl-carbonyl)-furanes and -thiophenes and related phenoxy/phenylthio-acetophenones and corresponding heterocyclic compounds, processes for the preparation thereof, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of neoplastic diseases and autoimmune diseases, and a method for the treatment of such a diseases.

Novel uses of gugulipid: as cognition enhancer, anti-hyperglycemic and for dermal conditions

The present invention provides new uses of Gugulipid, an ethyl acetate extract of the resin of the plant Comiphora wighitii, for controlling or preventing cognitive dysfunction, hyperglycemia and some infective conditions of the skin and a method of preparing Gugulipid by agitating the resin in shake flask assembly or sonicating assembly and preparing a solid or a creamy dosage forms.

Combination kit used in the treatment of malaria

A combination kit for the treatment of malaria caused by Plasmodium vivax (P. vivax) having individual doses of an anti-malarial agent, 3-[1-[[4-[(6-methoxy-8-quinolinyl)amino]pentyl]amino]ethylidene]-dihydro-2(3H)-furanone (I) in the form of capsules; individual doses of the anti-malarial agent, chloroquine in the form of tablets; and instruction material for the administration of the two anti-malarial drugs. The combination kit is particularly suited for a 6 days treatment regimen where the treatment is rendered by five tablets containing 500 mg of chloroquine phosphate (equivalent to 300 mg base), three to be taken on day one and one each on days two and three; and five capsules containing 25 mg of 3-[1-[[4-[(6-methoxy-8-quinolinyl)amino]pentyl]amino]ethylidene]-dihydro-2(3H)-furanone (I), one each to be taken on days two to six.

Furazanobenzimidazoles

The invention relates to compounds of formula (I) wherein R represents aryl or heteroaryl, X is oxygen, a carbonyl group, an oxime derivative of a carbonyl group or an α,β-unsaturated carbonyl group, and the substituents R1 to R6 have the meanings given in the specification, for use as medicaments, to novel compounds of formula (I), to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to the use of a compounds of formula (I) for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same ...

Apparatus for delivering gas and illumination source for generating high harmonic radiation

Disclosed is a high harmonic generation (HHG) radiation source which may be used to generate measurement radiation for an inspection apparatus. In such a radiation source, a pump radiation source is operable to emit pump radiation at a high harmonic generation gas medium thereby exciting the high harmonic generation gas medium within a pump radiation interaction region so as to generate the high harmonic radiation and an ionization radiation source is operable to emit ionization radiation at the high harmonic generation gas medium to ionize a gas at an ionization region between the pump radiation interaction region and an optical output of the illumination source.

Inclusion complees of a high potent opioid peptide, pharmaceutical compositions and method of treatment

The invention provides novel inclusion complexes of highly potent opioid peptide of L-Tyrosyl-D-alanyl-glycyl-N-methylphenylalanyl-glycyl-isopropylamide with cyclodextrin, pharmaceutical preparations containing these inclusion complexes of L-Tyrosyl-D-alanyl-glycyl-N-methylphenylalanyl-glycyl-isopropylamide with cyclodextrin derivatives, the complexes being better soluble in water and having improved biopharmaceutical properties such as lesser toxicity, better analgesic action and non-addiction properties.

Furazanobenzimidazoles

The invention relates to compounds of formula (I) wherein R represents aryl or heteroaryl, X is oxygen, a carbonyl group, an oxime derivative of a carbonyl group or an α,β-unsaturated carbonyl group, and the substituents R1 to R6 have the meanings given in the specification, for use as medicaments, to novel compounds of formula (I), to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to the use of a compounds of formula (I) for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same.

Substituted benzimidazoles and their use for inducing apoptosis

The invention relates to compounds of formula (I) wherein R represents aryl or heteroaryl, X is a bond, a carbonyl group, a derivative of a carbonyl group, an ethylene group or an ethylenecarbonyl group, R1 is optionally substituted amino or hydroxy, and the substituents R2 to R6 have the meanings given in the specification, to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to intermediates, to the use of a compounds of formula (I) as a medicament and for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same.

Substituted benzimidazoles and their use for inducing apoptosis

The invention relates to compounds of formula (I) wherein R represents aryl or heteroaryl, X is a bond, a carbonyl group, a derivative of a carbonyl group, an ethylene group or an ethylenecarbonyl group, R1 is optionally substituted amino or hydroxy, and the substituents R2 to R6 have the meanings given in the specification, to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to intermediates, to the use of a compounds of formula (I) as a medicament and for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same.

Pressure control valve, a fluid handling structure for lithographic apparatus and a lithographic apparatus

A pressure control valve has: a passageway having a flow opening; an member displaceable relative to the opening for obstructing the opening by differing amounts; a piezo actuator; and a linkage mechanism adapted to amplify a dimensional change in the piezo actuator and to use the amplified dimensional change to displace the member relative to the opening, wherein the linkage mechanism comprises a frame attached to a wall and fixed at a first end in relation to the passageway, a portion of the frame moveable in a first direction while being substantially restrained in a second direction orthogonal to the first direction, the piezo actuator extending between the wall and the movable portion such that an expansion of the piezo actuator results in movement of the movable portion in the first direction by an amount greater than the expansion of the piezo actuator, the moveable portion connected to the member.

Method of treating a cognitive memory dysfunction using Gugulipid

The present invention provides new uses of Gugulipid, an ethyl acetate extract of the resin of the plant Comiphora wighitii , for controlling or preventing cognitive dysfunction, hyperglycemia and some infective conditions of the skin and a method of preparing Gugulipid by agitating the resin in shake flask assembly or sonicating assembly and preparing a solid or a creamy dosage forms.

Aroylfuranes and aroylthiophenes

The invention relates to novel substituted 2-(phenyl-, pyridyl- or pyrimidyl-carbonyl)-furanes and -thiophenes and related phenoxy/phenylthio-acetophenones and corresponding heterocyclic compounds, processes for the preparation thereof, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of neoplastic diseases and autoimmune diseases, and a method for the treatment of such a diseases.

A pressure control valve, a fluid handling structure for lithographic apparatus and a lithographic apparatus

A pressure control valve has: a passageway having a flow opening; an member displaceable relative to the opening for obstructing the opening by differing amounts; a piezo actuator; and a linkage mechanism adapted to amplify a dimensional change in the piezo actuator and to use the amplified dimensional change to displace the member relative to the opening, wherein the linkage mechanism comprises a frame attached to a wall and fixed at a first end in relation to the passageway, a portion of the frame moveable in a first direction while being substantially restrained in a second direction orthogonal to the first direction, the piezo actuator extending between the wall and the movable portion such that an expansion of the piezo actuator results in movement of the movable portion in the first direction by an amount greater than the expansion of the piezo actuator, the moveable portion connected to the member.

PRESSURE CONTROL VALVE, A FLUID HANDLING STRUCTURE FOR LITHOGRAPHIC APPARATUS AND A LITHOGRAPHIC APPARATUS

A pressure control valve has: a passageway having a flow opening; an member displaceable relative to the opening for obstructing the opening by differing amounts; a piezo actuator; and a linkage mechanism adapted to amplify a dimensional change in the piezo actuator and to use the amplified dimensional change to displace the member relative to the opening, wherein the linkage mechanism comprises a frame attached to a wall and fixed at a first end in relation to the passageway, a portion of the frame moveable in a first direction while being substantially restrained in a second direction orthogonal to the first direction, the piezo actuator extending between the wall and the movable portion such that an expansion of the piezo actuator results in movement of the movable portion in the first direction by an amount greater than the expansion of the piezo actuator, the moveable portion connected to the member. 114-. (canceled)15. A control valve comprising:a passageway having a portion defining an opening for the flow of liquid and/or gas therethrough;an obstructing member displaceable relative to the opening for obstructing the opening by differing amounts thereby to regulate a volumetric flow rate of liquid and/or gas through the opening;a piezo actuator; anda linkage mechanism configured to amplify a magnitude of a dimensional change in the piezo actuator and to use the amplified dimensional change to displace the obstructing member relative to the opening,wherein the linkage mechanism comprises an elongate deformable member having a first end and a second end, the first end and the second end of the elongate deformable member connected to opposite ends of the piezo actuator, andwherein, when the piezo actuator expands due to a potential difference applied thereto, a magnitude of movement of a central portion of the elongate deformable member in a direction away from the piezo actuator is greater than the amount of expansion of the piezo actuator itself.16. The ...

Apparatus For Delivering Gas and Illumination Source for Generating High Harmonic Radiation

Disclosed is a high harmonic generation (HHG) radiation source which may be used to generate measurement radiation for an inspection apparatus. In such a radiation source, a pump radiation source is operable to emit pump radiation at a high harmonic generation gas medium thereby exciting the high harmonic generation gas medium within a pump radiation interaction region so as to generate the high harmonic radiation and an ionization radiation source is operable to emit ionization radiation at the high harmonic generation gas medium to ionize a gas at an ionization region between the pump radiation interaction region and an optical output of the illumination source. 1. An illumination source for generating high harmonic radiation , comprising:a pump radiation source operable to emit pump radiation at a high harmonic generation gas medium thereby exciting the high harmonic generation gas medium within a pump radiation interaction region so as to generate the high harmonic radiation; andan ionization radiation source operable to emit ionization radiation at the high harmonic generation gas medium to ionize a gas at an ionization region between the pump radiation interaction region and an optical output of the illumination source.2. The illumination source of claim 1 , wherein the ionization region is adjacent to the pump radiation interaction region.3. The illumination source of claim 1 , wherein the illumination source is arranged such that the ionization radiation ionizes the gas at the ionization region substantially simultaneously with the pump radiation exciting the high harmonic generation gas medium.4. The illumination source of claim 1 , wherein a propagation direction of the ionization radiation is opposite to a propagation direction of the pump radiation.5. The illumination source of claim 1 , wherein a propagation direction of the ionization radiation is orthogonal to a propagation direction of the pump radiation.6. The illumination source of claim 1 , ...

Modular interface for a robotic system

The disclosure is directed to a medical robotic system and method for releasably securing a medical instrument over a modular support assembly that is further removably coupled to the manipulating arm via an intermediate fastening component. The medical instrument is configured for delivery through a small percutaneous penetration in a patient as it slides over the modular support assembly, independent of the manipulating arm. The robotic system further includes a simplified draping mechanism including covering the manipulating arm up to the fastening component thereby obviating the need for extensive sterile drape that extends all over the arm up to the support interface and the cannula holding assembly in existing art. Advantageously, the present invention allows for a quick and simple installation while allowing for free rotary motion of the support assembly.

ANASTOMOSIS DEVICE

An Anastomosis Device is intended to create an end-to-side anastomosis between a graft vessel and a target vessel. The anastomosis is created by the delivery of staples that connect the graft vessel to the target vessel and the creation of an incision to open a flow path between the graft vessel and the target vessel. 1{'b': '345', 'an interface ();'}{'b': '343', 'a flexible shaft (); and'}{'b': 301', '343', '345', '301', '301', '309', '301', '307', '301', '309', '337', '335', '307', '315, 'an end effector (), the flexible shaft () connecting the interface () and the end effector (), the end effector () including an anvil () extending from the end effector () and a cartridge () pivotably attached to the end effector (), the anvil () including a knife () and knife block (), the cartridge () including a body () for receiving at least one tissue fastener.'}. An anastomosis device comprising: The present application claims priority to and the benefit from U.S. Provisional Patent Application No. 62/987258 entitled “AN ANASTOMOSIS DEVICE” and filed Mar. 9, 2020, the contents of which are incorporated herein by reference in their entirety.The present invention generally relates to a robotic surgical system for minimally invasive surgery. More particularly, the invention relates to an improved anastomosis device for the robotic surgical system.This section is intended to introduce the reader to various aspects of art that may be related to various aspects of the present disclosure, which are described below. This disclosure is believed to be helpful in providing the reader with background information to facilitate a better understanding of the various aspects of the present disclosure. Accordingly, it should be understood that these statements are to be read in this light, and not just as admissions of prior art.Robotically assisted surgical systems have been adopted worldwide to replace conventional surgical procedures to reduce amount of extraneous tissue(s) that may be ...

Apparatus For Delivering Gas and Illumination Source for Generating High Harmonic Radiation

Disclosed is gas delivery system which is suitable for a high harmonic generation (HHG) radiation source which may be used to generate measurement radiation for an inspection apparatus. In such a radiation source, a gas delivery element delivers gas in a first direction. The gas delivery element has an optical input and an optical input, defining an optical path running in a second direction. The first direction is arranged relative to the second direction at an angle that is not perpendicular or parallel. Also disclosed is a gas delivery element having a gas jet shaping device, or a pair of gas delivery elements, one of which delivers a second gas, such that the gas jet shaping device or second gas is operable to modify a flow profile of the gas such that the number density of the gas falls sharply. 1. A gas delivery system for use in an illumination source , comprising a gas delivery element arranged to direct gas in at least a first direction , wherein the gas delivery element comprises:an optical input; andan optical output,wherein the input and the output define an optical path, the optical path being oriented in a second direction, andwherein the second direction is non-perpendicular and non-parallel to the first direction.2. A gas delivery system according to claim 1 , wherein the first direction is at an obtuse angle relative to the second direction.3. A gas delivery system according to or claim 1 , wherein the optical input and optical output are arranged to allow pump radiation to pass through the gas to generate high harmonic radiation.4. A gas delivery system according to claim 3 , wherein the optical input and optical input are arranged concentrically with the optical path.5. A gas delivery system according to or claim 3 , wherein the optical input comprises an opening in a first wall of the gas delivery system claim 3 , and wherein the optical output comprises an opening in an opposing wall of the gas delivery system.6. A gas delivery system according ...

MOTORIZED SURGICAL INSTRUMENT

In one embodiment of the invention, a motorized surgical instrument including an elongated shaft, a wrist member and a pair of working members with at least one working member moveable relative to other working member between open and closed position, is presented. The elongate shaft includes towards its proximal end a carriage plate that enables independent and controlled motion of the surgical instrument employing plurality of actuators securely held therein. Further, disclosed is a surgical instrument enabling easy and quick replacement of working members. 1. A surgical instrument comprising:a longitudinal shaft having shaft axis defining a proximal end and a distal end, said shaft configured to be rotatable about the shaft axis;a wrist member coupled to the distal end of the shaft by a pivotal connection defining a wrist axis, said wrist member being angularly displaceable about the wrist axis by at least two wrist member-moving actuators operatively coupled to a single continuous wrist member-moving elongate element such that selective pulling of one end of the elongate element causes concomitant movement of the wrist member therewith in one direction while counter-pulling causes movement of the wrist member in opposed other direction; anda first working member and a second working member coupled by a common pivotal connection to working end of the wrist member to define working member axis, and configured to be displaced angularly about the working member axis when independently actuated respectively by first working member-moving actuator coupled with corresponding first working member-moving elongate element or second working member-moving actuator coupled with corresponding second working member-moving elongate element.2. The surgical instrument of claim 1 , wherein the wrist axis is substantially perpendicular to shaft axis thereby permitting the wrist member to rotate relative to the shaft axis around two substantially orthogonal axis.3. The surgical ...

MINIMALLY INVASIVE SURGICAL CANNULA

The present invention is directed to a minimally invasive surgical cannula provided with at least two grooves having a semi-circular profile as a non rotating feature. The non rotating grooves of cannula further accommodates at least one sensor and a strain gauge to detect and measure forces acting on cannula when it is coupled with a modular interfacing arrangement and facilitates maneuvering of surgical instrument inside the body cavity during surgical incision. 1) A cannula having a proximal and a distal end with the proximal end bearing an anti-rotation configuration comprising at least two grooves having a non-circular profile such that a flat surface is defined therebetween closing ends of each groove thereby interrupting an otherwise smooth and continuous circumferential profile of cannula to prevent said cannula from rotating and moving axially when in locked position during surgical insertion.2) The cannula of claim 1 , wherein the flat surface defined between closing end of each groove further forms thereupon a narrow slit to accommodate at least in part one sensor to detect if the cannula is securely engaged with a robotic arm and surgical instrument connecting interfacing arrangement.3) The cannula of claim 2 , wherein the narrow slit may further accommodate at least in part a strain gauge to measure force exerted on the cannula by the interfacing arrangement engageable therewith.4) The cannula of claim 2 , wherein the slit is formed to pierce only through a relatively small thickness of cannula wall claim 2 , preferably between 0.045 to 0.095 inches.5) A coupling arrangement including a connector coupling cannula with an interfacing arrangement claim 2 , and comprising:a central support member having disposed therewithin a resilient member configured to share an abutting relation with a pair of support member wings extending rearward from the support member towards the interfacing arrangement, said support member further extending in a frontal direction ...

Apparatus for delivering gas and illumination source for generating high harmonic radiation

Disclosed is gas delivery system which is suitable for a high harmonic generation (HHG) radiation source which may be used to generate measurement radiation for an inspection apparatus. In such a radiation source, a gas delivery element delivers gas in a first direction. The gas delivery element has an optical input and an optical input, defining an optical path running in a second direction. The first direction is arranged relative to the second direction at an angle that is not perpendicular or parallel. Also disclosed is a gas delivery element having a gas jet shaping device, or a pair of gas delivery elements, one of which delivers a second gas, such that the gas jet shaping device or second gas is operable to modify a flow profile of the gas such that the number density of the gas falls sharply.

Apparatus for delivering gas

A lithographic apparatus is a machine that applies a desired pattern onto a substrate, usually onto a target portion of the substrate. To ensure consistent quality of the patterns, metrology is used for process control and verification. In order to resolve smaller structures, the frequency of the radiation used in metrology is increased. One such method of generating suitably high frequency radiation is by using a high harmonic generation (HHG) radiation source. In such a radiation source, a gas delivery element (702) delivers gas (704) in a first direction (703). The gas delivery element has an optical input (706) and an optical output (708), defining an optical path (710) running in a second direction. The first direction is arranged relative to the second direction at an angle (724) that is not perpendicular or parallel.

Protein panels for the early diagnosis/prognosis and treatment of aggressive prostate cancer

Disclosed herein are methods of diagnosing or prognosing aggressive prostate cancer in a subject and methods of treating a subject with aggressive prostate cancer. For example, the methods can include measuring increased expression of aggressive prostate cancer-related molecules (such as FOLH1, SPARC, TGFB1, CAMKK2, NCOA2, EGFR, or PSA) and optionally administering a therapeutically effective amount of aggressive prostate cancer therapy.

A pressure control valve, a fluid handling structure for lithographic apparatus and a lithographic apparatus

Substituted benzimidazoles and their use for inducing apoptosis

The invention relates to compounds of formula (I), wherein R represents aryl or heteroaryl, X is a bond, a carbonyl group, a derivative of a carbonyl group, an ethylene group or an ethylenecarbonyl group, R1 is optionally substituted amino or hydroxy, and the substituents R2 to R6 have the meanings given in the specification, to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to intermediates, to the use of a compounds of formula (I) as a medicament and for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same.

Modular interface for a robotic system

The disclosure is directed to a medical robotic system and method for releasably securing a medical instrument over a modular support assembly that is further removably coupled to the manipulating arm via an intermediate fastening component. The medical instrument is configured for delivery through a small percutaneous penetration in a patient as it slides over the modular support assembly, independent of the manipulating arm. The robotic system further includes a simplified draping mechanism including covering the manipulating arm up to the fastening component thereby obviating the need for extensive sterile drape that extends all over the arm up to the support interface and the cannula holding assembly in existing art. Advantageously, the present invention allows for a quick and simple installation while allowing for free rotary motion of the support assembly.

A Level Sensor and a Lithographic Apparatus incorporating a Level Sensor

A level sensor system having a pneumatic sensor, a temperature sensor and a controller. The pneumatic sensor has a reference outlet for forming a reference gap with a reference surface and a measurement outlet for forming a measurement gap with a measurement surface, wherein the pneumatic 5 sensor is configured to make a pneumatic sensor measurement indicative of a difference between a flow of gas out of the reference outlet and a flow of gas out of the measurement outlet. The temperature sensor is configured to make a temperature measurement indicative of a temperature of the reference surface and/or a temperature of the measurement surface. The controller is configured to adjust the pneumatic sensor measurement based on the temperature measurement to generate a signal indicative of a difference 10 in height between the reference gap and the measurement gap. [FIG. 2]

An anastomosis device

An Anastomosis Device is intended to create an end-to-side anastomosis between a graft vessel and a target vessel. The anastomosis is created by the delivery of staples that connect the graft vessel to the target vessel and the creation of an incision to open a flow path between the graft vessel and the target vessel.

Substituted benzimidazoles and their use for inducing apoptosis

The invention relates to compounds of formula (I), wherein R represents aryl or heteroaryl, X is a bond, a carbonyl group, a derivative of a carbonyl group, an ethylene group or an ethylenecarbonyl group, R1 is optionally substituted amino or hydroxy, and the substituents R2 to R6 have the meanings given in the specification, to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to intermediates, to the use of a compounds of formula (I) as a medicament and for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same.

Modular interface for a robotic system

The disclosure is directed to a medical robotic system and method for releasably securing a medical instrument over a modular support assembly that is further removably coupled to the manipulating arm via an intermediate fastening component. The medical instrument is configured for delivery through a small percutaneous penetration in a patient as it slides over the modular support assembly, independent of the manipulating arm. The robotic system further includes a simplified draping mechanism including covering the manipulating arm up to the fastening component thereby obviating the need for extensive sterile drape that extends all over the arm up to the support interface and the cannula holding assembly in existing art. Advantageously, the present invention allows for a quick and simple installation while allowing for free rotary motion of the support assembly.

A combination kit used in the treatment of malaria

A combination kit for the treatment of malaria caused by Plasmodium vivax (P. vivax) having individual doses of an anti-malarial agent, 3-[1-[[4-[(6-methoxy-8-quinolinyl)amino]pentyl]amino]ethylidene]-dihydro-2(3H)-furanone (I) in the form of capsules; individual doses of the anti-malarial agent, chloroquine in the form of tablets; and instruction material for the administration of the two anti-malarial drugs. The combination kit is particularly suited for a 6 days treatment regimen where the treatment is rendered by five tablets containing 500 mg of chloroquine phosphate (equivalent to 300 mg base), three to be taken on day one and one each on days two and three; and five capsules containing 25 mg of 3-[1-[[4-[(6-methoxy-8-quinolinyl)amino]pentyl]amino]ethylidene]-dihydro-2(3H)-furanone (I), one each to be taken on days two to six.

Aroylfuranes and aroylthiophenes

The invention relates to compounds of formula (II) wherein ring A is a phenyl, pyridine, pyrimidine or pyrazine ring, W and X are carbon or nitrogen, Y is oxygen or sulfur, R 0 is different from hydrogen, R x is -(C=O)R 1 or cyano; R 1 is hydrogen, optionally substituted hydroxy or optionally substituted amino, and the other substituents are as described in the specification. The invention further relates to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (II), to the use of a compounds of formula (II) for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using compounds of formula (II) or pharmaceutical compositions containing same.

Modular interface for a robotic system

The disclosure is directed to a medical robotic system and method for releasably securing a medical instrument over a modular support assembly that is further removably coupled to the manipulating arm via an intermediate fastening component. The medical instrument is configured for delivery through a small percutaneous penetration in a patient as it slides over the modular support assembly, independent of the manipulating arm. The robotic system further includes a simplified draping mechanism including covering the manipulating arm up to the fastening component thereby obviating the need for extensive sterile drape that extends all over the arm up to the support interface and the cannula holding assembly in existing art. Advantageously, the present invention allows for a quick and simple installation while allowing for free rotary motion of the support assembly.

Furazanobenzimidazoles

The invention relates to compounds of formula (I) wherein R represents aryl or heteroaryl, X is oxygen, a carbonyl group, an oxime derivative of a carbonyl group or an .alpha.,.szlig.-unsaturated carbonyl group, and the substituents R1 to R6 have the meanings given in the specification, for use as medicaments, to novel compounds of formula (I), to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to the use of a compounds of formula (I) for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same.

A COMBINATION CASE USED IN THE TREATMENT OF PALUDISM REF. FTLL / 198

UN ESTUCHE DE COMBINACION PARA EL TRATAMIENTO DEL PALUDISMO PRODUCIDO PRO PLASMODIUM VIVAX (P.VIVAX), QUE TIENE DOSIS INDIVIDUALES DE UN AGENTE ANTIPALUDICO, 3-[1-[[4-[(6-METOXI-8-QUINOLINIL)AMINO]PENTIL]AMINO]ETILIDENO]-DIHIDRO-2-(3H)FURANONA (I) EN FORMA DE CAPSULAS; DOSIS INDIVIDUALES DEL AGENTE ANTIPALUDICO CLOROQUINA EN FORMA DE COMPRIMIDOS; Y MATERIAL DE INSTRUCCIONES PARA LA ADMINISTRACION DE LOS DOS FARMACOS ANTIPALUDICOS. EL ESTUCHE DE COMBINACION ES PARTICULARMENTE ADECUADO PARA UN REGIMEN DE TRATAMIENTO DE 6 DIAS, EN EL QUE EL TRATAMIENTO SE CONSIGUE MEDIANTE CINCO COMPRIMIDOS QUE CONTIENEN 500 MG DE FOSFATO DE CLOROQUINA (EQUIVALENTES A 300 MG DE BASE), DEBIENDO TOMARSE TRES EL DIA UNO Y UNO CADA UNO DE LOS DIAS DOS Y TRES; Y CONCO CAPSULAS QEU CONTIENEN 25 MG DE 3-[1-[[4-[(6-METOXI-8-QUINOLINIL)AMINO]PENTIL]AMINO]ETILIDENO]-DIHIDRO-2-(3H)FURANONA (I), DEBIENDO TOMARSE UNA CADA UNO DE LOS DIAS DOS A SEIS

Substituted benzimidazoles and their use for inducing apoptosis

The invention relates to compounds of formula (I), wherein R represents aryl or heteroaryl, X is a bond, a carbonyl group, a derivative of a carbonyl group, an ethylene group or an ethylenecarbonyl group, R1 is optionally substituted amino or hydroxy, and the substituents R2 to R6 have the meanings given in the specification, to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to intermediates, to the use of a compounds of formula (I) as a medicament and for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same.

Aryloxy- and arylthioxyacetophenone-type compounds for the treatment of cancer

The invention relates to compounds of formula (II) wherein ring A is a phenyl, pyridine, pyrimidine or pyrazine ring, W and X are carbon or nitrogen, Y is oxygen or sulfur, R 0 is different from hydrogen, R x is -(C=O)R 1 or cyano; R 1 is hydrogen, optionally substituted hydroxy or optionally substituted amino, and the other substituents are as described in the specification. The invention further relates to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (II), to the use of a compounds of formula (II) for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using compounds of formula (II) or pharmaceutical compositions containing same.

AROYLFURANE AND AROYLTHIOPHENE, SUITABLE FOR THE TREATMENT OF CANCER

Aroylfuranes and aroylthiophenes

The invention relates to compounds of formula (I) and of formula (II) wherein ring A is a phenyl, pyridine, pyrimidine or pyrazine ring, W and X are carbon or nitrogen, Y is oxygen or sulfur, R0 is different from hydrogen, Rx is -(C=O)R1 or cyano; R1 is hydrogen, optionally substituted hydroxy or optionally substituted amino, and the other substituents are as described in the specification. The invention further relates to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I) and of formula (II), to the use of compounds of formula (I) and of formula (II) for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using compounds of formula (I), of formula (II) or of pharmaceutical compositions containing same.

A system and method for virtual reality training, simulation of a virtual robotic surgery environment

The application provides a virtual reality system (200) and a method for simulating a virtual robotic surgery environment for providing training to medical professionals and diagnosis of any anomalies in the diagnostic scan of one or more patients. The virtual reality system (200) comprises an input device(202) configured to receive an input from an operator (204), and a processor (206) coupled to the input device (202) and configured to extract a relevant data (212) based on the received input, from a database (210) stored on a server (208) operably connected to the processor (206), wherein the server (208) is configured to store a database (210) including at least one of a diagnostic scan and patient details for one or more patients or a virtual tutorial for one or more robotic surgical procedures, render the relevant data (212) on a stereoscopic display (214) coupled to the processor (206), and manipulate the relevant data (212) based on another input received from the operator (204) and render the manipulated data on the stereoscopic display (214), to create a virtual robotic surgery environment.

A telescopic column assembly in a robotic arm system

A telescopic column assembly (213) for docking of a robotic arm at variable height in a robotic assisted surgery is disclosed herein. The telescopic column assembly (213) may include a plurality of spring assemblies (321), a rack and pinion assembly (323), a position sensor (325), and a motor (449). The plurality of spring assemblies (321) may be a constant spring such as (401), (403), (405), (407). The plurality of spring (401), (403), (405), (407) are wrapped to a plurality of drums (417), (419), (421), (423) and other ends of the plurality of springs (401), (403), (405), (407) are secured to a horizontal profile (433a) of the support member (433). The support member (433) is configured to move in vertical directions which is facilitated by the spring assemblies (321), the rack and pinion assembly (323) and the motor (449), to variably adjust the height of the surgical instruments while docking.

An ultrasonic surgical device

The application provides an ultrasonic surgical device (300) comprising of a proximal end (302) and a distal end (304) to be used in a robotic surgical system (100) The distal end (304) comprises of a first jaw (306) with an ultrasound 5 transducer array (310) and a second jaw (308) with either a reflecting surface (312) or an ultrasound transducer array (312). The distal end (304) is configured to grasp a blood vessel or a living tissue. The proximal end (302) is configured to apply a drive signal to the ultrasound transducer array (310), (312). A plurality of rotary joints is connected at the distal end (304) to facilitate its articulation. The ultrasound 10 transducer array (310), (312) is configured to generate acoustic vibrations in the grasped blood vessel, or living tissue, based on the applied drive signal by a control system of the robotic surgical system (100). The ultrasound transducer array (310), (312) is configured to sense parameters of a target site on a grasped blood vessel or living tissue, based on the reflected acoustic vibrations. The drive signal to the 15 ultrasound transducer array (310), (312) is manipulated based on the sensed parameters of the target site. The generated acoustic vibrations heat the target site in the blood vessel/living tissue for cutting or coagulation of the target site.

An articulating cannula

The application provides an articulating cannula (300) comprising a proximal end (302) and a distal end (304) connected with a hollow tubular shaft (306). The distal end (304) is configured to articulate between a first position (310) and a second position (312). The shaft (306) is segmented into a first shaft (414) and a second shaft (316) which are secured by a flexible material. The proximal end (302) comprises of a housing (308) having diameter substantially greater than the diameter of the shaft (306) and configured to allow insertion of an articulating surgical instrument (318). The second shaft (316) comprises of an outer layer (320) and an inner layer (322) of the flexible material with a compression spring (324) in between, the second shaft (316) is configured to facilitate the articulation of the distal end (304) and to prevent collapse of second shaft (316) at the distal end (304). The spring (324) is configured to maintain a constant cross section of the second shaft (316) with or without articulation.

A device for manually performing anastomosis

The present invention relates to a device for manually performing anastomosis between a graft vessel and a target vessel in order to bypass the blocked in coronary artery to restore adequate blood flow to the heart muscle. The manually operated configuration of the anastomosis device includes a handle (105) positioned at its distal end and an end-effector assembly (101) positioned at its proximal end. A shaft (103) one end is coupled to the handle (105) and the shaft (103) other end is coupled to the end-effector assembly (101). Further, a cable (223) is positioned within the shaft (103), wherein the cable (223) one end is secured to the handle (105) and the cable (223) other end is secured to the end-effector assembly (101) and the cable (223) facilitates in actuation of the end-effector assembly (101) to perform anastomosis.

Substituierte benzimidazole und deren verwendung zur induktion von apoptose

Aroylfurane und aroylthiophene, die sich für die behandlung von krebs eignen

Aryloxy- und arylthioxyacetophenon-verbindungen zur behandlung von krebs

Kit zur behandlung von malaria die chloroquin und bulaquin enthält

Heat flow control in a processing tool

An apparatus comprises an electrostatic chuck including a plate electrode and a column structure coupled with the plate electrode. A disk is coupled with the electrostatic chuck where the disk includes a first hole in a center of the disk and a second hole and a third hole distributed through the disk, where a portion of the column structure extends through the first hole. The apparatus further includes retention structures, wherein the retention structures individually include a shaft and a nut coupled with the shaft and the disk. The shaft extends through the second hole or the third hole and couples with a surface of the plate electrode.

A telescopic column assembly in a robotic arm system

A telescopic column assembly (213) for docking of a robotic arm at variable height in a robotic assisted surgery is disclosed herein. The telescopic column assembly (213) may include a plurality of spring assemblies (321), a rack and pinion assembly (323), a position sensor (325), and a motor (449). The plurality of spring assemblies (321) may be a constant spring such as (401), (403), (405), (407). The plurality of spring (401), (403), (405), (407) are wrapped to a plurality of drums (417), (419), (421), (423) and other ends of the plurality of springs (401), (403), (405), (407) are secured to a horizontal profile (433a) of the support member (433). The support member (433) is configured to move in vertical directions which is facilitated by the spring assemblies (321), the rack and pinion assembly (323) and the motor (449), to variably adjust the height of the surgical instruments while docking.

Furazanobenzimidazole

A multi-arm robotic surgical system

A multi-arm robotic surgical system (100) having an endoscopic camera (C) coupled to a robotic arm (102a) and a plurality of surgical instruments (302, 304, 306, 308) each detachably coupled to a robotic arm (102b, 102c, 102d, 102e). The 5 multi-arm robotic surgical system (100) further comprises of a surgeon console (400) having a master controller (402), a left-hand controller (404) and a right-hand controller (406), a three-dimensional (3D) HD monitor (408), a two-dimensional (2D) touch screen monitor (410), a pair of trackable 3D glasses (414) to be worn by the surgeon, a head tracking camera (412), a foot pedal controller (416), a control 10 panel (418) for performing emergency system functions, an electrosurgical unit interface (502), an image processor (504) configured to process a 3D image data received from the endoscopic camera (C), a digital device (506) configured to prepare an image data by using the processed 3D image data received from the image processor (504) and superimposing it with a 2D overlay including a status of 15 the plurality of surgical instruments (302, 304, 306, 308) and display on the 3D HD monitor (408) and a patient side staff 3D monitor (508).

Gugulipid zur behandlung von kognitiven störungen

[UNK]

[UNK]

An ultrasonic surgical device

The application provides an ultrasonic surgical device (300) comprising of a proximal end (302) and a distal end (304) to be used in a robotic surgical system (100) The distal end (304) comprises of a first jaw (306) with an ultrasound 5 transducer array (310) and a second jaw (308) with either a reflecting surface (312) or an ultrasound transducer array (312). The distal end (304) is configured to grasp a blood vessel or a living tissue. The proximal end (302) is configured to apply a drive signal to the ultrasound transducer array (310), (312). A plurality of rotary joints is connected at the distal end (304) to facilitate its articulation. The ultrasound 10 transducer array (310), (312) is configured to generate acoustic vibrations in the grasped blood vessel, or living tissue, based on the applied drive signal by a control system of the robotic surgical system (100). The ultrasound transducer array (310), (312) is configured to sense parameters of a target site on a grasped blood vessel or living tissue, based on the reflected acoustic vibrations. The drive signal to the 15 ultrasound transducer array (310), (312) is manipulated based on the sensed parameters of the target site. The generated acoustic vibrations heat the target site in the blood vessel/living tissue for cutting or coagulation of the target site.

Multi-fire clip applier instrument

The present invention discloses a surgical instrument, such as a clip applier which can be configured to apply one or more clips to a vessel located within a surgical site in the patient. The clip applier can be structured and arranged to position a clip relative to the vessel in order to compress the vessel within the clip. The clip applier can be configured to deform the clip within the jaws. The end effector of the clip applier can include a replaceable clip cartridge.

A hand controller for a robotic surgical system

A hand controller assembly (200) of a console system (105) is disclosed herein. The hand controller assembly may include a backend assembly (209), where the backend assembly (209) or (301) is configured to facilitate movement of the hand controller (207b) in x, y, and z- coordinate axes. The hand controller assembly (200) further includes a left-hand controller (201a) and a right-hand controller (201b). The left and-controller (201a) includes a plurality of link members (211a) coupled to one another to form a linkage and the right-hand controller (201b) includes a plurality of link members (211b) coupled to one another to form a linkage. Proximal end of the plurality of link members (211a), (211b) is operationally secured to the backend assembly (209) and distal of the plurality of link member (211a), (211b) is operationally secured to a gimbal assembly (213a), (213b) respectively. A dovetail mount (219) is secured to a mounting plate (217c), wherein the dovetail mount (219) is configured to releasably secure the hand controller assembly (200) in the console system (105).

System and method for virtual reality training, simulation of a virtual robotic surgery environment

The application provides a virtual reality system (200) and a method for simulating a virtual robotic surgery environment for providing training to medical professionals and diagnosis of any anomalies in the diagnostic scan of one or more patients. The virtual reality system (200) comprises an input device(202) configured to receive an input from an operator (204), and a processor (206) coupled to the input device (202) and configured to extract a relevant data (212) based on the received input, from a database (210) stored on a server (208) operably connected to the processor (206), wherein the server (208) is configured to store a database (210) including at least one of a diagnostic scan and patient details for one or more patients or a virtual tutorial for one or more robotic surgical procedures, render the relevant data (212) on a stereoscopic display (214) coupled to the processor (206), and manipulate the relevant data (212) based on another input received from the operator (204) and render the manipulated data on the stereoscopic display (214), to create a virtual robotic surgery environment.

A multi-arm robotic surgical system

A multi-arm robotic surgical system (100) having an endoscopic camera (C) coupled to a robotic arm (102a) and a plurality of surgical instruments (302, 304, 306, 308) each detachably coupled to a robotic arm (102b, 102c, 102d, 102e). The 5 multi-arm robotic surgical system (100) further comprises of a surgeon console (400) having a master controller (402), a left-hand controller (404) and a right-hand controller (406), a three-dimensional (3D) HD monitor (408), a two-dimensional (2D) touch screen monitor (410), a pair of trackable 3D glasses (414) to be worn by the surgeon, a head tracking camera (412), a foot pedal controller (416), a control 10 panel (418) for performing emergency system functions, an electrosurgical unit interface (502), an image processor (504) configured to process a 3D image data received from the endoscopic camera (C), a digital device (506) configured to prepare an image data by using the processed 3D image data received from the image processor (504) and superimposing it with a 2D overlay including a status of 15 the plurality of surgical instruments (302, 304, 306, 308) and display on the 3D HD monitor (408) and a patient side staff 3D monitor (508).

Gugulipid zur Behandlung von kognitiven Störungen

A system and method for obtaining kinematics of a robotic cart in a multi-arm robotic surgical system

The application provides a multi-arm robotic surgical system (100) and a 5 method (500) for obtaining kinematics of a plurality of robotic carts (SL, PL, PR, SR) with respect to a frame of reference (F). The system comprises of a laser module (122, 124, 126, 128) and a transmitter (130, 132, 134, 136) coupled to each of the plurality of robotic carts (SL, PL, PR, SR). The laser module (122, 124, 126, 128) is configured to generate a laser line (L) associated with each of 10 the plurality of robotic carts (SL, PL, PR, SR). The transmitter (130, 132, 134, 136) is configured to encode values of angles between the generated laser line (L) associated with each of the plurality of robotic carts (SL, PL, PR, SR) and the frame of reference (F). A master controller (106) is operatively coupled to the plurality of robotic carts (SL, PL, PR, SR) and configured to calculate the 15 kinematics of the plurality of robotic carts (SL, PL, PR, SR) with respect to the frame of reference (F), based on the encoded values of the angles.

A hand controller for a robotic surgical system

A hand controller assembly ( 200 ) of a console system ( 105 ) is disclosed herein. The hand controller assembly may include a backend assembly ( 209 ), where the backend assembly ( 209 ) or ( 301 ) is configured to facilitate movement of the hand controller ( 207 b ) in x, y, and z-coordinate axes. The hand controller assembly ( 200 ) further includes a left-hand controller ( 201 a ) and a right-hand controller ( 201 b ). The left and-controller ( 201 a ) includes a plurality of link members ( 211 a ) coupled to one another to form a linkage and the right-hand controller ( 201 b ) includes a plurality of link members ( 211 b ) coupled to one another to form a linkage. Proximal end of the plurality of link members ( 211 a ), ( 211 b ) is operationally secured to the backend assembly ( 209 ) and distal of the plurality of link member ( 211 a ), ( 211 b ) is operationally secured to a gimbal assembly ( 213 a ), ( 213 b ) respectively. A dovetail mount ( 219 ) is secured to a mounting plate ( 217 c ), wherein the dovetail mount ( 219 ) is configured to releasably secure the hand controller assembly ( 200 ) in the console system ( 105 ).

Protein panels for the early diagnosis/prognosis and treatment of aggressive prostate cancer

Verwendung von Primaquinederivaten zum behandlung von Malaria

Pre-operative planning for a multi-arm robotic surgical system

The application provides a method (700) for pre-operative planning for a multi-arm robotic surgical system (100) comprising surgical instruments (110, 112, 114, 116) coupled to robotic arms (102b, 102c, 102d, 102e), and a camera (C) coupled to robotic arm (102a). Each robotic arm is mounted on one of a plurality of robotic carts (SL, PL, CA, PR, SR) arranged along an operating table (104) and a patient lying on the operating table (104). The method (700) comprises storing (702) at least one of various human anatomical data and body habitus in a database (304) of a server (302). Then, the server (302) creates (704) a set of models indicating placement of ports on the body of the patient. A graphical user interface (GUI) (306) receives (706) the required patient data and details of a surgical procedure to be performed as input. A processor (308) analyzes (708) the received input with respect to the set of models and identifies (710) an appropriate model. The location of each robotic cart is detected (712) and displayed (714). An optimum configuration of each of the robotic arms and a desired location of each of the plurality of robotic carts is calculated (716). The plurality of robotic carts is placed (718) at the desired location of the plurality of robotic carts having the optimum configuration of each of the robotic arm. The distal end of the plurality of robotic arms is manipulated (720) and docked (722) according to the identified optimum placement of ports on the body of the patient.

A system and method for obtaining kinematics of a robotic cart in a multi-arm robotic surgical system

The application provides a multi-arm robotic surgical system (100) and a 5 method (500) for obtaining kinematics of a plurality of robotic carts (SL, PL, PR, SR) with respect to a frame of reference (F). The system comprises of a laser module (122, 124, 126, 128) and a transmitter (130, 132, 134, 136) coupled to each of the plurality of robotic carts (SL, PL, PR, SR). The laser module (122, 124, 126, 128) is configured to generate a laser line (L) associated with each of 10 the plurality of robotic carts (SL, PL, PR, SR). The transmitter (130, 132, 134, 136) is configured to encode values of angles between the generated laser line (L) associated with each of the plurality of robotic carts (SL, PL, PR, SR) and the frame of reference (F). A master controller (106) is operatively coupled to the plurality of robotic carts (SL, PL, PR, SR) and configured to calculate the 15 kinematics of the plurality of robotic carts (SL, PL, PR, SR) with respect to the frame of reference (F), based on the encoded values of the angles.

Method for the treatment of malaria by the use of primaquine derivative n1-(3-ethylidinotetrahydrofuran-2-one) -n 4-(6-methoxy-8-quinolinyl)-1,4-pentanediamine as gametocytocidal agent

The present invention a novel use of primaquine derivative N 1 -(3-ethylidinotetrahydrofuran-2-one)-N 4 -(6-methoxy-8-quinolinyl)-1,4-pentanediamine in the treatment and contolling the spread of malaria. In particular, the present invention discloses a method of treatment of malaria by the use of primaquine derivative N 1 -(3-ethylidinotetrahydrofuran-2-one)-N 4 -(6-methoxy-8-quinolinyl)-1,4-pentanediamine as a gametocytocidal agent.

A portable mixed reality surgeon console for minimally invasive surgery

The application provides a mixed reality surgeon console system (106) for a multi-arm robotic surgical system (100). The surgeon console system (106) comprises a chair (112) on which a surgeon (110) can be seated, a hand gripper assembly (120) secured to the chair (112), the hand gripper assembly (120) includes a left-hand gripper (120a) and a right-hand gripper (120b) and a pair of sensors (116) attached to each, a headset holder (124) connected to the chair (112) and configured to secure a mixed reality headset (128). A foot pedal tray (122) connected to the chair (112) and configured to move inward and outward directions, a control unit (132), a transmitter (118) coupled to the pair of sensors (116), the transmitter configured to send surgeon input to the robotic surgical instruments.

Pre-operative planning for a multi-arm robotic surgical system

The application provides a method (700) for pre-operative planning for a multi-arm robotic surgical system (100) comprising surgical instruments (110, 112, 114, 116) coupled to robotic arms (102b, 102c, 102d, 102e), and a camera (C) coupled to robotic arm (102a). Each robotic arm is mounted on one of a plurality of robotic carts (SL, PL, CA, PR, SR) arranged along an operating table (104) and a patient lying on the operating table (104). The method (700) comprises storing (702) at least one of various human anatomical data and body habitus in a database (304) of a server (302). Then, the server (302) creates (704) a set of models indicating placement of ports on the body of the patient. A graphical user interface (GUI) (306) receives (706) the required patient data and details of a surgical procedure to be performed as input. A processor (308) analyzes (708) the received input with respect to the set of models and identifies (710) an appropriate model. The location of each robotic cart is detected (712) and displayed (714). An optimum configuration of each of the robotic arms and a desired location of each of the plurality of robotic carts is calculated (716). The plurality of robotic carts is placed (718) at the desired location of the plurality of robotic carts having the optimum configuration of each of the robotic arm. The distal end of the plurality of robotic arms is manipulated (720) and docked (722) according to the identified optimum placement of ports on the body of the patient.