01-02-2018 дата публикации
Номер: US20180030060A1
The present invention provides a compound having the structure: 4. The compound of , or ,wherein{'sub': 1', '2', '3', '4', '5', '6', '3, 'R, R, R, R, Rand Rare each independently H, Cl, F, or CF.'}5. The compound of claim 4 ,wherein{'sub': 1', '3', '2', '3', '4', '5, 'Ris CF, Ris F, Ris F, Ris H, and Ris H, or'}{'sub': 1', '3', '2', '3', '4', '5, 'Ris CF, Ris F, Ris H, Ris H, and Ris H, or'}{'sub': 1', '3', '2', '3', '4', '5, 'Ris CF, Ris F, Ris H, Ris F, and Ris H, or'}{'sub': 1', '3', '2', '3', '4', '5, 'Ris CF, Ris H, Ris F, Ris F, and Ris H, or'}{'sub': 1', '3', '2', '3', '4', '5, 'Ris CF, Ris H, Ris H, Ris H, and Ris F, or'}{'sub': 1', '3', '2', '3', '4', '5, 'Ris CF, Ris H, Ris F, Ris H, and Ris H, or'}{'sub': 1', '3', '2', '3', '4', '5, 'Ris CF, Ris H, Ris H, Ris Cl, and Ris H, or'}{'sub': 1', '3', '2', '3', '4', '5, 'Ris CF, Ris Cl, Ris H, Ris H, and Ris H, or'}{'sub': 1', '2', '3', '3', '4', '3', '5, 'Ris H, Ris CF, Ris H, Ris CF, and Ris H, or'}{'sub': 1', '2', '3', '4', '5, 'Ris Cl, Ris H, Ris H, Ris F, and Ris H, or'}{'sub': 1', '2', '3', '4', '5, 'Ris Cl, Ris F, Ris H, Ris H, and Ris H.'}18. The compound of claim 17 ,{'sub': 8', '3, 'wherein each Ris CN or OCH.'}22. A pharmaceutical composition comprising the compound of any one of - and a pharmaceutically acceptable carrier.23. A method for treating a disease characterized by excessive lipofuscin accumulation in the retina in a subject afflicted therewith comprising administering to the subject an effective amount of a compound of any one of - or a composition of .24. The method of claim 23 , wherein the disease is further characterized by bisretinoid-mediated macular degeneration.25. The method of or claim 23 , wherein the amount of the compound is effective to lower the serum concentration of RBP4 in the subject.26. The method of any one of - claim 23 , wherein the amount of the compound is effective to lower the retinal concentration of a bisretinoid in lipofuscin in the subject.27. The method of ...
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