12-05-2022 дата публикации
Номер: US20220144821A1
Принадлежит:
The present invention discloses an AKT inhibitor, and specifically relates to a compound represented by formula I or a pharmaceutically acceptable salt thereof. The present invention further provides a preparation method thereof, and the use thereof in prevention and/or treatment of a disease mediated by AKT protein kinase. 2. The compound or pharmaceutically acceptable salts thereof according to claim 1 , wherein Ris selected from the group consisting of H claim 1 , OH claim 1 , and C-Calkyl optionally substituted by halogen or OH.3. The compound or pharmaceutically acceptable salts thereof according to claim 1 , wherein Rand Rare each independently selected from the group consisting of H claim 1 , C-Calkyl claim 1 , C-Ccycloalkyl claim 1 , (C-Ccycloalkyl)-(CH)— claim 1 , (C-Ccycloalkyl)-(CHCH)— claim 1 , benzyl claim 1 , phenethyl claim 1 , pyrrolidinyl and tetrahydropyranyl claim 1 , wherein the C-Calkyl claim 1 , C-Ccycloalkyl claim 1 , (C-Ccycloalkyl)-(CH)— or (C-Ccycloalkyl)-(CHCH)— is optionally substituted by F claim 1 , Cl claim 1 , Br claim 1 , I claim 1 , OH claim 1 , CN claim 1 , NHor C-Calkoxy claim 1 , the benzyl or phenethyl is optionally substituted by F claim 1 , Cl claim 1 , Br claim 1 , I claim 1 , OH claim 1 , OMe claim 1 , CFor Me claim 1 , the pyrrolidinyl or tetrahydropyranyl is optionally substituted by F claim 1 , Cl claim 1 , Br claim 1 , I claim 1 , OH claim 1 , C-Calkyl claim 1 , cyclopropylmethyl or C-Calkanoyl.6. The compound or pharmaceutically acceptable salts thereof according to claim 1 , wherein R claim 1 , R claim 1 , R claim 1 , and Rare each independently selected from the group consisting of H claim 1 , CN claim 1 , C-Calkyl and C-Calkoxy claim 1 , wherein the C-Calkyl or C-Calkoxy is optionally substituted by F claim 1 , Cl claim 1 , Br claim 1 , I claim 1 , OH claim 1 , CN or OMe.7. The compound or pharmaceutically acceptable salts thereof according to claim 1 , wherein Ris H or C-Calkyl claim 1 , wherein the C-Calkyl is ...
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