14-05-2020 дата публикации
Номер: US20200148666A1
Принадлежит:
The present invention relates to novel organic dinitroxide biradical compounds and their use as polarizing agents, in particular, in the techniques of Nuclear Magnetic Resonance (NMR) of solids or liquid samples and medical imaging. 5. The compound of formula (I) according to claim 1 , wherein Rand Rare joined claim 1 , through the double bond C═Xto form together with the nitrogen atom to which they are bound a 5- to 8-membered heterocyclic ring and which may contain an additional heteroatom or heteroatomic group selected from P(O)(OR) claim 1 , P(O)(R) claim 1 , O claim 1 , S claim 1 , N—O claim 1 , NH claim 1 , N(C-Calkyl) wherein the alkyl is straight claim 1 , branched or cyclic claim 1 , wherein the heterocyclic ring bears from one substituent to the maximum number of substituent on the carbon atoms and optionally contains one double bond;{'sub': '3', 'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'sup': 3', '4, 'with Xas defined in and with the proviso that the two groups Ror Rtogether do not contain more than one hydrogen alpha to the (N—O.) group.'}7. The compound of formula (I) according to claim 1 , wherein Xis O or —NRwherein Ris H; a substituted or unsubstituted claim 1 , linear claim 1 , branched or cyclic Calkyl group; —(CH) claim 1 , —COOH with n being an integer from 1 to 10 claim 1 , —(CH—CH—O)—CHor —(CH—CH—O)—H with m being an integer from 1 to 500 claim 1 , preferably from 1 to 100 claim 1 , more preferably from 1 to 10.8. The compound of formula (I) according to claim 1 , wherein Xis O or —NRwherein Ris H claim 1 , a linear or branched Calkyl claim 1 , —(CH—CH—O)—CHwith m being 1 to 10. The present invention relates to novel organic dinitroxide biradical compounds and their use as polarizing agents, in particular, in the techniques of Nuclear Magnetic Resonance (NMR) of solids or liquid samples and medical imaging.Nuclear magnetic resonance (NMR) is a very informative characterization method that allows probing matter by detecting signals of ...
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