OVERALL SYSTEM AND METHOD FOR DETECTING REGIONS OF INTEREST

A method of determining target heart ablation regions is provided which includes detecting electro-cardiogram (ECG) signals each indicating an electrical activity of a heart over time and determining, for each of the ECG signals, local activation times (LATs) each indicating a time of electrical activation for an area the heart. The method also includes generating, based on the LATs, electrical activity mapping information for displaying one or more maps representing the electrical activity of the heart and alternatively, or in addition to the electrical activity mapping information, generating spatio-temporal mapping information for one or more maps representing a spatio-temporal manifestation of the conditions indicative of cardiac arrhythmia, such as atrial fibrillation (AF). The method further includes determining a region of interest (ROI) of the heart by identifying the ROI as a region exhibiting conditions indicative of cardiac arrhythmia based on the mapping information. 1. A method of determining target heart ablation regions , the method comprising:detecting, via a plurality of sensors, a plurality of electro-cardiogram (ECG) signals, each ECG signal being detected via one of the plurality of sensors and indicating electrical activity of a heart over time;determining, for each of the plurality of ECG signals, a plurality of local activation times (LATs) occurring over time, each LAT indicating a time of electrical activation for an area the heart;generating, based on the determined plurality of LATs of each of the plurality of ECG signals, mapping information for one or more maps representing the electrical activity of the heart; anddetermining a region of interest (ROI) of the heart by identifying the ROI as a region of the heart exhibiting conditions indicative of cardiac arrhythmia based on the generated mapping information for the one or more maps representing the electrical activity of the heart.2. The method of claim 1 , wherein the ROI is identified ...

REGION OF INTEREST FOCAL SOURCE DETECTION USING COMPARISONS OF R-S WAVE MAGNITUDES AND LATs OF RS COMPLEXES

A system and method of identifying focal sources is presented. The method can comprise detecting, via sensors, electro-cardiogram (ECG) signals over time, each ECG signal detected via one of the sensors having a location in a heart and indicating electrical activity of the heart, each signal comprising at least an R wave and an S wave; creating an R-S map comprising an R-to-S ratio for each of the ECG signals, the R-to-S ratio comprising a ratio of absolute magnitude of the R wave to absolute magnitude of the S wave; identifying, for each of the ECG signals, local activation times (LATs); and correlating the R-to-S ratios for the ECG signals on the R-S map and the identified LATs and using the correlation to identify the focal sources. 1. A method of identifying focal sources , the method comprising:detecting, via a plurality of sensors, electro-cardiogram (ECG) signals over time, each ECG signal detected via one of the plurality of sensors having a location in a heart and indicating electrical activity of the heart, each signal comprising at least an R wave and an S wave;creating an R-S map comprising an R-to-S ratio for each of the plurality of ECG signals, the R-to-S ratio comprising a ratio of absolute magnitude of the R wave to absolute magnitude of the S wave;identifying, for each of the plurality of ECG signals, one or more local activation times (LATs); andcorrelating the R-to-S ratios for one or more of the plurality of ECG signals on the R-S map and the identified LATs and using the correlation to identify the focal sources.2. The method of claim 1 , the step of identifying one or more LATs further comprising:calculating a derivative for each of the R-S ratios; andidentifying an earliest activation LAT having largest negative value of the calculated derivative of the R-S ratio.3. The method of claim 2 , the step of creating the R-S map further comprising:determining, from the plurality of ECG signals, a strongest ECG signal having a largest difference ...

Chemically sintered composite electrodes and manufacturing processes

An iterative process of depositing on a solid electrolyte a coating of unconnected particles composed of an ionically conductive material. A liquid solution is also applied. The liquid solution includes an inorganic component. The deposited liquid is heated to a temperature sufficient to evaporate or otherwise remove some or all of the volatile components of the liquid solution. Typically the temperature is below 1000° and often at about 850° C. The effect of heating the solution is to cause ion conducting material in the solution to adhere to the surface of the existing ion conducting particles and form connections between these particles. This is understood to create an ion conducting skeletal support structure. Within the intrestices of this skeletal support structure, the step of heating is also understood to result in the deposition of the inorganic component that will begin to form a electron conducting structure. The process of applying the liquid solution and heating may be repeated until a sufficiently thick layer of material is laid over the solid electrolyte to provide the composite electrode structure desired.

REGION OF INTEREST FOCAL SOURCE DETECTION

A method of atrial focal source detection is provided which includes detecting, via sensors, electro-cardiogram (ECG) signals over time. Each ECG signal is detected via one of the sensors and indicates electrical activity of a heart. The method also includes determining, for each ECG signal, local activation times (LATs) each indicating a time of one of a plurality of atrial activations of a corresponding ECG signal and detecting whether one or more focal source areas of activation in the heart is indicated based on the detected ECG signals and the one or more local LATs. S-waves can be distinguished from non-S-waves by generating models for each atrial activation and classifying atrial activations. Maps can be generated by visually indicating, for each sensor, a level of incidence of the atrial activations occurring before atrial activations of neighboring sensors within a period of time. 1. A method of atrial focal source detection , the method comprising:detecting, via a plurality of sensors, electro-cardiogram (ECG) signals over time, each ECG signal detected via one of the plurality of sensors and indicating electrical activity of a heart;determining, for each of the plurality of ECG signals, local activation times (LATs) each indicating a time of one of a plurality of atrial activations of a corresponding ECG signal; anddetecting whether one or more focal source areas of activation in the heart is indicated based on the detected ECG signals and the one or more local LATs.2. The method of claim 1 , further comprising:generating, based on the detected one or more focal source areas of activation, mapping information of the detected one or more focal source areas of activation in the heart; andproviding the mapping information for one or more maps representing at least one of the electrical activity of the heart and the spatio-temporal manifestation of the electrical activity of the heart.3. The method of claim 2 , wherein providing the mapping information ...

REGION OF INTEREST ROTATIONAL ACTIVITY PATTERN DETECTION

A method of atrial rotational activity pattern (RAP) source detection is provided which includes detecting, via a plurality of sensors, electro-cardiogram (ECG) signals over time, each ECG signal detected via one of the plurality of sensors and indicating electrical activity of a heart. The method also includes determining, for each of the plurality of ECG signals, one or more local activation times (LATs) each indicating a time of activation of a corresponding ECG signal. The method further includes detecting whether one or more RAP source areas of activation in the heart is indicated based on the detected ECG signals and the one or more local LATs. Mapping information of the detected RAP source areas of activation in the heart is also generated for providing one or more maps. 1. A method of atrial rotational activity pattern (RAP) source detection , the method comprising:detecting, via a plurality of sensors, electro-cardiogram (ECG) signals over time, each ECG signal detected via one of the plurality of sensors and indicating electrical activity of a heart;determining, for each of the plurality of ECG signals, one or more local activation times (LATs) each indicating a time of activation of a corresponding ECG signal; anddetecting whether one or more RAP source areas of activation in the heart is indicated based on the detected ECG signals and the one or more local LATs.2. The method of claim 1 , further comprising:generating, based on the detected one or more RAP source areas of activation, mapping information of the detected one or more RAP source areas of activation in the heart; andproviding the mapping information for one or more maps representing at least one of the electrical activity of the heart and the spatio-temporal manifestation of the electrical activity of the heart.3. The method of claim 2 , further comprising providing RAP score information indicating a likelihood of the detection of the one or more RAP source areas of activation.4. The method of ...

9-SUBSTITUTED MINOCYCLINE COMPOUNDS

The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression. 2. The minocycline compound of claim 1 , wherein Ris NRR; X is CRR; R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R; and Rare each hydrogen; and claim 1 , R claim 1 , R claim 1 , R claim 1 , and R are each lower alkyl.3. The minocycline compound of claim 2 , wherein R claim 2 , R claim 2 , R claim 2 , and R are each methyl.4. A pharmaceutical composition comprising a therapeutically effective amount of a compound of and a pharmaceutically acceptable carrier. This application is a continuation application of U.S. Ser. No. 12/351,405, filed on Jan. 9, 2009, allowed, which is a continuation application of U.S. Ser. No. 12/128,379, filed on May 28, 2008, abandoned, which is a continuation application of U.S. Ser. No. 10/839,023, filed on May 4, 2004, now U.S. Pat. No. 8,048,867, which is a divisional application of U.S. Ser. No. 09/895,857, filed on Jun. 29, 2001, now U.S. Pat. No. 6,846,939, which claims priority to U.S. Ser. No. 60/275,621, filed on Mar. 13, 2001, and U.S. Ser. No. 60/216,659, filed on Jul. 7, 2000, the entire contents of each of which are incorporated herein by reference.The development of the tetracycline antibiotics was the direct result of a systematic screening of soil specimens collected from many parts of the world for evidence of microorganisms capable of producing bacteriocidal and/or bacteriostatic compositions. The first of these novel compounds was introduced in 1948 under the name chlortetracycline. Two years later, oxytetracycline became available. The elucidation of the chemical structure of ...

SYSTEM AND METHOD FOR AUTOMATED PLANNING OF NEXT GENERATION TELECOM NETWORK

The present disclosure provides the planning of the next generation network which complements an existing telecom deployment to achieve the desired KPIs from the combined network for both macro and small cell planning in an existing network in a cost-effective method to deploy ODSC cells and Macro Cells in a heterogeneous network. Planning a next-generation network for an existing telecom operator is a large undertaking, utilizing precious man-hours and most importantly, weeks of work. Using an automated planning methodology to plan macro and small cells for a region like a city, state or even country, planners can deploy solutions to make the most optimum use of existing infrastructure. The invention proposes an automated approach to plan the preferred overlay telecom solutions in an area A being part of an existing telecom deployment. 1. A system facilitating telecom overlay deployment in an area , said system comprising:a plurality of user equipment operatively coupled to a network;a planning server comprising a processor that executes a set of executable instructions that are stored in a memory, upon which execution, the processor causes the system to:build a plurality of grids of a predefined size;extract a set of samples, wherein the extracted set of samples pertain to spatial measurement of the grids observed from the area; spatial measurement samples pertaining to latitude and longitude, traffic consumed, serving cell identifier, user handset categorization and cell capacity indicator.map the extracted set of samples onto the plurality of grids of; andbased on the mapped extracted samples and deployment criteria, determine one or more solution sets for each grid of the plurality of grids.2. The system as claimed in claim 1 , wherein size of the plurality of grids is configurable for a planning run and wherein a grid is identified by the latitude and longitude of centroid of the grid.3. The system as claimed in claim 1 , wherein the extracted set of samples ...

Gas turbine engine dual-wall hot section structure

A hot section part of a turbine engine configured to be exposed to hot gases includes a first wall, a second wall, a plurality of pedestals, a plurality of impingement cooling holes, and a plurality of effusion cooling passages. The walls are spaced apart to form an intervening cavity, and each pedestal extends through the intervening cavity. The impingement cooling holes extend through the second wall to admit a flow of cooling air into the intervening cavity. Each effusion cooling passage is associated with a different one of the plurality of pedestals and is disposed at a predetermined angle relative to its associated principal axis. A portion of the flow of cooling air admitted to the intervening cavity is directed through at least a portion of each of the plurality of pedestals and onto the first wall inner surface.

Plug resistant effusion holes for gas turbine engine

A combustor for a gas turbine engine includes a first liner having a first surface, a second surface opposite the first surface, and a wall having a thickness defined between the first surface and the second surface. The first liner defines a plurality of effusion cooling holes, and at least one of the effusion cooling holes includes an inlet section spaced apart from the first surface, and a converging section downstream of the inlet section. The inlet section and the converging section are each defined so as to be outside of the thickness. The at least one of the effusion cooling holes includes a metering section downstream of the converging section and a portion of the metering section is defined within the thickness. The at least one of the effusion cooling holes includes an outlet section downstream of the metering section. The outlet section is proximate to the second surface.

REGION OF INTEREST FOCAL SOURCE DETECTION USING COMPARISONS OF R-S WAVE MAGNITUDES AND LATs OF RS COMPLEXES

A system and method of identifying focal sources is presented. The method can comprise detecting, via sensors, electro-cardiogram (ECG) signals over time, each ECG signal detected via one of the sensors having a location in a heart and indicating electrical activity of the heart, each signal comprising at least an R wave and an S wave; creating an R-S map comprising an R-to-S ratio for each of the ECG signals, the R-to-S ratio comprising a ratio of absolute magnitude of the R wave to absolute magnitude of the S wave; identifying, for each of the ECG signals, local activation times (LATs); and correlating the R-to-S ratios for the ECG signals on the R-S map and the identified LATs and using the correlation to identify the focal sources. 1. A method comprising:acquiring, via a plurality of sensors, electro-cardiogram (ECG) signals over time, each ECG signal acquired via one of the plurality of sensors and representing electrical activity of one of a plurality of different areas of a heart, each ECG signal comprising at least an R wave and an S wave;determining local activation times (LATs) of each ECG signal, each LAT of a respective ECG signal corresponding to acquired electrical activity at a different point in time;identifying a plurality of LATs determined to be part of a same cardiac activation cycle;generating first mapping information for visually indicating, at locations on a local activation time (LAT) map for each ECG signal, a number of instances, during a period of time that includes multiple cardiac activation cycles, in which at least one of the plurality of LATS is an earliest LAT; andgenerating second mapping information for visually indicating, at locations on an R-S map corresponding to the same locations on the LAT map, sizes of R-to-S ratios for each ECG signal in the period of time that includes multiple cardiac activation cycles, each R-to-S ratio comprising a ratio of a magnitude of the R wave to a magnitude of the S wave,wherein, potential ...

Region of interest focal source detection

A method of atrial focal source detection is provided which includes detecting, via sensors, electro-cardiogram (ECG) signals over time. Each ECG signal is detected via one of the sensors and indicates electrical activity of a heart. The method also includes determining, for each ECG signal, local activation times (LATs) each indicating a time of one of a plurality of atrial activations of a corresponding ECG signal and detecting whether one or more focal source areas of activation in the heart is indicated based on the detected ECG signals and the one or more local LATs. S-waves can be distinguished from non-S-waves by generating models for each atrial activation and classifying atrial activations. Maps can be generated by visually indicating, for each sensor, a level of incidence of the atrial activations occurring before atrial activations of neighboring sensors within a period of time.

Transcription factor modulating compounds and methods of use thereof

Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.

Transcription factor modulating compounds and methods of use thereof

Transcription factor modulating compounds and methods of use thereof

Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.

Combustor for gas turbine engine and method of manufacture

A combustor for a gas turbine engine includes an outer liner having a first end interconnected to an opposite second end by an outer liner wall composed of a plurality of outer segments. The inner liner has a first inner end interconnected to an opposite second inner end by an inner liner wall composed of a plurality of inner segments. The outer liner wall and the inner liner wall define a combustion chamber, and each of the outer wall segments extend at an angle of at least 40 degrees relative to a longitudinal axis. The outer wall segments includes a first segment, a second segment that extends at a second angle relative to the first segment, which is less than a third angle defined between the second segment and a third segment and is substantially the same as a fourth angle defined between the third segment and a fourth segment.

Method, system and device for handling a memory management fault in a multiple processor device

A method or device handles memory management faults in a device having a digital signal processor (“DSP”) and a microprocessor. The DSP includes a memory management unit (“DSP MMU”) to manage memory access by the DSP, and the DSP and the microprocessor access shared physical memory. Upon the DSP executing an instruction attempting to access a virtual address wherein the virtual address is invalid, a page fault interrupt is generated by the DSP MMU. A microprocessor interrupt handler in the microprocessor is activated in direct response to the page fault interrupt. Thereafter in the microprocessor, a translation lookaside buffer (“TLB”) entry is created in the DSP MMU, which includes a valid mapping between the virtual address and a page of physical memory. After creating the TLB entry, the microprocessor indicates to the DSP that the access by the DSP of the virtual address is completed.

7-substituted tetracycline compounds

The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infectio ns and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.

9-substituted minocycline compounds

The present invention pertains, at least in part, to novel 9- substituted minocycline compounds. These minocyline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.

Tetracycline compounds for the treatment of rheumatoid arthritis and related methods of treatment.

Tetracycline compounds for the treatment of rheumatoid arthritis and related methods of treatment

The present invention pertains, at least in part, to substituted tetracycline compounds. The present invention also pertains to methods for treating rheumatoid arthritis in a subject, comprising administering to the subject a tetracycline compound of the invention.

Transcription factor modulating compounds and methods of use thereof

Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.

Transcription factor modulating compounds and methods of use thereof

Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.

9-REPLACED MINOCICLINE COMPOUNDS.

Un compuesto de minociclina de la fórmula I: En donde: R4'', R4", R7'' y R7" cada uno son alquilo (C1-5); y R9 es metilo que se sustituye con (a) un grupo de amino, (b) un grupo alquilamino (C1-6), (c) un grupo di (C1-6) alquilamino, o (d) un grupo alquilamino (C1-6)en el que el del grupo alquilamino (C1-6) se sustituye por fenilo, metilenedioxifenilo o para- perfluorometoxifenilo; Sales farmacéuticamente aceptables de estos, y prodrogas de estos en donde la porción de prodrogas se selecciona de porciones de éster de alquilo (C1-5), ésteres de alquenilo (C2-5), ésteres de di (C1-5) alquilamino (C1-5)-alquilo, ésteres de acilamino (C1-5) alquilo, ésteres de aciloxi (C1-5) alquilo, ésteres de arilo, ésteres de aril-(C1-5) alquilo, sustituido (con metilo, halo o sustituyentes metoxi), arilo y porciones de éster aril-(C1-5) alquilo, amidas (C1-5)-alquilo, amidas di-(C1-5) alquilo, y amidas hidroxi. A minocycline compound of the formula I: Where: R4 ", R4", R7 "and R7" each are (C1-5) alkyl; and R9 is methyl which is substituted with (a) an amino group, (b) an alkylamino (C1-6) group, (c) a di (C1-6) alkylamino group, or (d) an alkylamino (C1) group -6) in which that of the (C 1-6) alkylamino group is substituted by phenyl, methylenedioxyphenyl or para-perfluoromethoxyphenyl; Pharmaceutically acceptable salts thereof, and prodrugs thereof wherein the prodrug portion is selected from portions of alkyl ester (C1-5), alkenyl esters (C2-5), esters of di (C1-5) alkylamino (C1 -5) -alkyl, acylamino (C1-5) alkyl esters, acyloxy (C1-5) alkyl esters, aryl esters, aryl esters- (C1-5) alkyl, substituted (with methyl, halo or methoxy substituents ), aryl and portions of aryl- (C1-5) alkyl ester, (C1-5) -alkyl amides, di- (C1-5) alkyl amides, and hydroxy amides.

Tetracycline derivatives for the treatment of bacterial, viral and parasitic infections

The present invention pertains, at least in part, to a substituted tetracycline compound of Formula (I): wherein X is CHC(R13VY), CR6 R6, C=CR6 R6, S, NR6, or O; E is NR7dR7β, OR7f or (CH2)o.iC(=W)WR7s; W is O, S, NR711 or CR75R7*; W is O, S or NR7*; These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms.

Method and materials for bonding electrodes to interconnect layers in solid oxide fuel cell stacks

A method and related bonding compositions for use in assembling a solid oxide fuel cell ("SOFC") stack having thermally and chemically stable and electrically conductive bonds between alternating fuel cells and interconnect components in the stack. The improved method and materials allow for the assembly of solid oxide fuel cells having a stronger and more reliable bond with good electrical contact in situ between the SOFC interconnect layers (plates) and the electrodes. The bonding materials and method according to the invention provide good electrical performance while maintaining the mechanical and electrical integrity of SOFC stacks without requiring excessive mechanical compression of the stack as exemplified by prior art systems. The preferred bonding agents comprise a primary phase that provides the electrical conduction path during fuel cell operation, as well as the mechanical strength necessary to insure a reliable connection between the interconnect and the relevant anode or cathode surfaces of the fuel cell. Secondary phases can be added in small amounts to the primary phase to improve adhesion. An exemplary method according to the invention also contemplates various different steps for pre-treating the surfaces of the interconnect plates and electrodes to improve their surface bonding properties.

Transcription factor modulating compounds and methods of use thereof

Methods for identifying compound useful as anti-infectives that decreas e resistance, virulence, or growth of microbes are provided. In one embodiment , the method comprises contacting a microbial cell comprising: 1) a selectable marker under the control of a transcription factor responsive element and 2) a transcription factor, with a compound under conditions which allow interaction of the compound with the microbial cell; and measuring the ability of the compound to affect the grow th or survival of the microbial cell as an indication of whether the test compound modulates the activity of a transcription factor.

7-heterocyclyl substituted sancycline derivatives for treating bacterial, viral and parasitic infections (e.g. malaria) or inflammatory diseases

The present invention relates to tetracycline derivatives, and in particular to sancycline derivatives substituted at their 7-position by a five-membered heterocyclic ring, for use in the treatment of bacterial, viral and/or parasitic infections, such as e.g. malaria, and/or inflammatory diseases.

System and method for detecting atrial fibrillation focal sources

A method of atrial focal source detection is provided which includes detecting, via sensors, electro-cardiogram (ECG) signals over time. Each ECG signal is detected via one of the sensors and indicates electrical activity of a heart. The method also includes determining, for each ECG signal, local activation times (LATs) each indicating a time of one of a plurality of atrial activations of a corresponding ECG signal and detecting whether one or more focal source areas of activation in the heart is indicated based on the detected ECG signals and the one or more local LATs. S-waves can be distinguished from non-S-waves by generating models for each atrial activation and classifying atrial activations. Maps can be generated by visually indicating, for each sensor, a level of incidence of the atrial activations occurring before atrial activations of neighboring sensors within a period of time.

System and method for determining atrial fibrillation regions for ablation

A method of determining target heart ablation regions is provided which includes detecting electro-cardiogram (ECG) signals each indicating an electrical activity of a heart over time and determining, for each of the ECG signals, local activation times (LATs) each indicating a time of electrical activation for an area the heart. The method also includes generating, based on the LATs, electrical activity mapping information for displaying one or more maps representing the electrical activity of the heart and alternatively, or in addition to the electrical activity mapping information, generating spatio-temporal mapping information for one or more maps representing a spatio-temporal manifestation of the conditions indicative of cardiac arrhythmia, such as atrial fibrillation (AF). The method further includes determining a region of interest (ROI) of the heart by identifying the ROI as a region exhibiting conditions indicative of cardiac arrhythmia based on the mapping information.

7-substituted tetracycline compounds

The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.

DETECTION OF FOCAL SOURCES OF THE ATRIE FLIMMER

Identifying focal sources during atrial fibrillation

A system and method of identifying focal sources is presented. The method can comprise detecting, via sensors, electro-cardiogram (ECG) signals over time, each ECG signal detected via one of the sensors having a location in a heart and indicating electrical activity of the heart, each signal comprising at least an R wave and an S wave; creating an R-S map comprising an R-to-S ratio for each of the ECG signals, the R-to-S ratio comprising a ratio of absolute magnitude of the R wave to absolute magnitude of the S wave; identifying, for each of the ECG signals, local activation times (LATs); and correlating the R-to-S ratios for the ECG signals on the R-S map and the identified LATs and using the correlation to identify the focal sources.

9-substituted minocycline compounds

Un compuesto de minociclina que tiene la siguiente fórmula: **(Ver fórmula)** en la que: R4', R4", R7' y R7" son cada uno alquilo C1-C5; R9 es metilo, etilo, i-propilo, n-propilo, alquilo sustituido, alquinilo no sustituido o sustituido, alcoxi, alquiltio, alquilsulfinilo, alquilsulfonilo, arilalquilo, arilalquinilo, tionitroso, alquilamino no sustituido o sustituido o -(CH2)1- 3NR9cC(>=Z')ZR9a, en el que dicho alquilo sustituido está sustituido con uno o más sustituyentes seleccionados del grupo que consiste en halógeno, alquilcarboniloxi, arilcarboniloxi, alcoxicarboniloxi, ariloxicarboniloxi, alquilaminocarbonilo, arilalquilaminocarbonilo, alquenilaminocarbonilo, alquenilcarbonilo, sililo, aminocarbonilo, alquiltiocarbonilo, fosfato, fosfonato, fosfinato, acilamino, amidino, imino, sulfhidrilo, alquiltio, ariltio, tiocarboxilato, sulfato, alquilsulfinilo, sulfonato, sulfamoilo, sulfonamido, nitro, azido, heterociclilo, alquilarilo, fenilo y heteroarilo; Z es CR9d R9e, S, NR9b u O; Z' es NR9f, O o S; y R9a es hidrógeno, acilo, alquilo no sustituido o sustituido, alquenilo no sustituido o sustituido, alquinilo no sustituido o sustituido, alcoxi no sustituido o sustituido, alquiltio, alquilsulfinilo, alquilsulfonilo, alquilamino, arilalquilo, arilo no sustituido o sustituido, heterocíclico no sustituido o sustituido, heteroaromático no sustituido o sustituido; R9b, R9c, R9d, R9e y R9f son cada uno independientemente hidrogeno, acilo, alquilo, alquenilo, alquinilo, alcoxi, alquiltio, alquilsulfinilo, alquilsulfonilo, alquilamino, arilalquilo, arilo, heterocíclico, heteroaromático; o un compuesto de minociclina seleccionado de entre los siguientes: **(Ver fórmulas)** y **(Ver fórmula)** o una sal farmacéuticamente aceptable del mismo. A minocycline compound having the following formula: ** (See formula) ** wherein: R4 ', R4 ", R7' and R7" are each C1-C5 alkyl; R9 is methyl, ethyl, i-propyl, n-propyl, substituted alkyl, ...

Amino-methyl substituted tetracycline compounds

9-Substituted minocycline compounds

The present invention pertains, at least in part, to novel 9- substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.

Tetracycline derivatives for the treatment of bacterial, viral and parasitic infections

The present invention pertains, at least in part, to a substituted tetracycline compound of Formula (I): wherein X is CHC(R13VY), CR6 R6, C=CR6 R6, S, NR6, or O; E is NR7dR7β, OR7f or (CH2)o.iC(=W)WR7s; W is O, S, NR711 or CR75R7*; W is O, S or NR7*; These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms.

7-substituted tetracycline compounds

The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.

Substituted tetracycline compounds

tetracycline compounds for the treatment of rheumatoid arthritis and related treatment methods

Transcription factor modulating compounds and methods of use thereof

Substituted benziomidozole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benziomidazole compounds, as well as pharmaceutical preparations therefore, in, e.g., reducing antibiotic resistance and inhibiting biofilms.

Tetracycline derivatives for the treatment of bacterial, viral and parasitic infections

7-substituted tetracycline compounds.

Amino-methyl substituted tetracycline compounds

Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.

Substituted tetracycline compounds

The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.

9-substituted minocycline compounds

The present invention pertains, at least in part, to novel 9- substituted minocycline compounds. These minocyline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infectio ns and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline compounds i n general, such as blocking tetracycline efflux and modulation of gene expression.

Substituted tetracycline compounds.

La presente invención pertenece, al menos en parte, a un compuesto tetraciclina sustituida que tiene la fórmula (I): en donde X es CHC(R13VY), CR6 R6, C=CR6, S, NR6 u O; E es NR7dR7?, OR7f ó (CH2)o.iC(=W)WR7s; W es O, S, NR711 ó CR75R7*; W es O, S ó NR7*; estos compuestos tetaciclina pueden utilizarse para tratar numerosos estados sensibles a los compuestos tetraciclina, como pueden ser infecciones bacterianas y neoplasmas.

System and method for detecting atrial fibrillation rotational activity pattern sources

A method of atrial rotational activity pattern (RAP) source detection is provided which includes detecting, via a plurality of sensors, electro-cardiogram (ECG) signals over time, each ECG signal detected via one of the plurality of sensors and indicating electrical activity of a heart. The method also includes determining, for each of the plurality of ECG signals, one or more local activation times (LATs) each indicating a time of activation of a corresponding ECG signal. The method further includes detecting whether one or more RAP source areas of activation in the heart is indicated based on the detected ECG signals and the one or more local LATs. Mapping information of the detected RAP source areas of activation in the heart is also generated for providing one or more maps.

Transcription factor modulating compounds and methods of use thereof

Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.

Transcription factor modulating compounds and methods of use thereof

Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.

Transcription factor modulating compounds and methods of use thereof

Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.

9-substituted minocycline compounds

The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsible states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.

Substituted tetracycline compounds

The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.

Region of interest rotational activity pattern detection

A method of atrial rotational activity pattern (RAP) source detection is provided which includes detecting, via a plurality of sensors, electro-cardiogram (ECG) signals over time, each ECG signal detected via one of the plurality of sensors and indicating electrical activity of a heart. The method also includes determining, for each of the plurality of ECG signals, one or more local activation times (LATs) each indicating a time of activation of a corresponding ECG signal. The method further includes detecting whether one or more RAP source areas of activation in the heart is indicated based on the detected ECG signals and the one or more local LATs. Mapping information of the detected RAP source areas of activation in the heart is also generated for providing one or more maps.

9-substituted minocycline compounds

The present invention pertains, at least in part, to novel 9- substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.

Tetracycline compounds for the treatment of rheumatoid arthritis and related methods of treatment

Transcription factor modulating compounds and methods of use thereof

Tetracycline derivatives for the treatment of bacterial, viral and parasitic infections

細菌感染、ウイルス感染、および寄生虫感染の治療のためのテトラサイクリン誘導体

【課題】細菌感染、ウイルス感染、および寄生虫感染の治療のためのテトラサイクリン誘導体を提供すること。【解決手段】本発明は、少なくとも一部において、式（Ｉ）：（式中、Ｘは、ＣＨＣ（Ｒ１３Ｙ’Ｙ）、ＣＲ６’Ｒ６、Ｃ＝ＣＲ６’Ｒ６、Ｓ、ＮＲ６、またはＯであり；Ｅは、ＮＲ７ｄＲ７ｅ、ＯＲ７ｆまたは（ＣＨ２）０－１Ｃ（＝Ｗ’）ＷＲ７ｇであり；Ｗは、Ｏ、Ｓ、ＮＲ７ｈまたはＣＲ７ｉＲ７ｊであり；Ｗ’は、Ｏ、ＳまたはＮＲ７ｋである）の置換テトラサイクリン化合物に関する。これらのテトラサイクリン化合物は、数多くのテトラサイクリン化合物応答性状態、たとえば、細菌感染および新生物を治療するために使用することができる。TIFF2024009235000287.tif4163【選択図】なし

System for combined ablation modalities

The disclosed technology includes a method of ablating tissue including positioning an electrode into contact with tissue and applying a first ablation signal to the tissue. The method can include forming a first lesion comprising a first depth with little or no first temperature change in a temperature of the tissue. The method can include applying a second ablation signal to the tissue different from the first ablation signal. Applying the second ablation signal to the tissue can include forming a second lesion comprising a second depth and generating a second temperature change in the tissue different from the first temperature change by at least 10°C. The method can include forming a combined lesion comprising the first lesion and the second lesion and comprising a combined size. The combined depth can be about 20% to about 40% greater than either of the first depth and the second size.

Viral detection assays

Methods, compositions and kits for detection of one or more of Human Parvovirus B19 (B19), Human Herpes Virus 6 (HHV6), Human Herpes Virus 7 (HHV7), Human Herpes Virus 8 (HHV8), Epstein Barr Virus (EBV), and Hepatitis A Virus (HAV) in sample(s) are disclosed herein.

Non-overlapping loop-type catheter to determine activation source direction and activation source type

Catheter, system and method for combined ablation modalities

The disclosed technology includes a method of ablating tissue including positioning an electrode into contact with tissue and applying a first ablation signal to the tissue. The method can include forming a first lesion comprising a first depth with little or no first temperature change in a temperature of the tissue. The method can include applying a second ablation signal to the tissue different from the first ablation signal. Applying the second ablation signal to the tissue can include forming a second lesion comprising a second depth and generating a second temperature change in the tissue different from the first temperature change by at least 10° C. The method can include forming a combined lesion comprising the first lesion and the second lesion and comprising a combined size. The combined depth can be about 20% to about 40% greater than either of the first depth and the second size.

9-substituierte minocyclinverbindungen

System and method for detecting atrial fibrillation focal sources

System and method for detecting atrial fibrillation focal sources

System for detecting atrial fibrillation rotational activity pattern sources

Machine learning system for analyzing the quality and efficacy of essays for higher education admissions

Systems and methods for the multifaceted analysis of a written work, such as an educational program admission essay, using machine learning, deep learning and natural language processing. Language, relevance, structure, and flows are evaluated for an overall impactful essay. Essay content is checked to evaluate whether the author has covered an essay's essential aspects. The essay is also analyzed for an effective structure for presenting details as per the essay type. The disclosure includes data preparation for the task, process of data tagging, feature engineering from the essay text, method for transfer learning and fine-tuning language model to adapt to the context of an essay. Finally, a process for building machine learning and deep learning models and technique for ensembling to use both models in combination is disclosed. The system may provide user-adapted feedback based on a persona created from the user profile.

9-substituierte minocyclinverbindungen

Region of interest focal source detection using comparisons of R-S wave magnitudes and LATs of RS complexes

A system and method of identifying focal sources is presented. The method can comprise detecting, via sensors, electro-cardiogram (ECG) signals over time, each ECG signal detected via one of the sensors having a location in a heart and indicating electrical activity of the heart, each signal comprising at least an R wave and an S wave; creating an R-S map comprising an R-to-S ratio for each of the ECG signals, the R-to-S ratio comprising a ratio of absolute magnitude of the R wave to absolute magnitude of the S wave; identifying, for each of the ECG signals, local activation times (LATs); and correlating the R-to-S ratios for the ECG signals on the R-S map and the identified LATs and using the correlation to identify the focal sources.

Non-overlapping loop-type catheter to determine activation source direction and activation source type

System for determining atrial fibrillation regions for ablation

Deswirl system for gas turbine engine

A deswirl system for a gas turbine engine includes a deswirl shroud, and at least one deswirl vane having a leading end and a trailing end. The deswirl system includes a deswirl hub spaced apart from the deswirl shroud by the at least one deswirl vane. The deswirl hub includes a hub body that extends at a first angle and a hub extension that extends beyond the trailing end of the at least one deswirl vane. The hub extension extends from the hub body at a second angle, and the first angle is different than the second angle.

Catheter, system and method for combined ablation modalities

Solid Oxide Electrochemical Devices Having a Dimensionally Stable Bonding Agent to Bond an Anode to Anode Interconnect and Methods

A solid oxide electrochemical device having improved mechanical integrity comprising a bonding agent for physically and electrically bonding an anode to an anode interconnect, the bonding agent comprising a particulate metal, wherein the bonding agent is substantially chemically inert during operation of the solid oxide electrochemical device. A method for bonding an anode and an anode interconnect to be used in a solid oxide electrochemical device.

Plug resistant effusion holes for gas turbine engine

A combustor for a gas turbine engine includes a first liner having a first surface, a second surface opposite the first surface, and a wall having a thickness defined between the first surface and the second surface. The first liner defines a plurality of effusion cooling holes, and at least one of the effusion cooling holes includes an inlet section spaced apart from the first surface, and a converging section downstream of the inlet section. The inlet section and the converging section are each defined so as to be outside of the thickness. The at least one of the effusion cooling holes includes a metering section downstream of the converging section and a portion of the metering section is defined within the thickness. The at least one of the effusion cooling holes includes an outlet section downstream of the metering section. The outlet section is proximate to the second surface.

Plug resistant effusion holes for gas turbine engine

A combustor for a gas turbine engine includes a liner having a first surface, a second surface opposite the first surface, and defining a plurality of effusion cooling holes. At least one of the effusion cooling holes includes an inlet section and a converging section downstream of the inlet section. The at least one of the effusion cooling holes includes a metering section downstream of the converging section. The at least one of the effusion cooling holes includes an outlet section downstream of the metering section. The outlet section is proximate to the second surface. The inlet section, the converging section, the metering section and the outlet section extend along a longitudinal axis, with the inlet section asymmetrical relative to the longitudinal axis and the metering section symmetrical relative to the longitudinal axis.

Machine learning system for analyzing the quality and efficacy of essays for higher education admissions

Systems and methods for the multifaceted analysis of a written work, such as an educational program admission essay, using machine learning, deep learning and natural language processing. Language, relevance, structure, and flows are evaluated for an overall impactful essay. Essay content is checked to evaluate whether the author has covered an essay's essential aspects. The essay is also analyzed for an effective structure for presenting details as per the essay type. The disclosure includes data preparation for the task, process of data tagging, feature engineering from the essay text, method for transfer learning and fine-tuning language model to adapt to the context of an essay. Finally, a process for building machine learning and deep learning models and technique for ensembling to use both models in combination is disclosed. The system may provide user-adapted feedback based on a persona created from the user profile.

Transcription factor modulating compounds and methods of use thereof

Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.

Quality and efficacy analysis of statement of purpose in higher education admissions using machine learning

Systems and methods for the multifaceted analysis of a written work, such as an educational program admission essay, using machine learning, deep learning and natural language processing. Language, relevance, structure, and flows are evaluated for an overall impactful essay. Essay content is checked to evaluate whether the author has covered an essay's essential aspects. The essay is also analyzed for an effective structure for presenting details as per the essay type. The disclosure includes data preparation for the task, process of data tagging, feature engineering from the essay text, method for transfer learning and fine-tuning language model to adapt to the context of an essay. Finally, a process for building machine learning and deep learning models and technique for ensembling to use both models in combination is disclosed. The system may provide user-adapted feedback based on a persona created from the user profile.

Chemically sintered composite electrodes and manufacturing processes

An iterative process of depositing on a solid electrolyte a coating of unconnected particles composed of an ionically conductive material. A liquid solution is also applied. The liquid solution includes an inorganic component. The deposited liquid is heated to a temperature sufficient to evaporate or otherwise remove some or all of the volatile components of the liquid solution. Typically the temperature is below 1000° and often at about 850° C. The effect of heating the solution is to cause ion conducting material in the solution to adhere to the surface of the existing ion conducting particles and form connections between these particles. This is understood to create an ion conducting skeletal support structure. Within the intrestices of this skeletal support structure, the step of heating is also understood to result in the deposition of the inorganic component that will begin to form a electron conducting structure. The process of applying the liquid solution and heating may be repeated until a sufficiently thick layer of material is laid over the solid electrolyte to provide the composite electrode structure desired.

Chemically sintered composite electrodes and manufacturing processes

Electrodos compuestos químicamente sinterizados y procedimientos de fabricación

Un procedimiento para producir electrodos de pilas de combustible, comprendiendo el procedimiento: proporcionar (12) un sustrato (44, 94); y aplicar (14) una primera capa al sustrato, en el que la primera capa incluye una pluralidad de partículas individuales (42), caracterizado por aplicar (18) a la primera capa un líquido que tiene un componente inorgánico y un disolvente, de modo que el líquido cubre sustancialmente al menos una parte de cada partícula; y calentar (20) el líquido a una temperatura menor de aproximadamente 1000 grados Celsius, evaporar el disolvente y producir un recubrimiento (48) sobre las partículas que incluye el componente inorgánico.

Chemisch gesinterte verbundelektroden und herstellungsprozesse

Chemically sintered composite electrodes and manufacturing processes

An iterative process of depositing on a solid electrolyte a coating of unconnected particles composed of an ionically conductive material. A liquid solution is also applied. The liquid solution includes an inorganic component. The deposited liquid is heated to a temperature sufficient to evaporate or otherwise remove some or all of the volatile components of the liquid solution. Typically the temperature is below 1000 ° and often at about 850°C. The effect of heating the solution is to cause ion conducting material in the solution to adhere to the surface of the existing ion conducting particles and form connections between these particles. This is understood to create an ion conducting skeletal support structure. Within the intrestices of this skeletal support structure, the step of heating is also understood to result in the deposition of the inorganic component that will begin to form a electron conducting structure. The process of applying the liquid solution and heating may be repeated until a sufficiently thick layer of material is laid over the solid electrolyte to provide the composite electrode structure desired.

Gas turbine combustor with enhanced cooling features

A combustor for a gas turbine engine includes a combustor liner with a wall defining a combustion chamber. The wall has an inner surface facing the combustion chamber and an outer surface across the wall from the inner surface. Fins are disposed on the outer surface. The wall defines air admission holes that extend through the wall from the outer surface to the inner surface. The wall also defines film cooling holes that extend through the wall from the outer surface to the inner surface. The fins are disposed in areas of the outer surface between the film cooling holes and the air admission holes to cool areas that would otherwise result in hot spots.