09-12-2021 дата публикации
Номер: US20210379056A1
Принадлежит:
A compound is represented by the following formula I. The compound and stereoisomer, racemate, tautomer, isotope labelled derivative, nitrogen oxide, pharmaceutically acceptable salt or solvate thereof can be prepared and used in the preparation of a medicament for treating a RET kinase-mediated disease. 3. The compound according to claim 1 , wherein:{'sup': 6', 'b, 'sub': 2', '1-6', '1-6', '2', '1-6', '1-6', '1-6', '1-6, 'Xis selected from —C-A or N, wherein A may be selected from H and the following groups which are unsubstituted or optionally substituted with one, two or more R: NH, Calkyl, —NH(Calkyl), OH, F, —NHC(O)Calkyl, —NHCalkyl, Calkyloxy, —NHCalkyl-OH;'}{'sup': 'b', 'sub': 1-6', '1-6, 'each Ris the same or different, and is independently selected from Calkyl and Calkoxy;'}{'sub': 2', '1-6, 'sup': 'c', 'B can be selected from H, CN, —CONH, and Calkyl which is unsubstituted or optionally substituted with one, two or more R;'}{'sup': 'c', 'sub': '1-6', 'each Ris the same or different, and is independently selected from halogen and Calkyl;'}{'sup': d', 'd, 'sub': 1-6', '1-6', '1-6', '2', '2', '1-6, 'D can be selected from the following groups which are unsubstituted or optionally substituted with one, two or more R: Calkyloxy or 5-14 membered heteroaryl, wherein Ris selected from Calkyl group and 3-10 membered heterocyclyl which are unsubstituted or optionally substituted with one or more groups selected from the following groups: oxo, halogen, OH, —N(Calkyl)or —S(O)—Calkyl;'}{'sup': 'e', 'sub': 1-6', '1-6, 'E is selected from H and the following groups which are unsubstituted or optionally substituted by one, two or more R: Calkyl and Calkoxy;'}{'sup': 'e', 'sub': '1-6', 'each Ris the same or different, and is independently selected from OH, F, and Calkyl groups;'}{'sub': 1-6', '2, 'G is selected from 3-10 membered heterocyclyl which is unsubstituted or optionally substituted by an oxo group, such as a grouped selected from piperazinyl and piperidinyl which ...
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