04-01-2018 дата публикации
Номер: US20180002334A1
Принадлежит:
The present invention relates to tricyclic heterocycles which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment of diseases such as cancer. 141-. (canceled)43. The method of claim 42 , wherein the proliferative disorder is cancer.44. The method of claim 43 , wherein the cancer is adenocarcinoma claim 43 , adult T-cell leukemia/lymphoma claim 43 , bladder cancer claim 43 , blastoma claim 43 , bone cancer claim 43 , breast cancer claim 43 , brain cancer claim 43 , carcinoma claim 43 , myeloid sarcoma claim 43 , cervical cancer claim 43 , colorectal cancer claim 43 , esophageal cancer claim 43 , gastrointestinal cancer claim 43 , glioblastoma multiforme claim 43 , glioma claim 43 , gallbladder cancer claim 43 , gastric cancer claim 43 , head and neck cancer claim 43 , Hodgkin's lymphoma claim 43 , non-Hodgkin's lymphoma claim 43 , intestinal cancer claim 43 , kidney cancer claim 43 , laryngeal cancer claim 43 , leukemia claim 43 , lung cancer claim 43 , lymphoma claim 43 , liver cancer claim 43 , small cell lung cancer claim 43 , non-small cell lung cancer claim 43 , mesothelioma claim 43 , multiple myeloma claim 43 , ocular cancer claim 43 , optic nerve tumor claim 43 , oral cancer claim 43 , ovarian cancer claim 43 , pituitary tumor claim 43 , primary central nervous system lymphoma claim 43 , prostate cancer claim 43 , pancreatic cancer claim 43 , pharyngeal cancer claim 43 , renal cell carcinoma claim 43 , rectal cancer claim 43 , sarcoma claim 43 , skin cancer claim 43 , spinal tumor claim 43 , small intestine cancer claim 43 , stomach cancer claim 43 , T-cell lymphoma claim 43 , testicular cancer claim 43 , thyroid cancer claim 43 , throat cancer claim 43 , urogenital cancer claim 43 , urothelial carcinoma claim 43 , uterine cancer claim 43 , vaginal cancer claim 43 , or Wilms' tumor.4550-. (canceled)51. The method of claim 42 , wherein L is CH claim 42 , S(═O) claim 42 , —CH(CHOH)— claim 42 , or —CH((CH)CH)—.52. ...
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