18-06-2008 дата публикации
Номер: CN0101199521A
Автор:
BOWEI WU,
XIAOLI LI,
QINGHUA LIU,
CAIHONG YANG,
YUAN LI,
QILONG FENG,
XIAOJIE BAI,
WU BOWEI,
LI XIAOLI,
LIU QINGHUA,
YANG CAIHONG,
LI YUAN,
FENG QILONG,
BAI XIAOJIE
Принадлежит:
The invention relates to the medicine field, particularly relating to a drug for treating arrhythmia, in particular to an application of Zacopride in preparing a drug for treating the arrhythmia. The invention aims at solving the problems that the present antiarrhythmic drugs have the effect of causing arrhythmia, and IK1 selective agonist has not been discovered at home and abroad so far. The Zacopride is an IK1 selective agonist which is discovered at present for the first time and is used on an antiarrhythmic drug. Used as a drug for treating ischemia-reperfusion arrhythmia, the Zacopride has the similar effect to that of lidocaine, takes effect stably and does not obviously affect the rhythm with wide safety range. In the experiments of arrhythmia induced by ischemia-reperfusion, lidocaine can make the rhythm slower, while the Zacopride has no obvious effect; and when the dosage of the lidocaine is increased by one-third, the antiarrhythmic effect is obviously weakened, while such phenomenon ...
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