02-02-2012 дата публикации
Номер: US20120030776A1
Автор:
Combs Katherin E.,
Culbertson Ling Ling,
de Sauvage Frederic,
Ding Zhiyong,
Edwards Joel,
Girgis Rosemary,
Horner Allison Anne Byers,
Junge Harald,
JUNUTULA Jagath Reddy,
Massey Erin Marie,
McLain Dina Rebecca,
MONTGOMERY Charles,
Payne Bobby Joe,
Phillips Heidi,
Qian Ni Nancy,
Rangel Carolina,
Sevaux Tracy Ellen Willis,
Shi Zheng-Zheng,
Sparks Mary Jean,
Stala Joy Anne,
Vogel Peter,
Ye Weilan
Принадлежит:
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO69122, PRO204, PRO214, PRO222, PRO234, PRO265, PRO309, PRO332, PRO342, PRO356, PRO540, PRO618, PRO944, PRO994, PRO1079, PRO1110, PRO1122, PRO1138, PRO1190, PRO1272, PRO1286, PRO1295, PRO1309, PRO1316, PRO1383, PRO1384, PRO1431, PRO1434, PRO1475, PRO1481, PRO1568, PRO1573, PRO1599, PRO1604, PRO1605, PRO1693, PRO1753, PRO1755, PRO1777, PRO1788, PRO1864, PRO1925, PRO1926, PRO3566, PRO4330, PRO4423, PRO36935, PRO4977, PRO4979, PRO4980, PRO4981, PRO5801, PRO5995, PRO6001, PRO6095, PRO6182, PRO7170, PRO7171, PRO7436, PRO9912, PRO9917, PRO37337, PRO37496, PRO19646, PRO21718, PRO19820, PRO21201, PRO20026, PRO20110, PRO23203 or PRO35250 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities. 1174-. (canceled)175. A method of identifying an agent that modulates a phenotype associated with a disruption of a gene which encodes for a PRO1079 polypeptide , the method comprising:(a) providing a non-human transgenic animal whose genome comprises a disruption of a gene which is an ortholog of a human gene that encodes for the PRO1079 polypeptide;(b) measuring a physiological characteristic of the non-human transgenic animal of (a);(c) comparing the measured physiological characteristic of (b) with that of a gender matched wild-type animal, wherein the physiological characteristic of the non-human transgenic animal that ...
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