12-12-2007 дата публикации
Номер: EP1863340A2
Автор:
Allison Anne Byers Horner,
Andrew Peterson,
Bobby Joe Payne,
Catherine Anne B. Clarke,
Charles A. Montgomery,
Colleen M. Viator,
Deanna Grant,
Erin Marie Massey,
Frederic deSauvage,
Jeffrey L. Schrick,
Joel Edwards,
Joy Stala,
Jung-Hua Yeh,
Katherin E. Combs,
Lorelei Diane Ketcherside,
Mary Jean Sparks,
Ni Nancy Qian,
Paul Godowski,
Peter Vogel,
Weilan Ye,
Wenhu Huang,
Zheng-Zheng Shi,
Zhiyong Ding
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO179, PRO181, PRO244, PRO247, PRO269, PRO293, PRO298, PRO339, PRO341, PRO347, PRO531, PRO537, PRO718, PRO773, PRO860, PRO871, PRO872, PRO813, PRO828, PRO1100, PRO1114, PRO1115, PRO1126, PRO1133, PRO1154, PRO1185, PRO1194, PRO1287, PRO1291, PRO1293, PRO1310, PRO1312, PRO1335, PRO1339, PRO2155, PRO1356, PRO1385, PRO1412, PRO1487, PRO1758, PRO1779, PRO1785, PRO1889, PRO90318, PRO3434, PRO3579, PRO4322, PRO4343, PRO4347, PRO4403, PRO4976, PRO260, PRO6014, PRO6027, PRO6181, PRO6714, PRO9922, PRO7179, PRO7476, PRO9824, PRO19814, PRO19836, PRO20088, PRO70789, PRO50298, PRO51592, PRO1757, PRO4421, PRO9903, PRO1106, PRO1411, PRO1486, PRO1565, PRO4399 or PRO4404 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
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