Application of central palladium phosphine ferrocenylimine complex for catalyzing and synthesizing amine-methylated aromatic compound

The invention belongs to the filed of organic catalysis and synthesis, in particular to an application of a central palladium phosphine ferrocenylimine complex for catalyzing and synthesizing an amine-methylated aromatic compound. The central palladium phosphine ferrocenylimine complex can conveniently synthesize various coupling products with aminomethyl skeletons and has high stability, less catalyst consumption, suitability for various halogenated aromatic compounds as substrates, mild reaction conditions, strong reaction specificity, high yield up to 87 percent, little pollution and less environmental influence.

Application of cyclopalladated ferrocenylimine-phosphine adduct in synthesis of asymmetric biaryl compound

The invention belongs to the technical field of organic synthesis, and in particular relates to an application of a cyclopalladated ferrocenylimine-phosphine adduct in synthesis of an asymmetric biaryl compound. In synthesis of the asymmetric biaryl compound, the cyclopalladated ferrocenylimine-phosphine adduct is utilized as a catalyst, and the catalyst has the advantages of good stability, efficient catalytic activity and wide applicability; and by utilizing the catalyst, a corresponding coupling product with high yield (up to 95%) can be obtained on the premise of smaller catalytic amount, and the synthesis process has the characteristics of mild reaction conditions, wide substrate range and strong reaction specificity.

Catalytic system for preparing N-Boc-aromatic amine compounds and preparation method and application thereof

The invention discloses a catalytic system for preparing N-Boc-aromatic amine compounds and a preparation method and application thereof. The catalytic system consists of palladium diacetate, phosphine XPhos and caesium carbonate, wherein the mol ratio of the palladium diacetate to the phosphine XPhos to the caesium carbonate is 1:3:(45-50). In the catalytic system, the palladium diacetate, the phosphine XPhos and the caesium carbonate have low price and are convenient and easy to obtain. By adopting the catalytic system, a corresponding coupling product can be prepared at high yield by taking BocNH2 and aryl halide as raw materials; in addition, the catalytic system has the advantages of mild reaction condition, easy operation, simple post treatment, wide range of action substrate, strong reaction specificity, high yield, less pollution to the environment and the like.

Ferrocenyl cycloimine palladium-phosphine adduct and preparation and application therefore

The invention belongs to synthesis of a catalyst and application therefore in organic synthesis, in particular to a ferrocenyl cycloimine palladium-phosphine adduct and preparation and application thereof. In the synthesis of arylboronic acid ester, the ferrocenyl cycloimine palladium-phosphine adduct is used as a catalyst which has favorable stability, high-efficiency catalytic activity and wide applicability and can be used for synthesizing a corresponding coupling product with high yield (as high as 93 percent) on the premise of lower catalytic amount. The invention has the advantages of mild reaction condition, wide substrate range and strong reaction specificity.

Application of central palladium phosphine ferrocenylimine complex for catalyzing and synthesizing amine-methylated aromatic compound

The invention belongs to the filed of organic catalysis and synthesis, in particular to an application of a central palladium phosphine ferrocenylimine complex for catalyzing and synthesizing an amine-methylated aromatic compound. The central palladium phosphine ferrocenylimine complex can conveniently synthesize various coupling products with aminomethyl skeletons and has high stability, less catalyst consumption, suitability for various halogenated aromatic compounds as substrates, mild reaction conditions, strong reaction specificity, high yield up to 87 percent, little pollution and less environmental influence.

Ferrocenyl imidazoliny palladium compound, its preparation method and its uses in catalytic synthesis of coupling product

Method for selectively synthesizing single chiral or double chiral ferrocenyl amine

The invention belongs to the field of chiral compound synthesis, in particular to a novel method for selectively synthesizing single or double chiral ferrocenylamines. The method comprises: adding sodium borohydride into an alcobolic solution of a ferrocenylimine compound at a temperature of no more than 5 DEG C, stirring the mixture for reaction for 7 to 10 hours, and obtaining a ferrocenyl sec-amine compound by separating and purifying products obtained after the reaction; and preparing an alcobolic solution of the ferrocenyl sec-amine, adding ammonium formate and a palladium-carbon catalyst into the alcobolic solution, heating the solution for refluxing for 1 to 3 hours, and obtaining the single or double chiral ferrocenylamines after post treatment. The method uses cheap sodium borohydride as a reducing agent, simplifies reaction steps, reduces reaction cost, requires mild reaction conditions, is easy to synthesize industrially and achieves 99 percent of diastereomers.

Ferrocenyl cycloimine palladium-phosphine adduct and preparation and application therefore

The invention belongs to synthesis of a catalyst and application therefore in organic synthesis, in particular to a ferrocenyl cycloimine palladium-phosphine adduct and preparation and application thereof. In the synthesis of arylboronic acid ester, the ferrocenyl cycloimine palladium-phosphine adduct is used as a catalyst which has favorable stability, high-efficiency catalytic activity and wideapplicability and can be used for synthesizing a corresponding coupling product with high yield (as high as 93 percent) on the premise of lower catalytic amount. The invention has the advantages of mild reaction condition, wide substrate range and strong reaction specificity.