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Применить Всего найдено 3. Отображено 3.
09-06-2010 дата публикации

Method for preparing oxaliplatin with very low content of impurities

Номер: CN0101723988A
Автор: GE ZONGMING, LIANG XIZHOU, LUO FENGMAO, PENG SUQIN, ZONGMING GE, XIZHOU LIANG, FENGMAO LUO, SUQIN PENG
Принадлежит:

The invention relates to a method for preparing oxaliplatin with very low content of impurities, and the prepared oxaliplatin is an anti-tumor drug. The preparation method comprises the steps of dispersing a raw material of cis-dichloro(trans-(-)-1,2-cyclohexanediamine) platinum in deionized water, adding silver nitrate, stirring and carrying out reaction for 0.5-2 hours at the temperature of 30-70 DEG C, filtering, adding 10% Kl water solution into filtrate for removing excess silver ions, heating to 30-60 DEG C, adding diatomite, stirring for 20-30 minutes, filtering, adding potassium oxalate monohydrate into the filtrate, stirring and carrying out the reaction for 4-10 hours at the temperature of 15-45 DEG C, filtering and obtaining a crude product; and placing the crude product into 45% ethanol water solution at the temperature of 50-70 DEG C, stirring the solution, filtering, carrying out cooling crystallization on the filtrate at 0-minus 20 DEG C, keeping the crystallization time ...

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Номер записи: 1
12-05-2010 дата публикации

Method for preparing zanamivir intermediate serving as compound resisting highly pathogenic avian influenza

Номер: CN0101704851A
Автор: GE ZONGMING, LIANG XIZHOU, LUO FENGMAO, LUO HONGPENG, PENG SUQIN, SHEN CHAO, ZONGMING GE, XIZHOU LIANG, FENGMAO LUO, HONGPENG LUO, SUQIN PENG, CHAO SHEN
Принадлежит:

The invention relates to a method for preparing zanamivir intermediate serving as compound resisting highly pathogenic avian influenza (5-acetylamino-3,5-didehydro-D-glycerol-D-galactose-2-enol methyl palmitate). The method comprises: obtaining hydrogen chloride solution of methanol through the reaction of acyl chloride and methanol, wherein the weight ratio of the acyl chloride to the methanol is 1:100-1,000; adding sialic acid to the hydrogen chloride solution of methanol, stirring, heating, performing reaction at the temperature between 20 and 60 DEG C for 2 to 8 hours, adding 0.1 equivalent (mol) of sodium acetate, adjusting pH between 6 and 7, continuing to stir for 10 minutes and stopping reaction, wherein the weight ratio of the sialic acid to the hydrogen chloride solution of methanol is 1:2-20, and reaction temperature is 20 to 60 DEG C; performing concentration under reduced pressure, performing distillation under reduced pressure till drying the obtained product and using water ...

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Номер записи: 2
04-07-2012 дата публикации

Method for preparing oxaliplatin with very low content of impurities

Номер: CN0101723988B
Автор: GE ZONGMING, LIANG XIZHOU, LUO FENGMAO, PENG SUQIN, ZONGMING GE, XIZHOU LIANG, FENGMAO LUO, SUQIN PENG
Принадлежит:

The invention relates to a method for preparing oxaliplatin with very low content of impurities, and the prepared oxaliplatin is an anti-tumor drug. The preparation method comprises the steps of dispersing a raw material of cis-dichloro(trans-(-)-1,2-cyclohexanediamine) platinum in deionized water, adding silver nitrate, stirring and carrying out reaction for 0.5-2 hours at the temperature of 30-70 DEG C, filtering, adding 10% KI water solution into filtrate for removing excess silver ions, heating to 30-60 DEG C, adding diatomite, stirring for 20-30 minutes, filtering, adding potassium oxalate monohydrate into the filtrate, stirring and carrying out the reaction for 4-10 hours at the temperature of 15-45 DEG C, filtering and obtaining a crude product; and placing the crude product into 45% ethanol water solution at the temperature of 50-70 DEG C, stirring the solution, filtering, carrying out cooling crystallization on the filtrate at 0-minus 20 DEG C, keeping the crystallization time ...

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Номер записи: 3