04-06-2024 дата публикации
Номер: CA3210863C
The present disclosure provides a truncated Evans Blue modified fibroblast activation protein inhibitor compound, the molecular structure of the compound having any one of the following structures shown in Formula (II-1) to Formula (II-8): Ng H 0 3 HNYN = Hq 54"0 NH2 0 0 c) ilk OH N = 410, rit,..,../..,y1,...Ni--,\N....7,/ 0 * 14/ 0. __ ilk -141' HN \--/ 'S.. 0 ."*--k Hd -0 ofirN N 'A %%SNIPPET%%,0 0)\'µ:NLe. N 3 1 OH HO-e 0 Formula (II-3), 0 NQk HN -.)-- NJ 0 --HS 0 IS' 0 NH2 0 0 / OH P- * N ilkai isiN trillis=N=Thr N \--./ 0 HN 0 Hd "0 ow-N- IN ,=\,0 OH 0 t.....,N HO-re 0 Formula (11-4), 2 Date Recue/Date Received 2023-12-12 Nc, H j_..N.A1 HN. HO 0 --F F 0 ...z_\ (r \ OH N 0-- ,----\ ,...,_/ Inv N Hd "0 0 t---i OFrN N0 N 3 ' OH 0 HO-? o Formula (II-5), NC, H 0 >ILI N FIN¨)\- \...+F 0-HO0 F . ¨ NH2 0 0 0 / = ,, ,-,, ....37 Nc..1....11,i1,,,....õ....õ,i,11õrr-õõ00õ....Ø0,,,õ0õ...õ...ANT--AN. _./..._,,, \ / N ,--1 OWN N'%%SNIPPET%% I\,,k' ) ' 0 N 1..._,N OH H04 0 Formula (II-6), 3 Date Recue/Date Recall/ad 2023-12-12 pic, H 0 µ... 0 F F ¨. WA 0 NH2 0 0 i 01 OH " Nr-'\N,j-jo * N jAL\ . ¨ \ it, .-1L..õ----TA try r...../ NV IP /- HN 0 `S.g.1 HO' \'' 0 /--1 OirN N,%%SNIPPET%% s.,;'N i g OH HO--e 0 Formula (II-7), or Nc, H HN--)0 ..... "..N 0 F F HO 0 -.... `S") NH2 0 0 c:o 410 OH l ,p1 ii. ik, orks".yiLi--\ ..../...1 ip N/ 0. iiii. N' HN \--)1 S%0 " Hd ' 0 P--1 OHrN rs(%%SNIPPET%% OH HO4 0 Formula (II-8). 4 Date Recue/Date Received 2023-12-12
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