Lipid gold nanoparticle compound for treating sepsis and preparation method thereof

The invention discloses a lipid gold nanoparticle compound for treating sepsis, and a preparation method of the lipid gold nanoparticle compound comprises the following steps: adding lauryl sodium sulfate SDS into a dispersion liquid of AuNPs, and uniformly dispersing; adding beta-MEA into the solution, continuously stirring for 4-10 hours, then filtering to remove SDS, centrifugally concentrating the residual liquid, dialyzing and purifying the concentrated solution, and after the purification is completed, adjusting the pH value to obtain a cation AuNPs solution; adding Claudin-5 overexpression plasmids into the solution, and stirring to react, so as to obtain an AC solution; the preparation method comprises the following steps: adding soybean lecithin, cholesterol and DOTAP into an eggplant-shaped bottle, adding a methanol solution, heating for dissolving, and cooling to remove methanol, so as to obtain lipidosome; and adding an AC solution into the eggplant-shaped bottle, oscillating ...