10-12-2020 дата публикации
Номер: US20200384003A1
Автор:
DING Shicheng,
Guo Li,
Ji Zhongwei,
LUO Yu,
Qin Lijun,
Qu Jing,
SUN Chuanmin,
ZHANG Cunqing,
ZHAO Fenqin,
ZHENG Qinyuan,
ZHOU Xiangyan,
Zhu Jingjie
Принадлежит:
The present invention relates to a novel use of a triterpenoid. In particular, the present invention provides a use of a compound of formula I, or an optical isomer thereof, or a racemate thereof, or a solvate thereof, or a pharmaceutically acceptable salt thereof, or a prodrug thereof in the preparation of a pharmaceutical composition or a preparation for preventing and/or treating ocular diseases caused by crystalline lens lesions. A novel finding of the present invention is that the compound of formula I can prevent and/or treat ocular diseases caused by crystalline lens lesions, such as prevention and treatment of cataracts, is safe, has low toxicity and few side effects, and has remarkable therapeutic efficacy and development and application prospects. 137-. (canceled)39. The ophthalmic composition of claim 38 , wherein the divalent linking group has 1-10 linking units selected from the group consisting of —CRaRb— claim 38 , —C(OH)Ra— claim 38 , —NRa— claim 38 , —O— claim 38 , —CO— claim 38 , wherein claim 38 , Ra and Rb are each independently selected from H claim 38 , C1-C6 alkyl claim 38 , C1-C6 haloalkyl claim 38 , C3-C6 cycloalkyl claim 38 , or benzyl;R1a, Rb, R2a, R2b, R3a and R3b are each independently selected from hydrogen, —OH, —CHO, —COOH, —SH, substituted or unsubstituted C1-C3 alkyl-OCO—, substituted or unsubstituted C1-C4 alkyl, -A-B, or Ra and R1b, R2a and R2b, and/or R3a and R3b constitute ═O; wherein, A is independently a substituted or unsubstituted C1-C4 alkylene, and B is independently —OH, —SH, C1-C3 alkoxy, —CHO, —COOH, ═O;{'sub': 2', '2, 'Z is (L1)m-L2=Y, m is 0, 1, 2, 3 or 4, and each L1 is independently —CH—, —CO—, —O—, —C(C1-C3 alkyl)H—, C(C1-C3 alkyl)-, —C(C1-C3 alkyl)O—, or —NH—, L2 is —CH═, or —C(C1-C3 alkyl)=;'}{'sub': 2', '2, 'Y is ═CH, ═CH-substituted or unsubstituted C1-C7 alkyl, ═C-(substituted or unsubstituted C1-C7 alkyl), ═CH-substituted or unsubstituted C2-C7 alkenyl, or ═CH— substituted or unsubstituted C2-C7 alkynyl;'}R5, ...
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