25-08-2022 дата публикации
Номер: US20220265836A1
Принадлежит:
A complex is provided comprising a conjugate in which a polymer having a boronic acid group and a compound having a diol structure are bonded, and a substance that is complexed with the conjugate. 1. A complex comprising:a conjugate in which a polymer having a boronic acid group is bonded to a compound having a diol structure; anda substance that is complexed with the conjugate.2. The complex according to claim 1 ,wherein the substance that is complexed with the conjugate is at least one selected from the group consisting of a protein, a virus, an inorganic particle, a nucleic acid, and a small molecule medicine.3. The complex according to claim 1 ,wherein the complex comprises the conjugate in which a polymer having a boronic acid group is bonded to a compound having a diol structure, and a protein.4. The complex according to claim 1 ,wherein the compound having a diol structure is a polyphenol.5. The complex according to claim 1 ,wherein the compound having a diol structure is at least one selected from the group consisting of tannic acid, gallic acid, and derivatives thereof.6. The complex according to claim 1 ,wherein the polymer has two or more boronic acid groups.7. The complex according to claim 1 ,wherein the boronic acid group is a phenylboronic acid group which may have a substituent or a pyridylboronic acid group which may have a substituent.9. The complex according to claim 1 ,wherein the polymer is at least one biocompatible polymer selected from the group consisting of a polyethylene glycol, an acrylic resin, a polyamino acid, a polyvinylamine, a polyallylamine, a polynucleotide, a polyacrylamide, a polyether, a polyester, a polyurethane, a polysaccharide, and copolymers thereof.10. The complex according to claim 1 ,wherein the polymer having a boronic acid group contains a first biocompatible polymer chain and a second biocompatible polymer chain that is different from the first biocompatible polymer chain.11. The complex according to claim 10 , ...
Подробнее