Настройки

Укажите год
-

Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

Подробнее
-

Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

Подробнее

Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Укажите год
Укажите год
Применить Всего найдено 3. Отображено 3.
21-01-2015 дата публикации

Host cell containing vector for expressing functional recombinant human coagulation factor VII and high-level expression method of functional recombinant human coagulation factor VII

Номер: CN104293737A
Автор: ZHANG QUAN'AI, ZHAO YI, ZHANG LUQING, ZHENG YAOWU, HE YONGJI, PAN WEIWEI, ZHAO FENGMEI, LIANG YALI, CAO PENGCHENG, ZHAO YARUI
Принадлежит:

The invention provides a host cell containing a vector for expressing a functional recombinant human coagulation factor VII and a high-level expression method of the functional recombinant human coagulation factor VII, and aims at establishing an expression vector containing F VII, GGCX and VKORC1 recombinant nucleic acids and improving the g-carboxylation modification of the recombinant F VII by virtue of coordinated expression of the GGCX and the VKORC1. The host cell contains the F VII recombinant nucleic acid (human coagulation factor VII), depending on which the vitamin K is coded, a VKORC1 (mouse vitamin K epoxide reductase complex subunit 1) recombinant nucleic acid and a GGCX (mouse g glutamyl carboxylase) recombinant nucleic acid, as well as an insulator (4X) recombinant nucleic acid; the high-level expression method of the functional recombinant human coagulation factor VII comprises the steps of establishing an expression vector, mediating the expression vector into a DHFR deficient ...

Подробнее
Номер записи: 1
30-05-2023 дата публикации

Tissue factor targeting nano antibody as well as preparation method and application thereof

Номер: CN116178558A
Автор: QU ZHICAN, YANG XIN, PAN WEIWEI, ZHANG QUAN'AI, LIANG XINXIN, LI JIANLI, HAO HUAHUA
Принадлежит:

The invention relates to the technical field of bioengineering, in particular to a nano antibody of a targeted tissue factor as well as a preparation method and application of the nano antibody. The two nano antibodies with high specificity and high affinity are screened from the constructed nano antibody library, can be specifically combined with tissue factor protein, can be used for detection of tumor cell surface tissue factors and detection of expression of tumor cell tissue factors by a Western Blot method, and provides a method for research of tissue factor functions.

Подробнее
Номер записи: 2
27-06-2023 дата публикации

Modified CPP polypeptide for inhibiting human papilloma virus infection, nano preparation prepared from modified CPP polypeptide and application of modified CPP polypeptide

Номер: CN116333059A
Автор: QU ZHICAN, ZHANG QUAN'AI, ZHAO YI, YANG XIN, PAN WEIWEI, LIANG XINXIN, LI JIANLI, HAO HUAHUA
Принадлежит:

The invention provides a modified CPP polypeptide for inhibiting human papilloma virus infection, a nano preparation prepared from the modified CPP polypeptide and application of the modified CPP polypeptide, and belongs to the technical field of biological medicines. According to the modified CPP polypeptide provided by the invention, two arginines and one lysine are added on the basis of a cell-penetrating peptide of human papilloma virus (HPV) 16, so that the performance of proteins necessary for HPV transportation in a targeted interference cell of the CPP polypeptide is not influenced, and the cell-penetrating efficiency is also improved. The invention further provides a CPP polypeptide liposome, and the stability of the modified CPP polypeptide is maintained. In addition, the invention further provides a nano preparation prepared from the polypeptide liposome and acidic electrolyzed water, the performance of the product in the aspect of inhibiting human papilloma virus infection is ...

Подробнее
Номер записи: 3