04-05-2011 дата публикации
Номер: CN0101531651B
Принадлежит:
The invention provides a method for preparing 3,4-dihydro-2H-1-benzopyran-2-carboxylic acid compound (I) and 3,4-dihydro-4-O-2H-1-benzopyran-2-carboxylic acid compound (II) which have optical activity. In the method, phenol derivatives and N-substitute maleimide are used as starting materials, the (II) compound is prepared by condensation, hydrolysis, separation, acylation and cyclization, and the (I) compound is prepared by reduction and hydrogenolysis of the compound (II). The invention has advantages of high optical purity of the obtained products, cheap and easily-obtained raw materials used in the synthetic process, mild reaction conditions, high yield, easy and simple operation, low cost and less ''three wastes'' pollution. (In the formula, R1 and R2 represent H, halogen, C1-C12alkyl, C3-C7cycloalkyl, C6-C12aryl, C1-C12alkoxy, C6-C12aryloxy, C1-C12alkylthio, C6-C12arylthioethyl, nitryl, carboxyl, hydroxyl, CF3, and NR3R4; R3 and R4 represent H, C1-C12alkyl and C6-C12aryl; R1 and R2 ...
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