26-11-2015 дата публикации
Номер: US20150335765A1
Принадлежит:
This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer cell imaging, cancer cell growth inhibition, and detecting cancer cells, for example. Compounds of the invention are preferentially taken up by cancer cells as compared to normal cells. This allows many uses in the cancer treatment, diagnosis, tracking and imaging fields. 130.-. (canceled)32. The method of claim 31 , wherein X is not halogen claim 31 , CN claim 31 , Me claim 31 , phenyl claim 31 , OH claim 31 , OMe claim 31 , OPh claim 31 , 4-O-Ph-NH claim 31 , 4-O-Ph-CHCHCOOH claim 31 , NH-Ph claim 31 , NHEt claim 31 , or S-Ph when Ris H.33. The method of claim 31 , wherein the cancer cells are imaged in vivo.34. The method of claim 31 , wherein the cancer cells comprise lymphoma claim 31 , myeloid leukemia claim 31 , bladder cancer claim 31 , brain cancer claim 31 , head and neck cancer claim 31 , kidney cancer claim 31 , lung cancer claim 31 , myeloma claim 31 , ovarian cancer claim 31 , cervical cancer claim 31 , bone cancer claim 31 , thyroid cancer claim 31 , adrenal gland cancer claim 31 , cholangiocarcinoma claim 31 , pancreatic cancer claim 31 , prostate cancer claim 31 , skin cancer claim 31 , liver cancer claim 31 , testicular cancer claim 31 , colon cancer claim 31 , or breast cancer cells.35. The method of claim 31 , wherein the electromagnetic radiation is near infrared radiation.36. The method of claim 31 , wherein X is OH claim 31 , 4-O-Ph-NH claim 31 , 4-O-Ph-CHCHCOOH claim 31 , 4-O-Ph-CHCHCONHS claim 31 , NH-Ph claim 31 , SEt claim 31 , 4-S-Ph-COOH claim 31 , 4-S-Ph-OH claim 31 , 4-O-Ph-COOH claim 31 , 4-O-Ph-NCS claim 31 , or 4-S-Ph-NCS.37. The method of claim 31 , wherein X is Cl and each Ris CH.38. The method of claim 31 , wherein Ris (CH)SOH and m is 1-6.39. The method of claim 31 , wherein Ris (CH)CHand m is 1-6.40. The method of claim 31 , wherein q ...
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