26-03-2020 дата публикации
Номер: US20200095259A1
Автор:
Ashweek Neil,
Beaton Graham,
Chen Mi,
Coon Timothy Richard,
Ewing Todd,
Jiang Wanlong,
Lowe Richard,
Moree Willy,
Rowbottom Martin,
Smith Nicole,
Wade Warren,
Zhao Liren,
Zhu Yun-Fei
Принадлежит:
GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: 129.-. (canceled)30. The compound that is 3-(2-{[4-chloro-3-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-benzoyl]-methyl-amino}-phenoxy)-propionic acid , or a pharmaceutically acceptable salt thereof.31. A pharmaceutical composition comprising the compound of claim 30 , or a pharmaceutically acceptable salt thereof claim 30 , and a pharmaceutically acceptable carrier or diluent.32. The compound that is 4-(2-{[4-chloro-3-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-benzoyl]-methyl-amino}-3-methyl-phenoxy)-butyric acid claim 30 , or a pharmaceutically acceptable salt thereof.33. A pharmaceutical composition comprising the compound of claim 32 , or a pharmaceutically acceptable salt thereof claim 32 , and a pharmaceutically acceptable carrier or diluent. This application is a continuation of U.S. patent application Ser. No. 15/210,470, filed Jul. 14, 2016, which is a continuation of U.S. patent application Ser. No. 14/592,690, filed Jan. 8, 2015, now issued as U.S. Pat. No. 9,422,310 on Aug. 23, 2016, which is a continuation of U.S. patent application Ser. No. 13/910,961 filed Jun. 5, 2013, now issued as U.S. Pat. No. 8,952,161 on Feb. 10, 2015, which is a continuation of U.S. patent application Ser. No. 13/293,943 filed Nov. 10, 2011, now issued as U.S. Pat. No. 8,481,738 on Jul. 9, 2013, which is a divisional of U.S. patent application Ser. No. 12/594,809, filed Feb. 22, 2010, now issued as U.S. Pat. No. 8,084,614 on Dec. 27, 2011, which application is a U.S. national stage application filed under 35 U.S.C. § 371 of International Patent Application No. PCT/US2008/059438, accorded an international filing date of Apr. 4, 2008, which claims the benefit of U.S. Provisional Application No. 60/910,621, filed Apr. 6, 2007, all of which applications are incorporated herein by reference in ...
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