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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Применить Всего найдено 4. Отображено 4.
25-07-2023 дата публикации

Levosimendan for injection and preparation method thereof

Номер: CN116473930A
Автор: LIU SHANKUI, LI SHENGCHAO, WANG JING, JIANG YUANXUN, ZONG TONGXIN, LIU FEIFEI, SUN XIAOLI, JIANG MINGMING, DONG GUANGJIN, WU LIHUA, SUN YINGJI, LI TIEJUN
Принадлежит:

The invention belongs to the field of pharmaceutical preparations, and provides levosimendan for injection and a preparation method thereof.The levosimendan for injection comprises levosimendan serving as an active ingredient, povidone, a cosolvent, a freeze-drying protective agent and a dilution stabilizer, the composition does not contain ethyl alcohol, and the composition is redissolved, diluted and administered through intravenous drip with a 0.9% sodium chloride injection or a 5% glucose injection. The irritation of ethanol to blood vessels can be avoided; the adopted special dilution stabilizer can remarkably improve the stability of the compatible solution, so that the medication safety is remarkably improved. The composition can be stored below 25 DEG C, and is convenient to transport and clinically apply. The preparation process of the levosimendan for injection is simple, adopts degerming, filtering and freeze-drying processes, and is suitable for industrial production.

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Номер записи: 1
21-07-2023 дата публикации

Butylphthalide nano-liposome freeze-dried powder injection and preparation method thereof

Номер: CN116459224A
Автор: LIU SHANKUI, ZONG TONGXIN
Принадлежит:

The invention relates to the field of medicines, in particular to a nano-liposome and a preparation method thereof. In particular, the invention relates to a butylphthalide nano-liposome powder injection for treating acute ischemic stroke and a preparation method thereof. The nano-liposome is mainly composed of butylphthalide or L-butylphthalide, phospholipid, cholesterol, a long circulating material, a negative charge material, a protective agent and a pH regulator. The butylphthalide nano-liposome is prepared by adopting a film dispersion method and a mixing cavity preparation method, and the mixing cavity technology is easier to realize linear amplification and is more suitable for amplifying the production scale. According to the invention, lipidosome inclusion solubilization is adopted, the use of sulfobutyl-beta-cyclodextrin and other types of cyclodextrin is completely abandoned, the toxic and side effects are reduced, the therapeutic index is improved, and the medication safety ...

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Номер записи: 2
30-06-2023 дата публикации

Nimodipine micelle injection and preparation method thereof

Номер: CN116350586A
Автор: LIU SHANKUI, WANG JING, JIANG YUANXUN, ZONG TONGXIN, GENG QIANQIAN, SUN XIAOLI, JIANG MINGMING, WU LIHUA, SUN YINGJI, LI TIEJUN
Принадлежит:

The invention belongs to the field of medicines, provides a nimodipine micelle injection and a preparation method thereof, and particularly relates to a high-concentration nimodipine micelle injection for intravenous drip, which is composed of an active component nimodipine and auxiliary materials such as phospholipid, cholic acid or salt thereof, a surface modification material, an isoosmotic adjusting agent, a pH adjusting agent and water for injection. According to the injection, the solubility of nimodipine is greatly improved, phospholipid and cholic acid which are physiologically compatible as auxiliary materials and a micelle system with good safety are selected for solubilization, an innovative film dispersion-hydration process is adopted, and ethanol is abandoned as a solubilizer in a prescription, so that the medication safety is remarkably improved. The injection can be directly diluted by the injection, the stability of the compatible solution is good within 24 hours, special ...

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Номер записи: 3
15-08-2023 дата публикации

Votioxetine xinaphthoate crystal form A and preparation method and application thereof

Номер: CN116589434A
Автор: LIU SHANKUI, BAN QIUYU, YAN JINGJING, ZHANG LIANG, WANG JING, ZONG TONGXIN, SUN XIAOLI, JIANG MINGMING, WU LIHUA, SUN YINGJI, LI TIEJUN
Принадлежит:

The invention provides a crystal form A of vothioxetine xinaphthoate (1-[2-(2, 4-dimethyl phenyl sulfenyl) phenyl] piperazine 1-hydroxy-2-naphthoic acid) and a preparation method of the crystal form A. The invention further provides a preparation method of the crystal form A of the vothioxetine xinaphthoate. The invention also provides a pharmaceutical composition comprising the crystal form and application of the pharmaceutical composition in medicine preparation. According to the invention, the orally disintegrating tablet is prepared from the vothioxetine xinaphthenate, and the solubility of the vothioxetine xinaphthenate in the oral cavity is reduced while the vothioxetine xinaphthenate is rapidly disintegrated and released, so that the vothioxetine xinaphthenate does not reach a taste bud threshold value, and And the operation is simple, and industrialization is easy to realize.

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Номер записи: 4